Podcasts about erosive

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Best podcasts about erosive

Latest podcast episodes about erosive

Rio Bravo qWeek
Episode 174: GERD in Adults

Rio Bravo qWeek

Play Episode Listen Later Jul 19, 2024 19:07


Episode 174: GERD in AdultsCommon and atypical symptoms are presented. Pathophysiology, diagnosis, and management are discussed. H. pylori's role is discussed during this episode. Written by Jacquelyn Garcia MS4 Ross University School of Medicine. Comments by Hector Arreaza, MD.You are listening to Rio Bravo qWeek Podcast, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California, a UCLA-affiliated program sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. This podcast was created for educational purposes only. Visit your primary care provider for additional medical advice.Definitions: Gastroesophageal reflux (GER): occasional backflow of stomach acid into the esophagus. It's a common physiological process that happens to many people, especially after meals. Occurs less than twice a week. Associated with mild and temporary symptoms such as heartburn or regurgitation. Gastroesophageal reflux disease (GERD): a chronic and more severe form of GER. It occurs when acid reflux happens frequently, typically more than twice a week, and/or causes esophageal injury/complications. -Non-erosive reflux disease (NERD)= GER without evidence of esophageal injury on endoscopy. -Erosive reflux disease (ERD)= GER with evidence of esophageal injury on endoscopy.AFP Journal, January 2024: “Nonerosive GERD does not increase the likelihood of esophageal cancer. However, erosive GERD is associated with a doubled, but still low, risk of developing cancer, with the likelihood increasing over time.”Pathophysiology:The main pathophysiology behind GERD is lower esophageal sphincter (LES) dysfunction which can occur due to the following:-LES Pressure: The LES is a muscular ring at the junction of the esophagus and stomach. It normally maintains a high-pressure zone to prevent reflux. In GERD, the intragastric pressure is higher than the pressure created by the LES. The tone of the LES can be reduced by caffeine, nitroglycerin, and scleroderma. -Transient LES Relaxations (TLESRs): These are normal relaxations of the LES that occur independently of swallowing. In GERD, these relaxations are more frequent or prolonged, allowing acid to reflux into the esophagus.-Anatomic abnormalities: A hiatal hernia occurs when a portion of the stomach protrudes through the diaphragm into the chest cavity. This disrupts the normal anatomy of the gastroesophageal junction, reducing the pressure barrier and promoting reflux.Epidemiology: It affects 10-20% of adults in Western cultures and less than 5% in Asia. Prevalence in the US ranges from 18.1% to 27.8% with a slightly higher rate in men. Risk factors: -Obesity, pregnancy, scleroderma, hiatal hernia; smoking, caffeine, alcohol, stress, fatty/fried/spicy foods. Spicy foods can be a challenge in some cultures (e.g. Mexican and Indian.) Sometimes, patients may ask for “something” to stop GERD but all they may need is dietary modification. -Medications: -aspirin, ibuprofen, clindamycin, tetracycline, bisphosphonates (irritate the esophagus and cause heartburn pain similar to GERD) -anticholinergics, TCA's, CCB's, ACEi, statins, benzodiazepines, theophylline, opioids, progesterone (increase acid reflux and worsen GERD)Clinical features: Typical symptoms: -heartburn (burning retrosternal pain) -regurgitation (acidic stomach contents)Atypical symptoms: -chest pain (can mimic angina pectoris, squeezing/burning substernal, radiates to back/neck/jaw/arm) -water brash (hypersalivation)-globus sensation (lump in throat)-nausea -belching-bloating Alarm features in GERD: -dysphagia-odynophagia (pain with swallowing)-new onset of dyspepsia in ≥60yo -weight loss-GI bleeding-vomiting-anemia Diagnosis: -There is no gold standard test -Patient with typical symptoms: diagnosis can be based on clinical symptoms alone -Patient with atypical symptoms: these symptoms can be seen in GERD but are not sufficient for diagnosis of GERD in the absence of typical symptoms. Need to rule out other disorders before associating the symptoms with GERD. (ex: chest pain r/o other causes such as MI with ECG) -Patient with alarm features: refer to GI for upper GI endoscopy. Complications: -Esophagitis: Erosive reflux disease (ERD) = GER with evidence of esophageal distal injury on endoscopy; in untreated GERD 30% have esophagitis. -Iron deficiency anemia: due to mucosal ulcerations -> chronic bleeding.-Esophageal stricture: narrowing near GE junction, solid food dysphagia.-Barrett Esophagus: intestinal metaplasia of esophagus due to chronic GERD (stratified squamous epithelium replaced by columnar epithelium)-Risk factors: GERD for 5-10 years, >50yo, males, obesity, Caucasian, Tobacco use, family history                 -Predisposes to esophageal adenocarcinoma Role of H. pylori.Sometimes we tend to think that H. pylori is the cause of GERD. “H. pylori infection appears to protect the esophagus from gastroesophageal reflux disease, Barrett's esophagus, dysplasia in Barrett's esophagus, and esophageal adenocarcinoma, perhaps by causing chronic gastritis that interferes with acid production.”It is unclear whether long-term use of PPIs heightens the risk of atrophic gastritis in patients with H. pylori. Consequently, routine screening for H. pylori infection and empiric eradication of H. pylori are NOT advised for patients with GERD. However, if H. pylori is diagnosed in the setting of GERD, eradication of H. pylori has been associated with an improvement of symptoms in patients with antral-predominant gastritis. Treatment: Two categories: Mild/intermittent symptoms (

Keeping Current CME
What's New in the Treatment of Gastroesophageal Reflux Disease and Erosive Esophagitis: Spring Meeting Updates

Keeping Current CME

Play Episode Listen Later Jun 11, 2024 72:31


Hear from 3 experts as they discuss the latest clinical knowledge on the management of gastroesophageal reflux disease (GERD) and erosive esophagitis. Credit available for this activity expires: 6/11/25 Earn Credit / Learning Objectives & Disclosures: https://www.medscape.org/viewarticle/1001184?ecd=bdc_podcast_libsyn_mscpedu

The Dictionary
#E136 (eristic to erosive)

The Dictionary

Play Episode Listen Later Mar 11, 2024 39:08


I read from eristic to erosive.     The erlenmeyer flask is good for swirling. https://en.wikipedia.org/wiki/Erlenmeyer_flask     Wow, there are a lot of love/lust deities, including Eros, Cupid, and many I've never heard of.  https://en.wikipedia.org/wiki/Eros https://en.wikipedia.org/wiki/List_of_love_and_lust_deities     I still don't totally understand Eros (as opposed to the Death Drive), but it's an interesting concept, I guess, and seems to be about creating life or creation in general. Hmmm.  https://en.wikipedia.org/wiki/Eros_(concept)#Freud https://en.wikipedia.org/wiki/Death_drive     The word of the episode is "erogenous".     Theme music from Tom Maslowski https://zestysol.com/     Merchandising! https://www.teepublic.com/user/spejampar     "The Dictionary - Letter A" on YouTube   "The Dictionary - Letter B" on YouTube   "The Dictionary - Letter C" on YouTube   "The Dictionary - Letter D" on YouTube   "The Dictionary - Letter E" on YouTube     Featured in a Top 10 Dictionary Podcasts list! https://blog.feedspot.com/dictionary_podcasts/     Backwards Talking on YouTube: https://www.youtube.com/playlist?list=PLmIujMwEDbgZUexyR90jaTEEVmAYcCzuq     https://linktr.ee/spejampar dictionarypod@gmail.com https://www.facebook.com/thedictionarypod/ https://www.threads.net/@dictionarypod https://twitter.com/dictionarypod https://www.instagram.com/dictionarypod/ https://www.patreon.com/spejampar https://www.tiktok.com/@spejampar 917-727-5757

Evidence-Based GI: An ACG Publication and Podcast
Non-Erosive GERD Does Not Lead to an Increased Risk of Esophageal Adenocarcinoma

Evidence-Based GI: An ACG Publication and Podcast

Play Episode Listen Later Feb 21, 2024 14:39


NB Hot Topics Podcast
S5 E1: GP motivations; morning after pill & NSAIDs; cancer risk with non-erosive GORD

NB Hot Topics Podcast

Play Episode Listen Later Sep 15, 2023 21:38 Transcription Available


Welcome to Season 5 of the Hot Topics podcast from NB Medical with Dr Neal Tucker. Despite celebrating our 25th birthday (don't forget to check out our NB Plus birthday special here) the world of medical news and research never stops. In this episode we look at research in the BJGP about the motivations behind being a GP, whether adding NSAIDs may improve efficacy of emergency contraception, and whether we should be worried about cancer in patients with reflux.www.nbmedical.comReferencesBJGP Mapping GP MotivationsLancet Levonorgestrel + piroxicam for ECBMJ Non-erosive reflux and oesophageal cancer riskwww.nbmedical.com/podcast

Radiology Student
Radiopaedia Cases

Radiology Student

Play Episode Listen Later Dec 30, 2022 1:23


Erosive arthritis

radiopaedia erosive
Evidence Based Hair
Season 3, Episode 6 (Hydroxychloroquine and Oral Minoxidil for LPP, Gout in AKN, Shingles and EPDS, Renbok phenomenon, ACD in FFA/LPP)

Evidence Based Hair

Play Episode Listen Later Nov 21, 2022 65:03


LEARNING OBJECTIVES By the end of the podcast, the listener should be able to Discuss the benefits of HCQ in LPP Outline allergens that may be relevant in LPP/FFA Discuss the benefits of LDOM in LPP Describe the Renbok phenomenon and how it relates to FFA Outline the potential triggers for EPDS Describe the relationship between AKN and gout     EFFICACY OF HYDROXYCHLOROQUINE IN LICHEN PLANOPILARIS   Vastarella M et al (starts at 6:08). Efficacy and safety of hydroxychloroquine for the management of lichen planopilaris in a real-life setting. Ital J Dermatol Venerol. 2022 Jun;157(3):296-297.   Chiang C et al (starts at 14:17). Hydroxychloroquine and lichen planopilaris: efficacy and introduction of Lichen Planopilaris Activity Index scoring system. J Am Acad Dermatol. 2010 Mar;62(3):387-92.   Dhonncha EN et al (starts at 16:05). The role of hydroxychloroquine in the treatment of lichen planopilaris: A retrospective case series and review. Dermatol Ther. 2017 May;30(3).       ALLERGIC CONTACT DERMATITIS IN LICHEN PLANOPILARIS AND FRONTAL FIBROSING ALOPECIA   Prasad et al (starts at 18:38). Patch testing and contact allergen avoidance in patients with lichen planopilaris and/or frontal fibrosing alopecia: A cohort study J Am Acad Dermatol Aug 2020   Shtaynberger B et al (starts at 22:51). The Prevalence of Type IV Hypersensitivity in Patients With Lichen Planopilaris and Frontal Fibrosing Alopecia. Dermatitis. 2022 Oct 17.       USE OF ORAL MINOXIDIL IN LICHEN PLANOPILARIS   Vano-Galvan S et al (starts at 36:42). Oral minoxidil improves background hair thickness in lichen planopilaris. J Am Acad Dermatol 2021 Jun;84(6):1684-1686.     Giuseppe Gallo et al (starts at 37:45). Low-dose oral minoxidil in female patients with lichen planopilaris: Real-life experience. J Eur Acad Dermatol Venereol. 2022 Aug 16         RENBOK PHENOMENON IN FRONTAL FIBROSING ALOPECIA   Sławińska M et al (starts at 42:29). Frontal fibrosing alopecia sparing a dermal melanocytic nevus: a report of two cases of Renbök phenomenon. J Eur Acad Dermatol Venereol. 2022 Dec;36(12):e1042-e1043.   EROSIVE PUSTULAR DERMATOSIS AND SHINGLES   Salah NB et al (starts at 45:21). Erosive pustular dermatosis of the scalp in the COVID-19 era. J Cosmet Dermatol. 2022 Nov 14.   Akpandak I et al (starts at 50:55). Assessment of Herpes Zoster Risk Among Recipients of COVID-19 Vaccine. JAMA Netw Open 2022 Nov 1;5(11):e2242240.     RISK OF GOUT IN ACNE KELOIDALIS Eran Shavit et al (starts at 53:40). The burden of gout in acne keloidalis nuchae-Insights from a population-based study. J Cosmet Dermatol. 2022 Nov 8.

Evidence-Based GI: An ACG Publication and Podcast
Vonoprazan, a Potassium-Channel Acid Blocker, is Superior to Lansoprazole for Managing Erosive Esophagitis

Evidence-Based GI: An ACG Publication and Podcast

Play Episode Listen Later Nov 11, 2022 13:20


Evidence Based Hair
Evidence Based Hair - Season 1, Episode 2 (Telogen Effluvium, Trichotillomania, Tinea Capitis)

Evidence Based Hair

Play Episode Listen Later Feb 14, 2022 32:44


STUDIES REFERENCED IN THIS EPISODE   TELOGEN EFFLUVIUM - HAIR LOSS FOLLOWING COVID 19 STUDY 1 (starts at 3:09 ): Lopez-Leon S et al. More than 50 Long-term effects of COVID-19: a systematic review and meta-analysis. medRxiv. 2021 Jan 30;2021.01.27.21250617. STUDY 2 (starts at 4:47): Muller-Ramos P et al. Post-COVID-19 hair loss: prevalence and associated factors among 5,891 patients. Int J Dermatol 2022 Jan 26. STUDY 3 (starts at 10:32 ): Fernandez-de-Las-Penas et al. Female Sex Is a Risk Factor Associated with Long-Term Post-COVID Related-Symptoms but Not with COVID-19 Symptoms: The LONG-COVID-EXP-CM Multicenter Study. J Clin Med. 2022 Jan 14;11(2):413.   TELOGEN EFFLUVIUM IN CHILDREN STUDY 4 (starts at 12:45 ): Thomas et al.  Single Centre Retrospective Review ofNutritional Deficiencies Associated With Telogen Effluvium in the Paediatric Population in Canada. J Cut Med Surg Jan 2022 (online)     TRICHOTILLOMANIA  STUDY 5 (starts at 18:44) : Moattari et al. Adverse psychocutaneous effects of prescription stimulant use and abuse: A systematic review. J Dtsch Dermatol Ges. 2022 Jan;20(1):7-15. STUDY 6: (starts at 23:12); Vaccaro et al. Erosive pustular dermatosis of the scalp as local complication of trichotillomania. J Cosmet Dermatol. 2022 Jan 8. 2022 Jan 8     TINEA CAPITIS STUDY 7 (starts at 27:51): Friedland et al. Epidemiologic features and risk of scarring in pediatric patients with kerion celsi. Pediatr Dermatol. 2022 Jan 13. doi: 10.1111/pde.14916. Online ahead of print.  

Dermasphere - The Dermatology Podcast
63. BASCULE syndrome – Does dupi cause enthesitis? – SJS sequelae: Physical and psychological – Erosive pustular dermatosis of the scalp: Treatments – A scoring system for hand-foot-mouth-butt disease

Dermasphere - The Dermatology Podcast

Play Episode Listen Later Oct 4, 2021 65:49


BASCULE syndrome – Does dupi cause enthesitis? – SJS sequelae: Physical and psychological – Erosive pustular dermatosis of the scalp: Treatments – A scoring system for hand-foot-mouth-butt disease – In the Cage with Carlos: Insulin microneedling Luke's unboxing video: https://youtu.be/Dn65cjd-k2Y http://www.dermaspherepodcast.com/ Check out Luke and Michelle's *other* podcast: https://healthcare.utah.edu/dermatology/skincast/ Luke and Michelle report no conflicts of interest.

La stanza di Adil
S02E11 - Media e violenza sulle donne - Giulia Siviero

La stanza di Adil

Play Episode Listen Later Nov 23, 2020 31:55


Cimiteri dei feti e criminalizzazione dell'aborto, femminicidi, #tuttimaschi, Erosive, revenge porn e ruolo dei media... Conversazione con la giornalista Giulia Siviero.

Io, Viola.
La barriera.

Io, Viola.

Play Episode Listen Later Sep 26, 2020 18:36


Oggi, dopo un po', vi racconto cosa significa per me vivere a Barriera di Milano e concedermi la libertà di tornare di notte ed uscire in pigiama (non sembra, lo so, ma le due cose sono collegate).Link del festival Erosive : https://video.repubblica.it/cronaca/verona-michela-murgia-al-controfestival-della-bellezza-integrale/367421/367969

TG Zero
Podcast del 18/09/2020 - Daria Bignardi - Michela Murgia

TG Zero

Play Episode Listen Later Sep 18, 2020 138:01


Prima ora: - Liceo Socrate di Roma: "Niente minigonne a scuola, sennò ai prof gli cade l'occhio". Messaggi audio con i commenti degli ascoltatori. - Daria Bignardi ci presenta il suo nuovo programma, in onda da lunedì su Radio Capital. Seconda ora: - Omicidio di Willy Monteiro, aggiornamenti sul caso dei fratelli Bianchi, indagati da anni e mai arrestati. - Casa, chi compra vuole aree verdi. Crescono le richieste nelle periferie. - Bezos e la cricca dei multimiliardari: quelli che con la pandemia sono diventati ancora più ricchi. - RadioTraffic: la viabilità con Mita Fermi. - Intervista a Michela Murgia per parlare di “Erosive”, evento che si terrà in Piazza Bra a Verona, organizzato dalle ragazze di "Non una di meno", in risposta al Festival della Bellezza, dove sono stati invitati a parlare solo uomini. Scrittrici, artiste e intellettuali italiane parleranno di consenso, bruttezza, miti della bellezza ed eros. Terza ora: - In collegamento con Ettore Livini, parliamo di recovery fund e chiusura delle borse. - Comizi di chiusura della campagna elettorale per le regionali: al telefono, Francesca Schianchi de La Stampa.

OUTSPOKEN
OUTSPOKEN – Ep. 62 – Robin S.

OUTSPOKEN

Play Episode Listen Later Sep 6, 2019 72:11


Erosive culture, tribalism, evolving toward what works, the human exception, Ishmael, triggers and patterns, and much more...

UFC (UFC Sermons)
Erosive Doctrines

UFC (UFC Sermons)

Play Episode Listen Later Aug 12, 2019


Pastor Brett takes a break from the book of Mark to teach about erosive doctrines.

doctrines erosive
Dentist Brain Candy
EP161: Misdiagnosis of a Palatal Mass, OSA and Carotid Calcifications, dental implants in erosive lichen planus

Dentist Brain Candy

Play Episode Listen Later Jan 18, 2019 21:08


In this episode, I discuss the misdiagnosis of a swelling on the roof of the mouth that turned out to be cancer. This was misdiagnosed twice and can have serious implications for patients. In addition, we talked about the incidental radiographic finding with a panorex showing calcifications in the Carotid artery and its association with obstructive sleep apnea heart attacks and strokes. We also discuss using dental implants to help a patient with severe erosive lichen planus. Lichen planus can be a painful mucosal condition making Dentures very difficult or impossible to wear. Dental implants offers the opportunity to elevate the appliance off of the mucosa making impossible to wear Prosthetics without pain.

MinMon Podcast
MinMon Podcast #43 by Erosive

MinMon Podcast

Play Episode Listen Later Mar 4, 2018 136:33


Artist: Erosive https://soundcloud.com/erosive Interview & Download: www.minmon.de/minmon-podcast-43-by-erosive/ Label: Einstürzende Altbauten Stil: Techno/trippich Born: Krankenhaus On air since: Dezember 2012 Living: Potsdam Playtime: ??? Setup: Macbook Pro + Denon MC6000 MK2 Favoriten: Shifted, Regis, Developer Drink: Viel/Long Island Icetee Superpower: Pöbeln??? Support us @ www.facebook.com/MinMonKollektiv PODCAST Feed: www.minmon.de/category/podcast/feed/ iTunes: itunes.apple.com/de/podcast/minmo…ktiv/id694851128 SoundCloud: soundcloud.com/minmon_kollektiv/sets/minmon-podcast

regis erosive
MinMon Podcast
MinMon Podcast #43 by Erosive

MinMon Podcast

Play Episode Listen Later Mar 3, 2018


Mit dem MinMon Podcast Nummer 43 schlagen wir bzw. unser Gast etwas härtere Töne an. Techno – arrangiert und zusammengefügt von Erosive, einen durch seine regelmäßig stattfindenden Partyreihe „Einstützende Altbauten“ bekannten DJ aus der Hausbesetzer Szene. Erosive hat uns ein fettes zwei Stunden Set zusammen gemischt, welches den ein oder anderen sicher Erinnerungen an durchtanzte... Auch in Farbe und Bunt auf MinMon Podcast #43 by Erosive

Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 09/19
Surgical management of oral squamous cell carcinoma infiltrating mandible

Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 09/19

Play Episode Listen Later Dec 8, 2008


Progression of recent trends in mandible-preserving operations for the management of oral squamous cell carcinomas that infiltrate the mandible is rapid and accompanying studies give invaluable information concerning behavioral understanding of oral squamous cell carcinoma within the mandible. However, a large amount of sound osseous tissue is removed as part of partial mandibulectomy, because it is difficult to gain direct sight into the medullary portion and as a result of fear for residual tumor in this inaccessible space. Thus, needless defects are not seldom. For that reason, there still exists a strong demand for an operating protocol regarding precise surgical clearance which fulfills the surgeons' desire to be more conservative. Twenty-one with evidence of intraosseous tumor spread of 82 resected mandibles were radiologically and histologically reexamined to compare discrepancies among clinical, radiologic and histologic entities of oral squamous cell carcinoma infiltration. Size and location of primary tumor were dominant correlating factors of oral squamous cell carcinoma infiltration into the mandible and were statistically significant (p < 0.05). Larger tumors are more likely to infiltrate the mandible. Gingiva and retromolar trigone were the prevalent locations which facilitated tumor infiltration. Direct contact of the tumor on the attached mucosa usually provides portal of entry of the tumor through the cortex into the medullary space. Periodontal space in the dentate mandible is another possible portal of entry. Erosive-type infiltration is mostly seen in the shallower depth in early phase of infiltration and then followed by invasive type in the deeper portion of mandible. Infiltrating tumors usually do not exceed the limit of the primary on the mucosa, but it becomes unpredictable when inferior alveolar nerve related spread is once initiated. Five to 10 mm of surgical clearance is applicable to any surgical interventions regarding mandible infiltrating oral squamous cell carcinoma. However, thorough pre- and intra-operative attention should be put on the nerve related spread, extended resection of mandible is inevitable when nerve involvement is evident. A combination of orthopantomogram, computerized tomography and Tc-99m skeletal scintigraphy provide a good assessment of the tumor infiltration in the mandible. Distance measurement in orthopantomogram is reliable in localizing the tumor and in planning the surgical margin. An operating scheme based on the biologic behavior of oral squamous cell carcinoma within the mandible is devised as a result of this study.

Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 05/19
Minimale nicht-erosive endoskopische Läsionen in der Diagnostik der Endoskopie-negativen Refluxkrankheit des Ösophagus

Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 05/19

Play Episode Listen Later Feb 16, 2006


Die Diagnose der nicht-erosiven Refluxkrankheit der Speiseröhre war bislang eine Ausschlussdiagnose und basierte nicht auf endoskopischen Befunden. Die neueste und derzeit für wissenschaftliche Studien geforderte Klassifikation der Refluxösophagitis ist die 1994 vorgestellte Los Angeles Klassifikation. Bei der Erarbeitung dieser neuen Klassifikation wurden auch minimale reflux-assoziierte nicht-erosive Veränderungen des distalen Ösophagus evaluiert, aber aufgrund der hohen Interobserver-Variabilität nicht in die neue Klassifikation aufgenommen. In der vorliegenden Arbeit wird, im Licht einer während 10 Jahren deutlich verbesserten Videoendoskopie, der Frage der endoskopischen Diagnose von minimalen nicht-erosiven reflux-assoziierten Veränderungen des distalen Ösophagus erneut nachgegangen. In einem Zentrum wurden von einem erfahrenen Untersucher (> 3000 Gastroskopien) konsekutiv erwachsene Patienten im Alter von > 18 Jahren und < 80 Jahren mit reflux-verdächtigen Symptomen untersucht. Die Endoskopien wurden mit der neuesten Generation von Pentax Video-Gastroskopen der Serie EG2970K durchgeführt. Die Dokumentation der minimalen nicht-erosiven Veränderungen an der Epithelgrenze erfolgte mit einem Sony Colour Video Printer UP-2300P. Anschliessend wurden 4 Quadrantenbiopsien an der Epithelgrenze durchgeführt, die Zylinderepithel, die Z-Linie und Plattenepithel möglichst in einem Partikel erfassen sollten. Die histologische Graduierung erfolgte entsprechend den in der Arbeit von Vieth et al. (Scand J Gastroenterol 2001; 36:1123) publizierten Kriterien der Arbeitsgruppe von Prof. Stolte. Als Positiv-Kontrollen wurden Patienten mit erosiver Refluxösophagitis untersucht. Anacide Patienten, entweder mit atrophischer Autoimmungastritis im Endstadium oder mit einem Zustand nach Gastrektomie wurden als Negativ-Kontrollen verwendet. Insgesamt wurden 235 Patienten untersucht. Davon hatten 41 eine endoskopisch ’normale’ Z-Linie (= Gruppe 1). 117 Patienten mit Refluxsymptomen hatten minimale nicht-erosive Veränderungen im Bereich der Z-Linie (= Gruppe 2) und 53 hatten eine erosive Refluxösophagitis im Stadium A oder B entsprechend der Los Angeles Klassifikation (= Gruppe 3). Als anacide Kontrollen wurde 11 Patienten mit atrophischer Autoimmungastritis untersucht (= Gruppe 4) und 13 mit einem Zustand nach Gastrektomie (= Gruppe 5). Die histologischen Veränderungen im z-linien nahen Plattenepithel wurden unter dem Begriff ’hyperregeneratorische Ösophagopathie’ zusammengefasst. Ihre semi-quantitative Bewertung in gering-, mittel- und hoch-gradig ergab einen Median von 1 (= gering-gradig) für Gruppe 1, von 1 für Gruppe 2, von 2 für Gruppe 3 und von 0 für Gruppe 4 und 0 für Gruppe 5. Die Unterschiede zwischen den Negativ-Kontrollen und den Gruppen 1 bis 3 waren signifikant auf dem Level p < 0,001. Ebenfalls waren die Unterschiede zwischen der Positiv-Kontrolle und den Gruppen 1 und 2 signifikant. Die Diagnose NERD wurde insgesamt bei 113 von 158 Patienten (72.5 %) richtig gestellt. Die vorliegende Untersuchung zeigt, dass mit Hilfe der neuesten Generation Videogastroskope endoskopisch minimale Veränderungen im Bereich der Z-Linie diagnostiziert werden können, die erlauben, die Diagnose NERD positiv zu stellen. Weitere Untersuchungen sind erforderlich, um die hier formulierten Kriterien zu bestätigen und zu etablieren.

Medizin - Open Access LMU - Teil 12/22
Kaposi's sarcoma in a patient with erythroblastopenia and thymoma: Reactivation after topical corticosteroids

Medizin - Open Access LMU - Teil 12/22

Play Episode Listen Later Jan 1, 1998


We report a 69-year-old female with erythroblastopenia and thymoma who developed lesions of Kaposi's sarcoma (KS) after thymectomy, 2 months after the initiation of therapy with methylprednisolone. Control of mucocutaneous KS lesions was obtained with radiotherapy, interferon alfa-2b and withdrawal of systemic immunosuppressive therapy. Erosive oral lichen planus appeared later, and after therapy with topical corticosteroids a new lesion of KS developed that regressed after withdrawal of topical corticosteroids. The detection of HHV-8 only in lesional skin supports the hypothesis that this virus can trigger the development of KS lesions.