Podcasts about dc5

Headlines: SCOTUS to hear challenge to TikTok ban; USDA planned to give millions to nonprofit behind risky Wuhan Bat research as recently as this year; Education Department targets Christian Schools, career colleges; your tax dollars not at work; RFK Jr. grilling; progressive excusing violence; time for justice for pro-life prisoner and the DC5.See omnystudio.com/listener for privacy information.

Dr. Tyson Suljin is Deputy Chief of Critical Care Medicine and APD of the Internal Medicine Residency Program at Brook Army Medical Center. He presents a lecture entitled "Massive Transfusion" from the Critical Care perspective as part of the DC5 lecture series.

Dr. John P. Kress is a Professor of Medicine and Director of the Medical Intensive Care Unit at the University of Chicago Medicine. He presents a lecture entitled "Optimal Sedation Protocols in Mechanically Ventilated Patients" as part of the DC5 lecture series.

Disease/Critical Care Medicine at MedStar Washington Hospital Center presents a talk entitled "Ethical Issues in the ICU" as part of the DC5 lecture series.

Dr. Glenn W. Wortmann, FIDSA, FACP is the Section Director of Infectious Diseases at MedStar Washington Hospital Center and the Medical Director of Infection Prevention at the MedStar Institute of Quality and Safety.  He maintains academic appointments at Georgetown University Hospital as a Professor of Clinical Medicine and at the Uniformed Services University of the Health Sciences as Professor of Medicine. He presents a lecture entitled "Healthcare Associated Infections in the ICU" as part of the DC5 lecture series

Dr. Michael Keller is a Staff Clinician in the Critical Care Medicine Department at the NIH Clinical Center and Instructor of Medicine in Pulmonary and Critical Care Medicine at Johns Hopkins Hospital. He presents a lecture entitled "Heart-Lung Interactions in Spontaneous and Mechanical Ventilation" as part of the DC5 lecture series.

Dr. Chadi Abouassaly, Assistant Program Director of General Surgery at Medstar Washington Hospital Center and Associate Medical Director of the Trauma and Burn ICU presents a lecture on Pancreatitis as part of the DC5 lecture series.

Official visit season is just a few weeks away from kicking off in Columbus and across the nation, and Ohio State is set to welcome in some of the very best high school football players in America. With Ohio State's 2024 class already in good shape on the offensive side of the ball, Alex Gleitman of BuckeyeHuddle.com joins host Tom Orr to take a look at some of the top defensive prospects who are set to visit Columbus. 5-star Edge Dylan Stewart out of Washington, DC5-star Safety KJ Bolden from Georgia5-star Cornerback Charles Lester, III from Florida4-star Linebacker Kyngstonn Viliamu-Asa from California4-star Safety Peyton Woodyard, a current Georgia commitAnd many morePlus, how concerned should Buckeye fans be about 5-star WR commit Jeremiah Smith visiting Florida and Georgia?

Rockshow Episode 176 The Dave Clark Five The Dave Clark Five, also known as DC5, was a British rock and roll band that emerged during the 1960s as part of the British Invasion, a cultural phenomenon where British bands gained popularity in the United States. Formed in Tottenham, North London in 1959, the group mainly consisted of Dave Clark (drums), Mike Smith (vocals, keyboards), Lenny Davidson (guitar), Rick Huxley (bass), and Denis Payton (saxophone, guitar). The Dave Clark Five quickly gained fame with their distinct sound, characterized by prominent drums, electric organ, saxophone, and harmonized vocals. Their first UK hit was "Do You Love Me" in 1963, which was followed by a string of successful singles, including "Glad All Over," "Bits and Pieces," and "Catch Us If You Can." In 1964, "Glad All Over" dethroned The Beatles' "I Want to Hold Your Hand" from the top spot on the UK charts, further cementing their status as one of the leading British Invasion bands. The band appeared on the popular television show "The Ed Sullivan Show" more than a dozen times, solidifying their popularity in the United States. Throughout the 1960s, the DC5 continued to produce chart-topping hits in both the UK and the US, with memorable songs like "Because," "I Like It Like That," and "Over and Over." However, their popularity started to decline by the end of the decade. Although The Dave Clark Five disbanded in 1970, their influential role in the British Invasion left an enduring legacy on the development of rock and pop music. In 2008, the band was inducted into the Rock & Roll Hall of Fame, recognizing their significant impact on the music industry. https://daveclark5.com/ https://youtube.com/channel/UCVnXzbk3ZyeIicpX3x-LbaQ https://open.spotify.com/artist/2HBbky0Z08ZcCKVsXWbNE4?autoplay=true&source_application=google_assistant https://www.rockhall.com/inductees/dave-clark-five https://m.facebook.com/thedaveclarkfiveofficial/?wtsid=rdr_00qaEPXW0iLK4Slqf https://www.edsullivan.com/artists/dave-clark-five/ https://www.instagram.com/thedaveclark5/?hl=en https://www.instagram.com/the.dave.clark.five/?hl=en #DaveClarkFive #DC5 #BritishInvasion #60sRock #GladAllOver #BitsAndPieces #CatchUsIfYouCan #DC5Legends #DaveClarkFiveForever #RockAndRollHistory Park Dental Care 12419 101st Ave South Richmond Hill Queens (718) 847-3800 https://www.718DENTISTS.com Please follow us on Youtube,Facebook,Instagram,Twitter,Patreon and at www.gettinglumpedup.com https://linktr.ee/RobRossi Get your T-shirt at https://www.prowrestlingtees.com/gettinglumpedup And https://www.bonfire.com/store/getting-lumped-up/ Subscribe to the channel and hit the like button This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/rob-rossi/support https://www.patreon.com/Gettinglumpedup

Ntd evening news—03/03/20231. Murdaugh gets life sentence, declared guilty2. Wh defends Biden's decision to block dc law3. Gop sens. Visit tx, dems to visit border soon4. CPAC 2023 in Washington, DC5. Ag garland makes surprise visit to Ukraine

Tech seems to drive our lives these days. We can't do anything without some sort of device in our hand, at our fingertips, and even on our faces. But what does the tech industry actually do? Fran Racioppi asks Sultan Meghji for his opinion on all things tech. Sultan was the first Chief Innovation Officer at the Federal Deposit Insurance Corporation, he's a Scholar at the Carnegie Endowment for International Peace, a Fellow at the George Mason National Security Institute, a Member of the Bretton Woods Committee, and currently a Professor in the graduate programs at Duke University's Pratt Engineering School teaching AI, Web3 & Cybersecurity.They cover how FINTECH changed the banking industry and why Sultan's four innovation themes of Inclusion, Resilience, Amplification and Future are critical to implementing sustainable technology solutions in any business. Plus they cover how technology is being used in America's peer-to-peer competition with China. Learn more about him on LinkedIn and Twitter @sultanmeghji.Read the full episode transcription here and learn more on The Jedburgh Podcast Website. Subscribe to us and follow @jedburghpodcast on all social media. Watch the full video version on YouTube.Highlights:0:00 Welcome to Washington, DC5:00 What is tech and the technology revolution10:19 Leading technology at FDIC21:51 How FINTECH has advanced the banking industry27:53 Sultan's Four Innovation Themes: #1 Inclusion30:38 #2 Resilience35:13 #3 Amplification37:32 #4 Future40:27 How technology will enable competition with China 56:11 The status of cybersecurity in America1:01:07 Banking competition1:04:53 The next big tech innovation1:06:49 Three FoundationsQuotes: “We use tech and technology as a placeholder relative to how the caveman first had tools.” (5:24) “I fundamentally believe that humans plus technology are a different species than humans without technology.” (5:49)“We've started removing people from the processes of our civilization.” (5:32)“Starbucks would be a multi-hundred billion dollar bank if you just thought about the app as a bank.” (13:06)“Anybody who says they can predict the future has no idea what they're doing.” (37:36)“I want the United States to continue to be the backbone of the global financial system.” (39:10)“By the time we get to 2040-2050, all the telecommunications infrastructure globally will be Chinese.” (45:08)“It's always in cyber going to be easier to be an offensive actor than a defensive actor.” (58:11)Sultan's Three Daily Foundations to Success:Get really good sleepLearn something new and meaningfulDo something to get tiredThis episode is brought to you by Jersey Mike's, 18A Fitness & Compass Workforce Solutions

Dr. Jan Fouad is a recent graduate of the Pulmonary, Critical Care, and Sleep Medicine Fellowship at the Yale School of Medicine and is currently an Interventional Pulmonology Fellow at the University of Maryland. He presents a lecture entitled "Managing Massive Hemoptysis" as part of the DC5 lecture series.

Dr. Van Holden is an Associate Professor and Program Director of the Pulmonary and Critical Care Medicine Fellowship Program at the University of Maryland, School of Medicine. She presents a lecture entitled "Pleural Disorders" as part of the DC5 lecture series.

Dr. Narayana Sarma V. Singham, a Critical Care Cardiologist at Washington Hospital Center Heart & Vascular Institute presents a lecture entitled "Temporary Mechanical Circulatory Devices in the CICU" as part of the DC5 lecture series.

Case IH is now offering new size options for its centre-pivot DC5 series of disc mower conditioners. The configurations give growers greater performance in a smaller package. In this interview from the recent Farm Progress Show in Boone, Iowa, Case IH hay and forage equipment marketing manager Brian Spencer breaks down the new models. These... Read More

Had another great Die on that Hill segment with my friend Dave, known to us in the college days as DC5. This is a must listen. Dave gives some great insight and it's the first Hill where it's not music centric Dave is a very talented Actor and Musician and if you want to learn more about him, click the links below https://davidraymondclark.wordpress.com/ https://vimeo.com/338393567/ --- Support this podcast: https://anchor.fm/eric-stangeland/support

Dr. Janhavi Athale is a Critical Care physician and Hematologist/Oncologist at Mayo Clinic in Phoenix, Arizona. She presents a lecture on important "Hematologic and Oncologic Emergencies" as part of the DC5 lecture series.

CMO at La Jolla Pharmaceutical Company (LJPC). Prior to joining LJPC, Dr. Chawla was a Professor of Medicine at the George Washington University, where he had dual appointments in the Department of Anesthesiology and Critical Care Medicine as well as in the Department of Medicine, Division of Renal Diseases and Hypertension. Dr. Chawla presents a lecture on "Acute Kidney Injury" as part of the DC5 lecture series.

Dr. Michael Knight, the Associate Chief Quality and Population Health Officer and Head of Healthcare Delivery Transformation at the George Washington University presents on Health Disparities as part of the DC5 lecture series.

Dr. Ryan Maves, a Professor of Medicine and Anesthesiology at the Wake Forest School of Medicine presents on Meningitis and Encephalitis as part of the DC5 lecture series.

The Killjoys - Naïve (1977) Featuring Kevin Rowland, later to be the lead singer of Dexys Midnight Runners who had a huge worldwide hit with "Come On Eileen".  Normally I'd frown on such trend-hopping (this was just the first of many image reinventions to come) but when lightning strikes, it strikes. But it almost never strikes twice in pop music. And it didn't for him.  The Monkees - Head Radio Promo (1968) This is hilarious! Hearing Annette Funicello and a few members of the cast waxing about these "crazy" Monkees. Not The Monkees themselves, mind you. By the way, one of the shortest soundtrack albums I've ever seen. Each side clocks in at about 14 minutes with some incidental dialog.  The Dave Clark Five - Last Train To Clarksville (1971?)  Dave Clark had been approached (according to an interview I read from 1967) for the group to do the TV show which became The Monkees. But he turned it down because he did not see his band acting on screen the way the four actors who formed the 'made for TV band' called The Monkees would be asked to do. This particular recording appears on an out-of-print collection called "Unreleased Tracks", as were the other DC5 tracks on this show.  กุง กาดิน (Gunga Din) - ฉันจะร้องเพลง I Shall Sing) (196?)  Alice Swoboda - Potter's Field (1972) B-side of her second single. She released two.  Archie Bell & The Drells - Let's Groove (1975) Doc Severinsen - Bond Street (1968) Enoch Light - Bond Street (1969) Fórmula 7 - Bond Street (1968)  Hager Twins - Pizza Man (1979) Written by Eddie Rabbitt. Peoples Temple Choir - Welcome (1973)  Lafayette - Bond Street (1967)  Lazaro Salazar - Artuditu (1978) Men Without Hats - Antarctica (1982) Mouth and Macneal - ABC (1971) The Folkswingers (featuring Harihar Rao) - Raga Rock (1966)  Richard Simmons - Wake Up (1982) Richard Simmons - You Can Do It (1982)  The Styx - Soul Flow (1971) Not the Chicago prog band.  The Body Shop Trailer (1972)  The Colours - Cocaine (1968) The Dave Clark Five - Get It On Now (197?) The Dave Clark Five - Ruby Baby (197?)

Captain Daniel S. Chertow MD, MPH is an investigator in the Critical Care Medicine Department at the NIH Clinical Center and in the Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases. He serves as a senior officer in the United States Public Health Service (USPHS). He presents an interactive lecture on viral illness in the ICU with current and emerging threats as part of DC5 lecture series.

Dr. Andrew Shorr, MD, MPH, MBA, the Director of Pulmonary and Critical Care Medicine and Professor of Medicine at Georgetown Medstar Hospital presents a lecture on issues in nosocomial and ventilator associated pneumonia as part of the DC5 lecture series

Dr. Daniel Jamieson is an Associate Professor in the Division of Pulmonary, Critical Care and Sleep Medicine at Georgetown University Medical Center. Dr. Jamieson presents a lecture on poisonings and toxidromes as part of the DC5 lecture series.

On this day in 1964, three months after the Beatles' Empire Stadium concert, British hitmakers The Dave Clark Five arrived in Vancouver! A month after the Beatles smash February performance on the Ed Sullivan Show, the DC5 visited Sullivan and performed their first hit "Glad All Over". They returned the next week with two more songs and an encore of "Glad All Over". The group appeared on Ed Sullivan twelve times over a span of three years. Rock'n'roll competitor CKLG was just getting established and they were eager to take away some C-FUN listeners. To counter this I arranged for the Dave Clark Five to be available for an exclusive press conference right in the radio station's studio. Preparations were carefully made to ensure a minimum of interruption from avid fans who might invade the station. The first knowledge that fans had of the Dave Clark Five's presence in the studios was when they hit the air with their live press conference. CKLG complained bitterly to the show promoters... but to no avail. The Dave Clark Five — Dave Clark, Mike Smith, Rick Huxley, Dennis Peyton and Lenny Davidson — racked up some major hits between 1964 and 1967: "Glad All Over", "Bits and Pieces", "Do You Love Me", "Can't You See That She's Mine", "Because", "Any Way You Want It", "I Like It Like That", "Catch Us If You Can" and "Over and Over" Their last big hit, 1967's "You Got What It Takes", was released a couple of months before the Beatles' landmark "Sgt. Pepper's Lonely Hearts Club Band" album. Suddenly, music had changed and the formula hits stopped coming. The group disbanded in early 1970. Exactly 44 years after their first appearance on The Ed Sullivan Show, The Dave Clark Five was inducted into the Rock and Roll Hall of Fame in 2008 by Tom Hanks. They might have lacked the originality of The Beatles, but The Dave Clark Five did make a contribution. They were among the most memorable of the British acts that played Vancouver. Just a coincidence, but The Dave Clark Five just reissued their debut US album “Glad All Over” today! Remastered by Dave Clark at Abbey Road Studios and released on limited edition white vinyl, it includes the hit singles “Glad All Over”, “Do You Love Me”, “Bits and Pieces” and more. Pre-order your copy now at DC5.lnk.to/GladAllOverFA

The Dave Clark Five, sixties British Invasion band, and Rock 'n' Roll Hall of Fame inductees, had many fine ballads among their fourteen American-released albums. Some of them were hits, while others, perhaps overlooked, were superb also. Here are thirteen album cut/non-hit ballads by the DC5 (one from each album, except their first album, Glad All Over, which didn't contain any ballads). Enjoy!1. Bernadette (Album: 5 X 5 1967)2. 'Til the Right One Comes Along (Album: Weekend In London 1965)3. I'm Left Without You (Album: Coast To Coast 1964)4. I Still Need You (Album: Satisfied With You 1966)5. Whenever You're Around (Album: American Tour 1964)6. Scared of Falling in Love (Album: Try Too Hard 1966)7. That's How Long Our Love Will Last (Album: I Like It Like That 1965)8. Julia (Album: If Somebody Loves You 1970)9. I'll Do the Best I Can (Album: Everybody Knows 1968)10. No One Can Break A Heart Like You (Album: 5 X 5 1964-1969)11. Forever and a Day (Album: The Dave Clark Five Return! 1964)

Dr. John Sherner, board-certified pulmonary and critical care physician at MedStar Washington Hospital Center, where he is currently Chairman of the Department of Medicine presents on management of massive pulmonary embolism as part of the DC5 lecture series.

Dr. Jenelle Badulak, an emergency physician and intensivist at the University of Washington Medical Center presents a lecture on ECMO indications and complications as part of the DC5 lecture series.

Dr. Anantha K. Mallia, Assistant Professor of Emergency Medicine and Associate Program Director of the Pulmonary and Emergency Medicine-Critical Care Fellowship at MedStar Washington Hospital presents on critical care ultrasound for the assessment of the LV and RV as part of the DC5 lecture series.

Adam and the Ants [00:30] "Antmusic" Kings of the Wild Frontier Epic NJE 37033 1980 Memories of heavy rotation in my adolescent brain. Kiss [04:11] "Anyway You Want It" Kiss Alive II Casablanca NBLP 7076-2 1977 Paul does an ok job handling this DC5 hit (https://youtu.be/oiC-gowaJms). Culture Club [06:43] "Do You Really Want to Hurt Me" Kissing to Be Clever Epic ARE 38398 1982 Made it to number 2 on the Hot 100. Nadja & Galena [10:19] "Trying" Konstruktion Adagio830 #63 2011 A mighty fine collaboration/ Al Kooper and Shuggie Otis [13:51] "Double or Nothing" Kooper Session Columbia CS 9951 1969 Solid cover of this Booker T classic with 15-year-old Shuggie Otis on geetar! Shogin Hogiwara [16:13] "Shin-Takasago" The Koto Music of Japan Nonesuch HS-72005 1965 Based upon a famous Noh drama about the seaside town of Takasago. The New Koto Ensemble of Tokyo [18:21] "Spring" Koto Vivaldi Angel Records SQ-37450 1977 If anyone has a quadrophonic system setup, I'll be happy to bring this over for a listening session. I bet it sounds pretty dope. Krallice [26:09] "Timehusk" Krallice Gilead Media ELD-023 2019 A fine reissue of this debut NYC black metal debut on smoky green vinyl from Gilead Media. Love and Rockets [32:20] "Lucifer Sam" Kundalini Express Beggars Banquet BEG 163 T 1986 Ride that flanger! The lads taking a fair pass at the Pink Floyd classic. L.A. Witch [35:39] "Kill My Baby Tonight" L.A. Witch Suicide Squeeze SSQ155 2017 Side one, track one from the amazing debut from the amazing L.A. Witch on amazing translucent pink marbled vinyl. Nat King Cole [39:27] "The Girl from Ipanema" L♥︎O♥︎V♥︎E Capitol Records T 2195 1965 If it's Spring up here, it must be Fall down Ipanema way. Deerhoof [42:21] "Big House Waltz" La Isla Bonita Polyvinyl Record Company PRC-286 2014 One of my favorite bands with one of my favorite albums from 2014 on lovely yellow vinyl. LA Vampires & Zola Jesus [45:46] "In the Desert" LA Vampires Meets Zola Jesus Not Not Fun Records NNF195 2010 Noise dub for everyone! Nick Lowe and Rockpile [48:01] "Love So Fine" Labour of Lust Columbia JC 36087 1979 Nick Lowe and the boys having some fun on the closing track of this album. Labour of Lust made it to number 32 on the Billboard 200, largely on the strength of "Cruel to Be Kind". Music behind the DJ: "VIVALDI: Fugue (from the Estro Harmonico Op. 3, No. 11, arranged for organ by J.S. Bach)" by The Swingle Singers

Paul McCarthy is in shambles! The third in our “Better than the Beatles” series features the Dave Clark Five, the southern rivals of the Fab Four. Both Erik & Weldon list their reasons why the DC5 are superior in every way and scientists and philosophers alike have described their logic as “airtight.” Our discussion of “Bits and Pieces” (5:24) reveals Dave to be a true 60s auteur who beats the Beatles in revolutionary strategy. We then break down how “Anyway You Want It” (44:55) is a sterling example of the two-minute Tottenham symphony which still echoes in our collective ears, and  Erik explains how Mike Smith is the Serpentor (GI Joe fans will understand...). “Nineteen Days” (1:16:09) is a ‘countdown' song that distorts time and space, as our appreciative garage philosophers assert. And finally, Weldon contemplates the bleak, organ-less musical landscape of today when we talk about “Come Home” (1:39:10), and Erik points out the literal heights the DC5 could reach, compared to the Liverpool losers. 

Exclusivité - Arnaud de Bermingham, président de fondateur de Scaleway, nous dit tout - ou presque... - sur la pratique de l'effacement sur le dernier datacenter DC5. Cette interview fait suite à notre article "Scaleway a pratiqué le premier effacement de puissance piloté de son histoire"  

Vous aussi vous vous demandez à quoi ressemble un centre de donnée ?On a eu la chance d'en visiter un grâce à Scaleway.On en discute dans ce podcast.Profiter de 30€ et essayer le cloud de Scaleway :https://www.compagnons-devops.fr/cloud-scalewayBienvenue, chers compagnons sur Radio DevOps.La Baladodiffusion des Compagnons du DevOps.Le podcast en français dédié à notre mouvement.Les liens :Nous n'avons pas pu prendre de photos pour des raisons de confidentialité mais lafibre.info en Octobre 2015 on pu faire un reportage photo sur le DC3 :https://lafibre.info/scaleway/dc3-iliad/Le journal du Net à pu faire un reportage sur le DC5 : https://www.journaldunet.com/solutions/cloud-computing/1422270-au-coeur-du-data-center-dc5-de-scaleway-taille-pour-les-gafam/Nos émissions :

This episode is sponsored by dungeonnotebook.com - makers of the Tome of Delving. Keep track of character stats, spells, wild shapes, inventory - and a bunch of other stuff as well as the adventure itself in this hardcover notebook. Use discount code DC5 at checkout to get $5 off your purchase between now and 2/29/20. On this weeks episode we talk about the Unearthed Arcana that came out last week and what we think of the new subclasses it introduces for the Bard, Cleric, and Sorcerer. After that we discuss player character romance and why one of us is cool with it and the other is hesitant. Lastly we answer a listener question from our friend Dallas about our first encounter with a dragon as both a player and DM. If you would like your question, topic, or story read on the show send them in to DifficutlyClass@gmail.com!

RU58841 vs. Finasteride. As of now RU58841 is the most commonly used topical anti-androgen used for hair loss prevention, and Finasteride is the most commonly used 5α-Reductase inhibitor for hair loss prevention. Which is better for hair loss prevention? This is a common question I get asked and a dedicated post is long overdue. https://youtu.be/p39W1nBhxYE Study Comparing RU58841 Vs. Finasteride Head To Head While there are tons of anecdotal reviews comparing Finasteride to RU58841, there is very little scientific data for us to refer to. There is some though that is worth delving into. In this study, Finasteride was stacked up against RU58841 to see which would be more effective for hair loss prevention, and how much each would impact systemic hormone levels [R]. RU58841 was applied either in a 5% solution, a 0.5% solution, or just a vehicle with no RU58841 in it for 6 months to the bald scalp of 10 stump-tailed macaques. The 5% solution was applied to 4 of the 10 bald stump-tailed macaques, the 0.5% solution was applied to 3 of the 10 bald stump-tailed macaques, and the vehicle with no RU58841 was applied to the last 3 of the 10 bald stump-tailed macaques. The common dosing protocol for RU58841 is typically a 5% solution applied to androgenic alopecia affected areas, so this study was right in line with what we would want to see. Oral Finasteride was given in a dose of 1 mg/kg/day for 6 months to 10 bald stump-tailed macaques. An oral placebo was also given to 10 bald stump-tailed macaques. Male stump-tailed macaques weigh on average between 9.7–10.2 kg, so that would equate to a Finasteride dosage of roughly 10 mg orally per day. This dosage greatly exceeds the point of diminishing returns with Finasteride use, so this is also a great way for us to compare the efficacy of a standard dose of RU58841 to a maxed out dose of Finasteride. The stump-tailed macaque has shown to be a suitable biological model for human androgenetic alopecia as it possesses hereditary balding characteristics similar in many respects to that of androgenetic alopecia in humans [R]. Results Skin biopsies for micromorphometric analysis (folliculogram) were taken at 0 and 6 months for Finasteride treated macaques and at 0 and 4 months for RU58841 treated macaques. The amount of anagen follicles (hairs in the active growth phase) and vellus follicles (short, thin, and barely noticeable hairs) enlarged to terminal size were compared to those in pre-treatment stages. Anagen follicles increased an average of 88% with Finasteride. Anagen follicles increased an average of 103% with 5% strength RU58841. The growth of vellus follicles to terminal size (thick, strong, pigmented hairs that have fully matured) was 12% with Finasteride. The growth of vellus follicles to terminal size was 26% with 5% strength RU58841. The 0.5% strength RU58841 solution induced almost no effect. Expectedly, the Finasteride placebo induced no effect. The 5% strength RU58841 solution induced the most hair growth after only 2 months of treatment. RU58841 was given less time to work and still significantly outperformed Finasteride in this study. Although Finasteride significantly reduced DHT levels, DHT remaining and produced by Type I 5α-reductase isoenzyme still contributed to hair follicle miniaturization. Because Testosterone and DHT both bind to the androgen receptor, a locally sufficient dose of an "AR blocker" (topical anti-androgen) appears to suppress Testosterone and DHT induced follicular regression more effectively than 5α-reductase inhibition. Systemic Effects Plasma RU58841 and metabolites (10-20 ng/ml) were detected in 2 of the stump-tailed macaques that were applied the 5% strength RU58841 solution at the 3 month mark of treatment. Only 1 of the stump-tailed macaques had detectable plasma RU58841 and metabolites at at the 6 month mark of treatment. RU58841 had no significant impact on serum DHT or Testosterone levels at any point. Finasteride decreased serum DHT levels by about 70%, and Testosterone levels increased as a result of the 5α-reductase blockade. If Estrogen levels were assessed in the Finasteride treated group, their Estrogen levels would have showed significant elevation as well as a result of increased aromatization. My Concluding Thoughts On This Study This study shows that RU58841 can go systemic when topically applied, although there is no effect on endogenous androgen levels. First of all, I do believe that RU58841 can go systemic, in fact, I think it is an inevitable outcome. However, the degree to which it goes systemic and if the amount that goes systemic will cause anti-androgenic side effects will be based on several factors. These factors include but are not limited to endogenous androgen production, sex hormone metabolism, androgen receptor density and expression, scalp skin porosity, the dosage used, if there are open wounds on the scalp or not, the vehicle used, frequency of administration, and more. Does this ensure side effects? No. However, applying anything to your skin with a low enough molecular weight to be absorbed and not expecting it to go systemic at all is wishful thinking. The molecular weight of RU58841 is 369.34 g/mol [R]. 1 Da (dalton) = 1 g/mol. The molecular weight of a compound must be under 500 Dalton to allow skin absorption (which RU58841 is) [R]. With that being said, RU58841 is well tolerated by the majority of users for a reason. In the study, at the 3 month mark 2 of the stump-tailed macaques had detectable plasma RU58841 and metabolites. By the 6 month mark, only 1 of the stump-tailed macaques had detectable plasma RU58841 and metabolites. If there was a cumulative drug effect we would have seen more animals with detectable metabolites after an additional 3 months of dosing, not less. What most fail to consider is that RU58841 is non-steroidal and acts as a competitive silent antagonist of the androgen receptor. This means that even if RU58841 goes systemic, by creating a blockade of the androgen receptor, RU58841 prevents the negative feedback androgens would normally create via the hypothalamic–pituitary–gonadal axis (HPG axis) in men. By binding to androgen receptors, RU58841 will induce anti-androgen effects without reducing serum androgen levels in the body. Finasteride on the other hand works by directly crushing DHT levels rather than by occupying androgen receptors. The ideal treatment would be a topical non-steroidal anti-androgen or SARM with a high binding affinity, and harmless metabolites void of anti-androgenic activity upon systemic absorption. Achieving Complete Hair Loss Protection By Addressing The Androgen Receptor, Not Just 5α-Reductase When you inhibit 5α-Reductase with Finasteride or Dutasteride, serum Testosterone and Estrogen levels increase will increase. A common mistake is to ignore the fact that scalp Testosterone levels rise dramatically after inhibiting 5α-Reductase. This occurs to an even greater degree with Dutasteride use, and I believe is the reason why some men experience accelerated hair loss after switching from Finasteride to Dutasteride. Typically, most men will see better results with Dutasteride as scalp DHT is almost always going to be more of a problem than scalp Testosterone. However, the consequent spike in scalp Testosterone levels with Dutasteride use is significant, and Testosterone will bind to androgen receptors and induce miniaturization just the same. 5 mg of Finasteride resulted in a 23% increase in scalp Testosterone levels with a concurrent 41% suppression of scalp DHT levels. 0.5 mg Dutasteride resulted in a 99% increase in scalp Testosterone levels with a concurrent 51% suppression of scalp DHT levels. This is why the androgen receptor needs to be addressed, not just nuking 5α-reductase with Dutasteride. Scalp Testosterone will still slowly chip away at your hair, regardless if DHT is there or not. In addition, Finasteride is insufficient to completely eliminate scalp DHT, which also needs to be taken into account and addressed. When you inhibit 5α-reductase, that Testosterone that would have otherwise converted to DHT doesn't just disappear, it remains as the parent hormone, thus raising total Testosterone levels in the body. Dutasteride doesn't just randomly stop working one day, Testosterone and other endogenous androgens are still eating away at your hair, just at a much slower pace than DHT would. The only way to prevent other androgens from binding to androgen receptors and miniaturizing hair follicles is by competing with them for androgen receptor binding. That's where the therapeutic promise of topical anti-androgens, anti-androgens in general, selective androgen receptor modulators, and other similar compounds that bind to androgen receptors can come into play and provide a compounding level of protection when needed, or as a form of monotherapy on their own if sufficient. If you only inhibit 5α-reductase with Finasteride, not only will you have residual amounts of DHT, but you will also have a spike in scalp Testosterone that is totally unaccounted for. Unfortunately, you can't just partially inhibit 5α-reductase and expect complete protection for life unless you have very mild hair loss to begin with. Permanent prevention can only be achieved by addressing the androgen receptor itself. For some individuals, Finasteride monotherapy will be sufficient to stave off hair loss for a couple decades, but that residual DHT and spike in Testosterone will continue to chip away and eventually win in the end. For some with aggressive hair loss, Finasteride monotherapy isn't even sufficient in the short-term. At the end of the day, regardless of how aggressive your hair loss is, prevention is mediated via the androgen receptor. Other treatment options may be implemented that interact with different downstream mechanisms in the cascade of events that lead to hair loss, but they will unlikely prove sufficient to completely mitigate androgenic alopecia on their own, and will be best utilized as an adjunct treatment to achieve a compounding level of protection with other compounds. Which Is Better For Hair Loss Prevention? RU58841 and Finasteride work via different mechanisms of action. They shouldn't be pitted against one another as neither are likely to prove sufficient to completely prevent hair loss on their own. DHT has a much higher binding affinity than RU58841, but Testosterone doesn't. Those with very aggressive hair loss would likely need to use a massive dose of RU58841 to compete with all of their scalp DHT and Testosterone. On the other hand, Finasteride can significantly decrease DHT levels, but causes a subsequent spike in scalp Testosterone that goes completely unaccounted for that will still work in tandem with the residual DHT to miniaturize hair follicles. A more complete level of protection would be achieved by using both Finasteride and RU58841, not one or the other. Finasteride will significantly reduce the amount of scalp DHT, and leave a hormonal environment that RU58841 is more capable of dealing with. RU58841's binding affinity is at least as high as Testosterone, so if most of the DHT is cleared out of the way, RU58841 only has to compete with Testosterone and a much lower amount of DHT. Expecting RU58841 to out-compete all endogenous DHT and Testosterone without any assistance when its binding affinity is several times lower than DHT is a strategy that would likely only work long-term for someone with mild hair loss. The dose and frequency of administration relative to the half-life needs to be kept in mind as well. There's a dose-dependent response with all drugs, including anti-androgens. Just because a 5% RU58841 solution applied once per day proves sufficient for one guy, that doesn't mean that dosage will be sufficient for you too. Hair loss is basically just a giant chess match where the most efficacious treatments will either knock out the opponent (decrease endogenous androgen levels), or occupy a more advantageous position on the chess board (binding to androgen receptors). The more chess pieces you have, the better your chance of winning against the finite number of opponent chess pieces. This is why certain anti-androgens with very poor binding affinity can still be effective in a clinical setting. An anti-androgen dosed very aggressively will eventually overpower Testosterone and DHT just by sheer volume (e.g. Bicalutamide). The same applies for RU58841, assuming it gets absorbed, which will boil down to scalp skin porosity, vehicle, and so on. If you opted for CB-03-01 instead of RU58841, the same concept would apply, it would just need to be dosed even more aggressively until sufficient AR binding is achieved. For those prone to side effects, that strategy may be the better alternative with CB-03-01 rather than RU58841 as it seems that the metabolites of CB-03-01 may be better tolerated at higher dosages than those of RU58841. The binding affinity of CB-03-01 is much lower than RU58841 though and it is very cost prohibitive, so for the time being, that strategy is likely not viable for most. Where To Buy RU58841 Most RU58841 sources do not third party test their products, nor do they have any satisfactory level of quality control whatsoever. I strongly advise that before you buy RU58841 from a company online you thoroughly evaluate their track record, their third party test results, and how they are marketing their products in general. These are the only companies I currently use for my own personal research: (Greater Than 99% Purity: FTIR, HPLC, GC-MS, LC-MS & NMR Tested) Science.bio – 10% off coupon code “DC10” Chemyo – 10% off coupon code “DC10” Anageninc - 5% off coupon code "DC5"

Dave Clark of The Dave Clark Five gives Kyle Meredith a call to talk about the band's new compilation, All The Hits, which finds the legendary group's songs on vinyl for the first time in decades, remixed and remastered at Abbey Road Studios. On that topic, Clark dispels the long-running notion that there was ever a rivalry between the DC5 and The Beatles. We also hear about taking on their record label to release "Because" as a single, the Coast To Coast LP (fun fact: "Any Way You Want It" was the final song the Ramones ever played live), and the untold story behind "Universal Love", which was brought out of the vaults to close out this collection. For information regarding your data privacy, visit acast.com/privacy

This episode is sponsored by https://dungeonnotebook.com/ makers of the Tomb of Delving. Use Discount code DC5 at check out to get $5 off your purchase of this awesome character and adventure record book! On this weeks episode we build a dungeon with the help of polls answered by listeners like you! Find out what won and see how we go about building a dungeon on the fly. Spoilers; it goes a lot better than we thought it would - well, at least we think so! After that we read some listener mail and answer a question about players changing characters. If you would like your question read on the show send them in to DifficultyClass@gmail.com!

Windmill, trap door. What could go wrong? Will things ever be the same? Join us on our epic DnD…..well, maybe not so epic…..but, pretty cool adventure, as our family takes on the roles of our adventurers. Sisters Amara and Shayna, Brother Josiah, Friends Brian, Lisha and Papa David all gather to play the role-playing game … Continue reading "Time to go Spelunking! -DC5"

The BEATLES opened the door to America for many "British Invasion" acts. One of them was the Dave Clark Five ~ We'll hear a 30-minute DC5 hits segment, plus cool demos, alternate takes, & live tunes from the Fabulous Four ~AND, a segment from an exclusive interview that Steve Ludwig did on his Classic Pop Culture Show with MAY PANG, John's confidante and girlfriend in the mid-1970's...

In an episode first aired on February 4, 2008 "Come To The Sunshine" #35 spotlights the Dave Clark Five, as host Andrew Sandoval presents more than two hours of their finest recordings direct from original vinyl pressings. Hear the stomping Tottenham sound of Lenny, Mike, Rick, Dennis and Dave via their self-penned and produced eleven or so albums - None of which are available on CD - but some of which have recently appeared in part on iTunes. The DC5 are one of the hardest rocking bands on record from the original British invasion and this program highlights seldom heard nuggets from their catalog: album only tracks, rare singles and items never issued in the US, their brief forays into psychedelia - the best of the best and then some. You will get a true picture of what this band was all about. A full playlist is available at: http://www.cometothesunshine.com/id52.html

Rare Interview from one of the great 60s entrepreneurs