Podcasts about Pearse

Barry Cullinane and Cahair O'Kane of The Irish News look ahead to Galway's clash against Dublin in round one of the All-Ireland series. This Podcast is brought to you by Hoare Chartered Accountants. Hoare Chartered Accountants based in Galway City are a leading provider of Audit, Accountancy and Taxation services.. For more information, visit their website on www.hoarecharteredaccountants.ieSubscribe for more content!Subscribe for more content!

Life, Culture and Current Events from a Biblical perspective.Your support sends the gospel to every corner of Australia through broadcast, online and print media: https://vision.org.au/donateSee omnystudio.com/listener for privacy information.

Life, Culture and Current Events from a Biblical perspective.Your support sends the gospel to every corner of Australia through broadcast, online and print media: https://vision.org.au/donateSee omnystudio.com/listener for privacy information.

Life, Culture and Current Events from a Biblical perspective.Your support sends the gospel to every corner of Australia through broadcast, online and print media: https://vision.org.au/donateSee omnystudio.com/listener for privacy information.

Life, Culture and Current Events from a Biblical Perspective, with guest host, Wedny FrancisYour support sends the gospel to every corner of Australia through broadcast, online and print media: https://vision.org.au/donateSee omnystudio.com/listener for privacy information.

EVERYTHING BAGELS TIA PEARSE APRIL 27 2025

 Kathleen Lynn – a Rebel WomanI hope you all had an enjoyable Easter. Across the island and further afield commemorations were held at countless locations to remember those who fought in the 1916 Easter Rising and in all of the generations of the freedom struggle. The Belfast turnout was big and Pearse Doherty, who made an exceptional speech, was given a very warm welcome. I saw no mention of his remarks or those of other republican speakers on RTE, BBC or other broadcasters. So much for public service broadcasting! The story of Easter 1916 reverberates with many remarkable accounts of courage as a small band of Irish Republicans took on the largest Empire ever to have existed in human history. They include many women. Among these are Julia Grenan, Winifred Carney and Elizabeth O'Farrell who were in the GPO and in Moore St. when the decision to surrender was taken. Winifred Carney's statue now stands proudly in front of Belfast City Hall.  Finding their place in a new IrelandIn his Easter remarks at the Republican Plot in Milltown Cemetery Teachta Pearse Doherty referenced the fact that the “momentum for Irish Unity grows stronger every day…. it is fast becoming the defining political project of our generation.” Pearse also addressed the importance of preparing for unity and in doing so the imperative of engaging with the unionist section of our people. He said: “There are many issues for republicans and unionists to talk about. We need to address the genuine fears and concerns of unionists in a meaningful way.”That means examining what they mean when they say they are British. We must be willing he said; “to explore and be open to new ideas. We need to look at ways in which the unionist people can find their place in a new Ireland.”  A Barren Landscape of DeathThe Gaza Strip is one eighth the size of County Antrim and has a population three times larger. Imagine if Belfast north of the River Lagan and including Mallusk and Newtownabbey were levelled to the ground. No schools, no hospitals, no homes – just tents – no churches, no shops, no transport system, no sewage system. A barren levelled landscape of death. Gaza City has been under strict Israeli siege for seven weeks. No bread, no water, no fuel, no medicines have been allowed to enter the area. The people – the children – are starving.  And all the time the international community with a few honourable exceptions does nothing – is complicit in this genocide.All that FussA friend of mine in County Tyrone was taking her seven year old daughter to her local Gael Scoil when the child drew her attention to the road sign for Londonderry. Someone had drawn a line through the London bit.‘Why is that  like that Mammy?' She asked. So Mammy gave a children's explanation. ‘But they are both wrong' the child replied ‘It's not Londonderry or Derry. Its Doire.'And that dear readers is why there is all that fuss about Irish or bilingual signage. 

So please be patient on this one cause in the beginning the podcast breaks up some because yes I recorded this while driving.... Sorry but trust me it gets better as it goes farther in. We will have to have them on for round two in a more proper way, but in the meantime I hope you enjoy this awesome dynamic duo of Pearse who is crushing it at downhill and enduro racing and Reeve who is crushing it as the supportive Dad and in his own right gnarly mtb'er. Their father/daughter dynamic shines through on this one and can't wait to ride with them soon. Hope you enjoy! https://www.instagram.com/pearse_mtb/https://www.instagram.com/erareeve/

Life, Culture and Current Events from a Biblical perspective, with guest host, Wendy Francis.Your support sends the gospel to every corner of Australia through broadcast, online and print media: https://vision.org.au/donateSee omnystudio.com/listener for privacy information.

Life, Culture and Current Events from a Biblical perspective.Your support sends the gospel to every corner of Australia through broadcast, online and print media: https://vision.org.au/donateSee omnystudio.com/listener for privacy information.

Life, Culture and Current Events from a Biblical perspective.Your support sends the gospel to every corner of Australia through broadcast, online and print media: https://vision.org.au/donateSee omnystudio.com/listener for privacy information.

Cathal Clancy and Gerry McGowan look back on Galway's defeat to Dublin and the lads also preview Galway's clash with Kerry this weekend This Podcast is brought to you by Hoare Chartered Accountants. Hoare Chartered Accountants based in Galway City are a leading provider of Audit, Accountancy and Taxation services.. For more information, visit their website on www.hoarecharteredaccountants.ieSubscribe for more content!

Christopher Luxon and the Indian Prime Minister have agreed on several priorities while in a private meeting yesterday, including on security. Luxon is leading a delegation in India this week and announced negotiations for a free trade agreement will kick off next month. The Herald's Adam Pearse is with Luxon and Narendra Modi, and told Andrew Dickens it's been a very cordial meeting. He says the pair have been getting along well, and are spending quite a bit of time together, taking part in things Modi wouldn't normally take part in. LISTEN ABOVE See omnystudio.com/listener for privacy information.

Life, Culture and Current Events from a Biblical perspective.Your support sends the gospel to every corner of Australia through broadcast, online and print media: https://vision.org.au/donateSee omnystudio.com/listener for privacy information.

Life, Culture and Current Events from a Biblical perspective.Your support sends the gospel to every corner of Australia through broadcast, online and print media: https://vision.org.au/donateSee omnystudio.com/listener for privacy information.

SHOW NOTESIn this episode, we covered:How ProSource has grown into a leading group with nearly 600 members.Jim's lessons from scaling businesses and navigating challenges.Tips for integrators to stay competitive with smart power and controlled lighting.Jim's expertise and vision for the future make this a must-listen for anyone in the integration industry. So settle in and enjoy my conversation with the one and only Jim Pearse. Let's get started!To get transcripts, resources of what was mentioned in the show, and more visit: onefirefly.com/au293 About One FireflyOne Firefly, LLC is an award-winning marketing agency that caters to technology professionals in the custom integration, security and solar energy markets. One Firefly is headquartered in Davie, Florida with staff located throughout North America and has been operating since 2007.

We’re updating this week’s political agenda with the Christian Lobby.Your support sends the gospel to every corner of Australia through broadcast, online and print media: https://vision.org.au/donateSee omnystudio.com/listener for privacy information.

Life, Culture and Current Events from a Biblical perspective.Your support sends the gospel to every corner of Australia through broadcast, online and print media: https://vision.org.au/donateSee omnystudio.com/listener for privacy information.

Life, Culture and Current Events from a Biblical perspective.Your support sends the gospel to every corner of Australia through broadcast, online and print media: https://vision.org.au/donateSee omnystudio.com/listener for privacy information.

ACT leader and soon-to-be Deputy Prime Minister David Seymour sent a detailed letter to police advocating for Philip Polkinghorne during the investigation into the death of Pauline Hanna, according to new reports. During the police investigation into the death of the Remuera eye surgeon's wife, Seymour wrote a 1012-word letter to Auckland District Commander Karyn Malthus in April 2022. NZ Herald political reporter Adam Pearse says Seymour accused police of acting 'inappropriately' and invading Polkinghorne's privacy. LISTEN ABOVESee omnystudio.com/listener for privacy information.

Brett Bailey speaks with fitness trainer Sean Pierce about expanding movement practices using tools like kettlebells and mace, as well as spirituality, emotional work, and men's work. Sean discusses his transition from professional soccer player to fitness trainer, stressing talent, fluidity, and the sensation of movement above merely looks. Comment below your biggest takeaway! Connect with Sean Pierce: Instagram: @sean.pearse His website: www.artofkettlebell.com/juggling And remember to book an absolutely FREE 30 minute, no strings attached call with me to get personal feedback & live coaching from me on how to turn 3 years of growth into 6 months of deep focus: https://api.leadconnectorhq.com/widget/bookings/discoverywithbrett Check out my website that explains the processes I've taken 200+ men through: https://brettbailey.vercel.app/ To start a private conversation, you can find me Instagram: ⁠⁠@brettbaailey⁠⁠ TikTok: ⁠⁠@brettbaailey⁠⁠ YouTube: ⁠⁠@brettbaailey⁠⁠ Telegram: @brettbailey And until next time brother, live a life that's true to YOU! The music used in this video is authorized under the Mixkit Stock Music Free License. It is permitted for use in commercial and non-commercial projects, including online platforms, podcasts, and advertisements.

The Green Party reached a significant milestone this weekend, off the back of a tough year for the party. It's been a year full of controversy following the arrest of Golriz Ghahraman, the referral of Julie Anne Genter to the Privileges Committee and the Darleen Tana saga that ended with the Greens using the Waka-Jumping law to oust her. The Party's also had to deal with leadership changes following James Shaw's retirement - but the sudden death of Efeso Collins and co-leader Marama Davidson stepping aside following a breast cancer diagnosis have also impacted the Greens. NZ Herald political reporter Adam Pearse says co-leader Chlöe Swarbrick is determined to move forward - as the party has big plans for 2025. LISTEN ABOVESee omnystudio.com/listener for privacy information.

This is part of the GAA Club Series of the Locker Room Podcast. Hosted by Steven Poacher from DSS Coaching, with special guest Mark Doran (Roscommon Senior Football team coach).  The discussion covers a range of topics including: 

The four-page Treaty Principles Bill has been introduced - and will be the subject of Parliament debate next week. Many are wondering about the bill's future, given that Prime Minister Chris Luxon has said his party won't support it past the select committee stage. NZ Herald political reporter Adam Pearse says Luxon won't even be in the country for its first reading - and will be looking to put some distance between himself and the bill ahead of the APEC summit in Peru. "He's going overseas and talking with world leaders, particularly at a time after the US election - it's a really important gig." LISTEN ABOVESee omnystudio.com/listener for privacy information.

Side Effects was back this week with new music from LCD Soundsystem, Adult DVD, Louis Dunford, Fionn Regan, and more.We also had some friends pick the tracks: Clevo, Luke, Nick, Pearse, Rich, and Ben!As promised, we're Making Mondays Happy Again!For more info and tracklisting, visit https://thefaceradio.com/side-effects.Tune into new broadcasts of Side Effects, LIVE, Monday from 2 - 4 PM EST / 7 - 9 PM GMT on The Face Radio.Dig this show? Please consider supporting The Face Radio: http://support.thefaceradio.com.Connect: https://linktr.ee/kurtispowers Support The Face Radio with PatreonSupport this show http://supporter.acast.com/thefaceradio. Join the family at https://plus.acast.com/s/thefaceradio. Hosted on Acast. See acast.com/privacy for more information.

Paul Byrne talks to Siobhan Cremin, sister of Pearse Cremin who went missing 24 years ago. If you have information please contact Anglesea St on 021 452 2000 Hosted on Acast. See acast.com/privacy for more information.

Paul Byrne hears what it's like patrolling Patrick St as a cop, talks about the leatherings dished out in schools, appeals for information about Pearse Cremin. And more... Hosted on Acast. See acast.com/privacy for more information.

In this episode of "Healing Her Halo," I'm thrilled to welcome Cristina Pearse, an inspiring survivor who's turning #MeToo into #MeHealed. Cristina shares her journey through PTSD and the life-changing experience she had with the MAPS.org MAPP2 clinical trial (MDMA-assisted therapy for PTSD). Fueled by her own healing, she founded the Protea Foundation to help other women reclaim their lives after trauma. Now, as she works toward her MA in Clinical Mental Health Counseling, Cristina is on a mission to connect the dots between trauma and mental health and to inspire others toward a fully actualized life.We dig deep into how Cristina's past as a serial entrepreneur, triathlete, and sommelier shapes her unique approach to healing, resilience, and empowerment. And, before we wrap up, I'm also excited to share some news on my latest release, *Alchemy*—a song that speaks to the transformation and magic in our journeys to healing.Tune in to hear Cristina's story and to catch a bit of "Alchemy," as we celebrate the power to turn pain into purpose.Or you can go stream "Alchemy" at the link below:https://linktr.ee/Paemurraymusic Connect with Cristina:https://www.proteafoundation.org Support Our Healing Her Halo Platforms:Be Sure to Follow & Share our Episodes, available on all podcast streaming platforms. https://www.buzzsprout.com/1491109 Instagram - @Healingherhalo : https://www.instagram.com/healingherhalo/Apple Podcasts: https://podcasts.apple.com/us/podcast/healing-her-halo/id1540565841Spotify: https://open.spotify.com/episode/0IgJzkLJ3oxncfG6MWSN1L#HealingHerHalo #MeHealed #Alchemy #PTSDRecovery #TraumaHealing #WomensMentalHealth #ProteaFoundation #MAPS #OvercomingTrauma #MentalHealthAwarenessSend us a text

New Zealand First faithful are hammering out policy ideas at their annual conference in Hamilton. More than 250 delegates are in attendance in a turn-out leader Winston Peters has dubbed the 'best crowd in decades'. NZ Herald political reporter Adam Pearse is expecting a 'lively' atmosphere at the party's first event since they got into Government. LISTEN ABOVESee omnystudio.com/listener for privacy information.

PPR Bonus podcast - Jacob Wohl - Ghislane Maxwell and alien DNA with Ed OppermanFebruary 15Ed Opperman on Porkins Policy Radio talking about Epstein, Maxwell and alien DNA. Pearse Redmond is an alternative researcher, published writer, and radio host in New York City. He covers a wide variety of topics including geopolitics, terrorism, cults, true crime, and deep politics. As host of Porkins Policy Radio Pearse has covered topics such as the OJ Simpson trial, the Jeffrey Epstein child trafficking case, inner workings of Scientology, and the CIA's role in destabilizing Jamaica. Pearse is the co-host of The CIA and Hollywood with Tom Secker, which explores the complex and incestuous relationship between the national security state and cinema. He is also the co-host of Porkins Great Game with Christoph Germann, where they explore the geopolitics of Central Asia, the Caucus, and the global war on terror.Youtube PodcastBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-opperman-report--1198501/support.

Think bourbon is the ultimate cigar pairing? Think again! In this eye-opening episode of The Root of All Success, cigar aficionado Paul Pearse breaks down why bourbon might actually be ruining your cigar experience. Paul dives deep into the flavor clash between bourbon's oaky, charred notes and a cigar's salty, woody profile, leaving you with a less-than-ideal pairing. So, what should you pair with a premium cigar? Paul reveals the best alternatives—like rum, brandy, and even champagne for lighter cigars—that can elevate and transform your smoking experience. He goes on to explain how acidity and sweetness from options like wine or Madeira bring balance to cigars, which are often missing these elements. Cognac and Armagnac also make the list, with Paul discussing the subtle differences between these spirits and why they work so well with cigars. Plus, he shares his take on the underrated Madeira, calling it a must-try for any cigar enthusiast. Whether you're smoking bold or mild, this episode gives you the secret to unlocking the full potential of your cigars. Don't settle for bourbon—explore the world of perfect cigar pairings with Paul Pearse! Paul's Website Link: franklincigar.com , thebaristonbar.com , marthasnashville.com Paul's Social Media: Instagram: @franklincigar , @nashvillecigar , @thearistonbar , @marthas_nashville Love the show? Subscribe, rate, review & share! https://therealjasonduncan.com/podcast This episode is sponsored by Dubb. Up your email game and make videos that convert! Get two free weeks and 50% off your first two months with this link: therealjasonduncan.com/dubb Learn more about your ad choices. Visit megaphone.fm/adchoices

Col Pearse has put everything into making it to these Paralympic Games but had to wait until the final night in the pool to claim a medal. He had finished in 4th place in the 100 metre Butterfly - the event he picked up a silver medal in at the Tokyo games. But he performed superbly to win silver in the 200m Individual Medley after two and a half weeks of "sleeping on cardboard beds and eating the same food every day". He told Ned Hall that seeing the 2nd place next to his name made all the sacrifices and hard work of the last 7 years worthwhile.

Send us a Text Message.I loved having Cass join me on this episode - she's always so much fun to chat with. Cass owns Mexico Cassie Goes International and she's authored two books: Moving To Mérida and Yucatán With Kids: A Travel Guide (also available in Spanish) Grab ALL the freebies I mention on the podcast PLUS so much more. All FREE! Grab it all here.===== FOLLOW ME ===== FB: https://www.facebook.com/groups/leslipeterson Podcast: https://podcast.leslipeterson.com/ ** Sometimes I link to additional resources, and they may or may not include affiliate links. I'll never link you to anything I don't use myself!

In this episode, we sit down with Sean Pearse, a movement specialist renowned for his innovative approach to three-dimensional movement, kettlebell, and mace training. Sean shares his insights on rope flow, the interconnectedness of physical skills, and the importance of balance and playfulness in practice. Learn how to cultivate awareness, explore new movement patterns, and connect deeply with your body through Sean's unique methodologies.Key Takeaways:Rope Flow: Using rope flow to enhance fluidity and body connection.Interconnected Movement: Integrating physical skills with personal development.Balance and Awareness: Avoiding stagnation by balancing extremes in practice.Presence and Play: Infusing playfulness to foster curiosity and relaxation.Geometry in Movement: Emphasizing circular pathways for enhanced fluidity.(00:02:29) Fluid Movement: Discovering Rope Flow's Rhythm(00:14:12) Embodied Awareness: Integrating Movement and Personal Growth(00:24:55) Dynamic Movement for Mind-Body Harmony(00:30:16) Childlike Engagement for Authentic Growth(00:42:52) Circular Pathways in Dynamic Movement(00:47:19) Infinite Body Exploration through Spherical Movements(00:48:26) Enhancing Presence Through Body Awareness(00:49:46) Embodied self-discovery through intentional movement practices(01:12:58) "Authentic Engagement Through Movement Exploration"(01:21:37) Embodied Self-Discovery Through Playful Movement Exploration(01:29:30) Spherical Movement and Self-Discovery with KettlebellsJoin us for a live 2 day in person workshop at our headquarters in San Luis Obispo, California, we're hosting a Multidimensional Movement Workshop on August 10-11, 2024.Follow SeanInstagram: @Sean.PearseArt of Kettlebell Course: https://artofkettlebell.com/Follow UsInstagram: @gymnazo_eduYoutube: Gymnazo EDUFacebook: Gymnazo EDUTikTok: @gymnazoedu

In this episode, we sit down with Sean Pearse, a movement specialist renowned for his innovative approach to three-dimensional movement, kettlebell, and mace training. Sean shares his insights on rope flow, the interconnectedness of physical skills, and the importance of balance and playfulness in practice. Learn how to cultivate awareness, explore new movement patterns, and connect deeply with your body through Sean's unique methodologies.Key Takeaways:Rope Flow: Using rope flow to enhance fluidity and body connection.Interconnected Movement: Integrating physical skills with personal development.Balance and Awareness: Avoiding stagnation by balancing extremes in practice.Presence and Play: Infusing playfulness to foster curiosity and relaxation.Geometry in Movement: Emphasizing circular pathways for enhanced fluidity.(00:02:29) Fluid Movement: Discovering Rope Flow's Rhythm(00:14:12) Embodied Awareness: Integrating Movement and Personal Growth(00:24:55) Dynamic Movement for Mind-Body Harmony(00:30:16) Childlike Engagement for Authentic Growth(00:42:52) Circular Pathways in Dynamic Movement(00:47:19) Infinite Body Exploration through Spherical Movements(00:48:26) Enhancing Presence Through Body Awareness(00:49:46) Embodied self-discovery through intentional movement practices(01:12:58) "Authentic Engagement Through Movement Exploration"(01:21:37) Embodied Self-Discovery Through Playful Movement Exploration(01:29:30) Spherical Movement and Self-Discovery with KettlebellsJoin us for a live 2 day in person workshop at our headquarters in San Luis Obispo, California, we're hosting a Multidimensional Movement Workshop on August 10-11, 2024.Follow SeanInstagram: @Sean.PearseArt of Kettlebell Course: https://artofkettlebell.com/Follow UsInstagram: @gymnazo_eduYoutube: Gymnazo EDUFacebook: Gymnazo EDUTikTok: @gymnazoedu

In this episode, we delve into the impact of the new groundbreaking research uncovering the RNU4-2 genetic variant linked to neurodevelopmental conditions. The discovery, made possible through whole genome sequencing, highlights a genetic change in the RNU4-2 gene that affects about 1 in 200 undiagnosed children with neurodevelopmental conditions, making it more prevalent than previously thought. This discovery represents one of the most common single-gene genetic causes of such conditions. Our host, Naimah Callachand, Head of Product Engagement and Growth at Genomics England, is joined by Lindsay Pearse who shares her journey through the diagnosis of her son Lars. They are also joined by Sarah Wynn, CEO of Unique, and Emma Baple, Clinical Genetics Doctor and Professor of Genomic Medicine in the University of Exeter and the Medical Director of the Southwest NHS Genomic Laboratory Hub. We also hear from the 2 research groups who independently discovered the findings: Dr Andrew Mumford, Professor of Haematology at the University of Bristol Link to the research paper: https://www.nature.com/articles/s41591-024-03085-5  Assistant Professor Nicky Whiffin, Big Data Institute and Centre for Human Genetics at the University of Oxford Link to the research paper: https://www.nature.com/articles/s41586-024-07773-7 To access resources mentioned in this podcast:  Unique provides support, information and networking to families affected by rare chromosome and gene disorders - for more information and support please visit the website. Connect with other parents of children carrying a variation in RNU4-2 on the Facebook group.   "I think one of the things we really hope will come out of diagnoses like this is that we will then be able to build up more of that picture about how families are affected. So, that we can give families more information about not only how their child is affected but how they might be affected in the future."   You can read the transcript below or download it here: https://www.genomicsengland.co.uk/assets/documents/Podcast-transcripts/How-has-a-groundbreaking-genomic-discovery-impacted-thousands-worldwide.docx  Naimah: Welcome to Behind the Genes. Lindsay: So, this feeling that like we've been on this deserted island for eight years and now all of a sudden, you're sort of looking around through the branches of the trees. It's like, wait a minute, there are other people on this island and in this case actually there's a lot more people on this island. Yeah, it's very exciting, it's validating. It gives us a lot of hope and, you know, it has been quite emotional too and also a bit of an identity shift. Being undiagnosed had become quite a big part of our identity, and so now that's kind of shifting a little bit that we have this new diagnosis and are part of a new community. Naimah: My name is Naimah Callachand and I'm Head of Product Engagement and Growth at Genomics England. On today's episode, I'm joined by Lindsay Pearse whose son Lars recently received a genetic diagnosis, made possible by research using data from the National Genomic Research Library, Sarah Wynn CEO of Unique, and Emma Baple, a clinical genetics doctor. Today we'll be discussing the impact of recent research findings which have found a genetic change in the non-coding RNU4-2 gene, to be linked to neurodevelopmental conditions. If you enjoy today's episode, we'd love your support. Please like, share and rate us on wherever you listen to your podcasts. Naimah: And first of all, I would like everyone to introduce themselves. So, Lindsay, maybe if we could come to you first. Lindsay: Great, thank you. So, thank you for having me. I'm Lindsay Pearse, I live outside of Washington DC and I'm a mum to 3 boys. My oldest son Lars who is 8, he was recently diagnosed with the de novo variant in the RNU4-2 gene. Naimah: Thank you. And Emma? Emma: My name is Emma Baple. I'm a Clinical Genetics Doctor which means I look after children and adults with genetic conditions. I'm also a Professor of Genomic Medicine in the University of Exeter and the Medical Director of the Southwest NHS Genomic Laboratory Hub. Naimah: And Sarah? Sarah: Hi, thank you for having me. I'm Sarah Wynn, I'm the CEO of a patient organisation called Unique, and we provide support and information to all those affected by rare genetic conditions. Naimah: Great, thank you. It's so great to have you all here today. So, first of all Lindsay, I wonder if we could come to you. So, you mentioned in your introduction your son Lars has recently been diagnosed with the de novo variant. I wondered if you could tell us a bit about your story, and what it's been like up until the diagnosis. Lindsay: Sure, yeah. So, Lars is, he's a wonderful 8 year-old boy. With his condition, his main symptoms he experiences global developmental delays, he's non-verbal. He's had hypertonia pretty much since birth and wears AFO's to support his walking. He has a feeding disorder and is fed by a G-Tube. Cortical vision impairments, a history of seizures and slow growth, amongst other things. So, that's just a bit of a picture of what he deals with day to day. But he's my oldest child, so first baby. When I was pregnant, we were given an IUGR diagnosis. He was breech, he had a hernia soon after birth, wouldn't breastfeed. But all of these things aren't terribly uncommon, you know. But once he was about 3 or 4 months old, we noticed that he wasn't really able to push up like he should, and we were put in touch with early intervention services for an assessment. So, we went ahead and did that when he was about 4 or 5 months old. And as parents, we could just kind of tell that something was off from the assessors. And, you know, they were very gentle with us, but we could just get that sense that okay, something is off, and they're worried here. So, that kind of kickstarted me into making appointments left, right and centre with specialists. The first specialist that we saw was a neurologist. And yeah, again, that's another appointment that I'll never forget. She referred us to genetics and to get an MRI and some lab work but at the end of the appointment, she said to us, ‘Just remember to love your child.' And, you know, that was quite shocking to us at the time because it wasn't something that had ever crossed our mind that we wouldn't do or felt like we needed to be told to do this. But on the other hand, it certainly set off a lot of worry and anxiety of okay, well, what exactly are we dealing with here? So, fast forward, we saw genetics and that was about when Lars was about 8 months old. We went through a variety of genetic testing, a chromosomal micro-array, a single gene testing, then the whole exome testing. Everything came back negative, but it was explained to us that what was going on was likely an overarching genetic diagnosis that would explain his like, multi-system symptoms. And so meanwhile as he was getting older his global delays were becoming more pronounced and we were also in and out of the hospital a lot at this time. At first, he was in day care and, you know, any sort of cold virus would always turn into like a pneumonia for him. So, we were just in and out of hospital seeing a myriad of specialists, trying to put together this puzzle of what's going on and it was really hard to accept that nobody could figure it out. That was just, you know, sort of mind-blowing to us I guess. So, we applied for and were accepted into the Undiagnosed Diseases Programme at the National Institute of Health over here. The NIH as it's commonly referred to. So, we first went there when Lars was 2. He was one of their youngest patients at the time. But that was a really great experience for us because we felt like they were looking at him holistically and across a bunch of all of his systems, and not just seeing a specialist for sort of each system. So, we really appreciated that. We also did the whole genome sequencing through this research study. Although that also came back negative and so at that point, we were told to kind of keep following up symptomatically. Keep seeing the specialists and eventually maybe one day we'll find an overarching diagnosis, but that science just hadn't quite caught up to Lars. It was hard for me again to believe that and to sort of wrap my head around that. But certainly, it was an education from all of the doctors and geneticists and everyone we saw at NIH, to realise like how far there still was to go in terms of genetic research. How it wasn't also that uncommon to be undiagnosed in the rare disease community. I would say that being undiagnosed sort of became part of our identity. And it's, you know, it was something that, you know, you had to explain to like insurance companies and to his school, and it became part of our advocacy around him. Because without being able to say oh, it's this specific thing and if it was someone who hadn't met Lars before, trying to explain to them that, you know, yeah, within the range of this community you can be undiagnosed, and they just haven't found it yet, but I promise you there is something going on here. And I'd say the other thing too without a diagnosis you have no prognosis, right? And so, trying to figure out what the future would look like. Also, family planning. We waited 5 and a half years before we had another child and, you know, it was certainly an anxiety ridden decision. Ultimately after seeing as many specialists as we possibly could, we still were left with the same answer of well, we just don't really know if it will happen again. So, that was a big decision to make. But again, it just kind of became part of our identity and something that you did eventually accept. But I would say in my experience I feel like the acceptance part also of Lars' disabilities perhaps took me a little bit longer. Because again, I didn't have a prognosis, so I didn't exactly know what we were dealing with. Only as he has become older and, you know, you're sort of getting a better sense of what his abilities might be than being able to understand, okay, this is what I'm dealing with. I need to accept that and do what I can to care for him and our family in the best way that we can. Naimah: Thanks so much for sharing that, Lindsay. I feel like you've touched on a lot of really, you know, a lot of complications and difficulties for your family. Especially, you know, with regards to keeping hopeful and things about the prognosis as well, I'm sure it was really difficult. You've mentioned that Lars was able to be diagnosed recently due to recent research efforts. So, Sarah, I wonder if you can tell us a bit more about these and what the findings have meant for patients with neurodevelopmental conditions. Sarah: Yes. So, I think we know that there are lots of families that are in Lindsay and Lars' position where they know that there is almost certainly an underlying genetic condition, and it just hasn't been found yet. And so, I think we know that lots of researchers are working really hard to try and find those causes. I think over time we know that as time goes on and research goes on, we'll find more of these new genetic causes for neurodevelopmental conditions. I think particularly as we start to look at regions of the genome that we haven't looked at so much so far. But I think one of the things that's really extraordinary about this one is that actually it turns out to be much more common than we might have expected, for one of these new conditions that we haven't found before. But I think it's about one in 200 of those undiagnosed children with neurodevelopmental conditions, have this diagnosis so that's not a small number. That's not a rare finding at all actually, that's much more common than we could ever have anticipated. But I think one of the things that we do know is that as we look further and deeper into that genomic sequence, so, we've started off looking at the bits of the sequence that are genes that code for proteins. This changes in a gene that actually doesn't code for protein, so it's less obvious that it would be important but clearly it is important in development because we know when it has a spelling mistake in it, it causes this neurodevelopmental condition. But there will be as researchers look more and more at these kinds of genes, and also the other part of the genome that is not genes at all, we'll find out more and more the underlying genetic causes of these neurodevelopmental conditions. I think it's also really important to stress why this is so important to find these genetic changes and it's because families really need a diagnosis. Lindsay talked quite eloquently and a lot about that knowing something was off and really wanting to know the reason why. Getting these diagnoses might change care management or treatment, but actually really importantly it just gives an answer to families who have often been looking for an answer for a really long time. Naimah: I just wanted to go back to the point that Sarah made that actually this genetic change is relatively common. Emma, I wondered if you could tell us a bit more about maybe why it took us so long to discover it? Emma: That's an interesting question actually. I suppose the sort of slightly simplified answer to that question is we haven't been able to sequence the whole of a person's genetic information for that long. And so, children like Lars would have had, as Lindsay described lots and lots of genetic tests up until they had a whole genome sequencing which is what Sarah was talking about. The types of tests that we had up until the whole genome sequencing wouldn't have allowed us to look at that bit of the genetic code where this RNU4-2 gene can be found. So, we can only really find that using whole genome sequencing. So, before that existed, we wouldn't have been able to find this cause of developmental condition. Naimah: Okay, thanks Emma. Naimah: Now we're going to hear from one of the two research groups who are responsible for these research findings. First of all, let's hear from Nicky Whiffin. (Clip - Nicky Whiffin) Naimah: How were the findings possible using the Genomics England dataset? Nicky: So, most previous studies have only looked at genetic variants that, in genes that make proteins, but only a subset of our genes actually do makes proteins. The Genomics England dataset we have sequencing information on the entire genome, not just on these protein coding genes and that means we can also look at variants in other genes. So, those that make molecules other than proteins. And RNU4-2 for example, makes an RNA molecule. Naimah: These findings translated to direct patient benefit for patients like Lars who were able to receive support from Unique. How does this demonstrate the value of the dataset? Nicky: Yes. So, it was incredible that we could find so many patients with RNU4-2 variants so quickly. This was enabled by access to Genomics England data but also to other large sequencing datasets around the world. So, we worked with people in the US, in Australia and also in mainland Europe. These large datasets enabled us to spot consistent patterns in the data and by looking across multiple datasets we can also make sure that our findings are robust. When we realised how significant this was and how many families would be impacted, we very quickly contacted Sarah at Unique to see if we could direct patients to them for support. (End of clip) Emma: There's one thing I wanted to raise. It's important to recognise the way that was discovered was through the National Genomic Research Library that Genomics England hosts. To highlight the value of that, and the value of having this centralised resource where families have been kind enough really to allow their data to be shared with some limited clinical information that allowed these researchers to be able to pull this out. And I think it highlights the power of the National Health Service in that we were able to create such a resource. It's really quite astounding that we've found such a common cause of a rare genetic condition, and it wouldn't have happened in the same timescale or in this way without that resource. And then to just say that as Sarah talked about the fact that we've been able to get that information out there, also the researchers were able to get out there and contact the NIH and all of these other programmes worldwide. In Australia, America, everywhere in the world and quickly identify new patients who had this condition and get those diagnoses out really rapidly to people. But all that came from that power of sharing data and being able to have that all in one place and making it accessible to very clever people who could do this work and find these answers. It's so important for families like Lindsay's, and all the families in England and around the world that have got these answers. So, I guess it's a big plug for the value of data sharing and having a secure place where people feel that it's trusted and safe, that enables these diagnoses to be made. Lindsay: If I could just echo that, we're so grateful that that exists in the UK. Just acknowledging like the privilege here that we have had to be able to, I mean for our family in the US, that we've been able to, you know, get ourselves into the NIH study and into the study at Children's National. That takes a lot of work. I feel like not everybody has that opportunity to be able to spend the time to do these applications and to go to all the appointments and get the testing done and have the insurance to cover it. So, very grateful that the system exists in a way in the UK that made this sort of research possible. I just hope that that can be replicated in other places, and also to what Emma was saying earlier, come up with a lower cost test as well for this to further the growth of the community and of course then the corresponding research. Sarah: I think firstly we have to sort of thank all of those families that took part and do share their data, because I think it's not always clear why you might want to do that as a family. I think this is really a powerful example of the benefit of that. I also think the data sharing goes one stage further. So, it's partly about getting the diagnosis, but the data sharing going forward about how this condition impacts families, both clinically and sort of day to day lived experience, is how we'll be able to learn more about these conditions. And so, when families get this diagnosis next week or next year, not only will they get a diagnosis, but they'll get a really good idea about what the condition is and how it might impact their child. Naimah: And Lindsay, coming back to you. So, we've talked about, you know, what it meant for your family before the diagnosis, but what has it meant to have a diagnosis and how did you feel? And what happened whenever you received the diagnosis? Lindsay: Sure. Lars was again part of the NIH Undiagnosed Diseases Research study. So, once you attend this programme and if you are not diagnosed like at the end of your stay, they keep your details on file and you're part of this database at the NIH Undiagnosed Diseases Programme. So, if you're undiagnosed after your sort of week-long work up, your samples stay within the research programme. We were also part of a research programme at Children's National Medical Centre, the Rare Disease Institute. So, our samples were sort of on file there in their database as well. And so, at the end of March I was really quite shocked to receive a call from our long time and trusted geneticist at Children's National that they had found a diagnosis. It was quite emotional. I really kind of didn't believe it. I just kept asking, you know, ‘Are you sure? Is this it?' you know, ‘How confident are we?' Because I think in my head, I sort of always thought that we would eventually find a diagnosis, but I thought that Lars would be, you know, a 30- or 40-year-old adult. I thought it would be decades from now. Like I felt like for whatever reason we had to wait decades for the science to sort of catch up to him. So, we were very, very grateful. It felt very validating, I guess. I had always kind of had this intuition feeling that we were sort of missing something and it's more that the science just hadn't quite caught up yet. But, you know, it was validating to know that okay, Lars is not the only person in the entire world with this, it is something that is relatively common in fact within the rare disease community. That is also very exciting to me personally because I'm hopeful that that will lead more researchers to be interesting in this, given how, quote on quote, common it is. I've sort of been describing it as like a mass diagnosis event but also more so this feeling that like we've been on this deserted island for eight years and now all of a sudden, you're sort of like looking around through the branches of the trees. It's like, wait a minute, there are other people on this island ad in this case, there's actually a lot more people on this island. Yeah, it's very exciting, it's validating. It gives us a lot of hope. And, you know, it has been quite emotional too and also a bit of an identity shift. Because I spoke earlier about how like being undiagnosed had become quite a big part of our identity. So, now that's kind of shifting a little bit that we have this new diagnosis and are part of a new community. But yeah, we're just very grateful that the research had continued. And, you know, I think sometimes you sort of have this feeling of okay, our files are up on a shelf somewhere, you know, collecting dust and are people really looking at them? And actually, it turns out that the research was ongoing and yeah, we're just very grateful for that. Naimah: Thanks so much for sharing, Lindsay. It sounds like it's been a real rollercoaster of emotions for your family and I'm glad to hear that, you know, you've got some hope now that you've got a diagnosis as well. So, moving onto the next question. Emma, I wanted to ask you then, how will these findings improve clinical diagnostic services for those for neurodevelopmental conditions? Emma: So, you asked me earlier about why it had taken so long to find this particular cause of neurodevelopmental condition, and I gave you a relatively simple answer. The reality is one of the other reasons is that almost eight out of ten children and adults who have RNU4-2 related neurodevelopmental condition have exactly the same single letter spelling change in that gene. So, actually that in itself means that when researchers are looking at that information, they might think that it's actually a mistake. Because we know that when we sequence genetic information, we can see mistakes in that sequencing information that are just because the machine has, and the way that we process that data, it's not perfect. So, sometimes we find these little mistakes and they're not actually the cause of a person's problems, they're just what we call an artefact or an issue with the way that that happens. So, that is part of the reason for why it was tricky for us to know whether this was, or rather the researchers to know whether this was or was not the cause of this particular condition. But that in itself is quite helpful when we think about how we might identify more people who have this going forwards. Because unlike in Lars' case where we didn't know what the cause was and so we were still searching, and we didn't know where to look in the billions of letters that make up the genetic code to find that answer, we now know that this is really very common. It's unbelievably common. I think we didn't think we would be finding a cause of a rare genetic condition that was this commonly occurring at this stage. But the fact that it's just a single, it's commonly this one single change in the gene means that we can set up pretty cheap diagnostic testing. Which means that if you were somewhere where you wouldn't necessarily have access to whole genome sequencing, or a more comprehensive testing in that way, we could still be able to pick up this condition. And it's common enough that even if you didn't necessarily recognise that a person had it, you could still have this as part of your diagnostic tool kit for patients who have a neurodevelopmental condition. It's common enough that just doing a very simple test that could be done in any diagnostic lab anywhere in the world, you would be able to identify the majority of people who have this. Naimah: Now let's hear from the other research group who are responsible for these findings. Here is Dr Andrew Mumford. (Clip - Dr Andrew Mumford) Naimah: Why are these research findings significant? Andrew: It offers genetic diagnosis not just for a handful of families but potentially for many hundreds of families, who we all know have been searching often for many, many years for a genetic diagnosis. But actually, there are other gains from understanding how this gene causes neurodevelopmental disorder. We know that there's GRNU4-2 in codes, not a protein actually, but a small nuclear RNA which is unusual for rare, inherited disorders. It's a component of a very complicated molecule called the spliceosome which in turn regulates how thousands of other genes are regulated, how they're made into proteins. So, fundamentally this discovery tells us a lot about the biology of how the spliceosome works. We already know that some other components of the spliceosome can go wrong, and result in diseases like neurodevelopmental disorders. This gives us an extra insight and actually opens the door to, I hope, a whole load of more discoveries of genetic diagnosis possible from other components of this complicated molecule. Naimah: Your research group used a mathematical modelling approach. Can you tell me a bit about this, and what this means for other rare conditions, Andrew? Andrew: So, identifying relationships between changes in individual genes and different kinds of rare, inherited disease is notoriously difficult because of the volume of data that's involved and the need to be absolutely certain that observed genetic changes are actually the cause of different rare, inherited disease. So, applying statistics to that kind of problem isn't new. But what my collaboration group have achieved here, is to develop, actually developed some years ago a completely new approach to applying statistics to genetic data. We call that BeviMed and we've been working for many years on the genes in code that make individual proteins. Most rare disorders are caused by genetic changes in genes that make proteins. What this discovery comes from is actually we've applied the BeviMed statistical technique to genes that don't make proteins, they're non-coding genes. For example, genes that make small nuclear RNA, it's just like RNU4-2. What's unusual about the BeviMed approach is that it's very sensitive to detecting links between genetic changes and rare diseases, and it can detect statistical associations really driven by very, very small numbers of families. So, we apply it to datasets like the 100,00 Genomes dataset and identify associations using statistics that have got a very high probability of association. Other members of the team then seek to corroborate that finding by looking at if we can see the association in other datasets, and we certainly achieve that with RNU4-2. But also, assessing biological plausibility by investigating what we understand already about in this case, a small nuclear RNA, and how it can possibly result in a disease. And we normally try and employ other independent evidence such as experimental investigation. Or going back to our families and asking for additional data to help really test this sort of theory that changes in this particular gene have resulted in a problem with neurodevelopment. (End of clip) Naimah: Emma, are there any other ways that we can identify these conditions based on their clinical presentation? Emma: So, Lindsay and I were talking with you just yesterday, wasn't it? And I asked Lindsay about what sorts of things Lars had in common with other children and adults who have been diagnosed with this condition? I actually think Lindsay probably gives a better summary than I would, so I might ask you to maybe repeat what you said to me yesterday. But the bit of it that really stood out to me was when you said to us that a lot of parents have said, ‘I'm not sure how we weren't all put together in the first place because you notice so many things that were in common.' So, maybe if you can give that summary and then I can translate that back into medical terms, if that's okay Lindsay. Lindsay: Sure, of course. Yeah, it been again, kind of mind blowing, some of the similarities. Especially as we've exchanged pictures and such, and baby pictures especially where some of the children like look like siblings. So, definitely some similarities in facial features, you know, everyone seems to experience some of the slow growth, so a short stature or quite skinny. There's feeding issues also that seem to be quite common. Also, you know, things like the global developmental delays, that's certainly across the board and histories of seizures, that's also quite common. Some people have experienced also some, like, bone density issues, that's not something that we've experienced so far, but that also seems to be quite common. But then also, behaviourally, there's a lot of similarities which has been, I think, quite exciting to a lot of us because you've always thought okay, so this is just my child. And of course, some of that is true but it's also interesting to find out some of these other things that are, you know, are quite similar. So, a lot of people have mentioned their child having, like, an interesting sense of humour. Kind of like a very slapstick sense of humour which is quite interesting. Or everyone seems to love water, everybody loves swimming pools and bathtime, and all of that. Lars loves a windy day. Something about the wind, he just loves it and plane noises and things like that have also come up with other people. So, yeah, it's been really interesting and cool to see. Emma: So, I guess Lindsay's sort of very beautifully summed up what is written in the research publication. So, there's only two research publications so far on this condition, it's all really new. And I am definitely not claim to be a clinical expert on this condition, and I don't think there are any yet. It will take people time to see lots of children and adults who have this particular condition. But ultimately what Lindsay summarised was the common clinical features that have been described by parents. In my job as a clinical genetics doctor, part of what we look at is a person's appearance. So, Lindsay described the photographs of children particularly when they were little, looked very similar. In the photographs that I've seen, I would agree with that. And so obviously those children look like their mum and dad, but they have other features that are in common. They have a characteristic appearance and that helps doctors like me to have an idea as to whether a child or an adult might have a particular condition. Then put together with the sorts of information that Lindsay gave us around the low tone, so being a little bit floppier particularly when they're little. The slow growth and growth problems, problems with eating, also with seizures. Those are all common things that were pulled out of both of the two research publications on this condition and putting that all together into one picture helps doctors to have an idea whether somebody may have a particular condition. That would help us in this case to potentially request that simple test I was talking about, if maybe we were practicing in a part of the world where we wouldn't have the resources that we thankfully do have in the United Kingdom, and in the USA. Naimah: So, Sarah, just coming to you next. How does this research spread awareness and help other patients with these conditions? Sarah: So, I think one of the things that's been really great about research now is that we are able to, you know, social media and things like that mean that we can spread this information really quickly across the world basically. I think what that does is that as well as helping bring people together that they've got this diagnosis, what it does is I think it provides hope for all of those people that Lindsay was talking about at the beginning who don't have a diagnosis. So, that piece around people are still looking, the researchers are working hard and that even if you don't have a diagnosis today you might get one in the future. Lindsay talked about your sample being dusty and not being looked at. I think it gives lots of families, not just those that get this diagnosis but all of those that haven't got a diagnosis, hope, that hopefully in the future they will get a diagnosis. I think one of the things we really hope will come out of diagnoses like this is that we will then be able to build up more of that picture about how families are affected. So, that we can give families more information about not only how their child is affected but how they might be affected in the future. That prognosis information that Linsday said is really missing when you don't have a diagnosis. And I think the other thing that hopefully is the next stage in this journey with this discovery is that those two science publications that Emma talked about, what we will want to do here at Unique working with the researchers and those families that have got a diagnosis, is to produce a patient family friendly information leaflet about this condition. One of the things we know is really important about those patient leaflets is including the photos. Because as both Emma and Lindsay have said that idea that they have facial features in common. And so, if you look at a leaflet and you can recognise your child in it, and you can see others that look like it, that can be a really sort of quite heartwarming experience in what often is a lonely experience with a rare condition. Naimah: And I think kind of on that point about it being a lonely experience, I wondered Lindsay if you could talk a bit more if this research has allowed you to connect with other parents and families who have received a diagnosis, and what impact that's had on your family? Lindsay: Yeah. I mean, and I think everything that Sarah has said was spot on. It's wonderful to have resources like Unique to connect families and have those diagnoses on the platform, so other clinicians can look for it and sort of grow this group. I think that has definitely been the highlight of getting this diagnosis at this stage, right. Because there's not much more you can do with it, with someone so brand new so being able to connect with the other families has been wonderful. One amazing mum who with this diagnosis set up a Facebook group, RNU4-2 Family Connect. And, you know, it's just been amazing to see people from all over the world joining this as they receive this diagnosis, you know, sharing their stories. We've spent countless hours on the weekends over the past couple of months on Zoom calls with total strangers, but just you find that you can just talk for hours and hours because you have so much in common. It's great to see what has worked well for other families and, you know, what has not worked. Sharing resources, just kind of all learning together. Also seeing the spectrum of this diagnosis, I think most genetic disorders have a spectrum and this seems to be the same here. So, that's been very interesting. And of course, our son is 8, Lars is 8. There's now a 33-year-old and a 29-year-old in the Facebook group. Speaking for me personally it's just amazing to see them and like it's very cool to see where they're at. That sort of helps you answer some of those questions about that before were quite unknown when you were thinking about the future. Obviously, everybody's development whether you have a genetic disorder or not, it is going to be what it's going to be, and everybody is going to do their own thing. But being able to see what a path might look like is just so helpful. And, you know, we all want community and connection, and so this has been really, really great to have that now. Sarah: I don't think there's much more that I can add because Lindsay articulated so well. But it's really heartwarming for us to hear the benefits of those connections because that's really why Unique and other support groups exist. Is to provide, partly to provide information, but I think predominantly to put families in touch with other families so that they can find a new home and connect and share experiences. And, you know, stop feeling as alone as they might have done before. Naimah: Okay, we'll wrap up there. Thank you to our guests, Lindsay Pearce, Sarah Wynn and Emma Baple for joining me today as we discussed the research findings which found a genetic change in the RNU4-2 gene which has been linked to neurodevelopmental conditions. If you'd like to hear more like this, please subscribe to Behind the Genes on your favourite podcast app. Thank you for listening. I've been your host and producer, Naimah Callachand, and this podcast was edited by Bill Griffin of Ventoux Digital.

Send us a Text Message.Host: Brandon WelchCo-Host: Brad Parse of simplifiedsales.comExecutive Producer: Carter BreauxAudio/Video Producer: Nate the Camera GuyOur Website: https://frankandmaven.com/Instagram: https://www.instagram.com/frankandmavenmarketing/TikTok: https://www.tiktok.com/@frankandmavenTwitter: https://twitter.com/frankandmavenLinkedIn: https://www.linkedin.com/company/frank-and-maven/Do you have a marketing problem you'd like us to help solve? Send it to MavenMonday@FrankandMaven.com!Get a copy of our Best-Selling Book, The Maven Marketer Here: https://a.co/d/1clpm8a

Send us a Text Message.Padraic Pearse was an Irish teacher, lawyer, poet, writer, nationalist, republican political activist and revolutionary who was one of the leaders of the Easter Uprising in 1916. Following his execution along with fifteen others, Pearse came to be seen by many as the embodiment of the rebellion.  My Father, brother Steve and I got to tour his summer cottage in Ireland on our last visit.  I was able to pick up a couple books while there.  He and the other leaders of the Uprising are cherished in my heart.Support the Show.Irish Mythology - Mythical Cycle - Book of Invasions

In this episode of the Off-Road Racer Podcast, I sit down with Pearse Umlauf, CEO and President of Jeep Jamboree USA, a company that hosts 50+ off-road events a year, both domestically and internationally and has been instrumental in keeping the legendary Rubicon trail open for all to enjoy. Pearse and I discuss the company's history and its founder, Mark A. Smith, who was inducted into the Off-Road Motorsports Hall of Fame in 1979. Coming into the present, we talk about some of the company's current projects and the freedom the company maintains as a family-owned business. Pearse and I also talk a lot about the current state of the Jeeping community, focusing a lot on the constant battle to keep public land open to off-road vehicles, and how the release of the 4-door Wrangler has changed the Jeeping scene. Wrapping up, we talk about the effect off-roading has on your psyche and the importance of overcoming challenges. I'm your host Matt Martelli, and this IS the Off-Road Racer Podcast.

SummaryWant to know how VCs pick founders to back or not? Join us as Pearse Coyle of Deepseed Fund VC shares insights on deep tech startups, venture capital due diligence, and more. If you're a startup looking for funding, this video is a must-watch!Takeaways1. Market discovery is crucial for startups to identify potential customers and validate their product or service.2. Cap table issues often arise in university spinouts, with tenured academics expecting a larger stake than full-time founders.3. A standardized scorecard can help evaluate startups based on market traction and customer interest.4. Investors should look for startups that have engaged customers and a clear path to market.Building a strong founding team is crucial for startups and spin-outs. It requires the commitment of the scientists or entrepreneurs involved and the involvement of individuals who are familiar with the technology.5. Measuring traction in startups can be challenging, especially in deep tech ventures. It is important to define tangible stages in the sales process and track the progress of potential customers.6. Becoming a VC in the deep tech space requires experience and understanding of the investment process. It is recommended to gain a track record through angel investing or successful entrepreneurship.7. The deep tech sector is expected to shape the future of technology and innovation. With the potential decline in the software business, there will be a shift of capital towards deep tech ventures, leading to new opportunities and challenges for the VC industry.Chapters00:00 Trailer 01:12 Introduction / Venture Investing and Consulting22:33 What kind of cap table screw up and importance of scorecard?33:04 Building a Better Founding Team41:03 What matrics are used to evaluate startups 47:45 Becoming a VC in the Deep Tech Space46:14 Measuring Traction in Startups53:55 Becoming a VC in the Deep Tech Space55:35 Emerging Trends in the Deep Tech Sector01:01:03 Ritual Time ( What's the worst decision he made )01:02:31 Ending Connect with Mudassir

In this week's Shattered Lives, Paul and Mick discuss a packed week of crime stories - from the death of evil Garda killer Pearse McAuley to a drugs bust in Cork, a former Garda jailed, a major breakthrough in the Ken Fetherston case and an infamous rapist issuing us threats Learn more about your ad choices. Visit megaphone.fm/adchoices

Paul Reynolds, Crime Correspondent, reports that convicted garda killer Pearse McAuley has been found dead at his home in Strabane in Co Tyrone.

James Pearse Connelly http://jpconnelly.com/ https://www.instagram.com/jpconnelly/ ---- CREDITS Thanks to Yoni Wolf and the band WHY? for our theme music. Thanks to my man Nate Utesch and his band Metavari for all the other tunes! soundcloud.com/metavari Thanks to Alex Sugg for editing and the podcast! www.alexsugg.com

The gang at The Produce Stand are joined by Allie Pearse, who is a writer on Letterkenny and also plays Alex.