Podcasts about hormonal

POTS is a real diagnosis, but it isn't always the whole story. In this episode of Bendy Bodies, Dr. Linda Bluestein takes a deep dive into POTS imitators: conditions that can mimic, worsen, or coexist with postural orthostatic tachycardia syndrome and quietly derail treatment progress. Inspired by listener questions and real-world clinical patterns, the episode explores why some people do “everything right” for POTS and still don't improve.The conversation breaks down overlooked contributors like nutrient deficiencies (including pernicious anemia and thiamine deficiency), endocrine and hormonal conditions, mast cell activation, medication effects, sleep disorders, post-infectious syndromes, and neurologic or autoimmune drivers. Dr. Bluestein explains how normal labs can be misleading, why symptoms often appear before classic test abnormalities, and how multiple factors can converge on the same autonomic pathway.Rather than encouraging self-diagnosis, this episode offers a framework for asking better questions, helping listeners recognize red flags, avoid medical ping-pong, and advocate thoughtfully without overwhelming themselves or their clinicians. For anyone living with POTS symptoms that don't fully respond to treatment, this episode provides clarity, context, and a more nuanced way forward. Takeaways: POTS is a pattern, not always a root cause, and multiple conditions can drive the same autonomic symptoms. Normal routine labs do not rule out nutrient deficiencies, including B12 or thiamine deficiency. Hormonal, endocrine, mast cell, and neurologic factors frequently overlap, complicating diagnosis and treatment. Symptoms that persist despite appropriate POTS care are a signal to look deeper, not push harder. Thoughtful pacing and prioritization matter, helping patients avoid burnout while still advocating effectively. Want more Dr. Linda Bluestein, MD? Website: https://www.hypermobilitymd.com/ YouTube: https://www.youtube.com/@bendybodiespodcast Instagram: ⁠⁠⁠⁠https://www.instagram.com/hypermobilitymd/⁠⁠⁠⁠ Facebook: ⁠⁠⁠⁠https://www.facebook.com/BendyBodiesPodcast⁠⁠⁠⁠ X: ⁠⁠⁠⁠https://twitter.com/BluesteinLinda⁠⁠⁠⁠ LinkedIn: ⁠⁠⁠⁠https://www.linkedin.com/in/hypermobilitymd/⁠⁠⁠⁠ Newsletter: ⁠⁠⁠⁠https://hypermobilitymd.substack.com/ Shop my Amazon store ⁠⁠⁠ https://www.amazon.com/shop/hypermobilitymd Dr. Bluestein's Recommended Herbs, Supplements and Care Necessities: https://us.fullscript.com/welcome/hypermobilitymd/store-start Want to learn more about the UVA EDS Center? For Appointments and Questions: RUVAEDSCenter@uvahealth.org UVA EDS: https://www.uvahealth.com/healthy-practice/advancing-care-through-ehlers-danlos-clinic UVA EDS FAQ: https://www.uvahealth.com/support/eds/faq UVA Pediatric Integrative Medicine: https://childrens.uvahealth.com/specialties/integrative-health Thank YOU so much for tuning in. We hope you found this episode informative, inspiring, useful, validating, and enjoyable. Join us on the next episode for YOUR time to level up your knowledge about hypermobility disorders and the people who have them. Join YOUR Bendy Bodies community at ⁠⁠https://www.bendybodiespodcast.com/⁠⁠. YOUR bendy body is our highest priority!⁠⁠ Learn more about Human Content at ⁠⁠⁠http://www.human-content.com⁠⁠⁠ Podcast Advertising/Business Inquiries: ⁠⁠⁠sales@human-content.com⁠⁠⁠ Part of the Human Content Podcast Network FTC: This video is not sponsored. Links are commissionable, meaning I may earn commission from purchases made through links Learn more about your ad choices. Visit megaphone.fm/adchoices

POTS is a real diagnosis, but it isn't always the whole story. In this episode of Bendy Bodies, Dr. Linda Bluestein takes a deep dive into POTS imitators: conditions that can mimic, worsen, or coexist with postural orthostatic tachycardia syndrome and quietly derail treatment progress. Inspired by listener questions and real-world clinical patterns, the episode explores why some people do “everything right” for POTS and still don't improve.The conversation breaks down overlooked contributors like nutrient deficiencies (including pernicious anemia and thiamine deficiency), endocrine and hormonal conditions, mast cell activation, medication effects, sleep disorders, post-infectious syndromes, and neurologic or autoimmune drivers. Dr. Bluestein explains how normal labs can be misleading, why symptoms often appear before classic test abnormalities, and how multiple factors can converge on the same autonomic pathway.Rather than encouraging self-diagnosis, this episode offers a framework for asking better questions, helping listeners recognize red flags, avoid medical ping-pong, and advocate thoughtfully without overwhelming themselves or their clinicians. For anyone living with POTS symptoms that don't fully respond to treatment, this episode provides clarity, context, and a more nuanced way forward. Takeaways: POTS is a pattern, not always a root cause, and multiple conditions can drive the same autonomic symptoms. Normal routine labs do not rule out nutrient deficiencies, including B12 or thiamine deficiency. Hormonal, endocrine, mast cell, and neurologic factors frequently overlap, complicating diagnosis and treatment. Symptoms that persist despite appropriate POTS care are a signal to look deeper, not push harder. Thoughtful pacing and prioritization matter, helping patients avoid burnout while still advocating effectively. Want more Dr. Linda Bluestein, MD? Website: https://www.hypermobilitymd.com/ YouTube: https://www.youtube.com/@bendybodiespodcast Instagram: ⁠⁠⁠⁠https://www.instagram.com/hypermobilitymd/⁠⁠⁠⁠ Facebook: ⁠⁠⁠⁠https://www.facebook.com/BendyBodiesPodcast⁠⁠⁠⁠ X: ⁠⁠⁠⁠https://twitter.com/BluesteinLinda⁠⁠⁠⁠ LinkedIn: ⁠⁠⁠⁠https://www.linkedin.com/in/hypermobilitymd/⁠⁠⁠⁠ Newsletter: ⁠⁠⁠⁠https://hypermobilitymd.substack.com/ Shop my Amazon store ⁠⁠⁠ https://www.amazon.com/shop/hypermobilitymd Dr. Bluestein's Recommended Herbs, Supplements and Care Necessities: https://us.fullscript.com/welcome/hypermobilitymd/store-start Want to learn more about the UVA EDS Center? For Appointments and Questions: RUVAEDSCenter@uvahealth.org UVA EDS: https://www.uvahealth.com/healthy-practice/advancing-care-through-ehlers-danlos-clinic UVA EDS FAQ: https://www.uvahealth.com/support/eds/faq UVA Pediatric Integrative Medicine: https://childrens.uvahealth.com/specialties/integrative-health Thank YOU so much for tuning in. We hope you found this episode informative, inspiring, useful, validating, and enjoyable. Join us on the next episode for YOUR time to level up your knowledge about hypermobility disorders and the people who have them. Join YOUR Bendy Bodies community at ⁠⁠https://www.bendybodiespodcast.com/⁠⁠. YOUR bendy body is our highest priority!⁠⁠ Learn more about Human Content at ⁠⁠⁠http://www.human-content.com⁠⁠⁠ Podcast Advertising/Business Inquiries: ⁠⁠⁠sales@human-content.com⁠⁠⁠ Part of the Human Content Podcast Network FTC: This video is not sponsored. Links are commissionable, meaning I may earn commission from purchases made through links Learn more about your ad choices. Visit megaphone.fm/adchoices

"People have such a negative connotation around cardio. At the end of the day, you can have the flattest stomach, the nicest glutes, and the best biceps in the world but if your heart gives out, you still die. You can have a great body and still die. You need a strong heart to actually enjoy a high quality of life." If you've ever started a fitness plan with motivation, only to burn out, fall off, and start over again, you're not alone. In this episode, Maxime Sigouin returns to break down why most fitness approaches fail and what actually works for building a strong, lean, resilient body for life. Drawing on years of experience as a fitness coach, model, and Ironman triathlete, Maxime shares insights from his new book, Forever Fit. He explains how to build muscle, lose fat, improve metabolic health, and stay consistent without extremes, restriction, or burnout. You'll learn how to rethink protein, cardio, and recovery, and gain actionable guidance from Maxime that you can start applying today to transform your health. This episode also has a very special treat: We're thrilled to welcome UnchainedTV Founder Jane Velez-Mitchell as cohost with Raphael! What we discuss in this episode: Why Maxime's book stands out in the crowded health and fitness space.  How calorie deficits relate to fat reduction. Hormonal imbalances and aging. Strategies to keep workouts stimulating. What reverse dieting is, how it works, and what it can do for your metabolism. The truth about soy protein and the importance of protein diversity. How many days muscles need to recover for optimal growth. Why cardio is essential for overall health. Resources: Book: Forever Fit Website: Mavy Wellness  Forever Fit Podcast by Mavy Wellness - YouTube Instagram: MAVY Wellness - Become Forever Fit

What if the reason you cannot lose weight, think clearly, or stop craving sugar after dinner has nothing to do with discipline and everything to do with your hormones, your gut, and what you are eating at breakfast? These are the questions your doctor might not be asking or answering, but Jenn is.On this episode of Salad With a Side of Fries, Jenn Trepeck pulls back the curtain on the powerful Happy Healthy Hub community by sharing this Q&A from inside the hub. Covering hormonal weight gain, natural cholesterol remedies, healing leaky gut, taming food noise, boosting morning energy, and why protein intake early in the day is the most underrated tool for controlling sugar cravings and stubborn weight loss, it's likely your questions are included too! If you have ever felt like your body is working against you, this episode will help you understand why and what to do about it. For more Q & A, and answers to your personal questions, become a member of the Happy Healthy Hub here: https://asaladwithasideoffries.com/membership/What You Will Learn in This Episode:✅ Why hormonal weight gain and metabolic health are always the root cause of stubborn weight struggles and how willpower is never to blame, plus what actually depletes and replenishes this finite resource throughout your day.✅ How to naturally support cholesterol management through omega-3 supplements, soluble fiber, and reducing sugar and refined grains, and why coenzyme Q10 is essential for anyone currently taking a statin.✅ The key markers of gut health recovery, including zonulin testing and secretory IgA, and how repeated insults like antibiotics and artificial sweeteners compromise intestinal permeability over time.✅ How increasing protein intake earlier in the day dramatically reduces food noise, nighttime eating, and sugar cravings, and why satiety hormones like leptin and ghrelin are the real drivers behind your appetite.The Salad With a Side of Fries podcast, hosted by Jenn Trepeck, explores real-life wellness and weight-loss topics, debunking myths, misinformation, and flawed science surrounding nutrition and the food industry. Let's dive into wellness and weight loss for real life, including drinking, eating out, and skipping the grocery store.TIMESTAMPS: 00:00 Intro: You don't lack willpower, you're just spending your finite resources elsewhere throughout the day03:26 Natural cholesterol remedies using omega-3 supplements, soluble fiber, and reducing sugar/grain/starch intake07:13 Why coenzyme Q10 is critical for anyone on a statin and the disconnect between statin use and heart health outcomes09:47 Healing leaky gut: how to recognize recovery, what causes gut lining breakdown, and whether gut health and intestinal permeability damage can fully reverse15:34 Understanding food noise: how restriction, undereating, and low protein intake amplify cravings throughout the day and why low protein intake early in the day leads to nighttime eating20:46 Hormonal weight gain vs. metabolism: the roles of insulin, leptin, ghrelin, and satiety hormones in body weight24:50 How to stop sugar cravings after dinner by switching habits, increasing protein intake, and creating new meal-end rituals27:19 Warm water with lemon as a bedtime ritual: supporting digestion, gallbladder health, and signaling the end of meals naturally30:17 What is the easiest area to change first: nutrition, exercise, or health, and discussion of habits34:04 Jenn's go-to-tips for meal prep, cooking and takeout, favorite fitness activity and wellness habit that made the biggest difference42:00 Looking at health and wellness on social media and how it is tied to economics and the top wellness trends for 2026KEY TAKEAWAYS:

Send a textYou're doing everything right. You're moving your body, eating reasonably, getting some version of sleep. And yet your midsection has opinions, your energy is gone by 2pm, your sleep is wrecked, and your mood is doing things you don't recognize.Nobody warned you this was coming. This episode is your reality check and your permission slip.What This Episode Is AboutIn this episode, Alisha Carlson breaks down what's actually happening inside your body during perimenopause, the hormonal transition that can begin as early as your mid-thirties and affects virtually every system you rely on. If you've ever felt like your body stopped cooperating and couldn't figure out why, this is the episode with your answers.We cover:What perimenopause actually is and why it's not the same as menopauseThe five symptoms most commonly mistaken for personal failure: midsection weight gain, sleep disruption, fatigue, mood changes, and fitness plateausWhy fat redistributes to the midsection during perimenopause and why it has nothing to do with willpowerThe real reason your workouts stopped producing results (hint: it's your estrogen, not your effort)Why high-intensity exercise may actually be working against you right now and what to do insteadWhy strength training is the single most evidence-backed tool available to you in this phase of lifeWhy sleep is a fitness strategy, not a reward for being productive enoughHow to eat to support your hormones instead of fighting themFour better ways to measure your progress that actually tell you something usefulWho This Episode Is ForThis one is for the woman who is genuinely doing a lot, managing a career, raising kids, running a household, and still somehow ending up in a shame spiral because her body isn't responding the way it used to. If you've ever Googled "why am I gaining weight in my stomach" or "why am I so tired all the time" and gotten nowhere, pull up a chair. We're going there.Key TakeawaysYou are doing everything right. Hormonal changes during perimenopause can feel overwhelming and are not a reflection of your effort or disciplinePerimenopause is a natural transition that many women begin experiencing in their late thirties, not just their late fortiesHormonal fluctuations, not personal failure, are the direct cause of mood swings, sleep disruption, and changes in metabolismFat redistribution to the midsection during perimenopause is a physiological response to estrogen changes, not a lifestyle failureSleep quality is one of the most critical levers for overall health, fitness, and hormonal balance during perimenopauseStrength training is essential for maintaining muscle mass, metabolic health, and bone density and the research backs this up clearlyNutrition should focus on fueling your hormones and preserving muscle, not just restricting caloriesTracking progress should include energy, strength, and sleep quality, not just the scaleWomen need to adapt their fitness and nutrition strategies to work with their hormonal changes, not against themYou are not alone. Millions of women are navigating exactly this, and a strategy that fits your actual life existsReady to feel more like yourself again? head to alishacarlson.com to learn more about joining The Fit + Fueled Method or to schedule a consult

Welcome to Resiliency Radio with Dr. Jill Carnahan, where today's episode explores the powerful and transformative season of midlife—a time of hormonal shifts, identity changes, and profound personal reinvention. Dr. Jill is joined by Dr. Trevor Cates, bestselling author and pioneer in women's health, for an inspiring conversation about navigating perimenopause, purpose, and the courage to evolve. In this episode, Dr. Jill Carnahan and Dr. Cates discuss why midlife isn't a crisis—it's a reset. From hormonal fluctuations and metabolic changes to deeper emotional awakenings, this phase often acts as a "stress test," revealing what's no longer aligned in our health, work, and relationships. This conversation is for women who feel called to something more—more energy, more authenticity, more purpose—and want practical, holistic strategies to support both physical and emotional transformation. ✨ Like, subscribe, and share to help more women embrace midlife as a powerful new beginning.

"For women over 40, there is a lot we can do before we start or stop taking so many things. Get your hormones tested, understand your baseline, and then make decisions." — Renee Fitton In this episode of Turmeric & Tequila™, host Kristen Olson sits down with Renee Fitton, Vice President of Healthcare and Sales at ProLon, to unpack the often-overlooked but critical topic of women's health. From perimenopause to menopause, Renee shares her evidence-based approach to hormonal optimization and the science behind fasting mimicking diets (FMD). This conversation goes beyond surface-level wellness advice. Renee discusses the significant research gap between women's and men's health studies, the importance of establishing hormone baselines before making health decisions, and practical strategies for women over 40 to optimize their health naturally. The episode also touches on breaking free from restrictive eating patterns, the role of adaptogens and supplements, and what true success means in 2026. Whether you're in perimenopause, navigating menopause, or simply interested in longevity and hormone health, this episode offers actionable insights grounded in nutritional science and compassionate wellness guidance. Timestamps: 0:00 — Intro & Sponsors (Colorado Cloud Fish & Declan James Watches) 0:30 — Meet Renee Fitton: Introduction & Bio 1:15 — Who is Young Renee? Childhood & Personality Traits 3:45 — Renee's Career Path: Nutrition & Healthcare 6:30 — Women's Health: The Research Gap vs. Men's Studies 8:15 — What is Perimenopause? Definition & Timeline 10:40 — Hormonal Changes During Perimenopause & Menopause 13:00 — Science Behind Fasting Mimicking Diets (FMD) 15:30 — How Fasting Mimicking Benefits Women's Hormones 17:15 — ProLon & L-Neutra Health Tools 20:45 — Women's Relationship with Food & Restrictive Diets 22:30 — Hormone Testing: Why Baseline Matters 24:00 — Practical Steps for Women 40+ Before Medication 27:30 — Skincare, Collagen & Beauty from Within 29:15 — Adaptogens, Supplements & What Works 32:00 — Life Lessons & Personal Growth 34:30 — What Does Success Mean? (2026 Reflections) 36:45 — How to Connect with Renee (Contact Info & Resources) 38:30 — Outro & Final Thoughts Renee Fitton | Vice President, Healthcare & Sales at ProLon: Renee is a leader at the intersection of nutrition, healthcare, and education. As VP at ProLon, she equips healthcare practitioners with cutting-edge insights into nutrition and longevity. Her expertise in evidence-based nutritional science makes her a trusted authority in women's health, hormonal optimization, and fasting. She blends scientific rigor with compassionate wellness guidance. Connect with Renee: Instagram: @FittonNutrition Website: FitandNutrition.com ProLon: PROLONLIFE.com L-Neutra Health: Clinical fasting with dietitian support RESOURCES MENTIONED ProLon — Fasting Mimicking Diet Kits (PROLONLIFE.com) L-Neutra Health — Clinical fasting support with medical professionals Connect with T&T: IG: @TurmericTequila Facebook: @TurmericAndTequila Website: www.TurmericAndTequila.com Host: Kristen Olson IG: @Madonnashero Tik Tok: @Madonnashero Website: www.KOAlliance.com WATCH HERE   MORE LIKE THIS: https://youtu.be/ZCFQSpFoAgI?si=Erg8_2eH8uyEgYZF   https://youtu.be/piCU9JboWuY?si=qLdhFKCGdBzuAeuI https://youtu.be/9Vs2JDzJJXk?si=dpjV31GDqTroUKWH

In this episode of the Wise Divine Women Podcast, Dana Irvine discusses the importance of thermography in understanding functional health. She explains how thermography works, what it can detect, and who should consider getting a thermography. The conversation emphasizes the non-invasive nature of thermography, its role in preventative health, and the importance of understanding one's health through functional assessments. Dana also encourages listeners to reach out for more information and to explore local thermography options.Key takeawaysThermography is a non-invasive tool for health assessment.It helps identify inflammation and physiological changes.Thermography can detect hormonal imbalances and circulatory issues.The process involves mapping heat patterns in the body.Thermography is painless and does not involve radiation.Regular thermography can be part of a yearly health routine.It provides insights into overall health and wellness.Thermography is used alongside other diagnostic tools.Understanding your thermography report is crucial for health management.Thermography can help track progress and monitor health changes.If you're over 40 and feeling:• Tired but wired • Bloated or inflamed • Hormonal and frustrated • Concerned about breast health • Unsure what testing you truly needYou don't need another quick fix. You need clarity.The ⁠⁠Wise Divine Women Health Clarity Call ⁠⁠is your 1:1 strategy session to uncover root causes and map out your next best steps — whether that's functional testing, thermography, nutrition coaching, or hormone support.

Menopausal hormone therapy and long term mortality: nationwide, register based cohort study - LinkRisks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial - Link---Nova Android & iOS app MGFamiliar - ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Link⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠---Subscreva o Podcast MGFamiliar para não perder qualquer um dos nossos episódios. Além disso, considere deixar-nos uma revisão ou um comentário no Apple Podcasts ou no Spotify.---MusicHappy · MBB - Link—Este podcast destina-se a médicos e os conteúdos nele partilhados não devem ser usados para decisões individuais sem aconselhamento médico. Para tal, fale com o seu médico.

Scale Stalled? You're Not Broken.In this episode of The Dancing Housewife Podcast, I break down why fat loss after 40 — especially post-menopause — requires a smarter strategy, not more hustle.If you're lifting, walking, eating high protein/low carb, and the scale still won't budge, your metabolism didn't “break.” Early low-carb drops are mostly water from depleted glycogen. Real fat loss is slower — and strength training inflammation, hormone shifts, and water retention can easily mask progress.We talk about what actually changes after menopause: lower estrogen, altered insulin sensitivity, higher stress sensitivity, and why cortisol, recovery, and sleep matter more than ever. Working harder can backfire when your body feels stressed.You'll learn my menopause-smart reset and what not to do.If you're interested in being part of my newly forming Smart Weight Loss for Women group, leave a comment and be sure to include your email address or email me directly at thedancinghousewife@gmail.com. Let's lose weight smarter — not harder.

High cholesterol in menopause and perimenopause is shockingly common, and many women feel blindsided by sudden spikes in cholesterol, blood pressure, or even blood sugar in their 40s. Perimenopause isn't only about hot flashes and mood swings. Hormonal shifts can quietly influence your cardiovascular system, changing the story your labs are telling and leaving you asking, “What changed?”Joining me is Dr. Eve Henry, board-certified in Internal and Integrative Medicine and founder of Eve Henry MD. She brings deep expertise in personalized medicine and longevity science to help you understand what's happening and how to support your healthspan for the long run.⭐️Mentioned in This Episode:- See all the references

The Silent Threat Women Face Heart disease remains the number one killer of women in America, yet nearly half of all women fail to recognize it as their greatest health threat. During a recent Community Health episode of The Valley Today, host Janet Michael talks with Dr. April Shewmake, a board-certified interventional cardiologist at Winchester Cardiology and Vascular Medicine I Valley Health, to uncover the truth about cardiovascular health. What emerged was a compelling conversation that challenges common misconceptions and empowers listeners to take control of their heart health. Understanding the Specialist's Perspective Dr. Shewmake brings a unique dual expertise to her practice. As an interventional cardiologist, she treats heart attack emergencies in the catheterization lab using minimally invasive procedures to open blocked arteries. However, she emphasizes that general cardiology—the preventive side of her work—plays an equally vital role. "Before things become an emergency or a heart attack," she explains, "that's the general cardiology piece." This preventive approach focuses on long-term care, diagnostic imaging, and medication management to stop heart disease before it starts. The Prevention Paradox Perhaps the most striking revelation from the conversation centers on prevention. According to Dr. Shewmake, between 70 and 90 percent of heart disease is entirely preventable. This statistic transforms heart health from a matter of fate into one of choice. The key lies in daily habits that many people overlook: maintaining a healthy diet, exercising regularly, controlling blood pressure, managing stress, getting adequate sleep, and remaining tobacco-free. Nevertheless, Dr. Shewmake acknowledges that genetics do play a role. Some patients develop heart disease despite doing everything right. This reality underscores why awareness and early detection remain crucial, even for those who maintain healthy lifestyles. Recognizing the Warning Signs When it comes to identifying potential heart problems, Dr. Shewmake urges people to pay attention to specific symptoms. The major warning signs include chest pressure, shortness of breath, fatigue, dizziness, nausea, and pain radiating to the jaw, arms, or back. Critically, symptoms that appear during physical exertion and improve with rest signal early-stage heart disease. Furthermore, Dr. Shewmake dispels the Hollywood myth that distinguishes heart attacks from indigestion. In reality, many people—particularly young adults and women—delay seeking treatment because they assume their symptoms indicate simple indigestion. Women especially tend to experience atypical presentations, manifesting nausea and shortness of breath rather than classic chest pain. "Don't delay," she insists. "If you think something's wrong, come to the hospital." The 911 Rule Dr. Shewmake reinforces a critical safety message: never drive yourself to the hospital if you suspect a heart attack. Instead, call 911 immediately. Emergency medical services can begin life-saving treatment en route, significantly improving outcomes. This advice echoes the guidance of other cardiologists and represents a consensus among heart specialists. Women's Unique Risk Profile The conversation takes a deeper dive into the specific challenges women face regarding heart disease. Dr. Shewmake reveals that nearly 45 percent of women over age 20 have cardiovascular disease, yet less than half recognize this reality. Heart disease kills more women than all cancers—including breast cancer—combined, claiming one in three female lives. Moreover, women face distinct risk factors that men do not encounter. Hormonal changes during menopause, pregnancy-related complications, and autoimmune conditions all contribute to cardiovascular risk. Additionally, women often present with symptoms later in life but develop more complex disease. The medical community sometimes dismisses women's symptoms, compounding the problem. The Caregiver's Dilemma Janet raises an important point about women's tendency to prioritize others' health over their own. Women rush their husbands and children to the doctor at the first sign of trouble, yet they dismiss their own symptoms as minor inconveniences. Dr. Shewmake validates this observation and emphasizes the need to close the gap in how heart disease gets recognized and treated in women. She advocates for reframing primary care visits as self-care—an hour dedicated to one's own wellbeing. Using the airplane oxygen mask analogy, she reminds women that they must take care of themselves first to remain available for their families.  The Rising Threat to Young Adults Alarmingly, cardiovascular disease increasingly affects younger populations. Dr. Shewmake shares that her youngest female heart attack patient was 38, while her youngest male patient was just 30. Janet recounts the tragic story of her son's two high school friends—both in their early thirties—who died from heart attacks within three months. This trend stems from rising cardiovascular risk factors among young people, including diabetes, high blood pressure, and high cholesterol appearing at earlier ages. Additionally, genetics likely play a stronger role in these younger cases. Young adults often assume they're invincible, delaying treatment when symptoms appear. This dangerous mindset can prove fatal. Know Your Numbers Throughout the conversation, Dr. Shewmake repeatedly emphasizes the importance of knowing four critical numbers: cholesterol, blood pressure, BMI, and blood sugar. These metrics serve as early warning indicators for heart disease risk. She encourages everyone to discuss these numbers with their primary care physician and take action when they fall outside healthy ranges. Importantly, all these risk factors respond to treatment. Modern medicine offers excellent options for managing weight, cholesterol, and blood sugar. Some newer weight-loss medications not only help patients shed pounds and lower A1C levels but also provide cardiovascular benefits. These treatments represent powerful tools in the fight against heart disease. The Technology Trap When Janet mentions the false sense of security that fitness trackers provide, Dr. Shewmake agrees wholeheartedly. While devices like the Apple Watch offer some benefits, they cannot replace a comprehensive medical evaluation. No wearable technology can measure cholesterol levels, assess blood glucose, or provide the nuanced analysis that comes from a conversation with a healthcare provider. The Path Forward Dr. Shewmake welcomes referrals from primary care physicians when patients need specialized cardiovascular assessment. She sees many patients who request consultations even when their primary care doctors deem it unnecessary, and she views these visits as valuable opportunities for in-depth risk evaluation. Cardiologists can order specialized tests and provide individualized guidance that goes beyond population-level statistics. Breaking the Biggest Myth As the conversation concludes, Dr. Shewmake tackles the most dangerous misconception about heart disease: that it primarily affects men. While society recognizes heart attacks as the leading killer of men, this awareness doesn't extend to women. This gap in understanding costs lives. Her final message centers on empowerment. She urges everyone—especially women—to listen to their bodies, take symptoms seriously, and advocate for themselves when they know something feels wrong. Heart disease may be common, but it remains both preventable and treatable. Early action saves lives, and awareness changes everything. The Simple Truth Ultimately, Dr. Shewmake's message boils down to simple, actionable steps: eat well, move more, manage stress, get enough sleep, know your numbers, and remain tobacco-free. These everyday habits make a profound difference in cardiovascular health. Combined with regular medical care and self-advocacy, they form a powerful defense against America's leading cause of death. The conversation serves as both a wake-up call and a roadmap. Heart disease doesn't discriminate, but knowledge and action provide protection. By recognizing symptoms early, understanding personal risk factors, and prioritizing preventive care, individuals can take control of their heart health and potentially add years to their lives.

El síndrome climatérico es el conjunto de cambios que muchas mujeres viven cuando su cuerpo empieza a producir menos hormonas, especialmente estrógenos, durante la etapa previa y posterior a la menopausia. Aunque es un proceso natural, puede venir acompañado de molestias como bochornos, problemas para dormir, resequedad vaginal, cambios de humor o disminución del deseo sexual.  Uno de los tratamientos más conocidos es la terapia hormonal de remplazo, que puede ser muy efectiva para los bochornos intensos, la resequedad vaginal y para prevenir la pérdida de masa ósea en algunas mujeres. En este podcast de El Expresso de las 10 escucha los detalles con el Dr. Alberto Ballesteros, médico con especialidad en Ginecología y Obstetricia, especialidad en Biología de la Reproducción, doctorado en investigación y jefe de la División de Ginecología y Obstetricia del Hospital Civil Fray Antonio alcalde en Guadalajara. Académico de la Universidad de Guadalajara. 

Los desequilibrios que tienen un origen en la desconexión de la energía femenina y la naturaleza cíclica tienen un patrón hormonal en común y se llama dominancia estrogénica.En este episodio te explico la relación entre las hormonas del ciclo — que no son parte del sistema corporal sino quienes lo modifican — y el exceso de energía masculina con exigencia lineal. Y sobretodo, vamos a entender cómo es que a través de hábitos y herramientas especificas esos desequilibrios que parecen imposibles como el sindrome premenstrual, los dolores menstruales, el hambre emocional y los antojos dulces pueden ser revertidos.Para inscribirte en las masterclasses de marzo 2026 hacé click acá: www.wellnessrevolution.com.ar/ciclomasterclasses

In this final episode of the Progesterone Promise series, Dr. Brendan McCarthy, Chief Medical Officer of Protea Medical Center, breaks down one of the most misunderstood hormones in women's health: progesterone. Progesterone is not “good” or “bad.” It's contextual. In today's world of quick sound bites and social media medicine, hormones are often reduced to oversimplified claims like “progesterone fixes anxiety” or “progesterone causes breast cancer.” The truth? It depends on your body, your stress levels, your liver health, your inflammation, your delivery method, and whether you're using bioidentical progesterone or synthetic progestins.   Citations: 1. Oral Progesterone → First-Pass Metabolism & Allopregnanolone Claim: Oral micronized progesterone undergoes significant hepatic first-pass metabolism, increasing neuroactive metabolites (especially allopregnanolone), which positively modulate GABA-A receptors and produce sedative/anxiolytic effects. Core Evidence: Simon et al., 1993; de Lignières et al., 1995; Freeman et al., 1990 — Oral progesterone produces measurable neuroactive metabolites. Paul & Purdy, 1992; Rupprecht et al., 2001 — Allopregnanolone enhances GABA-A receptor activity. Supports: Sedation variability by route • Neurosteroid generation • GABA-A modulation 2. Sulfation vs 5α-Reduction → Opposing Neurologic Effects Claim: Progesterone metabolites can produce calming (5α-reduced) or excitatory (sulfated) neurologic effects depending on enzyme routing. Core Evidence: Majewska et al., 1990 — Pregnenolone sulfate negatively modulates GABA-A. Wu et al., 1991 — Sulfated neurosteroids enhance NMDA signaling. Schumacher et al., 2007; Reddy, 2010 — Pathway reviews of sulfation vs 5α-reduction. Supports: Reverse responding hypothesis • Divergent neurologic experiences • Enzyme-dependent effects 3. Stress & Enzyme Modulation Claim: Chronic stress alters HPA axis tone and hepatic enzyme expression, influencing steroid metabolism balance. Core Evidence: McEwen, 1998 — Allostatic load model. Charmandari et al., 2005 — Cortisol's systemic regulatory effects. Zanger & Schwab, 2013; Gibson & Skett, 2001 — Stress alters cytochrome P450 expression. Supports: Stress-biased metabolism • Context-dependent hormone response 4. Breast Tissue Signaling & Context Claim: Progesterone influences mammary differentiation and interacts with estrogen signaling in context-dependent ways. Core Evidence: Brisken & O'Malley, 2010 — Progesterone receptor biology in breast tissue. Beleut et al., 2010 — RANKL mediates progesterone-driven proliferation. Hofseth et al., 1999 — PR-ER signaling interaction. Stanczyk & Bhavnani, 2014 — Natural vs synthetic differences in breast effects. Supports: Lobuloalveolar differentiation • RANKL pathway • Context-dependent proliferation 5. Synthetic Progestins vs Bioidentical Progesterone Claim: Synthetic progestins differ structurally and bind off-target receptors, producing distinct tissue effects. Core Evidence: Stanczyk et al., 2013 — Receptor binding differences. Sitruk-Ware, 2004 — Biologic comparisons. Chlebowski et al., 2003 (WHI) — Breast cancer signal with CEE + MPA. Supports: Structural divergence • Receptor-level differences • WHI clarification 6. Route of Delivery Differences Claim: Oral, vaginal, transdermal, and sublingual progesterone produce distinct pharmacokinetic profiles and tissue targeting. Core Evidence: Simon, 1995 — Oral vs vaginal PK comparison. Cicinelli et al., 2000 — “First uterine pass effect.” Wren et al., 2003 — Route-dependent systemic levels. Supports: Uterine targeting • Neurosteroid variability • Sedation differences 7. Progesterone, PMS & Migraine Claim: Neurosteroid fluctuations influence GABAergic tone and may contribute to PMS and migraine susceptibility. Core Evidence: Backstrom et al., 2011 — Allopregnanolone fluctuations in PMS. Reddy & Rogawski, 2002 — Neurosteroids and seizure threshold. Martin & Behbehani, 2001 — Hormonal fluctuations and migraine. Supports: Luteal neurosteroid shifts • GABA instability • Migraine association   Dr. Brendan McCarthy is the founder and Chief Medical Officer of Protea Medical Center in Arizona. With over two decades of experience, he's helped thousands of patients navigate hormonal imbalances using bioidentical HRT, nutrition, and root-cause medicine. He's also taught and mentored other physicians on integrative approaches to hormone therapy, weight loss, fertility, and more. If you're ready to take your health seriously, this podcast is a great place to start.  

SummaryIn this conversation, Dr. Natalie discusses the challenges women face during midlife, particularly around wellness shaming, hormonal changes, and the pressure to conform to societal expectations. She emphasizes the importance of introspection and listening to one's body rather than relying solely on external validation and wellness culture. Dr. Natalie encourages women to embrace their individuality and build self-worth from within, acknowledging that it's okay to make mistakes along the way.TakeawaysThe exhaustion women feel in midlife is real and valid.Hormonal changes can create chaos in our bodies, similar to adolescence.Habit formation is challenging, especially when trying to adapt to new life phases.Introspection is crucial; we should listen to our bodies rather than just external advice.Wellness culture often exploits women's insecurities for profit.It's important to recognize that each woman's experience is unique.Building self-worth from within is essential for navigating midlife.It's okay to not have all the answers about what your body needs.Listening to your body can lead to better health outcomes than following external advice.You are not broken; you are evolving.Keywordsmidlife, wellness, hormones, introspection, self-worth, health, women, perimenopause, wellness culture, body positivitySound bites"The exhaustion is real.""It's okay to mess it up.""You are not broken."Chapters00:00 The Pressure of Midlife Wellness06:18 The Challenge of Habit Formation11:38 Critique of Wellness Culture21:00 Embracing Your Inner ExpertResources & Links: Connect with Dr. Natalie:Website ⁠https://LearnToLoveYourStory.com⁠⁠ ⁠Facebook ⁠facebook.com/learntoloveyourstory⁠Instagram⁠ instagram.com/dr.nataliemarr⁠Linked In ⁠linkedin.com/in/natalie-m-marr-psy-d-lp-6a9298147⁠Tik Tok ⁠tiktok.com/@doc.natalie⁠DISCLAIMER: The content in this podcast and video is not a replacement for therapy and is not clinical, medical, or mental health treatment. Dr. Natalie Marr is a Licensed Psychologist in the state of Minnesota. Her work with ⁠⁠(⁠⁠https://LearnToLoveYourStory.com⁠⁠⁠⁠⁠)⁠, ⁠(⁠⁠⁠⁠⁠https://NatalieMarrCounseling.com⁠⁠⁠⁠),⁠ and all affiliate social media entities is educational and coaching based ONLY. She IS NOT offering therapeutic services of any kind on these mediums. If you or someone you know is having a mental health crisis or having thoughts of suicide, please use the following crisis resources (this is not an exhaustive list of available resources):National Suicide Prevention Lifeline: ⁠⁠⁠⁠⁠⁠⁠⁠https://suicidepreventionlifeline.org⁠/⁠⁠⁠⁠⁠ CALL 988Crisis Text Line: ⁠⁠⁠⁠⁠⁠⁠⁠https://www.crisistextline.org/⁠⁠⁠⁠ ⁠⁠⁠⁠Text HOME to 741741

120. Microdosing for Midlife: Hormones, Perception, and Libido (Week 3)Exploring how menopause, perception shifts, and nervous system regulation intersect with midlife libido.Episode SummaryThis episode continues Week 3 of Microdosing for Midlife, April Pride's 12-part audio companion to her Substack series exploring microdosing through the lens of midlife transition.In this conversation, April examines one of the most quietly asked questions among women in perimenopause and menopause: can microdosing influence hormones or libido? Rather than positioning psilocybin as a hormonal intervention, she reframes the inquiry around perception, serotonin signaling, emotional regulation, and nervous system safety.The episode explores how estrogen fluctuations affect mood stability, why cortisol and stress patterns shape desire, and how subtle perceptual shifts—rather than dramatic sensations—may influence connection and intimacy. Through personal reflection and grounded science, April centers integration over hype.

Qué Temas Quieres Escuchar Toca y Hablemos. TE LEO.Hay decisiones de salud que generan más preguntas que respuestas. Cuando se habla de terapia hormonal, lo más común es escuchar que debe usarse por poco tiempo, en dosis mínimas o que, incluso, es mejor evitarla. Pero rara vez se explica el porqué.Esta falta de contexto deja a muchas personas con dudas reales sobre qué es lo más adecuado para su cuerpo y su bienestar a largo plazo. La conversación sobre hormonas y envejecimiento suele estar llena de mensajes contradictorios: lo que se repite, lo que se normaliza y aquello que casi nunca se aclara.En este episodio de “Cómo Curar” abrimos un espacio de reflexión para mirar estas decisiones con mayor conciencia y profundidad. Hablamos sobre el envejecimiento acelerado, los distintos métodos disponibles, y cuál podría ser la verdadera razón para considerar la terapia hormonal, abordando aspectos que pocas veces se explican con claridad y que merecen una mirada más informada.En este episodio abordamos:• El uso del apoyo hormonal y el tiempo recomendado.• La relación entre la suspensión de la terapia hormonal y el envejecimiento.• La controversia sobre tratar únicamente síntomas.• Los pellets o chips hormonales y otras alternativas.Disfruta de este episodio y muchos más contenidos en ComoCurar.com, en YouTube: Cocó March N.M.D., o en tu plataforma de podcast favorita, donde puedes escucharlos de forma gratuita.#CocoMarch #TipsCocoMarch #DoctoraCocoMarch #TerapiaHormonal #SaludHormonal #Hormonas #Envejecimiento #Estrogeno #Testosterona #ChipHormonal #PelletsHormonales #SaludYBienestar #SaludFemenina #SaludMasculina #EquilibrioHormonal #HormonasYSalud #DrAlbertoBali #Temporada4 #Episodio146 #ComoCurar

Okay ladies… this episode is for every woman who has looked in the mirror and thought:“What is happening to my body?”The weight that won't budge.The belly fat you've never had before.The exhaustion doesn't match your effort.The cravings, anxiety, bloating, low libido, and inflammation.Doing everything “right” — and nothing works.And then the quiet thought:Is this just aging… or is something actually wrong?Today I wanted a woman on the couch with me because there are things we just don't want to talk about with men. Things only another woman can understand, normalize, and validate.So I brought on Lauren Douglas, Family Nurse Practitioner and longevity-focused women's health provider at NuLevel Wellness. Lauren works with women in their 30s, 40s, and 50s who feel tired, inflamed, stuck, dismissed, and disconnected from their bodies — and helps them understand what's happening beneath the surface.This conversation covers perimenopause, menopause, hormones, metabolism, and aging — but it's also about identity, trust, and learning to support your body instead of fighting it.We talk about why women's bodies change after 35, why “healthy” stops working the same way, and why so many women blame themselves for shifts that are not their fault.This is not a quick-fix episode.It's a you're not broken episode.In this episode, we talk about:Why weight gain, belly fat, and insulin resistance show up in midlifeCravings, food noise, and nighttime hungerDeep exhaustion — even when you're eating well and exercisingMuscle loss and protecting strength as you ageGLP-1 medications and peptides — where they fit (and where they don't)Chronic inflammation, joint pain, and “mystery symptoms”Gut issues and bloating during hormone shiftsCortisol, stress weight, and wired-but-tired sleepLibido changes, dryness, and relationship impactHow to know whether you need hormones, peptides, GLP-1s, lifestyle shifts or none of the aboveMost importantly, we talk about agency — advocating for your health, asking better questions, and refusing to accept “this is just how it is.”This season isn't a decline.It's a transition.And transitions deserve education, compassion, and real support.Gentle content note:Hormonal changes, weight gain, sexual health, anxiety, inflammation, and medical dismissal are discussed.After listening:Notice where you've been blaming yourself instead of listening to your body.Ask: What if my body isn't failing — it's asking for something different?Start one conversation you've been avoiding.You're not crazy. You're not broken. You don't have to navigate this alone.Key moments from the episode:00:00 When You Don't Recognize Your Body03:20 Why These Changes Feel Sudden07:05 Early Signs of Perimenopause10:45 Why Weight Won't Budge14:40 Belly Fat & Insulin Resistance23:55 Hormones, BV & the Gut Link28:20 When Healthy Eating Stops Working37:10 GLP-1s for Women Explained45:55 Brain Fog & Hormones50:10 Libido & Dryness58:50 Inflammation & “Mystery” Symptoms1:03:20 Gut Issues & Hormones1:11:05 Choosing the Right Support PathConnect with Heidi:Website: https://heidipowell.net/Email: podcast@heidipowell.netInstagram: @realheidipowellFacebook: Heidi PowellYouTube: @RealHeidiPowellTrain with Heidi on her Show Up App: https://www.showupfit.app/Connect with Lauren Douglas:Website: https://nulevelwellness.com/Instagram: @laurendouglas_fnp (https://www.instagram.com/laurendouglas_fnp/)About Lauren Douglas:Lauren Douglas, FNP-C, is a Family Nurse Practitioner specializing in longevity, hormone, and metabolic health. After beginning in primary care, she shifted her focus to helping women navigate perimenopause and menopause with informed, compassionate support. As part of NuLevel Wellness, she helps patients restore energy, balance hormones, and improve vitality. Her approach bridges science and real life — so women feel informed, empowered, and supported.

If you have ever been told, “that's just perimenopause,” and felt like that explanation did not fully capture what you were experiencing, this episode offers a wider lens.Hormonal transitions in midlife are real. At the same time, they are rarely the only factor influencing symptoms like weight resistance, fatigue, digestive issues, mood changes, or feeling disconnected from your body. When everything gets labeled as perimenopause, important context can be missed.In this conversation, Janell Yule explores why so many women feel dismissed during this season of life and how focusing solely on hormones can prevent deeper understanding. She explains how the gut, nervous system, stress load, blood sugar regulation, and long-term depletion all interact with hormones and shape how the body adapts.This episode is not about denying perimenopause or minimizing hormonal shifts. It is about restoring clarity and personal power by recognizing patterns instead of chasing labels. When the full picture is considered, the body's symptoms often make a lot more sense.In this episode, Janell explores:• Why “it's all perimenopause” is an incomplete explanation• How age-based narratives can limit meaningful support• The relationship between hormones, gut health, stress, and blood sugar• What health debt is and how it accumulates over time• Why inflammation and depletion can mimic perimenopausal symptoms• The importance of pattern recognition over diagnosis alone• When deeper testing can provide insight and clarityIf you have ever felt brushed off or unheard when talking about your symptoms, this episode offers a more compassionate and comprehensive perspective.Health Disclaimer:This podcast is for educational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional regarding your personal health concerns.

This week on You Are Not Broken, I sit down with breast oncologist and historian Dr. Elizabeth Comen to talk about her powerful book All in Her Head and the long, complicated history of how women's health has been misunderstood, minimized, and medicalized. If you've ever been told your symptoms are anxiety… stress… hormones… or just part of being a woman — this episode is for you. We explore the historical roots of dismissal in women's healthcare and how those patterns still show up today, especially in cancer care. Dr. Comen walks us through how breast cancer treatment has evolved, what we've gotten right, what we've gotten wrong, and why quality of life must be part of the conversation — not an afterthought. We also talk about: Why women's pain has historically been labeled “hysteria” How medical bias still affects diagnosis and treatment The real tension between longevity and quality of life Hormonal therapies in breast cancer — and how nuance gets lost Why advocacy matters more than ever The double-edged sword of social media and AI in health information How understanding medical history helps us build better medicine today This episode isn't about blaming the past. It's about understanding it — so we stop repeating it. Because when women are dismissed, care suffers. And when women are informed, everything changes. If you care about evidence-based medicine, health equity, and empowering women with real information — this is a must-listen. Dr. Comen's IG Dr. Comen's Book Listen to my Tedx Talk: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Why we need adult sex ed⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Take my ⁠Adult Sex Ed Master Class:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠My Website⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Interested in my sexual health and hormone clinic? ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Waitlist is open⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Thanks to our sponsor ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Midi Women's Health⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Designed by midlife experts, delivered by experienced clinicians, covered by insurance.Midi is the first virtual care clinic made exclusively for women 40+. Evidence-based treatments. Personalized midlife care.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.joinmidi.com⁠ Learn more about your ad choices. Visit podcastchoices.com/adchoices

Conrad sat down with Michael Sipos, Florida Sea Grant Agent, to explore his journey from aquarium hobbyist to marine biologist—connecting his passion for science, sustainability, and the sea. From his master's research on hormonal induction spawning in ornamental fish, advancing sustainable aquaculture practices, to his current work addressing invasive species and fishing education in Florida, Mike blends research with real-world impact. Off the clock, he channels that same curiosity into spearfishing, among many other hobbies, combining skill, respect, and sustainability in everything he does. #FisheriesPodcast #SeaGrant #Spearfishing #Aquaculture #SustainableFishing #MarineScience #StayCurious  Takeaway: stay curious   “Get in touch with us! The Fisheries Podcast is on Facebook, X, Instagram, Threads, and Bluesky: @FisheriesPod  Become a Patron of the show: https://www.patreon.com/FisheriesPodcast Buy podcast shirts, hoodies, stickers, and more: https://teespring.com/stores/the-fisheries-podcast-fan-shop Thanks as always to Andrew Gialanella for the fantastic intro/outro music. The Fisheries Podcast is a completely independent podcast, not affiliated with a larger organization or entity. Reference to any specific product or entity does not constitute an endorsement or recommendation by the podcast. The views expressed by guests are their own and their appearance on the program does not imply an endorsement of them or any entity they represent. Views and opinions expressed by the hosts are those of that individual and do not necessarily reflect the view of any entity with those individuals are affiliated in other capacities (such as employers).”

The power of movement & defining the love you want: movement choirs; nervous system regulation & a ten-step path to figure out the type of love you deserve On this episode of The Lisa Burke Show, dancers Veronique Scheer and Gabrielle Staiger talk about how the body stores emotions. Mentor Rick Serrano walks through a simple checklist to define a partner that matches your life goals and one deserving of you. Traumatic Injury to Identity Shift, Education and Trauma-Healing workshops Veronique Scheer, founder of Very Unique Yoga, was a professional musical theatre performer living her dream life in Barcelona as a young adult. This dream was abruptly halted by a devastating motorbike accident at 21. Through years of rehabilitation, a law degree (plan B) and reinvention, Veronique turned to yoga, pilates and trauma-healing practice. She realised that movement could me more than performance or aesthetics; it could be a tool for nervous system regulation, trauma healing and identity reconstruction. “The nervous system governs how we experience life.” Today, Veronique's work blends movement science, hormonal literacy and nervous system education into a holistic approach, particularly supporting women navigating stress, burnout, postnatal recovery and life transitions. She distinguishes between nervous system regulation and long‑term training, emphasising that our reactions often arise from stored patterns in the nervous system long before cognition catches up. Co-regulation in couples Veronique also conducts couples yoga classes, and can see how their nervous systems sync in a calming or dysregulated way. Through workshops and couple classes, she sees first‑hand how movement can reveal communication patterns, power struggles, people‑pleasing and sexual disconnect. These workshops also show how playful, shared movement can help partners remember why they fell in love. Using practices such as AcroYoga, she watches trust, control and surrender play out physically: some couples re‑discover laughter and tenderness; others confront that their relationship may actually be over. Veronique's upcoming digital academy and app (launching 2026) brings together: - Nervous system regulation - Hormonal health education - Trauma-aware movement - Conscious relationship development

Why does sex often become uncomfortable, pressured, or disconnected in midlife — even in loving relationships?Book a Discovery Call for Relationship Renovation CoachingIn this episode, EJ and Tarah are joined by Dr. Maria Sophocles, board-certified gynecologist and national menopause expert, to explore what she calls The Bedroom Gap — the growing difference in expectations, desire, and physical experience that many couples face as they age.They discuss why so many women feel broken or ashamed when intimacy changes, why couples rarely talk openly about it, and how hormonal shifts, cultural messaging, and outdated definitions of sex create disconnection.Dr. Sophocles shares three essential steps to closing the gap:• Know thyself — understanding your body, hormones, and pleasure• Communicate — removing shame and learning to talk honestly about sex• Redefine sex — shifting from performance and obligation to connection and pleasureYou will also hear about:• How perimenopause and menopause impact desire and comfort• Why pain during sex often leads to avoidance and fear• How shame silently fuels disconnection• Why redefining sex beyond penetration changes everything• The difference between obligation-based sex and connection-based intimacy• How couples can rebuild trust after long periods of distanceThis episode is especially helpful if:• Intimacy feels tense, painful, or avoided• One partner feels rejected while the other feels pressured• Hormonal changes have shifted desire• You miss feeling close but do not know how to start again• Shame makes it hard to talk about sexThis is an honest, hopeful conversation about sexual health, emotional safety, and rediscovering pleasure in long-term relationships.Dr. Sophocles links below: The Bedroom Gap: Rewrite the Rules and Roles of Sex in Midlifehttps://mariasophoclesmd.com/Learn More About Relationship RenovationOrder Relationship Renovation at Home Manual from AmazonJoin Our Patreon CommunitySupport this podcast at — https://redcircle.com/he-said-she-said/donationsAdvertising Inquiries: https://redcircle.com/brands

Join Dr. Jason Fung and Dr. Robert Kiltz to uncover the truth about insulin resistance, fasting, and weight loss. Learn why calorie counting fails and how to reverse type 2 diabetes naturally.Get your copy of Dr. Jason Fung's new book: The Hunger Code: Resetting Your Body's Fat Thermostat in the Age of Ultra-Processed Food: https://a.co/d/09sTQ2yDSign up now for a Intro Coaching call with one of our certified Kiltz Health Coaches: https://calendly.com/d/cxdf-5ft-z2k/kiltz-health-one-on-one-coaching?month=2026-02

Pelvic pain, bladder symptoms, and sexual health concerns are incredibly common in people with Ehlers-Danlos Syndromes, yet they're often misunderstood, dismissed, or treated in isolation. In this episode of Bendy Bodies, Dr. Linda Bluestein is joined by Dr. Rachel Rubin, a board-certified urologist and nationally recognized leader in sexual medicine, to unpack why connective tissue disorders, mast cell activation, dysautonomia, and hormonal shifts so often collide in the pelvis. Together, they explore why bladder symptoms can occur without infection, why pelvic floor therapy alone may not be enough, and how hormones influence tissue health, inflammation, and pain. The conversation dives into underrecognized drivers of symptoms, like vestibular pain, nerve involvement, mast cell activity, and hormonal suppression from birth control, while also addressing why many patients are left searching for answers for years. Dr. Rubin explains why sexual health is inseparable from overall health and how multidisciplinary, patient-centered care can dramatically improve quality of life. For anyone living with a connective tissue disorder who has been told “everything looks normal” despite ongoing pelvic or bladder symptoms, this episode offers clarity, validation, and a new framework for understanding what may actually be happening. Takeaways: Pelvic and bladder symptoms in EDS are rarely caused by just one issue, they often involve hormones, nerves, mast cells, and musculoskeletal factors together. Pain with tampons, sex, or sitting is not normal, even if exams and tests appear normal. Hormonal changes and suppression can significantly affect pelvic tissue health, contributing to pain and urinary symptoms. Pelvic floor therapy helps many patients, but not all, especially when underlying tissue or hormonal issues go unaddressed. Sexual health is a quality-of-life issue, not a luxury, and deserves serious medical attention in hypermobility care. Find the episode transcript here. Want more Dr. Rachel Rubin? Instagram: @drrachelrubin YouTube: https://www.youtube.com/c/DrRachelRubin Want more Dr. Linda Bluestein, MD? Website: https://www.hypermobilitymd.com/ YouTube: https://www.youtube.com/@bendybodiespodcast Instagram: ⁠⁠⁠⁠https://www.instagram.com/hypermobilitymd/⁠⁠⁠⁠ Facebook: ⁠⁠⁠⁠https://www.facebook.com/BendyBodiesPodcast⁠⁠⁠⁠ X: ⁠⁠⁠⁠https://twitter.com/BluesteinLinda⁠⁠⁠⁠ LinkedIn: ⁠⁠⁠⁠https://www.linkedin.com/in/hypermobilitymd/⁠⁠⁠⁠ Newsletter: ⁠⁠⁠⁠https://hypermobilitymd.substack.com/ Shop my Amazon store ⁠⁠⁠ https://www.amazon.com/shop/hypermobilitymd Dr. Bluestein's Recommended Herbs, Supplements and Care Necessities: https://us.fullscript.com/welcome/hypermobilitymd/store-start Want to learn more about the UVA EDS Center? For Appointments and Questions: RUVAEDSCenter@uvahealth.org UVA EDS: https://www.uvahealth.com/healthy-practice/advancing-care-through-ehlers-danlos-clinic UVA EDS FAQ: https://www.uvahealth.com/support/eds/faq UVA Pediatric Integrative Medicine: https://childrens.uvahealth.com/specialties/integrative-health Thank YOU so much for tuning in. We hope you found this episode informative, inspiring, useful, validating, and enjoyable. Join us on the next episode for YOUR time to level up your knowledge about hypermobility disorders and the people who have them. Join YOUR Bendy Bodies community at ⁠⁠https://www.bendybodiespodcast.com/⁠⁠. YOUR bendy body is our highest priority!⁠⁠ Learn more about Human Content at ⁠⁠⁠http://www.human-content.com⁠⁠⁠ Podcast Advertising/Business Inquiries: ⁠⁠⁠sales@human-content.com⁠⁠⁠ Part of the Human Content Podcast Network FTC: This video is not sponsored. Links are commissionable, meaning I may earn commission from purchases made through links Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode, Dana Irvine shares essential insights on common mistakes women over 40 make regarding breast health and practical ways to support and improve it. Whether you're new to self-care or looking to refine your routine, these tips are vital for maintaining health and confidence.The importance of regular breast health monitoring beyond annual mammogramsChallenging normalization of breast pain, tenderness, and congestionOvercoming fear and avoidance of self-breast examsThe impact of detoxing too aggressively on breast healthThe critical role of lymphatic health in overall breast wellnessHow supporting hormones, liver, and gut enhances breast healthEffects of chronic stress on breast tissue and overall wellbeingThe importance of proactive, holistic self-care over reactive health measuresResources & Links:Touch Your Tatta's ProgramFive Minutes to Wellness GuideDr. Perry Nicholson - Lymphatic ActivistBreast Health Support & Self-ExamsConnect with Dana Irvine:InstagramWebsiteIf you're over 40 and feeling:• Tired but wired • Bloated or inflamed • Hormonal and frustrated • Concerned about breast health • Unsure what testing you truly needYou don't need another quick fix. You need clarity.The Wise Divine Women Health Clarity Call is your 1:1 strategy session to uncover root causes and map out your next best steps — whether that's functional testing, thermography, nutrition coaching, or hormone support.

In this episode of the progesterone series, Dr. Brendan McCarthy — Chief Medical Officer of Protea Medical Center in Tempe, Arizona — explores the often misunderstood relationship between progesterone, estrogen, and breast health. For decades, women have been taught to fear their breasts and fear hormones. While awareness matters, fear is disempowering — and it has left many women confused about what's actually happening in their bodies. In this episode, we discuss: Why breast tissue is dynamic, not static How estrogen stimulates growth and progesterone restores balance The role of progesterone in breast tissue maturation and architecture Why dense or fibrocystic breasts often reflect unopposed estrogen How restoring ovulation and progesterone can reduce breast pain and density in some women The difference between natural progesterone vs synthetic progestins Where the fear around progesterone and breast cancer really came from Progesterone is not something to fear — it is a hormone of organization, balance, and maturation. Understanding how it works allows women to approach breast health with clarity instead of anxiety.

Pelvic pain, bladder symptoms, and sexual health concerns are incredibly common in people with Ehlers-Danlos Syndromes, yet they're often misunderstood, dismissed, or treated in isolation. In this episode of Bendy Bodies, Dr. Linda Bluestein is joined by Dr. Rachel Rubin, a board-certified urologist and nationally recognized leader in sexual medicine, to unpack why connective tissue disorders, mast cell activation, dysautonomia, and hormonal shifts so often collide in the pelvis. Together, they explore why bladder symptoms can occur without infection, why pelvic floor therapy alone may not be enough, and how hormones influence tissue health, inflammation, and pain. The conversation dives into underrecognized drivers of symptoms, like vestibular pain, nerve involvement, mast cell activity, and hormonal suppression from birth control, while also addressing why many patients are left searching for answers for years. Dr. Rubin explains why sexual health is inseparable from overall health and how multidisciplinary, patient-centered care can dramatically improve quality of life. For anyone living with a connective tissue disorder who has been told “everything looks normal” despite ongoing pelvic or bladder symptoms, this episode offers clarity, validation, and a new framework for understanding what may actually be happening. Takeaways: Pelvic and bladder symptoms in EDS are rarely caused by just one issue, they often involve hormones, nerves, mast cells, and musculoskeletal factors together. Pain with tampons, sex, or sitting is not normal, even if exams and tests appear normal. Hormonal changes and suppression can significantly affect pelvic tissue health, contributing to pain and urinary symptoms. Pelvic floor therapy helps many patients, but not all, especially when underlying tissue or hormonal issues go unaddressed. Sexual health is a quality-of-life issue, not a luxury, and deserves serious medical attention in hypermobility care. Find the episode transcript here. Want more Dr. Rachel Rubin? Instagram: @drrachelrubin YouTube: https://www.youtube.com/c/DrRachelRubin Want more Dr. Linda Bluestein, MD? Website: https://www.hypermobilitymd.com/ YouTube: https://www.youtube.com/@bendybodiespodcast Instagram: ⁠⁠⁠⁠https://www.instagram.com/hypermobilitymd/⁠⁠⁠⁠ Facebook: ⁠⁠⁠⁠https://www.facebook.com/BendyBodiesPodcast⁠⁠⁠⁠ X: ⁠⁠⁠⁠https://twitter.com/BluesteinLinda⁠⁠⁠⁠ LinkedIn: ⁠⁠⁠⁠https://www.linkedin.com/in/hypermobilitymd/⁠⁠⁠⁠ Newsletter: ⁠⁠⁠⁠https://hypermobilitymd.substack.com/ Shop my Amazon store ⁠⁠⁠ https://www.amazon.com/shop/hypermobilitymd Dr. Bluestein's Recommended Herbs, Supplements and Care Necessities: https://us.fullscript.com/welcome/hypermobilitymd/store-start Want to learn more about the UVA EDS Center? For Appointments and Questions: RUVAEDSCenter@uvahealth.org UVA EDS: https://www.uvahealth.com/healthy-practice/advancing-care-through-ehlers-danlos-clinic UVA EDS FAQ: https://www.uvahealth.com/support/eds/faq UVA Pediatric Integrative Medicine: https://childrens.uvahealth.com/specialties/integrative-health Thank YOU so much for tuning in. We hope you found this episode informative, inspiring, useful, validating, and enjoyable. Join us on the next episode for YOUR time to level up your knowledge about hypermobility disorders and the people who have them. Join YOUR Bendy Bodies community at ⁠⁠https://www.bendybodiespodcast.com/⁠⁠. YOUR bendy body is our highest priority!⁠⁠ Learn more about Human Content at ⁠⁠⁠http://www.human-content.com⁠⁠⁠ Podcast Advertising/Business Inquiries: ⁠⁠⁠sales@human-content.com⁠⁠⁠ Part of the Human Content Podcast Network FTC: This video is not sponsored. Links are commissionable, meaning I may earn commission from purchases made through links Learn more about your ad choices. Visit megaphone.fm/adchoices

Host Dr. Davide Soldato and guests Dr. David Einstein and Dr. Ravi Madan discuss JCO article, "National Cancer Institute's Working Group on Biochemically Recurrent Prostate Cancer: Clinical Trial Design Considerations," underscoring the need for a consensus on clinical trial designs implementing novel endpoints in this population, the importance of PSA doubling time as a prognostic factor and with an emphasis on treatment de-escalation to limit toxicity and improve patient outcomes. TRANSCRIPT The disclosures for guests on this podcast can be found in the show notes. Davide Soldato: Hello and welcome to JCO After Hours, the podcast where we sit down with authors from some of the latest articles published in the Journal of Clinical Oncology. I am your host, Dr. Davide Soldato, medical oncologist at Ospedale San Martino in Genoa, Italy. Today, we are joined by JCO authors Dr. David Einstein and Dr. Ravi Madan. Dr. Einstein is a medical oncologist specializing in genitourinary malignancy working at Beth Israel Deaconess Medical Center, part of the DFCI Cancer Center, and an assistant professor at Harvard Medical School. Dr. Madan is a senior clinician at the National Cancer Institute (NCI), where he focuses on conducting clinical research in prostate cancer, particularly in the field of immunotherapy. Today, we will be discussing the article titled, "National Cancer Institute's Working Group on Biochemically Recurrent Prostate Cancer: Clinical Trial Design Considerations." So, thank you for speaking with us, Dr. Einstein and Dr. Madan. David Einstein: Thanks for having us. This is a great pleasure. Ravi Madan: Appreciate being here. Davide Soldato: So, I just want to start from a very wide angle. And the main question is why did you feel that there was the need to convey a consensus and a working group to talk about this specific topic: biochemically recurrent prostate cancer? What has been the change in current clinical practice and in the trial design that we are seeing nowadays? And so, why was it necessary to convey such a consensus and provide considerations on novel clinical trials? David Einstein: Yeah, so I think it's very interesting, this disease state of biochemically recurrent prostate cancer. It's very different from other disease states in prostate cancer, and we felt that there was a real need to define those differences in clinical trials. Years ago, metastatic castration-resistant prostate cancer was the primary disease state that was explored, and over time, a lot of things shifted earlier to metastatic disease defined on a CAT scan and bone scan to an earlier disease state of metastatic castration-sensitive prostate cancer. And the clinical trial principles from late-stage could be applied to MCSPC as well. However, BCR is very different because the patients are very different. And for those reasons, there are unique considerations, especially in terms of toxicity and treatment intensity, that should be applied to biochemically recurrent prostate cancer as opposed to just using the principles that are used in other disease states. And for that reason, we thought it was very important to delineate some of these considerations in this paper with a group of experts. Davide Soldato: Thanks so much. So, one of the main changes that have been applied in recent years in clinical practice when looking at biochemically recurrent prostate cancer is the use of molecular imaging and particularly of PSMA PET. So, first of all, just a quick question: was the topic of the consensus related on which threshold of PSA to use to order a PET scan to evaluate this kind of patient? David Einstein: Yeah, thanks for that question. It's a super important one. The brief answer is that no, we did not address questions about exactly when clinicians would decide to order scans. We were more concerned with the results of those scans in how you define different disease states. But I think as a broader question, I think a lot of folks feel that finding things on a scan equates that with what we used to find on conventional scans. And fundamentally, we actually sought to redefine that disease space as something that's not equivalent to metastatic disease, and rather coined the term "PSMA-positive BCR" to indicate that traditional BCR prognostic criteria and factors still apply, and that these patients have a distinct natural history from those with more advanced metastatic disease. Ravi Madan: And if I may just add that the National Cancer Institute is running a trial where we're prospectively monitoring PSMA-positive BCR patients. And that data is clearly showing that, much like what we knew about BCR a decade ago, PSMA findings in BCR patients do not change the fact that overall, BCR is an indolent disease state. And the findings, which are usually comprised of five- to seven-millimeter lymph nodes, do not endanger patients or require immediate therapy. And so, while PSMA is a tool that we can be using in this disease state, it doesn't really change the principal approach to how we should manage these patients. And as Dr. Einstein alluded to, there is a drive to create a false equivalency between PSMA-positive BCR and metastatic castration-sensitive prostate cancer, but that is not supported by the data we're accumulating or any of the clinical data as it exists. Davide Soldato: One thing that it's very important and you mentioned in your answer to my question was actually the role of PET scan and conventional imaging, so CAT scan and bone scan that we have used for years to stage patients with metastatic prostate cancer. And you mentioned that there is a distinction among patients who have a positive PET scan and a BCR, and patients who have a positive conventional imaging. And yet, we know that sometimes the findings of the PET scan are not always so clear to interpret. So, I just wanted to understand if the consensus reached an agreement as to when to use conventional imaging to potentially resolve some findings that we have on PET scan among thess patients with BCR? David Einstein: Yeah, I think there's a number of questions actually buried within that question. One of which is: does PSMA PET result in false positives? And the answer has definitely been yes. There's a known issue with false-positive rib lesions. And so, first and foremost, we need to be very careful in calling what truly is suspicious disease and what might actually not be cancer or might be something that is totally separate. So I think that's the first part of the answer to that question. The second is to what extent do we need to use paired PET and conventional imaging to define this disease state? In other words, do you have to have positive findings on one and negative findings on the other in order to enter this definition? The challenge there, as we discussed, is that logistically, oftentimes it's hard to get patients to do multiple sets of scans to actually create that definition. Sometimes it's difficult to get insurers to pay for such scans. And finally, it's hard to sometimes blind radiologists to the results of one scan in reading the other. So, we did have some deliberations about to what extent you could use some of the CAT scan portion of a PSMA PET in order to at least partially define that. We also talked about using bone scans to confirm any bone findings seen on PET. But I think another important part of this is not just the baseline imaging, but also what's going to be done serially on a study in order to define responses and progression. And that's sort of a whole separate conversation about to what extent you can interpret changes in serial PET. Ravi Madan: And just to pick up on the key factor here, I think that the PSMA PET in BCR is pretty good at defining lymph node disease, and that's actually predominantly 80 to 90 percent of the disease seen on these findings. It might be pretty good at also defining other soft tissue findings. The real issues come to bone findings. And one thing the group did not feel was appropriate was to just define only PSMA-positive bone findings confirmed on a CT bone window. There's not really great data on that, but the working group felt that, when in the rare situation, because it is relatively rare, a PSMA-positive finding is in a bone, a bone scan should be done. And it's worth noting that Phu Tran, who is a co-author and a co-leader of this working group, his group has already defined that underlying genomics of conventionally based lesions, such as bone scan, are more aggressive than findings on next-gen imaging, such as PSMA. So, there is also a genomic underlying rationale for defining the difference between what is seen on a PET scan in a bone and what is seen on a bone scan. Davide Soldato: Coming back to this issue of PET PSMA sometimes identifying very small lesions where we don't see any kind of correlates on conventional imaging or where we see only very little alteration on the bone scan or in the CT scan, was there any role that was imagined, for example, for MRI to distinguish this type of findings on the PET scan? Ravi Madan: So, I think that, again, what can be identified on a PSMA frequently cannot be seen on conventional imaging. We didn't feel that it was a requirement to get an MRI or a CT to necessarily confirm the PSMA findings. I think that generally, we have to realize that in this disease state, that questionable lesions are going to be seen on any imaging, including PSMA. We've actually probably put way too much faith in PSMA findings thus far, as Dr. Einstein alluded to with some of the false positives we're seeing. So, I think that these false positives are going to have to be baked into trials. And in terms of clinical practice, it highlights the need to again, not overreact to everything we see and not necessarily need to biopsy everything and put patients' health in jeopardy to delineate a disease that's indolent anyway. Davide Soldato: Thanks so much. That was very clear. So, basically, the main driver was really also the data showing that if we have a BCR, so a patient with a biochemically recurrent disease that is positive on the conventional imaging, this is usually associated with a different aggressiveness of the disease. But coming back to a comment that you made before, Dr. Madan, you said that even if we talk about PSMA-positive BCR, we are still talking about BCR and the same criteria should apply. So, what we have used for years in this space to actually try to stratify the prognosis of patients is the PSA doubling time, so how quickly the PSA rises over time. So, coming back to that comment, was the consensus on the PSA doubling time basically retained as what we were using before, so defining patients with a doubling time less than 12 months, 10 months, 9 months, as patients with a higher risk of progressing in terms of developing metastatic disease? Ravi Madan: Yes, so that's a very important point. And the working group defined high-risk BCR as a PSA doubling time less than six months. And this really comes from Johns Hopkins historical data, which shows that if your doubling time is three months or less, there's about a 67 percent chance of metastasis at five years. If it's between three and six months, it's 50 percent. And if it's over six months, if it's between six and nine months, it's roughly only 27 percent. There are trials that are accruing with eligibility criteria that they may describe as high-risk that are beyond six months, but the data as really it's been defined in the literature highlights that truly high-risk BCR is less than six months. And the working group had a consensus on that opinion, and that was our recommendation. David Einstein: And I think an important follow-on to that is that's regardless of PET findings, right? And so, we present a couple of case studies of patients with positive PET findings who have a long doubling time, in whom the disease is in fact indolent, as you would have expected from a traditional BCR prognostic standpoint. Obviously, there are patients in whom they have fast doubling times, and even if they do not have PET findings, that doesn't make them not high-risk. Ravi Madan: And just to follow up that point, I will let you know a little bit of a free preview that my colleague Melissa Abel from the NCI will be presenting PSMA findings in the context of PSA doubling time at ASCO GU if that data is accepted. Davide Soldato: Looking forward for those data because I think that they're going to clarify a lot of the findings that we have in this specific population. And coming back to one of the points that we made before, so PET PSMA has a very high ability to discriminate also a very low burden of disease, which we currently refer to as oligometastatic biochemically recurrent prostate cancer, which is not entirely defined as an entity. But what we are seeing both in some clinical trials, which use mainly conventional imaging, but also what we're starting to see in clinical practice, is that frequently we use the metastasis-directed therapy to treat these patients. So, just a little bit of a comment on the use of this type of strategy in clinical practice and if the panel thought of including this as, for example, a stratification criteria or mandated in the design of novel clinical trials in the field of BCR? David Einstein: Yeah, I think that's an incredibly important point. You know, fundamentally, there's a lot of heterogeneity in practice where some folks are using local salvage approaches, some are using systemic therapies, in some cases surveillance may be reasonable, or some combination of these different strategies. We certainly have phase two data from multiple trials suggesting that met-directed therapy may help buy patients time off of treatment until subsequent treatments are started. And that in and of itself may be an important goal that we can come back to in discussing novel endpoints. I think what our panel acknowledged was that, in some sense, the clinical practice has gotten even farther ahead than where the data are, and this is being offered pretty routinely to patients in practice. And so, what became clear was that we, in developing clinical trials, cannot forbid investigators from doing something that would be within their usual standard of care, even if it might not be supported by the most robust data. But at minimum, it definitely should be used as a stratification factor, or in some trial designs, you can do met-directed therapy after a primary endpoint is assessed. And that offers a compromise between testing, say, the effect of a systemic therapy but also not excluding patients and investigators from doing what they would have done had they not been on a study. Ravi Madan: And I would just like to follow up your phrasing in the question of "oligometastatic prostate cancer." We have a figure in the paper and it highlights the fact that, unfortunately, that term in prostate cancer is imaging agnostic. And we've already discussed in this podcast, as well as in the paper, that imaging used to define a metastatic lesion, whether it's PSMA or conventional imaging, carries with it a different clinical weight and a different prognosis. So, we feel in the working group, that the correct term for this disease state of PSMA-positive BCR is just that: PSMA-positive BCR. We also have to realize that when we talk about oligometastatic disease, while it's imaging agnostic, it seems to be numerically based, whether it's five or three or 10 depending on the trial. But PSMA-positive BCR does not have a limit in terms of the number of lesions. And so again, we just feel that there is an important need to delineate what we're seeing in this disease state, which again is PSMA-positive BCR, and that should be differentiated frankly from oligometastatic disease defined on other imaging platforms. David Einstein: Right, and that also makes clear that patients can have polyfocal disease on PET that still is not what we would consider metastatic, but goes beyond the traditional definition of oligometastatic. So, in other words, just because someone has PET-detected disease only, that does not automatically equate with oligometastatic. Davide Soldato: Thanks so much. So, you were speaking a little bit, Dr. Einstein, about the different types of treatment that we can propose or not propose to this patient because you mentioned, for example, that in clinical practice MDT, so metastasis-directed therapy, is becoming more and more used. For these patients, we can potentially use systemic treatments, which include androgen deprivation therapy, which can be given continuously or in an intermittent fashion. And recently, we can also use novel systemic therapies, for example, enzalutamide, to treat this type of patient. So, given that the point of the consensus was really to provide consideration for novel clinical trials in this space, what was the opinion on the panel regarding the control arm? So, if we're looking at a novel therapy in the BCR space, does the control arm need to include a therapy or not? And if so, which therapy? David Einstein: Yeah, this is a super important question and one that's subject to a lot of discussion, especially in light of recent data from EMBARK. What we came to a consensus around was the fact that neither MDT nor systemic therapy should be required as a control arm on BCR trials. And we can talk about a number of reasons for that. There's also the pragmatics of what investigators might actually accrue patients to and what they would consider their standard of care, and that's important to factor in, too. I think that one of the major goals of our working group was outlining what kinds of trials we would like to see in the future and where the limitations of the current data stand. For example, EMBARK proposes a strategy of a single treatment discontinuation and resumption at a predefined threshold indefinitely. That's probably not how most people are practicing. Most folks are probably using some version of intermittent therapy as they would have before this trial, but we actually don't have any data supporting that. Moreover, we don't have data comparing different intermittent strategies to one another. We don't know what the right thresholds are, we don't know how much time we buy patients off treatment, and we don't know to what extent MDT modifies that. And so, those are all really important questions to be asking in future versions of these trials. I'd say my second point would be that a lot of drug development is happening with novel therapies that are not hormonal, trying to bring them into this space. And when you think about trying to compare one of those types of therapies to a hormonal therapy on short-term endpoints, the hormonal therapy is always going to win. Hormonal therapy is almost universally effective, it will bring down PSAs, and it will prolong, quote-unquote, "progression." The downside of that is that hormonal therapy doesn't actually modify the disease, it suppresses it, and it tends to have fairly transient effects once you remove it. And so, part of our goal was in trying to figure out some novel endpoints that would allow these novel types of therapies to be examined head-to-head against a more traditional type of hormonal therapy and have some measurement of some of the more long-term impacts. Davide Soldato: So, jumping right into the endpoints, because this is a very relevant and I think very well-constructed part of the paper that you published. Because in the past we have used some of these endpoints, for example, metastasis-free survival, as potentially a proxy for long-term outcomes. But is this the right endpoint to be using right now, especially considering that frequently this outcome is measured using conventional imaging, but we are including in these trials patients who are actually negative on conventional imaging but have a positive PSMA when they enter this type of trial? David Einstein: Yeah, there's a number of challenges with those types of endpoints. One of which is, as you say, we're changing the goalposts a little bit on how we're calling progression. We still don't exactly understand what progression on PET means, and so that's something that is challenging. That said, we're also cognizant of the fact that many times investigators are likely to get PET scans in the setting of rising PSA, and that's going to affect any endpoint that relies purely on conventional imaging. So, there's some tension there between these two different sets of goalposts. One thing that we emphasize is that not only are there some challenges in defining those, but also there're challenges in what matters to a patient. So, if a progression event occurs in the form of a single lesion on a PET scan or even a conventional image, that might be relevant for a clinical trial but might be less relevant for a patient. In other words, that's something that, in the real world, an investigator might use serial rounds of metastasis-directed therapy or intermittent therapy to treat in a way that doesn't have any clinical consequences for the patient necessarily. In other words, they're asymptomatic, it's not the equivalent of a metastatic castration-resistant disease progressing. And so, we also need to be cognizant of the fact that if we choose a single endpoint like PFS, that there's going to be many different versions of progression, some of which probably matter clinically more than others, and some of which are more salvageable by local therapies than others. Ravi Madan: So I think the working group really thoughtfully looked at the different options and underscored perhaps strengths and weaknesses, and I think that's presented as you mentioned in the paper. But I think it's also going to depend on the modality, the approach of the therapeutic intervention. In some cases if it's hormone-based, then maybe PSA is providing some early metrics, maybe metastasis-free survival is more relevant in a continuous therapy, but intermittent therapies might have a different approach. There's emerging immunotherapy strategies, radiopharmaceutical strategies, they might have some more novel strategies as well. I think we have to be open-minded here, but we also have to be very clear: we do not know what progression is on a PSMA scan. Just new lesions may not carry the clinical significance that we think, and we may not know what threshold that ultimately becomes clinically relevant is. So, I do think that there was some caution issued by the working group about using PSMA as an endpoint because we still do not have the data to understand what that modality is telling us. Again, I'm optimistic that the National Cancer Institute's prospective data set that we've been collecting, which has over 130 patients now, will provide some insights in the months and years ahead. Davide Soldato: So, just to ask the question very abruptly, what would you feel like the best endpoint for this type of trials is? I understand that is a little bit related to the type of treatments that we're going to use, whether it's intermittent, whether it's continuous, but do we have something that can encapsulate all of the discussion that we have up until this point? David Einstein: Yeah, so that's a perfect segue to the idea of novel endpoints, which we feel are very important to develop in these novel disease spaces. So, one thing that we discussed was an endpoint called treatment-free survival, which conceptually you can think of as exactly what it sounds like, but statistically you actually have to do some work to get there. And so essentially, you imagine a series of Kaplan-Meier curves overlaid: one about overall survival, one time to next therapy, one time on initial therapy. You can actually then take the area under those curves or between those curves and essentially sum it up using restricted mean survival time analysis. And that can give you a guide about the longitudinal experience of a patient: time spent on treatment versus off treatment; time spent with toxicity versus without toxicity. And importantly, each one of those time-to-event metrics can be adjusted depending on exactly what the protocol is and what is allowed or not allowed and what's prespecified as far as initiation of subsequent therapies. So, we felt that this was a really important endpoint to develop in this disease space because it can really capture that longitudinal aspect. It can really reward treatments that are effective in getting durable responses and getting patients off of therapy, because unfortunately, PFS-based endpoints generally reward more or longer systemic therapy versus shorter or no systemic therapy, and that's sort of an artificial bias in the way those endpoints are constructed. So, I think that there are challenges of course in implementing any new endpoint, and some of the things that are really critical are collecting data about toxicity and about subsequent therapies beyond what a typical trial might collect. But I think in this kind of disease space, that longitudinal aspect is critical because these are really patients who are going to be going through multiple rounds of therapy, going to be going on and off treatments, they're going to be using combinations of local and systemic therapies. And so, any one single endpoint is going to be limited, but I think that really highlights the limitations of using PFS-based endpoints in this space. Ravi Madan: I also think that in the concept of treatment-free survival lies one of the more powerful and, honestly, I was surprised by this, that it was so universally accepted, recommendations from the committee. And that was that the general approach to trials in this space should be a de-escalation of the EMBARK strategy as it's laid out with relatively continuous therapy with one pause. And so, I think again, buried in all of this highlights the need for novel endpoints like treatment-free survival. We get to the fact that these are patients who are not at near-term clinical risk from symptoms of their disease, so de-escalating therapies does not put them at risk. And if you look at, for example, lower-volume metastatic castration-sensitive prostate cancer, it's become realized that we need to de-escalate, and there are now trials being done to look at that. Historically, we know that BCR is an indolent disease process for the vast majority of patients who are not at near-term risk from clinical deterioration. So, therefore, we shouldn't wait a decade into abundant BCR trials to de-escalate. The de-escalation strategy should be from the outset. And that was something the committee really actually universally agreed on. David Einstein: And that de-escalation can really take multiple forms. That could be different strategies for intermittent therapy, different start-stop strategies. It could also mean actually intensifying in the short-term with the goal long-term de-intensification, kind of analogous to kidney cancer where we might use dual checkpoint inhibitors up front with some higher upfront toxicity but with the hope of actually long-term benefit and actually being able to come off treatment and stay in remission. Those kinds of trade-offs are the types of things that are challenging to talk about. There's not a one-size-fits-all answer for every patient. And so, that's why some of these endpoints like treatment-free survival would be really helpful in actually quantifying those trade-offs and allowing each patient to make decisions that are concordant with their own wishes. Davide Soldato: Thanks so much. That was very clear, especially on the part of de-escalation, because, as you were mentioning, I think that we are globally talking about a situation, a clinical situation, where the prognosis can be very good and patients can stay off treatment for a very long period of time without compromising long-term outcomes. And I think that well-constructed de-escalation trials, as you were mentioning and as the consensus endorsed, are really needed in this space also to limit toxicity. This brings us to the end of this episode. So, I would like to thank again Dr. Einstein and Dr. Madan for joining us today. David Einstein: We really appreciate the time and the thought, and I think that even starting these types of discussions is critical. Even just recognizing that this is a unique space is the beginning of the conversation. Ravi Madan: Yeah, and I want to thank JCO for giving us this forum and the opportunity to publish these results and all the expert prostate cancer investigators who were part of this committee. We produced some good thoughts for the future. Davide Soldato: We appreciate you sharing more on your JCO article titled, "National Cancer Institute's Working Group on Biochemically Recurrent Prostate Cancer: Clinical Trial Design Considerations." If you enjoy our show, please leave us a rating and review and be sure to come back for another episode. You can find all ASCO shows at asco.org/podcasts. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinion of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.  

If you're done with being a palatable online coach and ready to GO BIGGER by leading your own movement… you're going to want to tune into this.  That's exactly what Amanda did by calibrating to the Fame Frequency and burning the Rich Rules and what we are breaking down with you today Amanda is the founder of Pinterest Board Mama and guides Badass moms to finally end the Hormonal chaos to have the energy to be with their family like they've always wanted. Tune in today to hear the internal shifts she made to go from blending in to disruptive movemnt leader and how you can too!   Get your ticket for the RICHCODED Live Event in Philadelphia here Enter into the Free Rewire Yourself Rich Lounge Apply to the RICHCODED Mastermind Enter into The Rewired Rich Room Connect on Instagram   Connect with Amanda

This conversation delves into the intricate relationship between perimenopause, insulin resistance, and the microbiome. Dr. Rebecca Sand discusses how hormonal changes during perimenopause affect insulin sensitivity, fat distribution, and overall health. The importance of dietary adjustments, particularly increasing protein intake and maintaining gut health, is emphasized as a means to manage symptoms and improve well-being during this transitional phase. The discussion also touches on the implications of aging and inflammation on mental health, highlighting the need for a holistic approach to treatment.Music provided by Blue Dot.

In this video, I share an excerpt from my book Life After Menopause, focusing on the final “E” in the EMBRACE protocol - Elimination - and why gut and microbiome health becomes so important after menopause. Your gut's role is far more than just digestion. It influences inflammation, immunity, nutrient absorption, hormone balance, weight, mood and brain health. Hormonal changes after menopause, combined with years of diet, stress and medications, can significantly affect the gut microbiome, with wide ranging effects on how we age.In this episode, you'll learn:what the gut microbiome is and why it's often called the “second brain”how menopause affects gut health, hormone metabolism and the gut–brain axissimple, practical ways to support your microbiome through diet and lifestyleI also explain when lifestyle changes aren't enough and why testing can provide clarity. Towards the end of the video, you'll learn about our new Microbiome Explorer test, an advanced gut microbiome test using metagenomic sequencing to show not just which microbes are present, but what they are doing in the gut.This episode is based on an excerpt from Life After Menopause; https://happyhormonesforlife.com/life-after-menopause.If you'd like more information about Microbiome Explorer or working with us, please get in touch - https://happyhormonesforlife.com/contact

Today, I have the privilege of connecting with Dr. Sara Gottfried! Dr. Sara is a board-certified physician who graduated from Harvard and MIT. She practices evidence-based, integrative, precision, and functional medicine. She is a Clinical Assistant Professor in the Department of Integrative Medicine and Nutritional Sciences at Thomas Jefferson University and Director of Precision Medicine at the Marcus Institute of Integrative Health. She has written four New York Times bestselling books, including her latest, Women, Food and Hormones.  Dr. Sara is one of my favorite doctors in integrative medicine and GYN! In this episode, we dive into the infodemic, how stress impacts hormones, the impact of age-related changes on hormonal regulation, alcohol, and gender differences with ketogenic lifestyles. We discuss some lesser-known hormones, including growth hormone, and how to support them properly. We touch on disordered eating, how trauma influences our relationship with food, epigenetics, and the role of a lifetime relationship with food. We also look at methylation, glutathione, detox reactions, supporting physical detoxification, and our toxic diet culture. I hope you benefit as much from this episode as I did!  IN THIS EPISODE YOU WILL LEARN: Dr. Sara explains what an infodemic is and how it has affected how she communicates with her patients.  What happens to our hormones as we age? The impact of stress on hormone regulation. Dr. Sara busts the myth that testosterone is a male hormone and discusses what testosterone means for women. How does alcohol consumption impact women's hormones? Why do men tend to have an easier time with the ketogenic diet than women? The dramatic changes that occur in women's bodies as they transition from perimenopause to menopause. Looking at the interrelationship between trauma, stress, and autoimmunity. The changes that occur with growth hormones as we age. How trauma affects the genes. How disordered eating impacts metabolism. How to support physical detoxification naturally, without going to extremes. How to address weight-loss plateaus. Connect with Cynthia Thurlow Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community (The Midlife Pause/Cynthia Thurlow)  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause supplement line Connect with Dr. Sara Gottfried On her ⁠website⁠ ⁠Facebook⁠, ⁠Instagram⁠ Dr. Sara's books are available on https://www.saragottfriedmd.com/ and ⁠Amazon.⁠

Understanding Hormonal Imbalances by Melina Roberts

Hormones influence how we move, rest, recover, and show up on the mat, yet they're rarely discussed clearly in yoga spaces. In this episode, I sit down with Dr. Manasa Rao to explore what yoga teachers need to understand about the hormonal body through both modern science and yogic wisdom. We talk about stress, rhythm, pranayama, women's hormonal cycles, and how yoga can support balance through listening and alignment without overstepping into medical advice.Episode Highlights:Are hormones a modern concept, or something yoga has always addressed through a different language?Hormones as internal messengers and their connection to yogic ideas of prana, ojas, tejas, and balance.How yoga works across the physical and subtle bodies to regulate internal harmony.The relationship between chakras, glands, and pranic flow, and where confusion often arises.Why hormonal balance is the body's natural state and how modern lifestyle disrupts rhythm.Cortisol, stress, and the importance of restoring rhythm rather than suppressing hormones.Pranayama as a key regulator of the hormonal and nervous systems.How to think about different pranayama practices, including ujjayi, with more discernment.Pratyahara as a lifestyle-based practice rooted in routine, rhythm, and sensory regulation.Understanding women's hormonal transitions, including menstruation, perimenopause, and menopause.Menopause reframed as a phase of reorganization and inward movement, not decline.How yogic practices can support different phases of the menstrual cycle.The importance of personalization and sensitivity when teaching hormonally affected students.Body-to-mind versus mind-to-body, and why dissolving that duality matters.The central takeaway: hormonal health comes from listening, alignment, and rhythm rather than fixing.Join our mailing listFind all the resources mentioned in this episodeConnect with us on InstagramSubscribe to Aham Yoga on YouTubeLet's Talk Yoga Podcast on YouTubeLeave us a review and share this podcast with your friends!

This episode is sponsored by Timeline. Support your cells and how you age with Mitopure® Gummies from Timeline. Visit https://timeline.com/FLIPPING50SHOW and save up to 39% off your Mitopure® Gummies. Other Episodes You Might Like: Previous Episode - Yoga and Bone Density: Are you just a pose away from better bones? Next Episode - What Every Woman Over 50 Needs To Know About Weight Loss and Anti Aging More Like This: Women's Health Researcher Abbie Smith-Ryan on Protein & Exercise for Longevity The Truth About Muscle and Menopause: What Every Woman Needs to Know About the Science Data Resources: Don't know where to start? Book your Discovery Call with Debra. Leave this session with insight into exactly what to do right now to make small changes, smart decisions about your exercise time and energy. Join the Flipping50 Insiders Facebook Group. Connect with other women navigating menopause fitness and get daily tips and support. Use Flipping 50 Scorecard & Guide to measure what matters with an easy at-home self-assessment test you can do in minutes. Hormonal Phase and Training Intensity has been talked about, debated, and often oversimplified—especially for women navigating midlife and menopause. Instead of opinions, myths, or influencer hot takes, this episode walks through a 2025 research that finally tested whether your cycle actually changes how hard you can train when intensity is high. If you want clarity instead of confusion about Hormonal Phase and Training Intensity, this episode is a must-listen.

Send a text for comments or topics ideas! Have you ever been told your symptoms are “just part of being a woman”?Headaches that never fully go away.Leaky bladder after childbirth.Constant fatigue.Hormonal shifts that feel overwhelming.So often, women are told these things are normal. But normal does not mean optimal.In today's episode, we're joined by a powerful voice in women's health who is redefining what resilience truly looks like. We dive into whole-body healing, nervous system regulation, and why addressing stress physiology is often the missing piece in chronic symptoms, pain, and fatigue.If you've been pushing through discomfort or quietly managing symptoms for years, this conversation will challenge you to rethink what's possible.You don't have to accept survival mode. You can build resilience. You can heal. You can thrive.What We Cover in This Episode:Why “normal” symptoms aren't always healthyThe connection between the nervous system and chronic painHow stress impacts women's hormones, fatigue, and recoveryWhat heart rate variability (HRV) tells us about resilienceWhy postpartum symptoms like bladder leaks shouldn't be ignoredThe difference between managing symptoms and true healingWhat it means to live a resilient lifestyle in every season of lifeKey Takeaways:Chronic headaches, fatigue, and pelvic floor symptoms may be common — but they are not something you simply have to live with.Nervous system regulation is foundational for long-term healing.Stress resilience impacts hormones, energy levels, inflammation, and recovery.Heart rate variability can offer insight into how well your body adapts to stress.True health care for women must look beyond surface-level symptom management.Questions to Reflect On:What symptoms have I accepted as “normal”?Where might stress be impacting my body more than I realize?Am I managing symptoms — or working toward deeper healing?What would thriving actually look like in this season of my life?----------------------------------------------------------------------------------------------------Connect with Dr. Cassie Parker: • Website: https://resilientwellnesspt.com/• Facebook: https://www.facebook.com/profile.php?id=61561663004907Instagram: https://www.instagram.com/resilient.wellness.pt/Connect with Lindsey House:   • Website: https://www.healthaccountabilitycoach.com   • Podcast: https://www.healthaccountabilitycoach.com/podcast-1   • Facebook: https://www.facebook.com/houselifestyles

Are Gen Z women ditching the Pill? Hormonal birth control was sold as liberation, but girls today are questioning everything. From brain changes and mental health risks to cancer links and fertility disruption, new studies are raising serious red flags. In this episode of The Deep, Erika breaks down the real, documented harms of hormonal contraception – and why women are starting to reject it for themselves.Timestamps:0:00 - Intro: Is Gen Z rethinking the pill?2:23 - How hormonal birth control affects your brain5:48 - What studies actually show8:10 - How the pill impacts society 10:43 - Is the tide is turning?14:25 - Conclusion: A generational rebellionWatch The Deep on Zeale: https://zeale.co/podcasts/the-deep

Procuraduría Agraria publica domicilios oficiales en el DOF Pedro Sánchez insiste en regular redes sociales para proteger a jóvenesConstitución de 1917: un pilar histórico de los derechos socialesMás información en nuestro podcast

In this informative episode of The CIRS Group podcast, hosts Jacie and Barbara welcome Dr. Anjali Noble to discuss the complexities of perimenopause, menopause, and Chronic Inflammatory Response Syndrome (CIRS). Dr. Noble, founder of the Noble Center for Health and Healing, shares insights on perimenopause and menopause, potential treatments and ways to support the transition, and how CIRS may complicate this natural process. Viewers are advised to consult their own healthcare providers for personalized medical advice.  Dr. Noble emphasizes the importance of addressing stress, improving gut health, and testing/tracking before employing hormone replacement strategies. Tune in for a deep dive into menopause, its symptoms, and what to look for in a doctor and treatment in order to manage it effectively and safely. To work with Dr. Noble, visit her website at https://drnoble.com For more CIRS information and support, visit us at https://thecirsgroup.com TIMESTAMPS 00:00 Intro and disclaimer 01:56 What is menopause? 04:32 Hormonal changes and symptoms of perimenopause 07:00 What happens with menopause, or when you hit estrogen depletion? 07:50 What are menopause symptoms and how long do they last?  10:50 Definition of perimenopause 11:55  CIRS vs menopause 17:02 Treatment recommendations for dealing with menopause 18:40 Dangers of pellets as a menopause treatment 21:45 Deal with stress first, adrenal support, then look at hormones 25:30 Lifestyle changes: gut health, methylation, detox 30:00 GLP-1s 31:29 How to work with Dr. Noble 34:30 Outro For more information and support, join us at https://thecirsgroup.com HELPFUL LINKS: Dr. Anjali Noble's informational website: https://dranjalinoble.com/ Work with Dr. Anjali Noble: https://drnoble.com Order Jacie's book! The 30 Day Carnivore Bootcamp: https://a.co/d/7MgHrRs The CIRS Group: Support Community: https://thecirsgroup.com Instagram: https://www.instagram.com/thecirsgroup/ Find Jacie for carnivore, lifestyle and limbic resources: Jacie's book on the Carnivore diet!  https://a.co/d/8ZKCqz0 Instagram: https://www.instagram.com/ladycarnivory YouTube: https://www.youtube.com/@LadyCarnivory Blog: https://www.ladycarnivory.com/ Find Barbara for business/finance tips and coaching: Website: https://www.actlikebarbara.com/ Instagram: https://www.instagram.com/actlikebarbara/ YouTube: https://www.youtube.com/@actlikebarbara Jacie is a Shoemaker certified Proficiency Partner, NASM certified nutrition coach, author, and carnivore recipe developer determined to share the life changing information of carnivore and CIRS to anyone who will listen. Barbara is a business and fitness coach, CIRS and ADHD advocate, writer, speaker, and a big fan of health and freedom. Together, they co-founded The CIRS Group, an online support community to help people that are struggling with their CIRS diagnosis and treatment.

As awareness of perimenopause- and menopause-related health concerns grows, Neda Gioia, OD, CNS, IFMCP, FOWNS says it is time for the eye care industry to recognize how profoundly hormonal shifts can affect vision and ocular comfort.Dr. Gioia said women experience hormonal transitions that differ significantly from men, yet health care systems do not consistently account for those biological differences. “Men and women are biologically different. We know this,” she says. “The discussion is why are we not actually navigating this difference with our health care system?”

This week I sit down with Autumn Calabrese to talk about fitness, mindset, and stress management—especially as they relate to women in midlife. We explore how hormonal changes can affect energy, recovery, motivation, and overall health, and why many women find that the fitness strategies that once worked no longer feel effective or sustainable. We also discuss how women's fitness culture has evolved over time, shifting away from extremes and toward a more balanced, realistic approach that prioritizes consistency over perfection. This episode highlights why managing stress is just as important as working out, and how nutrition, quality sleep, and community support play foundational roles in long-term wellness. At its core, this conversation is an invitation to reframe fitness as a tool for resilience, strength, and vitality—not punishment—and to encourage women to embrace change, stay consistent, and prioritize their health through every season of midlife. Fitness helps support warmth, energy, and resilience, especially during winter Mindset is a major driver of sustainable fitness and health habits Stress management is essential for overall health in midlife Hormonal changes can significantly impact women's physical and mental well-being Fitness culture is evolving toward balance rather than extremes Consistency in workouts leads to better long-term health outcomes Nutrition is a cornerstone of a healthy lifestyle Quality sleep is critical for recovery and overall well-being Embracing change can transform the midlife experience Community and accountability enhance motivation and long-term commitment Autumn's IG BODI platform To my fellow clinicians: listen to the You Are Not Broken podcast on ⁠⁠⁠Pinnacle's network to earn FREE CME credit⁠⁠⁠ Listen to my Tedx Talk: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Why we need adult sex ed⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Take my Adult Sex Ed Master Class:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠My Website⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Interested in my sexual health and hormone clinic? ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Waitlist is open⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Thanks to our sponsor ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Midi Women's Health⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Designed by midlife experts, delivered by experienced clinicians, covered by insurance.Midi is the first virtual care clinic made exclusively for women 40+. Evidence-based treatments. Personalized midlife care.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.joinmidi.com⁠ Learn more about your ad choices. Visit podcastchoices.com/adchoices

Most productivity advice assumes consistency is key—but what if your body tells a different story? In this enlightening episode of Healthy Mind, Healthy Life, host Sayan sits down with Renae Fieck, a feminine leadership coach, mom of three, and author of Cycle Sync Your Business. Renae shares her transformational journey from burnout to balance, revealing how syncing work, creativity, and energy with the menstrual cycle can revolutionize the way women approach time management. Together, they unpack the misconceptions around “consistency,” explore the hormonal rhythms that shape women's productivity, and highlight how working with your body instead of against it creates flow, clarity, and sustainable success. About the Guest: Renae Fieck is a speaker, coach, and author specializing in helping women align their lives and businesses with their body's natural rhythms. Through her book Cycle Sync Your Business and coaching programs, she empowers women to ditch burnout, rediscover ease, and embrace feminine flow in leadership and life. Key Takeaways: True productivity comes from honoring your body's hormonal rhythm. Consistency looks different for women—it's cyclical, not linear. Stress and overexertion disrupt hormonal balance, leading to burnout. Asking “What does my body need today?” fosters mindfulness and balance. Connect with Renae Fieck: https://renaefieck.com/  Instagram: @renaefieck Want to be a guest on Healthy Mind, Healthy Life? DM on PM - Send me a message on PodMatch

Send us a textIn this episode, I'm joined by Holly Bertone — a former FBI Chief of Staff turned Emotional Eating Profiler and coach — whose own journey through breast cancer, autoimmune disease, and high-pressure corporate life led her to completely rethink what health and success truly mean.Together, we explore why midlife can feel like a turning point for so many women, particularly when it comes to food, weight, and energy. Hormonal shifts, stress physiology, and years of pushing through fatigue often converge at this stage of life, leaving women feeling disconnected from their bodies and frustrated by habits that no longer make sense — especially emotional eating.Rather than framing this as a willpower issue, Holly offers a far more compassionate and scientific lens. We talk about the behavioural and biological drivers behind emotional eating, how chronic stress and immune dysregulation can influence cravings, and why learning to listen to your body's signals is often the most powerful place to start.This conversation is ultimately about trust — rebuilding trust with your body, moving away from rigid food rules, and developing the discernment to understand what genuinely nourishes you versus what depletes you. Because real, lasting change rarely comes from another plan; it comes from personalisation and paying attention.If you're navigating midlife changes, autoimmune symptoms, or simply feel like your relationship with food has become more complicated than it used to be, this episode will offer both clarity and reassurance.

 How to Naturally Boost Testosterone Data-backed ways to boost testosterone. (2:01) 1. Exercise. (3:18) 2. Sleep. (11:56) 3. Vitamin D. (16:51) 4. Zinc. (20:57) 5. Magnesium. (21:55) 6. Other supps/recommendations: (Fenugreek, Ashwagandha, Shilajit, Tonkat Ali, and red-light therapy.) (23:03) Related Links/Products Mentioned Boost Testosterone Guide: http://mindpumpmedia.com/testosterone-guide  Visit Crisp Power for an exclusive offer for Mind Pump listeners! ** Code MINDPUMP10 for 10% OFF. Give your snack game a serious upgrade. Crisp Power Protein Pretzels deliver super crunchy and delicious snacks that are up to 28g of protein, low carb, zero sugar, and high in fiber! ** January Promotion: Code NEWYEAR50 at checkout for 50% off the following programs: MAPS Starter, Transform, Anabolic, and Performance! Visit: http://mapsjanuary.com/  Mind Pump Store Various Factors May Modulate the Effect of Exercise on Testosterone Levels in Men Endogenous transient doping: physical exercise acutely increases testosterone levels-results from a meta-analysis Sleep and Testosterone: The Essential Connection for Optimal Health Association Between Vitamin D Deficiency and Testosterone Levels in Adult Males: A Systematic Review Effect of Zinc on Testosterone Levels and Sexual Function of Postmenopausal Women: A Randomized Controlled Trial Zinc status and serum testosterone levels of healthy adults Effect of fenugreek extract supplement on testosterone levels in male: A meta‐analysis of clinical trials A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha (Withania somnifera) in Aging, Overweight Males Tongkat Ali benefits, dosage, and side effects - Examine Mind Pump Podcast – YouTube Mind Pump Free Resources  

Helen Bennett, counsellor and psychotherapist, explores hormone-aware therapy practices and how hormonal shifts can influence neurodivergent presentations in clients assigned female at birth, with a focus on reducing distress, improving clinical understanding, and avoiding misdiagnosis. Interview with Elizabeth Irias, LMFT. Earn CE credit for listening to this episode by joining our low-cost membership for unlimited podcast CE credits for an entire year, with some of the strongest CE approvals in the country (APA, NBCC, ASWB, and more). Learn, grow, and shine with Clearly Clinical Continuing Ed by visiting https://ClearlyClinical.com.

Dr. Elizabeth Poynor is a gynecologic oncologist, Chair of Women's Health at Atria Health Institute, and host of the podcast “Decoding Women's Health.” This conversation explores why women's health has been siloed for centuries, modern hormone therapy, the estrogen-brain connection, metabolic shifts, GLP-1s, and what partners need to understand about this transition. Underneath it all: generations of women have known what the medical literature is only now catching up to. Elizabeth is a vital voice. I hope this discussion reaches those who need it. Enjoy! Show notes + MORE Watch on YouTube Newsletter Sign-Up Today's Sponsors: Go Brewing: Use the code Rich Roll for 15% OFF

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Lisa Mosconi is a world-renowned neuroscientist and the director of the Women's Brain Initiative at Weill Cornell Medicine, where she studies how sex differences and hormonal transitions influence brain aging and Alzheimer's disease risk. In this episode, Lisa explores why Alzheimer's disease disproportionately affects women and why longer lifespan alone does not explain their nearly twofold risk compared to men. She explains why Alzheimer's disease may be best understood as a midlife disease for women, beginning decades before symptoms appear, and how menopause represents a fundamental brain event that reshapes brain energy use, structure, and immune signaling. The conversation also examines what advanced brain imaging reveals about preclinical Alzheimer's disease, estrogen receptors in the brain, and why genetic risks such as APOE4 appear to affect women differently from men. Finally, Lisa discusses the nuanced evidence around menopause hormone therapy, the legacy of the WHI, her new CARE Initiative to cut women's Alzheimer's risk in half by 2050, and practical, evidence-based strategies to support brain health through midlife—including lifestyle, sleep, metabolism, mood, and emerging therapies such as GLP-1 agonists and SERMs (selective estrogen receptor modulators). We discuss: How Lisa's personal family history and scientific background led her to focus on the intersection of women's health, brain aging, and Alzheimer's disease (AD) [2:45]; The long preclinical phase of AD and the emotional burden carried by patients before dementia becomes severe [7:15]; How AD compares to other common forms of dementia: prevalence, pathology, symptoms, diagnostic challenges, and more [10:45]; Why AD disproportionately affects women: how AD is not simply a disease of old age or longevity but a midlife disease in which women develop pathology earlier [16:15]; Menopause as a leading explanation for women's increased Alzheimer's risk, and how advanced braining imaging can detect early changes in the brain [26:15]; How a new method for imaging estrogen receptors in the brain is changing how we think about the menopause transition [35:45]; What estrogen receptor imaging can and cannot tell us about hormone therapy's potential impact on brain health [48:45]; Lisa's studies on the relationship between levels of systemic estrogen and density of estrogen receptors in the brain [58:00]; Why blood estrogen levels poorly reflect brain estrogen signaling, and how tightly regulated brain hormone dynamics complicate our understanding of menstrual-cycle and lifestyle effects [1:02:15]; The CARE Initiative: Lisa's research program looking to slash AD rates in women [1:07:45]; The dramatic difference in AD risk between men and women associated with APOE4 [1:10:45]; What the evidence suggests about menopausal hormone therapy (MHT) and AD risk, and why timing, formulation, and uterine status appear to matter [1:12:00]; How the CARE initiative plans to study MHT and AD risk, within the practical constraints of a three-year research window [1:17:30]; How to think about starting hormone therapy during perimenopause: balancing symptom relief, hormonal variability, and individualized care [1:21:00]; Investigating selective estrogen receptor modulators (SERMs) as a targeted approach to brain health during and after menopause [1:25:00]; Why estrogen became wrongly associated with cancer risk and what the evidence actually shows [1:29:30]; Why better biomarkers are central to advancing women's Alzheimer's research [1:38:30]; Modifiable risk factors for dementia, the limitations of risk models, and questionable conclusions drawn from observational data [1:44:15]; GLP-1 agonists and brain health: exploring potential neuroprotective effects of GLP-1 agonists beyond metabolic benefits [1:49:00]; The importance of lifestyle factors in reducing risk of dementia: practical strategies for women to support brain health [1:53:45]; Why long-term, consistent lifestyle habits are essential for building cognitive resilience and protecting brain health over decades [2:01:15]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube