POPULARITY
Drs. Bose and Pemmaraju review secondary myelofibrosis arising from polycythemia vera or essential thrombocythemia and how it differs from primary myelofibrosis that develops de novo.
This week's episode will be re-discussing one of the myeloproliferative neoplasms, Polycythemia Vera (PV). We will go over the important details on the diagnosis, risk stratification for thrombus and treatment.
In this episode, we discussed the diagnosis and management of polycythemia vera with Dr. Aaron T. Gerds. Here are the shownotes with the key studies discussed: 1. MIPS PV scoring systemhttps://pubmed.ncbi.nlm.nih.gov/31945802/2. REVEAL studyhttps://ashpublications.org/blood/article/143/16/1646/506717/Association-between-elevated-white-blood-cell3. MAJIC PV studyhttps://ascopubs.org/doi/10.1200/JCO.22.01935?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed4. Cyto-PV Studyhttps://www.nejm.org/doi/full/10.1056/NEJMoa12085005. PROUD-PV and CONTINUATION-PV trialshttps://www.thelancet.com/journals/lanhae/article/PIIS2352-3026(19)30236-4/abstract6. RESPONSE clinical trialhttps://www.nejm.org/doi/full/10.1056/NEJMoa14090027. Rusferitide in PVhttps://www.nejm.org/doi/10.1056/NEJMoa2308809?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
In this episode, listen to Dr Brady L. Stein share his clinical insights and takeaways on new data for myeloproliferative neoplasms (MPNs) presented at the 2024 ASCO Annual Meeting and the EHA 2024 Congress including:Long-term survival adjusted for treatment crossover in patients with myelofibrosis (MF) treated with momelotinib vs danazol in the MOMENTUM trialEfficacy of pacritinib in patients with MF who have both thrombocytopenia and anemiaUpdated safety and efficacy data from the phase III MANIFEST-2 study of pelabresib in combination with ruxolitinib for JAK inhibitor–naive MFImpact of spleen volume on post-allogenic hematopoietic transplant outcomes in patients with MF: utility of 3D volumetrics in splenomegalyProgression to MF in patients with essential thrombocythemia: an analysis from the prospective MOST studyJAK2V617F molecular response correlates with event-free survival in a patient population with early polycythemia veraPhase III TRANSFORM-1 study: efficacy and safety of navitoclax combined with ruxolitinib vs ruxolitinib plus placebo in patients with untreated MFPatient characteristics, treatment patterns, and health outcomes in a real-world population of patients with MF treated with fedratinib Program faculty:Brady L. Stein, MD, MHSProfessor of MedicineDepartment of Hematology/OncologyNorthwestern University Feinberg School of MedicineChicago, Illinois Resources:To download the slides associated with this podcast discussion, please visit the program page.
On this special episode of the BloodStream Podcast, we explore interferons in the treatment of polycythemia vera (or PV). This episode is brought to you by PharmaEssentia. If you'd like to learn more about polycythemia vera, check out our sister show PV Pod: Stories from the Marrow (brought to you by BloodStream Media and PharmaEssentia). Connect with BloodStream Media: BloodStreamMedia.com BloodStream on Facebook BloodStream on Twitter
Dr Naveen Pemmaraju from The University of Texas MD Anderson Cancer Center in Houston discusses updated findings from ASH 2023 on management approaches for myelofibrosis and polycythemia vera, moderated by Dr Neil Love. Produced by Research To Practice. CME information and select publications here (https://www.researchtopractice.com/OncologyTodayPostASH24/MPN).
Dr. Harris speaks on PV
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This week we bring you a two-in-one! We cover polycythemia vera and essential thrombocytosis. Written by: Dr. RuiQi (Richard) Chen (Internal Medicine Resident) Reviewed by: Dr. Hassan Sibai (Hematology) and Dr. Christopher Langlois (GIM)Support the show
In this week's podcast, "Tyre'd but not out" we are very pleased to have a very special guest Keith Ambrose.Kieth is a local (to us) very successful businessman, owner of the company "Treadfirst" with a number of outlets across East Anglia in the United Kingdom.There are over 200 different types of Cancer worldwide and today we discuss with Keith one very rare Cancer known as "Polycythemia Vera"Keith openly and honestly tells of his pre-diagnosis conditions, how for three years he struggled to get to a point when a full and complete diagnosis was eventually made, and his procedures and ongoing treatment to the present day.This truly is a remarkable story and such an addictive listen, an insight into one of the rarest Cancers today of which we still know very little.Keith's Cancer study made a new ground-breaking discovery in the understanding of Polycythemia Vera which astounded the leading Professor in this field.Note: We appreciate the word Tyre'd in the title is spelled incorrectly, but it relates to Keith's business which involves Tyres.Check out our new website at www.whostomanddick.com
This week's episode will be focusing on another one of the myeloproliferative neoplasms (MPN): Polycythemia Vera (PV). We will go over the important details on the diagnosis, risk stratification, and treatment.
In this week's episode, we'll discuss new evidence on the critical role of hepcidin, the master regulator of iron metabolism, in the pathogenesis of polycythemia vera. Next, costimulatory molecules regulate mechanisms of CAR T cell dysfunction. Finally, we'll discuss how TREM2 is a novel receptor for IL-34, promoting differentiation of normal and leukemic myeloid cells.
Dr. Barbara Abernathy is the President and CEO of The Pediatric Oncology Support Team, (POST) serving South Florida. She was already working at POST, helping pediatric cancer patients and their families, when she herself was diagnosed with Polycythemia Vera, a blood cancer, in 1996. She kept her diagnosis to herself.In 2013, Barb's disease morphed into AML, and she was in urgent need of a bone marrow transplant. A match, a young man in Germany, was found. Barb's intimate knowledge of cancer treatment proved both blessing and a curse. She quite honestly was more afraid of Graft Versus Host Disease (GVHD) than she was of dying from the transplant.After her bone marrow transplant at Moffitt Cancer Center in Tampa, she dealt with acute GVHD of the eyes, gastrointestinal system (GI system), skin, and liver. Her acute GVHD rolled right into chronic. Her existing symptoms persisted, including hair loss due to alopecia. People assume she's still in treatment because of the hair loss.Barb is very honest about the challenges of living with GVHD. Not being able to sweat in Florida requires a lot of planning and care. There was also the isolation during the pandemic. Fatigue is also an issue. Sometimes it's challenging just to keep the house clean. This affects her desire to have friends over; it's not that she doesn't want to see them!Her personal experience has led to greater connections with her patients. She's walked the walk and can talk the talk. Barb talks about the importance of advocating for yourself or your child with your medical team. We also spend some time on how friends and family can help. Sometimes it is as easy as changing the plan to better accommodate the survivor--maybe a breakfast date instead of a dinner date. It's important to LISTEN and not just offer something you think they need. Peer support is also key. Between patients and her own journey, Barb has many years of experience with GVHD. She talks about the new advances in therapy, how far we've come, and how it's given her hope for future treatment.Barb's nonprofit, Pediatric Oncology Support Team (POST) Website: https://postfl.org/Other ResourcesNational Bone Marrow Transplant Link - (800) LINK-BMT, or (800) 546-5268.nbmtLINK Website: https://www.nbmtlink.org/nbmtLINK Facebook Page: https://www.facebook.com/nbmtLINKnbmtLINK YouTube Page can be found by clicking here.Thank you to this season's sponsors:Supported by Pharmacyclics, an AbbVie Company (https://www.pharmacyclics.com/) and Janssen Biotech, Inc. (https://www.janssen.com/)Incyte: https://www.incyte.com/
In this podcast episode, Prithviraj Bose, MD, and Andrew Kuykendall, MD, discuss their contemporary approaches to the treatment of patients with essential thrombocythemia. The topics covered include:When to use cytoreduction therapies and which therapies to use in low-risk patientsType 1 and type 2 CALR mutations and addressing patient concerns with data from sequencing reportsExperts' thoughts on therapy options in higher-risk patientsPresenters:Prithviraj Bose, MDAssociate ProfessorDivision of Cancer MedicineDepartment of LeukemiaThe University of TexasMD Anderson Cancer CenterHouston, TexasAndrew Kuykendall, MDAssistant Professor Department of Oncologic SciencesUniversity of South FloridaAssistant MemberMalignant HematologyH. Lee Moffitt Cancer CenterTampa, Florida Content for this program was supported by educational grants from GSK, Incyte Corporation, and PharmaEssentia Corp.Link to the full program, including downloadable slides and an on-demand webcast from the live event:bit.ly/3XF3cSF
In this podcast episode, Raajit Rampal, MD, PhD, and Brady L. Stein, MD, MHS, discuss their contemporary approaches to the treatment of patients with polycythemia vera. The topics covered include:Patient presentation and goals of frontline therapyConsiderations for second-line therapy in the setting of treatment intoleranceExperts' thoughts on the potential of early intervention to alter disease progressionPresenters:Raajit Rampal, MD, PhDAssociate MemberAssociate Attending PhysicianLeukemia ServiceDepartment of MedicineMemorial Sloan Kettering Cancer CenterNew York, New YorkBrady L. Stein, MD, MHSProfessor of MedicineDepartment of Hematology/OncologyNorthwestern University Feinberg School of MedicineChicago, IllinoisContent for this program was supported by educational grants from GSK, Incyte Corporation, and PharmaEssentia Corp.Link to the full program, including downloadable slides and an on-demand webcast from the live event:https://bit.ly/3X3x6jX
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Welcome back to our weekend Cabral HouseCall shows! This is where we answer our community's wellness, weight loss, and anti-aging questions to help people get back on track! Check out today's questions: Zoe: Hi there! Just listened your episode “how to cure constipation” as I am constipated right now. You mentioned that you would recommend an international cleanse. I didn't see the brand in the show notes. Could you please tell me which brand you recommend for that? Also I have already purchased the 21 day detox. Should I do a intensional cleanse first and then detox? Or is it okay to just start with the detox? I am getting my hormonal birth control out on the 22nd so I was planning on starting the detox on the day of removal or next day. Anonymous: Dr. Cabral, by the time you answer this, I will have completed the CBO protocol and likely be continuing through the CBO Finisher. I am currently beginning month 3 of the CBO and have a need for more improvements in my constipation/trapped gas symptoms. I have been very diligent, and followed the protocol exactly as recommended. I tried the intestinal cleanse on week 6 and experienced the constipation and lack of motility in over two years, and I took the binder and 4 capsules 3x per day for 5 days with only one bowel movement. If this protocol does not provide any improvements, where do I go from here? What testing do you recommend? (I did the HMTA and Stool Test leading into the CBO). Thank you!! Samantha: Hi Dr. Cabral, Thank you for all that you do! I would love your insight. I'm a 30-year-old woman from New York. I recently had surgery on my right side Bartholin gland. I had an allergic reaction to either the anesthesia or intravenous antibiotics they gave me during the procedure. I'm seeing an allergist in a few weeks to figure that out. I had dermatitis that spread all over my torso, chest, arms, and back; it was pretty severe. A dermatologist prescribed me a ten-day taper protocol of Prednisone (which was really intense!). At the time of writing this, I'm done with the Prednisone and the bumps from the allergic reaction are gone, but I'm still SO itchy and I'm breaking out in hives. The itching feels like it's coming from the inside out if that makes sense. Actually scratching the area doesn't provide relief. I've been diagnosed with mast cell activation syndrome and I'm listening to your previous podcasts about it now. I've also been taking allergy medication and eating a low histamine diet. This combination provides very slight relief. I feel hopeless and want to feel like myself again. Thank you for any guidance that you may have. With Gratitude, Samantha Stefanie: Hi Dr. Cabral, You are truly amazing! I love all that you do and am so appreciated for finding equi.life and these podcasts! You are a blessing I have had hypothyroidism and addison's disease for 5 years. Recently my doctor discovered that I also have Polythemia Vera. In your experience have you seen all of these diseases to be related? I'm trying to find the right direction on how to naturally lower my red blood cell count without having to take blood medication to lower this. Have you worked with patients with polythemia vera? I would love any advice on where to begin healing this blood disorder. Cassie: Hi Dr Cabral. Thank you for all you do for everyone here. It's appreciate by so many of us! I have this “anxiety rash” is what my doctor labeled it as, but it happens with any heightened emotion, happy or sad and when I'm nervous. It starts on my neck and moves to my chest and when it's really bad it goes to my arms. Splotches on my face can appear too and my cheeks are always sort of red anyways. Sometimes a trigger is as simple as a customer at work complimenting me, and I feel it happening, which I don't really understand. Or being excited about something. Not all the time, but sometimes it can feel like a rush of adrenaline. It's come to the point where I feel uncomfortable in my own skin and I've hidden it for years by not wearing shirts or anything that goes below my collar bones or people always ask what's wrong. I'm getting married this summer and it makes me nervous I'm going to be a red mess because I know I'll feeling all the emotions that day. Doctors have just thrown anxiety meds at me, and that is not what I'm looking for. I am a very active person, exercise a lot and eat pretty healthy, I have noticed the healthier I eat the better it is but I can't figure out triggers with food. Any advice is so greatly appreciated! Thank you, Cassie Marleen: My bloodwork showed high B12 but I don't supplement how is this possible? Thank you for tuning into today's Cabral HouseCall and be sure to check back tomorrow where we answer more of our community's questions! - - - Show Notes and Resources: StephenCabral.com/2346 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? 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This is the third installment of the Cancer History Project's series in honor of Cancer Survivors Month. Dr. Deborah Doroshow, Cancer History Project guest editor during the month of June, conducted the following interview with Dave Boule, who was diagnosed with polycythemia vera in 2006. Soon after Boule was diagnosed, he had a hunch that there were better treatment options than the phlebotomies his New York doctor was treating him with. Boule did his research, and stumbled upon studies written by Dr. Richard T. Silver, who is now director emeritus of the Richard T. Silver MD Myeloproliferative Neoplasms Center. Silver's studies demonstrated that interferon would be the best treatment for his disease. Since then, Boule has undergone successful treatment with interferon, which he still takes today. His advice to newly diagnosed patients with myeloproliferative neoplasms: seek out a doctor who specializes in the disease. A transcript of this episode is available here: https://cancerhistoryproject.com/article/dave-boule-confronted-polycythemia-vera-with-an-accountants-consistency/
Jeremy Moberly was diagnosed with Polycythemia Vera in 2018 and is statistically on the younger end of the typical MPN Patient. We talk with Jeremy about his initial reaction to the diagnosis and how he has changed his life to live in this New World.We also talk about the importance of diet and exercise as well as how a thirty something MPN Patient deals with dating and sharing his situation with potential life partners.
In this episode, we review the high-yield topic of Polycythemia Vera from the Oncology section. Follow Medbullets on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbulletsIn this episode --- Send in a voice message: https://anchor.fm/medbulletsstep1/message
Anne Lynn Su Chang, MD interviewed by Vesna Petronic-Rosic, MD, FAAD
Joanne was diagnosed with Polycythemia vera in 2012. She shares her experience with her diagnosis, the support she received from local groups and how it has changed her life.
Join us as we speak with David Wallace, a polycythemia vera (PV) patient and advocate. In this episode, David shares… The post Pushing for a Diagnosis: A Polycythemia Vera (PV) Story first appeared on The Bloodline with LLS.
Join us as we speak with David Wallace, a polycythemia vera (PV) patient and advocate. In this episode, David shares… The post Pushing for a Diagnosis: A Polycythemia Vera (PV) Story appeared first on The Bloodline with LLS.
In this episode, Amy E. DeZern, MD, MHS, and Srdan Verstovsek, MD, provide medical oncology and hematology perspectives on new data from ASH 2020 in MDS and MPNs, with topics including:3-year OS results with RIC allogeneic transplantation in patients with higher-risk MDS in the BMT CTN 1102 studyA post hoc analysis of phase II data on the addition of pevonedistat to azacitidine in higher-risk MDS patients5-year results of ropeginterferon α-2b in polycythemia vera from the CONTINUATION-PV studyPhase II results of luspatercept for anemia in patients with myelofibrosis who are transfusion dependentAnalysis of clinical benefit in patients with myelofibrosis and OS benefit from imetelstat.Presenters:Amy E. DeZern, MD, MHSAssociate ProfessorOncology and MedicineThe Johns Hopkins University School of MedicineBaltimore, MarylandSrdan Verstovsek, MD, PhDZProfessorDivision of Cancer MedicineDepartment of LeukemiaThe University of Texas MD Anderson Cancer CenterHouston, TexasContent supported by educational grants from Amgen; AstraZeneca; Bristol-Myers Squibb; Epizyme, Inc; GlaxoSmithKline; Incyte Corporation; Janssen Biotech; Karyopharm Therapeutics Inc; Novartis; PharmaEssentia Corp; Seattle Genetics; and Takeda Oncology.Link to full program and Capsule Summary downloadable slidesets:http://bit.ly/3tyQ9nG
This episode covers polycythemia vera!
Listen to MPN expert Dr. Krisstina Gowin, Assistant professor of medicine in the division of Hematology/Oncology at the university of Arizona Cancer Center, and renowned comic book artist J.G. Jones discuss important topics for those living with an MPN, like the value of education and ways to work with your Healthcare Professional to be an advocate for your health. Dr. Gowin, J.G. Jones, and host, Gina, will also discuss the value of an individualized approach for patients with MPNs.Register now for useful MPN information and resources See the Rare Reflections: MPNs Unmasked series
EHA25 highlights: EHA President John Gribben talks AML, myeloma, polycythemia vera, and COVID-19 What were the late-breaking and practice-changing presentations at EHA25 Virtual? John Gribben, MD, DSc, president of the European Hematology Association, highlighted some of them in this podcast. Dr. Gribben and host David H. Henry, MD, discussed presentations on acute myeloid leukemia (AML), multiple myeloma, polycythemia vera (PV), and COVID-19. Videos of these and other presentations will be available on the EHA25 website until Oct. 15. Randomized, double-blind, placebo-controlled study of venetoclax with azacitidine vs. azacitidine in treatment-naïve patients with acute myeloid leukemia ineligible for intensive therapy—VIALE-A: Adding venetoclax to azacitidine improved survival, response, and transfusion independence in older patients with treatment-naïve AML. Older AML patients have seen “very little progress” in outcomes for decades, but advances such as these are “really moving the field,” Dr. Gribben said. Abstract LB2601: https://rb.gy/fou9jp Presentation: https://rb.gy/mmwn6s Phase 2 randomized trial comparing ropeginterferon versus phlebotomy in low-risk patients with polycythemia vera. Results of the pre-planned interim analysis: Ropeginterferon was safe and more effective than phlebotomy for keeping hematocrit on target in patients with low-risk PV. These findings suggest ropeginterferon is a viable option for PV patients, but “old-fashioned phlebotomy can also be quite efficient,” Dr. Gribben said. Physicians will have to weigh the risks and benefits, including cost-effectiveness, of each treatment, he added. Abstract LB2602: https://rb.gy/uicnmo Presentation: https://rb.gy/sj60ia Isatuximab plus carfilzomib and dexamethasone vs carfilzomib and dexamethasone in relapsed/refractory multiple myeloma (IKEMA): Interim analysis of a phase 3, randomized, open-label study: Adding isatuximab to carfilzomib-dexamethasone improved progression-free survival and time to next treatment. Overall survival data are not mature. The study was stopped early because the primary endpoint was met, as isatuximab “clearly demonstrated superiority,” Dr. Gribben noted. It isn’t clear how isatuximab stacks up against daratumumab, but these results suggest “people now have another CD38 antibody to consider as part of their armamentarium,” Dr. Gribben said. Abstract LB2603: https://rb.gy/gmxcgk Presentation: https://rb.gy/v209ol Endotheliopathy in COVID-19 associated coagulopathy This study showed “very clear evidence” of endothelial damage contributing to coagulopathy among severely ill patients with COVID-19, Dr. Gribben said. Endothelial cell and platelet markers were elevated in COVID patients who required intensive care, and soluble thrombomodulin was linked to survival. These findings prompted the decision to give all COVID patients aspirin. Abstract LB2605: https://rb.gy/sdc9dv Presentation: https://rb.gy/nxvpxj Iron metabolism in health and disease (Plenary I) This presentation suggested inflammation-induced hypoferremia can predict disease severity in COVID-19 patients. The presenter posited that iron accumulation in macrophages may increase inflammation and contribute to organ damage in COVID patients. “You can imagine a whole cascade of events that this virus triggers off,” Dr. Gribben said. Presentation: https://rb.gy/5lz3d6 Disclosures: Dr. Gribben reported relationships with Janssen, Celgene, Bristol Myers Squibb, AstraZeneca, AbbVie, Roche, Genentech, and Acerta Pharma. Dr. Henry reported having no disclosures relevant to this episode. * * * For more MDedge Podcasts, go to mdedge.com/podcasts Email the show: podcasts@mdedge.com Interact with us on Twitter: @MDedgehemonc David Henry on Twitter: @davidhenrymd
Hear from an MPN expert—plus a group of real MPN patients! Learn about polycythemia vera, myelofibrosis, and essential thrombocythemia—the rare, chronic blood cancers known as myeloproliferative neoplasms, or MPNs. Listen to Andrea Larson from Incyte Corporation talk with Incyte oncology clinical nurse educator Paul Larson about important topics for people living with MPNs, like tracking symptoms to watch for signs of disease progression. Also hear from Wilma, Marilyn, Dave, and other members of the Voices of MPN community who share their own personal MPN experiences.Learn more about tracking your MPN over time Receive resources to help you better understand and promote awareness of MPNs The content presented in this podcast is not medical advice and should not replace a conversation with your Healthcare Professional, who is the best source of medical information about your individual diagnosis and management plan.
Thank you for joining us for our 2nd Cabral HouseCall of the weekend! I’m looking forward to sharing with you some of our community’s questions that have come in over the past few weeks… Let’s get started! Alex: Dr. Cabral, thank you so much for your work. The info and protocols you share have literally given me my life back. I listened to your podcast on lectins and need some clarity. The Organic Acids test confirmed some yeast and bacteria overgrowth, and I am currently on month two of the CBO protocol. I did not have any parasites, hpylori or clostridia. I do not want to eat poultry/meat for welfare standard issues, and seafood is not very appetizing to eat (except wild salmon). Thankfully I am not allergic to eggs, so this has been my main source of protein. I noticed the vegan proteins on the sensitive gut guide are mainly legumes. Hemp hearts are great but leave me very hungry in between meals. I have been trying lentils and chickpeas, but still have painful and explosive gas which goes away when I eliminate legumes. I did not have any IGG sensitivities to legumes, but have avoided them for years due to symptoms. Should I rerun the food sensitivity and eat legumes the day before the test? Also, once I complete the CBO protocol would it be possible to digest these vegan legumes? I heard from another source that it's because there is not the bacteria present to breakdown the legumes, but adding certain strains of bacteria can help with digestion. I am wondering if the CBO probiotics will repopulate the gut with these bacteria. Should I try again, is there anything I can do to add these vegan proteins back into my diet or am I just to avoid them for life and occasionally eat poultry/meat to keep protein intake at a decent level? Thanks again Chanel: Dear Dr. Cabral, I am a new listener and have loved every minute. I appreciate your analytical, but practical and caring approach. I also appreciate how you put yourself in the listener’s shoes. Every day, I try to learn more about the microbiome and natural health by reading, listening to podcasts, docuseries, etc. I am writing in to obtain your perspective and guidance. My family and I are on a health journey. We’ve made a lot of changes over the last 1 ½-2 years. I’ve suffered with some health conditions and have made many diet & lifestyle changes in order to improve my health. I still have some things to work on and my goal is to include as many natural/holistic methods as possible in order to regain my health and may write in about my health challenges at a later date. My husband is in the process of making changes too. Most importantly, our three daughters (ages 5, 8 and 12) have been the catalysts for our diet & lifestyle shifts. I am writing in about our girls, primarily my middle daughter. I apologize in advance for the length of this email but will try to condense everything. I’ve been able to look back in hindsight and realize some of the things that brought us to this point. In 2017-2018, we incorporated a lot of wheat in our diet. I thought that was the healthier thing to do so we traded white bread and pasta, etc. for wheat. This, along with an overall less than nutritiously dense diet, regular antibiotic prescriptions, hectic lifestyle, etc. more than likely, contributed to the decline of their gut and digestive health. Our children began to experience many health and digestive issues. Not long after this “wheat swap”, my oldest daughter began to randomly break out in hives. My youngest was diagnosed with GERD and then my middle was diagnosed with GERD along with other conditions. My middle daughter also experienced continuous reflux, stomach pain, bloating, nausea, headaches…you name it! These things heightened last spring; traditional medicine, doctors and specialists were not able to help us and may have set us back with acid blockers. This was a very hard time for our family and for me as a mother as I watched my children suffer. My middle daughter had a feeling of malaise, had low energy and was just not herself. She was also having moments of getting hot/flushed, with rapid heartbeat, headache, stomachache, dizziness, etc. We saw a naturopathic doctor in the spring 2019 and she was very helpful at the time. I also ordered a Diagnostic Solutions GI Map stool test from another practitioner for my middle daughter and the results showed high opportunistic bacteria, extremely low Sec IgA and low normal/”good” bacteria. We were put on a protocol and after treatment, things improved, but my younger two daughters take Miralax to prevent constipation. We removed gluten and dairy and embraced a whole-food, plant-based diet, incorporating organic, grass-fed & finished meats, etc. basically removed most candy & sugar, improved hydration and sleep, as well as slowed down our lifestyle. I thought that we were done with health issues, but my younger two daughters were diagnosed with lichen sclerosis (after many doctor & specialist visits) during the summer of 2019. We recently began seeing another holistic practitioner. She’s been helpful and we’ve incorporated supportive supplements to provide key nutrients that their bodies were missing, as well as some natural based prevention methods. This practitioner uses a Zyto energy scan. I’m skeptical of the scan and don’t fully understand it, but felt it had low risk and low cost so it was worth a try. My daughters and myself had the scan done and the results showed many different types of viruses (to include lyme and co-infections), bacteria, fungi, metals, parasites, microbes, mold, dysbiosis, etc. for all of us. However, my middle daughter is starting to experience some of the same symptoms as last spring, but to a lesser degree. I am very concerned to say the least. I feel that gut & digestive repair is a big piece to this puzzle. She’s had many other symptoms too, such as skin rashes, peeling and itching, an ulcer on her gum, and most recently, we’ve been referred to the children’s orthopedic department for unexplained ankle pain and knee pain that significantly impacts her mobility and to neurology for tingling on the bottom of her feet. I realize that this a lot of information, but I wanted to give you some background on my children. Another MRI was ordered, along with some labs. I’ve ordered your OAT for all of my girls, along with your stool, mold and toxicity tests for my middle daughter. We want to be through and comprehensive in our approach. We don’t want to return to this place of ill-health ever again. I know you can only give advice, but if this were you & your daughters, what would you do? We are desperate to rebalance the body and restore health to my child. We live in a rural community and there are not many practitioners that explore and practice natural-based medicine, along with comprehensive testing. Needless to say, our lives have been disrupted and we’re looking to find a place of peace. I realize you won’t be able to answer this immediately, but wanted your direct feedback.Concerning my middle daughter: *What else could/should we be evaluating or exploring-tests or labs? *What do we do in the meantime while we wait on test results? *Do some of these symptoms sound like an issue with the vagal nerve or gastroparesis? *What are your thoughts on the energy/Zyto Scan? *How would I know if we actually have all of the microbes, infections, bacteria and viruses, etc. reported from the energy scan and the best protocol to treat these things? Where do we start? Please help. Any guidance and/or direction is appreciated. Thank you for your time. ~Chanel Anthony: Hi Dr. Cabral, I’m a big fan and have been listening to you since you were interviewed by the MindPump crew. My wife is in her mid-40’s. She normally has difficulty sleeping however it has gotten worse over the past 6 months. Typically, it lasts around a week and is right before she gets her period. We both believe it is hormonal , common, but not normal. I searched previous podcasts and didn’t find anything. Hoping you can shed some light on the possible etiologies and point is in the right direction. Keep up the great work and thank you for all of the knowledge that you share. Happy Holidays! Anthony Rose: Does too much sugar in older mans diet effect his prostrate levels?? Anonymous: Dr. Cabral, I am writing to let you know that I would love to have you record a follow up to podcast #1306:Mystery Illness Solved:Client Case Study (TWT). My story is similar to your complicated client in that I was diagnosed with a Myeloproliferative cancer in January 2018. I have primary myelofibrosis with a component of Polycythemia Vera (needing an occasional phlebotomy due to hematocrit >45). I also have a history of Hashimotos Thyroiditis (currently on watch and wait) and reflux diagnosed a few years before. I have never had any other health problems in my life andI have been fairly active and healthy. November 2017 when my abnormal bloodwork was found I started an Anti-inflammatory diet and was ultimately able to bring my TPO antibodies from 150 to 70 and heal my reflux. Unfortunately as I continued trying for the next year to heal myself I was not able to improve my blood work with the myelofibrosis. In November 2018 I began working with a Functional Medicine practitioner and he found that I had high levels of mycotoxins, mercury, gut dysbiosis, and parasites. For the next year we worked to resolve and eradicate everything we found with the necessary protocols. I have been dry brushing, juicing, sauna sessions, coffee enemas, DCD, intermittent fasting, weekly 24 hour fast, supplementing, and on a anti-inflammatory diet. I even enrolled in IHP level 1 and 2 in January 2019 in order to further my education. I was trained in conventional medicine as a Physician Assistant and now I feel I could never practice the same way again due to what I have learned in experiencing this health journey. I feel better than I ever have in the past 20 years, the problem is, is that the Myelofibrosis continues to progress and we are at a point where my oncologist is suggesting I need to start on low dose chemotherapy. SO....I would love to hear what you found with your client and how you approached it and your results. I am so thankful for finding you and your wonderful community. Your positive demeanor and messages inspires me in my journey. Thank you for all you do. Rose: Hi, I had my thyroid removed over 25 years ago {goiter growth} I"m on thyroid med. My metabolism is slow. It take my food so long to digest. Im thin 110-115# 66 years. Can you help with this? Thank you Thank you for tuning into this weekend’s Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right! - - - Show Notes & Resources: http://StephenCabral.com/1430 - - - Dr. Cabral's New Book, The Rain Barrel Effect https://amzn.to/2H0W7Ge - - - Join the Community & Get Your Questions Answered: http://CabralSupportGroup.com - - - Dr. Cabral’s Most Popular Supplements: > “The Dr. Cabral Daily Protocol” (This is what Dr. Cabral does every day!) - - - > Dr. Cabral Detox (The fastest way to get well, lose weight, and feel great!) - - - > Daily Nutritional Support Shake (#1 “All-in-One recommendation in my practice) - - - > Daily Fruit & Vegetables Blend (22 organic fruit & vegetables “greens powder”) - - - > CBD Oil (Full-spectrum, 3rd part-tested & organically grown) - - - > Candida/Bacterial Overgrowth, Leaky Gut, Parasite & Speciality Supplement Packages - - - > See All Supplements: https://equilibriumnutrition.com/collections/supplements - - - Dr. Cabral’s Most Popular At-Home Lab Tests: > Hair Tissue Mineral Analysis (Test for mineral imbalances & heavy metal toxicity) - - - > Organic Acids Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Thyroid + Adrenal + Hormone Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Adrenal + Hormone Test (Run your adrenal & hormone levels) - - - > Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Omega-3 Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - > Stool Test (Use this test to uncover any bacterial, h. Pylori, or parasite overgrowth) - - - > Genetic Test (Use the #1 lab test to unlocking your DNA and what it means in terms of wellness, weight loss & anti-aging) - - - > Dr. Cabral’s “Big 5” Lab Tests (This package includes the 5 labs Dr. Cabral recommends all people run in his private practice) - - - > View all Functional Medicine lab tests (View all Functional Medicine lab tests you can do right at home for you and your family)
Take a deep dive into common CBC abnormalities. We recorded LIVE at joint grand rounds between Walter Reed NMMC and Uniformed Services University with hematologist, Dr. Mary Kwok MD. Topics include: which parts of the complete blood count (CBC) are most important, interpreting the differential, when to order flow cytometry, who needs a hematology consult and simplified approaches to patients with leukocytosis, leukopenia, erythrocytosis and thrombocytopenia. Full show notes at https://thecurbsiders.com/podcast. Join our mailing list and receive a PDF copy of our show notes every Monday. Rate us on iTunes, recommend a guest or topic and give feedback at thecurbsiders@gmail.com. Credits Written, Produced and Edited by: Matthew Watto MD, FACP Cover Art and Infographic by: Matthew Watto MD, FACP Hosts: Stuart Brigham MD; Matthew Watto MD, FACP; Paul Williams MD, FACP Guest: Mary Kwok MD Sign Up for a course w/our Chief of POCUS, Dr. Renee Dversdal! ACP - acponline.org/pocus AIUM - Check out https://aium.org for upcoming events. TRUST (Train the Ultrasound Trainers) https://www.ultrasoundtraining.com.au/courses/category/train-the-ultrasound-trainer-trust Time Stamps 00:00 Intro; Paul shame’s the audience; Guest bio 03:17 Guest one-liner, book recommendation* -Emperor of All Maladies (book) by Siddhartha Mukherjee, When Breath Becomes Air (book) by Paul Kalanithi; Career advice -set goals for whatever you’re learning. 08:43 Picks of the week: John Wick 3 (film); The Movies That Made Me (podcast) by Joe Dante; The Tim Ferriss Podcast with Julie Rice of Soul Cycle; Infinity Chamber (film) by Travis Milloy 11:50 A case of asymptomatic leukocytosis; Red flags; Repeat the CBC until it’s normal 17:30 The peripheral smear; Leukemoid reaction 20:00 The physical exam; When to send flow cytometry? 22:18 A case of lymphopenia; benign ethnic neutropenia; What to look for in the history 27:10 A case of erythrocytosis; Checking EPO levels; JAK2 mutation; Differential Diagnosis; Therapeutic Phlebotomy; Physical findings of Polycythemia Vera 36:53 A case of thrombocytopenia; Lab workup; Differential diagnosis; Pathophysiology; Culprit meds 45:35 Advice for internists 46:36 Take Home Points 47:46 Dr. Kwok’s disclaimer 48:10 Outro and post credit scene
MPN Chronicles Podcast – 04, PV Reporter, Always Ask Your Doctor for your CBC or your test results and keep a binder to Monitor your Progress by David Wallace After 2 visits to the ER, I finally had my first hematologist meeting. She reviewed the tests that were done in the ER and ran a […]
MPN Chronicles Podcast – 04, PV Reporter, Always Ask Your Doctor for your CBC or your test results and keep a binder to Monitor your Progress by David Wallace After 2 visits to the ER, I finally had my first hematologist meeting. She reviewed the tests that were done in the ER and ran a […]
Marginal Zone Lymphoma CancerCare Connect Education Workshops
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Diffuse Large B-Cell Lymphoma CancerCare Connect Education Workshops
MPN Chronicles Podcast – 03, PV Reporter, Day 3, 2nd Trip to ER in 3 Days by David Wallace Chest pain continued to worsen after 1st trip to the ER, 2 days earlier. This was an immediate cause for immediate concern and a return trip to the ER on day 3 with Polycythemia Vera (PV). […]
MPN Chronicles Podcast – 03, PV Reporter, Day 3, 2nd Trip to ER in 3 Days by David Wallace Chest pain continued to worsen after 1st trip to the ER, 2 days earlier. This was an immediate cause for immediate concern and a return trip to the ER on day 3 with Polycythemia Vera (PV). […]
MPN Chronicles Podcast This podcast will cover the PV journey I endured since day 1 of diagnosis at the Mint Hill Urgent Care, the days spent with chest pain that felt like a heart attack was “coming soon.” I will discuss my trip to the Emergency Room and the frustration that followed in trying to […]
MPN Chronicles Podcast This podcast will cover the PV journey I endured since day 1 of diagnosis at the Mint Hill Urgent Care, the days spent with chest pain that felt like a heart attack was “coming soon.” I will discuss my trip to the Emergency Room and the frustration that followed in trying to […]
You Are Not Your DiagnosisWhat is your disorder? *polycythemia veraAt what age did your disorder become a daily issue? *25Who were you before your illness became debilitating? *I was a graduate student pursuing a career in academia but I was completely miserable on my path.What would you do if you were not dealing with your invisible illness? *I don't know that I'd be doing much different other than maybe having a bit more energy in generalWhat would you like people to know about your daily life? *That through alternative healing methods, I'm able to live a normal life- one that I didn't think was possible back when I was diagnosed in 2004 (which was actually a misdiagnosis)What would make living and moving in the world easier for you? *If doctors would understand the power of their words and their attitudes in how people get better or stay sick. If alternative healing was more embraced by people, especially doctorsDo you have any life hacks? *Tons. One of my favorites is self-care, especially something called BodyTalk Access. Others include focusing on my mindset/thoughtsWhat kind of support do you get from family or friends? *I've always had pretty good support. Initially, the challenge was my diagnosis became the topic of EVERY conversation and I felt that was who I had become. But now many people don't see me that way. Close family knows some of my challenges.Have you ever had someone not believe you have an invisible illness because of your appearance? *I've never had someone say that to me but I don't tend to want people to know my health historyHow has your invisible illness affected your relationships? *At times it put me in the position of feeling dependent on my parents for help, support, etc. Living with a husband who was diagnosed with RA and Sjogren's last year (which isn't something he's yet told many people about) can be challenging on days when I feel tired and he's hurting.What is your best coping mechanism? *taking time to center myself, breathe, ground, do self-careWhat are you the most concerned about and the hopeful for in the future? *Fearful would be that things could get worse. Hopeful that the tools that have already given me so much of my health back and completely eliminate the diseaseWhat is your favorite swear word?I didn't use to feel this way but now it is fuckAny questions you think we should add to this list?What is the hardest and/or best lesson your condition has taught you?The best lesson is that being scared of the unknown and stuffing down my feelings, fears, etc didn't help anything but made things worse. I learned my body has a lot of wisdom that I can tap intoYou Are Not Your DiagnosisBio-FeedbackBody TalkIOS Calm appApple WatchInsight Timer See acast.com/privacy for privacy and opt-out information.
We are what we repeatedly do. Excellence, then, is not an act, but a habit. –Aristotle Welcome back to RoshCast for Episode 41! As we get closer and closer to the in-training, now would be a great time to go back and listen to old episodes to brush up on some of the core EM knowledge read more... The post Podcast Ep 41: Polycythemia Vera, Ischemic Hepatitis & More appeared first on RoshReview.com.
People are concerned about blood getting too thick on TRT. The good news is, new data has proven this isn’t the case! Why is it actually normal to have a hemoglobin level of 21? What other conditions is Polycythemia common in? What is the medical industry getting wrong about Polycythemia and TRT? On this episode, Dr. John Crisler talks about the importance of ferritin, tracking RDW and the falsehoods of testosterone replacement therapy. You don’t want to limit your blood by limiting your iron, because ferritin does a lot more for us than just carry iron for blood. -Dr. John Crisler Three Takeaways It’s generally thought that testosterone shots have a higher risk of thickened blood than creams and gels. Bloodletting lowers ferritin levels. Ferritin is important because it stores iron and is important in many other body functions. Breaking the relationship between the FDA and Big Pharma would be a good start for the new administration. At the start of the show, Dr. John shared the new data about Polycythemia and why it’s good news for people concerned about their blood getting too thick on TRT. He also talked about other conditions where Polycythemia can occur, and how altitude can increase your hemoglobin without posing health risks. He shared on the mindsets that are informing the medical industry’s attitude on TRT, and falsehoods about the treatment that aren’t helped by the healthcare model. Dr. John also shared insights on: Erythrocytosis vs. Polycythemia How people confuse Polycythemia and Polycythemia Vera The causes of a rise in platelets The health risks of bloodletting Why it’s important to track RDW TRT delivery systems and which one is more like to make blood thicker Synthetic drugs and their role in increased heart attacks and strokes How the internet has given us power over personalized healthcare When blood becomes thicker it carries more oxygen, and this was always thought to be a risk for people on TRT. With recent studies showing there’s no risk for this, men won’t need phlebotomies or bloodletting. This means you avoid the risk of lowering your ferritin levels. It’s also important for doctors to track other metrics aside from Polycythemia to get a clearer picture of what’s in your blood, and how at risk you are for strokes and heart attacks. Guest Bio "Dr John" Crisler is a world renowned author and expert on testosterone replacement therapy (TRT), having created several treatment protocols which have changed the way physicians everywhere care for their patients. There are good reasons why men have travelled to be seen by him from every state as well as dozens of foreign countries: "Dr John" successfully treats the tough cases. Go to allthingsmale.com for more information.
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Myeloproliferative Neoplasms CancerCare Connect Education Workshops
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Myeloproliferative Neoplasms CancerCare Connect Education Workshops
This podcast provides commentary on the importance of symptom assessment in Polycythemia Vera, and how this may impact therapeutic decision-making.
Frankly Speaking About Cancer with the Cancer Support Community
Only about 14,500 people in the U.S. will be diagnosed with an MPN this year, and the number for polycythemia vera, a type of MPN, is even less—about 22 cases per 100,000 people. On this episode of Frankly Speaking About Cancer, we'll learn more about polycythemia vera, as well as tips for managing a rare cancer.
Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 18/19
Aquagener Pruritus ist eine stark einschränkende Begleiterscheinung der Polycythemia Vera. Er ist gekennzeichnet durch ein stark juckendes, stechendes, kribbelndes oder brennendes Gefühl nach Wasserkontakt mit der Haut. Sichtbare Veränderungen zeigen sich nicht. Da er die Lebensqualität betroffener Patienten stark einschränkt und für einen Großteil der chronischen Beschwerden der Polycythaemia Vera verantwortlich ist, ist ein besseres Verständnis dieser Erscheinung für eine bessere Behandlung dringend erforderlich. Obwohl der aquagene Pruritus zuerst vor mehr als 40 Jahren beschrieben wurde, ist nur sehr wenig über die Pathophysiologie und Prävalenz bekannt. Ebensowenig ist bekannt über den Charakter, seinen Einfluss auf die Lebensqualität oder die optimale Therapie. Auch wenn der Juckreiz in manchen klinischen Studien, die die Polycythaemia Vera betreffen erwähnt wird, wird er überraschenderweise bei der Bewertung der klinischen Wirksamkeit von Medikamenten bisher noch vernachlässigt. Andere Marker, wie die Prävention thromboembolischer Komplikationen, Kontrolle des Hämatokrit oder Reduktion einer Splenomegalie werden üblicherweise als wichtigere Parameter der therapeutischen Wirksamkeit erachtet. Folglich wurde bislang der Einfluß des aquagenen Pruritus auf die Lebensqualität und damit die Notwendigkeit einer Behandlung weitgehend ignoriert. Deshalb haben wir uns entschlossen, die klinischen Eigenschaften des aquagenen Pruritus sowie seinen Einfluß auf die Lebensqualität an einer großen Kohorte deutscher Patienten mit Polycythaemia Vera mittels eines Patientenfragebogen zu untersuchen. 301 der 441 untersuchten Patienten litten an aquagenem Pruritus. Bei 64,8 % dieser Patienten trat er im Durchschnitt 2,9 Jahre vor der Diagnose der Polycythaemia Vera auf. Nur bei 15,4 % führte dies zu einer hämatologischen Untersuchung. Aquagener Pruritus tritt hauptsächlich am Körperstamm und den proximalen Extremitäten auf. Die meisten Patienten beschreiben ihn als Juckreiz (71,8 %), der Rest als kribbelnde, stechende oder brennende Empfindung. 44 Patienten (14,6 %) klassifizierten den Pruritus als "unerträglich". Patienten mit aquagenem Pruritus erzielten im EORTC-Lebensqualität-Fragebogen erniedrigte Werte bezüglich des Globalen Gesundheitsstatus. Sie litten auch mehr unter Fatigue, Schmerzen und Dyspnoe. Nur 24 % der Patienten erhielten eine gegen den aquagenen Pruritus gerichtete Therapie. Meist wurden Antihistaminika verschrieben, die die Symptome in gut der Hälfte der Fälle besserten. Bei 5,6 % der Fälle konnte eine PV-spezifische Therapie (Aderlässe, Zytoreduktion) eine Symptomfreiheit bewirken. Zusammenfassend ist der aquagene Pruritus ein ernstzunehmendes Symptom bei Patienten mit Polycythaemia Vera, das schwierig zu behandeln ist. Die Einführung der neuen JAK2-Inhibitoren könnte jedoch neue Therapiemöglichkeiten eröffnen.
Myeloproliferative Neoplasms CancerCare Connect Education Workshops
Myeloproliferative Neoplasms CancerCare Connect Education Workshops
What do Robert Rosen and Leighanne Littrell, wife of Backstreet Boys Brian Littrell, have in common? They both founded amazing charities to help people with life-threatening medical problems. Robert Rosen was diagnosed with Polycythemia Vera, a type of blood cancer and Brian Littrell was born with congenital heart disease. They have changed their ill-fate into something positive by dedicating themselves to relieving the suffering of others with these disorders.
Sat, 1 Jan 2005 12:00:00 +0100 https://epub.ub.uni-muenchen.de/16968/1/10_1159_000084372.pdf Hamann, Gerhard F.; Dichgans, Martin; Pellkofer, Hannah L.; Brüning, Roland; Opherk, Christian ddc