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Mickael Dang is co-founder of Synakis, a biotech startup developing groundbreaking technology for the treatment of retinal detachment. Still in startup mode, the company is part of UTEST, the University of Toronto's Early Stage Technology Program, which helps deep tech entrepreneurs go from lab to market. Mickael and Wendy connected at the Redefining Early Stage of Investment (RESI) Conference in Boston, where Synakis was among the highest-scoring companies in the Innovator's Pitch Challenge. (The RESI conference is hosted by Life Science Nation and Wendy recently interviewed Dennis Ford, founder and CEO of Life Sciences Nation, which specializes in fundraising for life sciences companies.) Mickael's journey is fascinating. When he arrived in Canada from France six years ago, he could barely string together an English sentence. Today, we find him at the intersection of scientific innovation, entrepreneurship, and global market expansion, having started Synakis while earning a PhD and serving as President of the Student and Young Investigator Section (SYIS) of TERMIS (Tissue Engineering and Regenerative Medicine Society). He is also multilingual; he speaks French, English, and some Mandarin. “The PhD is the same concept as being an entrepreneur,” he says. “You need to be very self-driven, very independent as well. You have to come up with your own experiment and come up with the next predicted results. I had this entrepreneurial mindset from the get-go and wanted to do a PhD for purpose, to really get the company out there." Incubated in the laboratory of renowned biomedical engineering professor Dr. Molly Shoichet, Synakis is developing a revolutionary hydrogel-based technology called SNK125. This innovation promises to transform the recovery process for patients suffering from retinal detachment, a serious condition that requires immediate surgical intervention to prevent permanent vision loss. Current treatments for retinal detachment involve using silicon oil or heavy gases to push the detached retina back into place. While these methods work, they come with significant drawbacks. Patients experience blurry vision during recovery and must maintain exhausting, face-down posturing for hours, sometimes for months. In addition, the materials used aren't biodegradable, requiring a second surgery for removal. Synakis's hydrogel technology eliminates all of these challenges, while reducing recovery time from months to just days. The Global Path to Market Equally interesting is the company's approach to global market entry. Based in Canada, the company has already laid the groundwork for international expansion; in 2019, Mickael proactively filed patents across multiple territories, including Europe, Australia, Canada, and China, to ensure protection of its intellectual property globally. And rather than attempting to tackle multiple markets simultaneously, Synakis will initially focus on North America before expanding to Europe and China. This staged approach allows them to establish a strong foundation in their home market while building the partnerships and relationships required for international expansion. Throughout, Mickael and his team have been actively seeking partnerships with established industry giants like Alcon or Bausch & Lomb. There are high costs associated with clinical trials these companies – companies that "own the entire market," according to Mickael – have the expertise and distribution networks necessary for successful commercialization. Funding the Future Synakis is concurrently seeking seed investment and focusing on several critical milestones: Good Manufacturing Practices (GMP) setup, FDA regulatory filing, and preparation for clinical trials. While its primary focus is on North American investors for practical reasons like time zone alignment and ease of communication, they're keeping their options open for international investment, particularly in regions like China, which possess significant market opportunity. Mickael has constructed a targeted and strategic approach to investor outreach. At the RESI conference, for example, he prioritized meetings with specialized investors like ExSight Ventures, who focus specifically on ophthalmology. These are the meaningful conversations with investors that will ask the hard questions and offer solutions. Looking Ahead Synakis is currently preparing for its next phase of growth. Plans include moving out of the university incubator, creating new jobs in Toronto, and expanding their product pipeline beyond retinal detachment treatments to include drug delivery solutions for other eye conditions. Mickael's key takeaways from his Synakis journey are relevant for any company planning international expansion: Strategic IP Protection: Early patent filing in target markets will protect future opportunities. Staged Market Entry: Starting with familiar markets before expanding globally can help manage resources and risk effectively. Strategic Partnerships: Recognizing when to partner with established players can accelerate market entry and provide access to crucial resources. Targeted Investor Outreach: Focusing on investors who understand your industry can lead to more productive relationships. Cultural Adaptability: Language skills and cultural understanding are invaluable assets in building a global business. Going from lab to market can be, as Mickael says it in French, a "casse-tête" (a “head-breaker”), but the right approach, persistence, and strategic thinking can ultimately turn scientific innovation into global market success. Listen to the full episode to hear more about Synakis's journey from university lab to potential global market player, plus more real-world advice for expanding internationally. Links: LinkedIn: https://www.linkedin.com/in/mickael-dang/ Website: https://www.linkedin.com/company/synakis/ https://utest.to/ https://termis.org/index.php?q=termis-syis-am
Klick hier, um deine mentale Stärke entschlossen zu revolutionieren In dieser Episode spreche ich darüber, was es für eine "große" Hürde gibt, wenn du beginnst, einen neuen Weg einzuschlagen und erkläre leicht verständlich, was du beachten musst, um deine Ziele zu erreichen. Was dein Selbstbild und deine Identität damit zu tun haben und wie du eine neue Ära für dich einläutest!
If you're a real estate agent, there's a good chance you're entrepreneurial, driven, and know how to wear many hats in business. As such, you may at some point want to explore a side hustle (that isn't driving an Uber). Not that there is anything wrong with driving an Uber, but it tends to be very time-consuming. In this episode, we look at 10 side hustles for real estate agents. Some of these will be real estate-related like property management and short-term rental management, but you'll also see a few out-of-the-box side hustles! And note that side hustles can be for additional income or just pure interest! Both are perfectly acceptable! 0:00 Intro 1:54 Short-term rental management 3:29 Selling digital products on Etsy (or a similar platform) 4:49 Tutor future agents who are going through the course 5:55 Real estate mentor 7:32 Pet sitting 8:52 Neighbourhood tours (for example on Airbnb experiences or Showaround) 10:27 Property management 11:32 Investment properties 13:12 Learning how to invest 14:51 User testing (UserTesting, UTest, Userlytics, UserCrowd, and Enroll) Sign up for the weekly Rev Real Estate School Newsletter: https://rev-real-estate-school.ck.page/5b0889360c Social Media: TikTok: https://www.tiktok.com/@revrealestateschool Instagram: https://www.instagram.com/revrealestateschool/ Facebook: https://www.facebook.com/revrealestateschool Rev Real Estate School is here to teach real estate agents how to become successful in their careers and scale anywhere from 0-100 transactions while working 5 days per week by working your SOI. The real estate agent tips and tricks will benefit beginner agents and growing REALTORs® with marketing ideas, database marketing, social media, scripts, dialogues, habits, mindset, networking, skills, and negotiation.
Hallandsposten har granskat förekomsten av kokain och droger i Halmstads uteliv. I detta avsnitt får vi göra reportrarna Amanda Pettersson och Michael Larsson berätta om hur det var bakom kulisserna under den här granskningen. Utrustade med speciella servetter undersökte de toaletterna på krogar, nattklubbar och restauranger för att se om man kunde se spår av kokain – och det kunde man. Programledare är Johan Hammerby.
Redaktionen sparkar igång säsongen med de plattaste efter semester-sägningarna, Stockholms skitnödigaste uteställen avslöjas, och en frånvarande Mikke Ljunggren lackar per länk.I måndagens program listar Fredrik sina topp Gushådsmoments och August testar nytt segment i samma stuk: Blir det gås?I eftersnacket: smygfilmning av Ola Rapace har läckt till Gott Snack från Nemo Hedéns livepod, detta ska såklart avhandlas.Support this show http://supporter.acast.com/gott-snack-med-fredrik-soderholm. Our GDPR privacy policy was updated on August 8, 2022. Visit acast.com/privacy for more information.
När Rasmus Paludan ville demonstrera i Borås fick han avslag. Såhär löd motiveringen: Polisen har med hänsyn till den hot och riskbedömning samt de allvarliga ordningsstörningar och våldsamma upplopp som inträffade under påskhelgen beslutat om avslag.Men det var det som sades därefter som ledde till höjda ögonbryn. Kommenderingschefen Emelie Kullmyr meddelade även att: Rasmus Paludan har en retorik som går ut på att skapa oordning och kaos. Vi behöver hjälpas åt att för att slå hål på den retoriken.Är det rimligt att vi har polischefer som fattar beslut baserat på personliga åsikter? Ska polisen verkligen recensera dem som vill nyttja sina fri- och rättigheter? Och är detta en del av en bredare trend?I dagens podd pratar jag med Jakob Heidbrink, universitetslektor på juridiska institutionen vid Göteborgs universitet, om detta och om olika tjänstemannaideal som står mot varandra, riskerna med att staten blir mer tillrättavisande mot medborgarna, olika definitioner av demokrati som är svåra att förena, hur tjänstemannaaktivismen motiveras med hänvisning till nazismen, och mycket annat. Dessutom pratar vi om traditionella europeiska kampsporter (HEMA), som Jakob tränar. Själv är han främst inriktad på långsvärd och sabel, men det finns ett antal andra stilar och vapen. Vi pratar om hur realistiska striderna i Game of thrones och The Witcher verkligen är, med mera. Bonusfråga: Vilket svärd är bäst ur självförsvarssynpunkt? (Se bild längst ned.)Länkar till dagens avsnittJakob Heidbrink – “Inte bara Transportstyrelse har problem”De många skandalerna inom myndigheter och verk som mött oss är inte enskilda händelser. De är delar av en allmän förvaltningskris, varnar Jakob Heidbrink. Han spårar krisens rötter till alltför ytliga normer för myndighetsutövning, normer komna ur förenklade ekonomiska och statsvetenskapliga resonemang. (Kvartal 12/12 -17)Jakob Heidbrink – “Nürnberg står inte för dörren”Att Migrationsverket agerar för en mer liberal migration än vad lagen ger stöd för, är ett utslag av antidemokratisk aktivism från enskilda tjänstemän. Därmed reses samma frågor i Sverige som i USA, där tjänstemän inom Trumps egen förvaltning i skydd av anonymitet medgett att de obstruerar presidentens politik – för att de inte håller med honom: Det skriver Jakob Heidbrink, docent i juridik. (Kvartal 17/9 -18)Jakob Heidbrink – “Politiskt upprop från 261 opolitiska tjänstemän” 261 opolitiska tjänstemän i UD skriver i ett upprop, ställt till Regeringskansliets förvaltningschef, att man oroas över huruvida nästa regering kan komma att urholka ”värdegrunden” i Regeringskansliets arbete. Det avslöjade Ledarsidorna.se i går. I brevet ställer man tjänstemäns ”lojalitetsplikt” mot ”grundlagens bestämmelser om människors lika värde.” Därmed aktualiseras nu frågan om tjänstemannaobstruktion, som Kvartal tidigare behandlat i två artiklar. (Kvartal 27/9 -18)Följ Jakob Heidbrink på hans facebooksida. Och för den som är intresserad historical european martial arts (HEMA) kan man läsa mer här till exempel. Exakt såhär ser det ut när man tränar som nybörjare (inte riktigt: Och duellen som Jakob nämner är alltså den här, från filmen “Deluge” (Potop på polska):Visst blir man lite intresserad av att pröva? Med aningen mer skydd än i dessa två videos. Numera verkar det finnas HEMA-klubbar lite varstans i Sverige.Svärdet Jakob rekommenderar i slutet av podden (ser lite ut som en machete, va?):Jag mottar inga statliga bidrag eller annan finansiering, utan förlitar mig helt på er läsare och lyssnare. Genom att bli betalande prenumerant gör man det möjligt för mig att fortsätta vara en självständig röst.Utgivaren ansvarar inte för kommentarsfältet. (Myndigheten för press, radio och tv (MPRT) vill att jag skriver ovanstående för att visa att det inte är jag, utan den som kommenterar, som ansvarar för innehållet i det som skrivs i kommentarsfältet.) This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit ivararpi.substack.com/subscribe
As with most entrepreneurs, you never forget the people who supported you from the early days of the company. I first met Matt towards the end of 2009. VentureFizz had recently launched and I was looking for advertising sponsors to help fund future development of the site. At that point in time, Matt was heading up marketing for a company called uTest (now called Applause) and they were looking to increase exposure for the company. It ended up being a great match and they were the first company to sponsor VentureFizz. Without that check… who knows what would have happened. So grateful. Matt has been involved in lots of venture backed tech companies that have scaled. His career progressed through the marketing ranks into leadership positions to the point of becoming a CEO for startups. Thus, I was excited to hear about his professional journey and all the stories of scaling companies, plus the lessons learned along the way. Matt recently joined GitKraken, the maker of some of the most popular developer tools in the entire Git ecosystem, as their CEO. In this episode of our podcast, we cover: * Advice on transitioning through the leadership ranks to a CEO position. * Matt's backgroundl in terms of growing up in Michigan and what he learned from his early experience at Herman Miller. * The story behind the fast track of his career to the point of leading marketing at startups and the details on scaling Applause. * How he transitioned into a CEO position at Mautic and their acquisition by Acquia. * All the details on GitKraken and their growth plans ahead. * And so much more. If you like the show, please remember to subscribe and review us on iTunes, Soundcloud, Spotify, Stitcher, or Google Play.
Är du en pappa som har svårt eller får träffa dina barn? Denna video är till dig broder. Det ordnar sig om du håller linan sträckt ♥️♥️♥️ I denna video delar jag med av hur jag gjorde ♥️
Flera europeiska länder, däribland Finland har under veckoslutet helt ställt in passagerartrafiken från Storbritannien i väntan på att vi ska få veta mer om den nya coronavirusvarianten som är mer smittsam än den tidigare. I Storbritannien uppmanar myndigheterna människor att behandla alla som om de vore smittade. Redan nu har också den viktiga godstrafiken mellan Frankrike och Storbritannien i princip stannat upp. En försmak på vad som kan komma om andet i slutet av året träder ut ur EU:s inre marknad utan handelsavtal, den så kallade hårda Brexit. Hur ska britterna klara det här? I Slaget efter tolv diskuterar Charlotta Buxton, Svenska Dagbladets korrespondent i London, Rasmus Almqvist, finlandssvensk affärsman som efter flera år i Storbritannien på grund av Brexit valde att flytta hem, samt handelsexperten Julia Mäklin. Programledare: Stefan Winiger E-post: slaget@yle.fi
Doron is the Co-Founder and CEO of Applause (formerly uTest), a crowdtesting market and a market leader. His leadership made him an internationally-recognized expert in software development, testing and entrepreneurship. Additionally to running Applause, Doron is an avid runner and cyclist, competing in the Boston Marathon more than 10 times and triathlons regularly (Board Member of RunKeeper).
Гости: Катерина Кравченко - живет в центре всего IT мира Темы: - 00:01:09 - Начало - 00:01:12 - Гость - 00:04:00 - Про опыт до переезда - 00:09:12 - Как проходят собеседования? - 00:20:22 - Как искать жилье? - 00:24:25 - Какой бюджет? - 00:29:30 - В каком штате ты и почему именно туда? - 00:31:01 - UTest стоит ли пробовать для прокачки опыта? - 00:33:37 - Что изменилось после переезда и не тянет ли назад? - 00:35:23 - Что требуют от тестировщика у них? Сертификаты, программирование, ДевОпс и т.п.? - 00:39:49 - Айтишная тусовка и конференции там и тут ? - 00:43:20 - Скок и как понять уровень зп? - 00:52:22 - Налоги страшные? - 00:56:52 - FAANG - 01:00:45 - А что если заболеешь? - 01:07:47 - Какие тренды сейчас? - 01:13:34 - Как часто происходят прибавки к ЗП? - 01:20:49 - Работа там? Какие особенности? Скрам, не скрам? - 01:27:50 - Купить или снимать? - 01:33:39 - Когда захотелось завести YouTube канал? - 01:34:35 - Про курсы вайтишников там - 01:42:56 - Советы тем кто хочет переехать - 01:52:25 - Гражданство - 01:54:56 - Патроны - 01:55:35 - Финал Канал Кати в youtube - Katya Kravchenko US Life https://www.youtube.com/channel/UCmiv7ZiPmP98mr2Lrfxg8lA Telegram: t.me/automation_remarks Стать патроном: www.patreon.com/automation_remarks Спасибо патронам: Igor Gruziev, Maryna Kolesnik, Miguel Suddya, Tetiana Hrybok, Alisa Markova, Marat Reymers, Vitaly Fedrunov, Kuptsov Ivan, Anastasiya Mazheika, Oleksii Korchkov, Mykola Podolianiuk, Nikita Verbitsky, Maxim Denisov, Перетятько Игорь, Nikolay Georgievskiy, Alex Hramovich, Vitalii
It feels like every business and brand are increasingly focussing on creating unique digital customer experiences to provide the wow factor. As the experience economy gathers place, we need to remember that we can only improve what we can measure. But is there a way to test the effects of these new experiences that we are creating? Applause, the worldwide leader in digital quality and crowdsourced testing, helps hundreds of leading brands improve the quality of their digital experiences by testing with real users, on real devices, in native languages, under real conditions. Applause recently launched Applause Labs, the industry's largest innovation team dedicated to the quality and testing of applications. Applause Labs also released the first and only enterprise-quality benchmarking tool – the Applause Quality Score (AQS). Leveraging 11+ years of data on digital quality issues, the AQS will deliver insights into clients' overall quality at the build, release, and product level, along with other benchmarking features. This is the future of digital quality and will impact most of the apps on your phone right now. I invited Doron Reuveni onto the podcast to talk about how important digital quality is to brands today, and how Applause Labs and the AQS will empower these businesses to meet their customers' high expectations for digital quality. Doron Reuveni is the Chief Executive Officer and Co-Founder of Applause. Since founding Applause (formerly uTest) in 2007, Doron has led the creation of the crowdtesting market and solidified Applause's position as the market leader. Doron's leadership has made him an internationally-recognized expert in software development, testing, and entrepreneurship. Although the idea of "in-the-wild" software testing through a crowdsourcing model was a radical notion when Applause was founded, today, it has become an integral part of the software development process for thousands of companies worldwide. Under Doron's leadership, Applause has evolved into an enterprise-grade solution, meeting the complex requirements of the world's most influential brands. Doron's vision has transformed Applause into the digital quality leader through expanded product offerings, investment in its SaaS platform, and growth in our global community of vetted digital experts.
Start your free 7-day (no-risk) trial at https://AirCall.io/hack Learn how you can save time and money with Intuit Quickbooks. Go to Intuit.me/hack Sharon Savariego is the former business development manager of uTest, community advocate, and serial social entrepreneur. Back in 2014, Sharon Savariego came up with the idea to build a platform to empower Community Managers around the world. Needing help with the tech side of things, she began the quest for a tech co-founder, which she found and they began planning, raising money, and building. Today, Mobilize serves as an online hub for over 1,000 communities and 1,000,000 members. This is a fascinating conversation where we discuss creating compelling reasons to buy, why everything has an element of community, and honing a vision. Now, let's hack! Sharon Savariego
"Jag är lite efterbliven" säger Hertha. Vi pratar om hur man ska kunna involvera äldre människor i dagens moderna teknik. Många gamla människor skulle haft stor glädje av att kunna lyssna på poddar, se filmer och upptäcka ljudböckernas värld, men de vet inte hur man gör och vågar inte testa sig fram. Hur hjälper vi våra äldre med tekniken? Hon är även frustrerad över att allting tar så lång tid. Hon upplever att allt kräver så mycket energi för en gammal människa. Det ligger en stor frustration i att inte klara av det man tidigare kunnat. Det man fortfarande kan tar så mycket krafter att man måste vila långa stunder både före och efter. Tycker du att detta är ett värdefullt sätt att bevara historien, lyfta fram en gammal människas visdom och låta en gången tids tankesätt möta dagens? Då får du innerligt gärna hjälpa oss att hålla igång den med en slant via Swish. Det går till tågbiljetter för mig, Louise, att ta mig till och från gammelmormor Hertha, månatligt podcasthotell, inspelningsinstrument och andra utgifter. Stor eller liten gåva - allt hjälper oss att fortsätta. Swisha i sådant fall till nummer: 0704204404 Stort tack.
Welcome to Episode 127 of The VentureFizz Podcast, the flagship podcast from the leading authority for jobs & careers in the tech industry. For this episode of our podcast, I interviewed Doron Reuveni, Founder and CEO of Applause. Building a successful company is incredibly difficult. It is definitely not a sprint, it's not even a marathon… it is more like an Ironman competition where you have to train for multiple events and do it at a massive scale. Well, Doron can definitely relate to this analogy, as an Ironman competitor, biker, and marathoner. He and his co-founder, Roy Solomon, disrupted the software testing industry with a new approach by leveraging a crowdsourcing model. Applause went on to raise over $115M in funding and was acquired by Vista Equity Partners in 2017. Here's a fun fact: Applause was originally known as uTest and they were one of the very first sponsors of VentureFizz. It was uTest, General Catalyst, and Akamai. Without their support in the early days of VentureFizz… we might not even exist! In this episode of our podcast, we cover lots of topics, like: -Doron's background story and professional history. -How the idea for uTest originated, how they built out the community of testers, and started to gain traction with customers. -The story behind the rebranding of the company. -The current state of their business in terms of size and scale. -Advice for founders on how to remain as CEO of your company over the long term. -The hardest part of scaling a business -How to build a management team. -And so much more. Did you know that you can get customized job alerts delivered to your inbox every day? It's a great way to keep informed of the over 4,000 jobs listed on VentureFizz and have jobs from a specific category sent directly to you. Don't let that career-defining opportunity pass you by, go to venturefizz.com/email to sign up. Lastly, if you like the show, please remember to subscribe to and review us on iTunes, or your podcast player of choice!
Anis don Demina berättar om sitt galna uteliv i Dubai!
This week on IAQradio+ will be broadcasting live from the Open House event for the HOMEChem study at the University of Texas Austin’s, J.J. Pickle Research Campus. The HOMEChem experiment (House Observations of Microbial and Environmental Chemistry) incorporates state-of-the-art measurements performed by over 20 investigators and their teams from the fields of chemistry, microbiology, and engineering. This experiment engages far more institutions and disciplines than ever applied to the study of a home. This research study is sponsored by the Alfred P. Sloan Foundation Chemistry of Indoor Environments Program and it will take place this summer at the University of Texas at Austin’s UTest House. Our guests for this special show are Marina Vance (HOMEChem Co-PIs / organizer) Delphine Farmer (HOMEChem Co-PIs / organizer) Atila Novoselac (HOMEChem host, specialist on the UTest house) Rich Corsi (HOMEChem host, indoor air specialist) Dr. Richard L. Corsi is the Joe J. King Chair in Engineering #2 in the Department of Civil, Architectural and Environmental Engineering (CAEE) at The University of Texas at Austin (UT Austin). He has served on the faculty of CAEE at UT Austin for nearly 25 years, after starting his career in the School of Engineering at the University of Guelph in Ontario, Canada. Dr. Corsi is highly regarded as an educator. He has received numerous teaching awards, and in 2015 was inducted into the Academy of Distinguished Teachers, an honor held for the top 5% of teachers across UT Austin. He also received a Regents’ Outstanding Teaching Award for the entire UT system in 2016. Dr. Corsi’s research focuses on sources, physics and chemistry of indoor air pollution, particularly as related to pollutant interactions with indoor materials and innovative strategies for using such interactions to reduce human exposure to air pollution of both outdoor and indoor origin. He has served as principal investigator on over 70 projects, as major advisor to over 50 undergraduate and 70 graduate students, and as co-author on over 300 journal/conference papers, reports, and book chapters. His work has been featured in National Geographic, The Economist, Business Week, National Wildlife, Prevention, Men’s Health, National Public Radio’s Science Friday, Science Studio, the Academic Minute, the Canadian television series The Nature of Things, and more. Delphine Farmer, PhD Dr. Delphine Farmer is an Associate Professor in the Department of Chemistry at Colorado State
This week on IAQradio+ will be broadcasting live from the Open House event for the HOMEChem study at the University of Texas Austin’s, J.J. Pickle Research Campus. The HOMEChem experiment (House Observations of Microbial and Environmental Chemistry) incorporates state-of-the-art measurements performed by over 20 investigators and their teams from the fields of chemistry, microbiology, and engineering. This experiment engages far more institutions and disciplines than ever applied to the study of a home. This research study is sponsored by the Alfred P. Sloan Foundation Chemistry of Indoor Environments Program and it will take place this summer at the University of Texas at Austin’s UTest House. Our guests for this special show are Marina Vance (HOMEChem Co-PIs / organizer) Delphine Farmer (HOMEChem Co-PIs / organizer) Atila Novoselac (HOMEChem host, specialist on the UTest house) Rich Corsi (HOMEChem host, indoor air specialist) Dr. Richard L. Corsi is the Joe J. King Chair in Engineering #2 in the Department of Civil, Architectural and Environmental Engineering (CAEE) at The University of Texas at Austin (UT Austin). He has served on the faculty of CAEE at UT Austin for nearly 25 years, after starting his career in the School of Engineering at the University of Guelph in Ontario, Canada. Dr. Corsi is highly regarded as an educator. He has received numerous teaching awards, and in 2015 was inducted into the Academy of Distinguished Teachers, an honor held for the top 5% of teachers across UT Austin. He also received a Regents’ Outstanding Teaching Award for the entire UT system in 2016. Dr. Corsi’s research focuses on sources, physics and chemistry of indoor air pollution, particularly as related to pollutant interactions with indoor materials and innovative strategies for using such interactions to reduce human exposure to air pollution of both outdoor and indoor origin. He has served as principal investigator on over 70 projects, as major advisor to over 50 undergraduate and 70 graduate students, and as co-author on over 300 journal/conference papers, reports, and book chapters. His work has been featured in National Geographic, The Economist, Business Week, National Wildlife, Prevention, Men’s Health, National Public Radio’s Science Friday, Science Studio, the Academic Minute, the Canadian television series The Nature of Things, and more. Delphine Farmer, PhD Dr. Delphine Farmer is an Associate Professor in the Department of Chemistry at Colorado State
This week on IAQradio+ will be broadcasting live from the Open House event for the HOMEChem study at the University of Texas Austin’s, J.J. Pickle Research Campus. The HOMEChem experiment (House Observations of Microbial and Environmental Chemistry) incorporates state-of-the-art measurements performed by over 20 investigators and their teams from the fields of chemistry, microbiology, and engineering. This experiment engages far more institutions and disciplines than ever applied to the study of a home. This research study is sponsored by the Alfred P. Sloan Foundation Chemistry of Indoor Environments Program and it will take place this summer at the University of Texas at Austin’s UTest House. Our guests for this special show are Marina Vance (HOMEChem Co-PIs / organizer) Delphine Farmer (HOMEChem Co-PIs / organizer) Atila Novoselac (HOMEChem host, specialist on the UTest house) Rich Corsi (HOMEChem host, indoor air specialist) Dr. Richard L. Corsi is the Joe J. King Chair in Engineering #2 in the Department of Civil, Architectural and Environmental Engineering (CAEE) at The University of Texas at Austin (UT Austin). He has served on the faculty of CAEE at UT Austin for nearly 25 years, after starting his career in the School of Engineering at the University of Guelph in Ontario, Canada. Dr. Corsi is highly regarded as an educator. He has received numerous teaching awards, and in 2015 was inducted into the Academy of Distinguished Teachers, an honor held for the top 5% of teachers across UT Austin. He also received a Regents’ Outstanding Teaching Award for the entire UT system in 2016. Dr. Corsi’s research focuses on sources, physics and chemistry of indoor air pollution, particularly as related to pollutant interactions with indoor materials and innovative strategies for using such interactions to reduce human exposure to air pollution of both outdoor and indoor origin. He has served as principal investigator on over 70 projects, as major advisor to over 50 undergraduate and 70 graduate students, and as co-author on over 300 journal/conference papers, reports, and book chapters. His work has been featured in National Geographic, The Economist, Business Week, National Wildlife, Prevention, Men’s Health, National Public Radio’s Science Friday, Science Studio, the Academic Minute, the Canadian television series The Nature of Things, and more. Delphine Farmer, PhD Dr. Delphine Farmer is an Associate Professor in the Department of Chemistry at Colorado State
This week on IAQradio+ will be broadcasting live from the Open House event for the HOMEChem study at the University of Texas Austin's, J.J. Pickle Research Campus. The HOMEChem experiment (House Observations of Microbial and Environmental Chemistry) incorporates state-of-the-art measurements performed by over 20 investigators and their teams from the fields of chemistry, microbiology, and engineering. This experiment engages far more institutions and disciplines than ever applied to the study of a home. This research study is sponsored by the Alfred P. Sloan Foundation Chemistry of Indoor Environments Program and it will take place this summer at the University of Texas at Austin's UTest House. Our guests for this special show are Marina Vance (HOMEChem Co-PIs / organizer) Delphine Farmer (HOMEChem Co-PIs / organizer) Atila Novoselac (HOMEChem host, specialist on the UTest house) Rich Corsi (HOMEChem host, indoor air specialist) Richard L. Corsi, PhD Dr. Richard L. Corsi is the Joe J. King Chair in Engineering #2 in the Department of Civil, Architectural and Environmental Engineering (CAEE) at The University of Texas at Austin (UT Austin). He has served on the faculty of CAEE at UT Austin for nearly 25 years, after starting his career in the School of Engineering at the University of Guelph in Ontario, Canada. Dr. Corsi is highly regarded as an educator. He has received numerous teaching awards, and in 2015 was inducted into the Academy of Distinguished Teachers, an honor held for the top 5% of teachers across UT Austin. He also received a Regents' Outstanding Teaching Award for the entire UT system in 2016. Dr. Corsi's research focuses on sources, physics and chemistry of indoor air pollution, particularly as related to pollutant interactions with indoor materials and innovative strategies for using such interactions to reduce human exposure to air pollution of both outdoor and indoor origin. He has served as principal investigator on over 70 projects, as major advisor to over 50 undergraduate and 70 graduate students, and as co-author on over 300 journal/conference papers, reports, and book chapters. His work has been featured in National Geographic, The Economist, Business Week, National Wildlife, Prevention, Men's Health, National Public Radio's Science Friday, Science Studio, the Academic Minute, the Canadian television series The Nature of Things, and more. Delphine Farmer, PhD Dr. Delphine Farmer is an Associate Professor in the Department of Chemistry at Colorado State University. Her research focuses on building new instrumentation to measure reactive trace gases and particles in the atmosphere in order to understand how humans are changing our environment. She is particularly interested in the emissions from forests, and has recently taken the dive into the complex world of indoor chemistry. Dr. Farmer grew up in Canada, and received her BSc in Chemistry from McGill University in Montreal. She moved to warmer climates to earn her Master's in Environmental Science, Policy and Management and her PhD in Chemistry, both from the University of California at Berkeley. Her research focused on using laser spectroscopy to study forest-atmosphere interactions. Delphine then held a NOAA Climate and Global Change Postdoctoral Fellowship at the University of Colorado Boulder, working with aerosol mass spectrometers in forests in the Brazilian Amazon and California's Sierra Nevada mountains. Atila Novoselac, PhD Dr. Atila Novoselac is a Professor in the Department of Civil, Architectural and Environmental Engineering at the University of Texas at Austin. He holds B.S. and M.S. degrees in Mechanical Engineering from Belgrade University and in 2005 received his PhD in Architectural Engineering from the Pennsylvania State University. The ultimate goal of his research is to improve buildings with respect to their impact on occupants' health and overall energy performance. He conducts both fundamental and applied research that leads to healthy and efficient buildings. Specifically, his work focuses on: (1) investigating transport phenomena in buildings that influence human exposure to airborne pollutants and pathogens, and (2) developing methods to improve the thermal characteristics and energy performance of building systems. His research is merging the energy, indoor environment, and human exposure aspects of buildings for developing integrated design/operation solutions. He teaches courses on the subjects of building mechanical systems, building physics, and advanced measuring and modeling techniques for performance analysis of building environmental control systems. He is an active member of the American Society of Heating, Refrigerating and Air-Conditioning (ASHRAE) and, as a chair or voting member on several of ASHRAE's technical committees, he is contributing to developing/advancing building codes and standards. Beside fellowships and awards, his research and advising work has been well recognized in academia as many of his PhD students have received prestigious positions at universities with top programs in building energy and environment related fields. Marina Vance, PhD Dr. Marina Vance is an Assistant Professor in the Department of Mechanical Engineering with a courtesy appointment in the Environmental Engineering Program at the University of Colorado Boulder. Her research is focused on applying engineering tools to better understand and minimize human exposure to novel environmental contaminants from everyday activities and the use of consumer products. Her group focuses on the physical and chemical characterization of ultrafine aerosols, or nanoparticles in air. Before joining CU Boulder, she was the Associate Director of the Virginia Tech Center for Sustainable Nanotechnology (VTSuN) and Deputy Director of the VT National Center for Earth and Environmental Nanotechnology Infrastructure (NanoEarth). Dr. Vance received her PhD in Civil and Environmental Engineering from Virginia Tech in 2012 for studying the release of nanomaterials, especially silver nanoparticles, from the use of everyday consumer products. She received her Bachelor's and Master's degrees in Environmental Engineering by the Universidade Federal de Santa Catarina (Florianópolis, Brazil).
Welcome to another episode of Biotechnology Focus radio. This week we are discussing some of the recent mergers and acquisitions that have been rocking the headlines, some recently awarded grants and how machines are moving fast. I am your host Michelle Currie, here to bring you the lowdown on the Canadian biotech scene. +++++ Celgene, a biotech giant, has merged with and acquired Juno Therapeutics and their leading blockbuster drug cancer therapy in one of their largest deals ever. For a total of $9 billion, Celgene will pay $87 a share in cash for those not already owned by this corporation. Celgene and Juno have been collaborating since June 2015 under which the two companies would leverage T cell therapeutic strategies to develop treatments for patients with cancer and autoimmune diseases with an initial focus on CAR-T and TCR technologies. In April 2016, Celgene exercised its option to develop and commercialize the Juno CD19 program outside of North America and China. Juno develops cell-based cancer immunotherapies based on chimeric antigen receptor and high-affinity T cell (CAR-T cell) receptor technologies to genetically engineer T cells to recognize and kill cancer. Several product candidates have shown compelling clinical responses in clinical trials in refractory leukemia and lymphoma conducted to date. This acquisition will position Celgene to become a preeminent cellular immunotherapy company with a platform to be at the forefront of future advances. JCAR017, a pivotal stage asset, with an emerging favorable profile in DLBCL, is expected to add approximately $3 billion in peak sales and significantly strengthen Celgene’s lymphoma portfolio, and JCARH125 will enhance Celgene’s campaign against BCMA (B-cell maturation antigen), a key target in multiple myeloma. +++++ The global pharma industry is undergoing a dramatic transition from a quest for blockbusters to the design of a precision medicine based drug design. Artificial intelligence is one of the most prominent elements that has been adopted as part of the transition from a fully integrated pharmaceutical company model of drug design to extensive interaction with smaller innovative R&D companies as well as academic institutions. Artificial Intelligence (AI) is the activity devoted to making machines intelligent, and intelligence is that quality that enables an entity to function appropriately and with foresight in its environment (definition proposed by Nils J. Nillson, Stanford U.). Even though there are numerous definitions for AI, this one fits nicely into the goal of using machine learning for improving the rate of success in the design of novel and cost-effective therapeutics. One of the primary reasons that AI has such a great potential in drug development is that there is a huge amount of health data available right now in the public health system. Clinical trials’ data, electronic medical records (EMR), genetic profiles and much more is the wealth representing the notion of BIG DATA in healthcare. The main challenge regarding the processing of big data is the need to process it in a meaningful and cost-effective fashion. That is why training a machine to fulfill the task becomes so attractive. Selecting and adjusting the right algorithms is the first essential step but once it is in place, training machines to find optimal patterns between the structure of “druggable molecules” and their optimal activity is within reach. Canada has established a leadership position in training of machines to learn how to perform complex tasks, in a relatively short period of time. Based on recent commitments to the space, it is expected that we will witness in the foreseeable future designs of novel and much more specific therapeutics with higher potency and lesser side effects. The prospects are quite encouraging in light of the shift global pharma industry is adopting towards precision medicine. That shift will rely on sifting through patients’ medical records. Canadian AI machines are learning fast and are expected to become a key player in advancing academic concepts into standard and streamlined processes and organizations. In Ontario, the University of Toronto has emerged as a world-leading hub for research and entrepreneurship in this area. A potent combination of long-standing academic research in conjunction with the adoption of machine learning methodologies have already proven to be game-changing opportunities. Interactive approaches to computer science and medical research, combined with emerging best in class entrepreneurship programming and training is already yielding some fascinating fruits in the area of AI for drug discovery. Companies like Structura Bio are taking the complex computational challenge of reducing noisy images from cryo-electron microscopes into readable highly accurate 3D structures of proteins and are doing what used to take a server room filled with computers a week, in a matter of seconds. Similarly, Phenomic AI (a recently incorporated UTEST company) uses a technique called deep learning to analyze data from high-throughput phenomic screens to analyze cell and tissue phenotypes in microscopy data with incredible accuracy. It holds out the potential for eliminating human intervention in the assessment of all that data. In some cases, companies like Deep Genomics and Atomwise are going all the way by leveraging their respective AI technologies to become drug discovery engines themselves. Our awareness of the impact of the AI revolution in drug discovery is already enormous and we’re only at the beginning of its adoption cycle. Future advances in Canada will be buoyed further by strong academic and institutional foundations that have been put in place to assist Canada in sustaining this advantage. The Vector Institute, as an example, was established in 2017 in partnership with Canada’s largest companies and the Federal and Provincial Government’s to attract and retain world-leading research talent and to promote cutting-edge research in the field. Recently, partnerships have been established between the MaRS Innovation research healthcare ecosystem (UHN, Sickkids, Sunnybrook) with global players in the space of machine learning based drug design and developments. Partnerships with Schrödinger and Evotec have been established to capture the enormous potential of “fishing in the pond” of EMR’s rich source of unraveling the tissue/cellular architecture as a baseline for the discovery of novel disease targets, which thereby establishes a mechanism for better drugs. The field of AI in the service of medical research is still in its infancy, but the initial avalanche of results is already starting to give us an idea of the great potential that machine learning can offer to those embarking on advancing drug development. Reducing screening times, aiding new drug candidates and finding the most effective drugs for specific diseases at a speed that humans cannot achieve is compelling, and we believe that AI will increasingly become part of the medical landscape. Once hurdles such as data standardized collection and storage as well as data privacy concerned are addressed, it is expected that we will witness an exponential inclination in the implementation of machine learning as a powerful tool in the design of more potent drugs with lesser side-effects. The FDA and Health Canada are encouraging pharmaceutical companies to join the choir. To conclude, rephrasing from Eric Topol of the Scripps Research Institute (CNBC, May 2017), “The potential of artificial intelligence has probably the biggest impact of any type of technology on healthcare.” +++++ Two of Canada’s largest producers of cannabis have struck a deal after months of negotiations and a hostile takeover bid. The board of directors and the special committee of the CanniMed board have agreed to support a new offer made by Aurora for the acquisition of all of the issued and outstanding shares of CanniMed not owned by Aurora. Terry Booth, the CEO of Aurora Cannabis says, “We are very pleased to have come to terms with CanniMed on this powerful strategic combination that will establish a best-in-class cannabis company with operations across Canada and around the world.” The new offer for CanniMed is approximately $1.1 billion based on Aurora’s implied share price of $12.65. The maximum amount of cash available under the amended offer will be $140 million, and the number of Aurora shares to be issued will be between approximately 72 million and 84 million. Assuming maximum cash elections, each CanniMed shareholder would receive $5.70 in cash and 2.9493 Aurora shares. Despite CanniMed filing a law suit against Aurora earlier this month, this deal provides the optimum outcome for both companies. +++++ The Ottawa Hospital has been awarded $12.7 million in the most recent project grant competition from the Canadian Institutes of Health Research (CIHR). The grant funding will be going to sixteen research groups at the hospital who are in affiliation with the University of Ottawa. This represents an enormous success rate of 30 per cent, doubling the national average. The new funding will provide researchers the much-needed capital to delve deeper into their studies ranging on a plethora of subjects – anywhere from oncolytic viruses as immunotherapy treatments, using a holistic approach to improving the quality of life for the homeless, to understanding the role of liquid metabolism in the brain. “I’m delighted that our researchers have once again achieved such a high success rate,” says Dr. Duncan Stewart, executive vice president of research at The Ottawa Hospital and professor of medicine at the University of Ottawa. “These new research projects have the potential to redefine the future of health-care, both at home and around the world.” The Ottawa Hospital has scored above the national average in CIHR grant competitions for the past several years, including 2015, 2016, and 2017. This research centre shows great promise and innovative studies for the years ahead. For the summaries of all the projects please visit biotechnologyfocus.ca +++++ Well that wraps up another episode of Biotechnology Focus radio. If you have any questions, comments or story ideas, please contact us at press@promotivemedia.ca, and don’t forget to follow us on our twitter handle @BiotechFocus. From my desk to yours – this is Michelle Currie.
My guest today is the former business development manager of uTest, community advocate, and serial social entrepreneur. Back in 2014, she came up with the idea to build a platform to empower Community Managers around the world. Needing help with the tech side of things, she began the quest for a tech co-founder, which she found and they began planning, raising money, and building. Today, Mobilize serves as an online hub for over 1,000 communities and 1,000,000 members. This is a fascinating conversation where we discuss creating compelling reasons to buy, why everything has an element of community, and honing a vision. Now, let’s hack… Sharon Savariego.
My guest this week is Matt Johnston, Chief Executive Officer of Mautic, the leader in open source marketing automation. Mautic makes it easy for you to put the right message in front of the right person at the right time, empowering enterprises and agencies with a flexible, open platform built for us by us. Before joining Mautic earlier this year Matt was the Chief Marketing and Strategy Officer at Applause (formerly known as uTest). An integral part of Applause’s growth after joining in late 2008, Matt led that company’s marketing, community management, partner channel, and company strategy, helping it become one of Boston’s most highly regarded enterprise technology players. Before that he played a range of senior and strategic marketing roles at OnForce, Mimeo, and Herman Miller office furniture. Our second segment this week is a real treat for anyone interested in what it means to be a Chief Marketing Officer in 2017. Matt and I together have held just about every marketing role you can have, including the one at the top, and our conversation covered everything from the anxiety and stress of keeping up with the latest technology phenom du jour to the roots, current reality, and future of the latest and greatest Account Based Marketing (ABM) model. It’s always fun to trade war stories with another senior marketing guy, and you’ll be a fly on the wall for a conversation I know we both really enjoyed. How Hard Can It Be is sponsored by G20 Ventures, early traction capital for East Coast enterprise tech startups, backed by the power and expertise of 20 of the Northeast's most accomplished entrepreneurs. G20 Ventures... People first. How Hard Can It Be is also sponsored by Actifio, the world’s leading Enterprise Data-as-a-Service platform. Deliver your data just like your applications and infrastructure... as a service available instantly, anywhere. For hybrid cloud, faster DevOps, and better business resiliency, Actifio is Radically Simple.
My guest today is a writer, marketer, and an entrepreneur. After spending a few years as Content (and Senior Content) Manager at uTest, my guest decided to step out on his own as a content and copywriter. While landing his first few clients, he realized he had created a unique way to pitch his work to potential clients. This new method was so effective he almost immediately began hiring writers to fulfill the demand he was generating. This was the birth of nDash Marketing. My guest continued to grow nDash Marketing for three years until he could no longer hire writers fast enough. This further demand leads him to turn his agency into nDash.co, a platform for writers to earn work by pitching brands unique content ideas. Now, let’s hack… Michael Brown.