Podcasts about dbp

In this episode, we highlight vitamin D₃ in gastrointestinal health, with a focus on intestinal barrier function and the gut-immune axis. We discuss how vitamin D is metabolized into its active form, 1,25-dihydroxyvitamin D, and how 1,25-dihydroxyvitamin D can support the intestinal mucosa, while highlighting the intestinal epithelium and immune cells in the lamina propria. Through this, we further detail the role of regulatory T cells in supporting immune balance and modulating immune function.Topics:1. Introduction - Highlighting intestinal barrier function and the gut-immune axis with a focus on vitamin D₃ 2. Vitamin D Synthesis and Metabolism - Skin and 7-dehydrocholesterol; dietary intake.- Transported through the bloodstream bound to vitamin D binding protein.- First hydroxylation in the liver to form 25-hydroxyvitamin D₃ (25(OH)D₃).- Testing.- Second hydroxylation in the kidney to form the active 1,25 dihydroxyvitamin D₃ (1,25(OH)₂D₃).- Local activation also occurs. 3. Intestinal Barrier Anatomy - The intestinal epithelium forms a selectively permeable monolayer that interfaces with the gut lumen.- Covered by a mucus layer: mucins, antimicrobial peptides, secretory IgA.- Mucus layer provides physical and biochemical protection.- Tight junction proteins and paracellular permeability.- Molecules crossing the epithelium. - Disruption of tight junctions, immune cell exposure to luminal contents.- The lamina propria and Gut-Associated Lymphoid Tissue (GALT). - Maintaining tolerance while defending against pathogens.  4. Vitamin D's Role in Barrier Support and Immune Modulation - 1,25-dihydroxyvitamin D₃, tight junction integrity, immune regulation, and more.- Regulatory T Cells (Tregs) and immune balance.   5. Vitamin D₂ and D₃- D₃ (cholecalciferol) is more biologically effective and binds DBP more strongly.  6. Vitamin D Levels - Levels observed in autoimmune conditions, IBS, and more.- Symptoms.- Insufficient and excessive levels of vitamin D can be detrimental.- Multi-system.  7. Conclusion - Multifactorial: Numerous factors regulate vitamin D levels.- Gastrointestinal health root cause approach.Thanks for tuning in!Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Follow Chloe on TikTok @chloe_c_porterVisit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more!

This week on DBP, it's Part 1 for the Purple 1! That's bc the first half of our long awaited, hotly anticipate 2000s Prince Tournament has finally arrived, just in time for April Aggravation! Your Presenters and their AI counter-presenter, ChatDBP, draft 16 songs exclusively from Prince's 2000s catalogue and have them face off against each other in a series of crazy ass match-ups, ONE MINUTE AT A (morrisdayandthe) TIME! Let's explore this lesser known but still sonically rich period of the Artist Formerly Known as the Artist Formerly Known as Prince's career and have some laughs & fun while doing so! 

N Engl J Med 1986; 314:1547-52Background Into the mid-1980's, digoxin and diuretics were the mainstay of chronic disease management for congestive heart failure. Vasodilator agents were also commonly used based on limited data of their favorable hemodynamic effects. No sufficiently powered trials in this space had been performed to assess whether administration of vasodilators or any other agents improved long-term morbidity or mortality for heart failure patients. The V-HEFT trial was undertaken to test the hypotheses that 2 widely used vasodilator regimens (prazosin or a combination of hydralazine and isosorbide dinitrate) were superior for reducing death versus placebo. The trial was sponsored by the Veterans Administration and only enrolled men.Patients Men between the ages of 18 and 75 were recruited from 11 participating Veterans Administration hospitals and had to have chronic congestive heart failure based on either evidence of cardiac dilatation or left ventricular dysfunction (EF 0.7 ng/mL and euvolemic volume status. Clinical evaluations and exercise-tolerance tests on 2 consecutive visits, two weeks apart, had to reveal clinical and exercise stability before randomization could occur. Following randomization, patients continued to receive the optimal dose of digoxin and diuretic along with 1 of 3 study regimens. The placebo group was given placebo tablets and placebo capsules and instructed to take them 4 times a day. The prazosin group took 2.5 mg prazosin capsules and placebo tablets 4 times a day. The hydralazine-isosorbide dinitrate group took 37.5 mg hydralazine capsules and 20 mg isosorbide dinitrate tablets 4 times a day.In all groups, therapy began with 1 capsule and 1 tablet to be taken 4 times a day. In the absence of side effects, this was increased to 2 capsules and 2 tablets 4 times a day for a total of 20 mg of prazosin or 300-160 mg of hydralazine-isosorbide dinitrate. If drug-related side effects occurred, the dose could be reduced to half a tablet 4 times per day or to one capsule 2 times per day. If the dose was reduced, an attempt was made later to reinstitute the full dose.In order to limit dropouts, rigorous criteria were established for “treatment failures.” Physicians were advised to hospitalize patients with worsening symptoms, and, if appropriate, to use temporary intravenous vasodilator or inotropic interventions for stabilization. Physicians were encouraged to resume study medications upon discharge. At least 2 such hospitalizations were required, along with objective evidence of deterioration, before the study medications were discontinued and replaced with known therapy.Endpoints The primary endpoint was all-cause mortality.Results 642 patients were enrolled (273 in placebo group, 183 in prazosin group and 186 in the hydralazine-isosorbide dinitrate group). Excluding discontinuations that took place within 1 month before death, 47 patients (17%) discontinued one or both types of placebos, 43 patients (23%) discontinued prazosin, and 60 patients (32%) discontinued either one or both drugs in the hydralazine-isosorbide group. Six months after randomization, the average prescribed doses were 18.6 mg per day of prazosin, 270 mg per day of hydralazine, and 136 mg per day of isosorbide dinitrate. More than 85% of the prescribed drugs were taken in each treatment group.The mean follow-up was 2.3 years (range 6 months to 5.7 years). Only 4 patients were lost to follow up (2 in placebo group, 1 in prazosin group, and 1 in hydralazine-dinitrate group). There were 120 deaths in placebo group (44%; 19 per 100 patient years), 91 in the prazosin group (50%; 22 per 100 patient years), 72 in the hydralazine-dinitrate group (39%; 17 per 100 patient years). A reduction in mortality over the entire follow-up period was observed in the hydralazine-nitrate group compared with placebo (p = 0.093 on the log-rank test and p = 0.046 on the generalized Wilcoxon test, which gives more weight to treatment differences occurring in the earlier part of the mortality curves and less weight to the latter part, where the numbers are smaller). The absolute difference in mortality between these groups increased during three years and then began to diminish. The absolute difference in mortality between the placebo group and hydralazine-isosorbide groups at years 1 through 4 was 7%, 9%, 11% and 4%, respectively.Prespecified subgroup analysis in CAD vs no CAD stratification showed no significant treatment effect heterogeneity for hydralazine-nitrate among those with CAD although the absolute difference in mortality between groups was numerically higher for patients with CAD.At 8 weeks and 1 year, SBP (-4.1 and -4.6 mmHg) and DBP (-3.2 and -2.7 mmHg) decreased the most in the prazosin group compared to placebo. Hydralazine-nitrate was not associated with a statistically significant nor clinically significant difference in BP with exception of DBP at 8 weeks. The EF rose significantly at 8 weeks and 1 year in the hydralazine-nitrate group (+2.9 and +4.2) compared to placebo but not in the prazosin group.Side effects were reported in 4.0% of placebo patients, 11% of prazosin patients and 19% of hydralazine-nitrate patients, respectively. The most common side effects were headache and dizziness. Headache was reported in 12% of hydralazine-nitrate patients.Conclusions This study compared the combination of hydralazine-isosorbide dinitrate or prazosin to placebo in patients with chronic congestive heart failure who were optimized on digoxin and diuretic therapy. In what appears to be a young (58 years) and highly selected population of clinically stable, male veterans with dilated cardiomyopathies and low symptom burdens, the combination of hydralazine-isosorbide reduced death by 2 per 100 patient years, increased EF by 4% at 1 year and did not significantly alter BP compared to placebo. Side effects were reported in approximately 1 out of 5 patients with the most common being headache and approximately 1 out of 3 discontinued 1 or both study drugs. Prasozin did not reduce death or increase EF but did reduce BP compared to placebo. The internal validity of the study is high with only a few minor imbalances in baseline characteristics, which do not appear clinically relevant nor to consistently favor any one group. Less than 1% of patients were lost to follow up with no significant imbalances between groups. The external validity is limited by the fact that this is a population of male veterans and the etiologic distribution of cardiomyopathy and heart failure is likely different from a general heart failure population; etiologic causes of death are also likely to be different. Furthermore, the population is highly selected and its unclear how many patients from the general heart failure population would meet study criteria.Cardiology Trial's Substack is a reader-supported publication. To receive new posts and support our work, consider becoming a free or paid subscriber. Get full access to Cardiology Trial's Substack at cardiologytrials.substack.com/subscribe

It's time for WEE Nation Reads with UMBC, starting our 2nd year of partnership with the Diverse Books Project. Today's interview is with Author Monica Brown, author of "Marisol McDonald Doesn't Match/ Marisol McDonald no combina" Website: leeandlowbooks.com and Facebook @MonicaBrownAuthor. This segment is sponsored by UMBC's Sherman Center for Early Learning in Urban Communities, which serves as a resource to participating teachers and families in their Diverse Books Projects (DBP).  This project aims to ensure that early childhood educators at their partner schools have access to high-quality, diverse children's books and opportunities to share ideas and insights about their use. Books identified by UMBC will be featured in our WEE Nation Reads with UMBC segment, which includes a reading of each of the selected books, children's music related to each book, and an interview with the author or publisher. Go to WEE Nation Radio for more information, or download our mobile app on Android and iPhones by searching "WEE Nation Radio" in your App Store. www.WEENationRadio.com.

Tucker and Eduardo break down Drake's thrilling come-from-behind semifinal victory over the Belmont Bruins with a live report from DBP field correspondent Dolph Pulliam.

Tucker and Eduardo break down the Bulldogs' 70-53 victory over the Southern Illinois Salukis in the Arch Madness Quarterfinals with a little help from DBP sidelines reporter Dolph Pulliam.

The Sincerity Series is back with a vengeance and Your Fabulous Fellows of DBP take this opportunity to recount their favourite musical* discoveries of the year that just was: 2024! They're meaningfully mentioning their most highly regarded discoveries of new, discoveries of olde and rediscoveries of the annum. Plus maybe a little return to fan favourite game, Stumpy V. Dumpy??  *And yes when we say musical, we are of course talking about Dear Evan Hansen!

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Trenna Sutcliffe is a developmental behavioral pediatrician and the founder and medical director of the Sutcliffe Clinic in the San Francisco Bay Area, where she partners with families to provide care for children facing behavioral challenges, developmental differences, and school struggles. In this episode, Trenna shares her journey into developmental and behavioral pediatrics, including her pioneering work at Stanford and her expertise in autism, ADHD, and anxiety—the "three As." She explores the diagnostic processes, the overlap and comorbidities of these conditions, and the importance of personalized treatment plans that address both medical and environmental factors. Trenna offers valuable insights into the changing prevalence of autism, the impact of evolving diagnostic criteria, and the range of therapies and medications available to support children and their families. She also discusses the challenges in accessing care and the critical need for a holistic approach that bridges healthcare and education. We discuss: Trenna's passion for developmental-behavioral pediatrics (DBP), and the process of diagnosing anxiety, ADHD, and autism [3:15]; Understanding anxiety and ADHD: assessing impairment and self-esteem and identifying anxiety and emotional well-being in young patients [9:45]; The evolving diagnosis of autism: understanding the spectrum and individual needs [16:30]; The dramatic rise in autism spectrum disorder (ASD): genetics, environment, expanded diagnostic criteria, and more [25:45]; Exploring epigenetics and the potential multigenerational impact of environment exposures on susceptibility to certain disorders [37:15]; The evolution of autism classifications, and the particular challenges for children with level 1 (mild) autism due to a lack of support [41:15]; The broadening of the autism spectrum: benefits and risks of expanded diagnostic criteria and the need for future frameworks to focus on better outcomes [48:00]; The overlap between ASD, ADHD, and anxiety [57:15]; Understanding oppositional defiant disorder, and the importance of understanding the “why” behind a behavior when creating treatment plans [1:00:45]; Defining developmental-behavioral pediatrics (DBP), and Trenna's professional journey [1:07:00]; Updated methods of ABA (applied behavioral analysis) therapy: evolution, controversies, challenges of scaling autism care, and the need for tailored interventions [1:13:45]; Advice for parents trying to find and evaluate care for children with autism, ADHD, or anxiety [1:22:45]; Tailored treatments for ADHD: balancing stimulant medications with behavioral training [1:28:30]; The interplay between medication, behavioral therapy, and neuroplasticity in managing ADHD, and the potential to grow out of the need for medication [1:39:45]; Using medication to treat anxiety and other symptoms in kids with autism without ADHD [1:44:45]; FAQs about medicating children with ADHD: benefits, side effects, dosage, and more [1:46:30]; The “superpowers” associated with level 1 autism [1:48:45]; The next steps to increase support for children with ASD, anxiety, and ADHD [1:50:45]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

BUSINES: LandBank, DBP on 'solid financial footing' – Finance chief | Jan. 3, 2025Visit our website at https://www.manilatimes.netFollow us:Facebook - https://tmt.ph/facebookInstagram - https://tmt.ph/instagramTwitter - https://tmt.ph/twitterDailyMotion - https://tmt.ph/dailymotionSubscribe to our Digital Edition - https://tmt.ph/digitalSign up to our newsletters: https://tmt.ph/newslettersCheck out our Podcasts:Spotify - https://tmt.ph/spotifyApple Podcasts - https://tmt.ph/applepodcastsAmazon Music - https://tmt.ph/amazonmusicDeezer: https://tmt.ph/deezerStitcher: https://tmt.ph/stitcherTune In: https://tmt.ph/tunein#TheManilaTimes Hosted on Acast. See acast.com/privacy for more information.

DirtyBitPodcast 328- Midnight Confessions This New Years tale is not just tread by SeXXXySherry  but she is the author as well. On New Year's Eve in a bustling city, two strangers meet  at an exclusive rooftop party. A mix of romance and  desire leads them into a night they'll never forget.

It's time for WEE Nation Reads with UMBC, starting our 2nd year of partnership with the Diverse Books Project. Today's interview is with Author Melissa Iwai, author of "Soup Day." Website: https://www.melissaiwai.com and IG @melissaiwai1. This segment is sponsored by UMBC's Sherman Center for Early Learning in Urban Communities, which serves as a resource to participating teachers and families in their Diverse Books Projects (DBP).  This project aims to ensure that early childhood educators at their partner schools have access to high-quality, diverse children's books and opportunities to share ideas and insights about their use. Books identified by UMBC will be featured in our WEE Nation Reads with UMBC segment, which includes a reading of each of the selected books, children's music related to each book, and an interview with the author or publisher. Go to WEE Nation Radio for more information, or download our mobile app on Android and iPhones by searching "WEE Nation Radio" in your App Store. www.WEENationRadio.com.

DirtyBitPodcast 326- Last Night On Earth This is from Christian Pan book THE BLUE HOUR,  his 14th book and read by SeXXXySherry. Story:  LAST NIGHT ON EARTH - a woman discovers that  bondage can lead to freedom, and that submission  can lead to power. Christian Pan www.christianpanerotica.com x (twitter) @Christian_Pan_

Send us a textNo episódio inaugural de dezembro, as apresentadoras Mariana e Marôla trazem um olhar aprofundado sobre os mais recentes avanços científicos relacionados ao pulmão do prematuro. Diferente dos Journal Clubs anteriores, este episódio é inteiramente dedicado às estratégias de prevenção e tratamento da desafiadora displasia broncopulmonar (DBP), um dos maiores desafios na neonatologia.Mariana inicia com uma análise detalhada do aguardado PLUSS Trial, que investigou os efeitos do uso combinado de budesonida e surfactante no manejo da DBP. Este estudo tem gerado grande expectativa pela possibilidade de redefinir o cuidado respiratório em prematuros.1. Intratracheal Budesonide Mixed With Surfactant for Extremely Preterm InfantsThe PLUSS Randomized Clinical Trialhttps://jamanetwork.com/journals/jama/article-abstract/2826118?utm_campaign=articlePDF&utm_medium=articlePDFlink&utm_source=articlePDF&utm_content=jama.2024.17380Na sequência, Marôla apresenta dois artigos complementares sobre o uso de recrutamento pulmonar antes da administração de surfactante. O primeiro destaca os achados originais do estudo IN-REC-SUR-E, enquanto o segundo explora os desfechos clínicos aos dois anos de idade, oferecendo uma visão longitudinal sobre o impacto dessa técnica.2. Lung recruitment before surfactant administration in extremely preterm neonates with respiratory distress syndrome (IN-REC-SUR-E): a randomized, unblinded, controlled trialhttps://pubmed.ncbi.nlm.nih.gov/32687801/3. Lung Recruitment Before Surfactant Administration in Extremely Preterm Neonates: 2-Year Follow-Up of a Randomized Clinical Trialhttps://pubmed.ncbi.nlm.nih.gov/39320892/Para encerrar o episódio, Mariana discute os achados de um estudo robusto que avaliou a relação entre o uso de corticosteroides sistêmicos no tratamento da DBP e a sobrevida livre de paralisia cerebral, trazendo reflexões importantes para a prática clínica.4. Systemic Postnatal Corticosteroids, Bronchopulmonary Dysplasia,and Survival Free of Cerebral Palsyhttps://jamanetwork.com/journals/jamapediatrics/article-abstract/2826219?utm_campaign=articlePDF&utm_medium=articlePDFlink&utm_source=articlePDF&utm_content=jamapediatrics.2024.4575Este episódio especial, inteiramente dedicado ao pulmão do prematuro, marca com excelência o início do último mês do ano. Esperamos que você aproveite as discussões e se inspire com os avanços apresentados!Nos vemos no próximo episódio! Não esqueça: você pode ter acesso aos artigos do nosso Journal Club no nosso site: https://www.the-incubator.org/podcast-1 Lembrando que o Podcast está no Instagram, @incubadora.podcast, onde a gente posta as figuras e tabelas de alguns artigos. Se estiver gostando do nosso Podcast, por favor dedique um pouquinho do seu tempo para deixar sua avaliação no seu aplicativo favorito e compartilhe com seus colegas. Isso é importante para a gente poder continuar produzindo os episódios. O nosso objetivo é democratizar a informação. Se quiser entrar em contato, nos mandar sugestões, comentários, críticas e elogios, manda um e-mail pra gente: incubadora@the-incubator.org

Dirtybitpodcast 323- Evil In The Ass A naughty Halloween tale by JA Martin and read by SeXXXySherry. A man buys himself a sex toy. While he plays with it, he discovers  that it is haunted. Now, with his girlfriend, a new buddy, and two priests, he must figure out what to do with the demonic sex toy. follow JA Martin X (twitter) @JaMartin1973 http://www.amazon.com/stores/JA%20Martin/author/B07XPB4D5H

We're back!!! After what feels like a lifetime, we are finally back drinking and dishing out all things DBP. Not only do we break the silence on where we have been hiding for all these months, but Sarah also shares with us her most recent trip to Napa and Sonoma where she tasted some delicious… Continue reading Ep141: The Bitches are Back

Join U.S. Army Iraq Combat Medic Veteran and host of America's Heroes Group, Dr. Damon Arnold, as he sits down with fellow veteran and public health expert Kenneth Campbell, DBP, MPH, MBA, MA. In this episode, they discuss the critical role of veterans in public health and emergency preparedness, the importance of A.I. and infrastructure in addressing health inequities, and the mission of ADAPHP, LLC. Kenneth Campbell, a former executive assistant to the director of the Illinois Department of Public Health and a Marine Corps veteran, shares his experiences in managing large-scale public health crises, including the COVID-19 pandemic. The discussion also covers how veterans can play a key role in the evolving landscape of technology, public health, and emergency management.Watch now to learn about the vital intersections of health, technology, and infrastructure, and how veterans can continue to serve their communities beyond the battlefield.

Nếu có một nước nào phải theo dõi sát sao và với đầy nỗi lo lắng một trục Nga – Trung ngày càng được củng cố, thì đó chính là Nhật Bản. Bị giới hạn về địa lý và chịu sức ép từ gánh nặng lịch sử, Nhật Bản có nguy cơ đối mặt cùng lúc với hai đối thủ cường quốc hạt nhân, thậm chí có thể là ba, nếu bao gồm cả mối đe dọa Bắc Triều Tiên trong vùng Đông Á. Nỗi lo này đã được thể hiện rõ trong Sách Trắng quốc phòng thường niên « Quốc phòng Nhật Bản 2024 », được công bố ngày 12/07/2024, cho rằng Nhật Bản « đang phải đối mặt với một môi trường an ninh nghiêm trọng và phức tạp nhất kể từ khi kết thúc Đệ Nhị Thế Chiến ».Lần đầu tiên Tokyo cảnh báo trực tiếp về « khả năng một tình huống nghiêm trọng tương tự như cuộc xâm lược Ukraina của Nga xảy ra ở khu vực Ấn Độ - Thái Bình Dương trong tương lai, đặc biệt là ở vùng Đông Á », ám chỉ đến những hoạt động quân sự của Trung Quốc xung quanh đảo Đài Loan.Đài Loan và mối lo an ninh cho Nhật BảnTheo nhận định của Yoshinaga Kenji, cựu sĩ quan tình báo của Cơ quan Điều tra An ninh và Lực lượng Phòng vệ Biển Nhật Bản, với trang The Diplomat, « phần đầu của Sách Trắng quốc phòng năm nay, mô tả tình hình an ninh xung quanh Nhật Bản, là phần căng thẳng nhất trong lịch sử Sách Trắng, khi xét đến cuộc chiến xâm lược kéo dài của Nga tại Ukraina, áp lực quân sự ngày càng lớn của Trung Quốc đối với Đài Loan và việc Bắc Triều Tiên triển khai vũ khí hạt nhân chiến thuật ».Lập trường đối ngoại cứng rắn cùng với đà trỗi dậy mạnh mẽ năng lực quân sự của Bắc Kinh đặt Tokyo trước một thách thức chiến lược lớn chưa từng có. Bộ trưởng Quốc Phòng Nhật Bản Kihara Minoru mở đầu Sách Trắng với đánh giá « không quốc gia nào có thể tự bảo vệ an ninh của mình ». Ông nhấn mạnh đến sự cần thiết tăng cường hợp tác với các quốc gia có cùng chí hướng mà Tokyo chia sẻ các giá trị phổ quát và lợi ích chiến lược.Nhật Bản bày tỏ « quan ngại nghiêm trọng » về các hoạt động quân sự của Trung Quốc trên toàn khu vực xung quanh Nhật Bản, từ biển Hoa Đông – đặc biệt xung quanh quần đảo Senkaku đang tranh chấp chủ quyền với Trung Quốc – cho đến biển Nhật Bản, Tây Thái Bình Dương, nhất là xung quanh Đài Loan, trước nguy cơ « xảy ra căng thẳng quân sự giữa Trung Quốc và Đài Loan, do những hoạt động quân sự ngày càng tăng từ phía Bắc Kinh ».Về điểm này, nhà nghiên cứu địa chính trị Valérie Niquet, chuyên gia về Trung Quốc thuộc Quỹ Nghiên cứu Chiến lược FRS, trong một chương trình tranh luận trên đài phát thanh France Culture (18/05/2024), đưa ra một số phân tích :« Đài Loan có một vị thế quan trọng cả về mặt ý thức hệ, cho thấy một mô hình dân chủ vẫn có thể tồn tại trong thế giới Trung Hoa, điều mà Tập Cận Bình hoàn toàn phủ nhận, và cả về mặt chiến lược, vì Đài Loan là chốt chặn lối ra Thái Bình Dương và do vậy không thể để cho Đài Loan rơi vào tay Bắc Kinh. Đó là chưa nói đến người dân.Câu hỏi lớn được đặt ra ở đây là mối quan hệ chiến lược quốc phòng giữa Nhật Bản với Hoa Kỳ. Các căn cứ chính của Mỹ ở châu Á đều nằm ở Nhật Bản và chủ yếu ở quần đảo Okinawa, nằm ở tuyến đầu đối diện với Đài Loan, (với 53.000 lính Mỹ).Hòn đảo cuối cùng, Yonaguni, nằm gần nhất với đảo cực tây của Nhật Bản, chỉ cách bờ biển Đài Loan khoảng 100 km, nên thực sự Nhật Bản ở trên tuyến đầu. Hơn nữa, khi Trung Quốc tập trận để gây áp lực với Đài Loan, vào lúc bà Nancy Pelosi thăm Đài Loan cách đây không lâu, 5 hay 6 quả tên lửa, tôi quên mất con số chính xác, đã rơi vào vùng đặc quyền kinh tế ở Biển Nhật Bản. Đây rõ ràng còn là lời cảnh báo đối với Nhật Bản, gây áp lực buộc nước này không được đi quá xa. »Nga - Trung hợp tác quân sự : « Cơn ác mộng » cho Nhật BảnNhưng điều làm Tokyo đặc biệt lo lắng là khả năng Bắc Kinh và Matxcơva siết chặt hơn nữa quan hệ hợp tác quân sự. Tokyo xem những cuộc tập ném bom chung và tuần tra hải quân chung thường xuyên giữa hai cường quốc này là « nhằm mục đích phô trương sức mạnh chống Nhật Bản ».Đây không phải là lần đầu tiên Nhật Bản cho thấy nỗi bất an về quan hệ hợp tác Nga - Trung. Trang South China Morning Post ngày 27/11/2023 trích dẫn một báo cáo an ninh của Viện Nghiên cứu Quốc Phòng (NIDS), một tổ chức tư vấn trực thuộc bộ Quốc Phòng Nhật Bản, cho thấy một trong những nỗi lo sợ lớn nhất của Tokyo là hai cường quốc này thực sự trở thành đồng minh quân sự.Dưới thời thủ tướng Shinzo Abe (2012-2020), Nhật Bản đã nỗ lực thiết lập một chính sách đối ngoại hòa dịu với Nga. Cố thủ tướng Abe đã có gần 30 cuộc gặp với tổng thống Vladimir Putin nhằm gầy dựng một mối quan hệ tin cậy, một mặt là để giải quyết các tranh chấp chủ quyền trên quần đảo Kuril, dưới sự kiểm soát của Nga từ năm 1945.Vùng « Lãnh thổ phương bắc » này, theo cách gọi của Nhật Bản, có một vị trí chiến lược, nằm ở phía bắc đảo Hokkaido và là chốt chặn cửa biển Okhotsk. Nhưng nỗ lực này của ông Abe chẳng mang lại kết quả : Nga không những không nhượng một tấc đất lãnh thổ nào mà còn tăng cường sự hiện diện quân sự trên quần đảo, bố trí 3500 binh lính và nhất là lắp đặt các hệ thống tên lửa địa đối không S-300 vào cuối năm 2020.Mặt khác, theo phân tích của nhà địa chính trị học Céline Pajon, Viện Quan hệ Quốc tế Pháp (IFRI) trên báo Libération ngày 25/03/2022, ông Abe còn nhắm đến mục tiêu chiến lược xa hơn. Khi tìm cách xích lại gần Putin, thủ tướng Nhật Bản hy vọng tránh để Nga rơi vào quỹ đạo Trung Quốc, hay chí ít là ngăn chặn việc hình thành một mặt trận Nga - Trung chống Nhật Bản trong các vấn đề lãnh thổ và lịch sử.Một lần nữa ông Abe lại gặp thất bại. Matxcơva lệ thuộc ngày càng nhiều vào Bắc Kinh về kinh tế và hai bên có những cam kết hợp tác quân sự chưa từng có. Quân đội Nga và Trung Quốc tiến hành nhiều cuộc tập trận quy mô lớn tại vùng Viễn Đông, tổ chức các cuộc tuần tra chung xung quanh Nhật Bản, khiến Tokyo phải lo lắng.Trước nguy cơ phải đối mặt với cùng lúc hai cường quốc hạt nhân Nga – Trung trong các vấn đề tranh chấp lãnh thổ, và thậm chí có thể có bên thứ ba là Bắc Triều Tiên, tháng 12/2022, chính phủ của thủ tướng Fumio Kishida công bố ba tài liệu chiến lược quan trọng : Chiến lược An ninh Quốc gia (NSS), Chiến lược Phòng thủ Quốc gia (NDS) và Chương trình Tăng cường Phòng thủ (DBP).Theo nhiều nhà quan sát tại Pháp, cuộc chiến xâm lược Ukraina do Nga phát động đã có những tác động đáng kể đến việc vạch ra chiến lược an ninh cho Nhật Bản. Tài liệu NSS đánh giá Trung Quốc như là một « thách thức chiến lược chưa từng có » và xem Bắc Triều Tiên là một « mối đe dọa nghiêm trọng hơn và sắp xảy ra ». Nhưng, nước Nga, không giống như trong phiên bản NSS năm 2013, cùng sự phối hợp chiến lược của Matxcơva với Bắc Kinh, giờ được xác định là « mối quan tâm sâu sắc về an ninh ».AUKUS: Giải pháp để thoát gọng kềm Nga – Trung ?Nhật Bản còn thông báo tăng đáng kể ngân sách quốc phòng với mục tiêu từ đây đến năm 2027 đạt mức chi tiêu quân sự 2% GDP như các nước thành viên Liên minh Quân sự Bắc Đại Tây Dương NATO. Đáng chú ý là lần đầu tiên Nhật Bản cho biết tham vọng sở hữu năng lực phản công, để nước này thực hiện các cuộc tấn công trả đũa nhằm vào lãnh thổ đối thủ.Giáo sư Tsuyoshi Goroku, ngành Quan hệ Quốc tế và Kinh tế, trường đại học Nishogakusha, trong cuộc trả lời phỏng vấn dành riêng cho Quỹ Nghiên cứu Chiến lược (FRS) của Pháp hồi tháng 3/2024, lưu ý bước tiến lịch sử này, « không phải là một sự đảo ngược đột ngột các nguyên tắc chính sách quốc phòng truyền thống của đất nước. Đúng hơn đó là một sự thừa nhận của Tokyo về môi trường an ninh ngày càng xấu đi của Nhật Bản. Điều này là kết quả của một loạt những thay đổi tăng dần trong suốt hai thập niên qua. Tuy nhiên, việc Nga vô cớ xâm lược Ukraina là một lời cảnh báo cho Nhật Bản, củng cố những đánh giá ảm đạm và thúc đẩy hơn nữa những thay đổi này ».Vị giáo sư Nhật Bản thừa nhận đất nước ông đã hưởng được một nền an ninh và sự thịnh vượng trong khuôn khổ trật tự quốc tế dựa trên các luật lệ. Nhưng việc Nga và Trung Quốc có tham vọng thay đổi trật tự đó khiến Nhật Bản cảm thấy bất an. Trong suốt hai năm qua, thủ tướng Fumio Kishida nhiều lần cảnh báo « Ukraina hôm nay rất có thể sẽ là Đông Á ngày mai » và « an ninh của châu Âu và vùng Ấn Độ - Thái Bình Dương là không thể tách rời ».Và cảm giác bất an này dường như được đông đảo công luận Nhật Bản chia sẻ. Giáo sư Tsuyoshi Goroku giải thích :« Sau cuộc xâm lược của Nga, một số cuộc thăm dò dư luận cho thấy công chúng Nhật Bản ngày càng lo sợ an ninh của Nhật Bản đang bị đe dọa. Ngoài ra, một cuộc khảo sát do tờ Nikkei thực hiện vào tháng 3 năm 2022 cho thấy 77% số người được hỏi "lo ngại" nếu cộng đồng quốc tế không ngăn chặn được cuộc xâm lược của Nga và việc thay đổi biên giới, điều này sẽ dẫn đến việc Trung Quốc sử dụng vũ lực chống Đài Loan. Liệu cuộc xâm lược của Nga và thành công có thể của cuộc chiến này có khuyến khích Trung Quốc sử dụng vũ lực hay không, đó vẫn còn là vấn đề tranh luận, nhưng công chúng Nhật Bản đã thể hiện rõ những lo ngại này. »Trong hai ngày 16 - 17/05/2024, tổng thống Nga Vladimir Putin đã đến thăm Bắc Kinh gặp chủ tịch Trung Quốc Tập Cận Bình, cuộc gặp lần thứ 43 kể từ khi ông Tập Cận Bình lên cầm quyền năm 2012. Trong chuyến thăm này, tổng thống Nga đã đến thăm Harbin, nơi có Viện Công nghệ Quân sự Trung Quốc. Một chuyến thăm mang tính biểu tượng cao, một tín hiệu mạnh mẽ gởi đến Nhật Bản và các nước phương Tây : Nga và Trung Quốc đang thắt chặt quan hệ hợp tác, kể cả về công nghiệp vũ khí.Trong bối cảnh này, Nhật Bản quan ngại về các hoạt động quân sự của Nga và sự phối hợp chiến lược của Nga với Trung Quốc trong vùng Ấn Độ - Thái Bình Dương. Chiến tranh Ukraina kéo dài, Bắc Triều Tiên có thể sẽ can dự với việc cung cấp tên lửa và đạn dược cho Nga. Mối quan hệ hợp tác quân sự Matxcơva – Bình Nhưỡng càng làm cho môi trường an ninh Nhật Bản thêm phần u ám.Đối diện với những mối đe dọa an ninh chưa từng có này, thủ tướng Fumio Kishida đã gia tăng các hoạt động ngoại giao, thiết lập các mối quan hệ chiến lược với nhiều nước từ châu Á đến châu Âu, từ việc mở rộng quan hệ đối tác với NATO, cho đến việc để ngỏ khả năng tham gia liên minh quân sự AUKUS, hiện quy tụ ba nước Anh, Mỹ và Úc. Về điểm này, nhà địa chính trị học Valerie Niquet nhận định :« Ưu điểm lớn của AUKUS so với các đối tác khác: đây là một liên minh Anglo-Saxon và do vậy sẽ không làm Washington tức giận, vì Úc và Anh là những đồng minh rất thân thiết của Mỹ và Nhật Bản đã ký kết những thỏa thuận hợp tác trao đổi, chẳng hạn như tạo điều kiện thuận lợi cho các cuộc tập trận chung với cả Úc và Anh.Hơn nữa, chúng ta không thể quên một thực tế là việc tham gia một phần vào liên minh AUKUS, không liên quan đến khía cạnh hạt nhân, mà có lẽ là trụ cột đầu tiên như người ta nói về hợp tác công nghệ đối với Nhật Bản, cũng có yếu tố uy tín theo nghĩa Nhật Bản trở lại với trường quốc tế với tư cách là một tác nhân chính, cả trong lĩnh vực công nghiệp quân sự, điều vẫn chưa có trên phương diện xuất khẩu vũ khí ».

Friends, Family, Mortal Enemies - the critically acclaimed and hotly anticipated Season 6 of DBP reconvenes! Baby, we're back and we're boreder than ever! Your Hiatus-Completed Presenters break down every single Number One single on the Billboard Hot 100 during the personally pivotal year that was 2007. We're talkin' & rankin' Singular Songs by the likes of Beyonce, Kanye, Justin Timbersnake ermm Timberlake, Akon, Sean Kingston, Fergie and even a few more! Did we love all the tracks discussed? Most possibly not! But that's ok, bc It's the Bored Bills 2007!

For the first time ever, DBP is going live! We are so excited to announce the details of our very own wine tasting in collaboration with our favorite local wine shop, Ray's Wine & Spirits. Their one and only Wine & Spirits Director, Nate Norfolk, joins us to pop a special bottle and celebrate our… Continue reading Announcing the FIRST DBP event

DBP is back after a year hiatus reacting to Heat vs Celtics game 1, Ryan Garcia vs Devin Haney scores and what's next, and the NFL Draft and the Colts.

Nesse episódio do Journal Club, apresentamos quatro artigos sobre assuntos bem diversos, de publicações recém-saídas do forno.1. "Hydrocortisone in very preterm neonates for BPD prevention: meta-analysis and effect size modifiers" ou Hidrocortisona em neonatos muito prematuros para prevenção da DBP: metanálise e efeito modificadores de tamanho Afinal, a hidrocortisona precoce pode prevenir DBP em prematuros? Disponível em: https://pubmed.ncbi.nlm.nih.gov/38237961/2. "Factors influencing C-reactive protein status on admission in neonates after birth" ou Fatores que influenciam o estado de proteína C-reativa na admissão em neonatos após o nascimento Importante para saber quais os fatores que influenciam o valor da proteína C-reativa (PCR) em neonatos na admissão após o nascimento.Disponível em: https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-024-04583-83. "Peri-extubation settings in preterm neonates: a systematic review and meta-analysis" ou Parâmetros de peri-extubação em recém-nascidos prematuros: uma Revisão sistemática e meta-análiseEsse artigo revisou 1) os parâmetros peri-extubação; e 2) associação entre ajustes peri-extubação e desfechos em recém-nascidos prematuros.Disponível em: https://www.nature.com/articles/s41372-024-01870-14. "Transition to Adulthood for Extremely Preterm Survivors"  ou Transição para a vida adulta para sobreviventes prematuros extremos Afinal, os jovens adultos que foram prematuros extremos apresentam mais dificuldades em diversos aspectos de suas vidas?Disponível em: https://publications.aap.org/pediatrics/article-abstract/153/1/e2022060119/196245/Transition-to-Adulthood-for-Extremely-Preterm?redirectedFrom=fulltextE fique ligado nos próximos episódios especiais de A Incubadora: a gente vai trazer para vocês um pouco do que rolou no NeoBrain Brasil 2024!  Não esqueça: você pode ter acesso aos artigos do nosso Journal Club no nosso site: https://www.the-incubator.org/podcast-1 Se estiver gostando do nosso Podcast, por favor deixe sua avaliação no seu aplicativo favorito e compartilhe com seus colegas. O nosso objetivo é democratizar a informação. Se quiser entrar em contato, nos mandar sugestões, comentários, críticas e elogios, manda um e-mail pra gente: incubadora@the-incubator.org

Wie es das Leben der Menschen beeinflusst, wenn sie nicht gut lesen können, was das für ihr Arbeitsleben oder ihre politische Teilnahme bedeutet, das berichtet Journalistin Jenny Witt. Mit Bildungsforschenden, einer Neurowissenschaftlerin und Pädagoginnen hat sie Ursachen der Krise diskutiert und sich durch zahlreiche Studien gelesen. In einer Grundschule hat sie das erfolgversprechende Modell des "Lesebands" erlebt. Und was kann ein Lesehund bewirken? Host Maja Bahtijarevic führt durch die Recherche und die wissenschaftliche Ursachensuche - ein ganzes Ursachenbündel liegt der Lesekrise zugrunde, das die beiden Journalistinnen gründlich und tiefgehend aufdröseln. Sie schauen auch in die Synapsen unseres Gehirns - und zeigen auf, wie wichtig Vorlesen ist, nicht nur für zukünftige Lesefähigkeit, sondern auch für das Eltern-Kind-Verhältnis. HINTERGRUNDINFORMATIONEN Internationale Grundschul-Lese-Untersuchung 2021 (IGLU): https://doi.org/10.31244/9783830997009 IQB-Bildungstrend 2022: https://doi.org/10.31244/9783830997771 LEO-Studie 2018: https://doi.org/10.3278/6004740w Internationale Schulleistungsstudie PISA 2022: https://doi.org/10.3278/6004956w Jugend, Information und Medien-Studie (JIM-Studie) 2022: https://www.mpfs.de/studien/jim-studie/2022/ Bericht zur Studie über die Wirksamkeit verbindlicher "Lesebänder": https://doi.org/10.46586/SLLD.189 Vorlesemonitor 2023 der Stiftung Lesen, der Deutsche Bahn-Stiftung und der Zeit: https://www.stiftunglesen.de/fileadmin/PDFs/PM/2023/Vorlesemonitor2023_final.pdf Studie: Frühes Vorlesen und der Umgang zwischen Eltern und Kindern (2019): https://doi.org/10.1097/DBP.0000000000000687 Studie: Auswirkungen des Vorlesens auf Mutter-Kind-Beziehungen (2020): https://doi.org/10.1037/dev0000940 Metastudie zu den Auswirkungen elektronischer Bücher auf die frühen Lesekenntnisse junger Kinder (2021): https://doi.org/10.3390/ijerph18126510 Mehr Hintergrund zu dieser Folge: www.ndr.de/nachrichten/info/podcastsynapsen368.html Mehr über Wissenschaft bei NDR Info: ndr.de/wissen 100 Mal Synapsen - was war eure Lieblingsfolge? Wir haben noch eine Bitte an euch - zu einem besonderen Anlass: Die Synapsen nähern sich der 100. Folge (können wir selbst kaum glauben)! Hundert Mal haben wir euch schon Wissenschaft und aktuelle Forschung in aller Tiefe und Ausgewogenheit nahegebracht zu Themen wie Rassismus in der Medizin und Tiefsee-Bergbau, zu Fragen wie: Warum führen Menschen Krieg? Oder: Haben Tiere Gefühle? Jetzt wollen wir etwas von euch wissen: Was war eure Lieblingsfolge? Welches Thema fandet ihr besonders spannend? Und: Womit sollen wir uns in Zukunft unbedingt einmal befassen? Außerdem würden wir sehr gern hören, was ihr an den Synapsen besonders schätzt. Schreibt uns oder schickt uns eine Sprachnachricht an: synapsen@ndr.de

Wie es das Leben der Menschen beeinflusst, wenn sie nicht gut lesen können, was das für ihr Arbeitsleben oder ihre politische Teilnahme bedeutet, das berichtet Journalistin Jenny Witt. Mit Bildungsforschenden, einer Neurowissenschaftlerin und Pädagoginnen hat sie Ursachen der Krise diskutiert und sich durch zahlreiche Studien gelesen. In einer Grundschule hat sie das erfolgversprechende Modell des "Lesebands" erlebt. Und was kann ein Lesehund bewirken? Host Maja Bahtijarevic führt durch die Recherche und die wissenschaftliche Ursachensuche - ein ganzes Ursachenbündel liegt der Lesekrise zugrunde, das die beiden Journalistinnen gründlich und tiefgehend aufdröseln. Sie schauen auch in die Synapsen unseres Gehirns - und zeigen auf, wie wichtig Vorlesen ist, nicht nur für zukünftige Lesefähigkeit, sondern auch für das Eltern-Kind-Verhältnis. HINTERGRUNDINFORMATIONEN Internationale Grundschul-Lese-Untersuchung 2021 (IGLU): https://doi.org/10.31244/9783830997009 IQB-Bildungstrend 2022: https://doi.org/10.31244/9783830997771 LEO-Studie 2018: https://doi.org/10.3278/6004740w Internationale Schulleistungsstudie PISA 2022: https://doi.org/10.3278/6004956w Jugend, Information und Medien-Studie (JIM-Studie) 2022: https://www.mpfs.de/studien/jim-studie/2022/ Bericht zur Studie über die Wirksamkeit verbindlicher "Lesebänder": https://doi.org/10.46586/SLLD.189 Vorlesemonitor 2023 der Stiftung Lesen, der Deutsche Bahn-Stiftung und der Zeit: https://www.stiftunglesen.de/fileadmin/PDFs/PM/2023/Vorlesemonitor2023_final.pdf Studie: Frühes Vorlesen und der Umgang zwischen Eltern und Kindern (2019): https://doi.org/10.1097/DBP.0000000000000687 Studie: Auswirkungen des Vorlesens auf Mutter-Kind-Beziehungen (2020): https://doi.org/10.1037/dev0000940 Metastudie zu den Auswirkungen elektronischer Bücher auf die frühen Lesekenntnisse junger Kinder (2021): https://doi.org/10.3390/ijerph18126510 Mehr Hintergrund zu dieser Folge: www.ndr.de/nachrichten/info/podcastsynapsen368.html Mehr über Wissenschaft bei NDR Info: ndr.de/wissen 100 Mal Synapsen - was war eure Lieblingsfolge? Wir haben noch eine Bitte an euch - zu einem besonderen Anlass: Die Synapsen nähern sich der 100. Folge (können wir selbst kaum glauben)! Hundert Mal haben wir euch schon Wissenschaft und aktuelle Forschung in aller Tiefe und Ausgewogenheit nahegebracht zu Themen wie Rassismus in der Medizin und Tiefsee-Bergbau, zu Fragen wie: Warum führen Menschen Krieg? Oder: Haben Tiere Gefühle? Jetzt wollen wir etwas von euch wissen: Was war eure Lieblingsfolge? Welches Thema fandet ihr besonders spannend? Und: Womit sollen wir uns in Zukunft unbedingt einmal befassen? Außerdem würden wir sehr gern hören, was ihr an den Synapsen besonders schätzt. Schreibt uns oder schickt uns eine Sprachnachricht an: synapsen@ndr.de

Even later but with still with a lot of love (hehe), here are your Presenters 3 of DBP's top TV Shows and Movies from 2023! With a special IN PERSON record for the Movie portion! 

Made a little late but with a lot of love (hehe), here are your Presenters 3 of DBP's top tier upper decker long player discs from this past annum! From old ass artistes to young & hip outfits, you'll never believe who made the cut this time around... or will you!

In Episode 137  Ben talks with Dr. Kat Monlux, a behavior analyst and Associate Professor at Oslo Metropolitan University whose primary areas of study include infants at risk of developmental disorders and behavior-analytic interventions for individuals with Fragile X Syndrome.  In this episode, Ben and Kat dive deep into her research in both areas.    Continuing Education Units (CEUs): https://cbiconsultants.com/shop BACB: 1.5 Learning  IBAO: 1.5 Learning QABA: 1.5 General Links: Loukia Tsami https://www.linkedin.com/in/loukia-tsami-bcba-42538159/ Hayley Neimy https://www.linkedin.com/in/hayley-neimy-phd-bcbad/   Articles Referenced Neimy, H., Pelaez, M., Carrow, J., Monlux, K., & Tarbox, J. (2017). Infants at risk of autism and developmental disorders: Establishing early social skills.Behavioral Development Bulletin, 22(1), 6–22. https://doi.org/10.1037/bdb0000046 Monlux, K.D., Pollard, J.S., Bujanda Rodriguez, A.Y. et al. Telehealth Delivery of Function-Based Behavioral Treatment for Problem Behaviors Exhibited by Boys with Fragile X Syndrome. J Autism Dev Disord 49, 2461–2475 (2019). https://doi.org/10.1007/s10803-019-03963-9 Neimy, H., Pelaez, M., Monlux, K. et al. Increasing Vocalizations and Echoics in Infants at Risk of Autism Spectrum Disorder. Behav Analysis Practice 13, 467–472 (2020). https://doi.org/10.1007/s40617-020-00413-2 Katerina Monlux, Martha Pelaez & Per Holth (2019) Joint attention and social referencing in children with autism: a behavior-analytic approach, European Journal of Behavior Analysis, 20:2, 186-203, DOI: 10.1080/15021149.2019.1644831   Hall, S.S., Monlux, K.D., Rodriguez, A.B. et al. Telehealth-enabled behavioral treatment for problem behaviors in boys with fragile X syndrome: a randomized controlled trial. J Neurodevelop Disord 12, 31 (2020). https://doi.org/10.1186/s11689-020-09331-4 Pelaez, M., Monlux, K. Development of Communication in Infants: Implications for Stimulus Relations Research. Perspect Behav Sci 41, 175–188 (2018). https://doi.org/10.1007/s40614-018-0151-z Martha Pelaez & Katerina Monlux (2017) Operant conditioning methodologies to investigate infant learning, European Journal of Behavior Analysis, 18:2, 212-241, DOI: 10.1080/15021149.2017.1412633   Monlux, Katerina D. MS*; Pollard, Joy S. PhD*,†; Bujanda Rodriguez, Arlette Y. MA*,†; Hall, Scott S. PhD*. Conducting In-Home Functional Analyses of Aggression and Self-Injury Exhibited by Boys with Fragile X Syndrome. Journal of Developmental & Behavioral Pediatrics 43(4):p e237-e245, May 2022. | DOI: 10.1097/DBP.0000000000001019 Vismara, L. A., McCormick, C. E. B., Wagner, A. L., Monlux, K., Nadhan, A., & Young, G. S. (2018). Telehealth Parent Training in the Early Start Denver Model: Results From a Randomized Controlled Study. Focus on Autism and Other Developmental Disabilities, 33(2), 67-79. https://doi.org/10.1177/1088357616651064 COPY CITATION    

Lancet 1990;336:65-71.Background Large trials up to this point had established the role of thrombolytic therapy and aspirin in patients with acute MI. The next question centered on the different types of thrombolytic agents as well as the merits of adding high dose heparin to aspirin following revascularization. Data from smaller studies showed that alteplase (tPA) had a higher recanalization rate at 90 minutes compared to streptokinase (SK). “Recanalization” is a surrogate endpoint – a person doesn't necessarily care whether their artery is open or not at 90 minutes, but instead, whether they live or die, and how they live in the aftermath of a heart attack. The GISSI-2 trial sought to test the hypothesis that tPA would reduce the composite hard endpoint of mortality and extensive LV dysfunction compared to streptokinase (SK) and that heparin plus aspirin compared to aspirin alone would do the same.Cardiology Trial's Substack is a reader-supported publication. To receive new posts and support our work, consider becoming a free or paid subscriber.Patients Patients were eligible who presented with chest pain and ST segment elevations of ≥1 mm in any limb lead of the ECG and/or ≥2 mm in any precordial leads and were admitted to the CCU within 6 hr from the onset of symptoms. Absolute contraindications included: recent or current bleeding, stroke within the previous 6 months, a surgical or invasive procedure or trauma within the previous 2 weeks, uncontrolled hypertension defined as SBP ≥200 mmHg or DBP ≥110 mmHg, or previous treatment with SK within 6 months.Baseline characteristics The number of patients who were admitted to CCUs with acute myocardial infarctions (MI) over the study period was 38,086 and 12,490 (33%) were ultimately enrolled. Reasons for exclusion included: more than 6 hr from onset of symptoms (61%), contraindications to fibrinolysis (15%), unlikely to have acute MI (13%), administrative reasons (5%), ST depressions (4%) and 1% were not reported. Similar to GISSI-1, which also provided information on patients enrolled versus those who were not, women were more likely to be excluded (30% of excluded vs 20% of enrolled) as were patients >70 years of age (41% of excluded vs 22% of enrolled). The death rate of those excluded was higher (11% of excluded vs 9% of enrolled).Approximately 80% of patients enrolled were men under the age of 70. Patients with inferior (34%) and anterior STEMI's (31%) composed more than half of the cohort. 72% of patients presented within 3 hours of symptom onset and over 95% had Killip scores of II or below with the vast majority being Killip I (78%).Procedures Immediately following randomization half of all patients received either 1.5 MU of SK infused over 1 hour or 100 mg of tPA infused over 3 hours. Since this was a 2x2 factorial design, half of all patients also received 12,500 U of subcutaneous heparin twice daily starting 12 hours after the beginning of the tPA or SK infusion and to be continued until hospital discharge.All patients without specific contraindications were recommended to receive oral aspirin 325 mg/day and 5-10 mg of IV atenolol, even before randomization, as soon as evolving MI was diagnosed.Endpoints The combined primary endpoint consisted of all-cause mortality plus the number of patients who had late (day 4 or later) clinical congestive heart failure, or extensive LV damage (LVEF

Lancet 1986;397-401Background This study by the Italian Group for the Study of Streptokinase in Myocardial Infarction (GISSI) is the first large trial to test the hypothesis that opening blocked heart arteries, in this case via use of the intravenous thrombolytic agent Streptokinase, reduces death in patients presenting with acute myocardial infarction (MI). Opening blocked arteries or revascularization is now a foundational element of cardiovascular medicine that arguably spurred much of the growth in the field over the 1990's and early 2000's. Therefore, it is critical to revisit this historic trial and appreciate the lessons it taught us.Patients Patients were eligible who presented with chest pain and ST segment elevations of ≥1 mm in any limb lead of the electrocardiogram and/or ≥2 mm in any precordial leads and were admitted to the cardiac intensive care unit (CCU) within 12 hours from the onset of symptoms. Absolute contraindications included recent or current bleeding, stroke within the previous 2 months, a surgical procedure or trauma within the previous 10 days, invasive procedures within the previous 10 days, SBP ≥200 mmHg, DBP ≥110 mmHg, previous treatment with streptokinase, or any other life-threatening condition.Baseline characteristics The number of patients who were admitted to CCUs with acute MIs over the study period was 31,826 and 11,806 (37%) were ultimately enrolled. Reasons for exclusion included being more than 12 hr from onset of symptoms (51%), contraindications to Streptokinase (21%), unlikely to have acute MI (19%), administrative reasons (8%) and 2% were not reported. Notably, women were more likely to be excluded (27% of excluded vs 20% of enrolled) as were patients >75 years of age (21% of excluded vs 11% of enrolled).Not a lot of demographic information is provided on the cohort in the main manuscript but it was composed primarily of men (80%) who were ≤65 years of age (65%). Only a small percentage of patients were unstable, as evidenced by SBP ≤90 mmHg (

Last day of the 2023, many highs many lows. This first week of 2024 we welcome Jamal & Raymon to start the new year and it's always a pleasure conversing with these two gentlemen. 2023 vices: Gambling, Candy, Pre Workout...Organic relationships in terms of matchmaking, social media dating and AI wives.Them IG stories spread throughout the week with no interest in coming back to the gym. Lifters vs hoopers and LA fitness memories. The most anticipated Toronto trip story with the gang, ending with a chipped tooth. Lost but never forgotten

JEFFERY RUTLEDGE IS BACK!!! One of the newest additions to the wonderfully terrifying DBP militia. This week we talk about our experiences with our babies not people babies but the equipment that is essential to the work and never ending grind in both content creation, realty, and trucking. Audio/video podcasting, the future of Beloveds & affiliates. The island we live on as creators. The pitfalls and failures in creativity and the disconnect in relation to others. End of the world scenario where do you wanna be located in theses United States? The ends and outs of OTR trucking and the sacrifices that need explanations. The grand finale of this conversation is the comparison between ownership in logistics and ownership in real-estate. MOVIE REVIEW (OPPENHEIMER, NAPOLEAN, KILLERS OF THE FLOWER MOON) Song: Stories About My Brother- DrakeGuest:https://www.instagram.com/realtorrutledge/jeff@michiganrealty.orgSupport the showsolo.to/hatch

Join Sarah as she meets two awesome physicians from the Division of Developmental & Behavioral Pediatrics (DDBP) at CCHMC! Dr. Cassandra Conrad and Dr. Sara Williams are super neat docs who use their passions to integrate care for their complex patients. DBP is a growing field that achieves an impressive intersection of specialty and primary care in medicine--stay tuned for all their great advice and stories!Please contact either physician for elective rotation info, shadowing, questions, or comments!Dr. Conrad at cassandra.conrad@cchmc.orgDr. Williams at sara.williams3@cchmc.org

The following question refers to Section 4.7 of the 2021 ESC CV Prevention Guidelines. The question is asked by student Dr. Shivani Reddy, answered first by NP Carol Patrick, and then by expert faculty Dr. Eileen Handberg.Dr. Handberg is an Adult Nurse Practitioner, Professor of Medicine, and Director of the Cardiovascular Clinical Trials Program in the Division of Cardiovascular Medicine at the University of Florida. She has served as Chair of the Cardiovascular Team Section and the Board of Trustees with the ACC and is the President Elect for the PCNA.The CardioNerds Decipher The Guidelines Series for the 2021 ESC CV Prevention Guidelines represents a collaboration with the ACC Prevention of CVD Section, the National Lipid Association, and Preventive Cardiovascular Nurses Association.Enjoy this Circulation 2022 Paths to Discovery article to learn about the CardioNerds story, mission, and values. Question #34 Ms. BW presents after her best friend was diagnosed with hypertension and is interested in measuring her own blood pressure. According to the ESC Guidelines, what BP screening approach is recommended for making a diagnosis of hypertension? ARepeated measurements in one visitBA single measurement in a single visitCRepeated measurements in more than one visit  DReported patient history  Answer #34 Explanation The correct answer is C – Repeated measurements in more than one visit.It is recommended to base the diagnosis of hypertension on repeated office BP measurements on more than one visit except when hypertension is severe (e.g., Grade 3—defined as SBP > 180 and/ or DBP >110mmHg—and especially in high-risk patients) (Class I, LOE C). In addition to recommending repeat measurements across visits, the guidelines provide a number of considerations for appropriately measuring blood pressure, such as taking measurements when seated in a quiet environment for 5 minutes and measuring in both arms at the first visit and using the higher-level value arm for visits thereafter (see Table 14 on page 3283).Additionally, home blood pressure monitoring is recommended as an alternative to repeated office measurements. Blood pressure measurements are taken with a semiautomated, validated cuff for 3 consecutive days – and 6-7 days being preferred – in the morning and at night, averaged over that period. Notably, home blood pressure thresholds for the diagnosis of hypertension are lower than for that of in-office measurements, with a daytime systolic of 135mmHg or diastolic of 85mmHg given as the level at which hypertension is diagnosed, as opposed to 140mmHg and 90mmHg for systolic and diastolic levels, respectively, given for in-office diagnosis.Main TakeawayWith the exception of those with severely elevated blood pressures, the diagnosis of hypertension requires repeated measurements across multiple office visits.Guideline Loc.Sections 4.7.1 and 4.7.2, Table 13 and 14, Figure 14 CardioNerds Decipher the Guidelines - 2021 ESC Prevention SeriesCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor RollCardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron!

Okay so maybe not a week later like originally promised, but here we finally are with part 2 of the highly helpful Hurricane Katrina Charity song Tournament courtesy of DBP and many great artists! 8 more songs and 3 more rounds left, but who will wind up victorious? Listen to this epi to find out, of course!

Sixteen musical compositions - all allegedly created to benefit the victims of the infamously devastating Hurricane Katrina of 2005 - duke it out in this unforgettable song tournament presented by Your Presenters 3 of DBP! Tracks by international legends of the World like Celine Dion, U2, Stevie Wonder, Prince, Motley Crue, Jimmy Buffet (rip) and JoJo

Alcohol Intake and Blood Pressure Levels: A Dose-Response Meta-Analysis of Nonexperimental Cohort Studies 

Phthalates =Childhood Leukemia and Autism  Marijuana from $35 – $80 PER OUNCE   How to Spot Phthalates on Ingredients Lists  Unfortunately, ingredient lists generally make it difficult to identify phthalates. They are usually written as a 3 or 4-word acronym. Here are some to look out for:  BBP (butyl benzyl phthalate)  DBP (di-n-butyl phthalate)  DEHP […] The post Fires* Tornadoes *Floods *Hurricanes *Volcanos and Earthquakes. Natural Disasters or on PURPOSE? What is the Ring of Fire? appeared first on Psychopath In Your Life.

This week we converse with Jeff & Tony! How our careers and our hobbies blend to make a brand. Leaning on your strengths and being aware of your weaknesses. Before we get all serious you know we mix some silly dialogue for the DBP listenership with plenty of golf talk. A full recap of the RBC Canadian Open and more of Its All A Blur Tour updates. We've never fished for more sponsorships than this episode so yea I guess we're open to hear offers. (Not really tho) Greenview memories & the road we traveled to get here. How the money turned me into a terrible human being…  We also have never talked more about road maintenance and design. Jeff incriminates hisself on this episode. What is your biggest asset? What are you willing to do to protect it? I hate to give you guys a cliff hanger episode but it is what is it, we will talk next week

Nesse episódio do Journal Club, apresentamos artigos discutindo sobre o risco de perfuração intestinal espontânea com uso de corticoides e indometacina, as taxas de bilirrubina em prematuros, a importância de treinar a equipe em cuidados paliativos neonatais e quais desfechos associados a DBP são mais importantes para os pais. Você pode ter acesso aos artigos na íntegra acessando nosso site: https://www.the-incubator.org/portuguese/Se estiver gostando do nosso Podcast, por favor deixe sua avaliação no seu aplicativo preferido.Se quiser nos mandar sugestões, comentários, críticas e elogios, manda um e-mail pra gente: incubadora@the-incubator.orgNão esqueça: você pode ter acesso aos artigos do nosso Journal Club no nosso site: https://www.the-incubator.org/podcast-1 Se estiver gostando do nosso Podcast, por favor deixe sua avaliação no seu aplicativo favorito e compartilhe com seus colegas. O nosso objetivo é democratizar a informação. Se quiser entrar em contato, nos mandar sugestões, comentários, críticas e elogios, manda um e-mail pra gente: incubadora@the-incubator.org

The following question refers to Section 4.7 and Table 18 of the 2021 ESC CV Prevention Guidelines. The question is asked by CardioNerds Academy Intern Student Dr. Shivani Reddy, answered first by Fellow at Johns Hopkins Dr. Rick Ferraro, and then by expert faculty Dr. Roger Blumenthal.Dr. Roger Blumenthal is professor of medicine at Johns Hopkins where he is Director of the Ciccarone Center for the Prevention of Cardiovascular Disease. He was instrumental in developing the 2018 ACC/AHA CV Prevention Guidelines. Dr. Blumenthal has also been an incredible mentor to CardioNerds from our earliest days.The CardioNerds Decipher The Guidelines Series for the 2021 ESC CV Prevention Guidelines represents a collaboration with the ACC Prevention of CVD Section, the National Lipid Association, and Preventive Cardiovascular Nurses Association.Enjoy this Circulation 2022 Paths to Discovery article to learn about the CardioNerds story, mission, and values. Question #28 Mr. A. C. is a 78-year-old gentleman with a long-standing history of HTN receiving antihypertensive medications & dietary management for blood pressure control. What is the target diastolic blood pressure recommendation for all treated patients such as Mr. A.C.?A< 80 mmHgB< 90 mmHgC< 70 mmHgD< 95 mmHgE< 100 mmHg Answer #28 Explanation The correct answer is A: DBP < 80 mmHg Blood pressure treatment targets: when drug treatment is used, the aim is to control BP to target within 3 months. Blood pressure treatment targets in the 2021 ESC Prevention guidelines are more aggressive than previously recommended, as evidence now suggests the previously recommended targets were too conservative, especially for older patients. The magnitude of BP lowering is the most important driver of benefit. ·       It is recommended that the first objective of treatment is to lower BP to

Paul is back and it wouldn't be an episode of The DBP without some philosophical ideologies. We cover his recovery from a subarachnoid hemorrhage. What lead to such a horrific medical emergency & everything that comes with a near death experience. Beauty in relation to sadness. "Mother Nature is a chaotic bitch." AI (not Allen Iverson) is something I wanted to talk with Paul about and here it is. Artificial Intelligence and our relation to monetizing data, and the manipulation that comes with simply owning computers. Paul is the man, the myth, the legend that you wanna hear his opinion on these hot topics. Thank God for him, his health, and his unique point of view. Enjoy

This week we are welcoming DBP captain Austin again. One of our favorite guests and we capture a truly great conversation. We update the audience with our general growth and evolution. Straight disrespect about the city to the Detroiter's that vacant it, never a good idea. Casino etiquette and how to walk out up up. Roulette wheels and poker rooms, we gotta get our lives together family. Did you know you can't deposit money in a casino atm? Rest in heaven Doyle Brunson. Flashing the burner on IG live. Bird shot, bird shot, buck shot! Racial Nickles & affirmative action. Denver vs LA western conference finals breakdowns and debates. The wondering mind and how to tame it. How to deal with scammers via Amazon, PayPal etc. Play a Karen when talking to debt collectors. How do we get Lebron Stans to take full accountability? Summer events and the money spent on them. Kim K bought Ice Spice for a day.. Do you believe someone will treat you how you treat them. What Austin did to the guy who stole his phone. Top G update! The public eye bounce back, separating unauthentic personalities. Knowing the man character in your story is you. You are only a real man when you're responsible for others.STAY BLESSED DBP FAMILY❤️‍

Executive Director Alice Clark and Program Director Lindsey Payne Johnstone joined us to tell about the role DBP plays in keeping our downtown core vibrant and thriving.  The Downtown Bellingham Partnership (a 501(c)(3) nonprofit) is famous for is events - First Fridays, Wine Walk, and especially the iconic Downtown Sounds, a free-admission outdoor concert series which draws thousands of people and closes three city blocks over five Wednesdays in the summer.  But the DBP crew is responsible for so much more: administrating micro grants for storefront improvements, public art efforts, graffiti cleanup, spring floral baskets, and safety patrols. Over the past three years, they've also seen their role expand further into business development support and advocacy, including networking with other downtown organizations down the I-5 corridor. We talked about the fentanyl crisis, how the empty office buildings mean less breakfast & lunchtime foot traffic for small businesses, and the emotional work of advocating for their constituents.  About the show: https://www.instagram.com/building.bellingham/

Another classic! First and foremost I made a boo boo on the production side but with my doctorate in audio engineering we've made adjustments. Welcoming the Besteas podcast hosts and having a long discussion about creating & producing. Is being a parent enough or do we have addition callings? What difficult things do you do to evolve? Who's the villain in your story to be better? More & more boundaries. Who do you decide is worthy of your energy? Are men to blame for all of our problems? "putting the work in to love Each other.." -Dom   Who's your partner that will choose you not allow you to run away???"IF I GIVE UP ALL MY HOE"S FOR YOU AND WE BREAK UP, YOU OWE ME SOME HOE'S..."Is the grass greener on the other side? (ladies) When you meet the right person you will change.

Today we're speaking with Christina Jones of DBA Media LLC. Christina Jones is the Senior Vice President of Talent at Digital Brand Architects. In her role as SVP, Jones has led and built an additional management sector at DBA that continues to lead DBA's mission to amplify strong multi-hyphenated voices in the digital space. Jones began her career in the space eight years ago, quickly garnering wide acknowledgment and credibility for representing and building pathways for talent who push against traditional societal standards. During her time at DBA, Jones' clients' careers have sky-rocketed. In 2018, it was announced that Jones' client Patrick Starrr in partnership with Digital Brand Products, secured a $10M investment to begin his own makeup brand One/Size Beauty. In total, Jones' management team has secured over 20+ high-value business opportunities with DBP, garnering multi-million dollars of revenue through these partnerships. Additionally, Jones' clients like Kier Gaines, Achieng Agutu, Terrell and Jarius, and Yasmin Maya have been recognized by the likes of Oprah Winfrey, The White House, Good Morning America, The Today Show, Michelle Obama, and more for their advocacy around Black rights, LGBTQ+ and US citizenship. Prior to DBA, Jones' career started as a manager at The Collective (Studio71), and later, at 21 years old, she became one of the youngest agents in history when she was announced as an Endorsement Agent at APA, securing eight figures in partnerships during her tenure for clients of the agency. She was also a part of UTA's acquisition of Digital Brand Architects in 2019 and has grown from a Director to Senior Vice President of the company within four years of joining DBA. Jones resides in Los Angeles and has a Bachelor's Degree in Television Production with a minor in Digital Strategic Communications and Film. TIMESTAMPS [10:42] Christina's background [18:07] Christina's talent management introduction [22:31] Identifying the right talent to represent [25:52] How to retain a talent [28:00] How to retain your talent manager [30:36] Barriers in the talent management industry & solutions [35:28] Christina's advice on working with marketing agencies [38:00] Christina's advice to managers on how to negotiate pricing for their talents [40:57] Tips on how to pick the right talent for marketing opportunity [46:00] Growth opportunities for Influencers [49:08] Guide on how to pick additional revenue streams for influencer  [42:07] Advice to Influencers who don't have capital to hire a talent manager [51:49] Christina's thoughts on trends in the industry [57:21] Christina: What other career opportunities would you have pursued aside from being a talent manager? [59:19] False misconceptions about DBA [01:01:45] True misconceptions about DBA   Connect with her: LinkedIn Want to join WIIM's Membership? Check out our websiteDon't forget to follow us on Instagram --- Send in a voice message: https://podcasters.spotify.com/pod/show/wiim/message Support this podcast: https://podcasters.spotify.com/pod/show/wiim/support

The Bored (ass) Bills are truly back for a whole new Millennium - excuse me: BILL-ennium! - to once again talk sh*t about the hits! On this ep, the hits in question are the Hot 100 Billboard Number Ones of 2000 - featuring eternal classics from new blood acts like Destiny's Child, Enrique Iglesias, N*Sync(sp?) and Christina Aguliera(sp?), as well as established industry legends like Janet J., Madonna, Santana, and Mariah Carey; plus even a little bald representation from our friends over at Vertical Horizon! The Good, the Bad & the Ugg-ly (remember Ugg boots lol? So 2000s!) Your Presenters of DBP discuss them all! 

On this episode Uly Monster, 2nyce & the whole DBP Family celebrate our 2 year anniversary with the legend Friks84. Here we are 2 years momma !! Lol its been an amazing journey & learning experience for all of us. We want to say thank you to each & every one of you that follow DBP & give us the energy to keep going. No pare sigue sigue !! LOl  As we proceed to give you what you need Friks84 is in the building tonight & this man is a Monster artist. In fact Derick G & Friks84 were the ones that created my infamous Monster Logo & reveal. This is another great one with a great one. So Grab your popcorn, sit back relax & DONT BLINK !!  #dontblinkpodcast  #itsown  #friks84    DONT BLINK PODCAST SITE: https://dontblinkpodcast.net https://www.instagram.com/uly_monster/ ​​https://www.instagram.com/2nycelive/ https://www.instagram.com/friks84/ https://www.instagram.com/historymakers02/ https://www.instagram.com/monsterbrandglobal/ https://www.instagram.com/dontblinkpodcast/ Thank you for watching | LIKE . COMMENT . SUBSCRIBE . SHARE |

Ep. 83 featuring Free & Montana...We work and workers get special privileges.

DANNY IS BACK!!!Live from Plymouth Roc Recording Co...This week we cover:How to podcastCritizisim Transport & LogisticsDAMAGESGood & Bad EmployeesMy niece

Videos: How Technology Is Negatively Affecting You (12:00) Stunning AI shows how it would kill 90%. w Elon Musk. (15:58) What's Coming Is WORSE Than A Recession” – Chamath Palihapitiya (15:03) Heather Mac Donald On How The Delusion of Diversity Destroys Our Common Humanity(11:02) Potatoes can be part of a healthy diet Louisiana State University, November 18, 2022 When we think of healthy vegetables, we don't think of potatoes, but we should. Potatoes have developed a reputation for causing weight gain and an increased risk for type 2 diabetes, and often find themselves on a list of foods to avoid, especially for individuals with insulin resistance. However, a new study from Pennington Biomedical Research Center at Louisiana State University, published in the Journal of Medicinal Food, says that potatoes actually did not increase that risk, are filled with key nutrients, and packed with health benefits. Candida Rebello, PhD, an assistant professor at Pennington Biomedical, said, “We demonstrated that contrary to common belief, potatoes do not negatively impact blood glucose levels. In fact, the individuals who participated in our study lost weight.” “People tend to eat the same weight of food regardless of calorie content in order to feel full,” Rebello explained. “By eating foods with a heavier weight that are low in calories, you can easily reduce the number of calories you consume. The key aspect of our study is that we did not reduce the portion size of meals but lowered their caloric content by including potatoes. Each participant's meal was tailored to their personalized caloric needs, yet by replacing some meat content with potato, participants found themselves fuller, quicker, and often did not even finish their meal. In effect, you can lose weight with little effort.” The study involved 36 participants between the ages of 18 and 60 who were overweight, had obesity, or insulin resistance. Insulin resistance refers to a health condition in which the body's cells do not respond well to insulin and glucose does not enter into the cells to make energy. Insulin resistance is linked to obesity, high blood pressure, high cholesterol, and type 2 diabetes Participants were fed precisely-controlled diets of widely available common foods including either beans, peas, and meat or fish, or white potatoes with meat or fish. Both diets were high in fruit and vegetable content and substituted an estimated 40% of typical meat consumption with either beans and peas or potatoes. Previous studies have shown that eating beans and peas improves blood glucose levels in individuals with newly diagnosed type 2 diabetes. To increase the dietary fiber component of the potatoes, they were boiled with the skin intact and then refrigerated between 12 and 24 hours. Potatoes were incorporated into the main lunch and dinner entrées, and served together with sides such as mashed potatoes, oven-roasted potato wedges, potato salad, and scalloped potatoes with lunch and dinner entrees. “We prepared the potatoes in a way that would maximize their fiber content. When we compared a diet with potatoes to a diet with beans and peas, we found them to be equal in terms of health benefits,” Rebello said. “People typically do not stick with a diet they don't like or isn't varied enough. The meal plans provided a variety of dishes, and we showed that a healthy eating plan can have varied options for individuals striving to eat healthy. In addition, potatoes are a fairly inexpensive vegetable to incorporate into a diet.” (NEXT) Celery Seed Extract Lowers High Blood Pressure in Human Study University of Chicago Medical Center, November 8, 2022 Drugs to lower blood pressure are among the most commonly prescribed medicines in the U.S. More than 678 million blood pressure prescriptions were filled in 2010. All of the current classes of blood pressure lowering drugs possess significant side effects.A recent study with a special extract of celery seed extract indicates that it may produce clinical results without producing the side effects that plague current drug treatment. Celery seed extract contains an important compound known as 3-n-butylphthalide, or 3nB for short, that is also responsible for the characteristic flavor and odor of celery. 3nB was discovered as the active component of celery in response to investigations by researchers seeking to explain some of the medicinal effects of celery, including the lowering of blood pressure and the relief of arthritis. 3nB first drew significant scientific attention when researchers identified it as the factor in celery responsible for the blood pressure lowering effect of celery. The research was prompted by one of the researcher's father, who after eating a quarter-pound of celery every day for one week observed his blood pressure dropped from 158 over 96 to a normal reading of 118 over 82. A recent human study evaluated the efficacy of a standardized extract of celery seed supplying 85 percent 3nB in 30 patients with mild to moderate hypertension. The dosage was 150 mg per day. The results showed a statistically significant decrease in both systolic (SBP) and diastolic blood pressure (DBP) compared to baseline measurements. The change at week six for the SBP was 8.2 mmHg and for the DBP was 8.5 mmHG. No side effects were reported. These results indicate that celery seed extract may produce the greatest blood pressure-lowering effects in natural products available on health food store shelves. A major advantage of celery extract over conventional drugs used in high blood pressure is that drugs like beta-blockers, angiotensin converting enzyme (ACE) inhibitors, and calcium channel blockers tend to significantly lower the blood flow to the brain While this effect is helpful in reducing the likelihood of stroke, it often leaves patients taking these drugs feeling tired, depressed, dizzy, and forgetful. Celery extract on the other hand has actually been shown to not only help prevent stroke in animal studies, but also improve blood flow as well and act to protect the brain and enhance energy production with the brain. (NEXT) Exercise during pregnancy gives newborn brain development a head start University of Montreal, November 10, 2022 As little as 20 minutes of moderate exercise three times per week during pregnancy enhances the newborn child's brain development, according to researchers at the University of Montreal and its affiliated CHU Sainte-Justine children's hospital. This head-start could have an impact on the child's entire life. “Our research indicates that exercise during pregnancy enhances the newborn child's brain development,” explained Professor Dave Ellemberg, who led the study. “While animal studies have shown similar results, this is the first randomized controlled trial in humans to objectively measure the impact of exercise during pregnancy directly on the newborn's brain.We hope these results will guide public health interventions and research on brain plasticity. Most of all, we are optimistic that this will encourage women to change their health habits, given that the simple act of exercising during pregnancy could make a difference for their child's future.” Not so long ago, obstetricians would tell women to take it easy and rest during their pregnancy. Recently, the tides have turned and it is now commonly accepted that inactivity is actually a health concern. “While being sedentary increases the risks of suffering complications during pregnancy, being active can ease post-partum recovery, make pregnancy more comfortable and reduce the risk of obesity in the children,” Curier explained. “Given that exercise has been demonstrated to be beneficial for the adult's brain, we hypothesized that it could also be beneficial for the unborn child through the mother's actions.” To verify this, starting at the beginning of their second trimester, women were randomly assigned to an exercise group or a sedentary group. Women in the exercise group had to perform at least 20 minutes of cardiovascular exercise three times per week at a moderate intensity, which should lead to at least a slight shortness of breath. Women in the sedentary group did not exercise. The brain activity of the newborns was assessed between the ages of 8 to 12 days, by means of electroencephalography, which enables the recording of the electrical activity of the brain. “We used 124 soft electrodes placed on the infant's head and waited for the child to fall asleep on his or her mother's lap. We then measured auditory memory by means of the brain's unconscious response to repeated and novel sounds,” Labonté-LeMoyne said. “Our results show that the babies born from the mothers who were physically active have a more mature cerebral activation, suggesting that their brains developed more rapidly.” (NEXT) Keeping indoor humidity levels at a ‘sweet spot' may reduce the spread of COVID-19 Massachusetts Institute of Technology, November 14, 2022 We know proper indoor ventilation is key to reducing the spread of COVID-19. Now, a study by MIT researchers finds that indoor relative humidity may also influence transmission of the virus. Relative humidity is the amount of moisture in the air compared to the total moisture the air can hold at a given temperature before saturating and forming condensation. In a study appearing in the Journal of the Royal Society Interface, the MIT team reports that maintaining an indoor relative humidity between 40 and 60% is associated with relatively lower rates of COVID-19 infections and deaths, while indoor conditions outside this range are associated with worse COVID-19 outcomes. To put this into perspective, most people are comfortable between 30 and 50% relative humidity, and an airplane cabin is at around 20% relative humidity. The findings are based on the team's analysis of COVID-19 data combined with meteorological measurements from 121 countries, from January 2020 through August 2020. Their study suggests a strong connection between regional outbreaks and indoor relative humidity. In general, the researchers found that whenever a region experienced a rise in COVID-19 cases and deaths prevaccination, the estimated indoor relative humidity in that region, on average, was either lower than 40% or higher than 60% regardless of season. Nearly all regions in the study experienced fewer COVID-19 cases and deaths during periods when estimated indoor relative humidity was within a “sweet spot” between 40 and 60%. “There's potentially a protective effect of this intermediate indoor relative humidity,” suggests lead author Connor Verheyen, a Ph.D. student in medical engineering and medical physics in the Harvard-MIT Program in Health Sciences and Technology. “However, we find that maintaining an indoor relative humidity in that sweet spot—of 40 to 60%—is associated with reduced COVID-19 cases and deaths.”In all, they focused on 121 countries where COVID-19 outbreaks occurred. For each country, they also tracked the local COVID-19 related policies, such as isolation, quarantine, and testing measures, and their statistical association with COVID-19 outcomes. In warmer times, both outdoor and indoor relative humidity for each country was about the same, but they quickly diverged in colder times. While outdoor humidity remained around 50% throughout the year, indoor relative humidity for countries in the Northern and Southern Hemispheres dropped below 40% in their respective colder periods, when COVID-19 cases and deaths also spiked in these regions. (NEXT) Why Are Kids So Great at Learning? GABA Brown University, November 16, 2022 GABA is the abbreviation for the neurotransmitter γ-aminobutyric acid. In the study, published in the journal Current Biology, researchers explain GABA's crucial role in helping children process new information and prepare their brains to learn and store even more. “What we found is a rapid increase in GABA in children, associated with learning,” says lead study author Takeo Watanabe, a professor of cognitive and linguistic sciences at Brown University. The neurotransmitter GABA plays an important role in helping the brain consolidate new info, Watanabe says. It “stabilizes” the network so that subsequent learning doesn't override what was already there and defends knowledge against retrograde interference. Yet this kind of GABA inhibitory processing is not fully matured in children, he says. Kids have lower levels of GABA—it's why they have less inhibitory abilities and weaker impulse control than adults. So if GABA is necessary to set the brain up to learn consecutive items, and children have less GABA than adults, then how are children able to, as Watanabe puts it, “learn and learn and learn and learn?” Using an advanced imaging technique called functional MRS, they measured the concentration of GABA in early visual cortical areas before, during and after learning sessions. They then compared the concentrations between children (ages 8 to 11) and adults (ages 18 to 35). They found that before learning begins, the overall amount of GABA in children is indeed smaller than in adults, Watanabe says. However, the researchers found that children exhibited a rapid boost in GABA concentration in the second round of learning, while the concentration of GABA in adults did not change.The results of the experiments suggest that compared with adults, children exhibit more dynamic GABA-associated inhibitory processing, which more rapidly adapts to stabilize learning than in adults, the researchers conclude. (NEXT) Being comfortable with aging can benefit sex life University of Missouri, November 17, 2022 Researchers have long known that having a positive outlook can benefit a person's health.Now, a new study by the University of Missouri has found older adults who feel positively about aging have a healthier sex life—a finding that didn't surprise the researcher, who's been studying the benefits of the positive perceptions of aging.”We know positive perceptions of aging can be really beneficial, but when they are negative, they can be really detrimental. Negative perceptions of aging are linked to higher likelihood of cognitive decline, higher likelihood of cardiovascular disease and even shorter lifespans. We wanted to see how it would affect people's sexual relationships. As expected, thinking positively about the way you age can also lead to a healthy sex life.” “We found this relationship to be strong with both men and women,” Skoblow said. “With data from more than 1,100 couples, we were able to find that participants with a more positive perception of aging also had sex more frequently as well as increased satisfaction.” “It's possible that if people expect a steep physical decline as an inevitable part of aging, they could have anticipatory inhibitions. They stop enjoying themselves in the moment and could have less satisfying sexual encounters,” Skoblow said. “We also know that western cultures often have many youthful beauty ideals, so maybe people with more positive perceptions of aging don't buy into them as much, leading to a more satisfying sex life as their body begins to change.”

Videos: 1.Covid has torn apart our social fabric (Feat. Dr. Matt Strauss) 2.  A Christian Response to Wokeness (FULL VIDEO) | Noelle Mering | Leadership Institute (21:51) 3.  NBC News just SMEARED real journalists in shameful hit piece | Redacted with Clayton Morris (22:00) 4. COME HELL OR HIGH WATER! Four minutes of WOW! (talking about the shootings and blame)   Vitamin D deficiency directly linked to dementia University of South Australia, June 14, 2022 Dementia is one of the major causes of disability and dependency among older people worldwide, affecting thinking and behaviors as you age. But what if you could stop this degenerative disease in its tracks? A world-first study from the University of South Australia could make this a reality as new genetic research shows a direct link between dementia and a lack of vitamin D. Investigating the association between vitamin D, neuroimaging features, and the risk of dementia and stroke, the study found: low levels of vitamin D were associated with lower brain volumes and an increased risk of dementia and stroke genetic analyses supported a causal effect of vitamin D deficiency and dementia. in some populations as much as 17% of dementia cases might be prevented by increasing everyone to normal levels of vitamin D (50 nmol/L). Flaxseed supplements linked to improved blood pressure: Meta-analysis University of Medicine and Pharmacy (Romania), June 9, 2022 Supplements of flaxseed may effectively management blood pressure, says a new meta-analysis of 15 clinical trials. Data from 1,302 participants indicated that flaxseed supplements are associated with significant reductions in both systolic and diastolic blood pressure of about 2.85 mmHg and 2.39 mmHg, respectively. “The results obtained in the present meta-analysis – a decrease of 2.85/2.39 mmHg after flaxseed supplementation – might be valuable for the hypertension management using nutraceuticals, since Heart Outcome Evaluation study demonstrated that a 3.3/1.4 mmHg reduction was associated with a 22% decline of relative risk of cardiovascular mortality,” wrote scientists from Romania, Iran, Australia and Poland in Clinical Nutrition . The scientists also report that supplementation for longer than 12 weeks resulted in even greater reductions in systolic and diastolic blood pressure of 3.10 mmHg and 2.62 mmHg, respectively, compared to trials of shorter duration. The potential biological mechanism are not completely understood, said the researchers, but could be linked to the lignan content of flaxseed. Specifically, a lignan named SDG is known to be an angiotensin-converting enzyme (ACE) inhibitor. ACE inhibitors work by inhibiting the conversion of angiotensin I to the potent vasoconstrictor, angiotensin II, thereby improving blood flow and blood pressure. Finally, an arginine-rich protein fraction (KCl-F1) from flaxseed may also impact blood pressure. Flaxseed powder supplements were found to affect systolic blood pressure (SBP) and diastolic blood pressure (DBP), whereas flaxseed oil preparations only affected DBP. On the other hand, lignan extracts was not associated with any changes in SBP and DBP, they said. Keep calm and carry on — for the sake of your long-term health Penn State University, June 9, 2022 Reacting positively to stressful situations may play a key role in long-term health, according to researchers. In a study measuring adults' reactions to stress and how it affects their bodies, researchers found that adults who fail to maintain positive moods such as cheerfulness or calm when faced with the minor stressors of everyday life appear to have elevated levels of inflammation. Furthermore, women can be at heightened risk. Nancy Sin, in the Center for Healthy Aging, Penn State and her colleagues showed that the frequency of daily stressors, in and of itself, was less consequential for inflammation than how an individual reacted to those stressors. “A person's frequency of stress may be less related to inflammation than responses to stress,” said Sin. “It is how a person reacts to stress that is important.” In the short-term, with illness or exercise, the body experiences a high immune response to help repair itself. However, in the long term, heightened inflammatory immune responses may not be healthy. Individuals who have trouble regulating their responses may be at risk for certain age-related conditions, such as cardiovascular disease, frailty and cognitive decline, Sin said. “To our knowledge, this paper is the first to link biomarkers of inflammation with positive mood responses to stressors in everyday life,” said Jennifer E. Graham-Engeland, associate professor of biobehavioral health, Penn State. For breast cancer prevention, diet quality matters Healthy, plant-based diet linked with lower cancer risk for postmenopausal women  Paris-Saclay University (France), June 14, 2022 Research shows that what we eat can influence our cancer risk, but it's not always clear which foods or dietary patterns are best for cancer prevention. Results from a new study suggest that the quality or overall healthiness of a person's diet may be key. The study, based on data from over 65,000 postmenopausal women who were tracked for more than two decades, found that a healthy plant-based diet was linked with a 14% lower risk of breast cancer while an unhealthy plant-based diet was linked with a 20% higher risk of breast cancer. The findings were consistent across all breast cancer subtypes. “These findings highlight that increasing the consumption of healthy plant foods and decreasing the consumption of less healthy plant foods and animal foods might help prevent all types of breast cancer,” said Sanam Shah, at Paris-Saclay University, Gustave Roussy, France, the study's lead author.  Previous studies have examined cancer risks associated with various dietary patterns such as the Western diet, the Mediterranean diet and vegetarian diets. Although some studies suggest diets with less or no meat consumption offer health benefits, results have been somewhat mixed. For the new study, researchers focused on differentiating between healthy plant-based foods — such as whole grains, fruit, vegetables, nuts, legumes, vegetable oils and tea or coffee — and plant-based foods the study categorized as less healthy including fruit juices, refined grains, potatoes, sugar-sweetened beverages and desserts. Regular exercise beneficial in suppressing inflammation in rheumatic disease Exercise results in physiological changes that decrease inflammation on a local and systemic level Ohio State University, June 12, 202 Research findings suggest that exercise transiently suppresses local and systemic inflammation, reinforcing the beneficial effects of exercise and the need for this to be regular in order to achieve clinical efficacy in rheumatic disease. These new research findings focused on the physiological changes created by exercise and their impact on inflammation. The researchers have found that exercise generates a true biological response and induces changes on a molecular level that stimulate anti-inflammatory effects. This in-vivo study measured the regulation and activation of NF-kB* in mice. NF-kB, a protein complex that controls many genes involved in inflammation, is found to be chronically active in many inflammatory diseases, such as inflammatory bowel disease and arthritis. The effect of exercise on the inhibition of NF-kB activation was identified as a transient effect, lasting only 24 hours after exercise.The role of exercise in inhibiting NF-kB activation was linked to the suppression of multiple pro-inflammatory cytokines.  Keeping the faith – or your willingness to push yourself – as you grow older Norwegian University of Science and Technology, June 14, 2022 So you could have become a pro footballer when you were younger, you say? Or really good at chess? Perhaps a world-renowned chef? Well, maybe not anymore, we think as we get older. And maybe that's actually okay. A research group has investigated how important the motivational factors for becoming really proficient at a skill change over the years. “We wanted to see how the passion, grit and belief that you'll succeed at getting better – your growth mindset – change with age and in relation to gender,” says Hermundur Sigmundsson, a professor at the Norwegian University of Science and Technology's (NTNU) Department of Psychology. “The passion for what you used to burn for declines. And so does the belief that you can succeed at becoming really good at it,” says Professor Sigmundsson. But this is where it is important to take hold of yourself and not give up. You might not become a world champion in anything, but you could still get really proficient if you go for it. Or at least better. “That's when it's important to maintain a growth mindset. You can't stop believing in growth even though you're getting older,” says Sigmundsson. “Passion and a growth mindset decrease with age, but the willingness to persevere increases if we look at the elderly population as a whole,” says Sigmundsson.