Podcasts about retinols

Check out Dr. Mina's top picks for skin care here. In this week's recap episode, Dr. Mary Alice Mina discusses the effects of menopause on skin health, drawing insights from her podcast with Dr. Brenda Dintiman. The episode covers the physiological changes women experience during menopause, particularly the decline in estrogen and its impact on skin, hair, and overall health. Dr. Mina emphasizes the importance of understanding these changes and offers practical advice for managing skin health during this transitional phase of life. Key Takeaways: - Menopause is a natural phase that affects all women. - Collagen levels drop significantly during menopause. - Skin becomes drier and more sensitive due to hormonal changes. - Hormonal acne can reappear in menopausal women. - Hair thinning is a common issue during menopause. - Sun damage effects become more pronounced in later decades. - Moisturizing is crucial for maintaining skin health. - Retinols and retinoids can help improve skin condition. - Lifestyle choices significantly impact skin health during menopause. - Consulting a dermatologist is essential for personalized care. Follow Dr. Mina here:-  https://instagram.com/drminaskin https://www.facebook.com/drminaskin https://www.youtube.com/@drminaskin https://www.linkedin.com/in/drminaskin/ For more great skin care tips, subscribe to The Skin Real Podcast or visit www.theskinreal.com Baucom & Mina Derm Surgery, LLC Website- https://www.atlantadermsurgery.com/ Email - scheduling@atlantadermsurgery.com Contact - (404) 844-0496 Instagram - https://www.instagram.com/baucomminamd/ Thanks for listening! The content of this podcast is for entertainment, educational, and informational purposes and does not constitute formal medical advice.  

Check out Dr. Mina's top picks for skin care here. In this episode, Dr. Mina discusses the safety of Bakuchiol as an alternative to retinol and retinoids during pregnancy, emphasizing the lack of data supporting its safety. She highlights the importance of retinols and retinoids in skincare, detailing their benefits, including increased cell turnover and treatment for hyperpigmentation. Dr. Mina also addresses pregnancy considerations, recommending alternatives for pregnant individuals. She provides practical tips for incorporating retinoids into a skincare routine, stressing the importance of patience in seeing results. Tune in for key insights from the latest podcast episode featuring Dr. Caroline Chang. Key Takeaways: - Bakuchiol lacks sufficient data for safety during pregnancy. - Retinols and retinoids are essential for skin health. - Retinoids increase cell turnover and collagen production. - Pregnant individuals should avoid retinoids due to potential risks. - Moisturizing after retinoid application is crucial. - Peeling and irritation are normal when starting retinoids. - Results from retinoids take time; patience is key. - Adapalene is a gentler alternative for sensitive skin. - Using retinoids at night maximizes effectiveness. - Retinoids can significantly improve skin vitality and health. In This Episode: (03:15) The Importance of Retinols and Retinoids (07:02) Benefits of Retinoids for Skin Health (09:14) Pregnancy Considerations with Retinoids (11:12) Incorporating Retinoids into Your Skincare Routine (14 :05) Patience is Key with Retinoid Results Follow Dr. Mina here:-  https://instagram.com/drminaskin https://www.facebook.com/drminaskin https://www.youtube.com/@drminaskin https://www.linkedin.com/in/drminaskin/ For more great skin care tips, subscribe to The Skin Real Podcast or visit www.theskinreal.com Baucom & Mina Derm Surgery, LLC Website- https://www.atlantadermsurgery.com/ Email - scheduling@atlantadermsurgery.com Contact - (404) 844-0496 Instagram - https://www.instagram.com/baucomminamd/ Thanks for listening! The content of this podcast is for entertainment, educational, and informational purposes and does not constitute formal medical advice.

Dr Rina discusses alternatives to retinol and retinoids to help tackle acne, signs of skin aging and pigmentary change.

Skin Expert: My 3 MUST HAVE Skin Products | Vitamin C, Hyaluronic Acid & Retinols. Today we brought the lovely Stacey, The Smart Skin Expert onto the show to talk all things skincare and skin treatments. Stacey has built her business on creating beautiful foundations in her clients skin, creating solid foundations for other treatments such as injectables. Learn how you can use at-home skin products to create a better, smoother canvas for your injector, creating optimal results.  Watch on Youtube : https://youtu.be/lgxPhAdZJYs Follow Stacey and her company Smart Skin Expert: Instagram - https://www.instagram.com/smartskinexpert Website - https://www.smartskinexpert.com/ Join Faces Consent for FREE: https://www.facesconsent.com  Follow your host: https://www.instagram.com/faceitpod  https://www.instagram.com/jess_messenger

DISCLAMER >>>>>>    The Ditch Lab Coat podcast serves solely for general informational purposes and does not serve as a substitute for professional medical services such as medicine or nursing. It does not establish a doctor/patient relationship, and the use of information from the podcast or linked materials is at the user's own risk. The content does not aim to replace professional medical advice, diagnosis, or treatment, and users should promptly seek guidance from healthcare professionals for any medical conditions.                                                  >>>>>> The expressed opinions belong solely to the hosts and guests, and they do not necessarily reflect the views or opinions of the Hospitals, Clinics, Universities, or any other organization associated with the host or guests.                                                                                  Disclosures: Ditch The Lab Coat podcast is produced by (Podkind.co) and is independent of Dr. Bonta's teaching and research roles at McMaster University, Temerty Faculty of Medicine and Queens University. Dr. Renita Ahluwalia, a respected authority in dermatology, stands at the forefront of skincare with a clear message: protection is paramount. She asserts with confidence that the secret to youthful skin, above all other remedies and regimens, lies in the consistent use of sunscreen. According to Dr. Ahluwalia, this is not merely a summer routine but a year-round shield against the aging effects of the sun.Her expertise extends to understanding the unique needs of diverse skin types, highlighting that those with richer pigmentation benefit from sunscreens enriched with visible light filters like iron oxide. These filters are not just cosmetic enhancements but a critical line of defense in reducing the exacerbation of reds, browns, and fine lines that disproportionately affect pigmented skin.Dr. Ahluwalia is equally passionate about the scientifically backed benefits of retinol and its derivatives. While commonly known for treating acne, she educates on retinol's potent anti-aging and pigmentation properties. Her advocacy for these two key skincare elements positions her as a trusted guide for patients seeking to preserve their skin's health and vitality. In a world crowded with miracle cures and fleeting trends, Dr. Renita Ahluwalia remains a steadfast champion of evidence-based skincare.Welcome back to another fascinating episode of "Ditch the Labcoat," where we peel away the mystique of modern medicine and explore practical health topics with the experts. I'm your host, Dr. Mark Bonta, and with me today is the esteemed Dr. Renita Ahluwalia, a renowned dermatologist and founder of the Canadian Dermatology Center.In today's episode, we're smoothing out the wrinkles of truth behind anti-aging treatments. We'll delve deep into the world of Botox, fillers, and the lifestyle factors that contribute to our skin's health. Dr. Ahluwalia will share her wealth of knowledge on maintaining a wellness lifestyle for better aging and decipher the complex landscape of hair loss treatments, from PRP to hair transplants. We'll also clear up some common misconceptions about acne and its treatments, debunking myths about chocolate and diet while reinforcing the importance of establishing a proper skincare routine. Expect practical tips on preventative measures for acne scarring and insights on how injectable treatments, when administered correctly, can achieve subtle, natural enhancements.Amidst these discussions, Dr. Ahluwalia urges the importance of wearing sunscreen to protect against sun exposure and highlights the impressive benefits of retinol for skin health. And for a bit of fun, we play with the idea of animal hair transplants and see where that takes us.Join us as we uncover the layers of skin and hair care, discuss ancient Greek skincare practices that still influence us today, and focus on the vital role of mental health and stress management in treating skin conditions. By the end of our conversation, I'm confident both you and I will have a treasure trove of insights to bring into our personal and professional lives.So sit back, lather on that sunscreen, and get ready to challenge some age-old beliefs while embracing scientifically-backed skincare strategies. Don't forget to rate and review us on your favorite streaming platform, and to always stay updated, visit Labcoat FM for more info. Let's dive right in!

This Christmas we've heard of girls as young as eight asking for skincare products as presents, including Retinols, Acids and other stuff we don't understand. So to help us figure it out, we asked Dr Laura to chat to us about if these products are necessary or if we're wasting our money. Spoiler alert... yes we are. Dr Laura breaks down what the products do, which are helpful for acne, and which are actually harmful in the long run. Tammy, who is the WORST when it comes to being influenced to buy stuff online has a word with herself, and alls well that ends well.Send your emails to podcast@shona.ie, we'd love to hear from you.

Is your skin changing in perimenopause and menopause? You're not alone. Andrea Donsky, nutritionist, menopause researcher, and educator, talks with Susan Campbell,  the founder and CEO of Phosis, a skincare company dedicated to nourishing women's skin during perimenopause and menopause. Susan provides many tips for better skin in perimenopause and menopause.Morphus Omega 3-T https://bit.ly/3rpSFjC0:23 Introductions and why Susan decided to found a skincare company for women in perimenopause and menopause.3:50 Skin changes in perimenopause and menopause.4:36 Nourishing our skin from the inside out.12:59 The ingredients to look for in perimenopause and menopause and ingredients for condition-specific skincare issues. 21:18 Skincare ingredients to always avoid.29:09 News about changes that are finally occurring in the labeling requirements for skincare.33:17 The importance of barrier function and avoiding over-cleansing.38:34 How to use different types of skincare products.44:28 Other areas of your body that need care, too, like your neck, chest, and hands.47:32 Retinols and their alternatives, specifically bakuchiol.49:49 How to exfoliate properly for dull skin.55:15 Do It Yourself facial tips.58:26 Susan's beekeeping hobby.1:03:02 Final thoughts on hydration and stress management.Morphus Omega 3-T https://bit.ly/3rpSFjCIf you'd like to be a guest on our podcast, please email questions@wearemorphus.comSusan's Skincare Company is launching in Spring 2024. Sign up for her list at  Phosis Skincare https://www.phosis.com/Watch the interview on YouTube https://youtu.be/LKWamR4AG2IOther videos mentioned in this podcast:Disease Prevention with the Right Foods- Part 1 https://youtu.be/HshqoTgQ4bM?si=O6otyuYO76feaRukPart 1: Hormone Disrupting Chemicals to Avoid in Menopause https://youtu.be/OG_r4S8ngy8?si=ZbzJW6n_0jr4HpS7 Part 2: Hormone Disrupting Chemicals to Avoid in Menopause https://youtu.be/WN99e-FffZc?si=k-2sahYiy6pgIeOqPart 3: Hormone Disrupting Chemicals to Avoid For Women's Health in Menopause https://youtu.be/kBfVO22R7j4?si=Kk9j8phunDkxpjMc======

In this episode, we brought in a special guest, Dr. Mamina Turegano, a highly accomplished dermatologist, internist, and dermatopathologist who sheds light on a range of fascinating topics.  Throughout our conversation, we cover a multitude of topics relating to skincare, including retinols and retinoids, pore size, the power of vitamin C, and the importance of sunscreen. Dr. Mamina also provides valuable insights on treating acne scars, the benefits of red light therapy, and effective solutions for stretch marks and hair loss. Whether you're a skincare enthusiast, seeking expert advice, or simply curious about these topics, this episode is packed with valuable information. Tune in and join the Health Babes as they explore the world of beauty and wellness from a holistic standpoint.   TOPICS:  Botox (01:29) Retinols & Retinoids (10:37) Pore size (14:47) Vitamin C (17:55) Sunscreen (20:20) Treating Acne Scars (26:53) Red Light Therapy (34:12) Stretch Marks (36:00) Hair Loss (39:44)   More from Dr. Mamina Turegano  

Retinols and retinoids are mighty vitamin A creams that really pack a punch. These skin creams are a 'must-have' for people looking to help treat acne, brighten their skin, and get a fresh skin glow. It's been my one and only night time skin product for over 10 years now. Studies have shown that retinols (over the counter) and retinoids (prescription only) help improve cell turnover, open up clogged pores, and increase collagen formation in the skin. Sound too good to be true? Thankfully, it's not.  Listen in as I discuss one of my favorite topical creams on this week's episode.

This episode of the Biohacking Beauty podcast is the biohackers guide to five mistakes that we are making with our skin care routine. Amitay Eshel, co-founder and CEO of Young Goose, talks about how to properly apply hyaluronic acid and retinols. He also discusses why we shouldn't do serum cycling, apply chemical sun blocks and skip cleansing.0:00 - Intro2:51 - Why Hyaluronic Acid shouldn't be applied on dry skin?4:29 - How we should properly apply Retinols? 6:00 - Why it is recommended to use Retinols?6:57 - Why serum cycling is not advisable?9:14 - Importance of applying sun block and why we should avoid chemical sun blocks?12:50 - Why we should not skip cleansing?

Rachael Pontillo is a functional nutrition practitioner and a licensed aesthetician, herbalist and skincare formulator. She teaches women how to make their own products without synthetic ingredients that do more harm than good. Anti-aging is hijacking young women's lives as they strive for an unattainable beauty standard that cannot be bought. Rachael teaches you how to age gracefully by doing less and allowing your skin to go through its natural cycles.    When buying any product it is important to identify harmful ingredients masquerading as Vitamins because they just do not offer the same nutrients as a natural source would. Many of these synthetic compounds have not been around long enough to even know what the long term effects are.    Rachael teaches you what to look for and what to avoid. Ultimately though, she encourages you to ask yourself, why do you need any product at all? If you are spending money, time and energy using products that are harmful and really cannot stop the aging product, what is the purpose? By focusing on a healthy lifestyle, instead of relying on products,  you can boost your skin's natural ability to heal itself without expensive or harmful intervention and age gracefully.   Takeaways: [4:30] Anti-aging is an unattainable marketing message and it's harmful to younger woman [6:45] In-Vitro research does not necessarily translate to regular usage of a product on humans [8:30] Your skin takes in nutrients from the food you eat not the products you put on it [11:00] Products using ascorbic acid will oxidize on the skin's surface and won't be absorbed  [13:00] If a vitamin was synthesized in a lab it is misleading to market them as natural [16:30] Rose hip. citrus and berry extracts are a great resource for natural Vitamins for skin [18:20] Retinols are actually very irritating and are banned by many ingredient safety sites [22:00] Natural products have shorter shelf lives because they avoid preservatives [23:15] Beauty is NOT pain! You should never need a day off from your products if they are safe [27:00] Exfoliating your face can cause damage and should not be done more than twice month [29:30] Dry brushing is a great way to exfoliate your body [34:00] Since the weather affects your skin your skincare routine may change with every season   Mentioned in This Episode: https://createyourskincare.com  https://skinwellnesspro.com/ Instagram: https://www.instagram.com/rachaelpontillo/ Facebook: https://www.facebook.com/HolisticallyHaute/ Free Gift or Offer Link:https://createyourskincare.com/4-step-balanced-skincare-regimen/ Twitter: “They have been preserved so strongly, so that by the time you get them, sometimes 3 to 5 years after they were manufactured, that's not great. There is nothing fresh about it. There is nothing about it that is going to get into the skin and your skin is going to be like, “Oh this is what I need!”, because the skin doesn't take in nutrients like that, it takes in nutrients from  the food you eat.” [8:30]   “Our skin's barrier is primarily a lipid matrix, it's meant to keep things out. So anything that is water soluble is going to have a harder time getting in on its own.”  [10:57]   “Is this skin care as in nutrients or is this a lab experiment going on on our faces? Where these ingredients have been synthesized and they haven't really been around long enough to really know what is the long term effect of this.”  [12:30]   “When we force exfoliation, what it does is it exposes cells, that are not fully developed yet, to the elements.”  [18:40]   Podcast Disclaimer:  https://resources.thespadr.com/the-womans-doctor/#disclaimer

A crash course in knowing the differences between retinoids and retinols, what they do, who uses them, how to use them and when to start using them.

Hi, Beauties! This time we are discussing one of my favorite products, Retinol! We know the magical abilities Retinol has of turning back the clock by erasing and preventing fine lines and wrinkles. But let's be real, sometimes Retinol can be a little harsh on our skin! I am here to bring you up to speed on some less irritating alternatives to Retinols when to use them, and some of the pros and cons. Listen for more!

Double ur pleasure, double yo fun with our DOUBLE FEATURE! We call it DOUBLE because there's two of us and we wanna FEATURE some sh*t.☺ This segment is where J and Lesly talk about some of our favorite things. It can be a artist, tv show, music, business, book or anything. Our Double Feature for this episode is the holy grail skincare product that erases all your problems, RETINOL/RETIN-A/RETINOIDS/VITAMIN A and we get personal talk about moving bowls with Source Naturals: Daily Essential Enzymes® Every Wednesday we rotate between 3 segments called: Double Feature, some Science Sh*t, and our Thotful Moment. But this Saturday we recap & review… Avatar: The Last Airbender! Au revoir !! —————————————————— FOLLOW US on INSTAGRAM @HomoInTraining Find us on Facebook! LIKE & FOLLOW our page! EMAIL US your favorite tingz: HomoInTrainingPodcast@gmail.com —————————————————— Music Credit: Jazzy Abstract Beat by Coma-Media —————————————————— --- Send in a voice message: https://anchor.fm/homointraining/message

In this episode of Tried and Thoroughly Tested, phenomenal beauty science journalist Becki Murray talks us through the two mild retinols that have performed the best during the most thorough of trials.Both of the retinols mentioned are mild enough to use on most sensitive skins, increase hydration and with long term use will have the beneficial effects that you would expect to see from stronger and more intense vitamin A derivatives.I love hearing Becki's thorough and informed product reviews and can't wait for you to find out more about two phenomenal products.Do follow Becki @beckimurray_ for lots of excellent information and great beauty content.

Kate ditches a planner and Doree remembers that the advice you'd give to a friend is maybe the best advice to give yourself. Then, they answer listener questions about how to get into retinol, how to bring more fun into your life, and if there's any real benefit to staying loyal to a single skincare brand. To leave a voicemail or text for a future episode, reach them at 781-591-0390. You can also email the podcast at forever35podcast@gmail.com.Visit forever35podcast.com for links to everything they mention on the show.Follow the podcast on Twitter (@Forever35Pod) and Instagram (@Forever35Podcast) and join the Forever35 Facebook Group (Password: Serums). Sign up for the newsletter! At forever35podcast.com/newsletter.This episode is sponsored by:COLORGURU - Get 10% off any color consultation at yourcolorguru.com when you enter promo code FOREVER at checkout.ATHLETIC GREENS - Visit athleticgreens.com/forever35 to take control of your health and give AG1 a try today.BETTER HELP - Get 10% off your first month with the discount code FOREVER35. Go to betterhelp.com/FOREVER35 to get started today.PROSE - Get a FREE consultation and 15% off custom hair supplements! Go to Prose.com/forever35.JENNI KAYNE - Get 15% off your first order at jennikayne.com when you use code FOREVER35 at checkout. See acast.com/privacy for privacy and opt-out information.

A literature review of the true potential of retinol products and if we all need them in our skincare routine. --- Send in a voice message: https://anchor.fm/skincareanarchy/message Support this podcast: https://anchor.fm/skincareanarchy/support

You know how many people say that you can't use Retinol in Summer? That's a capital M - Myth. Retinol does increase your skin's sensitivity to the sun but it's still perfectly safe (and recommended) to use. This is why Fall is the perfect season to introduce Retinol in your skincare routine! The sun's less intense and by the time Summer comes around, you would've gotten used to it already!   So today, let's talk about Retinol incorporation and remind you why it's a component of the 5-Step Skin Success Framework.     In this episode, we'll discuss: The 2 main factors to consider when introducing Retinol during Fall Why Retinol is a must for youthful, glowing skin How to choose the right Retinol product at the right time     Resources: Pumped to go all out with your Skincare Routine? I'm now accepting waitlist applications for the first round of The Healthy Skin Blueprint. Text “PODCAST” to 480-530-8187 to get a weekly skincare routine reminder & affirmation.     Disclaimer:  The Dr. Nikoleta Show is for informational purposes only. It is not medical advice. Please consult with your physician before implementing any of the information. Copyright Dr. Nikoleta 2021.  

In Part 2 of our chat with Dermatology PA-C Stephanie Cullinane, we focus on the cosmetic side of her practice. Stephanie discusses how to choose and use skin care products, ways to turn over skin, and more. We end with a Dermatology Rapid-Fire. Stephanie specializes in both medical and cosmetic dermatology at Aesthetic Dermatology & Skin Cancer in the San Francisco Bay Area. If you haven't already, listen to Part 1 of our chat, where we  focus on the medical side of her practice.HERE'S WHAT WE DISCUSSED WITH STEPHANIE CULLINANE IN PART 2 OF OUR CHAT:How to pick out a cleanser - it's all in the pHGetting dry with ageHow to moisturizeIt's all about molecule size  Antioxidant productsCalming down pigment cellsVitamin C serumsVitamin B3 in sunscreensDNA repair productsWhere to put your moneyAcid peels and lasersEye creams and eyelid rashesHow to use Retinols and Retin-AStimulating collagenSun damage and cell memoryCONNECT WITH RAW FEMALEJoin our email list and we'll remind you when new episodes drop. Follow us on Instagram at @rawfemalepodcastIf you enjoyed this episode or learned something new, forward to a friend!And don't forget to subscribe wherever you get your podcasts!Raw Female: Informational. Positive. Solution-based. Fun.

Budget Friendly Skincare Products by Category Part 1Exfoliants:Cos de Baha 2% Salicylic Acid Liquid$15 does contain lavender extracthttps://ys.style/BSRBiYuTVibThe Ordinary Lactic Acid 10% +HA$9https://fxo.co/Cbd5Good Molecules Overnight Exfoliating Treatment$6https://fxo.co/Cbd6Wishtrend 5% Prep Toner$15https://ys.style/ONCr4oaf4ibRetinols:Versed Press Reset Gentle Retinol Serum$22 Fragrance Freehttps://goto.target.com/YgyvJKGood Molecules Gentle Retinol Cream$8Available at BeautylishRevolution Skincare Retinol Overnight Cream$15 Fragrance Freehttps://tidd.ly/2WCa4GCThe Ordinary Granactive Retinoid 2% Emulsion$9.80 Fragrance Free, Hydroxypinacolone Retinoate, Retinolhttps://fxo.co/Cbq0Acne Products:My Touch Skincare Acne Treatment 2.5% Benzoyl PeroxideFragrance Free, $19Neutrogena Stubborn Acne AM Treatment$13 2.5% Benzoyl Peroxidehttps://fxo.co/Cbq9bioClarity Treat Acne Clearing Gel$14, 2% Salicylic Acidhttps://fxo.co/CWtNTime Stamps00:00:00 Welcome00:21:21 Exfoliants 02:09:04 Retinols03:56:16 Acne Treatments*******Podcast LinksApple - https://b.link/No_BS_Apple_PodcastGoogle - https://b.link/No_BS_Google_PodcastAmazon - https://b.link/No_BS_Amazon_PodcastSpotify - https://b.link/No_BS_Spotify_PodcastStitcher - https://b.link/No_BS_Stitcher_PodcastRSS - https://feeds.redcircle.com/671dd1b2-a989-41d5-94d5-30c014e06149********Sephora - https://fxo.co/1231867/sephoraUlta - https://fxo.co/1231867/ultaAmazon - https://www.amazon.com/shop/nobsbeautyYes Style - https://ys.style/kk2Vjrv798Style Korean - http://www.stylekorean.com/?af_id2=nobsbeautyThese are affiliate links if you purchase anything from one of these stores using this link No BS Beauty will make a small commission on what you buy.********I am proud to offer my very own beauty products at Amazon. We are starting small but hope to grow these offerings. Take a look and if you can pick one or two up, it helps keep this channel truly independent.My Products:No BS Beauty Travel Set - https://amzn.to/2PgPzFZNo BS Beauty Airless Jars - https://bit.ly/2Ev6X6N or https://amzn.to/2RCEq4sNo BS Beauty Color Switcher - https://amzn.to/2RCEAJ6See my own page on Amazon - https://www.amazon.com/shop/nobsbeautywww.noBSbeauty.net*******My Patreon - https://www.patreon.com/noBSbeauty*******PayPal Tip Jar - https://bit.ly/donate_NBSBIf you want to leave a tip ... Thanks! *****Since so many of you asked for it, here is a link to my favorite PH testing strips https://amzn.to/33ojjIY

From exfoliation to exposing your skin to tons of toxins daily, how do we know whats correct for proper skin care anymore? In this episode, Jennifer covers exactly why retinols are scientifically proven to change your skin and alter acne, tissue tightening, and aging. The important part to understand is there are different types of retinol and understanding what your skin type needs is matters when trying to achieve results.  This episode even includes how our skincare uses should be seasonal based on sun exposure and drier months. If you're ready to book your skin care treatment with a true expert: https://virago.studio/  

You've heard the promises: Eye creams reduce or even erase the signs of aging: fine lines, wrinkles, and dark circles. But aren't eye creams just more-expensive moisturizers in a smaller package? Tune in this week to get your answer!   Featured Product Organixx Skin:  Renew Eye Cream   * * *   Do You Really Need Eye Cream? Did you know your eyes can look up to 20 years older than the rest of your face? This is due to those pesky concerns like dark circles and puffiness around the eye. Dark circles occur because the skin below the eye is so thin it actually shows the blood pumping around - the eye puffiness further exacerbates this. You've heard the promises: Eye creams reduce or even erase the signs of aging: fine lines, wrinkles, and dark circles. But aren't eye creams just more-expensive moisturizers in a smaller package? Not necessarily, says dermatologist Patricia Farris, MD, a clinical associate professor at Tulane University School of Medicine. "Eye creams are formulated specifically for the delicate skin around the eye, so they tend to be thicker. They contain more oil than a regular facial lotion, and they have a lot of active ingredients aimed at the problems we see around the eyes," Farris explains. The skin around the eyes is more fragile, more prone to dryness, and quicker to show age and fatigue. Squinting and constant movement of the eyes also hasten the appearance of lines and wrinkles, and fluids collect under the eyes and cause puffiness and dark circles. Eye creams can address some of these issues. Here’s an unsettling thought: the skin around the eye loses moisture around 50% faster than the rest of your face, so it’s actually the driest area of your face. However, the skin is so delicate it doesn’t show patchy dryness on the surface, like the rest of our face, even though it’s the most vulnerable area.   Top 5 Reasons You Want to Use an Eye Cream 1. MINIMIZE THE LOOK OF DARK CIRCLES Nothing highlights your lack of sleep more than a set of dark circles hanging around your eyes. When you’re tired, a chemical called cortisol builds up in your body to give you energy to stay awake. This internal energy shot causes blood vessels to inflate, causing them to push up against the thin skin around your eyes creating dark circles. Yes, one of the well-known uses for under eye cream is to help mask those dark under eye circles. There are many products out there claiming to do just this, so considering the ingredients in each is key. Dark circles under the eyes come from genes, sun damage, age, and blood build-up. Sodium ascorbate, or vitamin C, can thicken the skin and help conceal dark circles after about 6 months.    2. SAY GOODBYE TO PUFFINESS You’ve likely fallen victim to under eye bags at some point. Lack of sleep is no joke–and surely not the look you’re going for. Due to the horizontal nature of sleeping, blood and fluid accumulate beneath your eyes every night as you sleep. When you wake up, your body takes time to trickle these fluids back into the body (it can take even longer if you’re tired).    3. REDUCE WRINKLES Whether you’re a victim of smile-lines or sun damage, under eye wrinkles are a fact of life. Luckily, there are a few products you can use to help reduce them and keep your skin looking youthful. Fine lines and wrinkles come from both sun damage and your skin making less collagen as you age. Collagen helps maintain skin's elasticity. Vitamin C, peptides, and retinol have boosted collagen production, studies of skin creams show. Ceramide and hyaluronic acid also help; these are moisturizers that help prevent water loss in the skin and improve elasticity.   4. PREVENT WRINKLES Of course, getting rid of present wrinkles is something most of us think to do, but many people neglect the importance of prevention. Being proactive about potential wrinkles by using anti-aging products will save yourself the stress and hassle of waiting until they appear Skin around the eyes is 40 per cent thinner and it’s also the least elastic part of your face. That means it doesn’t have the bounce back that your cheeks might have, even though we tend to focus mostly on the complexion at large–big mistake. Organixx’s RENEW can work hard to undo your sins, even if they run deep, and it will continue to protect the delicate area by hydrating the skin and improving its softness and elasticity. The product contains witch hazel, an anti-inflammatory, meaning it will protect from environmental stressors too.   5. PREP YOUR SKIN FOR MAKEUP While there are plenty of products that will prep your skin for your daily makeup routine, under eye cream is one that most people overlook. With its firming and smoothing qualities, it has the power to make all the difference in how your makeup applies and wears throughout the day. It's important to note here that this doesn’t just pertain to women. Men benefit greatly from a healthy skincare regimen as well!   3 Ingredients You Should Never Put Near Your Eyes New beauty and skin care products surface every day with promises of better, younger-looking eyes. But before you apply them on and around your peepers, you might (read: definitely) want to check the ingredient list on the back. We discussed the top ingredients to avoid in your skincare on episodes 55 & 56. Be sure to check those out if you haven’t already! According to New York oculoplastic surgeon Irene Gladstein, MD, your go-to product probably contains an irritant that may be pose a threat to your eye health. “There is a myriad of skin care ingredients that, when used in close proximity to the eye, may cause undesirable—and frankly dangerous—ophthalmic concerns.“   Here are the top three culprits to look out for in order to keep sensitivity far, far away. Parabens Found in most products that contain any amount of water, Dr. Gladstein says preservatives like parabens and benzalkonium chloride (BAK) are common in makeup and skin care products, as well as makeup removers. While preservatives work to prevent bacteria from forming in your products, ingredients like parabens or BAK can also cause adverse reactions in some when placed too close to the eye.   Heavy metals “Nickel and chrome, two heavy metals seen in all sorts of makeup products, are known to be responsible for skin and eye allergies,” explains Dr. Gladstein. However, don’t confuse these with metals such as iron, which plays an important role in our body and is necessary for proper function.   Retinols Don’t worry: Retinols are still the gold standard of anti-aging ingredients. But, Dr. Gladstein says you have to be careful about where (and how carefully) you apply it. “When used in close proximity to the sensitive lining of the eye, retinols may precipitate dry eye and significant irritation.” The solution: Don’t get too close to your eye and use a retinol that’s specifically formulated for use in that area instead of your facial retinol. (Many will contain hydrating ingredients that will soothe or minimize any irritation around the delicate area.)   Renew Eye Cream New product from Organixx. All of the ingredients are USDA-certified organic ingredients. TeriAnn has formulated it.  * * *   Deeper Dive Resources Organixx Skin:  Renew Eye Cream https://organixx.com/skin-renew/?gl=5de7dd8802e26b3166323750   Organixx Skin: Restore Vitamin C Serum https://organixx.com/skin-restore?gl=5db097ce02e26bf576c26cd0   Environmental Working Group Skin Deep Cosmetics Database https://www.ewg.org/skindeep/   Empowering You Organically Podcasts on Skincare Ingredients Part 1: 55 Part 2: 56

You've heard the promises: Eye creams reduce or even erase the signs of aging: fine lines, wrinkles, and dark circles. But aren't eye creams just more-expensive moisturizers in a smaller package? Tune in this week to get your answer!   Featured Product Organixx Skin:  Renew Eye Cream   * * *   Do You Really Need Eye Cream? Did you know your eyes can look up to 20 years older than the rest of your face? This is due to those pesky concerns like dark circles and puffiness around the eye. Dark circles occur because the skin below the eye is so thin it actually shows the blood pumping around - the eye puffiness further exacerbates this. You've heard the promises: Eye creams reduce or even erase the signs of aging: fine lines, wrinkles, and dark circles. But aren't eye creams just more-expensive moisturizers in a smaller package? Not necessarily, says dermatologist Patricia Farris, MD, a clinical associate professor at Tulane University School of Medicine. "Eye creams are formulated specifically for the delicate skin around the eye, so they tend to be thicker. They contain more oil than a regular facial lotion, and they have a lot of active ingredients aimed at the problems we see around the eyes," Farris explains. The skin around the eyes is more fragile, more prone to dryness, and quicker to show age and fatigue. Squinting and constant movement of the eyes also hasten the appearance of lines and wrinkles, and fluids collect under the eyes and cause puffiness and dark circles. Eye creams can address some of these issues. Here’s an unsettling thought: the skin around the eye loses moisture around 50% faster than the rest of your face, so it’s actually the driest area of your face. However, the skin is so delicate it doesn’t show patchy dryness on the surface, like the rest of our face, even though it’s the most vulnerable area.   Top 5 Reasons You Want to Use an Eye Cream 1. MINIMIZE THE LOOK OF DARK CIRCLES Nothing highlights your lack of sleep more than a set of dark circles hanging around your eyes. When you’re tired, a chemical called cortisol builds up in your body to give you energy to stay awake. This internal energy shot causes blood vessels to inflate, causing them to push up against the thin skin around your eyes creating dark circles. Yes, one of the well-known uses for under eye cream is to help mask those dark under eye circles. There are many products out there claiming to do just this, so considering the ingredients in each is key. Dark circles under the eyes come from genes, sun damage, age, and blood build-up. Sodium ascorbate, or vitamin C, can thicken the skin and help conceal dark circles after about 6 months.    2. SAY GOODBYE TO PUFFINESS You’ve likely fallen victim to under eye bags at some point. Lack of sleep is no joke–and surely not the look you’re going for. Due to the horizontal nature of sleeping, blood and fluid accumulate beneath your eyes every night as you sleep. When you wake up, your body takes time to trickle these fluids back into the body (it can take even longer if you’re tired).    3. REDUCE WRINKLES Whether you’re a victim of smile-lines or sun damage, under eye wrinkles are a fact of life. Luckily, there are a few products you can use to help reduce them and keep your skin looking youthful. Fine lines and wrinkles come from both sun damage and your skin making less collagen as you age. Collagen helps maintain skin's elasticity. Vitamin C, peptides, and retinol have boosted collagen production, studies of skin creams show. Ceramide and hyaluronic acid also help; these are moisturizers that help prevent water loss in the skin and improve elasticity.   4. PREVENT WRINKLES Of course, getting rid of present wrinkles is something most of us think to do, but many people neglect the importance of prevention. Being proactive about potential wrinkles by using anti-aging products will save yourself the stress and hassle of waiting until they appear Skin around the eyes is 40 per cent thinner and it’s also the least elastic part of your face. That means it doesn’t have the bounce back that your cheeks might have, even though we tend to focus mostly on the complexion at large–big mistake. Organixx’s RENEW can work hard to undo your sins, even if they run deep, and it will continue to protect the delicate area by hydrating the skin and improving its softness and elasticity. The product contains witch hazel, an anti-inflammatory, meaning it will protect from environmental stressors too.   5. PREP YOUR SKIN FOR MAKEUP While there are plenty of products that will prep your skin for your daily makeup routine, under eye cream is one that most people overlook. With its firming and smoothing qualities, it has the power to make all the difference in how your makeup applies and wears throughout the day. It's important to note here that this doesn’t just pertain to women. Men benefit greatly from a healthy skincare regimen as well!   3 Ingredients You Should Never Put Near Your Eyes New beauty and skin care products surface every day with promises of better, younger-looking eyes. But before you apply them on and around your peepers, you might (read: definitely) want to check the ingredient list on the back. We discussed the top ingredients to avoid in your skincare on episodes 55 & 56. Be sure to check those out if you haven’t already! According to New York oculoplastic surgeon Irene Gladstein, MD, your go-to product probably contains an irritant that may be pose a threat to your eye health. “There is a myriad of skin care ingredients that, when used in close proximity to the eye, may cause undesirable—and frankly dangerous—ophthalmic concerns.“   Here are the top three culprits to look out for in order to keep sensitivity far, far away. Parabens Found in most products that contain any amount of water, Dr. Gladstein says preservatives like parabens and benzalkonium chloride (BAK) are common in makeup and skin care products, as well as makeup removers. While preservatives work to prevent bacteria from forming in your products, ingredients like parabens or BAK can also cause adverse reactions in some when placed too close to the eye.   Heavy metals “Nickel and chrome, two heavy metals seen in all sorts of makeup products, are known to be responsible for skin and eye allergies,” explains Dr. Gladstein. However, don’t confuse these with metals such as iron, which plays an important role in our body and is necessary for proper function.   Retinols Don’t worry: Retinols are still the gold standard of anti-aging ingredients. But, Dr. Gladstein says you have to be careful about where (and how carefully) you apply it. “When used in close proximity to the sensitive lining of the eye, retinols may precipitate dry eye and significant irritation.” The solution: Don’t get too close to your eye and use a retinol that’s specifically formulated for use in that area instead of your facial retinol. (Many will contain hydrating ingredients that will soothe or minimize any irritation around the delicate area.)   Renew Eye Cream New product from Organixx. All of the ingredients are USDA-certified organic ingredients. TeriAnn has formulated it.  * * *   Deeper Dive Resources Organixx Skin:  Renew Eye Cream https://organixx.com/skin-renew/?gl=5de7dd8802e26b3166323750   Organixx Skin: Restore Vitamin C Serum https://organixx.com/skin-restore?gl=5db097ce02e26bf576c26cd0   Environmental Working Group Skin Deep Cosmetics Database https://www.ewg.org/skindeep/   Empowering You Organically Podcasts on Skincare Ingredients Part 1: 55 Part 2: 56

When you're pregnant there's a million things you have to steer clear of and some beauty products are on that list. Kelly and Leigh (who herself is pregnant!) sit down and chat what products you can and can't use while pregnant and breastfeeding. Plus is there actually any proven results when it comes to preventing and minimising stretch marks? And in our Spendy/Savey, Leigh brings her favourite pregnancy-safe, and cheap, product from Weleda If you're in NSW you can call MotherSafe for advice on 1800 647 848 Or alternatively you can call HealthDirect nation wide on 1800 022 222  You can find all the products from today's episode here: https://www.mamamia.com.au/pregnancy-safe-skincare/CREDITS Hosts:Leigh Campbell and Kelly McCarren Producer:Rachael HartGET IN TOUCH: You Beauty is a podcast by Mamamia. Find more shows here .... https://www.mamamia.com.au/podcast/ Got a beauty question you want answered?  Email us at podcast@mamamia.com.au or call the podphone on 02 8999 9386.  Join our You Beauty Facebook Group here...  https://www.facebook.com/groups/2112109512358240/ Want this and other podcasts delivered straight to your inbox?  Subscribe to our podcast newsletter...  https://www.mamamia.com.au/subscribe/

If you have been prescribed, or are eyeing up those over-the-counter retinol-based products, to improve wrinkles, fine lines and imperfections, Nurse Paula tells you what the differences are, how to properly use them, and what to watch out for. http://youngmedicalspa.com

Das Ziel der vorliegenden Arbeit war es, molekulare Vorgänge während der B-Zellentwicklung in der Bursa Fabricii des Haushuhns mittels proteomischer Analysen zu charakterisieren. Hierfür wurden zunächst repräsentative Zeitpunkte der bursalen B-Zellentwicklung für die Probengewinnung definiert. Daran schlossen sich qualitative Proteomanalysen der Bursa Fabricii zu den gewählten Entwicklungszeitpunkten Embryonaltag 10 (ET10), Embryonaltag 18 (ET18), Tag 2 und Tag 28 nach dem Schlupf an. Diese erfolgten durch Vorfraktionierung der Proben mittels 1D-SDS-PAGE und nano-HPLC gefolgt von Tandem-MS-Analysen. Hierbei konnten für die bursalen Proteome zu jedem Zeitpunkt zwischen 1152 und 1392 Proteine identifiziert werden (FDR < 1 %). Überschneidungen der einzelnen Zeitpunkte in 537 allgemeinen Struktur- und Stoffwechsel-Proteinen berücksichtigt, wurden insgesamt 2214 verschiedene Proteine identifiziert. Eine zusätzliche qualitative Analyse aufgereinigter bursaler B-Zellen führte zur Identifizierung von 758 Proteinen. Durch genontologische Analysen konnte festgestellt werden, dass für das Zellwachstum verantwortliche Proteine va. zu den frühen Zeitpunkten zu finden waren, während Proteine, welche eine Rolle für das Immunsystem spielen, eher zu späteren Entwicklungszeitpunkten in Erscheinung traten. Dies spiegelt die Entwicklung der Bursa von der unreifen, embryonalen Wachstums- und Differenzierungsprozessen unterliegenden Bursaanlage, zum fertig ausdifferenzierten, primär-lymphatischen Organ auf molekularer Ebene wider. Konform zu den hohen Proliferationsraten der B-Zellen während der Bursaentwicklung fanden sich in den genontologischen Analysen der B-Zellen besonders hohe Anteile an Proteinen, welche für Zellteilung verantwortlich sind. Proteine, welche in Zusammenhang mit Zellmigration stehen, wurden vor allem in der B-Zell-Probe sowie an ET10 gefunden, was als Hinweis auf eine Beteiligung dieser Proteine an der Einwanderung der B-Zellen in die Bursaanlage betrachtet werden kann. Die anschließende quantitative Proteomanalyse wurde zu denselben Entwicklungszeitpunkten an je sechs biologischen Replikaten mittels 2D-DIGE durchgeführt. In der statistischen Auswertung der quantitativen Veränderungen zeigten sich 402 hochsignifikante Unterschiede zwischen den bursalen Proteomen der verschiedenen Entwicklungszeitpunkte, wobei die sehr große Übereinstimmung der Analyseergebnisse innerhalb der biologischen Replikate die gute Reproduzierbarkeit der Experimente belegte. Die deutlichsten Veränderungen zeigten sich zwischen ET10 und allen weiteren Zeitpunkten, wohingegen innerhalb der übrigen Stadien eine geringere Anzahl signifikanter Unterschiede nachgewiesen wurde. Für die 402 differentiell exprimierten Proteine konnten verschiedene charakteristische Protein-expressionsverläufe nachgewiesen werden, welche Rückschlüsse auf die biologischen Hintergründe ermöglichten. Durch massenspektrometrische Analysen der Proteine mittels MALDI-TOF/TOF und LC-MS/MS gelang es, 203 der 242 zur Identifikation vorgesehenen Spots zu identifizieren. Im Rahmen einer bioinformatischen Auswertung des erhaltenen Datensatzes erbrachten sowohl die genontologische Analysen als auch Pathway-Analysen wesentliche Anhaltspunkte für die Auswahl besonders interessanter und vielversprechender Proteine für weiterführende funktionelle Analysen. Unter den identifizierten, differentiell exprimierten Proteinen fanden sich auffällig viele Vertreter des Aktin-Zytoskelett-Pathways, welcher für die mechanische Stabilisierung von Zellen und deren aktive Bewegungen verantwortlich ist. Dabei fielen in dieser Arbeit sowohl Vinculin als auch Gelsolin durch ihre charakteristischen Expressionsmuster auf. Vinculin zeigte zu Beginn der embryonalen Entwicklung erhöhte Abundanzwerte, welche nach ET18 steil abfielen. Als fokales Adhäsionsprotein stellt es ein Schlüsselprotein in der Regulation der Übertragung von kontraktilen Kräften dar, welche die Voraussetzung für die Migration von Zellen sind. Gelsolin, ein wichtiges Apoptose-Effektorprotein, welches auch in Verbindung mit Zellmotilität gebracht wird, zeigte erhöhte Expressionslevel an ET18, welche über die nachfolgenden Entwicklungszeitpunkte abfielen. Gelsolin konnte in drei verschiedenen Ladungs-Isoformen detektiert werden. Für die Fragestellung dieser Arbeit interessant erschien weiterhin eine Gruppe differentiell exprimierter Proteine des Retinolsäure-Metabolismus. Im Einzelnen wurden die Retinaldehydrogenase 2 (ALDH1A2), das „retinol-binding protein 5“ (RBP5), das „fatty acid-binding protein 7“ (FABP7), und Transthyretin (TTR) mit ähnlichen Proteinexpressions-profilen detektiert, welche ihr Expressionsmaximum jeweils an ET10 aufwiesen. Das könnte ein Hinweis sein, dass die embryonale Entwicklung der Bursa Fabricii von ähnlichen Faktoren gesteuert ist wie die embryonale Ausbildung der sekundär-lymphatischen Organe beim Säuger, bei der Retinolsäure-abhängige Proteine eine entscheidende Rolle spielen. Über die Thematik dieser Arbeit hinausgehend, stellt der umfangreiche proteomische Datensatz dieser Arbeit eine wertvolle Ressource dar, die sowohl für weitere Fragestellungen bezüglich der Bursa Fabricii des Huhns, als auch für die Vervollständigung der Annotation des Hühnergenoms genutzt werden können.

In dieser Arbeit wurde die biologische Funktion der PTP-Meg2 in der zellulären Signaltransduktion untersucht. Analysen mittels c-DNA-Filter, „Real Time PCR” und Immunblot zeigen eine ubiquitäre Expression der PTP-Meg2 auf ähnlichem, jedoch geringem Niveau in fast allen untersuchten Krebszelllinien unterschiedlicher Gewebeherkunft, wobei die Expressions-stärke nicht in direktem Zusammenhang mit krebsrelevanten Eigenschaften wie Invasivität und Metastasierung steht. Die induzierte Differenzierung von MCF 7-Zellen durch Natriumbutyrat steigert die Meg2-Expression um das 5-fache, wogegen die Differenzierung von SW948- und SK-N- SH-Zellen mit TPA bzw. Retinolsäure die Meg2-Expression reprimiert. Zellfraktionierung und Immunfluoreszenz zeigen eine primär zytosolische, aber partiell auch vesikuläre bzw. strukturierte Lokalisation der PTP-Meg2, für welche die CRALBP-Domäne der PTP-Meg2 mitverantwortlich ist. Untersuchungen der endogenen Meg2-Aktivität nach Immunpräzipitation und in vitro Phosphatasetests zeigen eine erhöhte Phosphataseaktivität nach Stimulation von Zellen mit FCS, EGF und LPA, wogegen TPA stark inhibierenden wirkt. Aktivitätsstudien mit GST-Meg2-Fusionsproteinen zeigen, dass die CRALBP-Domäne die Meg2-Phosphataseaktivität negativ reguliert. Im Protein-Lipid-Overlay interagiert PTP-Meg2 mit PI(3)P, PI(4)P, PI(5)P und Phosphatidylserin. Eine Interaktion mit PI(4)P führt zu einer erhöhten Meg2 Aktivität. Pervanadat-Stimulation von Zellen führt zu einer Tyrosinphosphorylierung sowie einer Mobilitätsänderung der PTP-Meg2, was auch mit einer katalytisch inaktiven Meg2-Mutante beobachtet wurde. PTP-Meg2 interagiert in vitro und in Koexpressionsstudien mit dem EGF-Rezeptor in Abhängigkeit von dessen Aktivierung. Eine physiologische Relevanz konnte nicht gezeigt werden. Die Depletion der PTP-Meg2 durch spezifische siRNA führt zu einer erhöhten Tyrosinphosphorylierung einiger, noch zu identifizierender Proteine. PTP-Meg2 vermindert, die inaktive PTP-Meg2CS-Mutante erhöht die durch v-ErbB und EGF-Rezeptor, nicht aber die durch HER2 und v-Ki-Ras induzierte Transformation von NIH3T3-Zellen im Focusbildungstest. Zudem bewirkt PTP-Meg2CS, mit Ausnahme der v-Ki-Ras infizierten Zellen, eine leicht erhöhte ERK1/2-Aktivität. Ferner stimuliert PTP-Meg2 die Migration von NIH3T3-Zellen im Wundheilungsexperiment. Ein Einfluss auf die basale und durch Stimuli induzierte Proliferation von Zellen in Wachstumstests wurde nicht beobachtet. Ein durch siRNA-vermittelter Meg2- „knockdown“ führte zur Induktion bzw. Repression der Expression von Genen, wie z.B. einiger Liganden, Caveolin-2, Nck und Rock, was auf eine Beteiligung der PTP-Meg2 an der Regulation von Signalwegen kleiner GTPasen bzw. von endo- sowie exocytotischen Prozessen schließen lässt.