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Want to share your feedback? Send us a message!Researchers from the Delaware Stuttering Project at the University of Delaware—Dr. Ho Ming Chow, Associate Professor and principal investigator, Sayan Nanda, Ph.D. student, and Dr. Nicole Guarino, research scientist—join host Sara MacIntyre, M.A., CCC-SLP, to discuss their recent article, "Atypical gut microbiota composition in a mouse model of developmental stuttering," published in Scientific Reports (Nature Portfolio). Building upon previous genetic and mouse model research by Dr. Dennis Drayna and colleagues at the NIH [previous podcast episode with Dr. Drayna linked below for background], their study explores the potential link between developmental stuttering and the gut-brain connection by examining gut microbiota differences in GNPTAB mouse models.In this episode, Dr. Chow, Sayan Nanda, and Dr. Guarino provide essential background context before walking through the study's development, methodology, and key findings. They discuss the potential role of the microbiome in other neurodevelopmental conditions, the challenges of translating mouse model research to human studies, and the exciting directions for future research this study has prompted.Article discussed:Nanda, S., Lamot, B., Guarino, N. et al. Atypical gut microbiota composition in a mouse model of developmental stuttering. Sci Rep 14, 23457 (2024). https://doi.org/10.1038/s41598-024-74766-xPrevious Stuttering Foundation Podcast episode referenced, 'Genetics and Stuttering with Dr. Dennis Drayna.'Delaware Stuttering Project WebpageDr. Ho Ming Chow, Associate Professor at the University of Delaware and a principal investigator for the Delaware Stuttering Project, received his Bachelor's and Master's Degrees in Engineering at the University of Hong Kong. After working as an engineer for a few years, he became interested in studying human cognition and went to Germany for his doctoral study. He obtained his Ph.D. in Cognitive Sciences with an emphasis on Cognitive Psychology at the University of Osnabrück. He completed his postdoctoral training at the National Institutes of Health. Before joining the University of Delaware in 2019, he was a research faculty at the University of Michigan and Nemours Children's Hospital, Delaware.Sayan Nanda received his Master of Science in Data Informatics from the University of Southern California and his Bachelor of Technology in Computer Science and Engineering from the Manipal Institute of Technology. Sayan is currently a Ph.D. student in the Communication Sciences and Disorders department at the University of Delaware. Sayan is primarily interested in stuttering research and the application of statistics and machine learning techniques in the same. His focus is on neuroimaging.Dr. Nicole Guarino is an adjunct faculty at the Department of Communication Sciences and Disorders, the University of Delaware. She received her PhD in Neuroscience from Thomas Jefferson University and her B.A. in Neuroscience from Franklin and Marshall College. She has been working in Dr. Chow's lab since 2022 and is interested in the neurobiological bases of stuttering.
SO DAMN INTENSE!! Higher Learning Full Reaction Watch Along: https://www.patreon.com/thereelrejects Visit https://huel.com/rejects to get 15% off your order The final film before Don't Be A Menace In South Central While Drinking Juice In The Hood! Higher Learning Reaction, Recap, Breakdown, Commentary, Analysis, & Spoiler Review! Greg Alba & Coy Jandreau take on Higher Learning, the 1995 drama directed by John Singleton (Boyz N the Hood, 2 Fast 2 Furious) that tackles themes of race, identity, privilege, and systemic injustice in the American college experience. The film follows three freshmen—Malik (Omar Epps), Kristen (Kristy Swanson), and Remy (Michael Rapaport)—as they navigate the pressures of higher education, racial tensions, and personal transformation at the fictional Columbus University. Some of the most intense and pivotal moments include Malik's struggle with his track scholarship and racial identity, Remy's descent into white supremacy under the influence of Cole Hauser's character, and the tragic climactic shooting scene that shakes the entire campus. Other powerful moments include Ice Cube's character Fudge dropping hard truths about systemic racism, Laurence Fishburne's powerful lectures as Professor Phipps, and the heartbreaking fates of several key characters that still resonate today. Omar Epps as Malik Williams (Love & Basketball, House), Kristy Swanson as Kristen Connor (Buffy the Vampire Slayer, The Phantom), Michael Rapaport as Remy (True Romance, Atypical), Ice Cube as Fudge (Friday, Barbershop), Jennifer Connelly as Taryn (A Beautiful Mind, Requiem for a Dream), Tyra Banks as Deja (Coyote Ugly, America's Next Top Model), Laurence Fishburne as Professor Phipps (The Matrix, John Wick 2), Cole Hauser as Scott Moss (Yellowstone, 2 Fast 2 Furious), Regina King as Monet (Watchmen, If Beale Street Could Talk), and Busta Rhymes as Dreads (Halloween: Resurrection, Shaft). If you're a fan of John Singleton's socially conscious films, be sure to check out Boyz N the Hood (1991), Poetic Justice (1993), Baby Boy (2001), and Four Brothers (2005). Follow Coy Jandreau: Tik Tok: https://www.tiktok.com/@coyjandreau?l... Instagram: https://www.instagram.com/coyjandreau/?hl=en Twitter: https://twitter.com/CoyJandreau YouTube: https://www.youtube.com/channel/UCwYH2szDTuU9ImFZ9gBRH8w Intense Suspense by Audionautix is licensed under a Creative Commons Attribution 4.0 license. https://creativecommons.org/licenses/... Support The Channel By Getting Some REEL REJECTS Apparel! https://www.rejectnationshop.com/ Follow Us On Socials: Instagram: https://www.instagram.com/reelrejects/ Tik-Tok: https://www.tiktok.com/@reelrejects?lang=en Twitter: https://x.com/reelrejects Facebook: https://www.facebook.com/TheReelRejects/ Music Used In Ad: Hat the Jazz by Twin Musicom is licensed under a Creative Commons Attribution 4.0 license. https://creativecommons.org/licenses/by/4.0/ Happy Alley by Kevin MacLeod is licensed under a Creative Commons Attribution 4.0 license. https://creativecommons.org/licenses/... POWERED BY @GFUEL Visit https://gfuel.ly/3wD5Ygo and use code REJECTNATION for 20% off select tubs!! Head Editor: https://www.instagram.com/praperhq/?hl=en Co-Editor: Greg Alba Co-Editor: John Humphrey Music In Video: Airport Lounge - Disco Ultralounge by Kevin MacLeod is licensed under a Creative Commons Attribution 4.0 license. https://creativecommons.org/licenses/by/4.0/ Ask Us A QUESTION On CAMEO: https://www.cameo.com/thereelrejects Follow TheReelRejects On FACEBOOK, TWITTER, & INSTAGRAM: FB: https://www.facebook.com/TheReelRejects/ INSTAGRAM: https://www.instagram.com/reelrejects/ TWITTER: https://twitter.com/thereelrejects Follow GREG ON INSTAGRAM & TWITTER: INSTAGRAM: https://www.instagram.com/thegregalba/ TWITTER: https://twitter.com/thegregalba Learn more about your ad choices. Visit megaphone.fm/adchoices
Sorry folks, this episode is audio only, due to a technical fault uploading the video to Spotify. If you really want to see a video version, you can on YouTube at https://youtu.be/TJBNLRnTFcQIn this episode of Fly to Freedom, I'm addressing a topic that is often misunderstood, invalidated, and overlooked—atypical anorexia.If you've ever been told, “You don't look like you have an eating disorder” or felt like you don't deserve help because you don't fit the stereotype of anorexia, this episode is for you.Atypical anorexia is just as severe and life-threatening as anorexia nervosa, yet those who experience it often struggle in silence. I break down the science, misconceptions, and emotional impact of atypical anorexia and share why eating disorders should never be measured by weight alone.You'll learn:
Dr. Wilner would love your feedback! Click here to send a text! Thanks!Many thanks to Ronnie Laughlin, breast cancer survivor and author of “An Atypical Journey: Facing Breast Cancer Alone in the Middle East with God and My Tribe.” She also wrote the companion guide, “My Appointment Notebook,” to help people navigate the health care system when challenged with a breast cancer diagnosis. During our 30-minute conversation, we discussed how Ronnie handled the diagnosis of breast cancer, which she received while living alone in Saudi Arabia in the midst of the COVID-19 lockdown. She toughed it out during her chemotherapy, employing the determination and resilience that made her a Division 1 basketball player years ago. Her competitive nature and resolve were buttressed by strong Catholic Faith. Ronnie believes that her life experiences prior to her breast cancer diagnosis were God's “perfect preparation” that endowed her with the necessary skills to successfully navigate her illness. Ronnie explained that she wrote her books to help other people with breast cancer better understand how it affects their bodies and provide strategies to succeed with treatment. Ronnie's advice to those affected by breast cancer or other life threatening illness? “Keep moving forward and keep a positive attitude.” You can find Ronnie Laughlin's books on Amazon. For more information, check out her website: ronnielaughlin.comAnd social media:Instagram: @ronnielaughlinFacebook: V.ronnielaughlin.comauthorPlease click "Fanmail" and share your feedback!If you enjoy an episode, please share with friends and colleagues. "The Art of Medicine with Dr. Andrew Wilner" is now available on Alexa! Just say, "Play podcast The Art of Medicine with Dr. Andrew Wilner!" To never miss a program, subscribe at www.andrewwilner.com. You'll learn about new episodes and other interesting programs I host on Medscape.com, ReachMD.com, and RadioMD.com. Please rate and review each episode. To contact Dr. Wilner or to join the mailing list: www.andrewwilner.com To support this program: https://www.patreon.com/andrewwilner Finally, this production has been made possible in part by support from “The Art of Medicine's” wonderful sponsor, Locumstory.com, a resource where providers can get real, unbiased answers about locum tenens. If you are interested in locum tenens, or considering a new full-time position, please go to Locumstory.com. Or paste this link into your browser: ...
Swanner and Judd talk about: Drag Race; Traitors; Beast Games; Next in Fashion; Atypical; The Big Sleep; All the Sad Young Men; and more! Left Click To Listen, Right Click Here To Download
Synopsis: In this special episode of Biotech 2050, Host Alok Tayi, CEO and Co-Founder of VibeBio, delves into the world of neurodivergent entrepreneurship and impact investing with guest Chad Belinsky, founder of AtypicalPath.org. Chad shares his inspiring journey from running a transformative B2B materials company to establishing Atypical Path—a nonprofit dedicated to supporting neurodiverse individuals, fostering mentorship, and creating impact-driven investment opportunities. Together, they explore the unique perspectives neurodivergent individuals bring to innovation, the importance of self-awareness, and how capital can drive meaningful societal change. A must-listen for those interested in mission-oriented investment, entrepreneurship, and the untapped potential of neurodivergent talent. Biography: “Dumb” dyslexic, awkward aspie kid, empowered by love & tech, transformed himself and a bootstrapped family material science B2B into a 20 year overnight success with PE platform exit. Now stewarding the proceeds & sharing forward learnings through developing AtypicalPath.org , an entrepreneurial nonprofit community where accomplished neuro-atypical earnest entrepreneurs inspire each other to compound social & economic good, while sharing forward opportunity for the next generation to thrive, through shared wisdom, contacts, grants & impact investment.
OCD, or Obsessive Compulsive Disorder, is a debilitating condition that involves intrusive thoughts and time-consuming, repetitive behaviors. It impacts 80 million worldwide, 2-4% of the US population or 1 in 100 people here in the US.It can be difficult to overstate the suffering caused by OCD, not only for those with this condition but also for their family members. In addition to the distress caused by the obsessional thoughts and compulsions, there can be shame and loss - loss of more meaningful, purposeful, or pleasant thoughts and behaviors. and loss of time connecting with others or engaging in purposeful or enjoyable activities.Other conditions associated with obsessive-compulsive disorder include:* Body dysmorphic disorder* Skin picking* Trichotillomania (hair pulling)* Hoarding* Hypochondria* Olfactory reference syndrome (an irrational feeling or belief that one emits a foul smell and often attempts to remove the odor).It´s not unusual for someone with OCD to have other conditions, such as:* Other forms of anxiety* Depression* ADHD* Autism spectrum disorder* Eating disorders* TourettesResearch suggests that having OCD raises one´s vulnerability to developing dementia. Many other brain conditions, however, also appear to increase this vulnerability similarly.Treatment ChallengesOCD is particularly challenging to treat. Of those with OCD, 60% do not respond to typical therapies (often medication in combination with psychotherapy involving gradual exposure to that which is being avoided). Typical medications include:* SSRI´s (Selective Serotonin Reuptake Inhibitors) -e.g., sertraline, fluoxetine, fluvoxamine, citalopram, paroxetine* Tricyclic antidepressant - clomipramine* SNRI - (Serotonin and Norepinephrine Reuptake Inhibitor) - venlafaxine* Atypical antipsychotic medications are sometimes addedMedication is combined with CBT (Cognitive Behavioral Therapy), which involves exposure and response prevention, or CBT is used alone.As you can see, most medication approaches aim to increase serotonin activity. Serotonin, however, is just one of the neurotransmitters involved. What has become increasingly clear from the research is that OCD involves abnormal activity at the NMDA receptor - a glutamate receptor.NMDA & GlutamateThe NMDA receptor is found throughout the brain. Glutamate, the primary excitatory neurotransmitter in the central nervous system, binds to the NMDA receptor. NMDA and glutamate are involved in synaptic plasticity (creating neuronal connections), learning, memory, and motor function.The synapse is the space between communicating neurons. Presynaptic neurons release glutamate, which binds to the NMDA receptor on postsynaptic neurons. This results in a cascade of signaling events that lead to “neuronal excitation.” The problem arises when this receptor has too much (or too little) activity. In the case of OCD, there is too much activity.Implications* Dysregulation at the NMDA receptor appears to play a role in OCD, depression, PTSD, schizophrenia, bipolar disorder, and substance use disorders.* Weak memory extinction can result from high activity at the NMDA receptor. While memory is a good thing, we can have problems with too much memory - or rather, problems putting our memories aside. This can look like thoughts getting stuck, for example:* Intrusive thoughts in OCD* Flashbacks in PTSD* Delusions in psychotic disorders* Cravings in addiction.* Neurodegenerative disorders, such as Alzheimer's, Parkinson's, and ALS, have also been linked to NMDA receptor malfunction.Methylation & NMDAThose who are undermethylated, especially those with OCD or addictions, have high activity at the NMDA receptor. To remind you, undermethylation is a biochemical process with many functions, including the breakdown of histamine, support of detoxification, and support of serotonin activity. When someone is undermethylated, they can tend to have allergies (from high histamine), be perfectionistic, competitive, strong-willed, have obsessive-compulsive tendencies, be ritualistic, have dietary inflexibility, and have high accomplishment or have family members with high accomplishment. Undermethylation can contribute to the low serotonin activity seen in OCD. Simply addressing undermethylation, like merely addressing serotonin, will only bring partial benefit. To address undermethylation, those of us trained by the Walsh Research Institute, use SAMe and/or methionine, B12, B6, magnesium, and antioxidants. We address this before starting methylation treatment for those with high homocysteine. But how can we also decrease activity at the NMDA receptor?Blocking NMDA & Normalizing Glutamate ActivityEsketamine or Ketamine, which has been getting much attention in recent years, can impact the brain in various ways; however, its primary mechanism is as an NMDA blocker or antagonist. For some, it can serve as a rapid-acting and highly effective antidepressant. It can also decrease OCD symptoms. Other NMDA-blocking drugs include memantine and dextromethorphan (combined with bupropion). Lamotrigine can decrease glutamate release and has been used as an adjunct medication for OCD.Nutrients, however, play an important role in the NMDA receptor. NAC or N-acetyl cysteine is a precursor to glutathione and, thus, an antioxidant. It is also anti-inflammatory and a binder for a particular toxin made by candida and mold. But, it is also a potent NMDA antagonist (decreases activity at NMDA) and has been shown to reduce obsessions and compulsions of OCD. It has also been studied in alcoholism, opiate addiction, cocaine abuse, gambling disorder, shopping disorder, cigarette addiction, and trichotillomania. It has been used by itself and as an adjunct to medication therapy. NAC has become part of the Walsh undermethylation nutrient protocols for those with OCD and/or addiction.Zinc also plays an important role in regulating functioning at the NMDA receptor. The Walsh Research Institute found that 90% of those with brain symptoms had relatively low zinc. Dosing of zinc is determined after testing plasma zinc levels using a narrow range (the Walsh/Pheiffer range differs from typical lab ranges). Zinc is checked in conjunction with copper. Zinc has been found to improve treatment response in those with OCD treated with SSRIs. Zinc can be depleted because of very high oxidative stress and/or high pyrroles, which also cause low B6. Because B6 is needed to make serotonin, pyrroles are also important to address if elevated.Inositol is a nutrient involved in the serotonin and glutamate signaling systems. It, too, is beneficial for OCD symptoms; however, it can require very high doses.The challenge of research, as you can see, is that these approaches are all looked at in isolation, as opposed to, for example, addressing undermethylation, optimizing zinc, decreasing activity at the NMDA and addressing sources of oxidative stress.Candida & MoldAside from undermethylation, low serotonin activity, and high activity at the NMDA receptor, those with OCD appear to have high oxidative stress, as is the case with most brain-related conditions. One of the more common sources of oxidative stress I see in my practice is candida overgrowth in the GI tract, which often follows antibiotic exposure and /or mold toxicity due to water damage causing seen or unseen toxic mold. Because mold and candida (yeast) thrive on sugar and a high-carb diet, symptoms can fluctuate with sugar or carb intake. How might candida and mold intersect with the NMDA receptor? Mold and yeast can contribute to high histamine states. Histamine can increase activity at the NMDA receptor. EstrogenFor women and teen girls that I see with OCD, there is often a fluctuation in their OCD symptoms with their cycle. Typically, their symptoms worsen during the times of the month when estrogen is the highest. This may be because estrogen can increase activity at the NMDA receptor.PANDAS & PANSWhen a child has an abrupt onset of OCD symptoms, PANDAS and PANS should be considered.* PANDAS = Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections* PANS = Pediatric Acute-Onset Neuropsychiatric SyndromePANDAS and PANS are autoimmune conditions, meaning the immune system is acting on the body, in this case, a part of the brain called the basal ganglia, that involves an acute onset of OCD symptoms. Other symptoms can include restricted eating, mood symptoms, regression in academic or social skills, and motor tics. While triggers are often viral, bacterial (strep in the case of PANDAS), candida,or other microbial source, what is underlying the dysregulated immune response to such microbes, in my experience, is mold toxicity. SummaryBecause OCD can be difficult to treat, my hope in sharing this information is to raise awareness that effective OCD treatments can require a multifaceted approach that includes:* addressing methylation (and high pyrroles if present) to improve serotonin activity* decreasing activity at the NMDA receptor* by optimizing zinc* using supplements or medication* addressing sources of inflammation and high histamine* address sources of oxidative stress - trauma, stress, toxins, inflammation If you find this information helpful and would like to help me get this out into the world, please consider sharing:As always, I welcome your comments, questions, and experience.Until next time,CourtneyP.S. To learn more about non-patient consultations, treatment, and monthly mentorship groups, please visit my website at:CourtneySnyderMD.comMedical Disclaimer:This newsletter and podcast episode is for educational purposes and not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment for yourself or others, including but not limited to patients you are treating (if you are a practitioner). Consult your physician for any medical issues that you may be having. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit courtneysnydermd.substack.com/subscribe
On this episode of It's a Spectrum, Rian sits down with Lucky Leftie (@LuckyLeftie) to talk about their journey to an autism diagnosis, growing up undiagnosed and the complexities of self-discovery. They also dive into the struggles of autistic representation in media, from Atypical to The Good Doctor, and the challenges of navigating social expectations as an autistic person. Plus, a hilarious discussion on semantic shifting, TikTok discourse, and why people still argue about Asperger's. Follow Lucky Leftie: https://www.youtube.com/@thefourthsaluki https://www.tiktok.com/@luckyleftie Support the podcast: Patreon - https://patreon.com/reydarpod?utm_medium=unknown&utm_source=join_link&utm_campaign=creatorshare_creator&utm_content=copyLink Merch - https://www.etsy.com/shop/RiansMerch Legacy Teas and Spices: https://legacyteasandspices.com Use code UP20 Follow Us: Podcast pages - https://linktr.ee/reydarpod https://www.instagram.com/reydarpodcast?igsh=NTc4MTIwNjQ2YQ%3D%3D&utm_source=qr Rian Reyes - https://linktr.ee/rianreyes Josh the Producer - https://www.instagram.com/imjoshuabenjamin?igsh=NTc4MTIwNjQ2YQ==
Swanner and Judd talk about: Drag Race; Traitors; Wow Report; Beast Games; Next in Fashion; Atypical; Ari Shaffir: American Sweetheart; C Duncan: It's Only a Love Song; and more! Left Click To Listen, Right Click Here To Download
It was another day of volatility in crypto, and traders, analysts, and market commentators began to sound alike, saying that this bull cycle no longer resembles bulls of the past. But why? After we look at that, it's on to some major US political moves that will affect crypto, from SEC “relief” to crypto regulation proposals from lawmakers. Finally, we'll look at ZachXBT's latest investigation that suggests Coinbase users are being scammed out of $300 million per year!Further reading:‘Atypical' Bitcoin bull market can extend beyond March 2025 — ResearchCrypto market has become ‘very confusing,' losing all logic — TradersSEC is evaluating ‘retroactive relief' for past coin offeringsUS lawmakers will propose crypto regulation by Nov — Anthony ScaramucciCoinbase accused of neglecting security, costing users up to $300M annuallyRise'n'Crypto is brought to you by Cointelegraph and is hosted and produced by Robert Baggs. You can follow Robert on Twitter and LinkedIn. Cointelegraph's Twitter: @CointelegraphCointelegraph's website: cointelegraph.comThe views, thoughts and opinions expressed in this podcast are its participants' alone and do not necessarily reflect or represent the views and opinions of Cointelegraph. This podcast (and any related content) is for entertainment purposes only and does not constitute financial advice, nor should it be taken as such. Everyone must do their own research and make their own decisions. The podcast's participants may or may not own any of the assets mentioned.
Hello Listeners, For a machine generated transcript of this episode, click here. Follow Patrick at his Substack Newsletter here, and learn more about his practice or schedule a reading by using this link. *** Free Saboteur Self-Assessment from Positive Intelligence Link to schedule Free Saboteur Discovery Session 1:1 call with Cristy *** We would love to hear your thoughts or questions on this episode via SpeakPipe: https://www.speakpipe.com/SomaticWisdomLoveNotes To show your gratitude for this show, you can make a one-time gift to support Somatic Wisdom with this link. To become a Sustaining Honor Roll contributor to help us keep bringing you conversations and content that support Your Somatic Wisdom please use this link. Thank you! Your generosity is greatly appreciated! *** Music credit: https://www.melodyloops.com/composers/dpmusic/ Cover art credit: https://www.natalyakolosowsky.com/ Cover template creation by Briana Knight Sagucio
Hello ! Aujourd'hui je suis de retours pour vous faire mon épisode bilan de l'année 2024, oui je suis un peu en retard ^^ Corée: Bon: Pyramide game, Hierarchy, Blood free, Gyeongseong Creatures S2, Fragil, Love in the big city Best: Flexxcop, Marry my husband, Atypical family, Lovely runner, A shop for killers, Love for love sake, Miss night and day, The auditors, The trunk The plot, What comes after love, The light shop, Revolver, Possessed love Chine: Bons: Regeneration, Double love Très Bons: Derailment, The legend of Shenli, The Spirerealm, War of faith, Her story, Blooming si ça continue comme ça Japonais: Chastity high, Kesenai, Shapes of love Thai: Cherry magic, The sign, Spare me your mercy
"Send me a text message and let me know what you think of the First-Time Leaders Accelerated℠ Podcast."New Year's resolutions should not only consider improving existing processes but also have an atypical consideration of whether those processes should continue to be performed at all.Are you prepared to lead people? Find OutIf you need a Leadership Speaker or you need help with Leader Development and/or Culture Improvement, visit tdspi.com and Click on Meet Me.I look forward to our "get to know each other" conversation.Treat people like they make a difference and they will.Support the showEnroll in the First-Time Leader Development ProgramTimothy Dean Smith Leadership Speaker, Coach, Podcast Hostwww.tdspi.comtds@tdspi.com(607) 221-6191Thank you for listening.
Cinema To The Letter encourages you to - even in the worst of times - always look on the bright side of life! To close out the Criterion season, Thomas, the non-messiah Bryan and very special guest Jael Peralta discuss the out-of-print spine entry that still counts as part of the collection Monty Python's Life of Brian! Together, our trio will answer the crucial questions. Who is their favorite Monty Python member? Why must Criterion selections go out of print? Which zany comedies should become part of the Criterion Collection? Well, grab your gourd or shoe (whichever your denomination prefers) and settle in to listen so you can find out! Join our Patreon for $1 for monthly bonus episodes and the chance to vote for new podcasts at patreon.com/cinema2letter! Follow us @cinema2letter on socials! Artwork by Michelle Kyle! Music by Burial Grid! We're a proud member of the TalkFilmSociety podcast network!
Cinema To The Letter encourages you to - even in the worst of times - always look on the bright side of life! To close out the Criterion season, Thomas, the non-Messiah Bryan and very special guest Jael Peralta discuss the out-of-print spine entry that still counts as part of the collection Monty Python's Life of Brian! Together, our trio will answer the crucial questions. Who is their favorite Monty Python member? Why must Criterion selections go out of print? Which zany comedies should become part of the Criterion Collection? Well, grab your gourd or shoe (whichever your denomination prefers) and settle in to listen so you can find out! Join our Patreon for $1 for monthly bonus episodes and the chance to vote for new podcasts at patreon.com/cinema2letter! Follow us @cinema2letter on socials! Artwork by Michelle Kyle! Music by Burial Grid! We're a proud member of the TalkFilmSociety podcast network!
Patrick, a Buffalo Bills fan, became a North Dakota State University Team Maker after Phil Hansen was drafted by the Bills and Patrick became curious about Phil's college team. He began following the Bison and has even made a trip to Frisco.
This DermSurgery Digest bonus content aptly named “At the Microscope” shares the latest research and techniques in dermatopathology. In this episode, we will review Atypical Fibroxanthoma and Pleomorphic Dermal Sarcoma. Contributors to this podcast include Naomi Lawrence, MD, Dermatologic Surgery Digital Content Editor; Ashley Elsensohn, MD, MPH, DermSurgery Digest at the Microscope co-host; Christine Ahn, MD; Jeff Gardner, MD; Marina K. Ibraheim, MD; and Michael P. Lee, MD.Articles Reviewed: Agaimy A. The many faces of Atypical fibroxanthoma. Semin Diagn Pathol. 2023 Jul;40(4):306-312. doi: 10.1053/j.semdp.2023.06.001. Epub 2023 Jun 23. PMID: 37438163. Link: https://pubmed.ncbi.nlm.nih.gov/37438163/ Ørholt M, Abebe K, Aaberg F, Rasmussen LE, Daugaard S, Loya AC, Herly M, Vester-Glowinski PV. Immunohistochemical Characteristics of Atypical Fibroxanthoma and Pleomorphic Dermal Sarcoma: A Systematic Review and Meta-Analysis. Am J Dermatopathol. 2022 Dec 1;44(12):913-920. doi: 10.1097/DAD.0000000000002305. PMID: 36395448. Link: https://pubmed.ncbi.nlm.nih.gov/36395448/van Midden D, Flucke UE, Amir AL, Bonenkamp JJ, Lubeek SFK, Blokx WAM. Atypical fibroxanthoma and pleomorphic dermal sarcoma: Is superficial infiltration in subcutaneous tissue acceptable in AFX? Ann Diagn Pathol. 2022 Jun;58:151915. doi: 10.1016/j.anndiagpath.2022.151915. Epub 2022 Feb 10. PMID: 35276548. Link: https://pubmed.ncbi.nlm.nih.gov/35276548/Anders IM, Schimmelpfennig C, Wiedemann K, Löffler D, Kämpf C, Blumert C, Reiche K, Kunz M, Anderegg U, Simon JC, Ziemer M. Atypical fibroxanthoma and pleomorphic dermal sarcoma - gene expression analysis compared with undifferentiated cutaneous squamous cell carcinoma. J Dtsch Dermatol Ges. 2023 May;21(5):482-491. doi: 10.1111/ddg.15006. Epub 2023 Apr 10. PMID: 37035902. Link: https://pubmed.ncbi.nlm.nih.gov/37035902/ Listeners are encouraged to submit questions for podcast hosts to answer in a later episode. To submit your questions, email communicationstaff@asds.net.
The often challenging diagnosis of neuromuscular junction (NMJ) disorders can be explained by suspicious red flags for the key differential diagnoses (mimics) and atypical presentations (chameleons). In the latest Editor's Choice paper podcast, PN's podcast editor Dr. Amy Ross Russell interviews Dr Stephen Reddel and Dr Shadi El-Wahsh, both from the Concord Hospital, New South Wales, Australia, and the authors of Neuromuscular junction disorders: mimics and chameleons. Please subscribe to the Practical Neurology podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3vVPClm) or Spotify (https://spoti.fi/4baxjsQ). We'd love to hear your feedback on social media - @PracticalNeurol. Production and editing by Letícia Amorim, Amy Ross Russell, and Brian O'Toole. Thank you for listening.
Get out of here Ryan Reynolds! Ow! Hey, knock it off. I will throw Blake lively at you! You're going to throw my ex wife at me? Or is that his current wife? I thought he was married to Anna Farris? Maybe I had them mixed up. Or—did I get the order wrong? No, literally I thought it was the same girl. Basically. No, no—they're very different… on the inside. That's a low blow. It's okay, if I aim below the belt, that may be exactly at eye level. I will throw Anna Farris at you! Blake lively sounded better. Goddammit. Let's just shoot both takes and see which flows better. Okay. I will throw Black Lively at you! You're going to throw my ex wife at me? She is very small and aerodynamic. You don't think I know that? Gross! You're gross! Ow! Stop throwing things at me! The next thing is— No ex-wiving! This is high stakes. Damn, do I technically have to get all three of them to sign off on this? I don't know—the legal technicalities. Why not, you're a lawyer? I am. —?! Yes. varying degrees of sincerity Do you want to play with sharks? Hm–what? What's that? Do you want a bite to eat? I'm flying, flying Gotta learn how to lie, kid I'm dying, i'm dying you know I've got my eye on you Everything I need is in this Shower scene I dare you I do care, dont you know, I don't want to see you there no more I'm nowhere, nowhere to be found Look where I found you In the dark, sir Yes, you are off Awful, Swimming with the sharks and stuff Just another poet Just another broken heart a song or something With my palms up And my psalms are omens All my palams are Swimming with the sharks, mom All my thoughts are Swimming with the sharks She's couvered in turquoise, aquamarine; her choices and voice are all ive seen of this Suffering somewhere and surfing the Thing I need Keeping me peopleing “People gon people, though” Go, GO! This is bad. This looks bad. No. Green is good. (Finds One Dollar) Oh look! Money! Try this guy now! Uh, uh ! no way! I'm way past that! What! You are! Yeah! [BLEEP] That was an accident. F[BLEEP] Damn, man. How long have you been like this (He takes a drink of whiskey and shrugs, grimacing) Forever. “ TheJohn Oliver effect". Ambivalence - Apparently (what I woke up in my head with this morning Most of my dreams were just horrible night mares and waking in cold sweats To ovens still heartbroken What inthe world, i wonder But i don't have to, lover Mother, brother, friend another world just to worry over Haven't you heard? It's a world of absurdatites, Listen, Being assertive is part of promotion It passes, this Ambevalice or however you spell it I'll come back to correct it in my Google documents But that's not the words To this song? I don't want no more money I just want to run off into the sunset With a surfboard And only return here Once I can afford to love The shops on madison avenue Not in some person's pocket, But because I'm so astonishing to someone I actually bought it And what if IF is where I found him, actually If this and If that The infinite man in the hat But i just brought the rabbit out Rabbit, I Have a couple habits planted On this planet He's a madman, you know As I am Yes, I am I am a madman you now NAM DAMA MI You know me, I was 16 16 16, 17 Patiently waiting to make it To break into industry I should have all of the world in my hands On my shoulders, you know Was the Grammy, and Emmy I asked uncle Tony, come over He warned me for Oscar, “You don't really know that man” Show me, I wanted to wonder into the silver screen It really was me, Before shows became talkies The Golden Ones Oh The Golden Globes Peabody Please God, A job, to afford a new body I want to be Model Hot Model One Teslas And Teslas, The best Exstacy Ive ever tasted Besides those quad stacks; Super Marios, yo I was playing the game CAuse he Triple dog dared me A Dog, I was so lost in love With my own stockholm syndrom I was an apocalypse, but Happy life, happy wife Happy knife in my back Cause I can't love a man Besides All in my head Blow me off of this earth with that cannon, would ya– Would you blow me bubblgum bubbles out of your Bazooka I was just wondering what kind of nuts you were Probably cumsluts, bananas, a And master producers Composers, And actors, Establishment Haven't been black Since i found out its bad to be Back in the rap industry, however At my bathtub briefing They could see us coming From a mile away I just keep running Runing my day, yep Was the thing I created I hated her Then, I Maiden Voyaged this Bon, voyage, bitch You've been on the Titanic since I decided to sink it What you think? All of the women and children fit? That's just a fairy tale I don't need this, till i get to Israel And I dn't think he's real, but I'm real good at Hurting myself HUrting myself Hurting myself To hell with it, just make me a man Or just Make me a mandate I passed all this under the table My management Man is Damaged Why am I haunting you, Ali Cause, trust me It's up from her Up from here Up from Up there Now youre scaring me I've been suicide for days and contemplating Not suicidal But suicide it'self Its not my idol or an icon, Not a role model, impossible ImPOSTTIBLE MEANWHRiLE: CAT (Crying) –Moo! HI, Cat. I'm so stuck in this nonsense of “Social order” and I'm supposed to So stuck in this existence Of Diseveled Hellcat Welcome Patrick Stuck under the arches of McDonalds With a Picket line Made of picket fences and dissinstrists Diminishing wits And [The Festival Project™] https://en.m.wikipedia.org/wiki/Primetime_Emmy_Awards https://en.m.wikipedia.org/wiki/Peabody_Awards https://en.m.wikipedia.org/wiki/Primetime_Emmy_Awards https://en.m.wikipedia.org/wiki/Time_100 https://en.m.wikipedia.org/wiki/Time_100 https://en.m.wikipedia.org/wiki/Christ%27s_College,_Cambridge https://en.m.wikipedia.org/wiki/Christ%27s_College,_Cambridge https://en.m.wikipedia.org/wiki/England https://en.m.wikipedia.org/wiki/England https://en.m.wikipedia.org/wiki/Stephen_Oliver_(composer) Do you smell–does anyone else smell eggs, right now? No, Patrick. Are you sure? Positive. KANDI Fuck, it's positive again. PATRICK Well, have another. (he take a long drag off of is cigarette, handing KANDI another pregnancy test.) KANDI How many do you want me to do? PATRICK All of them. KANDI is petite, about 5'0 to 5'3, Pacific Islander and/or Asian of darker complexion, with long raven hair, and wide chestnut brown eyes, between 20 and 25 years old. She is well dressed and feminine, however, with a somewhat staggering eloquence, sometimes quite crass, uneducated–but quick witted, often funny, and very, very beautiful. She is typically relaxed, however, has the tendency to panic as a natural reaction to PATRICK'S erratic gestures and mood swings; She acts as his primary comforter and companion,. You know, I actually can't see this show happening Who has seen it? Martians, or, maybe just– God, I guess. That's what you got out of that. I don't know, God! Atypical, this Conformity to confirmation Servitude and service Disconnected from astonishments Abolishing the altar Of the alter I'm so Sorry for this –Missed Connections He took the 4 I took the 6 Missed Connections I wasn't set up to talk that day He was though I did good enough For impressions Selective, this one Damages I'm sorry for this Missed Connections I'll never make it in this industry –Not with that attitude And not with that hat one It's something and somewhere between Honesty and Lost in the world Trying not to suffer for the plot of The literal Star Wars The literal definition of Punch me in the face and ruin my world I guess God wasn't watching On 4/40 Or was Very drunk, then WOAH. WHAT'S HAPPENED TO MY EYES. You're telepathic, I gathered, however Synthtic Under static cling and Establishments Multicamera facets And facinations with women Habits and inclinations, then Well, This is Synethetics, Fuck it. I L0VlE IT. IS THAT WHAT LOVE IS?! That's what love looks like In manhattan Hopped up on a One day fast Two You fucked up Three You fucked up Who loves him For punching me? Someone, Cause that brought you up a bit, Didn't it? Is it up or is it just endless death and a torture chamber At the chamber of commerce Without my kid? Then again… I don't envy this, at all Was just a dream, you know My dreams have all become Derilicts Fuck DIllon Francis (I should have, when I had the chance!) When was THIS? I like your outfit? I just have No other plans But just to Catch this JELLYFISH Capture this! (she laughed at the dancer) Phones, up, kids! I can't possibly be famous! Yesterday you said: FUCK THIS NIGGA Today it's JIMMY FALLON You know what. I'm okay with this. WHAT. I never said that. Okay, Jim. You can come down, now. That was a long day, you know Up in a harness Suspended But it wasn't that part The hardest Would only be Some caricature Of aperture The departure from Humanity as God CAuse you wound up in the Strung up Kite I hung up When i uncrossed all my crosses Then Just gave up on [The Festival Project ™ ] Talking to God about What the fuck is wrong with My sense of smell And my Hell is just Never ever being Trying not to talk to Cannot say this name if I was paid to But i fucking hate you JImmy Fallon https://youtube.com/shorts/_go5tL7Jw2w?si=Ffz6Y1eKU2_SugtG This, What happens When you're a rockstar spirit in the cost of sobriety And all you want is just A lover to What is that? Love, though? What is that? “The pollution in the ocean is the solution to your problem” –the aliens https://www.youtube.com/watch?v=ZSviZnbAv8M Now i fantasize about these guys, Knives in my backs, an iPod nano And buying a pager Wait till God makes good on my wages For these pages I just can't these days I just can't Flag Flag X The Germs Danny Elfman, Oingo Boingo Anthony was beautiful, Reminds me of my Johnny Boy I've been californiacated I've been mesmerized by Love and drugs And janes addiction Fornication, rock and roll Another genre, Mom is lost, you guys And momma won't come home The smiths Gangs of four Souzie sue? I don't want to know you like that, man I don't want to worry, on the backpage Didn't i just come back from the Blacklands? Back then, it was a Flatline It was a backstage fire It was a heart attack, That It was a heart attack that killed that man Watch your heart, but don't Whatever you do Watch this show {Enter The Multiverse} [The Festival Project] Hey . Hi, Johnny Depp. You can =come join our club, if you want. And what club is that? It's “Cribbage Club” We have hats Hats. On Yahtchs. The Old Men Sittiing around the table drinking What is that? It's mustard. Just– Really? Yes. 30 Rockefeller Plaza's studio 8H This is why I don't trust you! Don't trust me! You don't follow the code! There's a code! You wrote the code! Oh, that's–that sucks. Everything sucks. Everything sucks. Everything sucks, that's right. EVERYTHING SUCKS CAUSE OF YOU ADAM, YOU RUINED IT ADAM RUINS EVERYTHING RAYMOND, I LOVE YOU EVERYBODY LOVES RAYMOND CHRIS, I [CENCORED] HATE YOU. EVERYBODY HATES CHRIS EVERYTHING SUCKS CAUSE OF SUNNI BLU Or really just I HATE U good . keep hating then. i'mma go get my dick sucked By a supermodel At the supermarket, And then be a superhero And put that shit on an album, You know what? keep fuckin hating keep fuckin hating But you know what somebody's gonna LOVE it And that's why youre over here All fucked up Cause i love you But FUCK you No fuck U keep hating 111
The Psychology of Self-Injury: Exploring Self-Harm & Mental Health
In this episode, Ellie from the United Kingdom and National Health Service (NHS) shares her lived experience of atypical severe self-injury while participating in a psychiatric inpatient stay for an acute increase in severity of eating disorder symptoms. She discusses how she has used her experiences as a patient and recipient of mental healthcare in the UK to bring about systemic change, participate as a co-producer and research, and advocate for those with lived experience of nonsuicidal self-injury (NSSI) and self-harm. While participating in our interview while in inpatient care, we invite her live-in care provider (i.e., carer), Shami, to join our conversation and offer her own insights.Connect with Ellie on LinkedIn here and on Twitter/X @EllieWildbore or @elliewildbore.bsky.social. Visit her blog at https://balancingontheborderline.home.blog/. Here are two links to Ellie being interviewed about lived experience research and her work on YouTube with the Mental Elf: https://youtu.be/HezHKYrF7zM and https://youtu.be/IA91M6fGaQo. Read the pre-print of her article referenced in this episode available for free here. Learn more about Atypical Severe Self-Injury by listening to our episode with Dr. Barry Walsh on the topic from Season 1 here. Want to have a bigger role on the podcast?:Should you or someone you know be interviewed on the podcast? We want to know! Please fill out this Google doc form, and we will be in touch with more details if it's a good fit.Want to hear your question and have it answered on the podcast? Please send an audio clip of your question (60 seconds or less) to @DocWesters on Instagram or Twitter/X, or email us at thepsychologyofselfinjury@gmail.comWant to be involved in research? Send us a message at thepsychologyofselfinjury@gmail.com and we will see if we can match you to an active study.Want to interact with us through comments and polls? You can on Spotify!Follow Dr. Westers on Instagram and Twitter/X (@DocWesters). To join ISSS, visit itriples.org and follow ISSS on Facebook and Twitter/X (@ITripleS).The Psychology of Self-Injury podcast has been rated as one of the "10 Best Self Harm Podcasts" and "20 Best Clinical Psychology Podcasts" by Feedspot and one of the Top 100 Psychology Podcasts by Goodpods. It has also been featured in Audible's "Best Mental Health Podcasts to Defy Stigma and Begin to Heal." Goodpods Top 100 Parents Podcasts Listen now to The Psychology of Self-Injury: ExploringSelf-Harm & Mental Health podcast Goodpods Top 100 Research Podcasts Listen now to The Psychology of Self-Injury: ExploringSelf-Harm & Mental Health podcast
Pediatrics Now: Cases Updates and Discussions for the Busy Pediatric Practitioner
In this episode of Pediatrics Now, host Holly Wayment welcomes Dr. Tess Barton, an infectious disease expert at the University of Texas Health Science Center and University Health. Together, they explore the rising trend of atypical pneumonia, caused by mycoplasma, commonly known as "walking pneumonia." Dr. Barton shares insights into the clinical presentation of mycoplasma infections, emphasizing the importance of awareness among pediatricians. She discusses diagnostic challenges, testing options, and treatment considerations for atypical pneumonia, highlighting the current surge in cases. The conversation also addresses common questions from both practitioners and parents, including the contagious nature of walking pneumonia and strategies for managing symptoms. Additionally, the episode touches on the broader landscape of respiratory illnesses, the role of vaccines, and practical advice for managing fever and respiratory distress in children. This informative discussion is essential for pediatric practitioners navigating the complexities of respiratory infections this season. Don't miss the upcoming episode on managing pain in children, featuring expert advice from recent grand rounds. Stay tuned for more insights on Pediatrics Now.
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To end their ghost movie season and ring in Halloween, Cinema To The Letter is going truly Atypical. Thomas, Bryan and special guest Emily Slade of the Why This Film Podcast are breaking all the rules of cinema by covering the infamous feature length BBC TV special Ghostwatch! Together, our trio will answer the crucial questions. How did Ghostwatch get banned from British TV for decades while becoming a cult classic? What would the American equivalent of something this unique? Can a podcast itself become an unholy seance? Well, tune in "live" and listen to this episode to find out! Join our Patreon for $1 for monthly bonus episodes and the chance to vote for new podcasts at patreon.com/cinema2letter! Follow us @cinema2letter on the socials! Artwork by Michelle Kyle! Music by Burial Grid! We're a proud member of the TalkFilmSociety podcast network!
To end their ghost movie season and ring in Halloween, Cinema To The Letter is going truly Atypical. Thomas, Bryan and special guest Emily Slade of the Why This Film Podcast are breaking all the rules of cinema by covering the infamous feature length BBC TV special Ghostwatch! Together, our trio will answer the crucial questions. How did Ghostwatch get banned from British TV for decades while becoming a cult classic? What would the American equivalent of something this unique? Can a podcast itself become an unholy seance? Well, tune in "live" and listen to this episode to find out! Join our Patreon for $1 for monthly bonus episodes and the chance to vote for new podcasts at patreon.com/cinema2letter! Follow us @cinema2letter on the socials! Artwork by Michelle Kyle! Music by Burial Grid! We're a proud member of the TalkFilmSociety podcast network!
Mining Stock Daily hosts Tommy Thornton from Hedge Fund Telemetry to discuss the current state of the market, focusing on the bond market, inflation, the U.S. dollar, and gold. They analyze the recent pullback in major indices, the implications of rising bond yields, and the potential impact of inflation on equity prices. The discussion also touches on the strength of the U.S. dollar and its relationship with gold, concluding with insights on market sentiment and investment strategies.
In this episode, host Alyssa Watson, DVM, is joined by Tamara McArdle, DVM, DABVP (Canine & Feline Practice), to discuss her recent Clinician's Brief article, “Vaccinations in Atypical Veterinary Patients.” Dr. McArdle shares key considerations for assessing vaccination efficacy and risks, including patient health, immune response, and the impact of various medications and anesthesia. She also covers how to manage both common and uncommon vaccine reactions, as well as strategies for addressing client concerns about vaccination safety.Resources:https://www.cliniciansbrief.com/article/vaccine-immune-response-side-effectshttps://www.simparicatriodvm.com/Contact:podcast@instinct.vetWhere To Find Us:Website: CliniciansBrief.com/PodcastsYouTube: Youtube.com/@clinicians_briefFacebook: Facebook.com/CliniciansBriefLinkedIn: LinkedIn.com/showcase/CliniciansBrief/Instagram: @Clinicians.BriefX: @CliniciansBriefThe Team:Alyssa Watson, DVM - HostAlexis Ussery - Producer & Multimedia Specialist
Friend of the show, friend of mine, academic superstar, podcaster, author (Death by Comfort), speaker, researcher, periodic pugilist, ex-military officer, stoic, family man and deep thinker, Paul Taylor, is back at the TYP Central. Apart from delivering another fascinating chat, PT also drops a personal bombshell about his health (you'll have to take a listen) and subsequently, we chat about the very interesting way that he's chosen to deal with said issue. It's kind-of surprising but knowing Taylor, not surprising at all. Atypical is typical for him; if you know what I mean? Enjoy. *The title will make sense, once you listen. See omnystudio.com/listener for privacy information.
He's been on our screens making us laugh for years, most recently in Colin From Accounts, but in this chat Patrick Brammall unpacks one of his more meaty roles to date… Being a first time dad! Patty's path to parenthood is a little unique with him and his wife Harriet Dyer adopting a baby girl in 2021 (Harriet is also co-creator/co-star of Colin From Accounts). Patty talks us through this experience, how it's fundamentally changed him, his perspectives and priorities. And given his daughter was just 2 and a half when we recorded this, Patty is the first to admit that he really is still trying to figure this dadding thing out!! Patty is so honest about the ups and the downs, his hopes and fears, the sleep deprivation and the toll it's taking on his face, and how he is still coming to terms with the fact that his time will never be his own again (well, not for the next 15 years or so). Patty, like all of us, is attempting this parenting Rubik's cube on the fly, and sometimes it's working, and sometimes it's not!! And if that wasn't enough, we have a brief musical interlude from a neighbour. This episode has got it all! Huge thanks to Patty (and Harriet) for sharing this really personal story, and for carving time out of a pretty jammed schedule to chat with us. In Australia Seasons 1 and 2 of Colin From Accounts is on Binge - and it's really really great. If you have not seen it you really should watch it, like tonight. You can drop us a line anytime at howotherdadsdad.com - we love hearing from you guys. Thanks for listening! *Producer Note - Despite anything Hamish says to the contrary, all music contained within this episode is fully licensed for all necessary exploitation and distribution, including the music which the neighbour started playing through Hamish's Bluetooth speaker inadvertently. — Big thanks to our great friends at HERTZ, our exclusive sponsor for the whole of Season 3! Just like us, they are big fans of adventure and memory making and in a great deal for HODD listeners, if you need a rental car in Australia, head to hertz.com.au/hodd for 25% off the base rate. What a great deal! Ts&Cs apply. See website for details.See omnystudio.com/listener for privacy information.
Chad and his wife Kim were the former owners of Marco Rubber & Plastics, a o-ring and seals provider, which they turned into a high-tech supplier of industrial products. With tremendous access to products that they both had in their inventory and that their suppliers had in their inventory, they turned Marco Rubber into a marketplace platform for the industrial products industries they served (think of the way Kayak is to travel). You will hear Chad describe himself as neurodiverse. I described him with great love, as I describe both of us as…ADD, dyslexic misfits who would have a hard time working for anybody else. Chad dives into his process of building authenticity and earnestness through the awkwardness of being neurodiverse and coming into the business to help Dad and the family after his mom passed and his father became terminally ill. As in many of our client's journey's go, after 20 years Marco Rubber became an overnight success and had a capital gain transaction with a private equity firm where he and Kim continue to own a percentage of the company and have board seats while the company continues to grow. I think it's true that the company is now about three times the size that it was when they did a transaction about three years ago. Chad goes on to share about his world “post exit,” and how for him it was really an opportunity for rebirth and to articulate the beliefs that he developed over the years of building the business. He'll tell you about how he is gathering all of this knowledge and experience and creating opportunities for other neuroatypicals in his new, not-for-profit, what he calls www.atypicalpath.org (website still in development) I really hope you enjoy this incredibly dynamic interview with one of the most insightful EOMs you'll ever want to meet.
Dr. Günter Höglinger discusses new genetic findings and other exciting research surrounding PSP and other atypical parkinsonisms.
Amparo Casar, Círo Gómez o Lilly Téllez pueden ir a Atypical; un roto para un descosido: Mesa+AlláEnlace para apoyar vía Patreon:https://www.patreon.com/julioastilleroEnlace para hacer donaciones vía PayPal:https://www.paypal.me/julioastilleroCuenta para hacer transferencias a cuenta BBVA a nombre de Julio Hernández López: 1539408017CLABE: 012 320 01539408017 2Tienda:https://julioastillerotienda.com/ Te invitamos a que visites nuestro perfil en Patreon. Solo da clic aquí Hosted on Acast. See acast.com/privacy for more information.
In this week's episode we'll discuss a novel tripartite fusion drives treatment resistance in acute promyelocytic leukemia. In some patients with atypical APL, these novel retinoic acid receptor gene fusions result in truncation of the ligand binding domain of the retinoic acid receptor protein, resulting in non-responsiveness to treatment with all-trans retinoic acid. After that: managing immune thrombotic thrombocytopenia or iTTP without therapeutic plasma exchange, or TPE. Finally, hope for motherhood after allogeneic HCT.Featured Articles: Critical role of tripartite fusion and LBD truncation in certain RARA- and all RARG-related atypical APLManagement of immune thrombotic thrombocytopenic purpura without therapeutic plasma exchangeHope for motherhood: pregnancy after allogeneic hematopoietic cell transplantation (a national multicenter study)
Atypical anorexia nervosa (AAN) is a sub-diagnosis for patients who meet all the criteria for anorexia, except for being underweight. However, the term “atypical” is a glaring misnomer, as AAN affects up to 4.9% of people during their lifetime, whereas anorexia nervosa (AN) affects about 0.6%. Atypical anorexia became a subtype of other specified feeding and eating disorders (OSFED) in 2013, leading to many common misconceptions about the severity of the illness and its best treatment approach. In this episode, Dr. Cara Bohon, licensed clinical psychologist, Clinical Associate Professor, Department of Psychiatry and Behavioral Sciences, Stanford University, and Senior Vice President of Clinical Programs at Equip, will explore these diagnostic labels, assess the severity and treatment trajectory for patients with AAN compared to AN, and propose considerations for future diagnostic clarifications. Learning Objectives: Explain the differences (or lack thereof) between atypical anorexia nervosa (AAN) and anorexia nervosa Recognize the severity of AAN and the urgency for treatment Identify necessary components for treatments for AAN If you'd like to obtain continuing education as a psychologist, counselor, social worker, or therapist you can purchase a one-year subscription to Psych Hub's training center. Once signed up, you'll have access to earn CEs for this and every Therapy Cafe episode, plus access to our existing library of over 120 evidence-based practice continuing education courses created by expert clinicians. Go to psychhub.com/signup for more information. Learn more about Dr. Cara Bohon at https://www.linkedin.com/in/cara-bohon/ To learn more about Equip, visit http://equip.health/psychhub.
In part two of this two-part series, Drs. Jeff Ratliff, Michiko K. Bruno, and Lawrence Golbe discuss essential advice for general neurologists who suspect a patient might have an atypical disorder. Show reference: https://www.neurology.org/doi/full/10.1212/CPJ.0000000000200345
In part one of this two-part series, Drs. Jeff Ratliff, Michiko K. Bruno, and Lawrence Golbe discuss practical tips for recognizing when a patient's response to levodopa may indicate the need for an alternate diagnosis. Show reference: https://www.neurology.org/doi/full/10.1212/CPJ.0000000000200345
Dr. Jeff Ratliff talks with Drs. Michiko K. Bruno and Lawrence Golbe about a practical diagnostic algorithm for atypical parkinsonian disorders, emphasizing the importance of recognizing these conditions in clinical practice. Read the related article in Neurology: Clinical Practice. Disclosures can be found at Neurology.org.
Listen in as Nas discusses one of her favorite dramas of the year, The Atypical Family, with Ori and Hil! . . . Timestamps: K-Catch Up (01:01), The Rundown (12:05), First Impressions (12:42), Character Discussion (15:32), Notable Scenes (33:46), Hot Takes (01:16:16), Ratings and Rankings (01:18:38), Lessons Learned (01:19:40)
It's time for Girls Gone Hallmark's Hallmark+ review! Megan and Wendy dive into their thoughts on the second episode of The Chicken Sisters. They wrap up their discussion on the show's large ensemble cast, debate whether it's been fully "Hallmarkified," and explore just how much Sabrina is influencing Kitchen Clash. Email us your review at girlsgonehallmark@gmail.com or let's talk about it in the Girls Gone Hallmark Facebook Group! We Need Your 5-STAR Ratings and Reviews Spotify Podcast listeners: Spotify allows listeners to rate podcast episodes. Once you listen to a podcast for at least 30 seconds, you get the option to rate it between one and five stars. Return to the podcast's main page and tap the star icon. Then, tap submit. About The Chicken Sisters, Episode 2 - (Hallmark+, 2024) James Kot plays Frank Jr. - James has 31 acting credits which most recently include: Virgin River, Christmas on Cherry Lane, and When Calls the Heart. Jake Foy plays Kenneth. We first met Jake when he played Tuff McMurray on Ride. We're glad to have him back in a Hallmark series we're loving. Other roles in his 22 credits include: Designated Survivor, A Little Daytime Drama, Wilderness and Allegiance. Cardi Wong plays Gen - Cardi has 54 acting credits including his role on Tipline Mysteries: Dial 1 for Murder. His other Hallmark appearances include Flip That Romance, One Winter Proposal, My Best Friend's Bouquet, and the Crossword Mysteries series. Ektor Rivera plays Sergio - This is Ektor's 13th credit and his third appearance on Hallmark having previously appeared in Groundswell and Sugar Plum Twist. He also had a role in the thriller StartUp streaming on Crackle. Arkie Kandola plays cameraman Gordon. He is currently appearing in the Hulu series How to Die Alone. His 25 credits also include Our Big Punjabi Family, Upload, and the one-season wonder Megan wishes everyone would watch: No Tomorrow. Samer Salem plays Jay - Samer has 33 total acting credits, mostly trending toward grittier fare. He did appear on one episode of Hudson and Rex and has also appeared on Yellowjackets, The Handmaid's Tale, and The Good Doctor Andrew J Hampton plays Kenneth's husband Patrick. Andrews's first full-length feature was in Grease Live! Where he had an uncredited role. Since then he has appeared in Atypical, The Flash, So Help Me Todd, Blockbuster, Dream Moms and Upload for a total of 15 acting credits. Kimmy Gatewood and Annie Mebane return as director and writer respectively. Catch Up on Our Reviews of The Chicken Sisters Family is Family, episode 1 Our Thoughts on The Chicken Sisters Girls Gone Hallmark: Chicken Sisters Episode 2 Recap and Review Here's a quick rundown of the detailed recap and review of Episode 2, "I Walked the Line" (or "We're on the Same Team, Y'all") from the Hallmark series, Chicken Sisters. that we run in our episode of Girls one Hallmark. Key Events of Episode 2 The Franny's Girl vs. Mimi's Girl Narrative The episode begins highlighting the traditional rivalry between Franny's and Mimi's. We see how being a Franny's girl signifies being on the "right" side while being a Mimi's girl denotes the opposite. This rivalry not only introduces tension but offers depth to the backstories of characters like Nancy and Gus. Nancy and Frank Jr.'s Dynamic Nancy struggles with her identity after the loss of her husband, Frank. It's heartbreaking to witness how Frank Jr. treats her, mirroring behaviors that might have been modeled by his father. The episode delves deeper into Nancy's past, showing her sacrifices and longing for validation from her son. The Sabrina and Amanda Facade Sabrina, a master manipulator, manipulates Amanda into revealing sensitive information about Mae's past working at Donkey's. This not only fuels the drama but also underscores Sabrina's sneaky nature, making her a complex yet enjoyable character to watch. Media Training Drama
If you or someone you know is struggling with an eating disorder, help is available. Reach out here. At least 30 million Americans have an eating disorder, but only 1 in 10 people gets the treatment they need. Why? Kylee and Zoë debunk common myths about eating disorders, from who they affect to how they're treated. We dive into the history of eating disorders and how common misbeliefs about mental illness shape their treatment today. We examine how weight stigma impacts treatment and why so many EDs are considered “atypical.” Then, we offer some practical solutions for fixing a f*cked-up system by debunking common misconceptions. REFERENCES: Kazdin, C. (2023). What's eating us. St Martin's Press. Dell'Osso L, Abelli M, Carpita B, Pini S, Castellini G, Carmassi C, Ricca V. Historical evolution of the concept of anorexia nervosa and relationships with orthorexia nervosa, autism, and obsessive-compulsive spectrum. Neuropsychiatr Dis Treat. 2016 Jul 7;12:1651-60. doi: 10.2147/NDT.S108912. PMID: 27462158; PMCID: PMC4939998. Niedzielski A, Kaźmierczak N, Grzybowski A. Sir William Withey Gull (1816-1890). J Neurol. 2017 Feb;264(2):419-420. doi: 10.1007/s00415-016-8250-9. Epub 2016 Aug 8. PMID: 27502084; PMCID: PMC5306080. Harrop EN, Hutcheson R, Harner V, Mensinger JL, Lindhorst T. "You Don't Look Anorexic": Atypical anorexia patient experiences of weight stigma in medical care. Body Image. 2023 Sep;46:48-61. doi: 10.1016/j.bodyim.2023.04.008. Epub 2023 May 24. PMID: 37236121; PMCID: PMC10524894. Beaumont, P. J. V. (1994). Diagnoses of Eating Disorder or Dieting Disorders: What may We Learn from Past Mistakes? International Journal of Eating Disorders, 16(4). Beres, D. (2024, February 27). Eating disorders in men and boys aren't rare, but they may be harder to diagnose. Teen Vogue. https://www.teenvogue.com/story/eating-disorders-in-men Eating disorder statistics. National Eating Disorders Association. (2024, April 30). https://www.nationaleatingdisorders.org/statistics/ Guest, Lawson, N., Burak, E. W., Kaneb, N., & Mondestin, T. (2023, November 2). New federal rules seek to strengthen mental health parity. Center For Children and Families. https://ccf.georgetown.edu/2023/11/02/new-federal-rules-seek-to-strengthen-mental-health-parity/ Heiden-Rootes, K., Linsenmeyer, W., Levine, S., Oliveras, M., & Joseph, M. (2023). A scoping review of research literature on eating and body image for transgender and nonbinary youth. Journal of Eating Disorders, 11(1). https://doi.org/10.1186/s40337-023-00853-5 The Mental Health Parity and Addiction Equity Act (MHPAEA). CMS.gov. (n.d.). https://www.cms.gov/marketplace/private-health-insurance/mental-health-parity-addiction-equity Ramaswamy, N., & Ramaswamy, N. (2023, July 1). Overreliance on BMI and delayed care for patients with higher BMI and disordered eating. Journal of Ethics | American Medical Association. https://journalofethics.ama-assn.org/article/overreliance-bmi-and-delayed-care-patients-higher-bmi-and-disordered-eating/2023-07 Why BMI is a flawed health standard, especially for people of color. (n.d.). https://www.washingtonpost.com/lifestyle/wellness/healthy-bmi-obesity-race-/2021/05/04/655390f0-ad0d-11eb-acd3-24b44a57093a_story.html
In this episode, I talk with Maaike Vandermosten, Associate Professor in the Department of Neurosciences at KU Leuven, about the neural basis of developmental dyslexia, and neuroplasticity in recovery from aphasia.Vandermosten websiteVanderauwera J, Wouters J, Vandermosten M, Ghesquière P. Early dynamics of white matter deficits in children developing dyslexia. Dev Cogn Neurosci 2017; 27: 69-77. [doi]Beelen C, Vanderauwera J, Wouters J, Vandermosten M, Ghesquière P. Atypical gray matter in children with dyslexia before the onset of reading instruction. Cortex 2019; 121: 399–413. [doi]Phan TV, Sima D, Smeets D, Ghesquière P, Wouters J, Vandermosten M. Structural brain dynamics across reading development: A longitudinal MRI study from kindergarten to grade 5. Hum Brain Mapp 2021; 42: 4497-509. [doi]Clercq PD, Gonsalves AR, Gerrits R, Vandermosten M. Individualized functional localization of the language and multiple demand network in chronic post-stroke aphasia. bioRxiv 2024; 2024.01.12.575350. [doi]
It is a privilege to welcome author, coffee addict, podcast host, and speaker Isaac Mashman to The Jake's Take with Jacob Elyachar Podcast. Hailing from a single-parent home that fell on the lower end of the economic spectrum, Isaac grew up seeing and understanding what the lack of money and vision would result in. Atypical to many "modern" stories, Isaac was a top 10 student in his class and was bound for college, that is, when in his senior year of high school, he realized that a degree in marketing made no sense for his ambitions. After launching an apparel line called "Success Before Rest Apparel," he made his first couple of dollars online and began collecting information from various virtual mentors. Stepping away from hustling merchandise, he fell into the Network Marketing industry. He joined three companies four times, ultimately leaving the field to pursue something he had more control over. Over three years, he tried his hand at half a dozen business models, from drop shipping, social media work, and even launching a record label managing musical talent before the COVID-19 pandemic. Having to cancel a concert due to the early fear of the virus, the lack of freedom gave Isaac room to think about his ambitions and led him to what is now his vehicle, the public relations firm Mashman Ventures. He previously hosted the business and self-development-centered podcast Chase the Vision with Isaac Mashman (launched in June 2019), which he ended after 100 episodes in June of 2022. He is working on a new show that will merge the niches of business, celebrity, and entertainment that will launch in 2023. Isaac Mashman founded his first company, the public relations firm Mashman Ventures, on April 17, 2020. After a four-year run in that business, he decided to dissolve his company and launch Mashman Consulting Group on July 18, 2024. Taking the best aspects of their approach, expertise, and strategies, MCG was founded as the next evolution and marks the continuation of his work in personal branding and individual reputation management. On November 1, 2021, Isaac released his first book, Personal Branding: A Manifesto on Fame and Influence. The book became Amazon's number one new release in Public Relations and a Top 10 Best Seller in the category. He is working on a second edition, which will expand on the subject and is expected to be released in Fall 2024. On this episode of The Jake's Take with Jacob Elyachar Podcast, Isaac Mashman spoke about writing Personal Branding: A Manifesto on Fame & Influence and how Chase the Vision with Isaac Mashman Podcast enhanced his brand.Let's connect on social media! Visit my channels on:A) Facebook: https://www.facebook.com/JacobElyachar/B) Instagram: https://www.instagram.com/jacobelyachar/C) Threads: https://www.threads.net/@jacobelyacharD) TikTok: https://www.tiktok.com/@therealjacobelyacE) YouTube: https://www.youtube.com/@JacobElyacharBecome a supporter of this podcast: https://www.spreaker.com/podcast/jake-s-take-with-jacob-elyachar--4112003/support.
Are you feeling tired? Exhausted? Completely burnt out? If so, this episode is for you. Harvard physician Dr. Aditi Nerurkar reveals the groundbreaking science behind stress management and burnout prevention. Prepare to have your understanding of resilience completely transformed as we delve into practical strategies that can rewire your brain and revolutionise your approach to work and life. Dr. Nerurkar, a renowned expert in stress medicine and bestselling author of ""The 5 Resets"", gives invaluable insights on:
Episode 40 titled "What Is Rett Syndrome?", has International Rett Syndrome Foundation (IRSF) Family & Community Engagement Manager, Samantha Brant, share her and her daughter Macy's story, along with valuable information about the syndrome. Episode Summary: This episode of the Simple Questions Podcast features a discussion with Samantha Brant, a strong mother who helps raise funds and guide other parents through the Rett Syndrome journeys. Listen as Sam shares her and her daughter Macy's inspiring story of handling the challenges of Rett Syndrome. In this episode we discuss: 00:26 - Introducing Samantha Brant 01:36 - Reading Rett 9:05 - Involvement with IRSF 15:54 - What is it? 19:02 - Common Symptoms 23:00 - Atypical vs. Typical 25:48 - Known Causes & Risk Factors 28:46 - Caretaker Challenges 34:06 - Grieving Journey 39:21 - Options for Managing 44:14 - Learning More 48:09 - Conclusions Resources: International Rett Syndrome Foundation Raise a Glass Against Rett This episode includes the track 'RSPN' by Blank & Kytt. The song is used under the Creative Commons Attribution 3.0 Unported License. You can find more of Blank & Kytt's music here.
Contributor: Taylor Lynch, MD Educational Pearls: What is NMS? Neuroleptic Malignant Syndrome Caused by anti-dopamine medication or rapid withdrawal of pro-dopamenergic medications Mechanism is poorly understood Life threatening What medications can cause it? Typical antipsychotics Haloperidol, chlorpromazine, prochlorperazine, fluphenazine, trifluoperazine Atypical antipsychotics Less risk Risperidone, clozapine, quetiapine, olanzapine, aripiprazole, ziprasidone Anti-emetic agents with anti dopamine activity Metoclopramide, promethazine, haloperidol Not ondansetron Abrupt withdrawal of levodopa How does it present? Slowly over 1-3 days (unlike serotonin syndrome which has a more acute onset) Altered mental status, 82% of patients, typically agitated delirium with confusion Peripheral muscle rigidity and decreased reflexes. AKA lead pipe rigidity. (As opposed to clonus and hyperreflexia in serotonin syndrome) Hyperthermia (>38C seen in 87% of patients) Can also have tachycardia, labile blood pressures, tachypnea, and tremor How is it diagnosed? Clinical diagnosis, focus on the timing of symptoms No confirmatory lab test but can see possible elevated CK levels and WBC of 10-40k with a left shift What else might be on the differential? Sepsis CNS infections Heat stroke Agitated delirium Status eptilepticus Drug induced extrapyramidal symptoms Serotonin syndrome Malignant hyperthermia What is the treatment? Start with ABC's Stop all anti-dopaminergic meds and restart pro-dopamine meds if recently stopped Maintain urine output with IV fluids if needed to avoid rhabdomyolysis Active or passive cooling if needed Benzodiazapines, such as lorazepam 1-2 mg IV q 4hrs What are active medical therapies? Controversial treatments Bromocriptine, dopamine agonist Dantrolene, classically used for malignant hyperthermia Amantadine, increases dopamine release Use as a last resort Dispo? Mortality is around 10% if not recognized and treated Most patients recover in 2-14 days Must wait 2 weeks before restarting any medications References Oruch, R., Pryme, I. F., Engelsen, B. A., & Lund, A. (2017). Neuroleptic malignant syndrome: an easily overlooked neurologic emergency. Neuropsychiatric disease and treatment, 13, 161–175. https://doi.org/10.2147/NDT.S118438 Tormoehlen, L. M., & Rusyniak, D. E. (2018). Neuroleptic malignant syndrome and serotonin syndrome. Handbook of clinical neurology, 157, 663–675. https://doi.org/10.1016/B978-0-444-64074-1.00039-2 Velamoor, V. R., Norman, R. M., Caroff, S. N., Mann, S. C., Sullivan, K. A., & Antelo, R. E. (1994). Progression of symptoms in neuroleptic malignant syndrome. The Journal of nervous and mental disease, 182(3), 168–173. https://doi.org/10.1097/00005053-199403000-00007 Ware, M. R., Feller, D. B., & Hall, K. L. (2018). Neuroleptic Malignant Syndrome: Diagnosis and Management. The primary care companion for CNS disorders, 20(1), 17r02185. https://doi.org/10.4088/PCC.17r02185 Summarized by Jeffrey Olson MS2 | Edited by Meg Joyce & Jorge Chalit, OMSIII
VISIT US AT NCLEXHIGHYIELD.COM No matter where you are in the world, or what your schedule is like, access the entire course at www.NCLEXHighYieldCourse.com The NCLEX High Yield Podcast was featured on Top 15 NCLEX Podcasts! Make sure you JOIN OUR NEW VIP FACEBOOK GROUP! https://nclexhighyield.com/blogs/news/nclex-high-yield-quick-links A topic that confuses many, but listen to how Dr. Zeeshan breaks this bad boy down! Many people get overwhelmed with all the information that's out there, we keep it simple! Join us weekly for FREE Zoom Sessions and be one of the many REPEAT test takers that passed the exam by spending NO MONEY with NCLEX High Yield! NCLEX High Yield is a Prep Course and Tutoring Company started by Dr. Zeeshan in order to help people pass the NCLEX, whether it's the first time , or like the majority of our students, it's NOT their first time. We keep things simple, show you trends and tips that no one has discovered, and help you on all levels of the exam! Follow us on Instagram: @NCLEXHighYield or check out our website www.NCLEXHighYield.com Make sure you join us for our FREE Weekly Zoom Sessions! Every Wednesday 3PM PST / 6PM EST. Subscribe to our newsletter at nclexhighyield.com --- Support this podcast: https://podcasters.spotify.com/pod/show/nclexhighyield/support
Marisa Meddin, founder of Talk College To Me and the creator of The 7 Day College Admissions Crash Course For Parents, discusses how students can become the strongest possible college applicants they can be. Learn more about your ad choices. Visit megaphone.fm/adchoices