Podcasts about hhv

Isabel's Lyme/Mold/Parasite Journey Part 4 EPISODE SUMMARYIn this episode of The WellFuel Podcast, host Isabel Smith returns from a hiatus to share a personal update on her health journey. She reflects on her progress in managing Lyme disease and co-infections, celebrating nearly a year free from antibiotics, thanks to incorporating exosome treatments to support immune health. Isabel also discusses post-COVID viral management, the importance of liver and endocrine support, and the ongoing commitment to long-term wellness. Looking ahead, she's excited to dive deeper into these and similar health and wellness topics, featuring guest interviews and in-depth discussions based on listener requests.EPISODE HIGHLIGHTSIsabel's progress in healing from Lyme disease, Bartonella, Babesia, and relapsing feverSuccessfully staying antibiotic-free for nearly a year with exosome therapyManaging viral challenges like Epstein-Barr and human herpesvirus post-COVIDThe importance of liver detox, adrenal health, and sleep in the healing processPlans for future episodes featuring expert insights and listener-requested topicsCHAPTER MARKERS00:00- Welcome Back to the WellFuel Podcast00:17- Personal Health Update: Lyme Disease Journey02:08- Exosome Treatment and Health Screenings03:09- Herbal Support and Antibiotics05:55- COVID and Viral Challenges08:42- Liver Work and Clinical Insights10:38- Looking Ahead: Plans for 2025HELPFUL DEFINITIONSPrenuvo Scan: A Prenuvo scan is a full-body MRI scan that uses magnetic fields to image the body and screen for disease. Prenuvo scans are non-invasive, radiation-free, and can detect hundreds of conditions. “Herxing”: A Herxheimer reaction, also known as a Jarisch-Herxheimer reaction, is a temporary worsening of symptoms that can occur after starting antibiotic treatment for certain bacterial infections, such as Lyme disease, syphilis, and leptospirosis. Liver Flukes: Liver flukes are parasites that can infect humans and cause liver and bile duct disease.Epstein-Barr: Epstein-Barr virus, or EBV, is one of the most common human viruses in the world. EBV is also known as human herpesvirus 4 and is a member of the herpes virus family. Most people will get infected with EBV in their lifetime, especially in childhood, and will not have symptoms. EBV infections in children usually do not cause symptoms, or the symptoms are not distinguishable from other mild, brief childhood illnesses.Herpes 6: Human herpesvirus 6 (HHV-6) is a common virus that causes roseola in children. Like all herpes family viruses, HHV-6 stays in your body for life but usually remains dormant (inactive).  This is not the same variant of the Herpes virus that causes genital Herpes or cold sores - that's Herpes Simplex 1 and 2. -----------------------------The WellFuel Podcast explores gut health, detox, hormones, mold, and more—hosted by Isabel Smith, MS, RD, CDN. Join Isabel as she shares her insights and chats with experts from across the wellness spectrum, to help support you on the path to health and wellness.Learn more about Isabel Smith Nutrition: Visit Our WebsiteFollow along on social media:YouTube:@isabelsmithnutrition1Instagram:@isabelsmithnutritionPinterest:@isabelsmithnutritionWant to learn more about how Isabel Smith Nutrition can help support you on your journey to better health? ⁠Book a call with us today:Schedule Here

Send us a textYo, yo, yo what's up all you stoners!  Mr and Mrs Weedman are in the studio for their last show of the 2024 year. It's that funny stretch of time between Xmas and New Years Day when no one know what day it is, so you might as well get baked and stick around for the show. Mr and Mrs "get normal" toking on Lemon Pepper bud from Big Earl's garden and then get right into delivering the latest cannabis news, research, hot topics and opinions from all around this big beautiful world. Mr Weedman goes deep on THCV and the future of AI being used to design new strains, he explains HHV and Delta 9 similarities, and he shares another piece that discusses the decline in teen cannabis consumption since legalization.  Mrs Weedman shares a perspective on full spectrum vs isolate cannabis, the differences between them and how to use them during your work day, an update on Americans opinion's changing on the safety of cannabis and psychedelics, and she breaks down the different types of rolling papers available in today's market. Thanks for listening and as always, hit us up!TWITTER: @weedman420podYouTube: Weedman420 ChroniclesEMAIL:  weedman420chronicles@gmail.comSHOP: www.eightdecades.comIG: @eightdecadesEMAIL: eightdecadesinfo@gmail.com*Sign up for our newsletter and get free shipping on your 1st order!*#ImHigh #Cannabis #StomptheStigma #HomeGrow #FreethePlant #Stoners #Burners #rosin #liverosin #Potheads #Vipers #CannabisEducation #CannabisResearch #Weed #Marijuana #LegalizeIt #CannabisNews #CBD #Terpenes  #Podcast #CannabisPodcast #eightdecades #LPP #Lifestyle #HealthyLifestyle #NaturalMedicine #PlantMedicine #News #Research #MedicalMarijuana #Infused #420 #Education #Health #Wellness #WorldNews #Gardening #budtender #kief #hemp #dabs #hash #joints #edibles #gummies #tincture #vapes #esters #pauliesayssmokesmart #lastprisonerproject #wintersolstice #solstice #aiArticle Links:* https://cannabis.net/blog/opinion/ai-to-create-new-weed-strains-gsd-with-20-thcv-is-a-new-sciencebased-cannabis-strain* https://www.eastbaytimes.com/2024/12/18/full-spectrum-vs-isolate-cannabis-what-you-need-to-know-for-your-workday/?utm_source=flipboard&utm_content=topic/cannabis* https://blog.leafbuyer.com/hhc-vs-delta-9-differences-similarities/* https://www.greenstate.com/lifestyle/types-of-rolling-papers/?utm_source=flipboard&utm_content=topic/cannabis* https://businessofcannabis.com/whats-on-the-horizon-for-cannabis-in-2025/COPYRIGHT 2021 WeedMan420Chronicles©

Godfather Don... you know the name, or at least you should. Check the credits; the man born Rodney Chapman has worked with most of your favourites, including Kool Keith, Cormega and Screwball. His solo catalogue is exemplary, and his work on Hydra Entertainment is damn near mythical at this point. Veteran New York Emcee and Producer Godfather Don pulls up to the pod for a rare and exclusive interview. Don doesn't talk much, so we listened for the most part because nerdy details and unearthed gems were released at will. Before heading out with his saxophone to meet his jazz band for a session, Don opens up about Flatbush Hip-Hop history, how his writing style has evolved, and why he describes his creative process as "meat and potatoes". We also deep dive into the making of his brand new album Thesis (dropping on 30 August 2024!) and share some exclusive snippets from some of the album cuts - because we're connected like that.Respect to the HHV team for connecting the dots and creating an intricate plot.Pre-order the new Thesis album by Godfather Don at www.hhv.de: godfather-don.lnk.to/thesisAvailable in limited quantities on 4LP (incl. all instrumentals), 2LP (vocal tracks only), double cassette (incl. all instrumentals), 2CD (incl. all instrumentals) and digitally on all major platforms.Connect with Breaking AtomsInstagramFacebookTwitterFollow SumitInstagramTwitterFollow ChrisInstagramTwitter Hosted on Acast. See acast.com/privacy for more information.

Dr. Guy Handley, Assistant Professor of Medicine with the Division of Infectious Diseases, USF Morsani College of Medicine, provides an overview of Human Herpesvirus 6 in Stem Cell Transplant Patients. Dr. Handley uses clinical cases to describe several scenarios related to HHV6 infection. Topics discussed include background, HHV6 latency, reactivation, clinical presentation, encephalitis, treatment strategies, and outcomes. Guidelines for HHV care are also discussed. Dr. Handley closes by discussing controversies and future directions in HHV6 management.

Welcome to a special episode of our Tick Boot Camp Podcast, where we dive deep into the world of chronic illness, focusing on Lyme disease. Today, we're honored to have Mandy Meehan, a Functional Nutritional Therapy Practitioner, Certified Dietary Supplement Professional, and Certified Lyme Specialist, share her incredible journey of battling and overcoming Lyme disease. Joining us as a special guest co-host is MTV Reality TV Star Kendall Darnell along with host Matt Sabatello from Tick Boot Camp, bringing their insights and experiences to today's discussion. Episode Highlights: Introduction to Mandy Meehan: We start by introducing Mandy, who lives in Oklahoma with her husband, James, their son, Jace, and another child on the way. Mandy's story begins with her falling incredibly sick just two weeks before her wedding, leading to a 7+ year journey battling over 21 different infections, including Lyme Disease, Bartonella, Babesia, EBV, HHV-6, and more. Mandy's Battle with Chronic Illness: Mandy shares the challenges she faced, including severe food intolerances, hormonal imbalances, hypothyroidism, and neurological issues. These conditions rendered her unable to work or care for herself, pushing her to the brink of despair. Turning Point: Determined to reclaim her life, Mandy embarked on an exhaustive journey of research into nutrition, supplement protocols, and healing strategies. This not only sparked her passion for functional wellness but also led her to become a Functional Nutritional Therapy Practitioner. Expertise and Empowerment: Mandy discusses her specialty in helping people with Lyme & co-infections, chronic fatigue, and toxicity issues, focusing on digestive health, thyroid function, and hormonal balance. Her approach emphasizes the belief in the body's ability to heal through proper nutrition and lifestyle changes. Navigating Life with Lyme: The conversation shifts to Mandy's insights on parenting with Lyme, managing relationships, addressing mold exposure, and the ups and downs of living with chronic illness. She highlights the importance of community and sharing success stories to inspire others. Healing and Giving Back: Mandy reveals the strategies and treatments that were pivotal in her recovery. She shares how she now uses her experience to give back to the community, helping others navigate their paths to wellness. Hosts Matt Sabatello and Kendall Darnell: Host Matt Sabatello and special guest co-host Kendal Darnell share their perspectives, underscoring the importance of validation, community building, and the belief in healing. They discuss the role of their podcast in spreading awareness and offering hope to those affected by Lyme disease and tick-borne illnesses. Closing Thoughts: Mandy Meehan's story is a powerful reminder of the resilience of the human spirit and the potential for recovery against the odds. Her journey from suffering to healing and now to empowering others is a testament to the strength found in knowledge, support, and the relentless pursuit of health. We thank Mandy for a deeply insightful and inspiring episode. Resources: For more information on Mandy Meehan and her work, visit her website. To learn more about Tick Boot Camp and access resources for Lyme disease and tick-borne illnesses, visit our Tick Boot Camp website. Thank you for tuning in to this special episode. If you or someone you know is battling Lyme disease or any related condition, we hope you find solace and solutions in Mandy's story. Remember, healing is possible, and you are not alone in this journey.

A new paper entitled “Isorhamnetin protects porcine oocytes from zearalenone-induced reproductive toxicity through the PI3K/Akt signaling pathway” investigated the effects of a natural flavonoid called isorhamnetin on the damage caused by a toxin called Zearalenone (ZEA) to pig oocytes (immature egg cells). Zearalenone (ZEA) is a harmful mycotoxin found in moldy grain like corn, oats, and millet that can cause irreversible damage to the reproductive system of animals and humans. It can cause reproductive disorders by binding to estrogen receptors and has been shown to impair the development of sperm and oocytes in humans and animals. ZEA can cause oxidative stress that leads to the production of reactive oxygen species (ROS), which can be harmful and contribute to cell death. ZEA can also disrupt pregnancy, inhibit the meiosis of oocytes, and induce mitochondrial damage and stress in the maturation of oocytes. Since ZEA is heat-stable and cannot be completely eliminated from the food chain, it is important to explore potential compounds that can protect against ZEA-induced damage to oocytes. In recent years, natural substances called flavonoids, which have antioxidant properties, have gained attention for their ability to support the development of oocytes. For example, quercetin has been found to increase the proportion of porcine oocytes developing into blastocysts, while kaempferol has shown potential in reducing the negative effects of aging on the development of porcine oocytes by improving mitochondrial function and reducing oxidative stress. Isorhamnetin is a compound found in the herb ginkgo biloba and in foods like pears, onions, and peanuts. It has various pharmacological activities, such as being an antioxidant, anti-inflammatory, and antiviral.     Isorhamnetin acts as an antioxidant by decreasing the production of reactive oxygen species (ROS) and increasing the expression of SOD2 protein, which helps protect against oxidative stress. This study found that isorhamnetin can protect the oocytes from ZEA-induced damage by improving their development, reducing oxidative stress, preventing mitochondrial dysfunction, and inhibiting apoptosis. This research provides a potential solution for reproductive toxicity caused by ZEA and treating female infertility. Mold Toxicity and Ginkgo Biloba Clinical Applications Ginkgo biloba is rich in isorhamnetin as well as other powerful flavonoids like quercetin, kaempferol, and luteolin which makes it the perfect herb for patients with mold toxicity. Ginkgo biloba has many benefits including anti-inflammatory, antioxidant, antiviral, anticoagulant, anti-obesity, hypolipidemic, hypotensive, anti-diabetic, anti-cancer, adaptogenic, and it protects the brain, eye, inner ear, heart, liver, cardiovascular system, reproductive system, lungs, and kidneys. Patients with mold toxicity tend to have reactivated herpes viruses like EBV, CMV, and HHV-6 and ginkgo biloba is effective against these types of viruses as explained in this article. I use VascuSelect from Moss Nutrition which contains 120 mg of standardized ginkgo biloba extract along with grape seed extract and mango extract to further support microcirculation. 120 mg of ginkgo biloba twice a day is the usual dose for this versatile herbal medicine. If you're a practitioner who sees patients with mold toxicity and/or infertility, then VascuSelect should be considered an important part of your protocol. Click here to learn more about the Hedberg Institute Membership to take your functional medicine practice to the next level.

Daten müssen als Schlüssel zu einer nachhaltigen Verkehrswende betrachtet werden – das sagt Andreas Helferich, Professor für International and Digital Management an der ISM in Stuttgart. In der neuen Folge von "ISM Perspectives on: Reinventing Public Transport" sprechen wir mit ihm über diese Potentiale datenbasierter Innovationen im Bereich des öffentlichen Nahverkehrs: Wie könnten Mobilitätskonzepte der Zukunft aussehen? Wie müssen Plattformen für Nutzer*innen gestaltet sein? Und welche positiven Effekte für die Umwelt können aus einer solchen Transformation resultieren? Das alles und mehr erfährst Du in der aktuellen Folge unseres Podcasts. Berichtigung: In der Folge ist an einer Stelle von den "HHV hop Bussen" die Rede. Der Akteur, der hinter dem Angebot steht, ist aber nicht der Verkhresbetrieb (HHV), sondern der Verkehrsverbund (HVV).

Kobe and John talk with Iain Granger of HHV and advanced.research. We discuss Iain's career, style and plans for expanding advanced research into a fully fledged fashion and outdoor community. Iain has great taste and an infectious passion for clothes and curation, and we're honored to get a chance to talk with him and pick his brain about new brands.  Follow us on social media: @raincheckpod, Iain: @ixgranger, advanced.research: @advanced.research Kobe:@rc.kobe, John: @johnn_gal

There are a select few people who have been on the show twice and Vice Beats is now one of them. We caught up with the Musician, Producer and friend of the show as he gears up to release his new album, Aspects (which is dope by the way). Vice shares what it was like to produce an album during the pandemic, having to adjust to recording alone, the importance of family and being hands-on with every aspect of the marketing and promotion. Some people make music and that's cool, but this guy really writes his lifetime in between the paper's lines.Pre-order 'Aspects' on vinyl from HHV: https://www.hhv.de/shop/en/item/vice-beats-aspects-978733Special thanks to Andy Kettle at Steaming Kettle PR for helping to arrange this interview.Connect with Breaking AtomsInstagram: https://www.instagram.com/breaktheatomsFacebook: https://www.facebook.com/breaktheatomsFollow SumitInstagram: https://www.instagram.com/hiphopchronicleTwitter: https://www.twitter.com/hiphopchronicle Hosted on Acast. See acast.com/privacy for more information.

These last three weeks, LeeLee has found the movies to be subpar. Will Jack end his mediocre streak with Baby Driver? Or will we lose Leeann forever in a pit of despair? Let's talk about music, car chases, and a whole lot of action bukkake in today's episode of HHV!

In this research summary we look at the role of reactivated human herpesviruses (HHV) in ME/CFS and Long Covid. This is because a number of recent studies have implied that HHV's could be involved in disease pathology causing and perpetuating symptoms. And because this might lead to effective treatments and diagnostic tests. 

For more information on this topic or to schedule a consultation please visit us at http://WhatIsHashimotos.com Hashimoto's and lifestyle changes. I like this. I like this topic because it's so underappreciated, it's astonishing. And I think it's because Hashimoto's is still kind of misunderstood. I've been fortunate enough. I think I've been training with doctors from the get-go, from the time I got involved with this, who were the doctors who brought Hashimoto's out of the woodwork and dusted it off. Dr. Hashimoto said most thyroid problems were autoimmune back in the 19th, 11 or 12th, of the last century. And then everybody made fun of him and it kind of went away, and then my mentor brought it back, and then his mentor and him worked together to work out the autoimmune prospect of it, and as a result, we look at it as a disease. And when you're looking out for diseases, you're usually looking for pathogens. You've probably heard of, it's Epstein-Barr virus, a cytomegalovirus. It's HHV-6 virus, it's Lyme disease, and all of those can be triggers. The alternative medical doctors, or the alternative medical doctors that call themselves functional doctors or integrated doctors, they're still looking for the big time disease. They're still looking for all of those things I just told you and more. It's heavy metals, and all of those things can play a part in this. But really, the solutions are not exotic. It's food. It's toxins. Toxins are big. I think you can understand there's a lot of toxins flying around, but lifestyle's huge. Lifestyle is huge, and lifestyle changes are things that when you're doing them, they alter physiology in such a way that they flare up in inflammation, and life is kind of inflammatory. And then they ultimately create an immune response against your thyroid. Right off the top of my head, the number one lifestyle trigger for autoimmunity is, and specifically for Hashimoto's is, stress, because stress hormones cause your adrenal glance to put out a lot of hormones that create inflammatory responses. They put out adrenaline and noradrenaline and they put out aldosterone, which raises your blood pressure. And they put out cortisol, which screws up your blood sugar if too much is put out, and then that creates inflammation and all that type of stuff, and that flares it up. So, stress is like the number one trigger, I think, and it's also the number one lifestyle perpetuator. And it's one of those things that a lot of people usually have to deal with once we get them in control by herbs and botanicals, breathing techniques, taking a walk, praying, whatever it is. But stress is a big deal. And a lot of the other ones are very obvious. I mean, if you're a smoker, you're sucking up a ton of toxins into your system, and I'm not admonishing you, okay? Smoking is something that many of us might have done at some point in our life and then got smart and quit, and it's not easy to quit. But I'm just saying, every time you smoke a cigarette, you decrease oxygen to your brain, but you take in so many toxins. Oh, my God. And those toxins are, in and of themself, what triggers the Hashimoto's. http://powerhealthtalk.com http://drmartinrutherford.com Martin P. Rutherford, DC 1175 Harvard Way Reno, NV 89502 775 329-4402 http://powerhealthreno.com https://goo.gl/maps/P73T34mNB4xcZXXBA

20 Jahre HHV. Von Hip Hop Vinyl und Mailorder zum contemporary Fashion Store. Wir grüßen aus Berlin und um etwas genauer zu sein, aus den heiligen Hallen von HHV. Unser heutiger Gesprächspartner ist Benedict Ernst, seines Zeichens der Head of Buying, mit dem wir uns über seine Tätigkeit als Einkäufer und über die Geschichte des Berliners Stores unterhalten haben. HHV feiert dieses Jahr sein 20-jähriges Jubiläum und alle, die wie wir den smarten Stil lieben wissen, dass sich beim Berliner Store so einiges getan hat. Ganz großes Ausrufezeichen ist das Brand Portfolio wie man es ansonsten nur in einem hervorragend sortierten britischen Store vermuten würde. So finden wir neben Schuhen von Mephisto und Clarks Originals, Sneaker von adidas Originals und New Balance, Klassiker aus dem Hause Barbour und Fred Perry, auch Kleidungsstücke internationaler und japanischer Outdoor- oder Heritage-Marken. Was als kleiner Plattenladen in Friedrichshain begann, wurde bald zu einem Onlineshop von Rang und Namen, der heute auch für unsere Subkultur eine wichtige Anlaufstelle ist. Ihr erfahrt natürlich mehr zu den Ursprüngen von HHV und zur heutigen Kundenbindung. Denn der Berliner Store tut alles dafür seine Kundschaft mit Informationen und Nerdwissen zu beglücken. Wir dachten uns, es ist bestimmt sehr spannend für euch zu erfahren, wie denn die Arbeit eines Einkäufers aussieht und wie der Prozess vom Ordertermin bis zur Anlieferung aussieht. Hier ist Bene für uns der perfekte Gesprächspartner. Er ist seines Zeichens der Head of Buying by HHV und ein innovativer Kreativer, der immer auf der Suche nach neuer Inspiration ist. Viel Spaß mit Bene von HHV und der neuesten Episode von Casual Madness, dem Podcast von Sapeur – One Step Beyond! Wir freuen uns natürlich über euer Feedback. Und schickt uns gerne weiter Anregungen zu neuen Themen / Gesprächspartner oder auch konstruktive Kritik. Immer her damit! Links https://www.hhv-mag.com/feature/the-best-is-yet-to-come/

Are you aware of the devastating effects of mold infestation on your health and your whole being? Learn how to protect yourself and your family before it's too late!Today, Dr. Kylie engages in a super informative discussion with Erik Johnson. His involvement in the early study of Chronic Fatigue Syndrome (CFS) and how mold makes people sick has led to perhaps one of the most astonishing discoveries in healthcare. To share his knowledge with the public, Erik co-hosts the Exposing Mold Podcast, where they discuss the growing topic of toxic mold, its effects on human/environmental health, and novel theories on why Erik believes it is sickening so many.Erik is the prototype and survivor of the Incline Village, Nevada inception of the Chronic Fatigue Syndrome, creator of Erik Style Mold Avoidance, author of "The Role of Toxic Mold in Chronic Fatigue Syndrome," U.S. Veteran, and the man responsible for saving the lives of thousands of people suffering from mold illness.So if you're experiencing chronic fatigue and don't know why, check your environment for mold infestation and take immediate steps to eliminate the cause of your illness. Discover how you can protect yourself and your family from the devastating effect of mold in this episode of Beyond the Diagnosis with Dr. Kylie. “As a prototype for the syndrome—somebody who was used by Dr. Gary Holmes—they lifted my symptoms and signs right out of my medical chart to serve as a matrix for this new syndrome. Basically, this makes me qualified to ask or even demand that this research be done.”- Erik Johnson In This Episode:- Who is Erik Johnson, and what does he do?- How Erik got involved in the study of Epstein-Barr Virus (EBV)/ Chronic Fatigue Syndrome (CFS) and how mold is making people sick- The reason researchers behave the way they do- What to do if you've been exposed to mold - Different types of mold, how to detect them, and remediation techniques you can use to protect yourself- Rewriting CFS definitions - Dr. Kylie explains how to diagnose the presence of a virus by looking at a patient's blood work- The discovery of human herpesvirus 6 (HHV-6) and its link to CFS- How The Lake Tahoe Mystery Illness Outbreak challenged virologists and what Erik can say about itAnd more!Resources:- Sign up for Dr. Kylie's live event February 20-22, 2023 - Chronic Fatigue Syndrome: A Working Case Definition by Dr. Gary P. Holmes- Mystery Illness Outbreak in Lake Tahoe- The Role of Toxic Mold in Chronic Fatigue Syndrome by Erik Johnson- Why Are My Labs Normal? Your guide to reading your own blood work; no medical background needed- Join the 90-Day Coaching Program with Dr....

Das nächste große Highlight auf der Liste von Raphi und Lenz steht vor der Tür! In einem wunderschönen Wohnzimmer in Pullach bei München werden die beiden von keinem Geringeren als Produzent und Fotograf, TOM DOOLIE, empfangen. Tom ist in der deutschen HipHop-Szene seit Langem nicht mehr wegzudenken. Unter anderem durch Collabos zusammen mit Cap Kendricks, LUX, Yrrre oder Edgar Wasser ist er einer der geschätztesten Produzenten des Landes. Mit seinem besonderen Blick auf die Ästhetik von Bildern, hat sich Tom aber auch als Fotograf einen Namen gemacht und konnte bereits Zusammenarbeiten mit HHV, oder dem FC Bayern München eintüten. Außerdem gibt es bei "WER WAR DAS?" eine Überraschung. Was das bedeutet? Hört selbst!

Almut Boller: Keine Zeit für Entspannung – für die Thermen, Kur- und Heilbäder in Hessen stehen im dritten Jahr in Folge alle Zeichen auf Alarmstufe Rot. Almut Boller, Geschäftsführerin des Hessischen Heilbäder-Verbandes HHV, und die dem Verband angehörenden 30 Kurstädte und Heilbäder machen sich Gedanken, wie man sich im drohenden kalten Winter 2022/23 aktiv einbringen kann. Einerseits, um die erneut vor Schließung stehenden Thermen zu retten, andererseits, um der Bürgerschaft im Falle eines Falles als Wärmezentren zur Verfügung zu stehen. Harter Tobak.Zum Thema: Die Bundesregierung hat den Notfallplan Gas in Gang gesetzt und die Stufe 2 ausgerufen. Verschlechtert sich die Gasversorgung vor dem Hintergrund des Ukraine-Konfliktes weiter, stehen die Thermen der Heilbäder und Kurorte in Hessen erneut vor der Schließung. Alternativ schlägt der Hessische Heilbäderverband eine Öffnung als Wärmezentren vor.„Wir wollen die Thermen der Heilbäder und Kurorte in Hessen in diesem Herbst und Winter bewusst öffnen und als Wärmezentren einrichten,“ erklärt der Vorsitzende des Hessischen Heilbäderverbandes, Bürgermeister Michael Köhler. „Damit schaffen wir ein Gesundheitsangebot und bieten den Bürgerinnen und Bürgern eine Möglichkeit, sich aufzuwärmen. Denn treffen die schlimmsten Befürchtungen ein, werden die privaten Haushalte deutlich an Energie einsparen und die Raum- und Wassertemperaturen drosseln müssen.“„Die Thermen und Bäder werden so zu Begegnungsräumen mit einer Vielzahl vor Vorteilen,“ erläutert die Geschäftsführerin des Hessischen Heilbäderverbandes Almut Boller.§ Patienten mit Rheuma, Bewegungseinschränkungen etc. können ihre rehabilitativen Maßnahmen fortsetzen§ Ältere Mitbürgerinnen und Mitbürger erhalten ihre Bewegungsfähigkeit§ Ausgleich für „Frustrationen“, die durch die Energieeinsparmaßnahmen entstehen(Weitere) Walk-Män-Podcast CLASSICS zu den Themen Heilbäderverband und Kurwesen:14. Walk-Män: Im Gespräch mit HHV-Geschäftsführerin Almut Boller19. Walk-Män: Pressekonferenz: Kurorte in der "schlimmsten Krise"39. Walk-Män: Die Rückkehr der Kur, Teil 1 - mit Almut Boller (HHV)40. Walk-Män: Die Rückkehr der Kur, Teil 2 - mit Dieter Adt (DEHOGA)Kontakt Hessischer Heilbäderverband HHV: www.hessische-heilbaeder.deKontakt Hessischer Heilbäderverband HHV auf Facebook:www.facebook.com/HeilbaederZu den Walk-Män-Projekten und zum Podcast auf der Walk-Män-Homepage.Kontakt Ralf Baumgarten / Walk-Män:Mobil: 0172 6612032Homepages: https://walkmaen.de/ https://mein-blaettche.deEMail:info@walkmaen.deFacebook: https://www.facebook.com/walkmaenorbWenn Dir gefällt, was Du hörst, dann abonniere den Podcast bei Apple-Podcast, Spotify, YouTube, Deezer, Amazon-Music, Google-Podcast und überall, wo es Podcasts zu hören oder zu sehen gibt. Toll wäre auch ein Feedback direkt an mich und (oder) eine Bewertung auf Apple-Podcast oder Spotify.Wenn Du den Walk-Män-Podcast aktiv als SupporterIn unterstützen und seine Arbeit auf einer solide Basis stellen willst, dann kannst Du das über ein Abonnement bei STEADY machen. Drei Support-Möglichkeiten stehen Dir zur Auswahl: https://steadyhq.com/de/walkmaenBleib wach, gesund und aufmerksam, Dein Ralf Baumgarten

Almut Boller: Keine Zeit für Entspannung – für die Thermen, Kur- und Heilbäder in Hessen stehen im dritten Jahr in Folge alle Zeichen auf Alarmstufe Rot. Almut Boller, Geschäftsführerin des Hessischen Heilbäder-Verbandes HHV, und die dem Verband angehörenden 30 Kurstädte und Heilbäder machen sich Gedanken, wie man sich im drohenden kalten Winter 2022/23 aktiv einbringen kann. Einerseits, um die erneut vor Schließung stehenden Thermen zu retten, andererseits, um der Bürgerschaft als Wärmezentren zur Verfügung zu stehen. Zum Thema: Die Bundesregierung hat den Notfallplan Gas in Gang gesetzt und die Stufe 2 ausgerufen. Verschlechtert sich die Gasversorgung vor dem Hintergrund des Ukraine-Konfliktes weiter, stehen die Thermen der Heilbäder und Kurorte in Hessen erneut vor der Schließung. Alternativ schlägt der Hessische Heilbäderverband eine Öffnung als Wärmezentren vor. § Patienten mit Rheuma, Bewegungseinschränkungen etc. können ihre rehabilitativen Maßnahmen fortsetzen § Ältere Mitbürgerinnen und Mitbürger erhalten ihre Bewegungsfähigkeit § Ausgleich für „Frustrationen“, die durch die Energieeinsparmaßnahmen entstehen Walk-Män-Podcasts zu Heilbäderverband und Kur: 14. Walk-Män: Im Gespräch mit HHV-Geschäftsführerin Almut Boller 19. Walk-Män: Pressekonferenz: Kurorte in der "schlimmsten Krise" 39. Walk-Män: Die Rückkehr der Kur, Teil 1 - mit Almut Boller (HHV) 40. Walk-Män: Die Rückkehr der Kur, Teil 2 - mit Dieter Adt (DEHOGA) 80. Almut Boller und die KurVISION – Die Rückkehr der Kur, Teil 3 Kontakt Hessischer Heilbäderverband HHV: www.hessische-heilbaeder.de Kontakt Ralf Baumgarten: Mobil: 0172 6612032 Homepages: https://walkmaen.de/ https://mein-blaettche.de EMail:info@walkmaen.de Facebook: https://www.facebook.com/walkmaenorb Wenn Dir dieser Podcast gefällt, dann abonniere ihn bei Apple-Podcast, Spotify, YouTube, Deezer, Amazon-Music oder Google-Podcast. Toll wäre auch ein Feedback direkt an mich und eine Bewertung auf Apple-Podcast oder Spotify. Wenn Du den Podcast als SupporterIn unterstützen willst, dann kannst Du das über ein Abonnement bei STEADY machen. https://steadyhq.com/de/walkmaen Bleib wach, gesund und aufmerksam, Dein Ralf Baumgarten

Jim stellt uns heute Perlen aus der Welt des Garagenpunk vor. Unvergleichlich erfrischend und mal wieder unschlagbar. Für alle Nerds unter uns und die, die es werden wollen. Mit the Chob, the third bado, Jacqueline Taieb und den Misanthropes Unsere Auffälligkeit der Woche ist für alle interessant, die auf der Suche nach besonderem Vinyl sind (Anost, Bis aufs Messer und HHV). Wer nicht genug von uns bekommen kann... Unsere E-Mail-Adresse lautet: wmruv2021@gmail.com Mehr und auch andere (!) Inhalte gibt es von uns auf Social Media: YouTube Instagram FacebookDu möchtest deinen Podcast auch kostenlos hosten und damit Geld verdienen? Dann schaue auf www.kostenlos-hosten.de und informiere dich. Dort erhältst du alle Informationen zu unseren kostenlosen Podcast-Hosting-Angeboten. kostenlos-hosten.de ist ein Produkt der Podcastbude. Gern unterstützen wir dich bei deiner Podcast-Produktion.

Coffy is the color for today's episode of HHV. Let's talk about a baaaaaad bitch and hear some unwanted info about Jack's wiener.

After the Muslim terror attack on a synagogue in Texas, Sniffy Joe the meat puppet went to the microphones and said he doesn't know why the Muslim terrorist used anti-semetic and anti-Israel language. I guess we'll just never know.  We have a Duracoat Finish segment for you again, but this week it is not a firearm, but something that pairs well with a firearm. During our Brownells Bullet Point, Professor Paul will consider some suggested reading before you go out and spend money on more stuff.  For our SOTG Homeroom from CrossBreed Holsters, we discuss being dangerous on demand, even inside your house of worship. We will remind you of the Legion of Michael Church Security program that is available to all.   Thanks for being a part of SOTG! We hope you find value in the message we share. If you've got any questions, here are some options to contact us: Send an Email Send a Text Call Us Enjoy the show! And remember…You're a Beginner Once, a Student For Life! TOPICS COVERED THIS EPISODE [0:02:25] New video partner: SCCY Firearms Cold Weather Concealed Carry video www.full30.com [0:08:55] Bob Saget Update: Did we call it or what? www.tmz.com Dr. Peter McCullough on Joe Rogan open.spotify.com/episode/0aZ Dr. Robert Malone on Joe Rogan open.spotify.com/episode/3SC [0:20:39] Duracoat Finished Firearms - Duracoat University TOPIC: AOR1 helmet from HHV turned White with Duracoat Mission Specific Get Yours: www.duracoatfirearmfinishes.com [0:28:15] Zach “The Shipping Ogre” put out a book. Please consider checking it out! Inferni Ensium: Conception https://amzn.to/3IlUFgd [0:32:40] Brownells Bullet Points - Brownells.com TOPIC: How do I know what stuff to buy? READ/STUDY https://amzn.to/3rlcJ30  Pipe Hitters Guide to CIDC Huge thanks to our Partners: SDS Imports | Brownells | CrossBreed | Duracoat | Hi-Point Firearms [0:46:27] The concept of the "Echo Chamber" [0:53:56] SOTG Homeroom - CrossBreedHolsters.com TOPIC: Legion of Michael Church Security training. “But, I'm not paranoid.”  www.legionofmichael.com Check out the L.o.M. Book https://amzn.to/3fy0Y3K [1:07:02] UPDATE: Hostages Safe: British Hostage Taker Dead: the Rabbi and the Pakistani www.sofmag.com [1:23:26] WATCH: Joe Biden doesn't understand why the guy making Anti-Semitic Comments took a Synagogue Hostage www.louderwithcrowder.com FEATURING: Madison Rising, Jarrad Markel, Paul Markel, SOTG University PARTNERS: SDS Imports, Brownells Inc, CrossBreed Holsters, DuraCoat Firearm Finishes, Hi-Point Firearms FIND US ON: Full30, Parler, MeWe.com, TikTok, iTunes, Stitcher, AppleTV, Roku, Amazon, GooglePlay, YouTube, Instagram, Facebook, Twitter, tumblr SOURCES From www.sofmag.com: “Around 9 p.m., the HRT — hostage rescue team — breached the synagogue, they rescued the three hostages, the suspect is deceased,” Colleyville Police Chief Michael Miller. Background The hostage taker at first was thought to be Muhammad Siddiqui be the brother of Aafia Siddiqui, a Palestinian in prison for life according to Israel Times. However, updates state that the brother was uninvolved, according to the prisoner and the Siddiqui family UK Foreign, Commonwealth and Development Office (FCDO) spokesperson said: “We are aware of the death of a British man in #Texas and are in contact with the local authorities,” the Guardian reported. (Click Here for Full Article)   From Amazon.com: Building upon the widespread popularity of the original Pipe Hitters Guide, this book will take the lessons from the original text and build upon them. The Citizens Irregular Defense Corps is a modern incarnation of many successful programs used throughout history for the defense of a community during times of crisis or prolonged emergency. (Click Here for the Book)   From www.tmz.com: Bob Saget wouldn't be the first one in his immediate family to die from a heart attack ... it's what killed 3 of his uncles. In Bob's book, "Dirty Daddy: The Chronicles of a Family Man Turned Filthy Comedian," he references that 3 of his uncles died from a heart attack between the ages of 37 and 41. When Bob was 8, his Uncle Ozzie died at 40 from a heart attack while chasing some kids down the block after they stole a tire. (Click Here for Full Article)

Seri olarak konuşmayı planladığımız kardiyomiyopatilerin girizgahını kazanılmış bir kardiyomiyopati olan miyokardit ile yapmak istedim. Tanım olarak, miyositlerin nekrozu ve/veya dejenarasyonu ile seyreden, miyokardın inflamatuar hastalığı olan miyokarditin sıklığı tam bilinmemekte. Aslında bilinmemesinin nedeni basit!: Bir hasta, acile kardiyak arrest olarak geldiğinde, ROSC sağlanamadığı taktirde hasta olası bir ön tanı ile defnedilmekte. Adli açıdan şüpheli ölüm düşünülmüyorsa, hasta otopsiye gitmemekte. Yaşlı popülasyon düşünüldüğünde eşlik eden ek hastalıklar ve buna bağlı oluşan kronik inflamatuar süreçler bizi daha çok koroner iskemiye bağlı gelişen aritmilere, akut dekompanze kalp yetmezliğine, kardiyojenik şoka veya ani kardiyak ölüme yönlendirmekte iken genç hastada, özellikle de ailesel kardiyovasküler öyküsü yoksa ön tanı listemiz epey kabarık olmaktadır. Epidemiyoloji ve Etiyoloji Miyokardit sıklığının kadın ve erkek popülasyonda aynı olduğu biliyoruz. Eldeki verilere göre de ırk tercihi olmadığı düşünülüyor. Etyolojisini ise kabaca 3'e ayırmak mümkün: enfeksiyöz, immün aracılı ve toksik miyokardit. (Tablo 1'de tarihi anlamı olan geniş bir listeyi görebilirsiniz)​1​ Tablo 1 - Miyokardit Etyoloji Bilinen en sık neden enfeksiyonlar, en sık enfeksiyon nedeni de virüslerdir. Hatta hastaların %30'unda birden fazla viral etken olduğu görülür. Virüsler içerisinde adenovirüs ve enterovirüsler (koksaki A ve B, echovirüs) kardiyotropik olmaları ile öne çıkar. Lakin, Parvovirüs B19 (5. hastalık etkeni) ve HHV-6 (6. hastalık etkeni) son 20 yılda adenovirüs ve enterovirüslerden daha sık izole edilmiştir. HHV-6'nın lenfotropik virüs olması bu sıklığı açıklayabilir. Hayvan Modelinde Sınıflandırma Tablo 2- Fare modelinde miyokardit Bu hastalığın patofizyolojisi insan modelinde henüz açıklanamamıştır. Üstte yer alan şemada patofizyolojiyi güzel açıkladığını düşündüğüm fare modelinde yapılan bir araştırmadaki akışı sizlerle paylaşıyorum. Bu akış ve sonlanımlar insan sonlanımları ile de tutarlılık göstermekte.​1​ Bu çalışmaya göre, ilk 4 gün vireminin olduğu akut miyokardit, 4-14 gün viral temizlenmenin olduğu subakut miyokardit, 14 gün sonrası da viral temizlenmenin tamamen bittiği fibrozisle karakterize kronik miyokardit dönemidir. Akut miyokardit Viremi döneminde viral etken hücre içine girer. Bunu müteakip miyosit nekrozu ve makrofaj aktivasyonu başlar. Bunun sonucunda proinflamatuar sitokinler salgılanır. Bu dönem 3 şekilde sonlanır; hiçbir semptom olmaksızın iyileşebilirbu dönemi hafif semptomlar ile geçirip subakut miyokardite ilerleyebilir 3.ihtimal ve en can sıkıcı tablo olarak; ani kardiyak ölüm veya akut gelişen kalp yetmezliğine bağlı kardiyojenik şok ile sonlanabilir. Bu grup destek tedaviden yoksun kalırsa mortal seyreder. Subakut miyokardit Viral temizlenme döneminde aktörlerimiz artık proinflamatuvar sitokinlerin aktive ettiği natural killer hücreler ve lenfositlerdir, yani hücre aracılı yanıt vardır. Bunun için bu dönemdeki hastalar steroidden fayda görebilmektedir. Kronik miyokardit Akut miyokardit hastalarının %20-50 sinde kronik miyokardite ilerleme olur. Bu dönem kronik inflamasyonun ve fibrozisin hakim olduğu kardiyak dilatasyon ve kalp yetmezliğine ilerleyen bir süreçtir. Bu dönemdeki hastada dilate kardiyomiyopatiye bağlı semptomlar mevcuttur. Lieberman Sınıflandırması Hastalığın kliniğe ve süreye göre yapılan bir sınıflandırmasıdır. (Lieberman sınıflaması tablo 3)​1​ Bundan sonra hep bu sınıflama üzerinden konuşacağız: Tablo 3. Lieberman Sınıflaması Fulminan: hayvan modelindeki akut miyokarditin 2 ihtimalini kapsar; mortal seyreden ve asemptomatik iyileşen.Akut: hayvan modelindeki akut miyokarditten subakut miyokardite ilerleyenleri kapsar. Bu evredeki hastalar steroidden tek fayda gören gruptur.Kronik aktif: sol ventrikül disfonksiyonun eşlik ettiği idiyopatik dilate kardiyomiyopati ile sonuçlanır.

An interview with Dr. Loretta Nastoupil from MD Anderson Cancer Center, author on “Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: ASCO Guideline Update.” She discusses the identification, evaluation, and management of hematologic toxicities in patients receiving ICPis, including hemolytic anemia among others in Part 10 of this 13-part series. For more information visit www.asco.org/supportive-care-guidelines   TRANSCRIPT [MUSIC PLAYING] SPEAKER: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. BRITTANY HARVEY: Hello, and welcome to the ASCO Guidelines podcast series brought to you by the ASCO Podcast Network, a collection of nine programs covering a range of educational and scientific content and offering enriching insight into the world of cancer care. You can find all the shows, including this one, at ASCO.org/podcasts. My name is Brittany Harvey. And today, we're continuing our series on the management of immune-related adverse events. I am joined by Dr. Loretta Nastoupil from the University of Texas M.D. Anderson Cancer Center in Houston, Texas, author on Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy, ASCO Guideline Update, and Management of Immune-Related Adverse Events in Patients Treated With Chimeric Antigen Receptor T-Cell Therapy ASCO Guideline. And today, we're focusing on hematologic toxicities in patients treated with immune-checkpoint inhibitor therapy. Thank you for being here, Dr. Nastoupil. LORETTA NASTOUPIL: Thanks, Brittany. I'm happy to be here. BRITTANY HARVEY: Great. Then first I'd like to note that ASCO takes great care in the development of its guidelines and ensuring that the ASCO conflict of interest policy is followed for each guideline. The full conflict of interest information for this guideline panel is available online with the publication of the guidelines in the Journal of Clinical Oncology. Dr. Nastoupil, do you have any relevant disclosures that are related to these guidelines? LORETTA NASTOUPIL: Yes, Brittany. So I have received honorarium for participation in advisory boards from the following companies, including BMS/Celgene, Genentech, Janssen, Novartis, Merck, MorphoSys TG Therapeutics, and Takeda. And I've also received research funding support from BMS/Celgene, Gilead Kite, Genentech, Janssen, Novartis and Takeda. BRITTANY HARVEY: I thank you for those disclosures. Then let's get into what we're here today to talk about. So what are the immune-related hematologic toxicities addressed in this guideline? LORETTA NASTOUPIL: So it's important to recognize that hematologic toxicities that are immune-related as a result of immune therapy are infrequent occurrences. So it's important to recognize when they do occur and some of the unique workups given that they are so infrequent. So probably one of the most common is hemolytic anemia. It's important to recognize that these are cancer patients. And they may have multiple reasons for the development of acute or new onset anemia, but recognizing if they're on either checkpoint inhibitors or immune therapies, it's important to recognize that it might be spurred on as a result of immune-mediated anemia. We advise in terms of history and workup to consider whether or not they've been exposed to new drugs, whether or not they've had a recent insect or snakebite exposure. The recommended workup includes a CBC with also a peripheral blood smear to look for evidence of hemolysis or macroketosis. In addition, other hemolytic anemia workup includes evaluation for LDH, haptoglobin, reticulocyte count, bilirubin, and free hemoglobin. Other potential diagnoses on the differential include DIC, so a panel, including coags, PT, INR, and PTT, exploring autoimmune serologies, PNH screening, evaluation for infection such as viral or bacterial causes of hemolysis, and also consideration for bone marrow failure syndrome, including evaluation for potentially reversible causes, such as B12, folate, copper, parvovirus, iron, thyroid, infection, et cetera. G6PD level is helpful in the evaluation, as well as exploration as I mentioned of potentially new drugs that might be linked, including ribavirin, rifampin, dapsone, interferon, some of the antibiotics, such as cephalosporins, penicillins, NSAIDs, ciprofloxacin, for instance, et cetera. So as part of the workup, if we have excluded alternative causes and we think that the immune-checkpoint inhibitor might be the underlying cause of the autoimmune hemolytic anemia, then generally we will continue unless they have grade 2 or higher toxicity, which is generally a hemoglobin less than 10. In which case, we would recommend to hold the immune-checkpoint inhibitor, again, with significant anemia. So those with grade 2 or higher, you might consider initiating corticosteroids, including 1.5 to 1 milligram per kilogram per day until improvement. For grade 3 or higher-- so this is more severe anemia So hemoglobin is less than 8. Generally, we're recommending permanent discontinuation of the checkpoint inhibitor and potentially higher doses, including up to 2 milligrams per kilogram per day of prednisone or corticosteroid equivalent to speed up the recovery. In regards to transfusion requirements or consideration, we are suggesting you evaluate or consider your local or regional guidelines. We generally do not transfuse for a target hemoglobin greater than seven to eight. And we also recommend supplementation with folic acid. BRITTANY HARVEY: Great. And then beyond those recommendations for hemolytic anemia, what are the key recommendations for identification, evaluation, and management of acquired thrombotic thrombocytopenia purpura? LORETTA NASTOUPIL: Sure. So fortunately, TTP is quite rare, but, again, something that is worth exploring. Some of the challenges are in the clinical syndrome. And that it can mimic some of the other toxicities that are covered in other sections, particularly the neurotoxicity section. But essentially, for patients who have pretty dramatic change in platelet count, again, they may have additional clinical sequelae such as neurologic toxicity or adverse events. It's important to recognize that TTP might be an underlying cause, again, for patients who are on immune-checkpoint inhibitors. This is where a hematology consult early in the clinical course would be particularly of importance to recognize it and potentially to minimize offending agents. Drug exposure is always important, because many of these patients might have other drugs, in addition to their immune-checkpoint inhibitors, such as chemotherapy, sirolimus, tacrolimus, antibiotics et cetera. And so exploring offending agents is important. An ADAMTS13 level, an inhibitor titer, would be important to send if you're considering TTP, in addition to evaluating the peripheral smear, and the hemolytic anemia workup, as I just mentioned, including LDH, haptoglobin and reticulocyte count. Exploring infectious etiology, including CMV titers or serology, would be particularly helpful, an additional clinical evaluation, such as brain imaging with CT or MRI, echocardiogram, and EKG would be of help. For all grades of TTP, again, even with a clinical suspicion for the diagnosis, in addition to hematology consult, we recommend stabilizing the patient. That might require care in an acute care setting, making sure that they have adequate organ function and that this is stabilized. For grade 1 or higher, we recommend holding the immune-checkpoint inhibitor. And you might consider, again, initiation of corticosteroids with 0.5 to 1 milligram per kilogram per day of prednisone or an equivalent. For grade 3 or higher, we would, again, in addition to holding the checkpoint inhibitor and in conjunction with your hematology colleagues, you might initiate a therapeutic plasma exchange. Again, in accordance with existing guidelines, you may consider higher doses of steroids, including methylprednisolone 1 gram IV daily for three days. You could consider some additional supportive agents, such as rituximab or pembrolizumab if the ADAMTS13 level is less than 10 or less than 10% of normal and an inhibitor or elevated ADAMTS13 IgG has been detected. BRITTANY HARVEY: I appreciate you going through the details for TTP. So then, additionally, this guideline addresses aplastic anemia. So what are the key recommendations for identification, evaluation, and management of aplastic anemia? LORETTA NASTOUPIL: Yeah. So fortunately, again, these are quite rare situations. So with aplastic anemia, similar to what we've discussed in terms of workup of anemia, globally, it's important to explore potentially causes of, again, bone marrow failure syndrome. And aplastic anemia is one of those such causes. Exploration of a bone marrow biopsy in conjunction, again, with your hematology consult would be critically important, and exploring potentially reversible causes, again, such as deficiencies and important nutrients, viral etiologies, in addition to parvovirus, CMV, HHV-6 is important to consider and rule out. But I think the end of the day, a bone marrow biopsy and aspirate is going to be the most helpful assessment to ensure that aplastic anemia has been considered and worked up. In regards to management of aplastic anemia, we're going to hold the immune-checkpoint inhibitor. You may need to provide additional support such as growth factors. And close follow-up, I think is the most critical aspect of this. Sometimes we initiate patients on corticosteroids. We hold the checkpoint inhibitor. And then we may monitor them less frequently. Oftentimes, these patients with high malignancies are going to need to be followed very closely, sometimes weekly or multiple times a week. So in regards to management of aplastic anemia that might be immune mediated as a result of immune-checkpoint inhibitors and in conjunction with your hematology and colleagues, consideration of management might include administration of horse ATG and cyclosporine, but again transfusion support, growth factor support, even consideration for HLA typing and evaluation first. Stem cell transplantation might be appropriate, particularly for a young patient with minimal comorbidities. For grade 3 or higher, in addition to these considerations, we're going to hold the checkpoint inhibitor and monitor weekly for improvement. If no response, you might consider repeating immune suppression with Rabbit ATG plus cyclosporine or cyclophosphamide. And for refractory patients, consider eltrombopag plus best supportive care. BRITTANY HARVEY: Great. Thank you. Those are important notes on the management of aplastic anemia. So then, additionally, what are the key recommendations for the identification, evaluation, and management of lymphopenia? LORETTA NASTOUPIL: Yeah. I think one of the challenges with lymphopenia, it's common for patients who've had cancer-directed therapy, particularly things like chemotherapy. And so understanding whether or not this is a new onset after exposure to checkpoint inhibitors is one of the critical aspects, in addition to considering alternative causes. But for patients in which we do think the lymphopenia is a result of the immune-checkpoint inhibitor, we're not generally advising discontinuation or holding of the immune-checkpoint inhibitor, but it is important to consider best supportive measures, including whether or not patients might benefit from monitoring for reactivation of certain viral etiologies, including CMV and HHV-6, for instance, in addition to potential consideration for prophylactic strategies, such as PJP prophylaxis. Also, zoster reactivation might be something that these patients might indeed be at risk for. So as opposed to holding your checkpoint inhibitor and initiating things like corticosteroids, if we have excluded alternative causes and think lymphopenia is a result of the immune-checkpoint inhibitor or as immune mediated, ensuring that they are receiving best supportive care to mitigate some of their toxicity that may result as the result of the lymphopenia. BRITTANY HARVEY: Understood. And it's important to note for clinicians that management is different from a lot of the management of the other hematologic toxicities. So then the last hematologic toxicity that was addressed in this guideline was acquired hemophilia A. So what are those key recommendations? LORETTA NASTOUPIL: Acquired hemophilia A, again, fortunately is very rare and uncommon, but this is one situation where engagement of a hematologist, who is an expert in management of hemophilia, will be critical. So that would potentially be step one. In terms of laboratory assessment, that would be helpful, in addition to your CBC, where you're assessing things like platelet count, coagulation workup, including fibrinogen, PT, PTT, INR, that would be informative. Patients with acquired hemophilia A will likely have a prolonged activated PTT with a normal PT. So that might be one of the clues. Imaging would be helpful to ensure the patients don't have any signs of spontaneous bleeding or hematoma basis, such as MRI, CT, or ultrasound, if particularly they have any localizing symptoms. Medication review to look for alternative causes would always be helpful. And determination of the Bethesda unit level of inhibitor would be critical. In regards to management, we would hold the checkpoint inhibitor, initiate corticosteroids, transfusion support as indicated, and you want to treat the underlying acquired hemophilia with conjunction of a hematologist. For grade 2 or higher, this may require factor replacement. And the choice is usually based on the Bethesda unit of the titer. Administration of prednisone, in addition to rituximab 375 milligrams per meter squared weekly for four weeks or cyclophosphamide dosed at 1 to 2 milligrams per kilogram per day may be patient specific. And, again, that decision should be made in conjunction with your hematology consult. Prednisone, rituximab, and cyclophosphamide should be given for a minimum of five weeks. And factors should be prescribed to increase the level, particularly during bleeding episodes. And, again, the choice of the factor is based on the presence or absence of an inhibitor. For grade 3 or higher, we advise to permanently discontinue the immune-checkpoint inhibitor. These patients generally will be admitted for stabilization. They do require factor replacement. Bypassing agents may also be required, including factor VII. Caution should be taken in elderly patients and those with coronary artery disease. Corticosteroids, rituximab, and cyclophosphamide should also be considered, transfusion support, if they're having active bleeding. And if worsening or no improvement, you could consider adding cyclosporine or immune suppression to try and stabilize these patients. Again, acquired hemophilia A requires special clinical and laboratory expertise. This would require consult and potentially even transfer to a specialized center, and consultation with a hemophilia center should be initiated as soon as this is considered or confirmed. BRITTANY HARVEY: That's a great summary of these recommendations. The expert panel and you clearly put in a lot of work into these recommendations. So then in your view, how will these recommendations for the management of hematologic toxicities impact both clinicians and patients? LORETTA NASTOUPIL: I think the most important thing are disseminating this information. I think ASCO plays a critical role in helping clinicians first recognize some of the toxicities that are different from what we have traditionally seen with chemotherapy and may have different management strategies. So guidelines, such as this, are critically helpful. Podcasts, such as this, are incredibly helpful to get the information out, recognizing that all of us authors are more than willing to provide additional guidance and are willing to be contacted in this situation where someone's facing one of these unique and rare toxicities and would like some additional guidance in terms of further management. Hematologic toxicities are sometimes hard to distinguish or maybe potentially hard to recognize, given many of these patients may have been on prior chemotherapy agents, and anemia or thrombocytopenia may not be unusual, but recognizing if it's new or more severe than what has been seen previously and that, at least, consideration of an immune-mediated hematologic toxicity, be considered, because the management might be unique. And so I hope that we've outlined today some of the hematologic toxicities that are rare that may be seen with immune therapy and some of the strategies to work up alternative diagnoses and management if it is indeed immune-mediated toxicity. BRITTANY HARVEY: Definitely. And I really appreciate you going through these rare but very important toxicities. So thank you for your work on these guidelines and for taking the time to speak with me today, Dr. Nastoupil. LORETTA NASTOUPIL: Thanks, Brittany. BRITTANY HARVEY: And thank you to all of our listeners for tuning in to the ASCO Guidelines podcast series. Stay tuned for additional episodes on the management of immune-related adverse events. To read the full guideline, go to www.ASCO.org/supportive care guidlines. You can also find many of our guidelines and interactive resources in the free ASCO Guidelines app available in iTunes or the Google Play store. If you have enjoyed what you've heard today, please rate and review the podcast, and be sure to subscribe so you never miss an episode. [MUSIC PLAYING]

Episode 80 des Walk-Män-Podcasts: Almut Boller und die KurVISION. Die Geschäftsführerin des Hessischen Heilbäderverbandes HHV erläutert in dieser Episode, was sie und ihre Kollegen sich von einer erstmaligen Definition des Begriffes Kur versprechen. Außerdem erfahren die HörerInnen in diesem Gespräch zwischen Almut Boller und Podcaster Ralf Baumgarten, welche neuen Projekte sich die Heilbäderfamilie dafür ausgesucht hat und woher der Wiesbaden seinen Namen hat.Ein lockeres Gespräch, das ein bißchen Licht am Ende eines langen und dunklen Tunnels erkennen lässt. Und wer sich noch etwas tiefer mit den Existenzproblemen der Heilbäder und Kurorte in Hessen (und den anderen deutschen Bundesländern) befassen möchte, dem sind die früheren – aber immer noch aktuellen – Episoden zu diesem Thema ans Herz gelegt:(Weitere) Walk-Män-Podcast CLASSICS zu den Themen Heilbäderverband und Kurwesen:14. Walk-Män: Im Gespräch mit HHV-Geschäftsführerin Almut Boller19. Walk-Män: Pressekonferenz: Kurorte in der "schlimmsten Krise"39. Walk-Män: Die Rückkehr der Kur, Teil 1 - mit Almut Boller (HHV)40. Walk-Män: Die Rückkehr der Kur, Teil 2 - mit Dieter Adt (DEHOGA)Kontakt Hessischer Heilbäderverband HHV: www.hessische-heilbaeder.deKontakt Hessischer Heilbäderverband HHV auf Facebook:www.facebook.com/HeilbaederTitelbild dieser Episode: Agentur Fouad-Vollmer für die Heilbäder & Kurorte in HessenNäheres zu den Walk-Män-Projekten und zum Podcast auf der Walkmän-Homepage (siehe unten) – oder dirtekt über mich (Ralf Baumgarten) direkt.In diesem Sinne: Viel Spaß und gute Unterhaltung, ich danke Euch für Eure Aufmerksamkeit.Kontakt: Ralf Baumgarten / Walk-Män:Mobil: 0172 6612032Homepages: https://walkmaen.de/ https://mein-blaettche.deMail: walkmaenpodcast@gmail.comFacebook: https://www.facebook.com/walkmaenorbWenn Dir gefällt, was Du hörst, dann abonniere den Podcast bei ITunes, Spotify, Deezer, Amazon-Music, Google-Podcast und überall, wo es Podcasts zu hören gibt.Bleib wach, gesund und aufmerksam, Dein Ralf (Baumgarten)

Episode 80 des Walk-Män-Podcasts: Almut Boller und die KurVISION. Die Geschäftsführerin des Hessischen Heilbäderverbandes HHV erläutert in dieser Episode, was sie und ihre Kollegen sich von einer erstmaligen Definition des Begriffes Kur versprechen. Außerdem erfahren die HörerInnen in diesem Gespräch zwischen Almut Boller und Podcaster Ralf Baumgarten, welche neuen Projekte sich die Heilbäderfamilie dafür ausgesucht hat und woher der Wiesbaden seinen Namen hat. Ein lockeres Gespräch, das ein bißchen Licht am Ende eines langen und dunklen Tunnels erkennen lässt. Und wer sich noch etwas tiefer mit den Existenzproblemen der Heilbäder und Kurorte in Hessen (und den anderen deutschen Bundesländern) befassen möchte, dem sind die früheren – aber immer noch aktuellen – Episoden zu diesem Thema ans Herz gelegt: (Weitere) Walk-Män-Podcast CLASSICS zu den Themen Heilbäderverband und Kurwesen: 14. Walk-Män: Im Gespräch mit HHV-Geschäftsführerin Almut Boller 19. Walk-Män: Pressekonferenz: Kurorte in der "schlimmsten Krise" 39. Walk-Män: Die Rückkehr der Kur, Teil 1 - mit Almut Boller (HHV) 40. Walk-Män: Die Rückkehr der Kur, Teil 2 - mit Dieter Adt (DEHOGA) Kontakt Hessischer Heilbäderverband HHV: www.hessische-heilbaeder.de Kontakt Hessischer Heilbäderverband HHV auf Facebook:www.facebook.com/Heilbaeder Titelbild dieser Episode: Agentur Fouad-Vollmer für die Heilbäder & Kurorte in Hessen Näheres zu den Walk-Män-Projekten und zum Podcast auf der Walkmän-Homepage (siehe unten) – oder dirtekt über mich (Ralf Baumgarten) direkt. In diesem Sinne: Viel Spaß und gute Unterhaltung, ich danke Euch für Eure Aufmerksamkeit. Kontakt: Ralf Baumgarten / Walk-Män: Mobil: 0172 6612032 Homepages: https://walkmaen.de/ https://mein-blaettche.de Mail: walkmaenpodcast@gmail.com Facebook: https://www.facebook.com/walkmaenorb Wenn Dir gefällt, was Du hörst, dann abonniere den Podcast bei ITunes, Spotify, Deezer, Amazon-Music, Google-Podcast und überall, wo es Podcasts zu hören gibt. Bleib wach, gesund und aufmerksam, Dein Ralf (Baumgarten)

Everyday Protector AndrewAnother great chat with an everyday protector, those on the line right now, working on that thin line. Andrew joined me to talk about police life and importance of training. Andrew also talks about using his creative outlet of designing and making custom knives to destress. @hard_head_veterans @standwatchknivesHard Head Veterans offers a $15 discount, use code: protectorThis series is a partnership with Hard Head Veterans. Why did I team up with HHV? Well, as my friend would say, your body is holding up a soft-boiled egg, not a lot of protection from falls or bullets. Got a helmet available? On the job? Use it.From the HHV Site: Tactical Helmets Are What We Do! Here's the deal, Hard Head Veterans is a veteran owned and operated small business selling tactical ballistic helmets like MICH helmets to the men and women who need them the most. We are veterans of the United States' most current conflicts, and many of us continue to serve our country today through reserve or contracting roles. Every single member of our team is connected to the military or law enforcement, making us uniquely qualified to better understand and serve the needs of our customersSupport the show (https://www.patreon.com/theprotectors)

Matt Thomas, Chief Deputy to Sheriff Lamb, joined The Protectors to talk about his time on the job, the importance of training, the changing culture of policing, and a ton of other topics. Make sure to tune in to your favorite podcast platform (search Protectors with Jason Piccolo). @deputy_onetimeThis series is a partnership with Hard Head Veterans. Why did I team up with HHV? Well, as my friend would say, your body is holding up a soft-boiled egg, not a lot of protection from falls or bullets. Got a helmet available? On the job? Use it.From the HHV Site: Tactical Helmets Are What We Do! Here's the deal, Hard Head Veterans is a veteran-owned and operated small business selling tactical ballistic helmets like MICH helmets to the men and women who need them the most. We are veterans of the United States' most current conflicts, and many of us continue to serve our country today through the reserve or contracting roles. Every single member of our team is connected to the military or law enforcement, making us uniquely qualified to better understand and serve the needs of our customers.@hard_head_veterans #hardheadveterans #ballistic #ballistichelmets #protector #everydayprotector #theprotectors #americansheriff @americansheriff @americansheriffnetworkSupport the show (https://www.patreon.com/theprotectors)

Contributor: Peter Bakes , MD Educational Pearls: Pediatric Fever + Rash Differential: scarlet fever, measles, rubella, chicken pox, fifth’s disease, HHV-6, adenovirus, anaphylaxis, Kawasaki’s disease Kawasaki’s is diagnosed clinically with prolonged fever (>7 days fever in 5 days of fever >6 months with 4 of the following:  Strawberry tongue/fissured lips Bilateral conjunctival injection Cervical lymphadenopathy Hand/foot edema Maculopapular rash Can develop life threatening coronary artery aneurysms Treated with aspirin/IVIG References Modesti AM, Plewa MC. Kawasaki Disease. [Updated 2020 Jul 2]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK537163/?report=classic Ramphul K, Mejias SG. Kawasaki disease: a comprehensive review. Arch Med Sci Atheroscler Dis. 2018;3:e41-e45. Published 2018 Mar 21. doi:10.5114/amsad.2018.74522 Summarized by John Spartz, MS3 | Edited by Erik Verzemnieks, MD  

Episode 39: Dürfen die Sektkorken knallen? Die Kur- und Heilbäder nicht nur in Hessen sehen seit Dezember des Vorjahres der lange ersehnten Rückkehr der Kur entgegen. Das kann für diese Orte, Kliniken, Handel und Gastronomie nach Corona mehr sein, als nur ein Silberstreif am Horizont. Was genau ist geschehen: Ambulante und stationäre Vorsorgeleistungen in den Heilbädern und Kurorten werden wahrscheinlich zum Sommer 2021 Pflichtleistungen der Krankenkassen. Darüber und über die sich dadurch eröffnenden flächendeckenden Chancen für Kur und Touristik in deutschen Landen unterhalte ich mich mit der HHV-Geschäftsführerin Almut Boller. Im zweiten Teil dieser Doppelfolge (erscheint einen Tag später) spreche ich mit dem DEHOGA-(Main-Kinzig-)Chef Dieter Adt über die "Tourismuspolitischen Gedanken", die das Ziel verfolgen, den Tourismus zu stärken, Arbeitsplätze zu sichern und Lebensqualität zu sichern. Viel Spaß und gute Unterhaltung - über Feedback würde ich mich freuen. Zum Thema: Ein Silberstreif am Horizont in coronagetrübten Zeiten für die Heilbäder und Kurorte in Hessen ist das Gesetz zur Weiter-entwicklung der Gesundheitsversorgung. Denn das im Dezember 2020 im Deutschen Bundestag beschlossene Gesetz sieht vor, dass die ambulanten und stationären Vorsorgeleistungen in anerkannten Kurorten von Ermessens- in Pflichtleistungen der Krankenkassen umgewandelt werden. Damit erfüllt sich eine Forderung des Deutschen Heilbäderverbandes, die der Branchenverband gemeinsam mit den Heilbäderverbänden der Bundesländer formuliert hat. „Diese Gesetzesänderung ist eine herausragende Chance für die Heilbäder und Kurorte in ganz Deutschland“, freut sich der Vorsitzende des Hessischen Heilbäderverbandes, Bürgermeister Michael Köhler, Bad Zwesten, über das Gesetz zur Weiterentwicklung der Gesundheitsversorgung. „Damit können die vielgestaltigen Angebote der prädikatisierten Orte endlich wieder ihre volle Wirkkraft entfalten.“ „Gesundheit ist des Menschen höchstes Gut,“ macht dazu die Geschäftsführerin des Hessischen Heilbäderverbandes, Almut Boller deutlich. „Die Heilbäder und Kurorte in Hessen bieten mit ihren kurspezifischen Einrichtungen beste Voraussetzungen für ambulante und stationäre Vorsorgemaßnahmen. Damit können sie zu einem langen und unbeschwerten Leben der Gäste und besonders auch der Bürgerinnen und Bürger beitragen. Gerade die Heilbäder und Kurorte in Hessen sind, wenn voraussichtlich im Sommer 2021 das Gesetz in Kraft tritt, für die neue Entwicklung sehr gut aufgestellt. Denn sie haben sich bereits inhaltlich und strategisch neu ausgerichtet. Kern des Richtungswechsels ist die Marke DIE KUR, die der Hessische Heilbäderverband neu begründet hat und die zukünftig noch stärker im Markt platziert wird. Der tradierte Begriff „Kur“ wird inhaltlich modern ausgestaltet, in den Kurorten authentisch erlebbar und zeitgemäß präsentiert. Wichtige Bestandteile der Angebote sind die natürlichen Heilmittel und die staatlich anerkannte Qualität, die im Prädikat „Heilbad“ oder „Kurort“ sichtbar wird.“ Bilder: Hessischer Heilbäderverband HHV und Privatarchiv Ziegler/Eisentraud Bad Orb Shownotes: https://www.hessische-heilbaeder.de/ Werbung / Diese Episode des Walk-Män-Podcasts wird unterstützt von: "Zinzino" – Stärken Sie Ihren Körper von Innen. Erhöhen Sie den Omega-3-Wert Ihres Körpers und schützen Sie Ihre Zellen vor der Oxidation. Was ist Zinzino und was steckt dahinter? Mehr auf: https://www.zinzino.com/2008533592/DE/de-DE Kontakt Ralf Baumgarten / Walk-Män: https://walkmaen.de/ walkmaenpodcast@gmail.com Facebook = https://www.facebook.com/walkmaenorb Wenn Dir gefällt, was Du hörst, dann abonniere den Podcast bei ITunes, Spotify, Deezer, Amazon-Music, Google-Podcast und überall, wo es Podcasts zu hören gibt. Bleib wach, gesund und aufmerksam, Dein Ralf Baumgarten

Medication-induced drug disorders have been evident for nearly a century and labeled with a variety of names. French dermatologist Dr. Vincent Descamps, who has been at the forefront of DRESS syndrome since the mid-1990s, joins us to review this historically misunderstood and under-reported illness. We'll also discuss the history of how an international team of researchers and physicians identified the clinical condition known as DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms). Interview: Dr. Vincent Descamps (Professor of Dermatology at the Bichat Claude Bernard Hospital, University Denis Diderot in Paris, France) June, 2019 in Quebec, Canada.PUBLICATIONS/RESOURCES:DRESS syndrome: https://docs.wixstatic.com/ugd/cac731_643993b7381f4c85b7d4b62dce42087b.pdfDiagnosis of DRESS (Drug Reaction With Eosinophilia and Systemic Symptoms) in the Intensive Care Unit: Essential But Challenging: https://journals.lww.com/shockjournal/Fulltext/2013/11000/Diagnosis_of_DRESS__Drug_Reaction_With.14.aspxFrench dermatologists call for antiviral therapy in DRESS: https://hhv-6foundation.org/drug-hypersensitivity/french-dermatologists-call-for-antiviral-therapy-in-dressSaliva polymerase chain reaction assay for detection and follow-up of herpesvirus reactivation in patients with drug reaction with eosinophilia and systemic symptoms (DRESS): https://pubmed.ncbi.nlm.nih.gov/23426332/Drug rash with eosinophilia and systemic symptoms (DRESS) in patients receiving strontium ranelatez: https://pubmed.ncbi.nlm.nih.gov/23361875/Human herpesvirus 6 involvement in paediatric drug hypersensitivity syndrome: https://onlinelibrary.wiley.com/doi/abs/10.1111/bjd.13592The DRESS Syndrome: A Literature Review: https://www.amjmed.com/article/S0002-9343(11)00258-0/fulltextChapter 11 - HHV-6A and HHV-6B in Drug-Induced Hypersensitivity Syndrome/Drug Reaction with Eosinophilia and Systemic Symptoms: https://www.sciencedirect.com/science/article/pii/B9780444627032000112Service de Dermatologie/Hôpital Bichat - Claude-Bernard: https://www.aphp.fr/service/service-16-011Chronic persistent HHV‐6B infection after sulfasalazine‐induced DRESS with demonstration of HHV‐6 encoded small noncoding RNAs (sncRNAs) in Crohn's‐like colitis: Case report: https://onlinelibrary.wiley.com/doi/10.1002/ccr3.3680#.X90Agxjv1sI.twitter

International severe adverse drug reaction experts, Dr. David Ostrov and Dr. Vincent Descamps, talk to us about the immune response that occurs in DRESS syndrome as well as how antiviral and steroid therapies are often indicated in fighting this condition. We also hear from Kent Van Donge about the importance of a team approach in the treatment of DRESS.Interview: Dr.David A.Ostrov (Associate Professor of Experimental Pathology/University of Florida), Dr. Vincent Descamps (Professor of Dermatology at Bichat Claude Bernard Hospital), Kent Van Donge (Intern/Student and EMT) at the HHV-6 Foundation 2019 Conference in Quebec, Canada.PUBLICATIONS/RESOURCES:Dr. David Ostrov: David A. Ostrov Laboratory: https://ostrovlab.pathology.ufl.edu/about-dr-ostrov/The structural basis of HLA-associated drug hypersensitivity syndromes: https://onlinelibrary.wiley.com/doi/10.1002/ccr3.3680#.X90Agxjv1sI.twitterDrug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire:https://www.pnas.org/content/109/25/9959.longFull List of Publications: https://ostrovlab.pathology.ufl.edu/about-dr-ostrov/select-publications/full-list-of-publications/Dr. Vincent Descamps:DRESS syndrome:https://docs.wixstatic.com/ugd/cac731_643993b7381f4c85b7d4b62dce42087b.pdfDiagnosis of DRESS (Drug Reaction With Eosinophilia and Systemic Symptoms) in the Intensive Care Unit: Essential But Challenging: https://journals.lww.com/shockjournal/Fulltext/2013/11000/Diagnosis_of_DRESS__Drug_Reaction_With.14.aspxFrench dermatologists call for antiviral therapy in DRESS:https://hhv-6foundation.org/drug-hypersensitivity/french-dermatologists-call-for-antiviral-therapy-in-dressSaliva polymerase chain reaction assay for detection and follow-up of herpesvirus reactivation in patients with drug reaction with eosinophilia and systemic symptoms (DRESS): https://pubmed.ncbi.nlm.nih.gov/23426332/Drug rash with eosinophilia and systemic symptoms (DRESS) in patients receiving strontium ranelatez: https://pubmed.ncbi.nlm.nih.gov/23361875/Human herpesvirus 6 involvement in paediatric drug hypersensitivity syndrome: https://onlinelibrary.wiley.com/doi/abs/10.1111/bjd.13592The DRESS Syndrome: A Literature Review: https://www.amjmed.com/article/S0002-9343(11)00258-0/fulltextService de Dermatologie/Hôpital Bichat - Claude-Bernard:https://www.aphp.fr/service/service-16-011Chronic persistent HHV‐6B infection after sulfasalazine‐induced DRESS with demonstration of HHV‐6 encoded small noncoding RNAs (sncRNAs) in Crohn's-like colitis. Case report:https://onlinelibrary.wiley.com/doi/full/10.1002/ccr3.3680?af=R

German virologist, Dr. Bhupesh Prusty, discusses his research on the human herpes virus, HHV-6, and its important role in many medical conditions including DRESS syndrome. We then hear from Japanese dermatologist and DRESS expert, Dr. Hideo Asada, about the long-term complications associated with HHV-6 and DRESS.Interview: Dr. Bhupesh Prusty (Molecular virologist University of Wuerberg, Germany), Dr. Hideo Asada (Professor, Researcher at the Department of Dermatology Nara Medical University in Japan), June, 2019 in Quebec, CanadaPUBLICATIONS/RESOURCES:Dr. Bhupesh Prusty:Chronic persistent HHV‐6B infection after sulfasalazine‐induced DRESS with demonstration of HHV‐6 encoded small noncoding RNAs (sncRNAs) in Crohn's‐like colitis: Case report: https://onlinelibrary.wiley.com/doi/full/10.1002/ccr3.3680?af=RHHV-6 encoded small non-coding RNAs define an intermediate and early stage in viral reactivation: https://www.nature.com/articles/s41525-018-0064-5Additional Publications/Researchgate: https://www.researchgate.net/profile/Bhupesh-PrustyDr. Hideo Asada:Dynamics of chemokines in severe drug hypersensitivity: https://ctajournal.biomedcentral.com/articles/10.1186/2045-7022-4-S3-P29Parallel changes in serum thymus and activation‐regulated chemokine levels in response to flare‐ups in drug‐induced hypersensitivity syndrome: https://onlinelibrary.wiley.com/doi/pdf/10.1111/1346-8138.15548Preferential expression of CD134, an HHV-6 cellular receptor, on CD4T cells in drug-induced hypersensitivity syndrome (DIHS)/drug reaction with eosinophilia and systemic symptoms (DRESS): https://hhv-6foundation.org/transplant-complications/cd134-upregulation-may-explain-why-hhv-6-reactivates-preferentially-in-dressFacial pustules due to drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms may histopathologically mimic eosinophilic pustular folliculitis: A case report: https://pubmed.ncbi.nlm.nih.gov/30666704/Sequelae in 145 patients with drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms: survey conducted by the Asian Research Committee on Severe Cutaneous Adverse Reactions (ASCAR): https://pubmed.ncbi.nlm.nih.gov/25623158/Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms or non-drug-related erythroderma with a persistent human herpesvirus 6 infection: https://doi.org/10.1111/1346-8138.15145

Viruses from previous infection may stay dormant in our bodies for years - sleeping away the time, never causing any trouble. However, in immunosuppressed conditions like DRESS, the virus may awaken and wreak havoc. Viral reactivation of  human herpesviruses, in particular HHV-6, are a known phenomenon of DRESS, occurring in up to 50% of patients. While the exact role of HHV-6 reactivation in DRESS has been a controversial topic, many experts believe that it is not taken seriously enough.Co-founder, president and executive director of the HHV-6 Foundation, Kristin Loomis discusses the importance of identifying HHV-6 viral reactivation  in DRESS syndrome and the existing roadblocks to treating infected patients with antiviral medication. Interview: Kristin Loomis (Founder and Executive Director of the HHV-6 Foundation), June, 2019 in Quebec, Canadahttps://hhv-6foundation.orghttps://hhv-6foundation.org/category/drug-hypersensitivity

Did we take it too far this week? Maybe. Did we flaunt our exorbitant level of scumbaggery? Probably. Did we make you laugh at our distasteful jokes and now you realize you’re no better than us? Absolutely. Welcome to the HHV club, fellow douchebags!

Episode 19: Die hessischen Heilbäder haben Sorgen. 27 Millionen Euro fehlen aktuell in den Kassen, Hilfe von Land und Bund ist dringend notwendig, um den Erhalt der Kurorte und Heilbäder zu sichern, viele tausend Arbeitsplätze zu sichern und eine Landflucht zu verhindern - zwei Drittel der Kurorte liegen in ländlichen Regionen, sind mono-strukturiert. In einer Pressekonferenz in Bad Soden-Salmünster stellte sich der Vorstand des Heilbäderverbandes HHV den Journalisten und legte die Karten auf den Tisch. Mit dabei waren: Almut Boller, Geschäftsführerin des Hessischen Heilbäderverbandes e.V. Kurdirektor Stefan Ziegler, Bad Soden-Salmünster Michael Köhler, Vorsitzender des Hessischen Heilbäderverbandes Kurdirektor Holger Reuter, Bad Homburg sowie als Vertreterin einer ortsansässigen Klinik: Claudia Kugler, Pflegeleitung St- Marien-Klinik Bad Soden-Salmünster Shownotes: https://www.hessische-heilbaeder.de/ https://www.bad-orb.info/media/attraktionen/tourist-information https://www.badsoden-salmuenster.de/tourismus/touristinformation.html https://www.bad-salzschlirf.de/ https://www.bad-homburg.de/ https://www.reha-hospital.de/hessen/klinik-st.-marien.html Kontakt Ralf Baumgarten / Walkmän: http://walkmaen.de/ walkmaenpodcast@gmail.com Facebook = https://www.facebook.com/walkmaenorb Wenn Dir gefällt, was Du hörst, dann abonniere den Podcast bei Apple-Podcast, Spotify, Deezer, Google-Podcast und überall, wo es Podcasts zu hören gibt. Bleib wach, gesund und aufmerksam, Dein Ralf Baumgarten

Human herpes virus 8 (HHV-8) or Kaposi sarcoma associated herpes virus is the cause of all forms of Kaposi sarcoma. Kaposi sarcoma occurs primarily in homosexual men with HIV infection as an AIDS defining illness and can complicate immunosuppressive therapy. Improvement is often seen after the immunosuppression is stopped. The patient will typically present with red or purple plaques or nodules on cutaneous or mucosal surfaces. Marked edema can occur with few or no skin lesions. Kaposi sarcoma commonly involves the GI tract and can be screened with fecal occult blood testing. In asymptomatic patients, these lesions are not sought or treated. Pulmonary Kaposi sarcoma, which can be asymptomatic and appear only on chest radiography, can present with shortness of breath, cough, hemoptysis, or chest pain. Chronic Kaposi sarcoma can develop in patients with HIV infection, high CD4 counts, and low viral loads. Here, the Kaposi sarcoma is in its endemic form and is indolent as well as localized. The sarcoma can be clinically aggressive, though. The presence of Kaposi sarcoma at the time of antiretroviral initiation is associated with Kaposi sarcoma-immune reconstitution inflammatory syndrome which has an especially aggressive course in patients with visceral disease. As far as treatment is concerned, in more seasoned patients, palliative local therapy with intralesional chemotherapy or radiation is usually all that is required. If the patient has iatrogenic immunosuppression, treatment consists of reduced doses of immunosuppressive medications. On the other hand, if the patient has AIDS associated Kaposi sarcoma, she or he should be given ART. Other therapeutic options include cryotherapy or intralesional vinblastine (0.1-0.5 mg/mL) for cosmetically objectionable lesions; radiation therapy for accessible and space occupying lesions; and laser surgery for certain intraoral and pharyngeal lesions. Systemic therapy is indicated in patients with rapidly progressive skin disease, edema or pain, and symptomatic visceral disease or pulmonary disease. Liposomal doxorubicin is highly effective in severe cases and may be used alone or in combination with bleomycin and vincristine. Paclitaxel and other taxanes can be effective even in patients who do not respond to anthracycline treatment. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app

Human herpesvirus 6 or HHV-6, is a herpes virus just like Epstein-Barr Virus, Cytomegalovirus, Chicken pox (varicella zoster), HHV-7, HHV-8 and Herpes simplex 1 and 2.  There are two types of this virus including HHV-6A and HHV-6B. 100% of human beings get infected with HHV-6B by the age of three which results in fever, diarrhea and a rash called roseola. In rare cases it can cause seizures and encephalitis.  There are many infection connections to autoimmune diseases like Hashimoto's disease and in this article I'll cover the connection between HHV-6 and Hashimoto's disease. Less is known about HHV-6A which was found in a small study in 50% of adults.  HHV-6A is said to be the most problematic of the two types and it is the type found inside the thyroid glands of some people with Hashimoto’s thyroiditis. Just like other herpes viruses, HHV-6 can reactivate (occurs in the thyroid gland, GI tract, brain, heart, kidneys, uterus, and lungs) later in life when the immune system is compromised resulting in a variety of conditions including: Hashimoto’s thyroiditis Sjogren's syndrome Lupus Rheumatoid arthritis Sarcoidosis Guillan-Barre Multiple Sclerosis Infertility Chronic fatigue syndrome Fibromyalgia HIV progression to AIDS Epilepsy Seizures Immune suppression Certain types of cancer Kidney, liver, lung disease Heart disease Encephalitis Colitis Transplant recipient issues Bone marrow suppression Autoimmune hepatitis What is the link between HHV-6 and Hashimoto’s disease? Here are some studies supporting the connection between HHV-6 and Hashimoto's disease: Rizzo et al. in 2016 found a direct connection among natural killer cell activation, thyroid antibodies, and HHV-6 in patients with Hashimoto's disease.  This study found that the HHV-6 virus causes an increase in natural killer cells against the virus which causes an ongoing inflammatory process in the thyroid gland that correlates with thyroid peroxidase and anti-thyroglobulin antibodies.  This means that an active HHV-6 infection in the thyroid gland drives the elevation of thyroid antibodies and increases inflammation in the gland resulting in increased damage to thyroid tissue. A study published in 2012 entitled "Virologic and Immunologic Evidence Supporting an Association between HHV-6 and Hashimoto's Thyroiditis" by Caselli et al. found that a high percentage of patients in the study with Hashimoto’s disease have active HHV-6A infections inside the thyroid gland.  This increases inflammation in the thyroid gland since the immune system is concerned about Human herpesvirus 6 and due to antibodies against the thyroid gland. A follow-up study by Caselli et al. in 2017 entitled "HHV-6A in vitro infection of thyrocytes and T cells alters the expression of miRNA associated to autoimmune thyroiditis" also found a connection between HHV-6 and Hashimoto's disease. Sultanova et al. in their 2017 paper entitled "Association of active human herpesvirus-6 (HHV-6) infection with autoimmune thyroid gland diseases" found a statistically significant higher level of persistent HHV-6 infection in those with Hashimoto's disease compared to the control group.  They also biopsied thyroid tissue of patients with Hashimoto's disease compared to a control group without Hashimoto's disease, and they found a statistically significant higher level of HHV-6 in those with Hashimoto's disease compared to the control group (18/44 (41%) vs. 1/17 (6%)). Seyyedi et al. in their 2019 paper entitled "Human herpesvirus 6A active infection in patients with autoimmune Hashimoto's thyroiditis" consisting of 242 patients found 57 out of 151 (38%) of patients with Hashimoto's disease had active HHV-6A infections.  5 out of 59 (8%) patients with non-autoimmune thyroid disorders had active HHV-6A infections.  And 0 out of 32 (0%) patients with normal thyroid function had active HHV-6A infections. Why does it reactivate in some people?

Dressies! Wir haben uns mit unserem Freund POWL aka Mr. Knight aka Das Großmaul über die Wichtigkeit von drei Paar Tiffany Dunks, Trash-TV, Rassismus in der Lada-Community und Gewalt auf Hip Hop Jams unterhalten. Als wäre das nicht genug, erörterten wir auch noch Rap-Dokus auf Netflix für HHV. Horchet auf!

Kulturarv i oversvømmelsesfare: Vand, vand og mere vand. Februar har sat regn-rekord, DMI varsler, at der er mere hvor det kommer fra, og oversvømmelserne truer store værdier, både materielle og kulturelle. Kulturen på P1 tager et kig landet rundt for at se, hvor kulturarven er truet af regngudens gavmildhed. Et dødsknald med konsekvenser: Den unge antropologistuderende Anita rejser ind i Perus jungle, og så sker der ting og sager. Også flere end forfatteren til historien, Hanne Højgaard Viemose, selv var klar over, da hun begyndte at skrive. Nu har romanen "HHV, Frshwn, Dødsknaldet i Amazonas" indbragt hende en nominering til Nordens største litteraturpris. Hanne Højgaard Viemose er portrætgæst i Kulturen på P1. Stor musik i små lokaler: Koncerter behøver ikke foregå i store sale med fantastisk akustik eller på festivalscenerne: Hvad med en privat lejlighed på femte sal? Kulturen på P1 hopper på en ny trend og besøger et koncertsted i mini-format. Fra krig til fredelig fred: Igen og igen har Danmark haft militære konflikter med den store nabo mod syd. Alligevel er den dansk-tyske grænse i dag så fredelig, at den er indstillet til UNESCO-kulturarv. I 100-året for genforeningen med Sønderjylland er Kulturen på P1 draget til grænselandet for at nærstudere idyllen - og sprækkerne i den. Værter: Karen Secher og Jesper Dein.

Abbiamo conosciuto Wuf tramite Carlo (Fight Pausa, 72–Hour Post Fight), amico e collaboratore di questo giovane beatmaker lo-fi con base a Legnano. È una di quelle tipiche figure misteriose che producono rimanendo fuori dai riflettori, limitando la propria presenza sui social e lasciando parlare solo la propria musica. All’attivo Wuf ha già diversi ep e collaborazioni con etichette europee: HHV Records, Vinyl Digital, Urban Waves e Autumn Theory Records, ma è con HHV in particolare che esce il suo primo LP in vinile, nel 2015, e il suo ultimo lavoro Interface, uscito da poche settimane per l’etichetta berlinese. La sua conoscenza musicale si estende oltre i confini dell’hip hop e si sviluppa nei territori jazz, soul, r’n’b e di tutta la black music in generale, ma non solo: in questo Weekend Mixtape ci sono anche alcune gemme impolverate di library music italiana e soundtrack giapponesi. Insomma: quanta knowledge in questa tracklist. @xyzwuf Read more: https://www.ptwschool.com/blog/weekend-mixtape-70-wuf.html

If you don’t have herpes then hearing that everyone has  herpes virus probably just freaked you out! Well, it’s true that everyone has a herpes virus and it’s nothing to be worried about. You’re going to be just fine. Promise.  We’ve been living with these dang herpes viruses for as long as humans have been walking on this earth. The herpes virus want to survive as much as we do and they’ve done a pretty good job at it.  Let me explain.   There are more than 100 known herpes viruses out there! Yep 100! The good news is that there are really only 8 that infects us as humans. Here’s the list and I’d bet you have more than one of them: herpes simplex virus type 1 (HSV) or commonly known as cold sores or fever blisters herpes simplex virus type  2 (HSV) commonly known as genital herpes Varicella-zoster virus (VZV) or commonly known as chickenpox or shingles cytomegalovirus is very common and doesn’t really have any symptoms Epstein-Barr virus or commonly known as mononucleosis or mono and the Symptoms include fatigue, fever, rash, and swollen glands.  human herpesvirus 6 or commonly known as HHV and infects nearly 100% of human beings, typically before the age of three and often results in fever, diarrhea, sometimes with a rash known as roseola. human herpesvirus 7 or commonly known as HHV has symptoms including acute febrile respiratory disease, fever, rash, vomiting, diarrhea, low lymphocyte counts, and febrile seizures, though most often no symptoms present at all. Kaposi's sarcoma virus or human herpesvirus 8 include symptoms that are lesions on the skin: flat, painless spots that are red or purple on white skin and bluish, brownish, or black on dark skin.    Ok so heres the deal. You have 1 or 2 or 3 or many of the herpes virus that are living with us humans. The only one that causes us to freak out or make us believe that we did something wrong is herpes or HSV 1 or 2. So why is it that getting chicken pox or mono doesn’t make us feel like we’re a leper? My guess it’s all a marketing stunt that was put into place to sell the antiviral, valtrex. The pharma companies need a compelling story to convince people that then needed this antiviral in order to continue to live a normal life. And yes, it’s 100% BS. You don’t need the antiviral to live a normal life, yes it helps heal the outbreaks faster but thats really it.    But back to the 8 herpes viruses and how we all have many of them and we all freak out about getting genital herpes or oral herpes.  It really does get me going when you hear people cringe or have an eww attitude towards people with herpes when I know that they have herpes viruses too. Oh and 80% of the people with HSV don’t even know they have it.    The reason why this is important to you, someone living with either oral or genital herpes, is that you can educate the person who stereotypes you or calls you names. Ask them if they have ever had mono or the chicken pox or cold sores. I can guarantee you they’ve had one or all of them.    The truth is you have herpes viruses and that’s just fine. Chickenpox or mono doesn’t define you’re life so why should you let HSV 1 or 2 define your life. What? It’s because you feel like nobody else has it or nobody will date you? It’s total BS and all that it is is a stupid virus that gives you some blisters here and there. That’s it! Life With Herpes Details: Join the Secret Society  HerpAlert (use promo code: lifewithherpes and get 10% off) Shop the LWH Essentials Shop the Secret Society CBD Lip Balm  Oh yea, remember to subscribe to the Life With Herpes newsletter and get The 5 things  I wished she knew before I was diagnosed with herpes sent directly to your inbox + weekly updates.    Xoxo, Alexandra Just in case… Learn about the Herpes Outbreak Toolkit: Need to talk confidentially about herpes?  Oh Yea and in case you need Herpes Outbreak Essentials   Are you social?  Instagram Facebook  

We're all over PANS/PANDAS (Pediatric Acute-onset Neuropsychiatric Syndrome/Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infections) and SIBO (small intestinal bacterial overgrowth). We talk about the causes of each: for PANS/PANDAS, it's viral and for SIBO, it's bacterial (streptococcus). I also talk about two scientific journal papers I found that link PANS to viral coinfections in ~28% of cases and PANDAS linked to HHV-6 coninfections as well. We talk about the importance of celery juice and Medical Medium approved supplements in fighting these infections... A very enjoyable episode so full of information your mind will meltdown....! Mark and Michelle Hedges have been married 25 years. For the first 19 years of the marriage, Mark was an undiagnosed autistic. In 2013 and for the next 6 years they went on the GAPS Diet and then the Medical Medium Diet to improve Michelle's health and heal Mark's autism. It worked! Now we offer coaching programs and one on one consultations to get you on your way to healing! Download our book at www.healyourautism.com. Find us on Facebook at the same name. We hope to see you there.

David Fajgenbaum, MD, of the University of Pennsylvania, Philadelphia, is a pioneer in the research of Castleman disease and he’s a patient himself. He joins Blood & Cancer host David Henry, MD, of Pennsylvania Hospital, Philadelphia, to talk about the presentation of Castleman, available treatments, and his own patient journey. Plus, in Clinical Correlation, Ilana Yurkiewicz, MD, of Stanford (Calif.) University, talks about compassion fatigue among friends and family of cancer patients. This Week in Oncology Time Stamps: This week in Oncology (03:51) Interview (07:24) Clinical Correlation (34:15) Show notes Castleman disease is a group of disorders unified by certain histologic features, including: Atrophic (B-cell depleted) germinal centers with wide mantle zones. Increased number of plasma cells in the interfollicular space. Increased number of blood vessels in the interfollicular space. The disease can be subdivided into unicentric Castleman disease (UCD) or multicentric Castleman disease (MCD), based upon the extent of the lymph node involvement. Multicentric Castleman is further subdivided into HHV8-associated and non HHV8-associated (idiopathic) disease. Determination of HHV-8 status is very important for the selection of the appropriate therapeutic strategy. The presentation of Castleman Disease may be similar to the presentation of lymphomas, including fatigue, night sweats, peripheral edema, pancytopenia, and disseminated lymphadenopathy. The diagnosis depends on the unique histologic appearance after bone marrow biopsy is performed. Patients with Castleman disease often require hospitalization given rapid progression of symptoms due to massive cytokine release. MCD is a rare clinical entity, and to date, only one randomized controlled trial has been published to date (involving siltuximab). Therapeutic options: Unicentric Castleman disease Effectively treated with surgical excision of enlarged lymph node. Multicentric Castleman disease Rituximab (anti-CD20 monoclonal antibody) Has been used off-label as first-line treatment in HIV-positive/HHV-8-positive MCD, alone or in combination with conventional chemotherapeutics. Siltuximab (anti-IL-6 monoclonal antibody) Currently the only approved treatment of idiopathic MCD in the United States. Tocilizumab (humanized IL-6 receptor antagonist) Approved for treatment of idiopathic MCD in Japan. Sirolimus (mTOR pathway inhibition) Under investigation at the University of Pennsylvania for treatment of patients who have been refractory to IL-6 blockade. Bortezomib (selective proteasome inhibitor) and Anakinra (IL-1 receptor antagonist) A small number of case reports suggest these may be used in MCD.   Dr. Fajgenbaum can be reached at davidfa@pennmedicine.upenn.edu. More information about Castleman disease can be found at www.cdcn.org.  Dr. Fajgenbaum’s memoir is Chasing My Cure: A Doctor’s Race to Turn Hope into Action Show notes by Sugandha Landy, MD, resident in the department of internal medicine, University of Pennsylvania, Philadelphia.   For more MDedge Podcasts, go to mdedge.com/podcasts Email the show: podcasts@mdedge.com Interact with us on Twitter: @MDedgehemonc Ilana Yurkiewicz on Twitter: @ilanayurkiewicz    

Pod in, Pod out. City of Pod. Menace 2 the Pod. Podz n the Hood... HHV präsentiert: DRESS RELIEF - INTERLUDE No.2! Wir reden in diesem Interlude mit unserem rappenden Freund Bennesois über Hood Filme. Es gibt Name Dropping vom Feinsten, Schwärmerei für die Garderobe von Nino Brown und O-Dog und viel reales Gerede. RIP Ricky. RIP Cousin Harold.

Hvad gør man, når man har problemer med psyken, afløser det ene dårlige forhold med det næste, får en stalker-Henning på nakken, rager kønssygdomme til sig, bor i et dysfunktionelt kollektiv, har søde, men ulydige børn med en eksmand, der har en form for psykose og derfor jagter en rundt i Ranargatas gader midt om natten, har et forhold til en gift forfatter, der bare gerne vil have det lidt sjovt, inden han tager hjem til konen, og var ude for et seksuelt overgreb af en art, da man var antropolog i Amazonjunglen - man splitter sig op i lige dele personer til antal problemer: Hannah, Ann Virmosch, Hanne, Anne, Anita, Hanuta, Hanella, Hinterbella Hüüfgarden Viemoza, h, Ana Viemoza, Ana Doloroza Honningblomst Viemoza, Hanneh Veehmosch, Anna frá Eyrarbakki. Sådan gør hovedpersonen i Hanne Højgaard Viemoses seneste roman HHV, FRSHWN med undertitlen Dødsknaldet i Amazonas, hvert fald. Det er en rodet og rå omgang, som efterlader dig med et AV! Men sådan skal litteratur være nogle gange, for livet er barskt, og det er rodet ,og det er somme tider fyldt med problemer, som man bare må udholde eller forsøge at løse. Til gengæld kan du blive opløftet ved at lytte til Nanna Mogensens interview med Hanne Højgaard Viemose i dagens program. Værter: Klaus Rothstein og Nanna Mogensen.

"HHV, FRSHWN Dødsknaldet i Amazonas" hedder Hanne Højgaard Viemoses nye roman. En rå og usentimental roman om en forfatter, der ripper op i fortidens oplevelser i teenageårene og i ungdommen. Hanne Højgaard Viemose er gæst hos Anne Glad. Anbefalinger i denne episode: Hanne Højgaard Viemose, HHV, FRSHWN Dødsknaldet i Amazonas. Thorbergur Thordarson, Undervejs til min elskede. Morten Pape, Planen. Malene Ravn, I dine øjne. Vært: Anne Glad.

With productions out on Jakarta Records, HHV.DE and Urban Waves Records, and along the lines of blessing the globe with an upcoming album; Producer and DJ Leon Giseke a.k.a. Bluestaeb takes up the decks for a meticulous curation with the aim of building bridges through music, aurally uniting a world of hatred and division. This time from Berlin via Paris to Mauritius, Bluestaeb takes you onboard through the music up in his current soundscape, with an hour of the freshest beats and groovy classics to get you soul'ed out. Visit the link below for tracklist, interview, and download:  http://electrocaine.com/podcast/095/ Stalk us:  www.facebook.com/electrocaineHQ www.twitter.com/electrocaineHQ www.instagram.com/electrocaine

  Charles Ortleb, the former Publisher and Editor-in-Chief of New York Native, debunks the scientific empire that has enriched Anthony Fauci and made him an iconic figure in American science and medicine. Ortleb argues that, like Bernie Madoff', Fauci has built his reputation on fraud and deceit. For at least two decades, Madoff ran a financial Ponzi scheme while Fauci has run a scientific Ponzi scheme for more than three decades. While Bernie Madoff defrauded 4,800 people out of their money, Fauci's HIV Ponzi scheme has undermined the health and civil rights of millions of people all over the world. Ortleb argues that Fauci's AIDS empire should be considered a criminal enterprise and that the AIDS-related HHV-6 epidemic (which includes Chronic Fatigue Syndrome) will only end when Fauci's HIV Ponzi scheme ends. All of Ortleb's books on Chronic Fatigue Syndrome and AIDS can be found here. Read a free book about Anthony Fauci, the Bernie Madoff of AIDS and CFS here. You can show your approval and support for this radio show by buying one or more of Charles Ortleb's books on the dishonest science and politics of Chronic Fatigue Syndrome, HHV-6, HIV, and AIDS.           Charles Ortleb's books on Amazon   All are available in print and Kindle versions. The Chronic Fatigue Syndrome Epidemic Cover-up The definitive history of the intertwined epidemics of AIDS and Chronic Fatigue Syndrome.    The Chronic Fatigue Syndrome Epidemic Cover-up Volume Two     Iatrogenocide Notes for a political philosophy of epidemiology and science inspired by the fraud and deceit in AIDS and Chronic Fatigue Syndrome research.       The Stonewall Massacre A provocative work of fiction that asks what would have happened is the gay movement had been totally destroyed at the Stonewall Riots.       Pig: A Memoir The Animal Farm for a new generation. A laugh-out-loud political satire about the new totalitarianism of public health.     Butterfly Ghosts Charles Ortleb's stunning first collection of poetry.       The Last Lovers on Earth   The Closing Argument Iron Peter   Silence, Exile, and Cunning   Holocaust II His play:The Black Party   His albums on Spotify (as lyricist)   Collaboration   * The Lady Upstairs   *   The Girl from Perkins Cove   *   Hey You   *   Existentialist     Listen to "The Lady Upstairs," the album on Spotify inspired by The Chronic Fatigue Syndrome Epidemic Cover-up. Lyrics by Charles Ortleb. Music and performance by Chris Davidson. This album is also available on Amazon, Apple Music, iTunes, Google, and Deezer. Please help raise awareness about Chronic Fatigue Syndrome by including these songs on your Spotify list and by sharing them with your friends and family.   n>

An excerpt from The Chronic Fatigue Syndrome Epidemic Cover-up available at CFSbook.com   If you want to know the truth about the Chronic Fatigue Syndrome epidemic, you need to discover the reporting of Neenyah Ostrom. And you have to be brave enough to learn about the relationship between the Chronic Fatigue Syndrome epidemic and AIDS. Chronic Fatigue Syndrome is a serious immunological illness that seems to be caused by a very destructive virus. To fully understand the seriousness of the Chronic Fatigue Syndrome epidemic, you need to go back in time. On April 16, 1996, Congressman Jerrold Nadler spoke on the floor of Congress about his request for a General Accounting investigation into how the CDC had handled the Chronic Fatigue Syndrome epidemic. Nadler did that at the urging of Charles Ortleb, the publisher of the New York Native, and his reporter Neenyah Ostrom. Ortleb and Ostrom had made the case to Nadler that Chronic Fatigue Syndrome and the virus it had been linked to, HHV-6, were serious public health issues. In an interview in New York Native with Neenyah Ostrom, Congressman Nadler said, "Congress can mandate research into CFS as a viral disease. Maybe it will turn out that HHV-6A is the cause of CFS; maybe it will turn out that other viruses are involved. But Congress can mandate research into CFS as a contagious, viral disease. I will certainly try to get Congress to do that as soon as possible." Unfortunately, back in 1996, Nadler's warning to Congress and the medical establishment fell on deaf ears. But now that the Democrats have regained power in the House of Representatives, the newly prominent Congressman Nadler may finally be able to bring the CFS epidemic and HHV-6 to the public's attention. This book by Charles Ortleb, which details Neenyah Ostrom's diligent reporting on Chronic Fatigue Syndrome, is necessary reading for anyone who wants to know the whole history of an epidemic which has been hidden in plain sight. For a decade, starting in 1988, Ostrom reported on Chronic Fatigue Syndrome and the damage that the virus HHV-6 does to patients. What her reporting uncovered about the nature of the Chronic Fatigue Syndrome epidemic will shock you. In The Chronic Fatigue Syndrome Epidemic Cover-up, Charles Ortleb recounts his newspaper's fascinating struggle to get the medical and political establishment to pay attention to Ostrom's pioneering investigative reporting on CFS. By the time you finish Ortleb's stunning memoir, you will understand why the CDC has been unwilling to tell the truth about Chronic Fatigue Syndrome. The CDC does not want the public to know that CFS is a transmissible illness linked to a virus that affects every system in the body. They have covered up CFS for so many decades that the neglected virus is totally out of control. Now it is causing a long list of other illnesses and many cancers. The CDC has put us all in danger. Ostrom's decade of reporting on HHV-6 was recently vindicated by this statement from scientists at the University of Wurzburg:"While HHV-6 was long believed to have no negative impact on human health, scientists today increasingly suspect the virus of causing various diseases such as multiple sclerosis or chronic fatigue syndrome. Recent studies even suggest that HHV-6 might play a role in the pathogenesis of several diseases of the central nervous system such as schizophrenia, bipolar disorder, depression or Alzheimer's." The big question about Neenyah Ostrom and New York Native is this: How many lives would have been saved if the scientific establishment and the mainstream media had paid more attention to Neenyah Ostrom's reporting on HHV-6 and Chronic Fatigue Syndrome in New York Native? Anyone who wants to help Congressman Nadler and the other members of Congress who are trying to end the suffering of millions of people with Chronic Fatigue Syndrome, needs to read The Chronic Fatigue Syndrome Epidemic Cover-up.   Listen to "The Lady Upstairs," the album on Spotify inspired by The Chronic Fatigue Syndrome Epidemic Cover-up. Lyrics by Charles Ortleb. Music and performance by Chris Davidson. This album is also available on Amazon, Apple Music, iTunes, Google, and Deezer. Please help raise awareness about Chronic Fatigue Syndrome by including these songs on your Spotify list and by sharing them with your friends and family.   n>

Main Topic: This week we got to know the duo behind the finest adapters in the game, Damir Brand. Damir is a two person operation between Dee and Hector. They're the owners and operators of the company and have been featured by Turntable Lab, Pitchfork, HHV.DE and DJ City. They talk about their days growing up in El Paso, what lead them to Phoenix and the creation of the company as well as shed light on how to keep moving forward in the face of adversity and so much other wisdom. We've always been a fan of their products but being able to hear about all of the passion and time that goes into each adapter definitely sparks a new sense of admiration and respect into what they're providing. Shout out to @Palabras_Bookstore for providing the space for us to record in. Instagram: @damirbrand / @damirforty5 Website: www. DamirBrand.com Instagram: @JustKeepSpinningPodcast Inquiries: JustKeepSpinningPodcast@gmail.com

Live Right Now - Episode 021 – Celebrating Celery   In the Mediterranean, crunchy celery has been cultivated and used as food and medicine for millennia.  Although, in America celery, meh, it’s been diminished; just another dreaded veggie we’re ‘forced’ to eat. King Tut’s tomb contained a shroud adorned with wild celery garlands. Hippocrates believed celery to sooth nerves.  In ancient Rome, celery was considered an aphrodisiac as celery contains androsterone, a pheromone released by men’s sweat glands that attracts females. Oo-la-la! So much more, celery seeds contain about 25 anti-inflammatories that protect against painful flare-ups and other health issues. Cleveland Clinic (CC) says celery may be able to control high blood pressure. While the initial craze was eating celery seeds for this purpose, CC says whole celery stalks are the way to go. The autoimmune confusion is huge blunder in modern medicine. Over 250 million Americans live and suffer no relief from mystery symptoms and conditions caused from eating fake manmade food. Celery juice teems with powerful anti-inflammatories highly beneficial for people who suffer “autoimmune.” Hashimoto’s thyroiditis, RA, fibromyalgia, chronic fatigue syndrome (ME/CFS), Lyme disease, migraines, vertigo, celiac disease, irritable bowel syndrome (IBS), diabetes, psoriasis, eczema, acne, lupus, Guillain-Barré syndrome, sarcoidosis, Raynaud’s syndrome, Ménière’s disease, GERD, gout, bursitis, bloating, intestinal cramping, distention, acid reflux, vertigo, constipation, restless leg syndrome, tingles, numbness. Celery contains a multitude of mineral salts acting symbiotically as an antiseptic. When these powerful mineral salts make contact with viruses such as Epstein-Barr, HHV-6, and shingles; bacteria such as Streptococcus; and other pathogens the salts begin to break down the pathogens’ cell membranes, eventually killing and destroying the villains. Celery’s breaks down and flushes out viruses, including EBV and shingles, Every morning, drink roughly 16 ounces of plain, thoroughly washed, fresh celery juice on an empty stomach. (about one whole stalk) Wait at least 15 minutes after drinking your celery juice before breakfast. Use washed, organic or conventional celery whenever possible. Taking warfarin or other blood thinners?  Celery contains vitamin K. If you still refuse the truth that eating from God’s pharmacy prevents and cures just about every mental and physical disease, then you’re sleepwalking through “Denial-land” or simply don’t give a damn about their sacred gift of life. Source who created us in His image, didn’t designed us to be imperfect.  We enter earth a perfect temple that innately knows what to eat, but then were taught to hate veggies and eat dead food from man’s polluted factories.  Really?   For more from Chef Wendell including the “Eat Right Now” books and info on how to book Chef Wendell to speak to your group go to http://www.chefwendell.com. To connect with the Live Right Now Podcast “like” our Facebook page or email us at LiveRightNowRadio@gmail.com.   The Live Right Now theme music is “future soundtrack II” by Adam Henry Garcia from the Free Music Archive licensed under CC BY-NC-SA 4.0  

The Closing Argument    A 2-hour audio book that brings the racial and sexual politics of the Chronic Fatigue Syndrome epidemic out of the closet. Listen to The Closing Argument now on Amazon and at Audible  On Amazon On Audible in the USA On Audible in the U.K. On Audible in France On Audible in Germany This bold, uncompromising book is the Uncle Tom's Cabin of the AIDS and chronic fatigue syndrome epidemics. It's one of those books that will inspire you to think outside of the box. Destined to be a controversial independent film, The Closing Argument is a provocative courtroom novella about an African-American man who is tried in Connecticut for the crime of infecting a woman with HIV, the virus that the American government has declared the official cause of AIDS. In a move that shocks the nation, his attorney puts the government and the AIDS establishment on trial and tries to convince the jury that everything the public has been told about the nature of the AIDS and CFS epidemics is both racist and homophobic. The author makes you the jury and you have to decide from the attorney's closing argument if you can believe anything you've been told about AIDS, chronic fatigue syndrome, HIV and HHV-6. This is the first work of fiction in history to focus on the cover-up of the devastating virus HHV-6 which has now been linked to many diseases in addition to AIDS and chronic fatigue syndrome. Nicholas Regush, former producer at ABC News called the book "Eye-popping reading if you dare to expand your scope of thinking about AIDS and justice." From 1980 until 1997, Charles Ortleb was the publisher and editor-in-chief of New York Native which Wikipedia describes as "the only gay paper in New York during the early part of the AIDS epidemic" which "pioneered reporting on the AIDS epidemic when others ignored it." On May 18, 1981, New York Native published the world's very first report on the disease that would become known as AIDS. In his book, And the Band Played On, Randy Shilts described the New York Native coverage of the epidemic as being "singularly thorough" and "voluminous." In Rolling Stone, David Black said that New York Native deserved a Pulitzer prize for its AIDS coverage. In an interview in New York Press, Nicholas Regush, a producer for ABC News and a reporter for Montreal Gazette, said that New York Native did "an astounding job" in its coverage of AIDS and credited it with "educating him early on." In a profile titled "The Outsider" in Rolling Stone in 1988, Katie Leishman wrote that "It is undeniable that many major AIDS stories were Ortleb's months and sometimes years before mainstream journalists took them up. Behind the scenes he exercises an enormous unacknowledged influence on the coverage of the medical story of the century." In addition to pioneering the coverage of AIDS, New York Native was the only publication in the world to have a reporter, Neenyah Ostrom, who provided weekly coverage of the emergence of the epidemic of chronic fatigue syndrome and its scientific and political relationship to AIDS. Hillary Johnson, in her groundbreaking history of chronic fatigue syndrome, Osler's Web, wrote that "Ortleb, in fact, increasingly suspected the AIDS outbreak was merely a modest subset of the more pervasive, immune-damaging epidemic disease claiming heterosexuals--chronic fatigue syndrome." The breaking news about chronic fatigue syndrome and HHV-6 these days seems to suggest that much of New York Native's controversial take on the relationship between AIDS, chronic fatigue syndrome and HHV-6 is being vindicated.       Listen to "The Lady Upstairs," the album on Spotify inspired by The Chronic Fatigue Syndrome Epidemic Cover-up. Lyrics by Charles Ortleb. Music and performance by Chris Davidson. This album is also available on Amazon, Apple Music, iTunes, Google, and Deezer. Please help raise awareness about Chronic Fatigue Syndrome by including these songs on your Spotify list and by sharing them with your friends and family.   n>

The Stonewall Massacre The beginning was the end.   Ken Kamlet narrates one of the most important works of fiction that Charles Ortleb has ever written. The lengthy short story is a work of alternative history that imagines what would have happened if the gay movement in had been destroyed in its infancy. What if the Stonewall riots had resulted in a bloody suppression of gay people all over America? What would society be like now? Would there have been an AIDS epidemic? "The Stonewall Massacre" is told from the perspective of a waiter who witnesses the destruction of the gay community in 1969 in Greenwich Village. In this thought experiment, the Stonewall Riots fail and lead to a massive backlash against the gay community. He watches in horror as an antigay backlash takes place all over America. What happens to the gay community in this story resembles what is happening to gays across the globe these days. But that is just the beginning. This witty and visionary story jumps ahead to the outbreak of the Chronic Fatigue Syndrome epidemic. Because there is no visible gay community and no visible gay AIDS epidemic, Chronic Fatigue Syndrome is recognized as the real AIDS epidemic. Without a gay community to scapegoat, the women who are first victims of Chronic Fatigue Syndrome find themselves being treated as AIDS pariahs. Written by one of the most uncompromising American journalists and the author of "The Chronic Fatigue Syndrome Epidemic Cover-up," this story raises uncomfortable questions that have the potential to change the course of history. This story is also a kind of coming out of the virus HHV-6, a virus which Ortleb has called "The Fifty Shades of AIDS virus," because it has been linked with many diseases that seem to be connected to the AIDS epidemic. For decades, Charles Ortleb has been criticized and mocked for focusing his journalism on HHV-6. But that is now changing. Ortleb's reporting on HHV-6's role in multiple diseases was recently vindicated by this statement from the University of Wurzburg: "While HHV-6 was long believed to have no negative impact on human health, scientists today increasingly suspect the virus of causing various diseases such as multiple sclerosis or chronic fatigue syndrome. Recent studies even suggest that HHV-6 might play a role in the pathogenesis of several diseases of the central nervous system such as schizophrenia, bipolar disorder, depression or Alzheimer's." By the time you finish this provocative story, you'll want to read all of Charles Ortleb's historically important work on the Chronic Fatigue Syndrome and HHV-6 epidemics. Available at Audible in the U.S.A. here. Available at Audible in the U.K. here. Available at Audible in France here. Available at Audible in Germany here. Print, Kindle, and audio versions of this book are available at StonewallMassacre.com      Listen to "The Lady Upstairs," the album on Spotify inspired by The Chronic Fatigue Syndrome Epidemic Cover-up. Lyrics by Charles Ortleb. Music and performance by Chris Davidson. This album is also available on Amazon, Apple Music, iTunes, Google, and Deezer. Please help raise awareness about Chronic Fatigue Syndrome by including these songs on your Spotify list and by sharing them with your friends and family.   n>

Charles Ortleb, the publisher of New York Native and author of The Chronic Fatigue Syndrome Epidemic Cover-up, interviews Hillary Johnson, the first journalist to cover the Chronic Fatigue Syndrome epidemic in Rolling Stone. She is also the author of Osler's Web: Inside the Labyrinth of the Chronic Fatigue Syndrome Epidemic. Visit her website Oslersweb.com for all her latest reporting. All of Charles Ortleb's books about HHV-6, Chronic Fatigue Syndrome, AIDS and the politics of science can be found at CharlesOrtleb.com. About Charles Ortleb's Amazon Bestseller, The Chronic Fatigue Syndrome Epidemic Cover-up If you want to know the truth about the Chronic Fatigue Syndrome epidemic, you need to discover the reporting of Neenyah Ostrom. For a decade, starting in 1988, Ostrom reported on Chronic Fatigue Syndrome for a newspaper called New York Native. What her reporting uncovered about the true nature of the Chronic Fatigue Syndrome epidemic will shock you. In The Chronic Fatigue Syndrome Epidemic Cover-up, Charles Ortleb recounts his newspaper's struggle to get the medical and political establishment to pay attention to Ostrom's pioneering investigative reporting on Chronic Fatigue Syndrome. By the time you finish Ortleb's stunning memoir, you will understand why the Centers for Disease Control has been unwilling to tell the public the truth about Chronic Fatigue Syndrome. The CDC does not want the public to know that Chronic Fatigue Syndrome is a transmissible illness linked to a virus called HHV-6 that affects every system in the body. They have covered up the illness for so many decades that the neglected virus is totally out of control. Now it is causing a long list of other illnesses and many cancers. Nobody in the world covered the emergence of HHV-6 and its link to Chronic Fatigue Syndrome more than Neenyah Ostrom. Ostrom's decade of reporting on HHV-6 was recently vindicated by this statement from scientists at the University of Wurzburg: "While HHV-6 was long believed to have no negative impact on human health, scientists today increasingly suspect the virus of causing various diseases such as multiple sclerosis or chronic fatigue syndrome. Recent studies even suggest that HHV-6 might play a role in the pathogenesis of several diseases of the central nervous system such as schizophrenia, bipolar disorder, depression or Alzheimer's." The big question about Neenyah Ostrom and New York Native is this: How many lives would have been saved if the scientific establishment and the mainstream media had paid more attention to Neenyah Ostrom's reporting on HHV-6 and Chronic Fatigue Syndrome in New York Native? One day, if there is any justice in the world, the CDC and the medical establishment will apologize for not paying attention to Neenyah Ostrom's groundbreaking work on Chronic Fatigue Syndrome that Charles Ortleb published in New York Native. That would be a fitting end to one of journalism's greatest David and Goliath stories. Read a free excerpt at www.CFSbook.com     

Charles Ortleb, the author of The African Swine Fever Novel and The Chronic Fatigue Syndrome Epidemic Cover-up, discusses research and reports that link African Swine Fever to illnesses in humans and pets. Did Robert Gallo steal the African Swine Fever discovery by John Beldekas as give ASFV the new name of "HHV-6"? Has African Swine Fever been infecting people all over the world for decades and will it be a public health problem in China and Western Europe? Is it already an unrecognized problem in the United States? The African Swine Fever Novel is available at Amazon at www.pignovel.com  

Today's topic is hot with 3 major papers in the last few months, that is the viral hypothesis of Alzheimer's disease. Alzheimer's disease (AD) was estimated to affect 35.5 million people worldwide in 2010 and is expected to affect 115.4 million people by 2050. Four members of the Human Herpes Virus family have been associated with development of Alzheimer's disease; HSV-1, VZV, HHV-6A, and HHV-7. My guest today says its time to put it to the test. Joining today is infectious disease physician, Steven LaRosa, MD.

Blakka Blakka! Für Folge 10 bin ich nach Berlin gereist um mich bei glühender Hitze, eisgekühltem Radler und offenem Fenster (Sorry!) mit Ecke Prenz alias Breaque und V.Raeter zu treffen. Wir haben über Würstchen, DJing, Mixtapes, ihr anstehendes Produzenten-Debutalbum ""Nachts im Thälmann Park"" und alle möglichen anderen Themen gesprochen. Respekt an Musik! Viel Spaß beim Anhören!   Ecke Prenz, Breaque und V.Raeter eckeprenz.de Ecke Prenz Show auf Mixcloud Ecke Prenz bei Twitter Ecke Prenz bei Facebook Ecke Prenz bei Instagram Breaque bei Twitter Breaque bei Facebook Breaque bei Instragram V.Raeter bei Twitter V. Raeter bei Facebook V. Raeter bei Instragram   Album "Ecke Prenz - Nachts im Thälmannpark" Album auf HHV.de Album auf Amazon Music "Changes (1055) // Grüße" Musikvideo auf YouTube "Lada Niva" Single auf YouTube "Lada Niva" Single auf Spotify "Grüße" Single auf Spotify "Change 1055" Single auf Spotify   All I See Is Blinkin' Lights All I See Is Blinkin' Lights - Anhören & Social Media   Shownotes Funk Viertel #1 Tape auf YouTube Hiob aka V-Mann - Fragmente auf Spitfy Sichtbeton auf Spotify Spoken View Fatoni & V. Raeter bei Pfeiffers Ballhaus mit "Kann nicht reden ich esse" Fatoni & V. Raeter bei Pfeiffers Ballhaus mit "Mike" Tagesspiegel - Polizei schloss Berliner Hip-Hop-Sender "Twen FM" Offizieller Breaque Fanclub bei Twitter Breaque - Nebelstadt 1-3 bei Soundcloud Tony Touch Mixtape 50 Audio88 & Yassin - Kein Richtiges Lied Musikvideo bei YouTube Elsa Klever Illustration - Homepage Instagram Album zur Ecke Prenz Mixsession bei Dexter MC Bomber's Instagram Comment zum Cover Hiob - Drama Konkret Musikvideo auf YouTube (Video von Ecke Prenz) "Changes (1055) // Grüße" Musikvideo auf YouTube

Jim Goetz Dr. Mike Brandon Chantea Goetz   The big announcement is that our BiohackHumans website now has an Insiders Only Section. Be the first to see world class workout programs, high quality recipes, videos, how Dr. Mike Brandon lost 30 lbs in 5 days step by step and m uch much more!!!!    New Theories Behind The Real Cause of Lymes Disease and Possible Natural Treatments Jim Goetz   Since the 1970's in the town of Lymes, Connecticut, individuals have been coming down with a mysterious illness diagnosed as many things. The symptoms are pretty much the same. They include: fatigue, muscle pain, weakness, twitching, spasms, restless leg syndrome, mental fog, joint pain, swelling, and tingling in the extremities. (These symptoms sounds seriously like every night after my three times per day workouts). Because of the grouping of symptoms, health officials believed they needed to find the cause of this new "disease". A few years later, an individual who had these symptoms stated they reported having a tick on them a few weeks prior to the symptoms occurring. Researchers found this specific type of tick to carry the bacteria Borrelia burgdorferi and "hallejuia" an answer was found (though it was based on mere observation). Lymes has traditionally been treated by using a very large dose full spectrum anti-biotic. Patients often get better at first giving doctors the impression that the drugs are working. This is called a Herxheimer reaction. That is symptoms reverse. Now with this dose of antibiotics, your body is also losing beneficial bacteria that your body needs to function and yes, even think. Unfortunately antibiotics at times casue viruses to strengthen. In this case, this is true.  Recently there has been some speculation that Lymes disease is also caused by other bacteria such as Bartonella or parasites such as Babesia. None of these however or Borrelia actually seem to be responsible for the actual symptoms of Lymes disease. Someone may test positive for one of these bacteria or parasites and have Lymes disease but this again may only be another observational study and the two may have nothing to do with another. This is like someone observing an individual with a cold having eaten a pizza just the day prior and no other foods. Therefore colds must be caused by pizza. This simply is not the truth.  The symptoms of Lymes disease are the same as those who have Epstein-Barr, HHV-6 and it's varous strains. Some also test positive for cytomegalo virus. These are all viruses!!! Exactly!!!!! Lymes disease may actually be a virus that most of us have that is actually triggered by events in life.  All of these items in some way or another lower ones immune response. As a result, a dormant virus can take over. These possible causes include (but not limited to: -mold -mercury based dental mamlgam fillings -mercury in general -emotional events such as the loss of a loved one or traumatic event -bites or stings -virus enabling prescripton medications (see benzodiazepines) -overprescribed medications -recreational drug abuse -overly stressful chronic situations such as finances -lack of sleep -poor nutrition -chemicals in ones environment such as carpets or carpet cleaning products, paint, etc. -runoff -swimming (chlorine is highly toxic in pools as are red algae blooms in the ocean)   Some natural treatments include but are not limited to: -thyme (kills viruses on contact). I often use this in a diffuser and breathe it in the room, especially in fall and winter. I have no proof it works but know I do not get sick often. -lemon balm (kills co-factors of viruses). It's also naturally soothing and used in many good bed time/ relaxation formuals. -zinc (lowers inflammation and may raise immune levels) If you put a zinc losenger in your mouth though and it tastes highly metallic, your zinc levels may already be normal and therefore risk toxicity. -licorice root (impairs viral movement and ability to reproduce) -L-lysine (same as licorice root). However, L-lysine is used during herpes outbreaks as it appears to be directly inverse to L-Arginine, a vasodialator. L- Arginine and foods containing this amino acid are to be avoided during times of outbreaks. -Lomatium root (removes pathogens from the body). -reishi mushrooms (increases lymphocytes, and neutrophils, which are white blood cells responsible for immune function). -silver hydrosol (kills viruses on contact) -astaxanthin (restores neurological function) This is found in krill supplements and Green Vibrance. Both area a staple in the diet of the madscientist himself. -nascent iodine (strengthens the encocrine system)   Swing Away Depression and Anxiety Dr. Mike Brandon Jumping on a trampoline, swinging in the park, running in circles, and rolling down hills may sound like a day's summer schedule for a child, but what about as a way to help combat depression, anxiety, and memory deficits in us all. Our body's vestibular system is what helps us with our balance and equilibrium and allows us to do things like walking and standing upright, standing on one leg, walk across a tight rope etc. The majority of this system is small structures buried within our ears which works with our eyes and specific regions of our brain. It gets strengthened via body and head movements like rolling, jumping, spinning, and so forth. We rarely think about it unless there's an issue like becoming dizzy or losing balance, but clearly this system is important for us. Could you imagine trying to go through a day without being able to walk 10 feet without falling to the side? Science has found however that having a healthy balancing system may also help with stress, anxiety and depression. It appears that having vestibular dysfunction, like dizziness or vertigo, can cause increased anxiety and stress, and even the reverse with having excess stress or anxiety disorders could cause dizziness or vertigo. So clearly they are related, but why does that matter?​ There was a study that took college students and gave them “swing time” every day, meaning they literally went to a park, sat on a swing and swung back and forth for a while. This caused all participants to have a positive change on their emotional state with depression, stress, and anxiety. This led me to think about children and the importance of recess. Its been over the news the past few years when it was shown that increased play time increased academic performance. This could be a big part as to why. Children's brains are still developing, so having kids “just be kids” and run, roll, and jump, is quite important so they have a better chance at staying happy and coping with the stress that inevitably arises in life. Currently, kids don't play as much as they used to due to tv, video games, and similar activities, so their vestibular system which is linked to strong emotional control and satisfaction may not get fully developed. Add to that then how most of us as adults live rather sedentary lives and sit most of the day, so we aren't strengthening our equilibrium and balance systems either. The good news is, that it appears that even as adults we can help ourselves by “just being a kid”.  So maybe I wouldn't advice grandpa to go hop on a merry-go-round or start doing flips on the trampoline, but gently rocking in a chair or standing on a wobble board for a while may help his occasional panic attacks or make him smile a bit more. It shouldn't be surprising then that most people enjoy things such as swinging and spinning. Everybody wants to stay young, and though we have yet to biohack a secret for that, there's clearly benefits by following a child's example in this case. So go make yourself a little dizzy, a little happy, and as always, BioHack on!   References: Dalton, S. (2016, May 11). Youth Fitness: Exercise Helps Children Excel in School. Retrieved June 16, 2017, from http://www.healthline.com/health/youth-fitness-exercise-helps-children-excel-school#5 Eisenbarth, C. A. (2013). Influence of Optimism on Appraised Stress, Depression, and Anxiety Among College Students. Journal of Psychology Research, 3(6), 295-297. doi:10.17265/2159-5542/2013.06.003  Gurvich C., Maller J. J., Lithgow B., Haghgooie S., Kulkarni J. (2013, in press). Vestibular insights into cognition and psychiatry. Brain Res. [Epub ahead of print]. 10.1016/j.brainres.2013.08.058  Halberstadt A. L., Balaban C. D. (2006). Serotonergic and nonserotonergic neurons in the dorsal raphe nucleus send collateralized projections to both the vestibular nuclei and the central amygdaloid nucleus. Neuroscience 140, 1067–1077 10.1016/j.neuroscience.2006.02.053  Mukkadan, J., Rajagopalan, A., Jinu, K., Sailesh, K., Mishra, S., & Reddy, U. (2017). Understanding the links between vestibular and limbic systems regulating emotions. Journal of Natural Science, Biology and Medicine, 8(1), 11. doi:10.4103/0976-9668.198350  Smith, P. F., & Darlington, C. L. (2013). Personality changes in patients with vestibular dysfunction. Frontiers in Human Neuroscience, 7. doi:10.3389/fnhum.2013.00678    biohackhumans.com   Find us: Instagram (@biohackhumans)  Facebook (@biohackhumans) Twitter (@biohackhumans) Tumblr (@biohackhumans)   Contact Us: support@biohackhumans.com

A new study finds that two nearly ubiquitous herpes viruses, HHV-6a and HHV-7, are abundant in the brains of people with Alzheimer’s disease. Also today, midlife retinopathy predicts ischemic stroke, fingernails may hold a clue for relapsing scabies, and canakinumab cuts gout attacks by nearly half.

Hashimoto’s disease can have many triggers including iodine, low birth weight, pregnancy, smoking, mercury, drugs, stress, leaky gut, environmental toxins, and of course infections.  This article will focus on the connection between infections and Hashimoto’s disease. The infection connection and Hashimoto’s disease is something I have been investigating since 2005 when I first learned about the connection between Yersinia enterocolitica and Hashimoto’s disease.  Since then, I’ve been researching the infection connection to Hashimoto’s disease and science continues to shed more light on this area. The vast majority of my patients with Hashimoto’s disease do have some kind of active infection that has been shown to be connected to Hashimoto’s disease.  Let’s go ahead and jump right into what the latest scientific literature has to say about this fascinating area of research. Why do infections trigger Hashimoto’s disease? Molecular mimicry is one explanation for bacterial trigger of the disease.  This basically means that the infection looks similar to your own thyroid tissue so your immune system launches an immune attack on the microbe and your thyroid.  Yersinia enterocolitica is a classic example of this connection. Other explanations are complex immunologic mechanisms that I won’t go into detail here because of the technical nature of the material.  To put one mechanism simply, viruses can reside inside the thyroid gland which triggers immune activation against the virus and the thyroid.  Epstein-Barr Virus and Human Herpes Virus 6 are examples of this mechanism. For those of you with a scientific background who would like to read more about the technical immunologic mechanisms, you can search for the phrases used in this quote, “Possible mechanisms by which infections may trigger thyroiditis include release of sequestered antigens by cell destruction or apoptosis, exposure of cryptic epitopes, molecular mimicry, or via a bystander mechanism resulting in activation of resident T- cells.” This quote is taken from this paper freely available for you to research. Lyme disease and Hashimoto’s disease Borrelia burgdorferi is the spirochete that causes Lyme disease and there is some evidence that this bacteria is connected to Hashimoto’s disease.  The data is limited at this point but with Lyme disease, there can be many other indirect factors and co-infections that could potentially be involved in triggering Hashimoto’s disease. Patients with Lyme disease also tend to have some of the predisposing factors to autoimmune diseases such as a compromised digestive tract, inflammation, and tremendous oxidative stress. Yersinia enterocolitica and Hashimoto’s disease I have written about and recorded a podcast previously about the connection between Yersinia enterocolitica and Hashimoto’s disease.  There is good evidence of this connection so it is important to get tested if you have Hashimoto’s disease.  This can be done with a stool test and/or blood test. Helicobacter pylori and Hashimoto’s disease I cover this connection in detail in this article and podcast. Viruses and Hashimoto’s disease The following viruses have been shown to potentially trigger Hashimoto’s disease: Coxsackievirus B Rubella Enteroviruses Epstein-Barr Virus Human Herpes Simplex Virus 6 (HHV-6) Mumps Parvovirus B-19 Hepatitis B Hepatitis C The Hepatitis C virus actually has the strongest infection connection to Hashimoto’s disease.  In fact, studies have shown that this virus can actually reside outside of the liver inside the thyroid gland thus triggering autoimmunity. Can we be certain that the virus triggered the autoimmunity? This can be difficult to make a definitive conclusion about the direct connection due to the interaction between the virus and the patient’s immune system.  Some viruses like the Epstein-Barr Virus and Herpes 6 can be activated inside the thyroid gland but there is no im...

Paul Anderson, ND, shares insights from his 25-year career in treating complex diseases with natural remedies, with a focus on cancer. We discuss exciting new research about how natural therapies affect cancer development and progression and how the once chemo-and-radiation-centered field of oncology is embracing lower side effect therapies: keto, fasting and immune modulators. New Book: Outside the Box Cancer Therapies: https://amzn.to/2rC2PMe Connect with Dr. Paul: http://www.drabooks.com ----New Low-Carb eCourse------------ Raw Veggie Bread Creations: https://courses.highintensityhealth.com/p/raw-veggie-bread-creations-spring   ----Key Timestamps------------     03:24 Dr. Anderson’s travel health strategies. 05:03 Breast cancer recurrence dropped with fasting 05:21 The biochemistry changes after 3 to 4 months of intermittent fasting of 13 to 14 hours, even in non-cancer patients. 07:29 Intermittent fasting. 09:02 Hospitals are embracing intermittent fasting around chemo 11:15 People who respond best to natural treatment are those who tend to the basics and take care of their overall health. 13:42 Chemotherapy has evolved in the past 5 to 10 years to be more targeted. 15:08 Some targeted chemotherapies work well, others have deadly side effects or cancer coming back stronger. 16:10 The trophoblastic theory is the cancer stem cell theory. Once the main cancer tumor has been destroyed, the cancer stem cells step back and wait. 18:27 The more we quiet inflammation and regulate blood sugar, the less likely it is that cancer stem cells will activate. 19:19 Secondary prevention includes and goes beyond diet and lifestyle. Other issues must be addressed: immune issues, chronic infections in the lymphatic system, toxin burdens, and hormonal aberrations. 24:36 Aberrant thoughts affect the immune system. 28:03 Cancer stem cells stay with the blueprint and the rest are the soldier cancer cells that we see. The stem cells, are generally not affected by the treatment that destroys the soldiers. 29:53 Cancer stem cells have the ability to recruit and program normal cells. The harder we hit the cancer soldier stem cells with chemo radiation, the more the stem cells back away from the area and wait. 31:06 The strategy is to keep cancer stem cells happy and quiet. 33:44 A very low carb or keto diet was a common link in cancer patients that did the best with their therapies, longer remissions or no recurrence. 37:13 Research has found that integrative cancer therapies extended lifespan, compared to only standard therapy. 41:29 Work with at least two practitioners to get many options and varied care. 49:07 By the time we can see a cancer tumor with imaging, it has been growing slowly for 5 to 10 years or longer. 51:00 Prescreening tests are getting better. Next generation testing, which still has some gaps, looks for things like circulating cancer cells. 52:06 Some traditional testing of non-specific inflammatory markers show metabolic shifts to an inflammatory milieu or a milieu that shows Warburg Effect. 58:38 Thermography, when done correctly, can detect and track cancer. 01:03:28 Dr. Anderson tests all cancer survivors for chronic infection, including the family of HHV, mycoplasma, c pneumoniae and more. 01:05:21 People who eat mushrooms regularly have lower rates of certain cancers. Some cancers that do not respond to anything else, will respond to mushrooms. 01:10:45 High protein intake and low quality protein sources can bring you out of cancer fighting mode and out of ketosis. Poor quality protein, and food in general, can bring toxins into your body. 01:14:18 The ideal morning routine for preventing cancer starts with a quiet mind and centering. Exercise in the morning for the brain and body. Hydrate. 01:18:27 Dr. Anderson would choose curcumin as his desert island supplement. Curcumin levels out cytokines and triggering molecules. 01:22:33 Dr. Anderson’s elevator pitch: keep people from developing cancer to is to get them to do the things that bring their metabolism back to its intended balance.

What is your favorite record of all time? In honor of Record Store Day, we asked the proprietors of Berlin record stores Riseikel, HHV, Musik Department, Oldschool, Soul Trade and Dodo Beach.

Charles Ortleb discusses the 1998 research by Dr. Thomas Glass on the possible transmission of Chronic Fatigue Syndrome between people and their pets. He also reads from an article by Neenyah Ostrom published eight years eariler in his newspaper, New York Native. Ostrom reported on a woman with Chronic Fatigue Syndrome whose sick dog tested positive for HHV-6, the virus that in increasingly being linked to Chronic Fatigue Syndrome. This audio is part of a documentary called Beyond Unrest being made by Ortleb. Beyond Unrest will explore the decade of reporting New York Native did on the link between HHV-6, Chronic Fatigue Syndrome, and AIDS. The documentary will put to rest any notion that there is anything mysterious about the Chronic Fatigue Syndrome epidemic. Beyond Unrest will be based on Ortleb's book, The Chronic Fatigue Syndrome Epidemic Cover-up, which is a history of the intertwined nature of the AIDS and Chronic Fatigue Syndrome epidemics. Click to learn more about The Chronic Fatigue Syndrome Epidemic Cover-up.     Listen to Previous Podcasts      

Charles Ortleb, the publisher and editor-in-chief of New York Native, discusses a recent column on Chronic Fatigue Syndrome by Jane E. Brody in The New York Times. He also discusses the reporting he published by Neenyah Ostrom in New York Native on Chronic Fatigue Syndrome three decades earlier. Not only did The New York Times ignore Ortleb's dedication to covering Chronic Fatigue Syndrome epidemic, but the paper also mocked Ortleb when his paper went out of business in 1997 after a coordinated boycott by the AIDS activist group Act Up. Ortleb's account of his newspaper's attempt to bring the Chronic Fatigue Syndrome epidemic to the public's attention can be found in his book The Chronic Fatigue Syndrome Epidemic Cover-up which is available at Amazon   Previous Podcasts    The AIDS and Chronic Fatigue Syndrome Connection   The Disturbing Autism and Chronic Fatigue Syndrome Connection The mathematician who insists that the HIV story of AIDS does not add up.   The "Dediscovery" of HIV: The Australian scientists who almost destroyed the AIDS paradigm and may have inadvertently found the key to the Chronic Fatigue Syndrome epidemic.       The Interview with Dr. Jose Montoya, one of the world's leading Chronic Fatigue Syndrome researchers.     A discussion of Jonathan Lyon, a man with Chronic Fatigue Syndrome whose father had AIDS. Is there a connection? Will he be a better spokesperson for CFS than Laura Hillenbrand and Jennifer Brea?     How the mistakes of CDC researcher Mary Guinan helped create the Chronic Fatigue Syndrome disaster.     Is Anthony Fauci the Bernie Madoff of AIDS and Chronic Fatigue Syndrome?     Why are Chronic Fatigue Syndrome patients infected with the AIDS-associated Kaposi’s Sarcoma Virus? Did it come from pigs?   Chronic Fatigue Syndrome and the Centers for Disease Control's HIV Ponzi scheme.     Are AIDS and Chronic Fatigue Syndrome the New Tuskegee Syphilis Experiment?     An interview with Hillary Johnson, one of the world's most important Chronic Fatigue Syndrome journalists.       *       Please support this radio show by buying one or more of Charles Ortleb's books on the dishonest science and politics of Chronic Fatigue Syndrome, HHV-6, HIV, and AIDS.   Charles Ortleb's books on Amazon   All are available in print and Kindle versions. Truth to Power The definitive history of the intertwined epidemics of AIDS and Chronic Fatigue Syndrome.     Iatrogenocide Notes for a political philosophy of epidemiology and science inspired by the fraud and deceit in AIDS and Chronic Fatigue Syndrome research.       The Stonewall Massacre A provocative work of fiction that asks what would have happened is the gay movement had been totally destroyed at the Stonewall Riots.   Pig: A Memoir The Animal Farm for a new generation. A laugh-out-loud political satire about the new totalitarianism of public health.     Butterfly Ghosts Charles Ortleb's stunning first collection of poetry.     The Last Lovers on Earth The Closing Argument Iron Peter Silence, Exile, and Cunning Holocaust II His play:The Black Party   His albums on Spotify (as lyricist)   Collaboration   * The Lady Upstairs   *   The Girl from Perkins Cove   *   Hey You   *   Existentialist  

You can show your approval and support for this radio show by buying one or more of Charles Ortleb's books on the dishonest science and politics of Chronic Fatigue Syndrome, HHV-6, HIV, and AIDS.   Charles Ortleb's books on Amazon   All are available in print and Kindle versions.    The Chronic Fatigue Syndrome Epidemic Cover-up which is avaialble at Amazon       Iatrogenocide Notes for a political philosophy of epidemiology and science inspired by the fraud and deceit in AIDS and Chronic Fatigue Syndrome research.       The Stonewall Massacre A provocative work of fiction that asks what would have happened is the gay movement had been totally destroyed at the Stonewall Riots.   Pig: A Memoir The Animal Farm for a new generation. A laugh-out-loud political satire about the new totalitarianism of public health.         Butterfly Ghosts Charles Ortleb's stunning first collection of poetry.       The Last Lovers on Earth   The Closing Argument Iron Peter   Silence, Exile, and Cunning   Holocaust II His play:The Black Party   His albums on Spotify (as lyricist)   Collaboration   * The Lady Upstairs   *   The Girl from Perkins Cove   *   Hey You   *   Existentialist

  In this episode, journalist Charles Ortleb reads the first chapter of Truth to Power, his paradigm-changing history of the relationship between the AIDS and Chronic Fatigue Syndrome epidemics. Charles Ortleb’s Truth to Power takes you inside the New York Native, one of the most unique and courageous newspapers of the twentieth century. Shortly after starting his small New York City newspaper in late 1980, one of the biggest scientific and political stories of our time fell into his lap in the form of the AIDS and Chronic Fatigue Syndrome epidemic. What he did with that story has secured his newspaper’s place in history. Under his guidance, a succession of intrepid journalists did some of their greatest work uncovering the crucial facts about the labyrinthine epidemic. The New York Times recently described Ortleb's early work on AIDS as "visionary." Ortleb made the decision to follow the facts wherever they led. His team of uncompromising investigative reporters inevitably stepped on the toes of the most powerful people in the medical and political establishment. Perhaps not surprisingly, the latter fought back by seeking to discredit the New York Native and even, in time, close its doors. But Ortleb stood his ground for as long as possible and as a result the world now can have a clear understanding of the relationship of AIDS, Chronic Fatigue Syndrome, and HHV-6, the transmissible virus that now threatens everyone on this planet. Truth to Power is not just a compelling work of journalism and history, but also a major contribution to the intellectual life of our time. Truth to Power has been the #1 AIDS book on Kindle for the past two weeks.   Previous episodes of Truth to Power     The Disturbing Autism and Chronic Fatigue Syndrome Connection   The mathematician who insists that the HIV story of AIDS does not add up. * The "Dediscovery" of HIV: The Australian scientists who almost destroyed the AIDS paradigm and may have inadvertently found the key to the Chronic Fatigue Syndrome epidemic.  *   The Interview with Dr. Jose Montoya, one of the world's leading Chronic Fatigue Syndrome researchers. * A discussion of Jonathan Lyon, a man with Chronic Fatigue Syndrome whose father had AIDS. Is there a connection? Will he be a better spokesperson for CFS than Laura Hillenbrand and Jennifer Brea?  * How the mistakes of CDC researcher Mary Guinan helped create the Chronic Fatigue Syndrome disaster. * Is Anthony Fauci the Bernie Madoff of AIDS and Chronic Fatigue Syndrome?  * Why are Chronic Fatigue Syndrome patients infected with the AIDS-associated Kaposi’s Sarcoma Virus? Did it come from pigs? * Chronic Fatigue Syndrome and the Centers for Disease Control's HIV Ponzi scheme.  * Are AIDS and Chronic Fatigue Syndrome the New Tuskegee Syphilis Experiment?  * An interview with Hillary Johnson, one of the world's most important Chronic Fatigue Syndrome journalists.     You can show your approval and support for this radio show by buying one or more of Charles Ortleb's books on the dishonest science and politics of Chronic Fatigue Syndrome, HHV-6, HIV, and AIDS.   Charles Ortleb's books on Amazon   All are available in print and Kindle versions. Truth to Power A new bestseller on Amazon Kindle The definitive history of the intertwined epidemics of AIDS and Chronic Fatigue Syndrome.     Iatrogenocide Notes for a political philosophy of epidemiology and science inspired by the fraud and deceit in AIDS and Chronic Fatigue Syndrome research.       The Stonewall Massacre A provocative work of fiction that asks what would have happened is the gay movement had been totally destroyed at the Stonewall Riots.       Pig: A Memoir The Animal Farm for a new generation. A laugh-out-loud political satire about the new totalitarianism of public health.       Butterfly Ghosts Charles Ortleb's stunning first collection of poetry.       The Last Lovers on Earth   The Closing Argument Iron Peter   Silence, Exile, and Cunning   Holocaust II His play:The Black Party   His albums on Spotify (as lyricist)   Collaboration   * The Lady Upstairs   *   The Girl from Perkins Cove   *   Hey You   *   Existentialist  

Charles Ortleb, the author of Truth to Power, interviews Dr. Michael J. Goldberg, the author of The Myth of Autism. Goldberg is the President of the Neuro-Immune Dysfunction Syndromes (NIDS) Medical Advisory Board and has been on the clinical teaching staff at both UCLA and Cedars-Sinai Hospitals. Dr. Goldberg has challenged the conventional wisdom about so-called "autism," arguing that it is not psychological or developmental, but a very treatable medical disease. Based on twenty-three years of treating patients, he believes there is strong evidence to show that, in its new epidemic form, what is called "autism" is actually caused by a dysfunction of the neuro-immune system and often by secondary neurotropic viruses that impact the neuro-immune system and brain. He believes that "autism" is connected to illnesses such as chronic fatigue syndrome and ADD/ADHD. Goldberg explains why he thinks it is a tragic mistake to blame vaccines for "autism" when viruses and autoimmunity seem to be the real issues.   *    Charles Ortleb is the world's first newspaper publisher and editor to take the intertwined epidemics of AIDS and Chronic Fatigue Syndrome seriously. He has become the leading expert on the political relationship between Chronic Fatigue Syndrome and AIDS. Read a free excerpt from Truth to Power, his Amazon bestseller here. His growing list of podcasts take you deep inside the dark jungle of AIDS and Chronic Fatigue Syndrome science, politics, and fraud. Click shows below to begin listening. And please come back. Here you'll find a ton of things you never knew or thought about  Previous episodes of Truth to Power     The AIDS and Chronic Fatigue Syndrome Connection   The mathematician who insists that the HIV story of AIDS does not add up. * The "Dediscovery" of HIV: The Australian scientists who almost destroyed the AIDS paradigm and may have inadvertently found the key to the Chronic Fatigue Syndrome epidemic.  *   The Interview with Dr. Jose Montoya, one of the world's leading Chronic Fatigue Syndrome researchers. * A discussion of Jonathan Lyon, a man with Chronic Fatigue Syndrome whose father had AIDS. Is there a connection? Will he be a better spokesperson for CFS than Laura Hillenbrand and Jennifer Brea?  * How the mistakes of CDC researcher Mary Guinan helped create the Chronic Fatigue Syndrome disaster. * Is Anthony Fauci the Bernie Madoff of AIDS and Chronic Fatigue Syndrome?  * Why are Chronic Fatigue Syndrome patients infected with the AIDS-associated Kaposi’s Sarcoma Virus? Did it come from pigs? * Chronic Fatigue Syndrome and the Centers for Disease Control's HIV Ponzi scheme.  * Are AIDS and Chronic Fatigue Syndrome the New Tuskegee Syphilis Experiment?  * An interview with Hillary Johnson, one of the world's most important Chronic Fatigue Syndrome journalists.     You can show your approval and support for this radio show by buying one or more of Charles Ortleb's books on the dishonest science and politics of Chronic Fatigue Syndrome, HHV-6, HIV, and AIDS.   Charles Ortleb's books on Amazon   All are available in print and Kindle versions. Truth to Power A new bestseller on Amazon Kindle The definitive history of the intertwined epidemics of AIDS and Chronic Fatigue Syndrome.     Iatrogenocide Notes for a political philosophy of epidemiology and science inspired by the fraud and deceit in AIDS and Chronic Fatigue Syndrome research.       The Stonewall Massacre A provocative work of fiction that asks what would have happened is the gay movement had been totally destroyed at the Stonewall Riots.       Pig: A Memoir The Animal Farm for a new generation. A laugh-out-loud political satire about the new totalitarianism of public health.       Butterfly Ghosts Charles Ortleb's stunning first collection of poetry.       The Last Lovers on Earth   The Closing Argument Iron Peter   Silence, Exile, and Cunning   Holocaust II His play:The Black Party   His albums on Spotify (as lyricist)   Collaboration   * The Lady Upstairs   *   The Girl from Perkins Cove   *   Hey You   *   Existentialist       Listen to "The Lady Upstairs," the album on Spotify inspired by The Chronic Fatigue Syndrome Epidemic Cover-up. Lyrics by Charles Ortleb. Music and performance by Chris Davidson. This album is also available on Amazon, Apple Music, iTunes, Google, and Deezer. Please help raise awareness about Chronic Fatigue Syndrome by including these songs on your Spotify list and by sharing them with your friends and family.  

Charles Ortleb, the author of Truth to Power, discusses Rebecca Culshaw's scathing critique of the HIV theory of AIDS. Culshaw who is an Assistant Professor of Mathematics at the University of Texas and the author of Science Sold Out, has published several journal articles about the mathematical modeling of HIV immunology. After working for a decade on HIV, Culshaw came to the conclusion that the HIV/AIDS hypothesis is untenable and the cause of a reign of terror and discrimination against the gay and black communities.   Charles Ortleb is the world's first newspaper publisher and editor to take the intertwined epidemics of AIDS and Chronic Fatigue Syndrome seriously. He has become the leading expert on the political relationship between Chronic Fatigue Syndrome and AIDS. His growing list of podcasts take you deep inside the dark jungle of AIDS and Chronic Fatigue Syndrome science, politics, and fraud. Click shows below to begin listening. And please come back. Here you'll find a ton of things you never knew or thought about.       The "Dediscovery" of HIV: The Australian scientists who almost destroyed the AIDS paradigm and may have inadvertently found the key to the Chronic Fatigue Syndrome epidemic.   *   The Interview with Dr. Jose Montoya, one of the world's leading Chronic Fatigue Syndrome researchers.   *   A discussion of Jonathan Lyon, a man with Chronic Fatigue Syndrome whose father had AIDS. Is there a connection? Will he be a better spokesperson for CFS than Laura Hillenbrand and Jennifer Brea?   *   How the mistakes of CDC researcher Mary Guinan helped create the Chronic Fatigue Syndrome disaster.   *   Is Anthony Fauci the Bernie Madoff of AIDS and Chronic Fatigue Syndrome?    *   Why are Chronic Fatigue Syndrome patients infected with the AIDS-associated Kaposi’s Sarcoma Virus? Did it come from pigs?   *   Chronic Fatigue Syndrome and the Centers for Disease Control's HIV Ponzi scheme.   *   Are AIDS and Chronic Fatigue Syndrome the New Tuskegee Syphilis Experiment?    *   An interview with Hillary Johnson, one of the world's most important Chronic Fatigue Syndrome journalists.       *       You can show your approval and support for this radio show by buying one or more of Charles Ortleb's books on the questionable science and politics of Chronic Fatigue Syndrome, HHV-6, HIV, and AIDS.   Charles Ortleb's books on Amazon   All are available in print and Kindle versions. Truth to Power The definitive history of the intertwined epidemics of AIDS and Chronic Fatigue Syndrome.     Iatrogenocide Notes for a political philosophy of epidemiology and science inspired by the fraud and deceit in AIDS and Chronic Fatigue Syndrome research.     The Stonewall Massacre A provocative work of fiction that asks what would have happened is the gay movement had been totally destroyed at the Stonewall Riots.     Pig: A Memoir The Animal Farm for a new generation. A laugh-out-loud political satire about the new totalitarianism of public health.     Butterfly Ghosts Charles Ortleb's stunning first collection of poetry.     The Last Lovers on Earth   The Closing Argument   Iron Peter His play:The Black Party           Listen to "The Lady Upstairs," the album on Spotify inspired by The Chronic Fatigue Syndrome Epidemic Cover-up. Lyrics by Charles Ortleb. Music and performance by Chris Davidson. This album is also available on Amazon, Apple Music, iTunes, Google, and Deezer. Please help raise awareness about Chronic Fatigue Syndrome by including these songs on your Spotify list and by sharing them with your friends and family.   n>

Charles Ortleb, the author of Truth to Power, discusses the arguments of the Perth Group, the Australian scientists who have been under attack from the AIDS establishment for many years for insisting that HIV was never properly isolated and that all the diagnostic tools and treatments for AIDS are based on a major scientific error. Ortleb argues that that the Perth Group has not received the credit for their major contribution because their idea about what does cause AIDS is a kind of homophobic scapegoating theory that AIDS is caused by the oxidative stress resulting from gay lifestyle issues. While they deserve credit for calling AIDS a disease that involves oxidative stress, they fail to recognize that a pandemic of virally-caused oxidative stress is being caused by the family of HHV-6 viruses which Ortleb refers to as "The Fifty Shades of AIDS Viruses." The work of French scientist Etienne de Harven is also discussed. De Harven argues that HIV is being confused with harmless endogenous retroviruses in AIDS patients. Ortleb argues that recent work shows that the other AIDS virus, HHV-6, reactivates a very harmful endogenous retrovirus called HERV-K18 which acts like a "superantigen" that can dysregulate the immune system. HERV-K18 may show that all of these scientists were on the right track but didn't see that HHV-6 was causing a much bigger epidemic than AIDS (which includes Chronic Fatigue Syndrome) and was creating confusion by introducing confounding endogenous retroviral issues. Ortleb also suggests that Dr. Jose Montoya, who hinted in a prior show that he is looking at the role of reactivated and harmful endogenous retroviruses in Chronic Fatigue Syndrome, may finally sort all of this out if he can show that a destructive endogenous retrovirus is part of the puzzle of Chronic Fatigue Syndrome. That finding could finally show that Chronic Fatigue Syndrome and AIDS are actually one variable and multisystemic epidemic of immune dysfunction.    Don't miss these fascinating previous episodes of "Truth to Power."   The Interview with Dr. Jose Montoya, one of the world's leading Chronic Fatigue Syndrome researchers.    A discussion of Jonathan Lyon, a man with Chronic Fatigue Syndrome whose father had AIDS. Is there a connection? Will he be a better spokesperson for CFS than Laura Hillenbrand and Jennifer Brea?      How the mistakes of CDC researcher Mary Guinan helped create the Chronic Fatigue Syndrome disaster.      Is Anthony Fauci the Bernie Madoff of AIDS and Chronic Fatigue Syndrome?     Why are Chronic Fatigue Syndrome patients infected with the AIDS-associated Kaposi’s Sarcoma Virus? Did it come from pigs?   Chronic Fatigue Syndrome and the Centers for Disease Control's HIV Ponzi scheme.     Are AIDS and Chronic Fatigue Syndrome the New Tuskegee Syphilis Experiment?     An interview with Hillary Johnson, one of the world's most important Chronic Fatigue Syndrome journalists.       * Like what we're doing on "Truth to Power"? To become a supporting patron of Charles Ortleb's "Truth to Power" all you have to do is buy one of these books in print or on Kindle.       Charles Ortleb's books on Amazon   Truth to Power Truth to Power exposes the truth about HHV-6, AIDS, and Chronic Fatigue Syndrome the fearless way Woodward and Bernstein exposed the truth about Watergate.   Iatrogenocide A new political philosophy of epidemiology and science inspired by the CDC's homophobic and racist separation of AIDS and Chronic Fatigue Syndrome.   The Stonewall Massacre An alternative work of history which asks if Chronic Fatigue Syndrome would have been called AIDS if the gay movement had been completely destroyed.   Pig: A Memoir The Animal Farm of our time. This novel uses satire to capture the corrupt politics of the pseudo science used to conceal the truth about Chronic Fatigue Syndrome.   Butterfly Ghosts Charles Ortleb's disturbing, funny, and provocative first collection of poetry.   The Last Lovers on Earth A collection of short stories that captures the tragedy and comedy of a gay community completely hoodwinked by public health authorities and AIDS activist trolls.   The Closing Argument A novella about the homophobic and racist politics that built the wall between AIDS and Chronic Fatigue Syndrome.   Iron Peter A novel that uses dark human and satire to warn the gay community about what the cult of AIDS activist is doing to scientific truth.   His play: The Black Party A play that makes fun of what Larry Kramer, Tony Kushner, and the AIDS activists have done to the gay community.     If you can't afford to support "Truth to Power" by buying one of these books, then please listen to Charles Ortleb's new album about Chronic Fatigue Syndrome called "The Lady Upstairs." It's on Spotify here.   Thank you for your support!  

  Charles Ortleb, the author of The Chronic Fatigue Syndrome Epidemic Cover-up, the epic account of the intertwined history, science, and politics of AIDS and Chronic Fatigue Syndrome, interviews Stanford University's Dr. Jose Montoya, a scientist who is quickly becoming the world's most celebrated Chronic Fatigue Syndrome researcher. Dr. Montoya discusses his groundbreaking new research which has identified 17 cytokines which correlate with the severity of Chronic Fatigue Syndrome. In one fell swoop, Montoya has established that Chronic Fatigue Syndrome is a real disease and one that involves serious inflammation. He also discusses his major breakthrough in treating Chronic Fatigue Syndrome. In an interview that becomes heated and contentious at times, Montoya takes issue with scientists like Judy Mikovits who describes Chronic Fatigue Syndrome as "Non-HIV AIDS." He also argues that Chronic Fatigue Syndrome is not a contagious disease in the traditional sense and he himself does not warn patients about transmitting it sexually although he does suggest it could be transmitted via blood transmission. He also makes some news at end of the interview in a tantalizing hint that he might be closing in on a possible cause of Chronic Fatigue Syndrome. In his closing remarks, Charles Ortleb argues that, ironically, Montoya has created a brilliant blood test that may actually prove that Chronic Fatigue Syndrome is transmissible and contagious when sexual and family contacts of Chronic Fatigue Syndrome patients are tested for the 17 cytokines he has correlated with the severity of Chronic Fatigue Syndrome. Learn more about Charles Ortleb's books and decades of reporting on CFS and AIDS at www.CharlesOrtleb.com Special offer for listeners of this podcast: You can purchase Charles Ortleb's The Chronic Fatigue Syndrome Epidemic Cover-up, his 466-page history of the cover-up of the politics and science of Chronic Fatigue Syndrome on Kindle here.      Some of the pages on which transmission is discussed in Hillary Johnson's Osler's Web: 187, 231, 88, 88-90, 290, 358, 376, 384, 469, 522, 327-28, 46, 87-88, 119, 132, 165, 197, 199, 228, 406-7, 465, 470, 473, 475, 512, 551, 562, 574, 644-45, 671, 61-62, 16, 629, 666-67, 329, 330, 408, 433, 57, 335-36, 88, 222, 440, 199, 201, 213, 221-22, 381, 382, 624-26.   The Doctor Who Blew the Whistle on  Chronic Fatigue Syndrome       In the April 29, 1991 issue of New York Native, there was a long interview, conducted by Neenyah Ostrom, with a very honest and outspoken doctor named Paul Lavinger. He was an internist who developed chronic fatigue syndrome in December 1989. His wife had contracted it in 1987. Ostrom reported, “In his extended household, five people now have been diagnosed with or are starting to develop symptoms of CFS. The Lavingers also have a five-year-old dog that ‘collapses for three hours’ after being taken for a walk.”      Lavinger told Ostrom, “From 25 years’ experience of practicing medicine and seeing how government agencies deal with outbreaks of illnesses, [he] believes that a ‘conspiracy of dunces’ is keeping the truth about chronic fatigue syndrome from the American public. . . . It’s absolutely ironic that the patients who have this illness, who are often turned away by physicians, are sicker than most patients in any doctor’s practice.” He also said, “The government doesn’t want to let the public know that they might be at risk, because if the public knew that they were at risk, then the public would demand certain things of the government. . . . But the government doesn’t want a public outcry. I think the government really wants to keep this quiet.”      He also believed, “The insurance companies are glad that the government doesn’t want to admit that this thing is real, because the insurance companies don’t want to have to pay.”      He also told Ostrom, “Families are in this conspiracy because they don’t want to feel guilty for not taking care of the sick family member—it’s easier to say that it’s your own damn fault. Can you imagine walking up to someone in an iron lung and saying ‘It’s your own damn fault you’re in this iron lung?’ So families absolve themselves of guilt. I know this story of a young girl with this illness: She had a typical story, there were lots of things she couldn’t do. So the family put her in a mental institution. I mean, they do this in Russia, but . . . the family doesn’t want to admit that the CFS patient is so sick that they might have to care for him or her. It’s easier to get rid of the sick person.”      Lavinger had an apocalyptic view of CFS and warned, “If you think the infrastructure of this country is the bridges, tunnels, and highways, you’re wrong—it’s the people. And I’m telling you that everybody could get sick—well, not everybody because there are people who are naturally immune to different kinds of illnesses. But it’s possible that half this country could get sick and that would be a disaster.”      In the May 6 issue of New York Native, published the second installment of the interview with Dr. Lavinger. When Ostrom asked him about the transmissibility of CFS, he said, “First of all, this disease is probably caused by a virus. Why do I say that? You know the story about the duck: If it walks like a duck, if it quacks like a duck, it’s a duck? Well if this disease isn’t a virus, it’s a duck. . . . The sheer number of people who are estimated to have CFS, as much as two to five percent of the population—maybe five to twelve million people—speaks to the issue of transmissibility. Too many people are getting the illness.”      Lavinger told her, “Practically all the people who got this disease, chronic fatigue syndrome, got it after 1980. . . . I spoke to a doctor who has been sick with CFS for six years but continues to work. In addition to his regular gastroenterology practice, out of the kindness of his heart, he takes care of 100 CFS patients. He told me that, among these 100 patients, he has 10 families. Eight of the ten families have two family members who had CFS; two of the ten families have three sick family members.”      Even though most of the evidence pointed to CFS being transmissible, he told Ostrom, “If you call the hotline at the CDC and press the right buttons on your touch-tone phone, they’ll tell you that CFS cannot be transmitted from person to person, period. And in the CDC pamphlet to doctors about this disease, it says exactly the same thing.   Learn more about transmission of CFS in hospitals here.   Learn more about the transmission of CFS between people and pets here.   Dr. Joseph Brewer on HHV-6 in CFS here.   Konnie Knox on HHV-6 in AIDS here.       Don't miss these fascinating previous episodes of "Truth to Power."     A discussion of Jonathan Lyon, a man with Chronic Fatigue Syndrome whose father had AIDS. Is there a connection? Will he be a better spokesperson for CFS than Laura Hillenbrand and Jennifer Brea?       How the mistakes of CDC researcher Mary Guinan helped create the Chronic Fatigue Syndrome disaster.       Is Anthony Fauci the Bernie Madoff of AIDS and Chronic Fatigue Syndrome?       Why are Chronic Fatigue Syndrome patients infected with the AIDS-associated Kaposi’s Sarcoma Virus? Did it come from pigs?     Chronic Fatigue Syndrome and the Centers for Disease Control's HIV Ponzi scheme.       Are AIDS and Chronic Fatigue Syndrome the New Tuskegee Syphilis Experiment?       An interview with Hillary Johnson, one of the world's most important Chronic Fatigue Syndrome journalists.       * Like what we're doing on "Truth to Power? To become a supporting patron of Charles Ortleb's "Truth to Power" all you have to do is buy one of these books in print or on Kindle.       Charles Ortleb's books on Amazon The Chronic Fatigue Syndrome Epidemic Cover-up  This book exposes the truth about HHV-6, AIDS, and Chronic Fatigue Syndrome the fearless way Woodward and Bernstein exposed the truth about Watergate.   Iatrogenocide A new political philosophy of epidemiology and science inspired by the CDC's homophobic and racist separation of AIDS and Chronic Fatigue Syndrome.   The Stonewall Massacre An alternative work of history which asks if Chronic Fatigue Syndrome would have been called AIDS if the gay movement had been completely destroyed.   Pig: A Memoir The Animal Farm of our time. This novel uses satire to capture the corrupt politics of the pseudo science used to conceal the truth about Chronic Fatigue Syndrome.   Butterfly Ghosts Charles Ortleb's disturbing, funny, and provocative first collection of poetry.   The Last Lovers on Earth A collection of short stories that captures the tragedy and comedy of a gay community completely hoodwinked by public health authorities and AIDS activist trolls.   The Closing Argument A novella about the homophobic and racist politics that built the wall between AIDS and Chronic Fatigue Syndrome.   Iron Peter A novel that uses dark human and satire to warn the gay community about what the cult of AIDS activist is doing to scientific truth.   His play: The Black Party A play that makes fun of what Larry Kramer, Tony Kushner, and the AIDS activists have done to the gay community.     If you can't afford to support "Truth to Power" by buying one of these books, then please listen to Charles Ortleb's new album about Chronic Fatigue Syndrome called "The Lady Upstairs." It's on Spotify here.   Thank you for your support!  

Would you ever consider donating your genome to research? We meet a man who has, and find out why. Plus, we get our hands dirty in the search for new antibiotics, take a look at the ethics of human gene editing, and our gene of the month is getting ahead in life. Like this podcast? Please help us by supporting the Naked Scientists

  Mary Guinan was one of the prominent early "AIDS" investigators at the Centers for Disease Control. This show explores the mistakes she made in the original epidemiology of "AIDS" that led to the mistaken separation of the "AIDS" and "Chronic Fatigue Syndrome" epidemics. This program also presents a discussion of a CDC employee named Gus Sermos who tried to blow the whistle on the shocking dishonesty of CDC AIDS researcher James Curran. Sermos was punished for trying to tell the world what was really going on at the CDC. Curran is now a celebrated Dean at Emory University.       Charles Ortleb's definitive history of AIDS and Chronic Fatigue Syndrome, The Chronic Fatigue Syndrome Epidemic Cover-up, can be purchased at Amazon. This book was formerly titled "Truth to Power."   The closing song "Hello New York, I'm back" can be heard on Spotify.   This program was orginally broacast on Progressive Radio network on Sept. 1, 2017.   Charles Ortleb's books on Amazon: The Chronic Fatigue Syndrome Epidemic Cover-up Iatrogenocide The Stonewall Massacre Pig: A Memoir Butterfly GhostsThe Last Lovers on EarthThe Closing ArgumentIron PeterSilence, Exile, and CunningHolocaust II His play:The Black Party His movie:The Last Lovers on Earth His songs and albums (with Chris Davidson) on Spotify:The Truth to Power PlaylistCollaborationThe Girl from Perkins CoveHey You His hit song about Chronic Fatigue Syndrome:The Lady Upstairs His websites:HHV-6 UniversityNew York Native University

  Charles Ortleb, the former Publisher and Editor-in-Chief of New York Native, debunks the scientific empire that has enriched Anthony Fauci and made him an iconic figure in American science and medicine. Ortleb argues that, like Bernie Madoff', Fauci has built his reputation on fraud and deceit. For at least two decades, Madoff ran a financial Ponzi scheme while Fauci has run a scientific Ponzi scheme for more than three decades. While Bernie Madoff defrauded 4,800 people out of their money, Fauci's HIV Ponzi scheme has undermined the health and civil rights of millions of people all over the world. Ortleb argues that Fauci's AIDS empire should be considered a criminal enterprise and that the AIDS-related HHV-6 epidemic (which includes Chronic Fatigue Syndrome) will only end when Fauci's HIV Ponzi scheme ends. All of Ortleb's books on Chronic Fatigue Syndrome and AIDS can be found here. Read a free book about Anthony Fauci, the Bernie Madoff of AIDS and CFS here. You can show your approval and support for this radio show by buying one or more of Charles Ortleb's books on the dishonest science and politics of Chronic Fatigue Syndrome, HHV-6, HIV, and AIDS.       Charles Ortleb's books on Amazon   All are available in print and Kindle versions. The Chronic Fatigue Syndrome Epidemic Cover-up The definitive history of the intertwined epidemics of AIDS and Chronic Fatigue Syndrome.    The Chronic Fatigue Syndrome Epidemic Cover-up Volume Two     Iatrogenocide Notes for a political philosophy of epidemiology and science inspired by the fraud and deceit in AIDS and Chronic Fatigue Syndrome research.       The Stonewall Massacre A provocative work of fiction that asks what would have happened is the gay movement had been totally destroyed at the Stonewall Riots.       Pig: A Memoir The Animal Farm for a new generation. A laugh-out-loud political satire about the new totalitarianism of public health.       Butterfly Ghosts Charles Ortleb's stunning first collection of poetry.       The Last Lovers on Earth   The Closing Argument Iron Peter   Silence, Exile, and Cunning   Holocaust II His play:The Black Party   His albums on Spotify (as lyricist)   Collaboration   * The Lady Upstairs   *   The Girl from Perkins Cove   *   Hey You   *   Existentialist  

Why are the CDC, the NIH, and the entire scientific establishment ignoring research that shows Chronic Fatigue Syndrome patients are often infected with the very destructive, cancer-causing virus that has been linked to the most dramatic symptom of the early AIDS cases, Kaposi's Sarcoma? Charles Ortleb discusses how the Kaposi's Sarcoma virus (HHV-8) may be linked to the explosive epidemic of African Swine Fever Virus (ASFV) in pigs that is now spreading in Eastern Europe and may soon reach Germany, France, and England. Ortleb discusses important unreported new evidence that African Swine Fever Virus can infect humans. He points out that Sardinia, which already has a major African Swine Fever virus epidemic in its pigs and a major epidemic of the Kaposi's Sarcoma virus in people, may hold the keys to understanding the interconnections between Kaposi's Sarcoma, Chronic Fatigue Syndrome, AIDS, and African Swine Fever. Charles Ortleb is the author of Pig: A Memoir (https://goo.gl/XEBMfC), an Orwellian novel about the politics and science of human and porcine diseases. More information about all of Ortleb's books that explore the biomedical politics of AIDS and Chronic Fatigue Syndrome are at www.CharlesOrtleb.com The closing song of this show, "Language is War," can be heard on Spotify: https://goo.gl/Fk4Hhc

In this episode, Charles Ortleb explores the similarities between the Bernie Madoff financial Ponzi Scheme and the deceitful Ponzi-like HIV science of AIDS at the Centers for Disease Control. Ortleb makes the case that the CDC's Ponzi scheme uses HIV fraud to disguise the real AIDS epidemic of HHV-6 diseases that includes the Chronic Fatigue Syndrome pandemic. He argues that the CDC's obsession with gay sex and venereal disease has basically blinded the CDC to the real nature of the AIDS epidemic. The CDC has convinced itself that AIDS is an STD when the real epidemic of HHV-6 (and its related viruses) clearly is not limited to sexual transmission. The CDC has put the health of the whole world at risk. He focuses on the work of the CDC's James Curran, one of the chief architects of the HIV/AIDS paradigm. Curran is now a celebrated Dean at Emory University. Ortleb argues that the CDC HIV Ponzi scheme will not end until the world recognizes the connection between AIDS and Chronic Fatigue Syndrome. Ortleb's books on AIDS and Chronic Fatigue Syndrome (including one on James Curran) can be found at www.charlesortleb.com.   You can be a supporter of these podcasts by buying a copy of The Chronic Fatigue Syndrome Epidemic Cover-up at Amazon. 

Charles Ortleb, the New York Native publisher who made his newspaper the paper of record on AIDS and Chronic Fatigue Syndrome, explores the similarities between the racist politics and deceptions of AIDS, Chronic Fatigue Syndrome, and the Tuskegee Syphilis Experiment. The author of the first book on the racist politics and science of AIDS and Chronic Fatigue Syndrome (The Closing Argument https://goo.gl/LPkytF ) attempts to explain why Peter Duesberg--the molecular biologist who debunked the science of HIV--was not able to bring down the AIDS establishment's house of cards. Why wasn't Peter Duesberg as successful as Peter Buxtun, the man who was credited with ending the Tuskegee Syphilis Experiment? Why haven't Peter Duesberg's cogent arguments against the HIV theory of AIDS opened up an international inquiry into the role of HHV-6 in AIDS and the disturbing connections between the AIDS and Chronic Fatigue Syndrome epidemics? All of Charles Ortleb's books are at www.charlesortleb.com

Charles Ortleb, the publisher of New York Native and author of The Chronic Fatigue Syndrome Epidemic Cover-up, interviews Hillary Johnson, the first journalist to cover the Chronic Fatigue Syndrome epidemic in Rolling Stone. She is also the author of Osler's Web: Inside the Labyrinth of the Chronic Fatigue Syndrome Epidemic. Visit her website Oslersweb.com for all her latest reporting. All of Charles Ortleb's books about HHV-6, Chronic Fatigue Syndrome, AIDS and the politics of science can be found at CharlesOrtleb.com.     Listen to "The Lady Upstairs," the album on Spotify inspired by The Chronic Fatigue Syndrome Epidemic Cover-up. Lyrics by Charles Ortleb. Music and performance by Chris Davidson. This album is also available on Amazon, Apple Music, iTunes, Google, and Deezer. Please help raise awarness about Chronic Fatiue Syndrome by including these songs on your Spotify list and by sharing them with your friends and family.  

While there is some understanding of herpes today, there is much more to know for true healing to occur. Listen to this Medical Medium Radio Show to learn about the different varieties of herpes such as Cytomegalovirus, Simplex 1, Simplex 2, Epstein Barr Virus, Shingles, HHV-6, & HHV-7 and learn practical tips for how to begin healing.

Voice introduction I was having a discussion the other day with the mom of one of my patients. She was asking me why we vaccinate children against chickenpox; a disease that her mother told her was a benign mild childhood illness that doesn't hurt kids.  Keep in mind that almost none of the parents of my current patients have ever seen or had any experience with the disease of chickenpox.  The disease is virtually gone in the United States so everything parents know today is based on what they have heard.  This particular mom had so many questions and a few misconceptions about chickenpox. Because of this I thought many of my blog listeners probably have many of the same questions, so today were going to talk about the disease known as chickenpox: the myths and facts and the rationale behind vaccinating today's children. Why do we bother vaccinating for a harmless childhood illness? Music introduction The biology of chickenpox Let's start with the basics. Chickenpox is caused by a herpes virus that goes by few names:  Varicella, herpes zoster, and  HHV-3 or human herpes virus type three. It's very contagious, one of the most contagious diseases ever known to exist.  In fact, it can spread airborne up to 7 feet, which means that Just being in the same room with someone who has chickenpox can spread the disease to the others in the room. No touch is needed.  The rash itself looks a lot like it's deadly cousin, smallpox.  Fortunately smallpox has been eradicated from earth since the 1970's since it is a deadly infection in both adults and children.   Chickenpox however is usually a relatively mild illness for most kids so my patient's mom was correct on that point. In fact when I was a child it was common for Mom's to have a chickenpox parties when there was an active case in the neighborhood so that all the kids would go ahead and get exposed and get the disease out of the way. It was just considered a right of passage to have chickenpox.  Spring was the big season for chickenpox for some reason. So why do we go to all the expense of vaccinating children against what's usually such a mild disease. Well there are two reasons.  The first is that there were deaths from chickenpox years ago the illness was common. Usually a child got chickenpox and then got a nasty strep or staph infection on top of some of there open sores. This could be lethal. Remember the flesh eating strep?  Germs like this love all the broken skin chickenpox creates. Death from natural chickenpox happened 150 times per year in the United States before we start vaccinating in children 1995.  But 11,000 children a year ended up in the hospital secondary to complications from the chickenpox in the US alone, many with life threatening complications such as encephalitis, an often fatal liver disease called Reyes syndrome, pneumonia, or just good old dehydration. Chickenpox can be a very frightening disease. The second reason we vaccinate children today is a little more complicated to understand. You need to understand that everyone who gets infected with any chickenpox virus harbors this herpes virus for the rest of his or her life, an infectious disease time bomb so to speak. In the short run, the virus becomes dormant, hanging out silently for decades in the nervous system of anyone who has had chickenpox. But weaken that person's immune system with age, sickness, or stress, and it can spring right back out as a disease known as shingles. You've heard about that old age disease shingles. Remember, shingles and chickenpox are caused by the same virus. Chickenpox is the form of the disease that is systemic, in the blood, and everywhere. A child gets chickenpox on their initial exposure to the chickenpox virus. If the virus reactivates in a localized area we call that shingles and that's a serious health problem for older folks. You probably have heard that children can get chickenpox from touching someone shingles if they've never had chickenpox.

1) Time from convulsive status epilepticus onset to anticonvulsant administration in children and 2) Topic of the month: Voices of encephalitis. This podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. John Mytinger interviews Dr. Tobias Loddenkemper about his paper on time from convulsive status epilepticus onset to anticonvulsant administration in children. Dr. James Addington is reading our e-Pearl of the week about cannabis in epilepsy. In the next part of the podcast Dr. Lara Marcuse interviews Stephen Haslett about the topic of herpes simplex virus encephalitis. The participants had nothing to disclose except Dr. Loddenkemper and Addington.Dr. Loddenkemper performs video EEG long term monitoring, EEGs and other electrophysiological studies at Boston Children's Hospital (20% effort); evaluates pediatric neurology patients; serves on the Laboratory Accreditation Board for Long Term (Epilepsy and Intensive Care Unit) Monitoring, on the Council of the American Clinical Neurophysiology Society, on the American Board of Clinical Neurophysiology; serves as an Associate Editor for Seizure serves as Contributing Editor for Epilepsy Currents; serves as an Associate Editor for Wyllie's Treatment of Epilepsy 6th edition; is part of pending patent applications to detect seizures and to diagnose epilepsy; receives research support from the American Epilepsy Society, the Epilepsy Foundation of America, the Epilepsy Therapy Project, PCORI, the Pediatric Epilepsy Research Foundation, Cure, Danny-Did Foundation, HHV-6 Foundation, Lundbeck Inc., Eisai Inc., and Upsher-Smith Laboratories, Inc.Dr. Addington serves on the editorial team for the Neurology® Resident and Fellow Section.

[intro music]  Host – Dan Keller   Hello, and welcome to Episode Four of Multiple Sclerosis Discovery, the Podcast of the MS Discovery Forum. I’m your host, Dan Keller.  This week’s Podcast features an interview with Dr. Michael Racke about the potassium channel Kir4.1 and its potential role in MS. But to begin, here’s a brief summary of some of the topics we’ve been covering on the MS Discovery Forum at msdiscovery.org.    Researchers at the University of California San Francisco have developed a new remyelination assay that allows high through-put drug screening. The assay takes advantage of oligodendrocyte’s tendency to wrap myelin around anything axon-shaped, such as plastic fibers and microscopic glass pillars. The assay has already identified several FDA-approved drugs as candidates for remyelination therapies, including an over-the-counter antihistamine now in phase II clinical trials.   In another article, we report on a new study that sheds light on the ameliorating effect of ultraviolet rays on inflammation and disease progression in mouse models of MS. In the study, MS patients sat in a therapeutic UV chamber for five sessions a week for six weeks. Even after one session, the patients had an increase in dendritic cells and regulatory T-cells. In follow-up studies with EAE mice, the researchers uncovered a possible mechanism by which these regulatory T-cells migrate to the central nervous system.   In addition to covering the latest in MS research, the MS Discovery Forum also curates news stories from around the web in our twice-weekly Research Roundup. Last week we wrote about the findings in phase III trials of daclizumab, a legal dispute between drug companies Acorda and Actavis, and a new collection of immunology papers from the journal PLOS. We also posted some social media advice as well as the amusing hashtag #yomanuscipt. Our favorite tweet: Yomanuscript is so bad the null hypothesis rejected it. Check out Research Roundup under the news brief section in the News and Future Directions tab on our website.   [transition music]   Now to the interview. Dr. Michael Racke is the Chair of the Department of Neurology at the medical school at Ohio State University. He’s here to discuss the latest findings of the potassium channel known as Kir4.1 and its implications for MS. MS Discovery’s Executive Editor, Bob Finn, spoke with Dr. Racke.    MSDF Dr. Racke, welcome. Dr. Racke Thanks.  MSDF So what is Kir4.1? Dr. Racke   So Kir4.1 is a what’s called a potassium inward rectifying channel that’s expressed on the end-feed of astrocytes and also on oligodendrocytes. And so it’s important for trying to adjust the right concentration of potassium in and outside of a cell.  MSDF   And what is its relationship to MS? Dr. Racke   Well, there’s been a lot of interest recently. There was a paper published in the New England Journal now almost a year and a half ago, I believe, from Bernhard Hemmer’s group that showed that about 50% of MS patients have antibodies directed against this potassium channel, Kir4.1. MSDF   And is that a lot more than people without MS? Dr. Racke   Right. So when they looked at healthy individuals or looked at patients with not just neuroimmunologic diseases but also other non-inflammatory diseases, the number of antibodies directed against it was very low, on the order of magnitude of like 3%.  MSDF   So what does this mean for our research in MS?  Dr. Racke   You know, for a long time people have been interested in what are the potential targets, and this would represent a little bit different target than the typical myelin proteins that one has thought of as being targets in MS. It’s also kind of interesting because of another molecule, aquaporin 4, that is expressed in the same place in the astrocytic endfeet that’s been the antibody target for neuromyelitis optica. And so I think as we begin to see responses against some of these other molecules, it’s interesting to see whether they result in in demyelination and whether that can be a new avenue for therapeutic intervention.  MSDF   Just within the last week, another study came to a quite different conclusions regarding the prevalence of Kir4.1 autoantibodies in MS. How do you resolve the discrepancy? Dr. Racke   There was data presented yesterday to suggest that one of the differences may actually be differences in glycosylation of Kir4.1. It turns out that eukaryotes—and humans are eukaryotes obviously—glycosylate proteins, and that very often glycosylated protein looks very different to the immune system than an unglycosylated protein. And since a lot of these studies take an unusual cell type and then try to over-express to your 4.1 on its surface and then see whether an antibody recognizes it, it may not be the same type of glycosylation that’s actually seen within patients with MS. MSDF   There’s a lot of research going on now on Kir4.1. What more needs to be done in this area before Kir4.1 becomes a therapeutic target?  Dr. Racke   Right. Well, so, for example, if you look at neuromyelitis optica, that if you did plasmic change in those patients, then very often those patients are benefited. So it’s as though if I take away those antibodies the patient does be better, so those antibodies are pathogenic. When that’s been done in MS, the data, it’s sort of been, I don’t want to say controversial, but in some sense it is. And then there have been studies, for example, done from the Mayo Clinic that looked in at certain types of demyelinating events where it seemed like plasma exchange did work, then there were larger studies that were done and it didn’t seem to work. And if, in fact, it’s, say, a pa a patient population where really only one-third to half of the patients have the pathogenic antibody, then if I do that study and say I’m going to do it to everybody, it may not have enough power to suggest that there’s efficacy for everybody. But I think it gets back also to this idea of what a lot of people talk about in personalized medicine, right, and the idea may be that you would be able to identify patients that perhaps had an antibody to Kir4.1, and then perhaps they would be more amenable to therapeutic interventions that targeted antibody synthesis in the blood. MSDF   Do you think that interventions targeted at Kir4.1, would that would it work much the same way as other as existing therapies in decreasing the number of relapses in re relapsing-remitting MS? Dr. Racke   For example, if you look at things like interferon, natalizumab, the way those therapies are trying to work isn’t against the specific antigen, right. What they’re really trying to do is just interrupt the disease process. And I think the difference is going to be there have been some studies where people were trying to target the specific epitopes to either myelin basic protein – the altered peptide ligand studies were like that – and there’s studies now also where people have solubilized MHC molecule that has a myelin peptide on it. And those are specifically trying to target the immune response against a very specific antigen. Now I have to say that most of those things haven’t really worked very well, and I think part of the reason is that the human immune response is complicated enough, but by the time a person has had several attacks in MS, they probably are making an immune response against a number of myelin antigens, and so if I target just a single antigen it may not work. And that may also end up being true in in terms of Kir4.1, that it’s just going to be another thing. But, I mean, if there’s enough similarities between it and some of the things that we’ve seen with neuromyelitis optica in aquaporin 4, like I say, there the plasma exchange and targeting the B-cell response in many instances has been quite beneficial to pa patients, right. And so I think that’s going to be an important next step to not just demonstrate that it can be part of the target that happens in multiple sclerosis, but whether inhibiting that response to that target actually has therapeutic benefit.    MSDF   You just outlined one area of research on Kir4.1 that needs to go forward. What are some others? Dr. Racke The other issues have to do with trying to understand exactly the cell-type specificity in terms of glycosylation, trying to understand why is it that this particular channel is a target in MS, then are other channels also targets in MS. This sort of opens up a whole other ballgame in terms of diversity of targets that could potentially participate in MS pathogenesis. MSDF   Is there anything else you’d like to add about Kir4.1 that we haven’t already talked about? Dr. Racke   I’ve been in this field for 20 years, and realistically this has been the first new antigen that really has come up. And that’s sort of interesting in and of its own right. I think the other thing, obviously, for those people who are interested in things like molecular mimicry, this gives you another molecule to begin to look at in terms of its sequence homology with infectious agents. I mean, the people who are interested in, you know, viruses like HHV-6 and Epstein-Barr viruses, and those that they think that have an important role potentially in MS pathogenesis, how might infections with those agents affect Kir4.1 expression. That’s going to be another area that’ll be of interest to the research community in MS. MSDF   Well, Dr. Racke, thank you very much.  Dr. Racke   You’re welcome.  [transition music]   Thank you for listening to Episode Four of Multiple Sclerosis Discovery. This Podcast was produced by the MS Discovery Forum, MSDF, the premier source of independent news and information on MS research. MSDF’s executive editor is Robert Finn. Msdiscovery.org is part of the nonprofit Accelerated Cure Project for Multiple Sclerosis. Robert McBurney is our President and CEO, and Hollie Schmidt is Vice President of Scientific Operations.    Msdiscovery.org aims to focus attention on what is known and not yet known about the causes of MS and related conditions, their pathological mechanisms, and potential ways to intervene. By communicating this information in a way that builds bridges among different disciplines, we hope to open new routes toward significant clinical advances.    We’re interested in your opinions. Please join the discussion on one of our online forums or send comments, criticisms, and suggestions to editor@msdiscovery.org.    [outro music]  

LAQUITA HENRY, Project Manager of the Heritage Heights Village (HHV) Commercial Revitalization Initiative (Heritage Health and Housing, Inc.) and JOHN REDDICK, Architectural Consultant and Curator for the Amsterdam Avenue Streetscape Exhibit join Audrey in the WHCR studio to discuss the HHV's initiative to provide economic development opportunities in the Hamilton Heights/ Sugar Hill districts.

LAQUITA HENRY, Project Manager of the Heritage Heights Village (HHV) Commercial Revitalization Initiative (Heritage Health and Housing, Inc.) and JOHN REDDICK, Architectural Consultant and Curator for the Amsterdam Avenue Streetscape Exhibit join Audrey in the WHCR studio to discuss the HHV's initiative to provide economic development opportunities in the Hamilton Heights/ Sugar Hill districts.

Die Reaktivierung von Herpesviren, wie EBV, CMV und HHV-6, kann bei Patienten nach einer allogenen Stammzelltransplantation zu schwerwiegenden Erkrankungen und sogar zum Tod führen. Zur Behandlung von EBV- oder CMV-assoziierten Komplikationen hat sich in der Vergangenheit der adoptive Transfer von virusspezifischen T-Zellen, die aus dem T-Zellgedächtnis des Stammzellspenders isoliert wurden, als wirksam und gut verträglich erwiesen. Patienten mit einem CMV-negativen Transplantatspender haben ein erhöhtes Risiko für CMV-assoziierte Erkrankungen, und gerade in diesem Fall fehlt eine adoptive Therapie, weil CMV-spezifische T-Zellen von einem solchen Spender nicht verfügbar sind. Um dieses Problem zu lösen, habe ich in meiner Arbeit die Herstellung von CMV-spezifischen T-Zellen mittels retroviralem Transfer des spezifischen T-Zellrezeptors untersucht. Zuerst habe ich CD4+ und CD8+ T-Zellklone mit verschiedenen HLA-Restriktionen, die die endogen prozessierten und präsentierten CMV-Antigene pp65 und IE-1 erkennen, aus dem T-Zellgedächtnis von CMV-positiven Spendern generiert und charakterisiert. Für den retroviralen Transfer wurden vier pp65-spezifische T Zellrezeptoren unterschiedlicher HLA-Restriktionen ausgewählt. Die Gene der TCRs wurden kloniert und auf primäre T-Zellen CMV-negativer Spender übertragen. CMV-TCR-transgene T Zellen zeigten ein breites Spektrum an wichtigen Effektorfunktionen wie die Freisetzung von IFN-γ und IL 2 sowie Zytotoxizität und Proliferation gegenüber endogen prozessiertem pp65, und die Zellen konnten durch strikt antigenspezifische Stimulation angereichert und expandiert werden. Die Expansion der TCR-transgenen Zellen war von einem Anstieg der spezifischen Effektorfunktionen begleitet, was zeigt, dass die übertragene Spezifität stabil und voll funktionsfähig war. Deshalb erwarte ich, dass diese CMV-TCR-transgenen T-Zellen sich für die effektive Kontrolle einer akuten CMV-Infektion eignen und darüber hinaus für ein antivirales Gedächtnis sorgen werden. Auch die Reaktivierung von HHV-6 führt in immunsupprimierten Patienten zu ernsthaften Erkrankungen. Leider ist es allerdings bisher nicht möglich, HHV-6-spezifische T Zellen für den adoptiven Transfer herzustellen, weil die Antigene und Epitope der HHV-6-spezifischen Immunantwort nicht bekannt sind. Durch die Stimulation mit Peptiden aus den HHV-6-Tegumentproteinen U11 und U54, die aufgrund von konservierten HLA-Bindungsmotiven als CD8-T-Zellepitope vorhergesagt wurden, ist es mir gelungen, HHV-6-spezifische CD8+ T-Zellen von gesunden Virusträgern in vitro anzureichern. Ich konnte T-Zellklone spezifisch für mehrere HLA-A*0201-restringierte Epitope herstellen: die U11-Peptide GIL, MLW und SLM sowie die U54-Peptide ILY und LLC. Ich zeigte, dass ILY und LLC bei der intrazellulären Antigenprozessierung entstehen. ILY-spezifische T-Zellen erkannten virusinfizierte Zellen in vitro. Damit habe ich die ersten CD8-T Zellepitope von HHV-6 charakterisiert und gezeigt, dass sich auch die HHV-6-spezifische T Zellantwort, ähnlich wie die CMV-spezifische, gegen virale Tegumentproteine richtet. Durch Multimerfärbung von peripheren Blutzellen konnte ich zeigen, dass diese HHV-6-spezifischen T Zellen im T-Zellgedächtnis gesunder Virusträger im Vergleich zu anderen herpesvirusspezifischen T-Zellen selten sind. Diese Erkenntnisse liefern eine Grundlage für weitere Untersuchungen des HHV-6-spezifischen T-Zellrepertoires und helfen, Strategien für die Herstellung von HHV-6-spezifischen T-Zellen für die Immuntherapie zu entwickeln.

On episode #73 of the podcast This Week in Virology, Vincent, Dickson, and Rich discuss multipotent progenitor bone marrow cells as a reservoir of HIV-1, integration of HHV-6 into telomeres, and dispersal of West Nile virus across the US by mosquitoes. Host links Vincent Racaniello, Dickson Despommier, and Rich Condit Links for this episode: HIV-1 infects multipotent progenitor cells HHV-6 genome integrates into telomeres A role for mosquito-mediated dispersal of West Nile virus across the US Using tobacco mosaic virus to produce synthetic photovoltaic cells (thanks Nissin!) Animation of HIV replication cycle (thanks Ilya!) Can computer viruses evolve? (thanks Norman!) Mumps outbreak in Israel (one and two) (thanks Ariel!) Bocavirus infections in children (thanks Tyler!) Weekly science picks: Dickson Whole-Genome Sequencing in a Patient with Charcot–Marie–Tooth Neuropathy (NEJM and NY Times) Rich Invisible Frontiers: The Race to Synthesize a Human Gene by Stephen Hall Vincent Conference on Retroviruses and Opportunistic Infections - videocasts

Continuing our discussion of all the things we do that bring on illness in our society. In this episode we talk about: 1. Don't breast feed your baby. Mothers, consider breastfeeding your children if you don't want them to risk the trauma of numerous childhood diseases and if you don't want to pay the hospital bills. It will also reduce your risk of developing breast cancer by 25 percent, and it may lower the risk of postpartum depression! Mother's milk contains cells that attack harmful bacteria in the baby's system, and it is able to form antibodies that destroy invading viruses as well. Mother's milk is the Maker's perfect food for babies, delivered in the close bonds of maternal intimacy.10 2. Get tattoos. Scripture warns against piercing the skin. (See Leviticus 19:28.) Body piercing and tattoos can easily introduce potentially deadly infections and toxic foreign substances into the body and bloodstream. Some health providers warn that even tiny puncture wounds might block important electrical nerve impulses just under the skin. 3. Get all of your immunization shots. Despite massive media and government public relations campaigns to the contrary, certain childhood immunization injections may pose considerable risks to children. Most adults today received one to five immunizations in childhood, but schoolchildren today receive an average of twenty-two or more immunizations-most of them administered while the brain and nervous system are still developing! An epidemic of juvenile autism and other neurological and developmental disorders sweeping through America's school-age children generally coincides with the introduction of certain mandatory immunizations. A growing body of scientific and medical research appears to link this dangerous health trend to these childhood immunizations. Vijendra K. Singh, Ph.D., an eminent neuroimmunologist from the Department of Biology and Biotechnology Center at Utah State University, hypothesized in research published internationally "that a measles virus-induced autoimmune response is a causal factor in autism, whereas HHV-6 via co-infection may contribute to pathophysiology of the disorder. Although as yet unproven, I think it is an excellent working hypothesis to explain autism, arid it may also help us understand why some children show autistic regression after the measles-mumps-rubella (MMR) immunization.11 Dr. Singh's findings seem to Confirm the results of a similar study published in the Lancet in 1998 by Dr. Andrew Wakefield and co-workers of the Royal Free Hospital in London, indicating a possible link between MMR vaccination, Crohn's disease of the bowel, and autism.12 Most states allow philosophical and religious exemptions from mandatory immunization programs should you decide this is the way to go. 4. Travel in airplanes often. Some people who spend a lot of time at high altitudes experience problems with infertility and oxygen production in the body. The body adapts well to high altitudes for short periods of time, but not for long periods. Animals dwelling at heights of thirteen to fourteen thousand feet have much more difficulty conceiving and instinctively return to lower pastures for breeding. Some researchers believe the atmospheric pressures and radiation to which airplane travelers are exposed are the equivalent of hundreds of CAT scans and pose the greatest oxidative stress on the human body.13 (Who wants to be trapped in a small room with hundreds of sneezing, coughing people?) Each week Martin Pytela and Scott Paton discuss Holistic principles for healthy living. Life Enthusiast Co-op is built on over 25 years in study, health consultations and market research in the field of holistic and alternative medicine. We deliver solid time tested expertise. We are in this business not for the money, but for the passion, we have for sharing with others what we had to learn the hard way, through experience. We focus on high quality, innovative holistic solutions. Length: 24:51 Go to iTunes and review our podcast: iTunes Life Enthusiast Reviews and 5 star ratings If You Enjoyed This, Please Go To "FANS OF THIS SHOW" On The RIGHT And Then Click On "BECOME A FAN". In Addition, PLEASE CLICK On The “SEND TO A FRIEND” At The Bottom Of This Podcast…. COPY THE DATA And SEND THIS, and “My Pod Home Page URL”, To EVERYONE In Your ADDRESS BOOK…. FRIENDS Or ENEMIES! WANT TO BE NOTIFIED OF NEW EPISODES? ~~~~~~~~~~~~~~~~~~~~ Go To “Join my mailing list ” On The RIGHT………. When It Comes Up You Will See On This Page “Add me to Life Enthusiast''s mailing list:” ………. And Then type in your name and email address ………. Now Just Click “Save”. Technorati Tags: weight loss, Diet, Obesity, Dieting, Healthy Living,Food, Exercise, Fitness, Nutrition, Supplements, Lose Weight, Martin Pytela, Scott Paton.

Das Humane-Herpesvirus-8 (HHV-8) gehört zu den Viren, die an der Entstehung von humanen Tumoren beteiligt sind. Die zugrunde liegenden onkogenen molekularen Mechanismen sind weitgehend unbekannt. Mit Hilfe der Arraytransfektion soll eine HHV-8-Expressionsbank auf die Induktion von mit HHV-8 assoziiert bekannten Transkriptionsfaktoren untersucht werden. Dabei wurde ein modulares Reportersystem entwickelt, das die Transkriptionsaktivierung von AP-1, NF?B und p53 in der Arraytransfektion erfassen kann. Durch das Reportersystem konnte mit Hilfe der Arraytransfektion die HHV-8-Thymidinkinase als den Transkriptionsfaktor p53 induzierend ermittelt werden. Die lytisch assoziierte HHV-8-Thymidinkinase konnte in zwei funktionell getrennte Domänen unterteilt werden. Einerseits in die bekannte C-terminale Domäne mit der biochemischen Kinasefunktion und andererseits in eine neu beschriebene N-terminale Domäne. Diese ca. 200 Aminosäuren lange N-terminale Proteindomäne war allein dafür verantwortlich, dass das endogene p53-Proteinlevel erhöht, p53 als Transkriptionsfaktor induziert und p53 an Serin-392 phosphoryliert wurde. Durch das anti-apoptotische HHV-8-Protein "latency-associated nuclear antigen" (LANA) 2 ließ sich die Transkriptionsaktivierung von p53 durch die HHV-8-Thymidinkinase inhibieren, aber nicht vollständig aufheben. Dadurch konnte gezeigt werden, dass die HHV-8-Thymidinkinase-Wirkung durch ein anderes HHV-8-Gen auf molekularer Ebene reguliert wird. Darüber hinaus war die N-terminale Domäne für die Veränderung der Zellmorphologie zu Zellinseln, Verminderung der Zellzahl und wahrscheinlich für die Depolarisation des mitochondrialen Potentials verantwortlich. Zusätzlich konnte in lytisch induzierten BCBL-1-Zellen gezeigt werden, dass das Transkriptionsverhalten der HHV-8-Thymidinkinase durch das viral-replikationsinhibierende Ganciclovir, in Abhängigkeit von der Inkubationsdauer, wahrscheinlich wenig oder gar nicht beeinflusst wird. Es ist daher zu vermuten, dass die HHV-8-Thymidinkinase das durch Ganciclovir nicht transkriptionsinhibierbare HHV-8-Gen ist, das durch die Umgehung viraler und zellulärer anti-apoptotischer molekularer Mechanismen den Zelltod in lytisch induzierten BCBL-1-Zellen auslösen kann. Diese Einflüsse einer Thymidinkinase sind für die humanen Gammaherpesviren einmalig und konnte für das homologe Gen des Epstein-Barr-Virus nicht beobachtet werden. Durch wahrscheinlich unterschiedliche subzelluläre Lokalisierungen wurde die Divergenz in der Funktion zusätzlich aufgezeigt. Die ermittelten Erkenntnisse dieser Arbeit können zur Entwicklung einer anti-viralen Therapie beitragen, die die lytische Vermehrung von HHV-8 begrenzt und somit die Entstehung von HHV-8 abhängigen Tumoren, wie das Kaposi-Sarkom, verhindern könnte. Zusätzlich gibt der Einfluss der HHV-8tk auf die Wirtszelle einen Einblick in die Interaktion des Virus mit dem Wirt und erlaubt wichtige Rückschlüsse auf das Zusammenspiel zellulärer und viraler molekularer Mechanismen für die Grundlagenforschung.

Bei dem Kaposi-Sarkom (KS) handelt es sich um eine eng mit dem Humanen-Herpes-Virus 8 (HHV 8) assoziierte vaskuläre Neoplasie. Die Etablierung eines kommerziell erhältlichen, stabilen Antikörpers gegen das virale „Latenz-assoziierte-nukleäre Antigen“ (LANA) von HHV 8 ermöglicht den Nachweis HHV-8-infizierter Zellen an Ex-vivo- Paraffinmaterial. In dieser Arbeit wird diese Methode an einem Kollektiv aus insgesamt 61 Patienten mit HIV-assoziiertem KS angewendet, um einen Beitrag zur Beantwortung von bislang ungeklärten Fragen nach der quantitativen Verteilung von HHV 8 im Organismus und zur formalen Pathogenese des KS zu leisten. Das Kollektiv besteht aus diagnostischen Exzisaten (20 Früh- und 20 Spätstadien des KS) sowie aus 21 Sektionsfällen mit KS wovon Lympknoten, Leber-, Milz- und Lungengewebe untersucht wurden. Durch die Etablierung und Auswertung technisch aufwendiger immunhistochemischer Doppelfärbeexperimente mit dem viralen Protein LANA und verschiedenen strukturellen und regulatorischen Humanproteinen (CD31, CD34, Ki67 und p21) sowie durch die Anpassung des LANA-Nachweises an Autolyse- bzw. Sektionsmaterial kommen wir in der vorliegenden Arbeit zu folgenden Ergebnissen: Die KS-Progression geht von der Proliferation nicht-infizierter Zellen aus. Dies spricht für ein parakrin-stimuliertes KS-Wachstum und stützt Hypothesen, die das KS als viral-getriggerte, reaktive Angioproliferation einstufen. Außerdem unterscheidet dieser Befund das KS von dem ebenfalls HHV-8-assoziiertem „Primären Effusions Lymphom“ (PEL), dessen Progression ein autonomer Zellzyklus zugrunde liegt. Weitere Ergebnisse dieser Arbeit stützen die mittels In-vitro-Experimenten von Wang et al. aufgestellte Hypothese, dass HHV 8 das Expressionsmuster der infizierten Zellen in Richtung der endothelialen Vorläuferzelle verändert. Durch Koexpressionsexperimente mit Endothelzellmarkern kann außerdem gezeigt werden, dass die HHV-8-infizierten Zellen an der Gefäßbildung im KS direkt beteiligt sind. Schließlich lassen sich im Sektionsmaterial HHV-8-infizierte mononukleäre Zellen in mehreren Organen als disseminierte Einzelzellen außerhalb der klinisch/makroskopisch sichtbaren KS-Läsionen nachweisen, und es finden sich mikroskopisch kleine KS-Frühstadien. Der bisher nur in vitro durch den Nachweis von HHV-8-infizierten Zellen im Blut vermutete formalpathogenetische Weg, wonach HHV-8-infizierte mononukleäre Zellen zur Infektion der endothelialen KS- „Zielzellen“ beitragen, wird somit ex vivo an dem Untersuchungskollektiv histomorphologisch belegt.