Podcasts about mscl

My So-Called Life lives again! This week, we're chatting about how MSCL was saved from oblivion, resurrected on cable. What made MTV such a perfect home for this show -- better, in fact, than the network where it originally aired? Joining me this week for a chat about MTV is the delightful Peppermint: Drag Race icon, actor, singer, and child of the 90s. Then I'll dive even further into the decade with James, in a conversation touching on David Bowie, adult animation, Clarissa Explains it All, and why James once spent a week wandering town in his underwear.Check out Peppermint's new book club with Hugh Ryan here, and her Drag PAC here.

In this week's episode of Matt's So-Cast Pod, it's the dramatic conclusion -- OR IS IT??? We've reached the final episode of My So-Called Life, in which everyone has revealing dreams and Brian finally tells Angela how he feels ... but she thinks that it's actually how Jordan feels. Meanwhile, Delia's got the hots for Rickie but has an important question to ask: Is he gay or what? And Graham and Hallie get a little steamy over a rack of lamb. Also, Patty meets Princess Diana.Diving into all this drama with me is the delightful Sam Pirie (Instagram, YouTube), returning guest and newcomer to MSCL. Now that he's watched the whole series, how does he like this tale of 90s woe, as a youngster who wasn't even alive when it aired?And -- what's next for the podcast? All will be revealed in my illuminating conversation with James!

Happy 1995! It's a new year, and time to make some resolutions ... which will almost immediately be broken. Angela wants to stop being so introspective (although on second thought, maybe not), Patty wants to stop being so suspicious, Danielle wants to wear makeup ... and Rickie wants a place to live, which puts everyone else's resolutions into perspective. Mr. Katimsky, recently having sworn off coffee, wants to help, but can't -- for reasons that will become SHOCKINGLY (for the 90s) clear.Breaking it down with me this week is Aaron Berman, author of the forthcoming book So Beautiful it Hurts: The Making of My So-Called Life. (Check out Aaron's MSCL community on Facebook here.)

We've reached episode 14, in which Rayanne is one month sober -- but alas, she's starting to get a little fidgety. Can Angela and Rickie keep her from slipping back into old habits? Especially now that Angela has her hands full trying to figure out what her relationship with Jordan has become. Meanwhile, Patty learns a thing or two about Kurt Vonnegut.Joining me to break it down is Aaron Berman, author of an upcoming book about My So-Called Life called So Beautiful it Hurts. (Check out Aaron's MSCL community on Facebook here.) And then James and I talk about our most horrifying on-stage humiliations before the spirit of Jimminy Glick overtakes us.

While Patty & Graham are away, Rayanne will... accidentally hand-cuff herself to their bed and everyone will spend the rest of the weekend trying to figure out how to set her free! We're on the penultimate episode of My So-Called Life: Episode 18 - Weekend. We also share some fun MSCL-related information and have another special guest for Show & Tell: Jennie Kwan (Sam Woo on California Dreams)!Our InstagramOur WebsiteOur FacebookOur TikTokAlternate SidesA movie podcast with a twistListen on: Apple Podcasts SpotifySupport the Show.Want to support the show? Become a subscriber here on Buzzsprout, or get exclusive content over on Patreon!

Carrie Gillogly, PhD, MSCL and television writer Richard Monahan join us this week to explore the inadequacies of the Pittsburgh school system and the general act of being annoying in the 90s.

We're taking a break from Degrassi to review all of the episodes of My So Called Life! If you're here for Degrassi content, there is a ton of it in the show archives. Just go back to previous episodes to get your Degrassi fix. And hopefully you'll stick around for reviews of My So Called Life as well! In our first MSCL episode, we're doing an intro to the show and getting everyone's first impressions. Then we're reviewing the first half of the pilot episode. Next week, we'll cover the second half. Big thank you to Debbie for joining us on this one! We're available on all of the standard podcasting platforms and can also be streamed on Spotify. Please give us a follow on Twitter NarbosPodcast or on Instagram and Tiktok @NarbosAndBroomheadsPodcast, and if you want to watch along, please send your comments to Narbosandbroomheads@gmail.com and we'll make sure to share them on future episodes. You can also join our Narbos And Broomheads Facebook group for information on live episodes being broadcast in the future. If you like the show, please shoot us a 5 star rating on iTunes, and tell all of your Degrassi loving friends!

In this episode we discuss getting mad at your mom, a sex offender list but for people who eat bagels Globetrotter-style, why Canada won't let us have certain shows, Jordan Catallano aka the prototypical dream man, feeling alt for watching "vintage" tv, Claire Danes quitting MSCL to go to skewl, teens thinking everyone wants to look at them, idolizing Rayanne, the 80's Frankenstein hairstyle, moms in teen shows, dads not being able to handle their teen daughters in towels (EEK), the utter humiliation of carrying a tray, the evolution of incels and SO MUCH MORE!!!

This week Val and Rachel sit down with our friend Nicole Restaino for an innovative new format: we'll be contrasting and comparing 90s TV show My So-Called Life with current HBO show Euphoria. Both shows depict teenagers with complexity and have passionate fan bases. We also finally break the one-hour mark, so hold onto your hats, dear listeners!   My So-Called Life is an American teen drama television series created by Winnie Holzman and produced by Edward Zwick and Marshall Herskovitz. It originally aired on ABC from August 25, 1994, to January 26, 1995. Set at the fictional Liberty High School in a fictional suburb near Pittsburgh, Pennsylvania called Three Rivers, it follows the emotional travails of several teenagers in the social circle of main character Angela Chase, played by Claire Danes. The show was officially canceled on May 15, 1995, despite being critically praised for its portrayal of adolescence and the commentary of its central character, Angela, and for receiving several major awards nominations, including Danes winning the Golden Globe for her acting work on the series. Besides Danes, the show also launched the careers of several other major actors of her generation, including Jared Leto and Wilson Cruz. Euphoria is an American teen drama television series created and written by Sam Levinson for HBO. It is based on the Israeli television miniseries of the same name created by Ron Leshem and Daphna Levin. The series follows a group of high school students through their experiences of identity, trauma, drugs, family, friendships, love, and sex. The show is the second most watched show in HBO history, behind Game of Thrones, and it was just renewed for a 3rd season.   My So-Called Life is available on Hulu, Euphoria is on HBO Max.   Hot Topics: 1.) What is "America Online"? 2.) The Alicia Silverstone connection 3.) Unfair comparisons: prestige TV vs. network television, style vs. realism, dyeing your hair vs. doing fentanyl 4.) Overuse of music and the ensuing emotional manipulation 5.) Antiheros, moral ambiguity, and unreliable narrators 6.) Voiceovers and getting teenage dialogue right 7.) Focusing on the MSCL episode "Other People's Mothers": drugs, teenagers, and traditional vs. permissive parenting styles 8.) Very Special Episodes(TM) 9.) The crazy Rainbow-style fashion aesthetic of Euphoria 10.) Friend crushes and moral stances  https://en.wikipedia.org/wiki/My_So-Called_Life   https://en.wikipedia.org/wiki/Euphoria_(American_TV_series)

We have our FIRST guest! Welcome to PJ our dear friend, junior high AND high school classmate, and renowned My So-Called Life expert, Logan Cooper. Logan comes to our discussion with Media Studies Professor-level incisiveness about this beloved cult classic and mid-90s time capsule. We throw fisticuffs over Rayanne Graff, discuss our own respective Catalanos (and Krakows!), and Logan explains why Sharon Cherski is the colorful backpack–no, knapsack–of the show, metaphorically. We also tell the epic tale of the night we all went out to a Chippendale's show senior year. Now if you'll excuse us, we're gonna go smoke some DOOBIES. We'll see you in 2022! You can get EARLY ACCESS to our eps (AND PJ MERCH!) by subscribing to us on Patreon: https://patreon.com/popjunction  Follow us on IG at @popjunctionpod An Oral History of MSCL: https://www.elle.com/culture/movies-tv/a40594/my-so-called-life-cast-interviews/

MSCL UP. Remember the brand and let me introduce you to Maddy Richie. A proud Gamilaroi woman, she's an entrepreneur, a registered nurse, artist, fiancé and mother. Maddy and her partner Asher created MSCL UP with a vision of combing fitness, health, education and a hope of giving back to the community. Let me tell you, they're certainly doing that! Maddy's journey is a great reminder that even when you think you can't, you can.

Ray Dalio dice que posee algo de Bitcoin China intenta regular la minería de Bitcoin. Énfasis en “Intenta” Marathon y Compute North instalarán 73.000 nuevos mineros en TEXAS Coinbase contrata ex ejecutivo de Goldman Sachs como director de política Pérdidas registradas en Bitcoin hacen historia https://decrypt.co/71798/ray-dalio-says-he-owns-some-bitcoin https://twitter.com/CoinDesk/status/1396826764719050755 https://www.theblockcrypto.com/post/105814/china-bitcoin-miners-brace-regulatory-uncertainty https://twitter.com/jiangzhuoer/status/1396754235170164737?s=21 https://www.criptonoticias.com/mineria/huobi-cierra-servicios-mineria-bitcoin-medidas-gobierno-chino/ https://bitcoinmagazine.com/business/compute-north-hosting-marathon-bitcoin-miners https://www.theblockcrypto.com/linked/105853/coinbase-former-goldman-sachs-faryar-shirzad-chief-policy-officer https://insights.glassnode.com/the-week-on-chain-week-21-2021/ https://studio.glassnode.com/metrics?a=BTC&category=&chartStyle=line&contractExpiration=1640908800&ema=0&m=indicators.RealizedLoss&mAvg=0&mMedian=0&mScl=lin&resolution=24h A las dos y media de la tarde, hora Venezuela, el precio de Bitcoin es de 38.085 dólares con una variación al alza en 24 horas de 15,71 % El porcentaje de señalización para la activación de Taproot en el segundo Ciclo de ajuste de dificultad es de 85.99% y no podrá ser señalizado en este período. El Hashrate es de 148.160 Sigue a Satoshi en Venezuela en Redes Sociales: Twitter: https://twitter.com/satoshienvzla Instagram: https://instagram.com/satoshienvzla Únete a nuestro canal de Telegram: https://t.me/satoshien Haz una donación a Satoshi en Venezuela: https://satoshienvenezuela.com/contacto/

This week on Speaking Highly, Jon schools Indy on the mid 90's TV show MY SO CALLED LIFE and lectures him on the shows amazing writing and talented cast. Then, straight outta Warrenville – Jon sits down (virtually) with Senta Moses Mikan. Not only was Senta in The Blues Brothers, DC Cab and Home Alone, she also had a pretty fantastic three episode arc as Delia Fisher on MSCL. We get into authenticity, auditioning and painting. Senta's the best and this episode is like… pretty great or whatever. So… like… enjoy. Geez. ---Senta's Etsy shop: https://www.etsy.com/shop/CurlyGirlWatercolorsFollow Senta on Twitter: https://www.twitter.com/SentaMosesMikan---Check out Jon's latest comedy album, COMPROMISED MATURITY: https://800pgr.lnk.to/HuckWEFollow Jon on social media:Instagram | https://www.instagram.com/jon_huckTwitter | https://www.twitter.com/jonhuckJon's website | https://www.jonhuck.me/---Follow Producer Indy on Instagram: https://www.instagram.com/indyfawcett---Produced by https://www.chobo.co—Recorded 2021-01-16---#SHJH #MySoCalledLife #SentaMosesMikanSupport this podcast at — https://redcircle.com/speaking-highly-with-jon-huck/donations

A lot of shows have been made through the decades about teenagers but none captured the joy, the awkwardness of growth, the struggles, and the internal reflections like mid-90s offering “My So Called Life”. Perhaps we are dating ourselves but, we see so many parallels here between coaching and the teenagers of both MSCL's fictional world and the real world. As coaches, we experience the peaks of joy when our work with clients and partners leads to success; even more so when a chance encounter in the hallway with a teacher that leads to a budding connection. Our identity and how we relate to others is of such crucial importance, so join the Guild as they share the dramas and internal monologues that make up “My So- Called Coaching Life”.

This is the Arete Coach Podcast where we explore the art and science of executive coaching with host Severin Sorensen. Our guest is Divya Jegasundaram, ACC, MSCL, CLC. Divya's path to executive coaching came the banking sector. She transitioned to life coaching, organizational development coaching, and executive coaching. She is the co-author of the best selling series, "Coach Wisdom." This interview was recorded on November 24, 2020. Copyright © 2020 by Arete Coach™ LLC. All rights reserved.

SUPPORT THE SHOW: LEDN offers Bitcoin backed loans – Sign up and get $50 free https://bit.ly/34FeT2f Get Wasabi wallet and enjoy your Bitcoin privacy https://wasabiwallet.io/ Buy a Cobo Vault to secure your Bitcoin! https://bit.ly/2GgMFlH Cobo Vault Tutorial https://www.youtube.com/watch?v=JnRjvZKulrA Crypto Cloaks: Get the BEST Bitcoin swag out there https://www.cryptocloaks.com/shop/ If you value my work and would like to send me a tip, they are always appreciated! LIGHTNING tips: https://tippin.me/@BTCsessions Join my Telegram channel! https://t.me/btc_sessions SHOW RESOURCES: Bitcoin breaks $11K https://www.coindesk.com/bitcoin-tops-11k-for-first-time-in-almost-3-weeks Square invests $50M or 1% of assets into Bitcoin https://decrypt.co/44319/square-invests-50-million-in-bitcoin Publicly traded companies with Bitcoin on their balance sheets https://bitcointreasuries.org/ Bitcoin hashrate and price charts on Glassnode https://studio.glassnode.com/metrics?a=BTC&category=&m=mining.HashRateMean&mScl=lin&pScl=lin&resolution=1h Riot Blockchain aims to quadruple hash power https://www.coindesk.com/riot-buys-antminers-bitmain BitMEX coins labelled “high risk” by Chainalysis https://www.forbes.com/sites/billybambrough/2020/10/07/high-risk-warning-bitcoin-exchange-bitmex-is-in-even-worse-trouble-than-thought/#3ca4afe314b3 LND vulnerability disclosed, upgrade to 0.11 and higher https://decrypt.co/44439/a-version-of-bitcoins-lightning-has-unknown-vulnerability Check out my interview with Anders: https://www.youtube.com/watch?v=ivgFgq2No4g --- Support this podcast: https://anchor.fm/btcsessions/support

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.19.257485v1?rss=1 Authors: Tatikonda, R. R., Anishkin, A., Sukharev, S. I., Vanegas, J. M. Abstract: Membrane tension perceived by mechanosensitive (MS) proteins mediates cellular responses to mechanical stimuli and osmotic stresses, and it also guides multiple biological functions including cardiovascular control and development. In bacteria, MS channels function as tension-activated pores limiting excessive turgor pressure, with MscL (MS channel of large conductance) acting as an emergency release valve preventing cell lysis. Previous attempts to simulate gating transitions in MscL by either directly applying steering forces to the protein or by increasing the whole system tension were not fully successful and often disrupted the integrity of the system. We present a novel locally distributed tension molecular dynamics (LDT-MD) simulation method that allows application of forces continuously distributed among lipids surrounding the channel using a specially constructed collective variable. We report reproducible and reversible transitions of MscL to the open state with measured parameters of lateral expansion and conductivity that exactly satisfy experimental values. The LDT-MD method enables exploration of the MscL gating process with different pulling velocities and variable tension asymmetry between the inner and outer membrane leaflets. We use LDT-MD in combination with well-tempered metadynamics to reconstruct the tension-dependent free energy landscape for the opening transition in MscL. Copy rights belong to original authors. Visit the link for more info

Join us (socially distance style) as we answer questions from our “ask us anything about #MSCL” poll, read some reviews and shout out the amazing people that have been leaving […]

Our first summer school mini is now available! Today we cover the pilot episode of My So Called Life. While Alex is a MSCL first timer, CJ has been copying […]

Like an angst-seeking missile, Angela Chase has gone from trailing after living phantom Jordan Catalano to actual phantom Nicky Driscoll in this Halloweeniest of episodes. We promise this is not a backdoor pilot for Chelsea’s spinoff MSCL podcast. Probably. Show: MY SO-CALLED LIFE “Halloween,” Season 1, Episode 9 Air Date: October 27, 1994 Find it: on Amazon Prime Video ($0.99 to buy episode) Snacks: Handmade: donuts from Blue Star Donuts Spooky: Brach’s Classic Candy Corn, M&Ms White Chocolate Candy Corn, Kraft Jet-Puffed Candy Corn Mallows Sweet: M&Ms Creepy Cocoa Crisp Further Reading: My So-Called Life: “Halloween” | The AV Club What I Learned From Re-Watching My-So Called Life as an Adult | The Atlantic ************************ Don’t forget about Click-Or Treat! Leave us an iTunes review or post about us on social media, to get a H&L sticker or coaster, and be entered to win our Very Special Prize package! Click here for all the deets!

*Minor Spoilers for MSCL in this episode!* Hello! We have an extra episode for you this week where we talk with our listener Kate Vlasek — who is also a My So-Called Life super-fan — all about her thoughts on The Zit! Kate tells us about her deep love for the show and this episode in particular, Kristin reveals that she has had a recent dream about Jordan Catalano, Joanna tells us about singing showtunes in high school, and we even dig into to a comparison between Lindsay Weir and Angela Chase! Follow The Boiler Room @boilerroomcast Follow Joanna Robinson @jowrotethis Follow Kristin Russo @kristinnoeline Follow Kate @possiblyevenme Check out Kate's Babysitters Club Podcast, Generation BSC  @generationbsc  https://podcasts.apple.com/us/podcast/generation-bsc/id1481054464 Theme Song by Chris Farren Logo by Carra Sykes Edited by Lauren Klein Best Use of Flannel jingle by Lauren Klein

You better work it, girl! It's time for a fashion show and it's for a great cause, you guys, so please give your time and sense of style to these two episodes that feature a whole lot of things to talk about besides fashion--although we do spend a fair amount of time discussing flip flops. Episodes:  My So-Called Life 1x05 "The Zit" [Hulu] vs. The O.C. 1x01 "Pilot" [Hulu] Get social with us @tvwinnerpod on all the stuff. Email at tvwinnerpod@gmail.com. Find Beth @yourbeth_friend. Find Hannah @nobriggity. Our theme music is by @ariellajoymusic. Rate and review us on Apple Podcasts.

A discussion of the Cranberries' "Ridiculous Thoughts" gets us talking about the bands we loved in private, our ongoing feelings for My So-Called Life, and the preponderance of tank tops in 90s rock videos. Plus, Joe Reid is our special guest! Our intro is by Andrew Byrne, and our outro is a crucial TV theme from the 90s. Want to request a song, buy a birthday chart reading, or just say hello? Email us (talkaboutsongs@gmail.com), tweet us (@TalkSongs), or Facebook us (facebook.com/mastas.podcast). Want to get bonus content and vote in ranking episodes? Become a patron at patreon.com/mastas. Special Guest: Joe Reid.

1. PLANET OF DRUMS "Bodhran" (Avex Trax, 1996) 2. UNIT MOEBIUS "Dolfinarium" (Interr-Ference Communications, 1994) 3. CHEAP & DEEP PRODUCTIONS "Darkroom Beats" (Cheap & Deep, 2009) 4. MORITZ VON OSWALD TRIO "Pattern 1" (Honest Jon's, 2009) 5. PANGAEA "You Know What's Up" (Hadal, 2018) 6. FOREST DRIVE WEST "Reshape" (Neighbourhood, 2018) 7. ROMAN PONCET "Thick Vegetation" (Figure, 2018) 8. DJ QU "Picazon" (Strength Music Recordings, 2018) 9. LORD OF THE ISLES "To Here" (DFSANT, 2017) 10. BLACKSTONE "Samba Oscura" (R&S, 2018) 11. DOLO PERCUSSION "Dolo 9" (The Trilogy Tapes, 2018) 12. LURKA "Battery" (Timedance, 2018) 13. VELODROME "Capataz - Secret Mixes/Fixes Edit" (Animalized / Secret Mixes/Fixes, 1988/2005) 14. LA-4A "Prollum" (Delft, 2018) 15. GRAZE "Hook" (New Kanada, 2016) 16. *unreleased* 17. D MAN "B1" (Workshop, 2018) 18. CHEKOV "Stasis 113" (Timedance, 2018) 19. BUTTECHNO "LOZH" (Zodiac 44, 2018) 20. CROCKER "Tower" (NTA, 1994) 21. SHADOWAX "A & B - Buttechno Remix" (Rassvet, 2018) 22. DA SAMPLA "Frictional Beat #6 - KMFH 808 Dub" (Wild Oats, 2012) 23. BASIC SOUL UNIT "Descendant" (Dolly, 2018) 24. STEPHEN LOPKIN "Fridays At Pure" (M>O>S Recordings, 2018) 25. DEVICE CONTROL "Symmetry Obsession" (Double Standards, 2018) 26. L/F/D/M "Silver Grain - D-56M Poverty Remix" (Midnight Shift Records, 2018) 27. SLAM "Positive Education - Antigone Remix" (Soma Quality Recordings, 2017) 28. ROBERT S "303 Acidos" (Planet Rhythm, 2018) 29. TIN MAN "Bass Tunnel" (Global A Records, 2005) 30. BILL CONVERSE "Station Life" (Dark Entries, 2018) 31. JOHN TEJADA & JUSTIN MAXWELL "Thundaar The Modularian" (Palette Recordings, 2009) 32. FELIX K "MSCL" (Nullpunkt, 2018) 33. PARANOID LONDON w/ BUBBLES BUBBLESYNSKI "Beats & Bubbles" (Paranoid London Records, 2018) 34. CASSIUS SELECT "Yut" (Hypercolour, 2018) 35. OISEL "SAT04" (Warm Up Recordings, 2018) 36. AUTOCREATION "Justice Loop" (Inter-Modo, 1994) 37. DANIEL AVERY "Diminuendo - Patrick Russell Remix" (Phantasy Sound, 2018) 38. IRAZU "Enduring Form - Pessimist Remix" (Stale, 2018) 39. LOOP LF "Drive 22" (Well Street Records, 2017) 40. BENNY LIBERG / JOHANNES WIKSTROM "Semicircular EP - B1" (Maracas, 1999) 41. PESSIMIST "Inner Circle" (Osiris Music UK, 2017) 42. CHRISTIAN WUNSCH "Bleeding Walls - Orphx Remix" (Tsunami Records, 2018) 43. WILLIAM PAYEUX "S - B1" (Payeux, 1997) 44. VIL "Metafora" (Hayes, 2018) 45. REEKO "Methodical" (Warm Up Recordings, 2006) 46. DJ OVERDOSE "Wires Smoking" (L.I.E.S., 2018) 47. BLONDES "Quality Of Life - Struction Remix" (R&S, 2018) 48. BRENECKI "Motivate Me" (Bandcamp, 2018) 49. YAK "Lucid Nightmare" (3024, 2018) 50. JAMES RUSKIN "Correction Centre - B1" (Blueprint, 2001) 51. COCKTAIL PARTY EFFECT "This Is Science" (Transfigured Time, 2018) 52. HODGE & RANDOMER "If I Could Stop - Alden Tyrell & Serge Remix" (Clone Basement Series, 2017) 53. /DL/MS "100 Beats" (Frustrated Funk, 2018) 54. SOLID BLAKE "Warp Room" (Seilscheibenpfeiler, 2018) 55. EXTERMINADOR "Guaraci" (Cultivated Electronics, 2018) 56. NX1 "025 - The Exaltics Remix" (Nexe Records, 2017) 57. JENSEN INTERCEPTOR "Haze" (Lone Romantic, 2018) 58. JK FLESH "Exit Stance" (Downwards, 2017) 59. LAG "Rutra" (Elements (RBK), 2018) 60. TUNNEL "Talker Remix - *forthcoming*, 2019" 61. SHLOMI ABER "Installer" (Be As One Imprint, 2018) 62. STAVE & GREBENSTEIN "Alfa" (Standards & Practices, 2018) 63. EBB "Sun Drips" (Fox & Hound Recordings, 2018)

Brian speaks with MSCL fanatic Yvette Quintanar. It's her first podcast and boy was she nervous! Will Tino show up on our podcast? You'll have to like listen to like, find out or something, in my humble opinion. Podcast also features Sergio Quintanar and James Mastro.

This week we're discussing shows with narrators -- and that one episode where they change it up. Does it work? Do we care what Brian Krakow thinks? Is it hard to be a woman in any workplace? Tune in to find out!! Episodes:  My So-Called Life 1x11: "Life of Brian" vs. Scrubs 4x05: "Her Story" Get social with us @tvwinnerpod on all the things and at @nobriggity (It's Hannah!) and @yourbeth_friend (It's Beth! Duh!)

Step 55 - It's time for another My So-Called Life Rewatch! Watch this MSCL episode for free on ABC Go and then come back and listen to us (Brooke and Nikki) break it down with LOTS of tangents along the way! Special thanks to Steven Palomino for our theme song!

Step 21 - My So-Called Slumber Party - This week, we talk sleepovers and slumber parties in the 80’s and 90’s. I know you may have been expecting MSCL - but we decided to take a little break (we’ll get back to that soon). Meanwhile sit back, relax, and listen to Nikki & Brooke as they talk about all the things we miss (and some of the things we don’t *ahem* Ouija Boards *ahem*)

We did it! We finally finished watching all 19 episodes of My So-Called Life, our favorite tv show ever! I'm not sure if we actually talked about it during this recording, but we definitely watched it! Thanks for hanging in with us, there will be much more MSCL talk, don't ya worry! We love you!

We did it! We finally finished watching all 19 episodes of My So-Called Life, our favorite tv show ever! I'm not sure if we actually talked about it during this recording, but we definitely watched it! Thanks for hanging in with us, there will be much more MSCL talk, don't ya worry! We love you!

We’re back! After a little under a year the Go Now Go Gang has regrouped and FINALLY brings you a brand new episode! In Betrayal, Rayanne sleeps with Jordan, much to the dismay of Brian, Chursky, and Angela. Narrated by Danielle, Weekend shows us why Patty doesn’t drink, and Rayanne and Angela’s feud comes to a head…and handcuffs! Don’t miss all the wine-tastic-ness, hit download!! follow us on twitter @gonowgo1 @totallybitchin on instagram and check out the totally bitchin podcast feed on all podcatchers, where you can find our new shows, Inner Demons and Bad Luck!! *** “Were you happy?” What’s your fav tearjerker scene from MSCL?

We’re back! After a little under a year the Go Now Go Gang has regrouped and FINALLY brings you a brand new episode! In Betrayal, Rayanne sleeps with Jordan, much to the dismay of Brian, Chursky, and Angela. Narrated by Danielle, Weekend shows us why Patty doesn’t drink, and Rayanne and Angela’s feud comes to a head…and handcuffs! Don’t miss all the wine-tastic-ness, hit download!! follow us on twitter @gonowgo1 @totallybitchin on instagram and check out the totally bitchin podcast feed on all podcatchers, where you can find our new shows, Inner Demons and Bad Luck!! *** “Were you happy?” What’s your fav tearjerker scene from MSCL?

We’re back! After a somewhat-longer-than-expected hiatus, we toss out a somewhat-longer-than-expected episode, because “Life of Brian” is just that interesting. It’s the first MSCL to give the v/o to someone other than Angela, and it turns out the things going on in Brian’s head are just as weird, if not weirder. Plus, new diary entries […]

Why are you like this? Like what? Like how you are? Hey Gang! We are so happy to be back and with a double episode to boot! Happy 2016!! Miranda, Jamie & Shannon have reconvened at TotesBee Studios to talk about Episodes 13 AND 14, “Self-Esteem” & “Pressure”!!!! Spread the word! and give us recommendations for MSCL related movies! #GoNowGo twitter.com/totallybitchinn facebook.com/totallybeachin instagram.com/totallybitchin #spongefingers !! #hatfield #hashfield…. wait #gofield #angelsintheoutfieldfield #howdidyoudie

Why are you like this? Like what? Like how you are? Hey Gang! We are so happy to be back and with a double episode to boot! Happy 2016!! Miranda, Jamie & Shannon have reconvened at TotesBee Studios to talk about Episodes 13 AND 14, “Self-Esteem” & “Pressure”!!!! Spread the word! and give us recommendations for MSCL related movies! #GoNowGo twitter.com/totallybitchinn facebook.com/totallybeachin instagram.com/totallybitchin #spongefingers !! #hatfield #hashfield…. wait #gofield #angelsintheoutfieldfield #howdidyoudie

My MSCL two-parter concludes with an extra-sized celebration through conversations with longtime fans of the show. Join me, Sarah Bunting (of TWoP and Previously.tv fame), Cory, Mark, Andrea, and chelle as we talk about MSCL, its impact on our lives, our history as fans, and the show's legacy twenty years later. Show notes and pictures are available at http://popcultureaffidavit.com, which is also where you can see regular weekly blog entries about the randomness that is pop culture. Feedback can be addressed to popcultureaffidavit@gmail.com

My MSCL two-parter concludes with an extra-sized celebration through conversations with longtime fans of the show. Join me, Sarah Bunting (of TWoP and Previously.tv fame), Cory, Mark, Andrea, and chelle as we talk about MSCL, its impact on our lives, our history as fans, and the show's legacy twenty years later. Show notes and pictures are available at http://popcultureaffidavit.com, which is also where you can see regular weekly blog entries about the randomness that is pop culture. Feedback can be addressed to popcultureaffidavit@gmail.com

My MSCL two-parter concludes with an extra-sized celebration through conversations with longtime fans of the show. Join me, Sarah Bunting (of TWoP and Previously.tv fame), Cory, Mark, Andrea, and chelle as we talk about MSCL, its impact on our lives, our history as fans, and the show’s legacy twenty years [...]

In this study, cryo-electron microscopy (cryo-EM) and single particle reconstruction were used as a main technique to investigate the involvement of bacterial ribosomes in two crucial cellular processes: the regulation of gene expression and the biogenesis of membrane proteins. Whereas most nascent chains are thought to transit passively through the ribosomal exit tunnel during translation, a number of regulatory peptide sequences, such as TnaC and SecM, have been proposed to specifically interact with tunnel components, causing the ribosome to stall which in turn regulates the expression of downstream gene products. In the first part of this study, a 5.8 Å resolution cryo-EM reconstruction of an Escherichia coli 70S ribosome stalled during translation of the TnaC leader peptide could be determined. The high quality of the map allowed the visualization of the TnaC nascent chain within the exit tunnel of the ribosome, making contacts with ribosomal components at distinct sites. At the peptidyl transferase center (PTC), the universally conserved nucleotides A2602 and U2585 adopt conformations that are incompatible with co-habitation of the termination release factors. Moreover, a model could be proposed where interactions within the tunnel are relayed back to the PTC, leading to its inactivation. In addition, a foundation for the elucidation of the SecM-stalling mechanism could also be established. The membrane protein insertase YidC is the prokaryotic member of the conserved YidC/Oxa1/Alb3 protein family. It assists in the assembly and folding of membrane proteins in conjunction with the Sec translocase as well as on its own. E. coli YidC is a hexaspan protein with a large, non-conserved periplasmic domain between the first and second transmembrane (TM) segment. In contrast, YidC2 from the Gram-positive bacterium Streptococcus mutans contains five TM segments and an extended C-terminal region akin to the C-terminal ribosome binding domain of the mitochondrial YidC homolog Oxa1. In the second part of this study, programmed 70S ribosomes carrying the YidC-specific nascent chain MscL could be generated, and visualized in a preliminary low-resolution cryo-EM structure in complex with E. coli YidC. Furthermore, purified S. mutans YidC2 was reconstituted into proteoliposomes and the formation of a ribosome-YidC2-proteoliposome complex could be demonstrated. Thus, the foundations have been laid for the visualization of YidC2 in the membrane environment. Improvement of the preliminary RNC-YidC structure together with determination of an RNC-YidC2 complex are expected to provide insights into the molecular mechanism of YidC mediated membrane protein biogenesis.