Change of object's surface through age and exposure
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Back again to the podcast, Danny Stucker has been a car guy since he was old enough to hold a wrench, and since my latest addiction of buying and restoring Fords of all shapes and sizes, Danny has been a key motivator of all of the "outside my comfort zone" repairs over the last few years. Danny, welcome back to Ford Mustang: The Early Years Podcast.Do you own an early-year Mustang?YesHow long have you owned your ride?Yes, since 2020If you've made improvements to your classic car or restored it, what work have you done?Complete driveline upgrades and built a performance 6 cylinder 200What plans do you have for improvements/restoration/modification of your classic car?Coil over suspension Connect with the show:@mustangpodcasthttps://www.instagram.com/mustangpodcast/Connect with Dougdoug@turnkeypodcast.com Interested in renting your Classic Ride for photo shoots?ClassicFordRentals.comGot a classic Ford in SoCal? A Mustang. F-Series, or Classic Falcon or Galaxy? Survivor? Showing lots of Patina? Or a Show truck. I'm looking to put real classics on real sets — photo shoots, commercials, film, and premium productions. You keep your ride. I handle the clients, bookings, and logistics. Turn your classic Ford into a paid, on-camera icon.Visit ClassicFordRentals.com, scroll to the bottom of the page, and share your info with me— let's get your truck or Mustang working.Want to be a guest on the show?Send an email to me: doug@TurnkeyPodcast.com Sponsored by: National Parts Depotwww.npdlink.comWith 4 warehouses nationwide, you'll get your parts fast!"Keep it safe, keep it rollin', and keep it on the road. Until next time!" Doug Sandler
The Patina each fights their own flavor of battles - Birdie's is with kettle corn. Cast: - Marathon Messenger is played by Penn Van Batavia. She can be found on Twitter at @acquiredchaste and in drag as horror king JOHN on Instagram at @john.is.risen. Penn is an indie TTRPG designer whose most recent work includes SLICE *IT* OUT, a grisly carving RPG about cutting pieces of yourself out to fit in. Check out faer other work at pennharper.itch.io. - Cassidy Shard is played by Sydney Whittington. She is our wonderful editor. She's also a contributing editor and occasional guest player for the Orpheus Protocol, a cosmic horror espionage actual play podcast. Find her on Twitter at @sydney_whitt. - Emma Blackwood is played by Cameron Robertson. Find her on Twitter at @midnightmusic13 and on Instagram at @reading_and_dreaming. Cameron is also a player on Tabletop Squadron, a Star Wars Edge of the Empire actual play podcast. - Birdie Foundling is played by Kit Adames. Find her on Twitter at @venusvultures. Kit is also a voice actor and writer on Elevator Pitch Podcast, a queer genre-hopping anthology podcast that can be accessed on Spotify and YouTube. - Our GM and narrator is Nick Robertson. Find him on Twitter at @alias58. Nick is also the GM for Tabletop Squadron and can also be found as a player on the Orpheus Protocol. Music & Sound Credits: - This podcast features the musical talents of Dora Violet and Arne Parrott. You can find Dora at facebook.com/doraviolett. You can find Arne at atptunes.com. - old radio Channel search sound effect by Garuda1982. Link & License. - Paused Organ by thedutchmancreative. Link & License. - SFXsource.com-free-heartbeat-sound-effect.mp3 by SFXsource.com. Link & License. - WALLA Ballpark Applause Short 05 by AshFox. Link & License. - Dripping (Zoom) » Dripping, Slow, A.wav by InspectorJ. Link & License. - Happy Greece Traveling (ID 1339) by Lobo Loco. Link & License. - Death Valley (ID 1001) - Remastered by Lobo Loco. Link & License. Art Credits: - The official artwork for this podcast was created by Rashed AlAkroka, who can be found on Instagram and Artstation @rashedjrs. Find Us Online: - Our Website - Twitter - Join our Patreon - Join our Discord
In der heutigen Podcast-Folge sind wir zu Gast ganz in der Nähe des Schleizer Dreiecks – bei Robert von Edelweiß Customs.Wenn ihr Patina, Staub und Originalzustand als Kunst betrachtet und originalen Lack einem frisch lackierten Motorrad oder Auto immer vorzieht, dann seid ihr bei Robert genau richtig. Seine Zweiradsammlung erzählt Geschichten aus teils über 100 Jahren. Doch wie kommt man dazu? Und was lernt man eigentlich im Studiengang „Restaurierung von Kulturgut“? Wir sprechen über den Druck großer Projekte und den ganz eigenen Ansatz beim Restaurieren des Team von Edelweiß Customs. Hier wird Patina auch mal so perfekt nachgebildet, dass sie manchmal fast echter aussieht als die tatsächlich entstandene. Wie ist Edelweiß Customs entstanden? Warum sind Fahrzeuge in schlechtem Zustand oft schwieriger zu finden als solche in gutem? Wie viele automobile Einhörner hat Robert schon entdeckt? Und ist er vielleicht sogar der Gründer von Kleinanzeigen? Das alles hört ihr in dieser Podcast-Folge.
Jim Foster has owned his Mustang for nearly 50 years, and in that time, the car has become far more than just transportation. Nicknamed “DABEEST,” this Mustang has survived hundreds of thousands of miles, an engine rebuild after 450,000 miles on the road, a serious accident, and a full restoration that brought it back to life in 2008.On this episode of Ford Mustang: The Early Years Podcast, James shares the stories behind decades of ownership, the upgrades that made the biggest difference, and what it's like staying connected to the same classic car through so many chapters of life. If you've ever wondered what makes someone keep a Mustang for half a century, this conversation delivers the answer.SnapshotEarly Mustang owner for almost 50 yearsOwns a Mustang named “DABEEST”Not in the restoration or Mustang parts businessLongtime enthusiast with a deep personal history tied to the carMajor Work CompletedRebuilt the engine after putting approximately 450,000 miles on the carAdded:Shorty headersEdelbrock 600 CFM carburetorUS MAG wheels/rimsThe car was involved in an accident in 2006Restoration completed, and the car returned in 2008www.dabeest.comConnect with the show:@mustangpodcasthttps://www.instagram.com/mustangpodcast/Interested in renting your Classic Ride for photo shoots?ClassicFordRentals.comGot a classic Ford in SoCal? A Mustang. F-Series, or Classic Falcon or Galaxy? Survivor? Showing lots of Patina? Or a Show truck. I'm looking to put real classics on real sets — photo shoots, commercials, film, and premium productions. You keep your ride. I handle the clients, bookings, and logistics. Turn your classic Ford into a paid, on-camera icon.Visit ClassicFordRentals.com, scroll to the bottom of the page, and share your info with me— let's get your truck or Mustang working.Want to be a guest on the show?Send an email to me: doug@TurnkeyPodcast.com Sponsored by: National Parts Depotwww.npdlink.comWith 4 warehouses nationwide, you'll get your parts fast!Email Doug: doug@turnkeypodcast.com"Keep it safe, keep it rollin', and keep it on the road. Until next time!" Doug SandlerRent your Classic Ford for commercials, film and special eventswww.ClassicFordRentals.comSign up today free of charge
Welcome back to Travel Stories with Moush and what a way to kick off Season 7! For our very first episode, I am joined by Meerah Ketait, Head of Retail & Leisure at dnata Travel and one of the most influential voices in the travel industry in this part of the world. With years of experience curating extraordinary journeys for all kinds of travelers, Meerah doesn't just know travel, she lives it. From family getaways to once-in-a-lifetime adventures, she brings it all to the table in this conversation. Episode Highlights & Destination Gems: 1. The Maldives - Not just a Honeymoon Destination. Meerah says that the Maldives is for everyone - families, couples, solo travellers and groups. • Beach villas offering covered, private access - ideal for families seeking privacy • Kids clubs catering to all age groups, from toddlers to teens • Options for every budget - from Hard Rock Maldives to Ritz Carlton and Patina • Just a 4-hour flight from Dubai - perfect for long weekends and short Eid breaks 2. Japan – A Once-In-a-Lifetime Destination. Over 37 million tourists visited in 2025, with forward bookings already being made 1-2 years in advance • Cherry blossom season in March is peak time, book ASAP or risk missing it entirely • Classic itinerary: Tokyo (world-class shopping) → Kyoto (bamboo gardens, temples) → Osaka → bullet train experience • Rich in culture, history, culinary depth and cutting-edge innovation 3. Aurora Lights / Northern Lights — THIS(2026) Is the Year! The solar cycle peaks in 2026, meaning Aurora frequency is at its absolute maximum RIGHT NOW. • The next peak won't be until the 2030s, so if it's on your bucket list, the time is now • Book as early as possible for winter departures coz availability is filling up fast 4. Uganda & Rwanda – Gorilla Trekking A physically demanding but life-changing experience, hiking through rainforests to spot gorillas in their natural habitat. • Suitable for ages 15 and above • Not your typical holiday but one that will shift your perspective on the world entirely 5. Kenya – The Great Migration Witnessing millions of animals migrate across the wild is a truly once-in-a-lifetime natural experience. • A bucket list moment for wildlife enthusiasts. 6. Gulf Cruises - The Perfect Introduction to Cruising Top recommendation for first-time cruisers - start with a Gulf cruise. • Ports include Abu Dhabi, Doha and Bahrain — close to home, familiar, and a great way to experience life on a moving hotel • Ideal for families, groups and couples alike 7. South Africa - Underrated & On the Rise One of dnata's top-selling international summer destinations in 2025. • Incredible value for money. Cape Town has an amazing coastline, world-class safaris and game drives • A destination for every budget, with outstanding food 8. Morocco - Quiet Luxury Meets Vibrant Culture Bustling souks in Marrakech to ultra-luxe resorts like Royal Mansour. • The Atlas Mountains, stunning beaches and rich cultural flavours • A destination that is deeply underrated and deserves far more attention 9. Thailand — The Ultimate Culinary Destination • From Michelin-starred restaurants to family-run street food stalls • Night markets, food markets and dining-led itineraries make this a foodie's paradise 10. Italy - The Soul of Slow Food Rome and Florence both deliver equally on culinary richness • dnata curates dedicated culinary itineraries like pasta-making classes, dough-rolling sessions and cooking with local Italian grandmothers 2026 is the UAE Year of Family and the team at dnata Travel are making it their mission to help families make the most of it. Connect with dnata Travel: www.dnatatravel.com https://www.instagram.com/dnatatravel/ https://www.facebook.com/dnatatravel https://www.linkedin.com/company/dnatatravelgroup/ https://www.youtube.com/@dnatatravel Thank you for tuning in to the Season 7 premiere of Travel Stories with Moush. If you loved this episode, please hit subscribe on your favorite podcast platform and leave us a rating or review - it truly helps us reach more travelers like you. Drop a comment and tell us which destination from today's episode is going straight to your bucket list? Stay connected with me on https://www.instagram.com/moushtravels/ to find out who's joining me next week. Explore all past episodes and destinations here: https://podcasts.apple.com/ae/podcast/travel-stories-with-moush/id1691525895 https://open.spotify.com/show/1pAUXiXuRLv1E9WFznWm7T?si=qA_E3Cf8RqKT97pUJcINxQ https://www.youtube.com/@travelstorieswithmoush Until next time…safe travels and keep adventuring. "Want a spotlight on our show? Visit https://admanager.fm/client/podcasts/moushtravels and align your brand with our audience."Connect with me on the following:Instagram @moushtravelsFacebook @travelstorieswithmoushLinkedIn @Moushumi BhuyanYou Tube @travelstorieswithmoush Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
As the city recovers and works to resume normal life, the Patina take a moment to discuss their epic victory and continue recovery. Cast: - Marathon Messenger is played by Penn Van Batavia. She can be found on Twitter at @acquiredchaste and in drag as horror king JOHN on Instagram at @john.is.risen. Penn is an indie TTRPG designer whose most recent work includes SLICE *IT* OUT, a grisly carving RPG about cutting pieces of yourself out to fit in. Check out faer other work at pennharper.itch.io. - Cassidy Shard is played by Sydney Whittington. She is our wonderful editor. She's also a contributing editor and occasional guest player for the Orpheus Protocol, a cosmic horror espionage actual play podcast. Find her on Twitter at @sydney_whitt. - Emma Blackwood is played by Cameron Robertson. Find her on Twitter at @midnightmusic13 and on Instagram at @reading_and_dreaming. Cameron is also a player on Tabletop Squadron, a Star Wars Edge of the Empire actual play podcast. - Birdie Foundling is played by Kit Adames. Find her on Twitter at @venusvultures. Kit is also a voice actor and writer on Elevator Pitch Podcast, a queer genre-hopping anthology podcast that can be accessed on Spotify and YouTube. - Our GM and narrator is Nick Robertson. Find him on Twitter at @alias58. Nick is also the GM for Tabletop Squadron and can also be found as a player on the Orpheus Protocol. Music & Sound Credits: - This podcast features the musical talents of Dora Violet and Arne Parrott. You can find Dora at facebook.com/doraviolett. You can find Arne at atptunes.com. - old radio Channel search sound effect by Garuda1982. Link & License. - Breezy city amb.wav by patchen. Link & License. - Hopefully (ID 515) by Lobo Loco. Link & License. - His Last Share of The Stars by Doctor Turtle. Link & License. - Remember Alexis Zorbas (ID 1340) by Lobo Loco. Link & License. Art Credits: - The official artwork for this podcast was created by Rashed AlAkroka, who can be found on Instagram and Artstation @rashedjrs. Find Us Online: - Our Website - Twitter - Join our Patreon - Join our Discord
Yesterday, we officially turned the page and hit 86,000 members in the group. Let that sink in for a minute — 86,000 people united by classic trucks, blue-collar roots, faith, family, hard work, and the passion for C10 culture. To put that into perspective, over the weekend there was a George Strait concert that reportedly had around 72,000 people in attendance for one night… and C10 America just crossed 86,000 members strong. That's absolutely incredible and something every member of this community helped build together. Today we'll be talking about: The explosive growth of C10 America The road to 100,000 members by the end of the year Upcoming truck shows and events Scott's White Buffalo Car Show this weekend Future plans for the community, podcast, and magazine Vendors, sponsors, and advertiser opportunities Supporting the blue-collar truck culture that keeps this movement alive We'll also be sharing the awesome commercial written and produced by Roller for Scott's White Buffalo Car Show, so if you want to learn more about the event and the people behind it, make sure you tune in. C10 America continues to grow because of YOU. Every invite, every share, every post, every story, and every truck photo helps push this movement forward. We appreciate every single member who believes in what we're building here. If you'd like to support the cause, you can: Share the podcast and livestream Invite friends into the group Spread the word about C10 America Support the vendors and advertisers who support the community Donate to help us continue growing and building bigger things ahead We're always looking for new vendors, advertisers, and businesses that want to connect with one of the fastest-growing truck communities online. If you'd like to advertise with C10 America or want more information about the commercials featured during the show, contact us directly:
Adam's Polishes: https://adamspolishes.com/How have we not met until now -- and only then via coincidence. Mustangs, F-100s, and a laundry list of acquaintances in common.Adam Pitale is the kind of guy who's been obsessed with making things shine since he was a kid—literally starting by cleaning and polishing bikes as a pre-teen. That obsession turned into a hustle, then a business, and eventually into what we now know as Adam's Polishes. He launched it back in 2000 in California, not from some grand plan, but because he needed to make a living—and figured there had to be a better way to keep things looking perfect.Today, Adam's built a global brand around that same mindset: a little obsessive, a little unconventional, and completely driven by doing things better than “good enough.” He's the guy who'd rather wash a forklift—or Classic Ford —than let it stay dirty… and that pretty much tells you everything you need to know about how he shows up in business. I coincidentally connected with Adam when I saw he was recently selling a classic Ford truck on Marketplace. Which I must add did finally close. Adam, welcome to the podcast.I have at least a half dozen of your products sitting in my garage right now -- coincidence? I think not.Adam's Polishes https://adamspolishes.com/Enzo's Hand Wash and Detail: https://www.enzoshandwash.com/Connect with the show:@mustangpodcasthttps://www.instagram.com/mustangpodcast/Interested in renting your Classic Ride for photo shoots?ClassicFordRentals.comGot a classic Ford in SoCal? A Mustang. F-Series, or Classic Falcon or Galaxy? Survivor? Showing lots of Patina? Or a Show truck. I'm looking to put real classics on real sets — photo shoots, commercials, film, and premium productions. You keep your ride. I handle the clients, bookings, and logistics. Turn your classic Ford into a paid, on-camera icon.Visit ClassicFordRentals.com, scroll to the bottom of the page, and share your info with me— let's get your truck or Mustang working.An Expert's Guide to Maintaining Your Classic Mustangwww.TheMustangPodcast.com/repairSponsored by: National Parts Depotwww.npdlink.comWith 4 warehouses nationwide, you'll get your parts fast!Email Doug: doug@turnkeypodcast.com"Keep it safe, keep it rollin', and keep it on the road. Until next time!" Doug Sandler
Eine neue Review ist im Kasten und wird schon bald euren Algo flooden - ...also hoffentlich! Passend dazu hat Jan den allerechten Grafen und bekanntermaßen besten Industry Buddy des Crazy Frogs auf Tour besucht: grim104! Er berichtet von wilden Twists der Setlist, uriger Bühnen-Deko und einem illustren Gäst:innen-Line-Up! Und wie es der Zufall will, hat Eric auch direkt die perfekten neuen Releases aus unserer Bubble gehört: Nicht nur verbreitet grim104-Support-Act Katanna mit ihrer Bande Patina Records wieder neues wohlgeformtes Chaos, auch Baran Kok, Samara Cyn und Fcukers wühlen ihre jeweiligen Szenen auf! Wir wünschen euch viel Spaß mit diesem Vorgespräch und versprechen euch nicht zu viel, wenn wir sagen: Die »No Country for Old Grim«-Folge wird absolut Peak-FWC! LG und 1000 Dank für euren Support!
Welcome to Facebook Live Audio Edition 5.5.26—this is the audio side of what went down live, cleaned up and ready to roll. We're breaking in the new format today—no more reading ads live. You'll hear our commercials dropped in the way they're supposed to be—tight, professional, and built to keep the show moving. It saves time and keeps us locked into that one-hour window without losing the flow. If you want the full experience, head over to the C10 America Facebook page and watch the live version. This right here is for the guys on the go. We're talking upcoming shows, where C10 America will have a booth, where we'll just be walking and connecting, and a few stops we won't be making. And yeah—we get into some “street walking, street talking”… you'll want to hear which show that's about. And by the way—if you like what you're hearing with our ads, we can do the same thing for you. Whether you're starting a podcast, building a TikTok, launching a YouTube channel, or growing a Facebook page—we'll help you sound polished and professional right out of the gate. Doesn't matter where you're at—another state, another town, or even another country—we've got you covered. Just send us a little info about your business or what you're building, and we'll turn it into a clean, high-quality audio commercial that fits your style. There's a small fee, but if you're serious about your content, it's worth it. Real trucks. Real people. Real conversations. C10 Keywords:Hashtags:
Heute gibt es für euch die Runde mit Calli!
Today on Ford Mustang: The Early Years Podcast, we're talking legacy—real legacy. Our guest has been riding in the same Mustang since 1966… yeah, you heard that right. Bought new by his mom, it officially became his in 1980, and over the decades, it's evolved into something far beyond stock—rebuilt from the ground up with just a couple of original pieces still hanging on.He's called it The Mistress, The Beast, and the Hot Rod… and once you hear this story, you'll understand why.If you love long-term ownership, serious transformation, and the kind of Mustang story you just can't replicate today—this one's for you. Let's get into it. David Gast, welcome to the podcast.Ford Mustang, The Early Years Podcast -- Guest Interview Application============Do you own an early-year Mustang?Yes.If you own a Mustang, how long have you owned your ride?Mom bought it new. I have been in it since 1966, 60 years. It became mine around 1980.If you own a Mustang or classic car, have you named your car? If so, what is his/her name?She has been called The Mistress, The Beast, and the "Hot Rod" among other names over the years.If you've made improvements to your classic car or restored it, what work have you done? Drivetrain, Body, Interior, suspension, brakes. I think the only original parts are the rear end housing and the passenger door.What plans do you have for improvements/restoration/modification of your classic car?EFI, perhaps.Connect with the show:@mustangpodcasthttps://www.instagram.com/mustangpodcast/Interested in renting your Classic Ride for photo shoots?ClassicFordRentals.comGot a classic Ford in SoCal? A Mustang. F-Series, or Classic Falcon or Galaxy? Survivor? Showing lots of Patina? Or a Show truck. I'm looking to put real classics on real sets — photo shoots, commercials, film, and premium productions. You keep your ride. I handle the clients, bookings, and logistics. Turn your classic Ford into a paid, on-camera icon.Visit ClassicFordRentals.com, scroll to the bottom of the page, and share your info with me— let's get your truck or Mustang working.An Expert's Guide to Maintaining Your Classic Mustangwww.TheMustangPodcast.com/repairSponsored by: National Parts Depotwww.npdlink.comWith 4 warehouses nationwide, you'll get your parts fast!Email Doug: doug@turnkeypodcast.com"Keep it safe, keep it rollin', and keep it on the road. Until next time!" Doug Sandler
Repasamos la derrota del Atlético de Madrid ante el Elche (3-2) y repasamos el día después de la victoria del Real Madrid, marcada por los pitos a Vinícius y al resto del equipo, con Álvaro Benito.
FOLLOW UP: EU INDUSTRIAL ACCELERATOR ACT THREAT TO UKWe last covered this story on the episode Its talcum powder - 10 March 2026, but more have noticed the huge threat the ‘Made in Europe' element is to the UK automotive industry. The Society of Motor Manufacturers and Traders (SMMT) has become increasingly vocal in its warnings. As it stands cars and parts made in the UK would not receive the incentives those made in the EU would. To read more, click this EV Powered article link here.AUTOCAR GREAT WOMEN 2026Autocar held their Great Women 2026 event last week, where the winners were announced for a variety of categories showcasing the breadth and depth of the talent, quality and excellence that is brought to the automotive world. Lisa Brankin, Managing Director and Chair of Ford UK & Ireland, won the overall award. Click this link here, to find out more about the event. Then click this link here, to see all the categories, nominees and winners.CUSTOMERS CAN TAKE ARNOLD CLARK TO COURTArnold Clark suffered a cyber attack in 2022 that resulted in customer data being available to anyone on the internet. The company has tried to argue that it should not face a claim in a Scottish court as they were already doing so in England. The highest court in Scotland rejected this argument as people had bought their cars in Scotland and this case was not connected to England. You can find out more, by clicking this Yahoo!News article link here.STELLANTIS TO END CAR PRODUCTION AT POISSY FACTORYStellantis has announced that it will be winding down car production at it's Poissy factory, in France, from 2028. Once this is completed the site will still make parts for other Group sites. To read more, click this electrive article link here.VW WRITES-DOWN $500M IN US BUSINESSVolkswagen has had to write-down $500 million due to the cancellation of the production of the ID.4 at their Chattanooga factory, in the US. This comes after pausing the production line when the US Government cancelled the previous administration's EV subsidies, causing sales to plummet. If you wish to find out more, click this article link from electrive, here.NISSAN SEEKING PRODUCTION PARTNER FOR SUNDERLANDNissan's Sunderland plant is running at about 50% capacity currently and is seeking to sub-let that spare capacity to another brand. Discussions are ongoing with Chery and Dongfeng. For more on this, click the link here to an electrive article.STELLANTIS PARTNER WITH MICROSOFTStellantis has partnered with Microsoft, who will be providing their software and AI to allegedly assist the group in becoming more efficient and better, as well as offering customers supposed improvements to their car ownership. You can read more by clicking this CarScoops article link here.On Thursday 23 April at 20:00 BST, we will be going live with a Q&A on our YouTube channel. We need your help though, send us your automotive and motoring related question you would like to hear us answer. To send one in use our Contact Page, linked to here, and put “Q&A” in the Subject Line so it does not get lost in all the spam.NEW NEW CAR NEWS -Nissan JukeNissan shocked everyone with the reveal of their radical looking next generation Juke, which will be all electric. Taking its cues from the Hyper Punk concept of last year, this is a stylised vehicles with lots of sharp angles to the bodywork. Click this Autocar article to read more.Volkswagen ID.3 NeoThe VW ID.3 is being updated once again and this time it also partially gets a name, Neo. The exterior is recognisably close to the previous version but the interior gets upgrades, including adding buttons to the dash and steering wheel. Materials will also be of higher quality and better feel. Click this Autocar article for more.Denza Z9 GTDenza is a new to the UK brand from BYD and they are bringing a £100,000 performance EV. Technical specs include an 122kWh battery pack and triple electric motors producing 1140bhp, enabling a 0-62mph time of 2.7 seconds. The car will get access to BYD's Flash charging network once it is up and running. Click this Autocar article for more.DESIGNERS MOOD BOARD: KEMEL CURIC WILL LEAD MCLAREN'S DESIGNKemel Curic has been announced as the new head of design at McLaren. He joins at a time when the brand is trying to reinvent itself. He leaves Ford, more specifically Lincoln, where he was working. You can read more by clicking this Autocar article link here.LUNCHTIME WATCH: RUSTIVAL 2026To help yours and our FOMO, if you didn't get to it, we are linking to four videos about Rustival 2026. We have picked the three channels that helped organise the event and one more, but do search YouTube for Rustival 2026 and spread some love to those who aren't linked below.Click this link here for Steph's I Drive a Classic channel's video.To see what Furious Driving's video is like, click this link here.HubNut produced a slightly different video, giving us a peak at what it takes to put on the event. Click this link here to see that.Click this link here for Jon Coupland's take on the day.LIST OF THE WEEK: HERE ARE OUR NINE FAVOURITE OFF-ROAD ESTATESTop Gear, once again, has a cracking list for you to check out. Do you agree with Alan's choice? Which of the nine would you pick? Click this link here to see what the options are.AND FINALLY: COME FEEL THE NOISEThis week we effectively give you another Lunchtime Watch, with Mr Patina beginning the restoration process of a classic Renault 4. Do sit back, relax and enjoy some ASMR restoration. Click this link to watch.
In this podcast episode, Erika Hamilton, MD, FASCO, and Ian Krop, MD, PhD, discuss recent developments in the field of first-line therapy and maintenance treatment for patients with HER2-positive metastatic breast cancer, including the following: Trastuzumab deruxtecan plus pertuzumab as first-line therapy based on data from DESTINY-Breast09 Adding palbociclib to HP and ET as maintenance therapy for HR-positive/HER2-positive MBC, based on data from PATINA Adding tucatinib to HP as maintenance therapy for HER2-positive MBC, based on data from HER2CLIMB-05 Presenters: Erika Hamilton, MD, FASCO Chief Development Officer, Late Phase Director, Breast Cancer Research Program Sarah Cannon Research Institute (SCRI) Nashville, Tennessee Ian Krop, MD, PhD Professor of Medicine, Yale School of Medicine Associate Cancer Center Director for Clinical Research Yale Cancer Center New Haven, Connecticut Content based on an online CME program supported by an educational grant from Pfizer. Link to full program: https://bit.ly/4esvN9x Get access to all our new podcasts by subscribing to the Decera Clinical Education Oncology Podcast on Apple Podcasts, YouTube Music, or Spotify. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
The battle is heating up for the Patina and it's starting to take a toll. Cast: - Marathon Messenger is played by Penn Van Batavia. She can be found on Twitter at @acquiredchaste and in drag as horror king JOHN on Instagram at @john.is.risen. Penn is an indie TTRPG designer whose most recent work includes SLICE *IT* OUT, a grisly carving RPG about cutting pieces of yourself out to fit in. Check out faer other work at pennharper.itch.io. - Cassidy Shard is played by Sydney Whittington. She is our wonderful editor. She's also a contributing editor and occasional guest player for the Orpheus Protocol, a cosmic horror espionage actual play podcast. Find her on Twitter at @sydney_whitt. - Emma Blackwood is played by Cameron Robertson. Find her on Twitter at @midnightmusic13 and on Instagram at @reading_and_dreaming. Cameron is also a player on Tabletop Squadron, a Star Wars Edge of the Empire actual play podcast. - Birdie Foundling is played by Kit Adames. Find her on Twitter at @venusvultures. Kit is also a voice actor and writer on Elevator Pitch Podcast, a queer genre-hopping anthology podcast that can be accessed on Spotify and YouTube. - Our GM and narrator is Nick Robertson. Find him on Twitter at @alias58. Nick is also the GM for Tabletop Squadron and can also be found as a player on the Orpheus Protocol. Music & Sound Credits: - This podcast features the musical talents of Dora Violet and Arne Parrott. You can find Dora at facebook.com/doraviolett. You can find Arne at atptunes.com. - old radio Channel search sound effect by Garuda1982. Link & License. - gunshot.wav by mark646. Link & License. - catapult.wav by cetsoundcrew. Link & License. - artninja__custom_rock_impact_sound_pt4_03122026 by ArtNinja. Link & License. - The Beauty of Maths by Meydӓn. Link & License. - Principles in Action by David Hilowitz. Link & License. Art Credits: - The official artwork for this podcast was created by Rashed AlAkroka, who can be found on Instagram and Artstation @rashedjrs. Find Us Online: - Our Website - Twitter - Join our Patreon - Join our Discord
I et sommerhus midt i et øde område og klædt i masker indkalder Patina til rituelt møde. Formålet er for alt i verden at undgå klichéen om den svære toer. Men selvom de står med et næsten fuldendt album nummer to efter den tur, mangler der stadig noget. Den sang, der kan balancere mørket og bringe håbet ind. Og inden de kan forløse netop den mission, så er maskerne nødt til igen at falde for at nå ind til det rene og håbefulde. Nummeret "Genstart" bliver bandets genstart og skal senere vise sig at få sin helt egen genstart, da det pludseligt hitter som lyden af senior-dating. Gæster: Søren Bastrup Bojsen, Gregers Møller Jensen og Mads Skov Hansen Vært: Christine Milton Producer, Tilrettelægger og klipper: Robert Haugsted Lyddesigner: Jacob Tølbøll Zaulich Redaktør: Kasper Overby
Ander Iturralde da la bienvenida a Santiago Tomasi y Juandi Mata, además de a Óscar Portugal, para analizar toda la acción en el regreso de la Premier League... Comenzando por la psicológicamente cataclísmica derrota del Arsenal a manos del Bournemouth; la cual devolvió el poder al Manchester City de ganar la Premier League si gana todos sus partidos y se puso manos a la obra destruyendo al Chelsea; como al "nuevo" Tottenham de De Zerbi con un soplido y un sólo gol lo destruyó el Sunderland; mientras que de golpe a golpe y de área a área Nottingham Forest y Aston Villa sólo pudieron firmar un tratado de empate; pero no fue el caso del West Ham vapuleando con arrolladora contundencia al Wolverhampton; cosa que tampoco hizo a ese nivel pero sí que ganó igualmente un Liverpool de sinsabores al Fulham gracias a la aparición de un regateador en su equipo como Rio Ngumoha; para Brentford y Everton fue un partido de trepidante acción, de demostración de por qué son las dos grandes revelaciones de la temporada; algo que no han sido ni Burnley ni Brighton pero su partido lógicamente terminó con victoria de los segundos; mientras que el Crystal Palace fue quien marcó segundo y un segundo gol también para derrotar al Newcastle; en Championship, hubo un increíble surtido de todo un poco y de un Leicester camino del descenso a tercera división; un título para el Luton Town de Jack Wilshere y mucho más.Apoya que Alineación Indebida pueda prosperar, accede a todo nuestro contenido premium y a nuestro server de Discord suscribiéndote por tan sólo 1.00$/1.00€ en: https://www.patreon.com/posts/155470552Además... Ahora, al suscribirte en nuestra página de Patreon, puedes escuchar todo nuestro contenido de Alineación Indebida Premium a través del siguiente link de Spotify. Sólo tienes que vincular la cuenta que abras en Patreon y, a partir de ahí, tendrás desbloqueado todo el contenido premium que producimos: https://open.spotify.com/show/6WeulpfbWFjVtLlpovTmPv¡Volvemos el Jueves!Sigue a Ander: https://x.com/andershoffmanSigue a Tomasi: https://x.com/TomasiSantiagoSigue a Juandi: https://x.com/MataJdSigue a Óscar: https://x.com/OscarP107Sigue al programa en Twitter: https://twitter.com/PodcastIndebidoSigue al programa en Instagram: instagram.com/podcastindebidoContacto: anderpodcast@gmail.com // alineacionindebidapodcast@gmail.com Hosted on Acast. See acast.com/privacy for more information.
Do you own an early-year Mustang?Yes.How long have you owned your ride?4 years this past December.Have you named your car?Yes. I named her Merida from the Disney movie Brave. My license plate says BRVHRT ( Braveheart), and my last name is Wallace.If you've made improvements to your classic car or restored it, what work have you done?I upgraded the front suspension. I did the Shelby drop and installed GT springs. Wilsood disc brakes. I upgraded to a 9" rear-end with 3.55 gears. Replaced the 3-speed automatic transmission with a T-5.What plans do you have for improvements/restoration/modification of your classic car?None. I am completely finished. I even signed my glove box door.Connect with the show:@mustangpodcasthttps://www.instagram.com/mustangpodcast/Interested in renting your Classic Ride for photo shoots?ClassicFordRentals.comGot a classic Ford in SoCal? A Mustang. F-Series, or Classic Falcon or Galaxy? Survivor? Showing lots of Patina? Or a Show truck. I'm looking to put real classics on real sets — photo shoots, commercials, film, and premium productions. You keep your ride. I handle the clients, bookings, and logistics. Turn your classic Ford into a paid, on-camera icon.Visit ClassicFordRentals.com, scroll to the bottom of the page, and share your info with me— let's get your truck or Mustang working.An Expert's Guide to Maintaining Your Classic Mustangwww.TheMustangPodcast.com/repairSponsored by: National Parts Depotwww.npdlink.comWith 4 warehouses nationwide, you'll get your parts fast!Email Doug: doug@turnkeypodcast.com"Keep it safe, keep it rollin', and keep it on the road. Until next time!" Doug Sandler
The Patina is making progress on their objectives, but things are starting to get dangerous in the chaos. Cast: - Marathon Messenger is played by Penn Van Batavia. She can be found on Twitter at @acquiredchaste and in drag as horror king JOHN on Instagram at @john.is.risen. Penn is an indie TTRPG designer whose most recent work includes SLICE *IT* OUT, a grisly carving RPG about cutting pieces of yourself out to fit in. Check out faer other work at pennharper.itch.io. - Cassidy Shard is played by Sydney Whittington. She is our wonderful editor. She's also a contributing editor and occasional guest player for the Orpheus Protocol, a cosmic horror espionage actual play podcast. Find her on Twitter at @sydney_whitt. - Emma Blackwood is played by Cameron Robertson. Find her on Twitter at @midnightmusic13 and on Instagram at @reading_and_dreaming. Cameron is also a player on Tabletop Squadron, a Star Wars Edge of the Empire actual play podcast. - Birdie Foundling is played by Kit Adames. Find her on Twitter at @venusvultures. Kit is also a voice actor and writer on Elevator Pitch Podcast, a queer genre-hopping anthology podcast that can be accessed on Spotify and YouTube. - Our GM and narrator is Nick Robertson. Find him on Twitter at @alias58. Nick is also the GM for Tabletop Squadron and can also be found as a player on the Orpheus Protocol. Music & Sound Credits: - This podcast features the musical talents of Dora Violet and Arne Parrott. You can find Dora at facebook.com/doraviolett. You can find Arne at atptunes.com. - old radio Channel search sound effect by Garuda1982. Link & License. - Centerfire_Rifle_Gun_Shot_01.wav by MATRIXXX_. Link & License. - gunshot.wav by mark646. Link & License. - Wire explosions / vibrations (slow) by mlteenie. Link & License. - Barbed Wire.wav by Benboncan. Link & License. - Car Crash Elements Sideswipe 01 by PNMCarrieRailfan. Link & License. - custom_metal_crash_with_glass_debris_03022026 by Arttninja. Link & License. - Crash Mix Combine 02 by PNMCarrieRailfan. Link & License. - pile driver loop 02.wav by klankbeeId. Link & License. - wilhelm_scream.wav by Syna-Max. Link & License. Art Credits: - The official artwork for this podcast was created by Rashed AlAkroka, who can be found on Instagram and Artstation @rashedjrs. Find Us Online: - Our Website - Twitter - Join our Patreon - Join our Discord
Patina, what is it and why do we love it so much? Patina is the subtle change that develops on surfaces over time. It can happen to copper, brass, silver, wood, leather, and marble. SCHEDULE A DESIGN CONSULTNeed help with your home? We'd love to help! We do personalized consults, and we'll offer advice specific to your room that typically includes room layout ideas, suggestions for what the room needs, and how to pull the room together. We'll also help you to decide what isn't working for you. We work with any budget, large or small. Find out more HERECheck out Anita's Amazon shop HERE.Are you subscribed to the podcast? Don't need to search for us each Wednesday let us come right to your door ...er...device. Subscribe wherever you listen to your podcasts. Just hit the SUBSCRIBE button & we'll show up!XX,Anita & KellyDI - 9:14See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Today's guest is Jon Davis -- his can trace his Mustang roots back to the original owner. How cool would it be if we all could step into that time machine. Jon, welcome to Ford Mustang, The Early Years Podcast.Quick recap:In this episode of the Ford Mustang: The Early Years Podcast, host Doug interviewed John Davis about his 1965 Ford Mustang, which John purchased in 2011 from its third owner, John shared details about the car's history, including its assembly in San Jose, California in August 1965, and its original LA market specifications. The Mustang, which John affectionately calls "Pony," has been well-maintained with recent suspension work and brake repairs, though John prefers its unrestored condition with its patina and original parts.Connect with the show:@mustangpodcasthttps://www.instagram.com/mustangpodcast/Interested in renting your Classic Ride for photo shoots?ClassicFordRentals.comGot a classic Ford in SoCal? A Mustang. F-Series, or Classic Falcon or Galaxy? Survivor? Showing lots of Patina? Or a Show truck. I'm looking to put real classics on real sets — photo shoots, commercials, film, and premium productions. You keep your ride. I handle the clients, bookings, and logistics. Turn your classic Ford into a paid, on-camera icon.Visit ClassicFordRentals.com scroll to the bottom of the page and share your info with me— let's get your truck or Mustang working.An Expert's Guide to Maintaining Your Classic Mustangwww.TheMustangPodcast.com/repairSponsored by: National Parts Depotwww.npdlink.comWith 4 warehouses nationwide, you'll get your parts fast!Email Doug: doug@turnkeypodcast.com"Keep it safe, keep it rollin' and keep it on the road. Until next time!" Doug SandlerRent your Classic Ford for commercials, film and special eventswww.ClassicFordRentals.comSign up today free of charge
The Patina continues to hold back the mercenary incursion in a very distracting way while they work to get the city back on the move. Cast: - Marathon Messenger is played by Penn Van Batavia. She can be found on Twitter at @acquiredchaste and in drag as horror king JOHN on Instagram at @john.is.risen. Penn is an indie TTRPG designer whose most recent work includes SLICE *IT* OUT, a grisly carving RPG about cutting pieces of yourself out to fit in. Check out faer other work at pennharper.itch.io. - Cassidy Shard is played by Sydney Whittington. She is our wonderful editor. She's also a contributing editor and occasional guest player for the Orpheus Protocol, a cosmic horror espionage actual play podcast. Find her on Twitter at @sydney_whitt. - Emma Blackwood is played by Cameron Robertson. Find her on Twitter at @midnightmusic13 and on Instagram at @reading_and_dreaming. Cameron is also a player on Tabletop Squadron, a Star Wars Edge of the Empire actual play podcast. - Birdie Foundling is played by Kit Adames. Find her on Twitter at @venusvultures. Kit is also a voice actor and writer on Elevator Pitch Podcast, a queer genre-hopping anthology podcast that can be accessed on Spotify and YouTube. - Our GM and narrator is Nick Robertson. Find him on Twitter at @alias58. Nick is also the GM for Tabletop Squadron and can also be found as a player on the Orpheus Protocol. Music & Sound Credits: - This podcast features the musical talents of Dora Violet and Arne Parrott. You can find Dora at facebook.com/doraviolett. You can find Arne at atptunes.com. - old radio Channel search sound effect by Garuda1982. Link & License. - ExplosionBombBlastAmbientE.wav by Zimbot. Link & License. - "Ricochet" by ValhallaProject. Link & License. - gunshot.wav by mark646. Link & License. - Metal_heavy_punch_with_crunch_and_glass_debris_sounds_08242024 by Artninja. Link & License. - "Flag of No Country" by Julia Kent. Link & License. - Running Eiskrokodil (ID 01) - Remastered by Lobo Loco. Link & License. Art Credits: - The official artwork for this podcast was created by Rashed AlAkroka, who can be found on Instagram and Artstation @rashedjrs. Find Us Online: - Our Website - Twitter - Join our Patreon - Join our Discord
Episode 213 of the Down to Herf Podcast brings the heat as we sit down with Tyler Jeffery of Viso Horny to talk about one of the more unique collaborations to hit the cigar scene—Leprechaun Dust with Patina. We dive into the story behind the blend, how the partnership came together, and whether this limited release lives up to the hype once we put flame to it.Patrol Gone Wild is absolute chaos this week, featuring a delusional man posing as a diplomat, a spring break situation that spiraled completely out of control, and a criminal who got caught in a position that's as embarrassing as it is unbelievable.Caleb's News keeps you dialed in with the latest in the industry, including new release announcements from Crowned Heads and Dunbarton Tobacco & Trust. On the whiskey front, Remus is back with another drop that's got people talking.Cigar: Patina Y Viso Leprechaun DustA huge thank you to our show sponsors Crowned Heads Cigars, Dunbarton Tobacco And Trust, and Small Batch Cigars! Make sure you're checking them out for all of your cigar needs!Join The After Herf Show on Patreon Now!Patreon: https://www.patreon.com/DownToHerfPodcastVisit our Social Media Pages for News and More!Instagram: https://www.instagram.com/downtoherfpodcast/Facebook: https://www.facebook.com/downtoherfpodcast/Support the show
Got a classic Ford in SoCal? A Mustang. F-Series, or maybe a Classic Falcon or Galaxy? I'm looking to put real classics on real sets — photo shoots, commercials, film, and premium productions. I handle the clients, bookings, and logistics. And you get to turn your classic Ford into a paid, on-camera icon.Visit ClassicFordRentals.com, scroll to the bottom of the page, and share your info with me— let's get your truck or Mustang working.ClassicFordRentals.comEric RedingFrom what I can see from the pictures, today's guest is all about keeping it pure. His 1966 Wimbledon White Mustang Coupe with a 6-banger 200 under the hood is so clean you could just as easily see it on the showroom floor 60 years ago. Excited to talk. Eric Reding, welcome to the Ford Mustang: The Early Years podcast.Ford Mustang, The Early Years Podcast -- Guest Interview Application============Do you own an early-year Mustang?YesIf you own a Mustang, how long have you owned your ride?4 yearsIf you own a Mustang or classic car, have you named your car? If so, what is his/her name?The Old LadyIf you've made improvements to your classic car or restored it, what work have you done?Engine repaint; suspension refresh; cooling system repair; exhaust manifold replace; dual bowl install; under hood repair/repaint; so much tuningWhat plans do you have for improvements/restoration/modification of your classic car?Eventual interior door paint refresh; muffler replace; T5 maybe one dayConnect with the show:@mustangpodcasthttps://www.instagram.com/mustangpodcast/Interested in renting your Classic Ride for photo shoots?ClassicFordRentals.comGot a classic Ford in SoCal? A Mustang. F-Series, or Classic Falcon or Galaxy? Survivor? Showing lots of Patina? Or a Show truck. I'm looking to put real classics on real sets — photo shoots, commercials, film, and premium productions. You keep your ride. I handle the clients, bookings, and logistics. Turn your classic Ford into a paid, on-camera icon.Visit ClassicFordRentals.com, scroll to the bottom of the page, and share your info with me— let's get your truck or Mustang working.An Expert's Guide to Maintaining Your Classic Mustangwww.TheMustangPodcast.com/repairSponsored by: National Parts Depotwww.npdlink.comWith 4 warehouses nationwide, you'll get your parts fast!Email Doug: doug@turnkeypodcast.com"Keep it safe, keep it rollin', and keep it on the road. Until next time!" Doug SandlerRent your Classic Ford for commercials, film and special eventswww.ClassicFordRentals.comSign up today free of charge
Drs. Isaacs and Traina review how HER2CLIMB‑05 and PATINA challenge the old CLEOPATRA‑based approach by showing that adding tucatinib or palbociclib to maintenance therapy can extend progression‑free survival in metastatic HER2+ breast cancer. They stress tailoring maintenance regimens to each patient's hormone receptor status, CNS risk, and tolerance for side effects.
What makes a handbag truly worth carrying every day? We sit down with Shay Prasad of Bags for Breakfast to explore how years on the retail floor shaped her approach to bags as tools for life—not just status symbols. From writing deep-dive Substack essays to launching a curated vintage shop, Shay explains how storytelling, condition knowledge, and retail anthropology turn casual shoppers into thoughtful collectors. Along the way, she shares how to judge patina versus wear, why function matters as much as heritage, and how understanding the history behind iconic houses helps buyers make smarter, more sustainable choices.Key Takeaways: • Function beats fantasy — A great bag works with your real life. • Patina has value — “Loved” pieces often carry more character than pristine ones. • Context sharpens taste — Knowing a brand's history leads to better buying decisions.
The Patina charges into battle and begins wreaking havoc. Cast: - Marathon Messenger is played by Penn Van Batavia. She can be found on Twitter at @acquiredchaste and in drag as horror king JOHN on Instagram at @john.is.risen. Penn is an indie TTRPG designer whose most recent work includes SLICE *IT* OUT, a grisly carving RPG about cutting pieces of yourself out to fit in. Check out faer other work at pennharper.itch.io. - Cassidy Shard is played by Sydney Whittington. She is our wonderful editor. She's also a contributing editor and occasional guest player for the Orpheus Protocol, a cosmic horror espionage actual play podcast. Find her on Twitter at @sydney_whitt. - Emma Blackwood is played by Cameron Robertson. Find her on Twitter at @midnightmusic13 and on Instagram at @reading_and_dreaming. Cameron is also a player on Tabletop Squadron, a Star Wars Edge of the Empire actual play podcast. - Birdie Foundling is played by Kit Adames. Find her on Twitter at @venusvultures. Kit is also a voice actor and writer on Elevator Pitch Podcast, a queer genre-hopping anthology podcast that can be accessed on Spotify and YouTube. - Our GM and narrator is Nick Robertson. Find him on Twitter at @alias58. Nick is also the GM for Tabletop Squadron and can also be found as a player on the Orpheus Protocol. Music & Sound Credits: - This podcast features the musical talents of Dora Violet and Arne Parrott. You can find Dora at facebook.com/doraviolett. You can find Arne at atptunes.com. - old radio Channel search sound effect by Garuda1982. Link & License. - "Ricochet" by ValhallaProject. Link & License. - Parking Garage - Metal Door - Slam by soundadvices. Link & License. - Metal_heavy_punch_with_crunch_and_glass_debris_sounds_08242024 by Artninja. Link & License. - Won-t-Be-Stoppin by Ketsa. Link & License. - Whoosh by Crowander. Link & License. Art Credits: - The official artwork for this podcast was created by Rashed AlAkroka, who can be found on Instagram and Artstation @rashedjrs. Find Us Online: - Our Website - Twitter - Join our Patreon - Join our Discord
Jiunn, Seth and John discuss their blind review experience with the Patina Red Pill 5x54 BP https://developingpalates.com/reviews/cigar-reviews/team-cigar-review-patina-red-pill-5x54-bp/
The podcast episode featured Mike Clemens, who shared the story of his 1965 Fastback Mustang from the movie "The Bucket List." Mike explained how the car was purchased for the film and later sold, only to be reacquired 15 years later. He detailed the car's modifications for the movie, including a roll bar and square tube steel for the sideswipe scene. Mike also discussed his passion for classic Mustangs, having owned three similar cars before this one. The episode concluded with a discussion about the potential for renting classic cars for various productions and events.Bucket List Race Scene: https://youtu.be/mtZR_5sBqmI?si=XCZ_ZDlGypH18jqkConnect with the show:@mustangpodcasthttps://www.instagram.com/mustangpodcast/Interested in renting your Classic Ride for photo shoots?ClassicFordRentals.comGot a classic Ford in SoCal? A Mustang. F-Series, or Classic Falcon or Galaxy? Survivor? Showing lots of Patina? Or a Show truck. I'm looking to put real classics on real sets — photo shoots, commercials, film, and premium productions. You keep your ride. I handle the clients, bookings, and logistics. Turn your classic Ford into a paid, on-camera icon.Visit ClassicFordRentals.com, scroll to the bottom of the page, and share your info with me— let's get your truck or Mustang working.An Expert's Guide to Maintaining Your Classic Mustangwww.TheMustangPodcast.com/repairSponsored by: National Parts Depotwww.npdlink.comWith 4 warehouses nationwide, you'll get your parts fast!Email Doug: doug@turnkeypodcast.com"Keep it safe, keep it rollin', and keep it on the road. Until next time!" Doug SandlerRent your Classic Ford for commercials, film and special eventswww.ClassicFordRentals.comSign up today free of charge
Well, if you let Jon off the leash, you get X thing that isn't Star Wars, so I guess we shouldn't be surprised we're reading about Mulder and Scully now. And some archaeologist named Cassandra Rubicon who you simply must know is incredibly hot, it is vital. Learn more about your ad choices. Visit megaphone.fm/adchoices
In this episode of the Oncology Brothers podcast, we dived deep into the evolving landscape of HER2-positive breast cancer treatment following the significant advancements made in 2025. Joined by Dr. Virginia Kaklamani from UT Health San Antonio, we discussed the latest data from SABCS 2025 and pivotal trials such as DESTINY-Breast09, which have led to new treatment approvals and strategies. Listen us on: Spotify: https://open.spotify.com/show/31BXhY9FM4gPWG10WgE11o Follow us on social media: • X/Twitter: https://twitter.com/oncbrothers • Instagram: https://www.instagram.com/oncbrothers • Website: https://oncbrothers.com/ Key topics included: • The treatment algorithm for early-stage HER2-positive breast cancer, including the APT trial and the role of trastuzumab. • Insights into neoadjuvant and adjuvant therapies, including the implications of the neoCARHP trial regimen and the potential of T-DXd. • The impact of recent studies in metastatic HER2-positive disease, including the approval of T-DXd plus pertuzumab and the promising results from the PATINA trial. • A discussion on managing side effects and the importance of patient quality of life during treatment. Join us for an informative conversation that highlights the latest advancements in HER2-positive breast cancer care and how they can be applied in clinical practice. Don't forget to like, subscribe, and leave a review to help us reach more healthcare professionals who can benefit from these discussions! #HER2Positive, #BreastCancer, #SABCS25, #TDXd, #BreastCancerTreatment, #OncologyBrothers
The Patina regroups and brings out the big guns.Cast: - Marathon Messenger is played by Penn Van Batavia. She can be found on Twitter at @acquiredchaste and in drag as horror king JOHN on Instagram at @john.is.risen. Penn is an indie TTRPG designer whose most recent work includes SLICE *IT* OUT, a grisly carving RPG about cutting pieces of yourself out to fit in. Check out faer other work at pennharper.itch.io. - Cassidy Shard is played by Sydney Whittington. She is our wonderful editor. She's also a contributing editor and occasional guest player for the Orpheus Protocol, a cosmic horror espionage actual play podcast. Find her on Twitter at @sydney_whitt. - Emma Blackwood is played by Cameron Robertson. Find her on Twitter at @midnightmusic13 and on Instagram at @reading_and_dreaming. Cameron is also a player on Tabletop Squadron, a Star Wars Edge of the Empire actual play podcast. - Birdie Foundling is played by Kit Adames. Find her on Twitter at @venusvultures. Kit is also a voice actor and writer on Elevator Pitch Podcast, a queer genre-hopping anthology podcast that can be accessed on Spotify and YouTube. - Our GM and narrator is Nick Robertson. Find him on Twitter at @alias58. Nick is also the GM for Tabletop Squadron and can also be found as a player on the Orpheus Protocol.Music & Sound Credits: - This podcast features the musical talents of Dora Violet and Arne Parrott. You can find Dora at facebook.com/doraviolett. You can find Arne at atptunes.com. - old radio Channel search sound effect by Garuda1982. Link & License. - Memories in Love (ID 1144) by Lobo Loco. Link & License. - Carrot Sticks by Doctor Turtle. Link & License.Art Credits: - The official artwork for this podcast was created by Rashed AlAkroka, who can be found on Instagram and Artstation @rashedjrs.Find Us Online: - Our Website - Twitter - Join our Patreon - Join our Discord
Got a classic Ford in SoCal? Mustang. F-Series. Survivor. Patina. Show truck. I'm looking to put real classics on real sets — photo shoots, commercials, film, and premium productions. You keep your ride. I handle the clients, bookings, and logistics. Turn your classic Ford into a paid, on-camera icon.Visit ClassicFordRentals.com, scroll to the bottom of the page, and share your info with me— let's get your truck or Mustang working.Now, onto today's guest. What could be more fun than one Classic Mustang? TWO!! Here to share her Mustang story and how she got into a 1965 and a 1972 pony, welcome Jen Ketrow to Ford Mustang The Early Years Podcast.Connect with the show:@mustangpodcasthttps://www.instagram.com/mustangpodcast/An Expert's Guide to Maintaining Your Classic Mustangwww.TheMustangPodcast.com/repairSponsored by: National Parts Depotwww.npdlink.comWith 4 warehouses nationwide, you'll get your parts fast!Email Doug: doug@turnkeypodcast.com"Keep it safe, keep it rollin', and keep it on the road. Until next time!" Doug SandlerRent your Classic Ford for commercials, film and special eventswww.ClassicFordRentals.comSign up today free of charge
Hello dear listener, Welcome back! This week, I'm joined by my trusty sidekick, Matt Knight, and we're talking all about the new affordable Nitro Finished guitars from Patina Guitars! Hosted on Acast. See acast.com/privacy for more information.
The Patina battles mercenaries and unravels the heart of Sasnak Traveling.Cast: - Marathon Messenger is played by Penn Van Batavia. She can be found on Twitter at @acquiredchaste and in drag as horror king JOHN on Instagram at @john.is.risen. Penn is an indie TTRPG designer whose most recent work includes SLICE *IT* OUT, a grisly carving RPG about cutting pieces of yourself out to fit in. Check out faer other work at pennharper.itch.io. - Cassidy Shard is played by Sydney Whittington. She is our wonderful editor. She's also a contributing editor and occasional guest player for the Orpheus Protocol, a cosmic horror espionage actual play podcast. Find her on Twitter at @sydney_whitt. - Emma Blackwood is played by Cameron Robertson. Find her on Twitter at @midnightmusic13 and on Instagram at @reading_and_dreaming. Cameron is also a player on Tabletop Squadron, a Star Wars Edge of the Empire actual play podcast. - Birdie Foundling is played by Kit Adames. Find her on Twitter at @venusvultures. Kit is also a voice actor and writer on Elevator Pitch Podcast, a queer genre-hopping anthology podcast that can be accessed on Spotify and YouTube. - Our GM and narrator is Nick Robertson. Find him on Twitter at @alias58. Nick is also the GM for Tabletop Squadron and can also be found as a player on the Orpheus Protocol.Music & Sound Credits: - This podcast features the musical talents of Dora Violet and Arne Parrott. You can find Dora at facebook.com/doraviolett. You can find Arne at atptunes.com. - old radio Channel search sound effect by Garuda1982. Link & License. - gunshot.wav by mark646. Link & License. - " Bangs and Explosions » Explosion_001.mp3 " by cydon. Link & License. - Sundial_Bridge_03_cable_13.flac by DAAyer. Link & License. - The Leopard by Julia Kent. Link & License. - Long Story by Sergey Cheremisinov. Link & License.Art Credits: - The official artwork for this podcast was created by Rashed AlAkroka, who can be found on Instagram and Artstation @rashedjrs.Find Us Online: - Our Website - Twitter - Join our Patreon - Join our Discord
Reviewing the hot-off-the press publication of PATINA, palbociclib in HER-2 amplified breast cancer along with endocrine therapy and HER-2 targeted antibodies.
The Patina continues trying to save Sasnak Traveling while simultaneously dismantling the city's innermost security protocols.Cast: - Marathon Messenger is played by Penn Van Batavia. She can be found on Twitter at @acquiredchaste and in drag as horror king JOHN on Instagram at @john.is.risen. Penn is an indie TTRPG designer whose most recent work includes SLICE *IT* OUT, a grisly carving RPG about cutting pieces of yourself out to fit in. Check out faer other work at pennharper.itch.io. - Cassidy Shard is played by Sydney Whittington. She is our wonderful editor. She's also a contributing editor and occasional guest player for the Orpheus Protocol, a cosmic horror espionage actual play podcast. Find her on Twitter at @sydney_whitt. - Emma Blackwood is played by Cameron Robertson. Find her on Twitter at @midnightmusic13 and on Instagram at @reading_and_dreaming. Cameron is also a player on Tabletop Squadron, a Star Wars Edge of the Empire actual play podcast. - Birdie Foundling is played by Kit Adames. Find her on Twitter at @venusvultures. Kit is also a voice actor and writer on Elevator Pitch Podcast, a queer genre-hopping anthology podcast that can be accessed on Spotify and YouTube. - Our GM and narrator is Nick Robertson. Find him on Twitter at @alias58. Nick is also the GM for Tabletop Squadron and can also be found as a player on the Orpheus Protocol.Music & Sound Credits: - This podcast features the musical talents of Dora Violet and Arne Parrott. You can find Dora at facebook.com/doraviolett. You can find Arne at atptunes.com. - old radio Channel search sound effect by Garuda1982. Link & License. - gunshot.wav by mark646. Link & License. - Centerfire_Rifle_Gun_Shot_01.wav by MATRIXXX_. License. - Sword Shing 19 by Department64. Link & License. - White Atlantis by Sergey Cheremisinov. Link & License. - The Signals by Sergey Cheremisinov. Link & License.Art Credits: - The official artwork for this podcast was created by Rashed AlAkroka, who can be found on Instagram and Artstation @rashedjrs.Find Us Online: - Our Website - Twitter - Join our Patreon - Join our Discord
Episode 205 of the Down to Herf Podcast is live, and we kick things off with a full review of the Black Label Trading Co. Deliverance Nocturne. We break down the flavor profile, construction, and where this cigar stacks up among recent BLTC releases.From there, we shift gears into the gut-punch Buffalo Bills overtime loss to the Denver Broncos, unpacking the fallout, missed opportunities, and what it means moving forward.Patrol Gone Wild delivers this week with a ride-along that takes a completely unexpected turn, a furry arrest, and a woman who quite literally took the wrong way to work—with predictable results.Caleb's News rounds out the episode with fresh cigar release announcements from Patina and United, plus a look at a new special Knob Creek release that bourbon fans will want on their radar.Cigar: Black Label Trading Co Deliverance Nocturne 2025A huge thank you to our show sponsors Crowned Heads Cigars, and Small Batch Cigars! Make sure you're checking them out for all of your cigar needs!https://www.crownedheads.comhttps://www.smallbatchcigar.comUse Code "HERF" For 10% off your order (Some Exclusions Apply)Join The After Herf Show on Patreon Now!Patreon: https://www.patreon.com/DownToHerfPodcastVisit our Social Media Pages for News and More!Instagram: https://www.instagram.com/downtoherfpodcast/Facebook: https://www.facebook.com/downtoherfpodcast/Support the show
After reaching the core, the Patina rebandages wounds and begins their task of hacking into the city.Cast: - Marathon Messenger is played by Penn Van Batavia. She can be found on Twitter at @acquiredchaste and in drag as horror king JOHN on Instagram at @john.is.risen. Penn is an indie TTRPG designer whose most recent work includes SLICE *IT* OUT, a grisly carving RPG about cutting pieces of yourself out to fit in. Check out faer other work at pennharper.itch.io. - Cassidy Shard is played by Sydney Whittington. She is our wonderful editor. She's also a contributing editor and occasional guest player for the Orpheus Protocol, a cosmic horror espionage actual play podcast. Find her on Twitter at @sydney_whitt. - Emma Blackwood is played by Cameron Robertson. Find her on Twitter at @midnightmusic13 and on Instagram at @reading_and_dreaming. Cameron is also a player on Tabletop Squadron, a Star Wars Edge of the Empire actual play podcast. - Birdie Foundling is played by Kit Adames. Find her on Twitter at @venusvultures. Kit is also a voice actor and writer on Elevator Pitch Podcast, a queer genre-hopping anthology podcast that can be accessed on Spotify and YouTube. - Our GM and narrator is Nick Robertson. Find him on Twitter at @alias58. Nick is also the GM for Tabletop Squadron and can also be found as a player on the Orpheus Protocol.Music & Sound Credits: - This podcast features the musical talents of Dora Violet and Arne Parrott. You can find Dora at facebook.com/doraviolett. You can find Arne at atptunes.com. - old radio Channel search sound effect by Garuda1982. Link & License. - Labyrinth by Sergey Cheremisinov. Link & License. - What Is It I Know by The Oracle Of St. Vincent. Link & License.Art Credits: - The official artwork for this podcast was created by Rashed AlAkroka, who can be found on Instagram and Artstation @rashedjrs.Find Us Online: - Our Website - Twitter - Join our Patreon - Join our Discord
Dr. Monty Pal and Dr. Hope Rugo discuss advances in antibody-drug conjugates for various breast cancer types as well as treatment strategies in the new era of oral SERDs for HR-positive breast cancer. TRANSCRIPT Dr. Monty Pal: Hello, and welcome to the ASCO Daily News Podcast. I'm your host, Dr. Monty Pal. I'm a medical oncologist and vice chair of academic affairs here at the City of Hope Comprehensive Cancer Center, Los Angeles. Today, I'm thrilled to be joined by Dr. Hope Rugo, an internationally renowned breast medical oncologist and my colleague here at City of Hope, where she leads the Women's Cancers Program and serves as division chief of breast medical oncology. Dr. Rugo is going to share with us exciting advances in antibody-drug conjugates (ADCs) that are expanding treatment options in various breast cancer types. She'll also address some of the complex questions arising in the new era of oral SERDs (selective estrogen receptor degraders) that are revolutionizing treatment in the hormone receptor-positive breast cancer space. Our full disclosures are available in the transcript of this episode. Dr. Rugo, welcome, and thanks so much for being on the podcast today. Dr. Hope Rugo: Thank you. Pleasure to be here. Dr. Monty Pal: So, I'm going to switch to first names if you don't mind. The first topic is actually a really exciting one, Hope, and this is antibody-drug conjugates. I don't know if I've ever shared this with you, but I actually started my training at UCLA, I was a med student and resident there, and it was in Dennis Slamon's lab. I worked very closely with Mark Pegram and a handful of others. This is right around the time I think a lot of HER2-directed therapies were really evolving initially in the clinics. Now we've got antibody-drug conjugates. Our audience is well-familiar with the mechanism there but tell us about how ADCs have really started to reshape therapy for HER2-positive breast cancer. Dr. Hope Rugo: Yeah, I mean, this is a really great place to start. I mean, we have had such major advances in breast cancer just this year, I think really changing the paradigm of treating patients. But HER2-positive disease, we've been used to having sequenced success of new agents. And I think the two biggest areas where we've made advances in HER2-positive disease, which were remarkably advanced this year in 2025, have been in antibody-drug conjugates with trastuzumab deruxtecan and with new oral tyrosine kinase inhibitors (TKIs) that have less of a target on EGFR and more on HER2, so they have an overall more tolerable toxicity profile and therefore a potentially better efficacy in the clinic. At least that's what we're seeing with these new strategies that we couldn't really pursue in the past because of toxicities of the oral TKIs. So, although our topic is ADCs, I'm going to include the TKI because it's so important in our thinking about treating HER2-positive disease. In the metastatic setting, we've seen these remarkable improvements in progression-free and overall survival in the second-line setting with T-DXd, or trastuzumab deruxtecan, compared to T-DM1. And then sequencing ADCs with giving T-DXd after T-DM1 was better than an oral tyrosine kinase or a trastuzumab combination with standard chemotherapy. That was DESTINY-Breast03 and DESTINY-Breast02. So, then we've had other trials since then, and T-DXd has moved into the early-stage setting, which I'll talk about in just a moment. But the next big trial for T-DXd in HER2-positive disease was moving it to the first-line setting to supplant what has become an established treatment for now quite a long time: the so-called CLEOPATRA regimen, which used the combined antibodies trastuzumab, pertuzumab with a taxane as first-line therapy. And then we've proceeded on with maintenance with ongoing HP for patients with responding or stable disease. And we'd seen long-term data showing, you know, at 8 years there was a group of patients whose cancers had never progressed and continued improved overall survival. So, T-DXd was studied in DESTINY-Breast09, either alone or in combination with pertuzumab compared to THP. The patient population had received a little bit more prior treatment, but interestingly, not a lot compared to CLEOPATRA. And they designed the trial to be T-DXd continued until progression with or without pertuzumab versus THP, which would go for six cycles and then stop around six cycles, and then stop and continue HP. Patients who had hormone receptor-positive disease could use hormone therapy, and this is one of the issues with this dataset because, surprisingly in this dataset and one other I'll mention, very few patients took hormone therapy. And even in the maintenance trial, the HER2CLIMB-05, less than 50% took hormone therapy as maintenance. This is kind of shocking to me and highlights an area of really important education, that outcome is improved when you add endocrine therapy for hormone receptor-positive HER2-positive metastatic disease in the maintenance phase, and it's a really important part of treatment. But suffice it to say, you know, you're kind of studying continued chemo versus stopping chemo in maintenance. And T-DXd, as we all expected, in combination with pertuzumab was superior to THP in terms of progression-free survival, really remarkably improved. And you could stop the chemo with toxicity, but most people continued it with T-DXd. Again, not a lot of people got hormone therapy, which is an issue, and you stop the chemo in the control arm. So, this has brought up a lot of interest in trying to use T-DXd as an induction and then go to maintenance, much as we do with the CLEOPATRA regimen with hormone therapy. But it brings up another issue. So first, T-DXd is superior; it's a great treatment. Not everybody needs to have it because we don't know whether it's better to give T-DXd first or second with progression - that we need a little bit longer follow-up. But just earlier this week, interestingly, the third week of December, the U.S. FDA approved T-DXd in the DESTINY-Breast09 approach with pertuzumab. So as I mentioned earlier, there was a T-DXd-alone arm; that arm has not yet reported. So very interesting, we don't know if you need pertuzumab or not. So what about the maintenance? That's the other area where we've made a huge advance here. So, we all want to stop chemo and we want to stop T-DXd. You don't want somebody being nauseated for two years while they're on treatment, and also there's a small number of patients with mostly de novo metastatic HER2-positive disease who are cured of their disease. We'd like to expand that, and I think these new drugs give us the opportunity to improve the number of patients who might be cured from metastatic disease. So the first maintenance study we saw was adding palbociclib, the CDK4/6 inhibitor, to endocrine therapy and HP, essentially. There, we had a remarkable improvement in progression-free survival difference of 15.2 months: 29 to 44 months, really huge. At San Antonio this year, we saw data with this oral tyrosine kinase inhibitor tucatinib, already showed it was great in a triplet, but as maintenance in combination with HP, it showed also a remarkable improvement in progression-free survival. But the numbers were all shifted down. So in PATINA, the control arm was in the 24-month range; here it was the tucatinib-HP arm that was in the 25 months and 16 months for control. So there was a differential benefit in ER-negative and ER-positive disease. So I think we're all thinking that our ideal approach moving forward would be to give T-DXd to most patients, we see how they do, and treat to best response. And then, stop the T-DXd, start HP, trastuzumab, pertuzumab for ER-negative, with tucatinib for ER-positive with palbociclib. We also have early data that suggests that both approaches may reduce the development of brain metastases, an issue in HER2-positive disease, and delay time to progression of brain metastases as seen in HER2CLIMB-05 in very early data - small numbers, but still quite intriguing that you might delay progression of brain metastases with tucatinib that clearly has efficacy in the brain. So, I think that this is a hugely exciting advance for our patients, and these approaches are quickly moving into the early stage setting. T-DXd compared to standard chemo, essentially followed by THP, so a sequenced approach resulted in more pathologic complete responses than a standard THP-AC-type neoadjuvant therapy. T-DXd alone for eight cycles wasn't better, and that's interesting. We still need the sequenced non-cross-resistant chemo. But I think even more importantly, the data from DESTINY-Breast05 looking at T-DXd versus T-DM1 in patients with residual disease after neoadjuvant HER2-targeted therapy showed a remarkable improvement in invasive disease-free survival with T-DXd versus T-DM1, and quite early. It was a high-risk population, higher risk than the T-DM1 trial with KATHERINE, but earlier readout with a remarkable improvement in outcome. We expect to be FDA approved sometime in the first half of 2026. So then we'll get patients who've already had T-DXd who get metastatic disease. But my hope is that with T-DXd, maybe with tucatinib in the right group of patients or even sequenced in very high-risk disease, that we could cure many more patients with early-stage HER2-positive breast cancer and cure a subset, a greater subset of patients with de novo metastatic disease. Dr. Monty Pal: That's brilliant. And you tackled so many questions that I was going to follow up with there: brain metastases, etc. That was sort of looming in my mind. I mean, general thoughts on an ADC versus a TKI in the context of brain mets? Dr. Hope Rugo: Yeah, it's an interesting question because T-DXd has shown quite good efficacy in this setting. And tucatinib, of course, had a trial where they took patients with new brain mets, so a larger population than we've seen yet for the T-DXd trials, and saw that not only did they delay progression of brain metastases and result in shrinkage of existing untreated brain mets, but that patients who develop a new brain met, they could stay on the same assigned treatment. They got stereotactic radiation, and then the patients who were on tucatinib with trastuzumab and capecitabine had a further delay in progression of brain mets compared to those on the placebo arm, even after treatment of a new one that developed on treatment. So, I think it's hard. I think most of us for a lot of brain mets might start with the tucatinib approach, but T-DXd is also a very important treatment. You know, you're kind of trading off a diarrhea, some liver enzyme elevations with tucatinib versus nausea, which you really have to work on managing because it can be long-delayed nausea, and this risk of ILD, interstitial lung disease, that's about 12%, with most but not all trials showing a mortality rate from interstitial lung disease of just under 1 percent. In the early-stage setting, it was really interesting to see that with T-DXd getting four cycles in the neoadjuvant setting, a lot less ILD noted than the patients who got up to 14 cycles, as I think they got a median of 10 cycles in the post-surgical setting, there was a little bit more ILD. But I think we're going to be better and better at finding this earlier and preventing mortality by just stopping drug and treating earlier with steroids. Dr. Monty Pal: And this ILD issue, it always seems to resurface. There are drugs that I use in my kidney cancer clinic, everolimus, common to perhaps the breast cancer clinic as well, pembrolizumab, where I think the pattern of pneumonitis is quite different, right? What is your strategy for recognizing pneumonitis early in this context? Dr. Hope Rugo: Well, it is, and you know, having done the very early studies in everolimus where we gave it in the neoadjuvant setting and we're like, "Hmm, the patient came in with a cough. What's going on?" You know, we didn't know. And you have mouth sores, you know, we were learning about the drug as we were giving it. What we don't do with everolimus and CDK4/6 inhibitors, for example, is grade 1 changes like radiation pneumonitis, we don't stop, we don't treat it. We only treat for symptoms. But because of the mortality associated with T-DXd, albeit small, we stop drug for grade 1 imaging-only asymptomatic pneumonitis, and some of us treat with a half dose of steroids just to try and hasten recovery. We've actually now published or presented a couple of datasets from trials, a pooled analysis and a real-world analysis, that have looked at patients who were retreated after grade 1 pneumonitis or ILD and tolerated drug very well and none of them died of interstitial lung disease, which was really great to see because you can retreat safely and some of these patients stayed on for almost a year benefiting from treatment. So, there's a differential toxicity profile with these drugs and there are risk factors which clearly have identified those at higher risk: prior ILD, for example. A French group said smoking; other people haven't found that, maybe because they smoked more in France, I don't know. And being of Japanese descent is quite interesting. The studies just captured that you were treated in Japan, but I think it's probably being of Japanese descent with many drugs that increases your risk of ILD. And, you know, older patients, people who have hypoxia, those are the patients. So, how do we do this? With everolimus, we don't have specific monitoring. But for T-DXd we do; we do every nine weeks to start with and then every 12 weeks CT scans because most of the events occur relatively early. Somebody who's older and at higher risk now get the first CT at six weeks. Dr. Monty Pal: This is super helpful. And I have to tell you, a lot of these drugs are permeating the bladder cancer space which, you know, is ultimately going to be a component of my practice, so thank you for all this. We could probably stay on this topic of HER2-positive disease forever. I'm super interested in that space still. But let me shift gears a little bit and talk about triple-negative breast cancer and this evolving space of HR-positive, HER2-low breast cancer. I mean, tell us about ADCs in that very sort of other broad area. Dr. Hope Rugo: So triple-negative disease is the absolute hardest subset of disease that we have to treat because if you don't have a great response in the early stage setting, the median survival is very short, you know, under two years for the majority of TNBCs, with the exception of the small percentage of low proliferative disease subsets. The co-question is what do we do for these patients and how do we improve outcome? And sacituzumab govitecan has been one strategy in the later line setting that was shown to improve progression-free and overall survival, the Trop-2 ADC. We had recently three trials presented with the two ADCs, sacituzumab govitecan and the other Trop-2 ADC that's approved for HR-positive disease, datopotamab deruxtecan. And they were studied in the first-line setting. Two trials with SG, sacituzumab govitecan, those trials, one was PD-L1 positive, ASCENT-04. That showed that SG with a checkpoint inhibitor was superior, so pembrolizumab was superior to the standard KEYNOTE-355 type of treatment with either a taxane or gemcitabine and carboplatin with pembrolizumab for patients who have a combined positive score for PD-L1, 10 or greater. So, these are patients who are eligible for a checkpoint inhibitor, and SG resulted in an improved progression-free survival. The interesting thing about that dataset is that few patients had received adjuvant or neoadjuvant checkpoint inhibitor, which is fascinating because we give it to everybody now. But access is an issue and timing of the study enrollment was an issue. The other thing which I think we've all really applauded Gilead for is that there was automatic crossover. So, you could get from the company, to try and overcome some of the enormous disparities worldwide in access to these life-saving drugs, you could get SG through the company for free once you had blinded independent central review confirmation of disease progression. Now, a lot of the people who got the SG got it through their insurance, they didn't bill the company, but 80 percent of patients in the control arm received SG in the second-line setting. So that impacts your ability to look at overall survival, but it's an incredibly important component of these trials. So then at ESMO, we saw the data from SG and Dato-DXd in the first-line metastatic setting for patients who either had PD-L1-negative disease or weren't eligible for an immunotherapy. For the Dato study, TROPION-Breast02, that was 10 percent of the patients who had PD-L1-positive disease but didn't get a checkpoint inhibitor, and for the ASCENT-03 trial population it was only 1 percent. Importantly, the trials allowed patients who relapsed within a year of receiving their treatment with curative intent, and the Dato study, TB-02, allowed patients who relapsed while on treatment or within the first six months, and that was 15 percent of the 20 percent of early relapsers. The ASCENT trial, ASCENT-03, had 20 percent who relapsed between 6 and 12 months. The drugs were better than standard of care chemotherapy, the ADCs in both trials, which is very nice. Different toxicity profiles, different dosing intervals, but better than standard of care chemotherapy in the disease that's hardest for us to treat. And importantly, when you looked at the subset of early relapsers, those patients also did better with the ADC versus chemotherapy, which is incredibly important. And we were really interested in that 15 percent of patients who had early relapse. I actually think that six months thing was totally contrived, invented, you know, categorization and doesn't make any sense, and we should drop it. But the early relapsers were 15 percent of TB-02 and Dato was superior to standard of care chemo. We like survival, but the ASCENT trial again allowed the crossover to an approved ADC that improved survival and 80 percent of patients crossed over. In the Dato trial, they did not allow crossover, they didn't provide Dato, which isn't approved for TNBC but is for HR-positive disease, and they didn't allow, of course, pay for SG. So very few patients actually crossed over in their post-treatment data and in that study, they were able to show a survival benefit. So actually, I think in the U.S. where we can use approved drugs already before there's a fixed FDA approval, that people are already switching to use SG or Dato in the first-line setting for metastatic TNBC that's both PD-L1 positive for SG and PD-L1 negative for both drugs. And I think understanding the toxicity profiles of the two drugs is really important as well as the dosing interval to try and figure out which drug to use. Dr. Monty Pal: Brilliant. Brilliant. Well, I'm going to shift gears a little bit. ADCs are a topic, again, just like HER2-positive disease we could stay on forever. Dr. Hope Rugo: Huge. Yes. Dr. Monty Pal: But we're going to shift gears to another massive topic, which is oral SERDs. In broad strokes, right, this utilization of CDK4/6 inhibitors in the context of HR-positive breast cancer is obviously, you know, a paradigm that's been well established at this point. Where do we sequence in oral SERDs? Where do they fit into this paradigm? Dr. Hope Rugo: Ha! This is a rapidly changing area; we keep changing what we're saying every other minute. And I think that there are three areas of great interest. So one is patients who develop ESR1 mutations that allow constitutive signaling through the estrogen receptor, even when there's not estrogen around, and that is a really important mutation that is subclonal; it develops under the pressure of treatment in about 40 percent of patients. And it doesn't happen when you first walk in the door. And what we've seen is that oral SERDs as single agents are better than standard single-agent endocrine therapy in that setting. The problem that we've had with that approach is that we're now really interested in giving targeted agents with our endocrine therapies, not just in the first-line setting where CDK4/6 inhibitors are our standard of care with survival benefit for ribociclib and, you know, survival benefit in subsets with other CDK4/6 inhibitors, and abemaciclib with a numeric improvement. So we give it first line. The question is, what do you do in the second-line setting? Because of the recent data, we now believe that oral SERDs should be really given with a targeted agent. And some datasets which were recently presented, which I think have helped us with that, have been EMBER-3 and then the most recently evERA BC, or evERA Breast Cancer, that looked at the oral SERD giredestrant with everolimus compared to standard of care endocrine therapy with everolimus, where 100 percent of patients received prior CDK4/6 inhibitor and showed a marked improvement in progression-free survival, including in the subsets of patients with a short response, 6-12 months of prior response to CDK4/6 inhibitor and in those who had a PIK3CA pathway mutation. The thing is that the benefit looks like it's much bigger in the ESR1 mutant population, although response was better, PFS wasn't better in the wild type. So, we're still trying to figure that out. We also saw EMBER-3 with imlunestrant and abemaciclib as a second line. Not everybody had had a prior CDK4/6 inhibitor; they compared it to imlunestrant alone, but still the data was quite striking and seemed to cross the need for ESR1 mutations. And then lastly, we saw data from the single arms of the ELEVATE trial looking at elacestrant with everolimus and abemaciclib and showed these really marked progression-free survival data, even though single-arm, that crossed the mutation status. At least for the everolimus combination, abemaciclib analysis is still to come in the mutated subgroups. But really remarkable PFS, much longer. Single-agent fulvestrant after CDK4/6 inhibitor AI has a PFS in like the three-month range and in some studies, maybe close to five months. These are all at 10-plus months and really looking very good. And so those questions are, is it ESR1 mutation alone? Is it all comers? We'd like all comers, right? We believe in the combination approach and we're learning more about combinations with drugs like capivasertib and other drugs as we move forward. Everybody now wants to combine their targeted agent with an oral SERD because they're clearly here to stay with quite remarkable data. The other issue, so the second issue in the metastatic setting is, does it make a difference if we change to an oral SERD before radiographic imaging evidence of progression? And that was the question asked in the SERENA-6 trial where patients had serial monitoring for the presence of ESR1 mutations in ctDNA. And those who had them without progression on imaging could be randomized to switch to camizestrant with the same CDK4/6 inhibitor or stay on their same AI CDK4/6 inhibitor. And they showed a difference in progression-free survival that markedly favored camizestrant. But interestingly, the people who were on the standard control arm had an ESR1 mutation, we think AIs don't work, they stayed on for nine more months. The patients who were on the camizestrant stayed on for more than 16 months. And they presented some additional subset data which showed the same thing: follow-up PFS data, PFS2, all beneficial in SERENA-6 at the San Antonio [Breast Cancer Symposium]. So, we're still a little bit unclear about that. They did quality of life, and pain was markedly improved. They had a marked delayed time to progression of pain in the camizestrant arm. So this is all a work in progress, trying to understand who should we switch without progression to an oral SERD based on this development of this mutation that correlates with resistance. And, you know, it's interesting because the median time to having a mutation was 18 months and the median time to switch was almost 24 months. And then there were like more than 3,000 patients who hadn't gotten a mutation, hadn't switched, and were still okay. So screening everybody is the big question, and when you would start and who you would change on and how this affects outcome. Patients didn't have access to camizestrant in the control arm, something we can't fix but we have experimental drugs. We're actually planning a trial, I hope in collaboration with the French group Unicancer, and looking at this exact question. You know, if you switch and you change the CDK4/6 inhibitor and then you also allow crossover, what will we see? Dr. Monty Pal: We're coming right to the tail end of our time here, and I could probably go on for another couple of hours with you here. But if you could just give us maybe one or two big highlights from San Antonio, any thoughts to leave our audience with here based on this recent meeting? Dr. Hope Rugo: Yeah, I mean, I talked about a lot of those new data already from San Antonio, and the one that I'd really like to mention which I think was, you know, there were a lot of great presentations including personalized screening presented from the WISDOM trial by my colleague Laura Esserman, fascinating and really a big advance. But lidERA was the big highlight, I think, outside of the HER2CLIMB-05 which I talked about earlier in HER2-positive disease. And this study looked at giredestrant, the oral SERD versus standard of care endocrine therapy as treatment for medium and high-risk early-stage breast cancer. And what they showed, which I think was really remarkable with just about a three-year median follow-up, was an improvement in invasive disease-free survival with a hazard ratio of 0.7. I mean, really quite remarkable and so early. It looked as though this was all driven by the high-risk group, which makes sense, not the medium risk, it's too early. And also that there was a bigger benefit in patients who were on tamoxifen compared to giredestrant versus AI, but for both groups, the confidence intervals didn't cross 1. There's even a trend towards overall survival, even though it's way too early. I think that, you know, really well-tolerated oral drug that could improve outcome in early-stage disease, this is the first advance we've seen in over two decades in the treatment of early-stage hormone receptor-positive disease with just endocrine therapy. I think we think that we don't want to give up CDK4/6 inhibitors because we saw a survival benefit with abemaciclib and a trend with giving ribociclib in the NATALEE trial. So we're thinking that maybe one approach would be to give CDK4/6 inhibitors and then switch to an oral SERD or to have enough data to be able to give oral SERDs with these CDK4/6 inhibitors for early-stage disease. And that's all in the works, you know, lots of studies going on. We're going to see a lot of data with both switching 8,000 patients with an imlunestrant switching trial, an elacestrant trial going on, and safety data with giredestrant with abemaciclib and soon to come ribociclib. So, this is going to change everything for the treatment of early-stage breast cancer, and I hope cure more patients of the most common subset of the most common cancer diagnosed in women worldwide. Dr. Monty Pal: Super exciting. It's just remarkable to hear how this has evolved since 25 years ago, which is really the last time I sort of dabbled in breast cancer. Thank you so much, Hope, for joining us today. These were fantastic insights. Appreciate you being on the ASCO Daily News Podcast and really want to thank you personally for your remarkable contribution to the field of breast cancer. Dr. Hope Rugo: Thank you very much, and thanks for talking with me today. Dr. Monty Pal: You got it. And thanks a lot to our listeners today as well. You'll find links to all the studies we discussed today in the transcript of this episode. Finally, if you value the insights that you hear today on the ASCO Daily News Podcast, please rate, review, and subscribe wherever you get your podcasts. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinion of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Follow today's speakers: Dr. Monty Pal @montypal Dr. Hope Rugo @hoperugo Follow ASCO on social media: ASCO on X ASCO on Bluesky ASCO on Facebook ASCO on LinkedIn Disclosures: Dr. Monty Pal: Speakers' Bureau: MJH Life Sciences, IntrisiQ, Peerview Research Funding (Inst.): Exelixis, Merck, Osel, Genentech, Crispr Therapeutics, Adicet Bio, ArsenalBio, Xencor, Miyarsian Pharmaceutical Travel, Accommodations, Expenses: Crispr Therapeutics, Ipsen, Exelixis Dr. Hope Rugo: Honoraria: Mylan/Viatris, Chugai Pharma Consulting/Advisory Role: Napo Pharmaceuticals, Sanofi, Bristol Myer Research Funding (Inst.): OBI Pharma, Pfizer, Novartis, Lilly, Merck, Daiichi Sankyo, AstraZeneca, Gilead Sciences, Hoffman La-Roche AG/Genentech, In., Stemline Therapeutics, Ambryx
Join us as we dive into the latest advancements in HER2-positive breast cancer from SABCS 2025. In this episode, we discussed key studies including DESTINY Breast-11 and DESTINY Breast-05, highlighting their implications for neoadjuvant and adjuvant treatments. We also explored the HER2CLIMB-05 trial and the recent approval of TDXD with pertuzumab in frontline settings for metastatic HER2-positive disease. Special guest Dr. Harold Burstein from Dana-Farber Cancer Institute shared his insights on the evolving landscape of HER2-positive breast cancer treatment, including the importance of patient selection and the management of side effects like interstitial lung disease (ILD). Tune in for a comprehensive recap of the latest data, treatment algorithms, and how these advancements are changing the lives of patients with HER2-positive breast cancer. Don't forget to like, subscribe, and check out our other episodes for more updates on treatment options and conference highlights! Topics Covered: • DESTINY Breast-11 and its impact on neoadjuvant therapy • Insights from DESTINY Breast-05 on adjuvant treatment for high-risk residual disease • HER2CLIMB-05 trial findings and implications for metastatic disease • The role of T-DXd with pertuzumab in frontline settings • The PATINA trial and its significance for triple-positive metastatic breast cancer Follow us on social media: • X/Twitter: https://twitter.com/oncbrothers • Instagram: https://www.instagram.com/oncbrothers • Website: https://oncbrothers.com/ Don't forget to like, subscribe, and check out our other episodes for more insights on treatment algorithms, recent approvals, and conference highlights! #SABCS2025 #HER2positive #DestinyTrials #OncologyBrothers #BreastCancer
The Patina reluctantly returns to the Guts to reach the city core.Cast: - Marathon Messenger is played by Penn Van Batavia. She can be found on Twitter at @acquiredchaste and in drag as horror king JOHN on Instagram at @john.is.risen. Penn is an indie TTRPG designer whose most recent work includes SLICE *IT* OUT, a grisly carving RPG about cutting pieces of yourself out to fit in. Check out faer other work at pennharper.itch.io. - Cassidy Shard is played by Sydney Whittington. She is our wonderful editor. She's also a contributing editor and occasional guest player for the Orpheus Protocol, a cosmic horror espionage actual play podcast. Find her on Twitter at @sydney_whitt. - Emma Blackwood is played by Cameron Robertson. Find her on Twitter at @midnightmusic13 and on Instagram at @reading_and_dreaming. Cameron is also a player on Tabletop Squadron, a Star Wars Edge of the Empire actual play podcast. - Birdie Foundling is played by Kit Adames. Find her on Twitter at @venusvultures. Kit is also a voice actor and writer on Elevator Pitch Podcast, a queer genre-hopping anthology podcast that can be accessed on Spotify and YouTube. - Our GM and narrator is Nick Robertson. Find him on Twitter at @alias58. Nick is also the GM for Tabletop Squadron and can also be found as a player on the Orpheus Protocol.Music & Sound Credits: - This podcast features the musical talents of Dora Violet and Arne Parrott. You can find Dora at facebook.com/doraviolett. You can find Arne at atptunes.com. - old radio Channel search sound effect by Garuda1982. Link & License. - Breezy city amb.wav by patchen. Link & License. - Ricochet metal 3.wav by CGEffex. Link & License. - Comets and Sparks by Sergey Chersmisinov. Link & License. - Endearing Curl by Blue Dot Sessions. Link & License.Art Credits: - The official artwork for this podcast was created by Rashed AlAkroka, who can be found on Instagram and Artstation @rashedjrs.Find Us Online: - Our Website - Twitter - Join our Patreon - Join our Discord
We're joined by Mo Maali of Patina Cigars for a wide-ranging interview that starts with cigars and quickly goes off the rails—in the best way possible. We dive into Patina's recently released Red Pill cigar, breaking down the blend, the concept behind the project, and the messaging that sparked it all. What begins as a cigar review turns into a full rabbit-hole conversation touching on culture, perspective, and the need for change.Patrol Gone Wild delivers chaos as usual, featuring a former UFC fighter tied to a massive drug bust, a wild and unfortunate headline involving actor Rob Reiner, and yet another reminder that criminals still don't understand you cannot, in fact, outrun a helicopter.Caleb's News rounds things out with new release announcements from Viaje and Principle Cigars, while the whiskey segment looks at Garrison Brothers pushing the limits with the drop of a straight hazmat bottle.Cigar: Patina Red PillA huge thank you to our show sponsors Crowned Heads Cigars, Dunbarton Tobacco and Trust, and Small Batch Cigars! Make sure you're checking them out for all of your cigar needs!https://www.crownedheads.comhttps://www.dunbartoncigars.comhttps://www.smallbatchcigar.comUse Code "HERF" For 10% off your order (Some Exclusions Apply)Join The After Herf Show on Patreon Now!Patreon: https://www.patreon.com/DownToHerfPodcastVisit our Social Media Pages for News and More!Instagram: https://www.instagram.com/downtoherfpodcast/Facebook: https://www.facebook.com/downtoherfpodcast/Support the show
The Patina has a tense negotiation and the city fights back.Cast: - Marathon Messenger is played by Penn Van Batavia. She can be found on Twitter at @acquiredchaste and in drag as horror king JOHN on Instagram at @john.is.risen. Penn is an indie TTRPG designer whose most recent work includes SLICE *IT* OUT, a grisly carving RPG about cutting pieces of yourself out to fit in. Check out faer other work at pennharper.itch.io. - Cassidy Shard is played by Sydney Whittington. She is our wonderful editor. She's also a contributing editor and occasional guest player for the Orpheus Protocol, a cosmic horror espionage actual play podcast. Find her on Twitter at @sydney_whitt. - Emma Blackwood is played by Cameron Robertson. Find her on Twitter at @midnightmusic13 and on Instagram at @reading_and_dreaming. Cameron is also a player on Tabletop Squadron, a Star Wars Edge of the Empire actual play podcast. - Birdie Foundling is played by Kit Adames. Find her on Twitter at @venusvultures. Kit is also a voice actor and writer on Elevator Pitch Podcast, a queer genre-hopping anthology podcast that can be accessed on Spotify and YouTube. - Our GM and narrator is Nick Robertson. Find him on Twitter at @alias58. Nick is also the GM for Tabletop Squadron and can also be found as a player on the Orpheus Protocol.Music & Sound Credits: - This podcast features the musical talents of Dora Violet and Arne Parrott. You can find Dora at facebook.com/doraviolett. You can find Arne at atptunes.com. - old radio Channel search sound effect by Garuda1982. Link & License. - "Sekalaiset Miscellaneous » Sähköisiä räsähdyksiä / Electrical, short crackling, cracking, hissing sounds, like short-circuit, electric fault or electric shock, a close sound" by YleArkisto. Link & License. - "Ricochet" by ValhallaProject. Link & License. - Big Water by Sergey Cheremisinov. Link & License. - Lac des Arcs by Julia Kent. Link & License.Art Credits: - The official artwork for this podcast was created by Rashed AlAkroka, who can be found on Instagram and Artstation @rashedjrs.Find Us Online: - Our Website - Twitter - Join our Patreon - Join our Discord
Video zur Episode Text-/Audio-/Videokommentar einreichen HS-Hörer:innen im Slack treffen Aus der Preshow Guten Abend schreibt der youtube, aus der Badewanne podcasten, Nix HS Workshops Neue Workshops geöffnet: Fotoprojekte & Großformat HS Workshop-Newsletter Testimonials von Workshopteilnehmern gesucht Alte Newsletter funktionieren nicht mehr, bitte neu anmelden Neue Newsletter Statt Werbung DANKE an alle Spender #hshi / #hsnachtrag … „#921 – Podcast mit Patina“ weiterlesen
The Patina runs into more trouble as they try to reach the city core.Cast: - Marathon Messenger is played by Penn Van Batavia. She can be found on Twitter at @acquiredchaste and in drag as horror king JOHN on Instagram at @john.is.risen. Penn is an indie TTRPG designer whose most recent work includes SLICE *IT* OUT, a grisly carving RPG about cutting pieces of yourself out to fit in. Check out faer other work at pennharper.itch.io. - Cassidy Shard is played by Sydney Whittington. She is our wonderful editor. She's also a contributing editor and occasional guest player for the Orpheus Protocol, a cosmic horror espionage actual play podcast. Find her on Twitter at @sydney_whitt. - Emma Blackwood is played by Cameron Robertson. Find her on Twitter at @midnightmusic13 and on Instagram at @reading_and_dreaming. Cameron is also a player on Tabletop Squadron, a Star Wars Edge of the Empire actual play podcast. - Birdie Foundling is played by Kit Adames. Find her on Twitter at @venusvultures. Kit is also a voice actor and writer on Elevator Pitch Podcast, a queer genre-hopping anthology podcast that can be accessed on Spotify and YouTube. - Our GM and narrator is Nick Robertson. Find him on Twitter at @alias58. Nick is also the GM for Tabletop Squadron and can also be found as a player on the Orpheus Protocol.Music & Sound Credits: - This podcast features the musical talents of Dora Violet and Arne Parrott. You can find Dora at facebook.com/doraviolett. You can find Arne at atptunes.com. - old radio Channel search sound effect by Garuda1982. Link & License. - Metal_heavy_punch_with_crunch_and_glass_debris_sounds_08242024 by Artninja. Link & License. - Whistle, Finger, Long, A.wav by InspectorJ. Link & License. - explosive_punchy_rock_impacts_fate_stay_night_HF_inspired_11162025 by Artninja. Link & License. - gunshot.wav by mark646. Link & License. - Running Eiskrokodil (ID 01) - Remastered by Lobo Loco. Link & License. - Recognize Greatness by The Oracle Of St. Vincent. Link & License.Art Credits: - The official artwork for this podcast was created by Rashed AlAkroka, who can be found on Instagram and Artstation @rashedjrs.Find Us Online: - Our Website - Twitter - Join our Patreon - Join our Discord
The Patina reunites and figures out their next steps during the Battle of Sasnak Traveling.Cast: - Marathon Messenger is played by Penn Van Batavia. She can be found on Twitter at @acquiredchaste and in drag as horror king JOHN on Instagram at @john.is.risen. Penn is an indie TTRPG designer whose most recent work includes SLICE *IT* OUT, a grisly carving RPG about cutting pieces of yourself out to fit in. Check out faer other work at pennharper.itch.io. - Cassidy Shard is played by Sydney Whittington. She is our wonderful editor. She's also a contributing editor and occasional guest player for the Orpheus Protocol, a cosmic horror espionage actual play podcast. Find her on Twitter at @sydney_whitt. - Emma Blackwood is played by Cameron Robertson. Find her on Twitter at @midnightmusic13 and on Instagram at @reading_and_dreaming. Cameron is also a player on Tabletop Squadron, a Star Wars Edge of the Empire actual play podcast. - Birdie Foundling is played by Kit Adames. Find her on Twitter at @venusvultures. Kit is also a voice actor and writer on Elevator Pitch Podcast, a queer genre-hopping anthology podcast that can be accessed on Spotify and YouTube. - Our GM and narrator is Nick Robertson. Find him on Twitter at @alias58. Nick is also the GM for Tabletop Squadron and can also be found as a player on the Orpheus Protocol.Music & Sound Credits: - This podcast features the musical talents of Dora Violet and Arne Parrott. You can find Dora at facebook.com/doraviolett. You can find Arne at atptunes.com. - old radio Channel search sound effect by Garuda1982. Link & License. - 12120 collapsing building.wav by Robinhood76. Link & License. - Tramontana by Julia Kent. Link & License. - Glueworm Evening Blues (ID 994) by Lobo Loco. Link & License.Art Credits: - The official artwork for this podcast was created by Rashed AlAkroka, who can be found on Instagram and Artstation @rashedjrs.Find Us Online: - Our Website - Twitter - Join our Patreon - Join our Discord
The Patina fight their way back to each other and do some heroics along the way.Cast: - Marathon Messenger is played by Penn Van Batavia. She can be found on Twitter at @acquiredchaste and in drag as horror king JOHN on Instagram at @john.is.risen. Penn is an indie TTRPG designer whose most recent work includes SLICE *IT* OUT, a grisly carving RPG about cutting pieces of yourself out to fit in. Check out faer other work at pennharper.itch.io. - Cassidy Shard is played by Sydney Whittington. She is our wonderful editor. She's also a contributing editor and occasional guest player for the Orpheus Protocol, a cosmic horror espionage actual play podcast. Find her on Twitter at @sydney_whitt. - Emma Blackwood is played by Cameron Robertson. Find her on Twitter at @midnightmusic13 and on Instagram at @reading_and_dreaming. Cameron is also a player on Tabletop Squadron, a Star Wars Edge of the Empire actual play podcast. - Birdie Foundling is played by Kit Adames. Find her on Twitter at @venusvultures. Kit is also a voice actor and writer on Elevator Pitch Podcast, a queer genre-hopping anthology podcast that can be accessed on Spotify and YouTube. - Our GM and narrator is Nick Robertson. Find him on Twitter at @alias58. Nick is also the GM for Tabletop Squadron and can also be found as a player on the Orpheus Protocol.Music & Sound Credits: - This podcast features the musical talents of Dora Violet and Arne Parrott. You can find Dora at facebook.com/doraviolett. You can find Arne at atptunes.com. - old radio Channel search sound effect by Garuda1982. Link & License. - 12120 collapsing building.wav by Robinhood76. Link & License. - Riot Crowd Immersed in 5.1 Take 1 by MrProfDrDickweed. Link & License. - Sword Shing 19 by Department64. Link & License. - Rocky Roads by Stefano Vita. Link & License. - Rush by Crowander. Link & License.Art Credits: - The official artwork for this podcast was created by Rashed AlAkroka, who can be found on Instagram and Artstation @rashedjrs.Find Us Online: - Our Website - Twitter - Join our Patreon - Join our Discord
LIBERTY Sessions with Nada Jones | Celebrating women who do & inspiring women who can |
Dina Aronson is a writer, editor, and pro-age advocate who is passionate about shining a light on midlife women and reframing the cultural conversation around aging. A former attorney, law firm manager, and founder of a legal search consultancy, she pivoted careers at 51 after realizing how little content reflected her own evolving midlife experience. She began freelancing for startups focused on women over 40. Along the way, she founded the Patina blog, now a Substack newsletter called Patina with Dina Aronson, where she explores topics related to aging through her midlife lens. Dina is the coeditor of Midlife Private Parts: Revealing Essays that Will Change the Way You Think About Age, a soulful, unfiltered collection of stories that speak to what it really feels like to be a midlife woman in the world today. She sits on the Governing Board of the nonprofit America Needs You and on the Influencer Council of the nonprofit Uncommon Threads. Dina lives between New York City and Miami with her husband and is the proud stepmother of two grown sons. In today's episode, Nada talks with Dina about her new book of essays, “Midlife Private Parts.” Dina pursued this project to honor her mother's memory and legacy. Dina shares how she and co-author Dina Alvarez collected intimate stories about midlife with the hope that readers will feel less alone as they navigate their respective journeys. From learning to be vulnerable to giving up the need for control, the two reflect on the many aspects of life that become liberated in the middle third Check out “Midlife Private Parts” for more information on Dina's work. Follow on IG: @patina_life. Please follow us at @thisislibertyroad on Instagram; we want to share and connect with you and hear your thoughts and comments. Please rate and review this podcast. It helps to know if these conversations inspire and equip you to consider your possibilities and lean into your future with intention.
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