Dr RR Baliga's Internal Medicine MUST KNOW FACTS Podcasts for Physicians and Physician Extenders. Not medical advice. www.MasterMedFacts.com
In this week's exploration, I dive into the brain's hidden "plumbing"—the glymphatic and meningeal lymphatic systems—drawing from a remarkable report in Science magazine (Dec 2025). The piece outlines emerging Alzheimer's strategies ranging from VEGF-C and Aquaporin-4 gene therapy to vasomotion drugs, CO₂ breathing, massage-based lymphatic stimulation, and even experimental lymphovenous surgery. A quiet revolution is underway—hope flowing through the brain's deepest channels.
Delving into the latest JAHA review on immune checkpoint inhibitors and the heart has been illuminating
Immanuel Kant: The Architect of Modern Reason
Chronic kidney disease now affects nearly 850 million people worldwide, yet early detection and simple, evidence-based interventions can dramatically change the trajectory of both kidney and cardiovascular health.
New Lancet Seminar on heart failure with reduced ejection fraction.
Exploring David Hume
The U.S. heart failure landscape is transforming—and fast.
Respiratory vaccines are not just infection-fighters—they're cardiovascular protectors.
Thrilled to see a major step forward in dengue prevention!
Delighted to share a concise update on the latest NEJM review of Long QT Syndrome
New NEJM insights on asymptomatic carotid stenosis
The new Lancet Series on ultra-processed foods offers a striking insight: as UPFs rise globally, traditional whole-food diets decline—bringing nutrient imbalance, overeating, toxic exposures, and hyper-palatable formulations that quietly reshape health trajectories.
Home-delivered DASH-patterned groceries paired with dietitian counseling meaningfully lowered blood pressure and LDL cholesterol among Black adults living in food deserts
☕ DECAF Trial insight! A new JAMA study shows that daily caffeinated coffee may lower recurrence of atrial fibrillation compared with abstinence. Patients drinking ~1 cup/day had 47% recurrence vs 64% with abstinence (HR 0.61, p=0.01)
SOFA-2 is here — a major advance in assessing organ dysfunction in critical illness
Rethinking "default lines" in the ICU
The immune clock starts earlier than we think ⏳
A new era for complex mitral regurgitation. The ENCIRCLE pivotal trial in The Lancet reports that fully percutaneous, transfemoral, transseptal TMVR (SAPIEN M3) achieved durable MR reduction (≈96% ≤1+ at 1 year), low early mortality, and meaningful improvement in symptoms and quality of life for patients unsuitable for surgery or TEER. A third pathway for mitral disease is emerging—one built on precision access, valve-in-valve durability planning, and advancing patient selection. Innovation meeting clinical need.
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