Podcasts about ancova

This episode's guest is Bryan Sansbury the CEO of AEGIS Hedging. If you haven't heard the news, AEGIS recently acquired my energy company Ancova.  This was a massive life event for me and my co-founder. We started the business 10 years ago as a bootstrapped advisory business that transformed into a commodity marketing and technology firm that disrupted our niche of the industry. This episode we discuss the genesis of the merger, why the firms fit together, and what we are hoping to accomplished with the combined firm. I know I have been on a break releasing new episodes the last few months but this deal was taking up a ton of my time! I'm going to start releasing episodes on a more frequent schedule moving forward. Hope you enjoy the show! Press release on the merger: https://www.businesswire.com/news/home/20240116717809/en/AEGIS-Hedging-Acquires-Ancova-Energy

This episode's guest is Taylor Jones with Techvestor, a large scale vacation home short term rental fund. Taylor is always posting some amazing STR content on Twitter showing his company's properties and the strategies they use to scale a fast growing STR fund. This episode we discuss what Taylor looks for in a market before investing in short term rentals. We dive into how his company has been able to scale quickly and what advantages that scale brings to his investors. We talk about the challenges of managing properties remotely and the type of team it takes to efficiently manage their portfolio. We then cover what Taylor looks for in a property and how different elements like amenities, lot quality, floor plans, and uniqueness can make a huge difference on profitability. Lastly, we discuss the future of the STR asset class and how Taylor sees it evolving over time. Hope you enjoy the show! Ancova website: https://www.ancova.com  Our Broken Bow Development: https://www.mountainforkresort.com Our Broken Bow Cabin Rentals: https://mountainforkvacations.com/  Max's Twitter: https://twitter.com/max_gagliardiPodcast Twitter: https://twitter.com/Always_Building

This episode's guest is Mike Singleton, the founder of Invictus Research, a macro research firm. He regularly puts out great macro videos talking about what is going on in the markets.This episode we discuss the recent macro numbers coming out and what it means for the economy. We talk about the Fed and get Mike's view on interest rates and inflation. Lastly, we dive into the equities markets, energy/commodities and Bitcoin. Hope you enjoy the show! Ancova website: https://www.ancova.com/ Our Broken Bow Development Website: https://www.mountainforkresort.com/   Max's Twitter: https://twitter.com/max_gagliardiPodcast Twitter: https://twitter.com/Always_Building

This episode I had on two of the Rockstars that work for Ancova (our energy business) to discuss our new Commercial Management Platform "Ancova View."We discuss the complexities of selling oil, natural gas, and NGLs, and how there is a data problem when processing these sales. We talk about commercial contract side of the business and why these agreements are complicated and difficult to administer. Lastly, we run through the different tools we have built in Ancova View and how they are helping our clients. If you are interested in the process of how energy is monetized, and the tools we are building to help streamline the process, I think you will find value in the conversation. Hope you enjoy the show!Ancova website: ancova.com Our Broken Bow Development Website: MountainForkResort.com  Max's Twitter: https://twitter.com/max_gagliardiPodcast Twitter: https://twitter.com/Always_Building

This episode's guest is a special one, my business partner and co-founder of Ancova, Mark Edge. I'd been twisting Mark's arm to come on the podcast for 2 years, and he finally made an appearance! Mark and I founded the company almost 9 years ago, and prior to that we worked together at Chesapeake Energy. So for the better part of the last 12 years he has been a mentor and influential person in my life and career. This episode we recap Mark's career and he tells stories of his time at CHK and the ups and downs of the oil and gas industry. We talk about entrepreneurship and the challenges we've faced, as well as the good fortune we've had to make a living in this volatile business. We talk about the challenges of scaling a business, the failures and successes, working with great people, and how lucky we have been to get to work in a niche segment in one of the greatest industries in the world, oil and gas. Hope you enjoy the show! Our company's website: www.ancova.comMax's Twitter: https://twitter.com/max_gagliardiPodcast Twitter: https://twitter.com/Always_Buildingtiktok: https://www.tiktok.com/@max.gagliardiYouTube: https://www.youtube.com/@max_gagliardi

Greetings & welcome back to the rose bros podcast.This episode we are joined by Max Gagliardi - co-founder of the Ancova  group of companies (ancova.com | ancova.io).  Prior to forming Ancova in 2014, Mr. Gagliardi held commercial and financial roles at multiple corporations. He has participated in a variety of roles on deal teams for over $16 billion in M&A transactions across the Energy Industry.Max hosts Always Be Building Podcast focused on business, entrepreneurship, the markets, and Max's personal interests.   Max has a BS and MBA from Oklahoma State University, he is a lifelong resident of Oklahoma and currently lives in Edmond with his wife and three sons.Among other things we discussed lessons from late energy billionaire Aubrey McClendon, why US isn't growing, the future of energy & why it never pays to bet against America. Enjoy! This podcast episode is sponsored by Connate Water Solutions.Do you need cost effective water sourcing options to supply your next drilling or completions program?Connate Water Solutions is a specialized hydrogeology company focused on water well drilling, testing and water management services in Western Canada and Texas.Contact info@connatewater.com or www.connatewater.com for more details.This podcast is sponsored by Headracingcanada.comLooking for high performance ski gear this winter? In partnership with 4x-Olympian Manny-Osborne Paradis, Headracingcanada.com is offering the lowest prices possible through its online storefront, by passing brick and mortar savings to customers. Check out  Headracingcanada.com for more info on high performance gear for the upcoming ski season.       Support the show

Max Gagliardi (Managing Partner) & Mike Wright (Director - BD) from Ancova Energy join the podcast to walk through how NonOp owners can take their interests in-kind in order to help lower their midstream marketing costs, while also gaining additional access & transparency to pricing data. A big thanks to our 2 Minerals & Royalties Podcast Sponsors: --Opportune: For more information on Opportune's back office & outsourcing services, then please visit www.opportune.com --Noble Royalties: To explore ways to do deals w/ Noble, please email Chase Morris at cmorris@nobleroyalties.com or Shannon Manner smanner@nobleroyalties.com

FRIENDS AND ENEMIES Thanks for coming back for another episode of The Canadian Bitcoiners Podcast. Powered by Shakepay! Receive $10 CAD on your first deposit of $100 CAD. Shakepay is the service we use to buy Bitcoin, and there isn't an easier way to start your stack! And Ledn.io! We use Ledn as a way to earn a nice chunk of Bitcoin interest on our BTC, and they offer loans, B2X and other services as well - check them out! Earn 10 USDC when you deposit and hold a minimum of 75 USDC or 150K satoshis! This week we have for you A ROCK SOLID interview with Ancova's Max Gagliardi. Max also hosts the Talk Energy Podcast, and once you make it through this rip you'll see why. Max delivers a tour de force on the issues with energy policy, what it means to be green, what we can do to fix the situation, where Bitcoin mining and energy have room to operate together, and whether Russell Westbrook is a great Oklahoma athlete. We thank Max for his time and we'll definitely be inviting him back. Take care, enjoy your weekend! --- Send in a voice message: https://anchor.fm/canadian-bitcoiners/message

Co-Founder of Ancova and host of the Talk Energy Podcast Max Gagliardi, Joe Burnett, and Will Clemente discuss global energy markets, Bitcoin mining, and more! Buy Bitcoin and crypto with zero fees on FTX (http://ftx.blockwareintelligence.com/). Use our referral code (Blockware) and get a free coin when you trade $10 worth. Follow us on Twitter: https://twitter.com/WClementeIII https://twitter.com/Blockwareteam https://twitter.com/max_gagliardi

This episode's guests are Mike Wright and Chris Sorrels. I worked with Mike & Chris back in the Chesapeake Energy days and we have stayed in touch over the years. Recently they joined the Ancova Energy team to help on the Business and Corporate front. This episode we reminisce about the good old days at CHK.  We talk about the state of the oil and gas midstream market and the challenges it has faced the last few years. Lastly, we talk about Mike and Chris joining the Ancova team and some of the initiatives we are working on for the future of the company. Hope you enjoy the show! Talk.Energy Podcast: https://talk.energy/ Twitter: https://twitter.com/max_gagliardi Twitter: https://twitter.com/talkenergypodLinkedIn: https://www.linkedin.com/company/talkenergy YouTube: https://www.youtube.com/c/TalkEnergyPodcast

Deze keer opnieuw ANOVA maar nu kijken we naar wat er gebeurt als we meer dan 1 factor in ons model hebben. Two-way ANOVA, three-way ANOVA, within-subjects, between-subjects, mixed designs, zijn termen die voorbij komen. Ik leg uit dat ANOVA uiteindelijk neerkomt op lineaire regressie, en wat de 'CO' is in ANCOVA.

Investigating the anti-hypertensive effects of pumpkin seed oil Marymount University and University of Guilan (Iran), September 29, 2021 In a study, researchers from Iran and the U.S. found that pumpkin seed oil can potentially treat hypertension in postmenopausal women. Their report was published in Complementary Therapies in Clinical Practice. Postmenopausal women are more likely to develop hypertension than men of the same age. In vivo studies reveal that pumpkin seed oil has anti-hypertensive activity. The team investigated the effects of pumpkin seed oil supplementation on vascular function and heart rate variability in postmenopausal women with elevated blood pressure. Participants were assigned to take either a pumpkin seed oil supplement or a placebo for the six-week study. Those in the experimental group took 3 grams of pumpkin seed oil every day. Brachial and central blood pressure, wave reflection (augmentation index, AIx), arterial stiffness (SI) and various HRV parameters were measured at baseline and at the end of the study. Those who took pumpkin seed oil had significantly lower AIx, brachial and systolic blood pressure after treatment. SI and HRV parameters remained unchanged for the treatment group and the placebo group at the end of the study. In sum, taking pumpkin seed oil may improve arterial hemodynamics in postmenopausal women.     Health benefits of evening classes revealed   Oxford University, September 20, 2021    Those with a taste for adult education classes have long known it, but now Oxford University scientists have confirmed that taking part in the weekly sessions can boost wellbeing – regardless of the subject studied.   In partnership with the Workers' Educational Association (WEA), the largest voluntary sector provider of adult education in England and Scotland, a team from Oxford's department of experimental psychology studied attendees at seven separate day-time adult education classes. Their findings are published in a series of papers.   Each class took place over seven months and included a break in the middle. Attendees completed questionnaires before and after their class three times over the seven months: at the beginning of their courses, after 3 months, and at the end of the seven months. Participants were involved in one of three activities: singing, crafts or creative writing.   Overall, attendees at all seven classes had improved mental and physical health and reported more satisfaction with their lives at the end of their courses.   Dr Eiluned Pearce led the research. She said: 'The students reported benefits including increased self-confidence, a greater feeling of control over their lives and more willingness to take on new challenges. Some said the classes made them more motivated to be more active, despite the classes not specifically involving physical activity.   'Participants also said that the classes broadened their networks of friends and gave them an increased sense of belonging. We also found that the more someone felt part of their group, the more their health and wellbeing improved.' An intriguing finding was in the singing and creative writing classes. Building on the results of an earlier paper from the same study, which found that people in singing classes felt closer to their group more quickly than those in the other classes, the team looked at how relationships formed between individuals in the classes.   Each person was asked to name those other people in the class whose name they could remember, whether or not they felt connected to each person they named, and whether they had talked to that person during class.   Dr Pearce said: 'The results showed that those in the singing and creative writing groups built up relationships with other individuals more quickly than the crafters, and singers felt more connected to the class as a whole more quickly than both the other groups. 'While this confirms our earlier finding that singing has an 'ice-breaker effect' compared to other activities, it shows that other activities may enable people to increase their social networks just as much, even if it takes them longer to feel connected to their group as a whole.'   Co-author Dr Jacques Launay adds: 'While much of our previous work has demonstrated the importance of music, it is likely that the most socially bonding activities are always those that are personally chosen and enjoyed. This research adds to growing support for the relevance of creative activities in creating happy communities and improving health and well-being, with consequent benefits for public services and society.'   Dr Pádraig Mac Carron, Dr Anna Machin and Professor Robin Dunbar were also involved in the research.   Howard Croft, WEA Regional Education Manager, said: 'The findings reiterate the feedback that we have had from our students over the years: learning is a fantastic way to boost your self-esteem and confidence. Also of note, is its therapeutic effect. For many students, creative courses are a means of finding a new outlet for expressing their feelings. This can be of immense help during times of personal difficulty or emotional upheaval, such as divorce or bereavement. Simply going to a course can offer much-needed respite.   'For others, learning can be an opportunity to reignite a former passion. This could be anything from a subject which you enjoyed at school to an area which you are interested in. Whatever your reason, there are so many benefits to be gained by signing up to a course.'       Want to live forever? Theoretically, you could, study says Swiss Federal Institute of Technology, September 29, 2021 Humans can probably live to at least 130, and possibly well beyond, though the chances of reaching such super old age remain vanishingly small, according to new research. The outer limit of the human lifespan has long been hotly debated, with recent studies making the case we could live up to 150 years, or arguing that there is no maximum theoretical age for humans. The new research, published Wednesday in the Royal Society Open Science journal, wades into the debate by analyzing new data on supercentenarians—people aged 110 or more—and semi-supercentenarians, aged 105 or more. While the risk of death generally increases throughout our lifetime, the researchers' analysis shows that risk eventually plateaus and remains constant at approximately 50-50. "Beyond age 110 one can think of living another year as being almost like flipping a fair coin," said Anthony Davison, a professor of statistics at the Swiss Federal Institute of Technology in Lausanne (EPFL), who led the research. "If it comes up heads, then you live to your next birthday, and if not, then you will die at some point within the next year," he told AFP. Based on the data available so far, it seems likely that humans can live until at least 130, but extrapolating from the findings "would imply that there is no limit to the human lifespan," the research concludes. The conclusions match similar statistical analyses done on datasets of the very elderly. "But this study strengthens those conclusions and makes them more precise because more data are now available," Davison said. The first dataset the team studied is newly released material from the International Database on Longevity, which covers more than 1,100 supercentenarians from 13 countries. The second is from Italy on every person who was at least 105 between January 2009 and December 2015. 'One in a million' The work involves extrapolating from existing data, but Davison said that was a logical approach. "Any study of extreme old age, whether statistical or biological, will involve extrapolation," he said. "We were able to show that if a limit below 130 years exists, we should have been able to detect it by now using the data now available," he added. Still, just because humans can theoretically reach 130 or beyond, doesn't mean we're likely to see it anytime soon. For a start, the analysis is based on people who have already achieved the relatively rare feat of making it to well over 100. And even at age 110, your chances of making it to 130 are "about one in a million... not impossible but very unlikely," said Davison. He thinks we could see people reaching 130 within the century, as more people make it to supercentenarian status, increasing the chances of one becoming that one in a million. "But in the absence of major medical and social advances, ages much over this are highly unlikely ever to be observed," he added. For now, the oldest person on record is Frenchwoman Jeanne Calment, who died in 1997 at the confirmed age of 122. Her true age was the subject of some controversy, with claims of a possible fraud, but in 2019 several experts said a review of the evidence confirmed her age. Other pretenders to the throne of oldest person ever have a long way to go. The oldest verified living person in the world is Japan's Kane Tanaka, a comparatively youthful 118.     Psychological treatment shown to yield strong, lasting pain relief, alter brain networks University of Colorado, September 29, 2021 Rethinking what causes pain and how great of a threat it is can provide chronic pain patients with lasting relief and alter brain networks associated with pain processing, according to new University of Colorado Boulder-led research. The study, published Sept. 29 in JAMA Psychiatry, found that two-thirds of chronic back pain patients who underwent a four-week psychological treatment called Pain Reprocessing Therapy (PRT) were pain-free or nearly pain-free post-treatment. And most maintained relief for one year. The findings provide some of the strongest evidence yet that a psychological treatmentcan provide potent and durable relief for chronic pain, which afflicts one in five Americans. "For a long time we have thought that chronic pain is due primarily to problems in the body, and most treatments to date have targeted that," said lead author Yoni Ashar, who conducted the study while earning his Ph.D. in the Department of Psychology and Neuroscience at CU Boulder. "This treatment is based on the premise that the brain can generate pain in the absence of injury or after an injury has healed, and that people can unlearn that pain. Our study shows it works." Misfiring neural pathways Approximately 85% of people with chronic back pain have what is known as "primary pain," meaning tests are unable to identify a clear bodily source, such as tissue damage. Misfiring neural pathways are at least partially to blame: Different brain regions—including those associated with reward and fear—activate more during episodes of chronic pain than acute pain, studies show. And among chronic pain patients, certain neural networks are sensitized to overreact to even mild stimuli. If pain is a warning signal that something is wrong with the body, primary chronic pain, Ashar said, is "like a false alarm stuck in the 'on' position." PRT seeks to turn off the alarm. "The idea is that by thinking about the pain as safe rather than threatening, patients can alter the brain networks reinforcing the pain, and neutralize it," said Ashar, now a postdoctoral researcher at Weill Cornell Medicine.or the randomized controlled trial, Ashar and senior author Tor Wager, now the Diana L. Taylor Distinguished Professor in Neuroscience at Dartmouth College, recruited 151 men and women who had back pain for at least six months at an intensity of at least four on a scale of zero to 10. Those in the treatment group completed an assessment followed by eight one-hour sessions of PRT, a technique developed by Los Angeles-based pain psychologist Alan Gordon. The goal: To educate the patient about the role of the brain in generating chronic pain; to help them reappraise their pain as they engage in movements they'd been afraid to do; and to help them address emotions that may exacerbate their pain.  Pain is not 'all in your head' "This isn't suggesting that your pain is not real or that it's 'all in your head'," stressed Wager, noting that changes to neural pathways in the brain can linger long after an injury is gone, reinforced by such associations. "What it means is that if the causes are in the brain, the solutions may be there, too." Before and after treatment, participants also underwent functional magnetic resonance imaging (fMRI) scans to measure how their brains reacted to a mild pain stimulus. After treatment, 66% of patients in the treatment group were pain-free or nearly pain-free compared to 20% of the placebo group and 10% of the no-treatment group. "The magnitude and durability of pain reductions we saw are very rarely observed in chronic pain treatment trials," Ashar said, noting that opioids have yielded only moderate and short-term relief in many trials. And when people in the PRT group were exposed to pain in the scanner post-treatment, brain regions associated with pain processing—including the anterior insula and anterior midcingulate —had quieted significantly. The authors stress that the treatment is not intended for "secondary pain"—that rooted in acute injury or disease. The study focused specifically on PRT for chronic back pain, so future, larger studies are needed to determine if it would yeild similar results for other types of chronic pain.  Meanwhile, other similar brain-centered techniques are already ememrging among physical therapists and other clinicians who treat pain. "This study suggests a fundamentally new way to think about both the causes of chronic back pain for many people and the tools that are available to treat that pain," said co-author Sona Dimidjian, professor of psychology and neuroscience and director of the Renee Crown Wellness Institute at CU Boulder. " It provides a potentially powerful option for people who want to live free or nearly free of pain."     Citicoline (CDP-choline) and Memory Function in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial  Kyowa Hakko Bio (Japan), September 2021 Supplementation of citicoline (CDP-choline), a naturally occurring mononucleotide, has shown beneficial effects on memory function and behavior in populations with a wide range of impairments. However, few studies have investigated its effect in healthy older populations. Objective The objective of this study was to investigate the effects of citicoline, on memory in healthy elderly populations with age-associated memory impairment (AAMI). Methods A total of 100 healthy men and women aged between 50 and 85 y with AAMI participated in this randomized, double-blind, placebo-controlled trial. Participants were randomized to receive placebo (n = 51) or citicoline (n = 49; 500 mg/d) for 12 wk. Memory function was assessed at baseline and end of the intervention (12 wk) using computerized tests (Cambridge Brain Sciences, Ontario, Canada). Safety measurements included adverse events query, body weight, blood pressure, and hematology and metabolic panel. Intent-to-treat analysis was conducted using ANCOVA for the primary and secondary outcome variables with Bonferroni correction for multiple comparisons. Results A total of 99 out of 100 participants completed the study in its entirety. After the 12-wk intervention, participants supplemented with citicoline showed significantly greater improvements in secondary outcomes of episodic memory (assessed by the Paired Associate test), compared with those on placebo (mean: 0.15 vs. 0.06, respectively, P = 0.0025). Composite memory (secondary outcome), calculated using the scores of 4 memory tests, also significantly improved to a greater extent following citicoline supplementation (mean: 3.78) compared with placebo (mean: 0.72, P = 0.0052). Conclusions Dietary supplementation of citicoline for 12 wk improved overall memory performance, especially episodic memory, in healthy older males and females with AAMI. The findings suggest that regular consumption of citicoline may be safe and potentially beneficial against memory loss due to aging.      Sleep may strengthen long-term memories in the immune system   University of Tuebingen (Germany) September 29, 2021   More than a century ago, scientists demonstrated that sleep supports the retention of memories of facts and events. Later studies have shown that slow-wave sleep, often referred to as deep sleep, is important for transforming fragile, recently formed memories into stable, long-term memories. Now, in an Opinion article published  in Trends in Neurosciences, part of a special issue on Neuroimmunology, researchers propose that deep sleep may also strengthen immunological memories of previously encountered pathogens.   "While it has been known for a long time that sleep supports long-term memoryformation in the psychological domain, the idea that long-term memory formation is a function of sleep effective in all organismic systems is in our view entirely new," says senior author Jan Born of the University of Tuebingen. "We consider our approach toward a unifying concept of biological long-term memory formation, in which sleep plays a critical role, a new development in sleep research and memory research."   The immune system "remembers" an encounter with a bacteria or virus by collecting fragments from the bug to create memory T cells, which last for months or years and help the body recognize a previous infection and quickly respond. These memory T cells appear to abstract "gist information" about the pathogens, as only T cells that store information about the tiniest fragments ever elicit a response. The selection of gist information allows memory T cells to detect new pathogens that are similar, but not identical, to previously encountered bacteria or viruses.   Studies in humans have shown that long-term increases in memory T cells are associated with deep slow-wave sleep on the nights after vaccination. Taken together, the findings support the view that slow-wave sleep contributes to the formation of long-term memories of abstract, generalized information, which leads to adaptive behavioral and immunological responses. The obvious implication is that sleep deprivation could put your body at risk.   "If we didn't sleep, then the immune system might focus on the wrong parts of the pathogen," Born says. "For example, many viruses can easily mutate some parts of their proteins to escape from immune responses. If too few antigen-recognizing cells [the cells that present the fragments to T cells] are available, then they might all be needed to fight off the pathogen. In addition to this, there is evidence that the hormones released during sleep benefit the crosstalk between antigen-presenting and antigen-recognizing cells, and some of these important hormones could be lacking without sleep."   Born says that future research should examine what information is selected during sleep for storage in long-term memory, and how this selection is achieved. In the end, this research could have important clinical implications.   "In order to design effective vaccines against HIV, malaria, and tuberculosis, which are based on immunological memory, the correct memory model must be available," Born says. "It is our hope that by comparing the concepts of neuronal and immunological memory, a model of immunological memory can be developed which integrates the available experimental data and serves as a helpful basis for vaccine development."         Standardized astragalus extract for attenuation of the immunosuppression induced by strenuous physical exercise: randomized controlled trial University of Physical Sciences (Poland), September 3, 2021 This paper aimed to verify how a supplementation of rower's diet with Astragalus Membranaceus Root (AMR) modulated their immune system response to maximal physical exertion. Methods The double-blind study included 18 members of the Polish Rowing Team assigned to the supplemented group (n = 10), and the placebo group (n = 8). The participants performed a 2000 m test on a rowing ergometer at the beginning and at the end of the six-week of intensive training camp during which the supplemented group received 500 mg of AMR. Blood samples were obtained prior to, 1 min after completing, and 24 h after the exertion test. The levels of interleukin 2 (IL2), interleukin 4 (IL4), interleukin 10 (IL10), interferon ɤ (IFN-ɣ), and lactic acid were determined. Subpopulations of T regulatory lymphocytes [CD4+/CD25+/CD127−] (Treg), cytotoxic lymphocytes [CD8+/TCRαβ+] (CTL), natural killer cells [CD3−/CD16+/CD56+] (NK), and TCRδγ-positive cells (Tδγ) were determined with flow cytometry. Results After the camp, the initial NK and Treg levels sustained at the baseline, while Tδγ counts increased relative to the levels in the placebo group. In the supplemented subgroup, a decrease in IL2 level in reaction to maximal exertion clearly deepened while the change in IL-2/IL-10 level induced by the recovery after this exertion clearly increased, relative to the changes in the placebo group. Conclusions AMR restored the immunological balance in strenuously trained athletes through a stabilization of NK and Treg cells with a positive trend in Tδγ towards Th1 response during restitution by cytokine IL2 modulation.

Patrick and Greg talk about the potential advantages and disadvantages of alternative approaches to analyzing two time-point data. They discuss traditional models for raw and residualized change scores, and describe how each of these remains baked into the soul of contemporary models for repeated measures data. Along the way they also mention: 24 inch pizza pans, movie fails, being otherwise sophisticated, beer bongs, witches, third grade math, emails from PETA, glorious histories, hairy eyeballs, and who do I see about that. 

Researchers study preventing cancer and diabetes with the maqui berry NOVA Southeastern University of Florida, May 27, 2021 Aristotelia chilensis, also known as maqui berry, is a fruit-bearing shrub native to South America.  According to a study published in the journal Phytochemical Analysis, maqui berries are rich in anthocyanins, which give the fruits their dark purple color. Anthocyanins are plant pigments that possess many remarkable biological properties, such as antioxidant, anti-inflammatory, anti-viral and anti-cancer activities. In a recent study, researchers at NOVA Southeastern University in Florida discussed the potential of Chilean maqui berry for use as a nutritional supplement that can help treat hyperinsulinemia and related diseases. Hyperinsulinemia, or higher-than-normal insulin levels, is often caused by insulin resistance, which is said to be the precursor to diabetes. Chronic hyperinsulinemia also promotes cancer growth by allowing insulin to exert its oncogenic effects, which include enhancing growth factor-dependent cell proliferation, among others. The researchers discussed how Chilean maqui berry can help with insulin resistance and reduce cancer risk in an article published in the journal Food Science and Human Wellness. The medicinal benefits of Chilean maqui berry Researchers have long considered nutritional supplementation to be a possible alternative or adjunct treatment to conventional therapies for common ailments and diseases. According to recent studies, maqui berries can reduce postprandial insulin levels by as much as 50 percent and are just as effective as metformin at increasing insulin sensitivity and stabilizing blood glucose levels. Maqui berries’ mechanism of action involves inhibiting sodium-dependent glucosetransporters in the small intestine and slowing the rate of entry of glucose in the bloodstream. Thanks to these actions, maqui berries can effectively reduce the likelihood of blood sugar spikes and prevent the corresponding rise in insulin levels that follows.  At the same time, maqui berries contribute to cancer prevention since chronically high blood glucose levels — besides chronic hyperinsulinemia — are also linked to the development of cancer. In fact, numerous studies have shown that diabetics and prediabetics have an elevated risk of developing cancerous growths. Based on the findings of previous studies, the researchers believe that consistent supplementation with Chilean maqui berries could indirectly reduce the risk of cancer and other diseases that are promoted by hyperglycemia (high blood sugar) and hyperinsulinemia.     Studies reveal that social isolation and quarantine throughout the COVID-19 pandemic may have a detrimental impact on physical and mental health of people living with pre-existing conditions University of Naples (Italy) and Teva Pharmaceuticals, May 30, 2021   Abstract 803: Impact of social isolation and quarantine on the course of diabetes mellitus and its complications during Covid 19 pandemic in Adjara Region Country of Georgia Abstract 1337: Psychological distress in patients with hypocortisolism during mass quarantine for Covid-19 epidemic in Italy Studies reveal that social isolation and quarantine throughout the COVID-19 pandemic may have a detrimental impact on people living with pre-existing conditions.  Social isolation and quarantine can have a detrimental impact on physical and mental health of people living with pre-existing conditions, according to two studies being presented at the 23rd European Congress of Endocrinology (e-ECE 2021)  The studies bring together research on the impact of social isolation and quarantine for people living with diabetes in the Adjara Region of Georgia, and on patients with hypocortisolism in Italy. Both studies reported that social isolation during the pandemic caused significant psychological and/or physical distress on the observed individuals.  Data from the first study revealed that the impact of quarantine on people living with diabetes in the Adjara Region caused blood pressure (BP) levels to increase in 88.2% of patients with 50% of these cases resulting in high BP hospitalisation. In addition to these physical factors, increased feelings of anxiety and fear were observed on 82% of patients. In the second study, patients with hypocortisolism experienced increased anxiety and depression, associated with a dissatisfaction feeling of self and a reduced resiliency, when compared with Italian healthy controls. As these are all contributing factors to overall health deterioration, these findings suggest further research is required to allow patients with pre-existing conditions to remain fit and healthy during the current pandemic. In the Adjara Region study, Dr Liana Jashi and the research team disseminated an online questionnaire and collected answers from 16 endocrinologists and 22 family and general practice doctors. The study confirmed the negative, indirect effects social isolation and quarantine had on people living with diabetes. It reported a list of negative effects such as the reduced access to medical care, weight gain and increased cigarette and alcohol consumption. Physical activity decreased by 29.8%, a vital preventative to further physical and psychological problems.  "This study highlights that people living with diabetes require greater support during pandemics to maintain exercise and protect their physical and mental health. National health services should use these data and future studies to implement better social care around supporting people with pre-existing conditions," commented Dr Jashi. In the second study, Dr Chiara Simeoli at the University of Naples reported data collected during the last three weeks of the mass quarantine lasted 2 months in Italy, in a web-survey-based, multicenter, case- control research involving 12 different Italian centres. The study confirmed that a large cohort of 478 patients with hypocortisolism, and particularly, 363 with adrenal insufficiency and 115 with congenital adrenal hyperplasia, adequately treated with glucocorticoids, showed higher anxiety and depression, associated with a dissatisfaction feeling of self and a reduced resiliency, when compared with Italian healthy controls, suggesting the detrimental impact of social isolation on mental health of these patients, particularly frail and vulnerable to infections and stress. Moreover, patients with adrenal insufficiency reported a worse quality of life than patients with congenital adrenal hyperplasia.  "These findings confirmed that beyond the huge impact on physical health, COVID-19 epidemic, social isolation and mass quarantine represent significant psychological stressors, causing severe effects on mental health, even more on people with pre-existing conditions. An empowerment of psychological counselling for these vulnerable patients during COVID-19 should be considered by national health-care services," adds Dr Simeoli.  Both studies indicate that additional larger studies over a longer period of time are needed for further investigation.       Researchers discover link between local oxygen depletion in the brain and Alzheimer's disease University of Seville (Spain), May 24, 2021 The study, published in the journal Nature Aging and led by the laboratories of Dr. Alberto Pascual (CSIC), from the Neuronal Maintenance Mechanisms Group, and Prof. Javier Vitorica (University of Seville/CIBERNED) of the Physiopathology of Alzheimer's Disease Group at IBiS, demonstrates for the first time that low oxygen levels in the so-called senile plaques in the brain reduces the immune system's defensive capacity against the disease. The study also suggests that this lack of oxygen in the brain enhances the action of disorders associated with Alzheimer's disease that are characterized by low systemic oxygen levels, such as atherosclerosis and other cardiovascular diseases. What happens in the brain? A characteristic feature of Alzheimer's patients is the accumulation of highly toxic substances in their brains, known as senile plaques. The brain has an immune system whose main component are the microglial cells, which were first described and named 100 years ago by Pío del Río Hortega, a disciple of Ramón y Cajal. In the absence of damage, these cells facilitate the neurons' function. In response to Alzheimer's disease, microglia defend neurons by surrounding senile plaques, preventing their spread in the brain and decreasing damage. Alzheimer's disease is aggravated by other pathologies, such as cardiovascular diseases, which cause a decrease in oxygen levels in the body. This study has revealed reduced oxygen levels around senile plaques, compromising microglial activity (Image, center). When this is compounded by reduced oxygen supply to the brain due to other systemic pathologies, the microglia are unable to provide protection and there is an increase in the pathology associated with the disease. Relevance Alzheimer's disease is the leading cause of dementia in Spain and around the world. In Spain, its incidence is increasing dramatically as the population ages. Unfortunately, the origin of the disease remains unknown. The mechanism proposed in this study is mediated by the expression of the HIF1 molecule, whose discoverers received the Nobel Prize in Physiology or Medicine in 2019. Increased HIF1 levels compromise the mitochondrial activity of microglial cells and limit their protective capacity against disease. This study opens new lines of research to improve the metabolic capacity of microglia, which would enable a sustained response over time against the disease. Indirectly, the study supports previous work highlighting the importance of maintaining good cardiovascular health for healthy aging.   Effect of different doses of melatonin on learning and memory deficit in Alzheimer model Guilan University of Medical Sciences (Iran), May 21, 2021   According to news reporting out of Rasht, Iran, research stated, “Alzheimer Disease (AD) is an age-related neurodegenerative disorder with a progressive impairment of cognitive function. The pineal gland hormone melatonin (MEL) has been known as a protection agent against AD.” Our news reporters obtained a quote from the research from Guilan University of Medical Sciences: “However, the effect of melatonin in various doses is inconsistent. In this study, we aimed to investigate two doses of MEL on learning and memory in the amyloid-beta (Ab)-induced AD in the rats. Forty-eight male Wistar rats were used in the experiment and randomly divided control, sham, vehicle, AD, AD+MEL10 mg/kg, and AD+MEL 20 mg/kg groups. Intracerebroventricular injection of Ab1-42 was used to develop the animal model of AD. Also, MEL-treated groups received an intraperitoneal injection of MEL for 4 next weeks. The Morris Water Maze (MWM) and Passive Avoidance Learning (PAL) tests were used to examine animals’ learning and memory. The brain of animals was removed for immunohistochemistry for anti- Amyloid Precursor Protein (APP). Intra-peritoneal injection of MEL significantly improve learning and memory in MWM (P=0.000) and PAL test (P=0.000), but there were no significant changes in the two groups that received the melatonin (P>0.05). Histopathological analysis revealed that the clearance of APP deposition in the AD+MEL20 group was considerable compared with the AD+MEL10 group (P=0.000).” According to the news editors, the research concluded: “Our findings indicate that 10 and 20 mg/kg doses of melatonin have similar results on learning and memory in the AD model. But 20 mg/kg of melatonin has significantly more effect on the clearance of APP deposition.”     Effects of flaxseed on blood pressure, body mass index, and total cholesterol in hypertensive patients: A randomized clinical trial Lorestan University of Medical Sciences (Iran), May 25, 2021 Objectives Given the antioxidant properties of flaxseed and its biologically active ingredients, this study was conducted to determine the effects of flaxseed supplementation on body mass index (BMI), blood pressure, and total cholesterol levels in patients with hypertension. Methods In this triple-blind clinical trial, 112 patients, with an age range of 35 to 70 years, were randomized to 2 groups receiving 10 g (n=45) and 30 g (n=45) of flaxseed supplementation and 1 group receiving placebo (n=45) for 12 weeks by stratified block randomization. They were evaluated in terms of systolic (SBP) and diastolic blood pressure (DBP), BMI, and total serum cholesterol. Physical activity was measured using the International Physical Activity Questionnaire–Short Form (IPAQ–SF) and food intake was assessed using the Food Frequency Questionnaire (FFQ). The data were analyzed with SPSS, version 22, using the chi-square, Kruskal–Wallis, repeated measures analysis, ANOVA, and ANCOVA tests. Results The interaction effects among the study groups and time on the mean SBP (p = 0.001), DBP (p = 0.001), total cholesterol level (p = 0.032), and BMI (p < 0.001) were significant. During the study, the 30-g group achieved the best results, so that a 13.38-unit decrease in SBP was observed compared to a 1.72 unit increase in the placebo group and a 5.6-unit decrease in DBP was measured compared to a 2.39 unit increase in the placebo group. BMI decreased by 0.86 units compared to 0.06 units in the placebo group. Total cholesterol also decreased by 20.4 units compared to 11.86 units in the placebo group. Conclusion The results of this study showed that flaxseed can be effective in reducing blood pressure, total cholesterol, and body mass index in hypertensive patients in a twelve-week period.     Study: Don't count on caffeine to fight sleep deprivation Michigan State University, May 27, 2021 Rough night of sleep? Relying on caffeine to get you through the day isn't always the answer, says a new study from Michigan State University. Researchers from MSU's Sleep and Learning Lab, led by psychology associate professor Kimberly Fenn, assessed how effective caffeine was in counteracting the negative effects of sleep deprivation on cognition. As it turns out, caffeine can only get you so far. The study -- published in the most recent edition of Journal of Experimental Psychology: Learning, Memory, & Cognition -- assessed the impact of caffeine after a night of sleep deprivation. More than 275 participants were asked to complete a simple attention task as well as a more challenging "placekeeping" task that required completion of tasks in a specific order without skipping or repeating steps. Fenn's study is the first to investigate the effect of caffeine on placekeeping after a period of sleep deprivation. "We found that sleep deprivation impaired performance on both types of tasks and that having caffeine helped people successfully achieve the easier task. However, it had little effect on performance on the placekeeping task for most participants," Fenn said. She added: "Caffeine may improve the ability to stay awake and attend to a task, but it doesn't do much to prevent the sort of procedural errors that can cause things like medical mistakes and car accidents."  Insufficient sleep is pervasive in the United States, a problem that has intensified during the pandemic, Fenn said. Consistently lacking adequate sleep not only affects cognition and alters mood, but can eventually take a toll on immunity.  "Caffeine increases energy, reduces sleepiness and can even improve mood, but it absolutely does not replace a full night of sleep, Fenn said. "Although people may feel as if they can combat sleep deprivation with caffeine, their performance on higher-level tasks will likely still be impaired. This is one of the reasons why sleep deprivation can be so dangerous." Fenn said that the study has the potential to inform both theory and practice.  "If we had found that caffeine significantly reduced procedural errors under conditions of sleep deprivation, this would have broad implications for individuals who must perform high stakes procedures with insufficient sleep, like surgeons, pilots and police officers," Fenn said. "Instead, our findings underscore the importance of prioritizing sleep."     Parkinson's disease more likely in people with depression, study suggests Umea University (Sweden), May 21 2021     People with depression may be more likely to develop the movement disorder Parkinson's disease, according to new research published in Neurology.   According to the authors of the study, depression is more common in people with Parkinson's disease than those without the movement disorder. "We saw this link between depression and Parkinson's disease over a timespan of more than 2 decades, so depression may be a very early symptom of Parkinson's disease or a risk factor for the disease," says study co-author Prof. Peter Nordström, at Umeå University in Sweden. Parkinson's disease is a progressive disorder of the nervous system that affects how a person moves, including how they speak and write. As well as problems with movement, Parkinson's disease can also cause cognitive problems, neurobehavioral problems and sensory difficulties. The authors of the study state that depression is more common in patients with Parkinson's disease than in members of the general population. The mood disorder has a major influence on health-related quality of life and could also be involved in more rapid deterioration of cognitive and motor functions. However, few studies have investigated this association for periods of longer than 10 years, with any long-term findings so far inconclusive. For the study, the researchers used a cohort consisting of all Swedish citizens aged 50 years and above as of December 31st, 2005. From this group, they then took the 140,688 people diagnosed with depression . These individuals were each matched with three control participants (a total of 421,718 controls) of the same age and sex who had not been diagnosed with depression. The participants were then followed for up to 26 years. A total of 1,485 people with depression (1.1%) developed Parkinson's disease during this time, compared with 1,775 of those who did not have depression (0.4%). On average, Parkinson's disease was diagnosed 4.5 years after the beginning of the study, with the likelihood of the disorder developing decreasing over time. No sibling link found for depression and Parkinson's disease The researchers calculated that participants with depression were 3.2 times more likely than those without depression to develop Parkinson's disease within a year of the study beginning. After 15-25 years, the researchers found participants with depression were almost 50% more likely to develop the condition. If a participant's depression was severe, their likelihood of developing Parkinson's disease was also higher. For example, those who had been hospitalized for depression five or more times were 40% more likely to develop Parkinson's disease than participants who had been hospitalized for depression just once. In addition to these observations, the researchers examined siblings. No link was found between one sibling having Parkinson's disease and the other having depression. "This finding gives us more evidence that these two diseases are linked," says Prof. Nordström. "If the diseases were independent of each other but caused by the same genetic or early environmental factors, then we would expect to see the two diseases group together in siblings, but that didn't happen." The authors suggest there are a number of mechanisms that could explain their findings. Depression or antidepressive treatment could increase the risk of Parkinson's disease, depression could be an early symptom of Parkinson's disease, or that the two conditions could share environmental causative factors. In the paper, the authors acknowledge that they are unable to evaluate the potential role of substances used in antidepressive treatment as risk factors for Parkinson's disease. The study is an observational one and cannot determine causation. "Our findings suggest a direct association between depression and subsequent [Parkinson's disease], supported by a time-dependent hazard ratio, a dose-response pattern for recurrent depression, and a lack of evidence for coaggregation among siblings," the authors conclude. "Given that the association was significant over more than two decades of follow-up, depression may be a very early prodromal symptom of or a causal risk factor for [Parkinson's disease]." Elsewhere, a study published in December previously suggested that users of methamphetamine are at three times more risk of getting Parkinson's disease than people who do not use illegal drugs.

I went live on YouTube again for Talk Energy direct! This episode I tell the Ancova story in detail and talk about our different companies and how we got to where we are today. Click subscribe on YouTube or follow on the favorite podcast app! Website: https://talk.energy/​​​​​Spotify: https://lnkd.in/gZg_CHr​​​​​Twitter https://twitter.com/max_gagliardi​​​​

In this episode, Justin sits down with Max Gagliardi, Co-Founder of Ancova Energy and Host of the Talk Energy Podcast. Before we get going I want to highlight some fascinating technology provided by our sponsor, TechnipFMC. Their new and integrated iComplete™ ecosystem is digitally enabled and delivers efficiency benefits by dramatically reducing components and connections while simultaneously providing real time data to operators about the #wellpad operations. TechnipFMC is continuing to push the limits in order achieving full frac automation. To discover more about all the benefits of iComplete™ click the link in the shownotes or check them out on linkedin: https://lnkd.in/eeSVvcc Links: Max's LinkedIn: https://www.linkedin.com/in/maxgagliardi/  Talk Energy Podcast Website:  https://talk.energy Ancova Energy Website: https://www.ancova.com Talk Energy Apple Podcasts: https://podcasts.apple.com/us/podcast/talk-energy/id1542617540   Talk Energy Spotify: https://open.spotify.com/show/57ZDcZyEcpJqumNPMWtenV?si=dJyAyoHEQ6mVDm8f32ipEw&nd=1  Talk Energy Facebook: https://www.facebook.com/TalkEnergyPodcast TechnipFMC Giveaway https://lp.constantcontactpages.com/su/pcEvkKz/OGGN Ogio Dome duffle bag Yeti 20 oz purple tumbler Executive power bank Columbia neck gator AcePods 2.0 - True Wireless Stereo (TWS) Bluetooth Ear Buds Events HACK n WHACK: Anyone in the Houston area interested in playing oilfield hockey? Come join the Hack n Whack crew for some old timer hockey. We do it every two weeks at Memorial City Mall ice rink. Hit me up on LinkedIn for more details. Leave a Review Enjoy listening? Support the show by leaving a review in iTunes. Connect with OGGN Interested in Sponsoring? If you would like to get your company in front of our professional audience, please contact our Producer, Savannah Wilson. More Oil and Gas Global Network Podcasts Oil and Gas This Week Podcast | Oil and Gas HS&E Podcast | Oil and Gas Industry Leaders | Oil and Gas Legal Risk | Oil and Gas Onshore | Oil and Gas Offshore  | PITCH Podcast |Oil and Gas Tech Podcast | Women Offshore Podcast | Permian Perspective| Oil and Gas Elevate Podcast Engage with Oil and Gas Global Network LinkedIn Group | LinkedIn Company Page | Facebook | modalpoint | OGGN Street Team Facebook Group | LinkedIn Group Events on Deck: Get Modalpoint's Monthly Events Email Get Automatically Notified About Oil & Gas Events Once a Month Connect with Justin Gauthier LinkedIn | E-Mail | Oil and Gas Global Network

In this episode, Justin sits down with Max Gagliardi, Co-Founder of Ancova Energy and Host of the Talk Energy Podcast. Before we get going I want to highlight some fascinating technology provided by our sponsor, TechnipFMC. Their new and integrated iComplete™ ecosystem is digitally enabled and delivers efficiency benefits by dramatically reducing components and connections while simultaneously providing real time data to operators about the #wellpad operations. TechnipFMC is continuing to push the limits in order achieving full frac automation. To discover more about all the benefits of iComplete™ click the link in the shownotes or check them out on linkedin: https://lnkd.in/eeSVvcc Links: Max's LinkedIn: https://www.linkedin.com/in/maxgagliardi/  Talk Energy Podcast Website:  https://talk.energy Ancova Energy Website: https://www.ancova.com Talk Energy Apple Podcasts: https://podcasts.apple.com/us/podcast/talk-energy/id1542617540   Talk Energy Spotify: https://open.spotify.com/show/57ZDcZyEcpJqumNPMWtenV?si=dJyAyoHEQ6mVDm8f32ipEw&nd=1  Talk Energy Facebook: https://www.facebook.com/TalkEnergyPodcast TechnipFMC Giveaway https://lp.constantcontactpages.com/su/pcEvkKz/OGGN Ogio Dome duffle bag Yeti 20 oz purple tumbler Executive power bank Columbia neck gator AcePods 2.0 - True Wireless Stereo (TWS) Bluetooth Ear Buds Events HACK n WHACK: Anyone in the Houston area interested in playing oilfield hockey? Come join the Hack n Whack crew for some old timer hockey. We do it every two weeks at Memorial City Mall ice rink. Hit me up on LinkedIn for more details. Leave a Review Enjoy listening? Support the show by leaving a review in iTunes. Connect with OGGN Interested in Sponsoring? If you would like to get your company in front of our professional audience, please contact our Producer, Savannah Wilson. More Oil and Gas Global Network Podcasts Oil and Gas This Week Podcast | Oil and Gas HS&E Podcast | Oil and Gas Industry Leaders | Oil and Gas Legal Risk | Oil and Gas Onshore | Oil and Gas Offshore  | PITCH Podcast |Oil and Gas Tech Podcast | Women Offshore Podcast | Permian Perspective| Oil and Gas Elevate Podcast Engage with Oil and Gas Global Network LinkedIn Group | LinkedIn Company Page | Facebook | modalpoint | OGGN Street Team Facebook Group | LinkedIn Group Events on Deck: Get Modalpoint's Monthly Events Email Get Automatically Notified About Oil & Gas Events Once a Month Connect with Justin Gauthier LinkedIn | E-Mail | Oil and Gas Global Network

Greg and Patrick discuss issues of controlling for extraneous variables, by randomization and by design, but especially the challenges and assumptions associated with statistical control. Along the way they also mention drag racing, Volkswagen Bugs, Seabiscuit, Harrison Bergeron, Diet Coke, Janet Jackson, John Denver, gastrointestinal distress, Sewall Wright, and babies and bathwater.

Dietary intake of adult vegetarians from large prospective studies has been well-characterized but is rarely reported in vegetarian adolescents. Our objective was to describe and compare the dietary intake of vegetarian adolescents with their non-vegetarian counterparts in a population known to espouse healthy living. Adolescents (n = 534) aged 12–18 years old from middle and high schools near major Adventist universities in Michigan and Southern California provided dietary, demographic, and anthropometric data. Dietary intake was measured with a validated 151-item self-administered web-based food frequency questionnaire; weight and height were measured during school visits. Vegetarian was defined as the combined intake of meat, meat derivatives, poultry, and fish of

4-factor, 5-factor, 6-factor designs (between subjects), interactions, follow-up tests, intro to ANCOVA

Across all disciplines, the ability to test theories by experimentation is vital for validation and discovery. When designing an experiment, the researcher hopes to maximize the obtained information by reducing wasted resources and allocating treatments in such a way as to minimize variances. Ideally, a design will account for major sources of variation so that the researcher can be confident the effects of treatments are not confounded with extraneous factors. In this course, the basic principles of experimental design will be given and specific designs discussed. The first designs introduced will be completely randomized designs, the most straightforward design when a researcher wants to test for differences among multiple treatments. Optimal blocking strategies will then be presented as a variance-reducing technique, e.g. perhaps the researcher feels a subject's gender may significantly affect observations. For each design we will discuss implementation, appropriate analysis and provide examples in SAS. If time permits we may also introduce more complicated designs tailored specifically to the researchers attending the course. This 2 hour course is broken up into 18 parts. 1 - Introduction 2 - Obs Study vs Designed Experiment 3 - Design Example 4 - Design Fundamentals 5 - Lady Tasting Tea Example (Assignment) 6 - Intro to completely Randomized Design 7 - Analysis - Linear Model 8 - CRD Linear Model; ANOVA; and Estimability 9 - CRD Analysis Example in JMP 10 - Factorial Treatment; Linear Model; ANOVA 11 - Factorial Analysis Example in JMP 12 - Exercises 13 - ANCOVA; Linear Model 14 - ANCOVA Example in JMP 15 - Blocking 16 - Randomized Complete Block Design 17 - RCBD Analysis Example in JMP 18 - Blocking vs ANCOVA Course files available here: www.lisa.stat.vt.edu/?q=node/4687.

Across all disciplines, the ability to test theories by experimentation is vital for validation and discovery. When designing an experiment, the researcher hopes to maximize the obtained information by reducing wasted resources and allocating treatments in such a way as to minimize variances. Ideally, a design will account for major sources of variation so that the researcher can be confident the effects of treatments are not confounded with extraneous factors. In this course, the basic principles of experimental design will be given and specific designs discussed. The first designs introduced will be completely randomized designs, the most straightforward design when a researcher wants to test for differences among multiple treatments. Optimal blocking strategies will then be presented as a variance-reducing technique, e.g. perhaps the researcher feels a subject's gender may significantly affect observations. For each design we will discuss implementation, appropriate analysis and provide examples in SAS. If time permits we may also introduce more complicated designs tailored specifically to the researchers attending the course. This 2 hour course is broken up into 18 parts. 1 - Introduction 2 - Obs Study vs Designed Experiment 3 - Design Example 4 - Design Fundamentals 5 - Lady Tasting Tea Example (Assignment) 6 - Intro to completely Randomized Design 7 - Analysis - Linear Model 8 - CRD Linear Model; ANOVA; and Estimability 9 - CRD Analysis Example in JMP 10 - Factorial Treatment; Linear Model; ANOVA 11 - Factorial Analysis Example in JMP 12 - Exercises 13 - ANCOVA; Linear Model 14 - ANCOVA Example in JMP 15 - Blocking 16 - Randomized Complete Block Design 17 - RCBD Analysis Example in JMP 18 - Blocking vs ANCOVA Course files available here: www.lisa.stat.vt.edu/?q=node/4687.

Across all disciplines, the ability to test theories by experimentation is vital for validation and discovery. When designing an experiment, the researcher hopes to maximize the obtained information by reducing wasted resources and allocating treatments in such a way as to minimize variances. Ideally, a design will account for major sources of variation so that the researcher can be confident the effects of treatments are not confounded with extraneous factors. In this course, the basic principles of experimental design will be given and specific designs discussed. The first designs introduced will be completely randomized designs, the most straightforward design when a researcher wants to test for differences among multiple treatments. Optimal blocking strategies will then be presented as a variance-reducing technique, e.g. perhaps the researcher feels a subject's gender may significantly affect observations. For each design we will discuss implementation, appropriate analysis and provide examples in SAS. If time permits we may also introduce more complicated designs tailored specifically to the researchers attending the course. This 2 hour course is broken up into 18 parts. 1 - Introduction 2 - Obs Study vs Designed Experiment 3 - Design Example 4 - Design Fundamentals 5 - Lady Tasting Tea Example (Assignment) 6 - Intro to completely Randomized Design 7 - Analysis - Linear Model 8 - CRD Linear Model; ANOVA; and Estimability 9 - CRD Analysis Example in JMP 10 - Factorial Treatment; Linear Model; ANOVA 11 - Factorial Analysis Example in JMP 12 - Exercises 13 - ANCOVA; Linear Model 14 - ANCOVA Example in JMP 15 - Blocking 16 - Randomized Complete Block Design 17 - RCBD Analysis Example in JMP 18 - Blocking vs ANCOVA Course files available here: www.lisa.stat.vt.edu/?q=node/4687.

Background: Breathlessness is a common and distressing symptom affecting many patients with advanced disease both from malignant and non-malignant origin. A combination of pharmacological and non-pharmacological measures is necessary to treat this symptom successfully. Breathlessness services in various compositions aim to provide comprehensive care for patients and their carers by a multiprofessional team but their effectiveness and cost-effectiveness have not yet been proven. The Breathlessness Support Service (BSS) is a newly created multiprofessional and interdisciplinary outpatient service at a large university hospital in South East London. The aim of this study is to develop and evaluate the effectiveness and cost effectiveness of this multidisciplinary out-patient BSS for the palliation of breathlessness, in advanced malignant and non-malignant disease. Methods: The BSS was modelled based on the results of qualitative and quantitative studies, and systematic literature reviews. A randomised controlled fast track trial (RCT) comprising two groups: 1) intervention (immediate access to BSS in addition to standard care); 2) control group (standard best practice and access to BSS after a waiting time of six weeks). Patients are included if suffering from breathlessness on exertion or at rest due to advanced disease such as cancer, chronic obstructive pulmonary disease (COPD), chronic heart failure (CHF), interstitial lung disease (ILD) or motor neurone disease (MND) that is refractory to maximal optimised medical management. Both quantitative and qualitative outcomes are assessed in face to-face interviews at baseline, after 6 and 12 weeks. The primary outcome is patients' improvement of mastery of breathlessness after six weeks assessed on the Chronic Respiratory Disease Questionnaire (CRQ). Secondary outcomes for patients include breathlessness severity, symptom burden, palliative care needs, service use, and respiratory measures (spirometry). For analyses, the primary outcome, mastery of breathlessness after six weeks, will be analysed using ANCOVA. Selection of covariates will depend on baseline differences between the groups. Analyses of secondary outcomes will include patients' symptom burden other than breathlessness, physiological measures (lung function, six minute walk distance), and caregiver burden. Discussion: Breathlessness services aim to meet the needs of patients suffering from this complex and burdensome symptom and their carers. The newly created BSS is different to other current services as it is run in close collaboration of palliative medicine and respiratory medicine to optimise medical care of patients. It also involves professionals from various medical, nursing, physiotherapy, occupational therapy and social work background.

Analyse of Covariance. Wat voor output verschijnt bij correctie in SPSS?

Analyse of Covariance. Wat voor output verschijnt bij correctie in SPSS?

Like most other organisms, human behaviour is under control of a circadian (= about a day) clock which can adapt to the daily change of light and darkness. The capability of the circadian clock to synchronize to the light-dark cycle is highly systematic and under genetic control. Daily behaviour of humans can vary greatly, leading to different chronotypes and extreme chronotypes are commonly described as 'owls and larks'. While larks fall asleep in the early evening and wake up early in the morning, owls go to bed when larks wake up, sleeping until about noon. Recently, the Munich ChronoType Questionnaire (MCTQ) has been developed in order to quantitatively assess chronotype and to face problems arising from common work day schedules. Chronotypes are normally distributed in the general population. MSF-Sc, the middle of sleep phase on free days corrected for sleep dept accumulated on work days, is used as reference point for chronotype. The objectives of this study were both to validate and improve the MCTQ and to identify and estimate biological and social factors that potentially influence the distribution of chronotypes. Test-retest reliability was controlled at an interval of six months (n=101). Both dates show a highly significant correlation (p0.027, Bonferoni corrected level of significance: p=0.0012). Test-retest reliability was controlled separately for females and males, different age (≤30 years and >30 years), and chronotype groups (MSF-Sc ≤4.28 and >4.28). A sample of 15 people was tested at an interval of three weeks. The results of both dates correlate with high significance (p0.05, Bonferoni corrected level of significance: p=0.002). The capability of the MCTQ to assess actual sleep times was tested with 6-week long sleep logs (n=628). Again, gender, age, and chronotype groups were evaluated separately and chronotypes were separated into five different groups (MSF-Sc

Objective: Irritability is often linked with problem drinking. The aim of this study is to examine the possible influence of irritability on craving induced by a cue-exposure paradigm. Methods: 30 male abstinent alcoholic inpatients of the Psychiatric Hospital of Munich University, Germany gave answers to a series of personality questionnaires. Results of this study concerning the impact of aggressivity on craving for alcohol has recently been published. In this study, the subjects were subdivided into a low- and a high-irritable group based on their scores on the irritability subscale of the Buss-Durkee Hostility Inventory and were exposed to alcohol cues. Craving was measured by means of the Alcohol Craving Questionnaire (ACQ) and Visual Analogue Scales (VAS). The heart rate was also assessed throughout the whole process. ANCOVA for repeated measurement was employed to evaluate the data - irritability disposition as the between-subject factor and the experimental manipulation (absence vs. presence of alcohol cues) as the within-subject factor. Results: Major findings are: (1) main effects of irritability on `emotionality', `purposefulness', and `expectancy' of the ACQ as well as on `craving for alcohol' of the VAS were significant; (2) cue exposure also exerted a significant main effect on I craving for alcohol' of the VAS and on the heart rate after the presentation of alcohol cues; (3) on `compulsivity' of the ACQ and `intention to alcohol intake' of the VAS; there was a significant interaction between irritability and cue exposure. The high-irritable alcoholics, compared with their statements in the baseline, tended to report a higher control over alcohol intake and a lower intention to alcohol use after cue exposure. However, after confrontation with alcohol stimuli, their low-irritable counterparts reported a much lower control and a slightly higher intention than they did in the baseline. Conclusions: The results of this study indicate that induced craving in hospitalized alcohol addicts probably varies with the magnitude of their irritability; it might make patients more aware of their vulnerability to alcohol, help them develop more differential coping strategies and improve medical therapy against alcohol craving. Copyright (C) 2002 S. Karger AG, Basel.