Podcast appearances and mentions of hans krebs

En el episodio "Maravillas del metabolismo" de Natural Born Curious, Kirén y Cristian se adentran en el apasionante tema del metabolismo humano, grabando en vivo frente a una audiencia. Cristian, compartiendo su entusiasmo por el tema, explica que el metabolismo es la serie de reacciones bioquímicas que permiten la vida, abarcando la transformación de alimentos en energía, la síntesis de biomoléculas y la eliminación de desechos.La conversación se enriquece con anécdotas históricas sobre el metabolismo, desde la antigua Grecia hasta los estudios científicos modernos, destacando figuras como Santorio Santorio y Hans Krebs. La interacción con el público realza el episodio, haciendo que la ciencia sea accesible y entretenida.El programa aborda también las epidemias silenciosas como la diabetes y los trastornos de tiroides, poniendo de manifiesto su prevalencia y las controversias en el diagnóstico y tratamiento. El tema de la innovación tecnológica se presenta como un rayo de esperanza, señalando cómo el big data, la inteligencia artificial y los relojes inteligentes están transformando nuestra comprensión y manejo del metabolismo.Cerramos con una visión optimista del futuro de la investigación del metabolismo, donde las tecnologías emergentes prometen revoluciones en el cuidado de la salud y un mayor entendimiento de los procesos biológicos.Facebook/MerckMexico

Welcome to the Instant Trivia podcast episode 568, where we ask the best trivia on the Internet. Round 1. Category: Yangtze Doodle 1: The Grand Canal connects the Yangtze River to this other major river. the Yellow River. 2: The 2 rivers in the world that are longer than the Yangtze. the Amazon and the Nile. 3: The Yangtze flows through this province that's China's most populous and known for its spicy cuisine. Szechuan. 4: Native to the Yangtze river valley, this fruit is also known as a Chinese gooseberry. a kiwi. 5: This dam, one of the world's largest when completed, is being built on the Yangtze to control flooding. the Three Gorges Dam. Round 2. Category: Men And Women Of Science 1: In the 1930s this California transplant posthumously received plant patents No. 12-16. Luther Burbank. 2: In 1925 this American anthropologist first visited Samoa; she wrote a book about it 3 years later. Margaret Mead. 3: In 1909, after 7 years with the Swiss Patent Office, he became a professor at the University of Zurich. Albert Einstein. 4: In the 1870s this French chemist demonstrated that anthrax was caused by a particular bacillus. Pasteur. 5: The "Hans"-on work of this biochemist born in 1900 unraveled the mystery of the citric acid cycle. Hans Krebs. Round 3. Category: Medical Milestones 1: Louise Brown, the first human conceived by in vitro fertilization, is better known as the 1st this "baby". test tube baby. 2: In 1853 Charles Gerhardt buffered salicylic acid, creating acetylsalicylic acid, later marketed as this. aspirin. 3: This type of surgery introduced in 1961 uses extreme cold to perform a "bloodless" operation. cryogenic (or cryosurgery). 4: In 1977 the balloon type of this procedure was used for the first time to unblock clogged heart arteries. angioplasty. 5: In 1866 Dr. Thomas Allbutt was all brain when he invented a 6-inch one of these; safer fluids have replaced mercury. a thermometer. Round 4. Category: Music Of The '70s 1: In 1973 Bette Midler revived this Andrews Sisters hit, reaching the Top 10. Boogie Woogie Bugle Boy. 2: This "Diana" singer wrote Tom Jones' 1971 hit "She's A Lady". Paul Anka. 3: His "52nd Street" was the No. 1 album of 1979. Billy Joel. 4: This James Taylor hit is subtitled "To Be Loved by You". How Sweet It Is. 5: In 1973 he won a Grammy for Best Country Song for "Behind Closed Doors". Charlie Rich. Round 5. Category: Politics 1: Cities as big as L.A. and Dallas have this kind of mayoral election where there's no "D"' or "R" after the candidates' names. nonpartisan. 2: In 1913 James Hamilton Lewis became the first senator in this job of counting votes and rounding up members. whip. 3: Military-sounding term for a local leader who oversees a political party's activities in one precinct. a captain. 4: The rooster was symbol of this party before Thomas Nast drew their new one in 1870. the Democrats. 5: A contraction of "procuracy", it's a person you authorize to vote in your place. proxy. Thanks for listening! Come back tomorrow for more exciting trivia! Special thanks to https://blog.feedspot.com/trivia_podcasts/

*RSR's List of Real Things, (That Are Real): Beginning with “Male and Female” RSR has designated “sex” as the first real thing to be listed on the RSR “List of Real Things”. These are real things that require no further debate regarding their fundamental definition. Do you have a nomination to add to RSR's many valuable lists? (FYI - the sum of 2+2 has already been nominated). Send your “real thing” to bob@rsr.org.  Laughing all the Way to Eternity: Listen in to clip from a classic episode of Real Science Radio with Michael Behe and hear Bob describe the sophistication of the “simple” Plant Hopper, with a joy that only Bob could put across on the radio.  *The Chicken and the Egg: An understanding of the process by which ATP synthase produces energy only leads one to the question of where did the energy come from to build the first ATP synthase? Here's a likely explanation.  Baby's Breath: Find out why so many religious traditions imply that a human being acquires “personhood”, (and the Right to Life) with their first breath, and how a more scientific analysis of Genesis 2:7 shows us respiration is about far more than just breathing.  *It's the Chicken All the Way: Our discussion was animated by the question of how much ATP is required to build the ATP Synthase, and that led to an examination of biblical versus secular attempts to explain the motor, imitate the motor, and to speculate as to how it could have come to be.  *Science in the Shadow of the Madmen: Find out how three Jews, (Fritz Lipmann, Hermann Kalckar & Hans Krebs fled the darkness of Hitler's Socialist Hellscape to lay the foundations of our understanding of molecular biology and how our bodies convert food into energy.  Anaerobic and Aerobic Exercise: Hear how the respiratory chain involves far more than simple breathing, and why this means a baby is a person before he can breathe.  Child's Play: Leave it to our Creator to make something like ATP Synthase - so irreducibly sophisticated that to understand it requires the greatest minds in science, and to mimic its simplest function requires institutional direction technological infrastructure, but the truth of it can be elucidated in one sentence by a child.

*RSR's List of Real Things, (That Are Real): Beginning with “Male and Female” RSR has designated “sex” as the first real thing to be listed on the RSR “List of Real Things”. These are real things that require no further debate regarding their fundamental definition. Do you have a nomination to add to RSR's many valuable lists? (FYI - the sum of 2+2 has already been nominated). Send your “real thing” to bob@rsr.org.  Laughing all the Way to Eternity: Listen in to clip from a classic episode of Real Science Radio with Michael Behe and hear Bob describe the sophistication of the “simple” Plant Hopper, with a joy that only Bob could put across on the radio.  *The Chicken and the Egg: An understanding of the process by which ATP synthase produces energy only leads one to the question of where did the energy come from to build the first ATP synthase? Here's a likely explanation.  Baby's Breath: Find out why so many religious traditions imply that a human being acquires “personhood”, (and the Right to Life) with their first breath, and how a more scientific analysis of Genesis 2:7 shows us respiration is about far more than just breathing.  *It's the Chicken All the Way: Our discussion was animated by the question of how much ATP is required to build the ATP Synthase, and that led to an examination of biblical versus secular attempts to explain the motor, imitate the motor, and to speculate as to how it could have come to be.  *Science in the Shadow of the Madmen: Find out how three Jews, (Fritz Lipmann, Hermann Kalckar & Hans Krebs fled the darkness of Hitler's Socialist Hellscape to lay the foundations of our understanding of molecular biology and how our bodies convert food into energy.  Anaerobic and Aerobic Exercise: Hear how the respiratory chain involves far more than simple breathing, and why this means a baby is a person before he can breathe.  Child's Play: Leave it to our Creator to make something like ATP Synthase - so irreducibly sophisticated that to understand it requires the greatest minds in science, and to mimic its simplest function requires institutional direction technological infrastructure, but the truth of it can be elucidated in one sentence by a child.

In part one of a two-part conversation, Drs. Patrick Loehrer and David Johnson sit down with Dr. Deborah Schrag to discuss her roles as a leader, researcher, oncologist and public health expert. The current Chair of the Department of Medicine at Memorial Sloan Kettering Cancer Center in New York, Dr. Schrag discusses the joy and passion she has found throughout her career, and more. If you liked this episode, please subscribe. Learn more at https://education.asco.org, or email us at education@asco.org.   TRANSCRIPT Dr. Pat Loehrer: I'm Pat Loehrer. I'm the Director of the Center of Global Oncology and Health Equity at Indiana University. Dr. David Johnson: Yes. And hello, I'm David Johnson. I'm at UT Southwestern in Dallas, Texas. Dr. Pat Loehrer: And welcome to another version of Oncology, Etc. Dr. David Johnson: Yeah, great guest today, before we get started with our guests, though, Pat, what are you reading these days? What can you recommend to me? Dr. Pat Loehrer: Well, I'm reading Jamie Raskin's book, which is about his son and about the insurrection. It's really a wonderful read so far, particularly I think about the family nature and how much he deeply respected his son who unfortunately committed suicide. Dr. David Johnson: Right before one of the impeachment trials as I recall, right? Dr. Pat Loehrer: It was right before the January 6 insurrection. Dr. David Johnson: Yeah, terrible situation. I have a book I've been meaning to recommend for a while. It's one that I've given to all the chief residents I've worked with over the last several years. And today's guests made me think about this book. It's entitled, Osler: Inspirations from a Great Physician. It's written by Charles Bryan, who's the former Chair of Medicine at the University of South Carolina in Columbia. Dr. Pat Loehrer: You trained with Osler, didn't you? Dr. David Johnson: I was a couple of years behind him. He was my senior resident. For anyone who's an Oslerphile, it's a great book to have. But even if you're not, it's got some wonderful lessons to be learned about how to interact with one's colleagues, and a lot of information about leadership, which is why it made me think of today's guest, Dr. Deborah Schrag who we're really excited to welcome to Oncology, Etc. Dr. Schrag is the Chairman of the Department of Medicine at Memorial Sloan Kettering Cancer Center in New York. She's a highly accomplished healthcare leader, clinician-researcher, and expert in public health and population science. Deborah received her medical degree from Columbia University and completed her residency in internal medicine at Brigham and Women's. She obtained her medical oncology training at Dana-Farber in Boston and also received an MPH degree from the Harvard School of Public Health. After a brief stint on the faculty at DFCI and Brigham and Women's, she joined the division of gastrointestinal Oncology at Memorial Sloan Kettering, where she was an associate member and Associate Professor of Public Health and Medicine. In 2007, I believe it was, she returned to Dana-Farber and Brigham, where she continued her work focused on improving the delivery, quality, and effectiveness of cancer care. While there, she served as chief of the Division of Population Sciences until this past year when she returned to Memorial to chair the Department of Medicine. I also think she's the first woman to hold this position, but we'll learn about that momentarily. Deb is internationally recognized as a pioneer for her work engaging patients in reporting outcomes as a way to improve care. She has led pragmatic trials using informatics strategies to optimize patient and clinician wellbeing, efficiency and quality, and equity of care. In short, she's a true superstar, leading the department, the major department, in one of the world's foremost Cancer Institutes. Deb, welcome to Oncology, Etc. Thank you so much for accepting our invitation. This is a relatively new oncology podcast, but already, we're known for our incisive, deeply penetrating questions. So, I have a question for you to start off. Do you have any carpentry skills? Dr. Deborah Schrag: Absolutely none whatsoever, Dave. None. Dr. David Johnson: I'm disappointed. It's my understanding that Schrag is German for cross or a slant and people who build cross-legged tables. So, I was hoping, my house was destroyed recently, and I'm looking for replacement furniture, and I was hoping you might be able to help me. Dr. Deborah Schrag: I apologize. But I'm not going to be able to help. The name, you're correct, though, David, is a German name. So, my family does hail from Germany and they made malt, which is the major ingredient in beer. I'm not sure where the name comes from. But they ran malt factories and shipped malt all over to all the beer, before there were craft beer distilleries, that's what they did. Dr. Pat Loehrer: That may come in handy by the end of this podcast, by the way. Dr. Deborah Schrag: Could be. Dr. David Johnson: Well, speaking of your family, tell us a little bit about your background and where you were raised, and your family members. Dr. Deborah Schrag: Sure! I'm glad you asked that because I really have been very influenced by where I grew up. And as I think about it, experiences that go back to first grade got me where I am today. So, I am from New York City. I grew up in Manhattan in the 1970s. And as you may know, that was a pretty rough time in the history of New York, what's often referred to as the 'bad old days', although it didn't feel that way to me. But I started out attending New York City public schools. And at that time in my neighborhood on the Upper West Side of Manhattan, my first-grade class had about 45 students, and one teacher, there were about five or six of us who spoke English, and everyone else was a recent Puerto Rican immigrant. I pretty much sat in the corner and read to myself. Now I didn't stay in the public school system for long, but I saw in first grade, how things weren't fair. And I saw and felt my own privilege, acutely. And even as a little kid, I had that sense. Eventually, my parents transferred me to private school later on. And there were kids in the neighborhood who didn't have the same privileges that I did. But living in New York, you walk around, you're confronted with disparities every day. We still see it today with homelessness on the streets. At that time, there was a lot of alcoholism and the use of drugs. And they were two blocks north that were safe to walk and two blocks east that were not safe to walk. So, this really stuck with me from a very early age. As a student in summer jobs, I worked lots of interesting jobs. I started at 14 scooping ice cream at Baskin Robbins, I worked at a famous Deli in New York called Zabar's, selling coffee. Lots of interesting jobs that I worked during holidays and vacation times. But one of my first jobs was working in an organization called the Floating Hospital, which was a big old ferry boat that circumnavigated Manhattan, and it provided a summer camp. And we would take 1800 people on a boat around Manhattan every day. And my job was to do lead testing. And I learned how to stick kids, test them for lead because there were incredible amounts of lead poisoning in New York City in the early 1980s. And then we would work on tracing the kids and these were toddlers, two-year-old, three years old. There were many families who were living in homeless shelters in New York City in the early 1980s. And that was really the beginning of my interest in public health and inequities. And really the marriage of medicine and public health. That had a deep and long-lasting impression on me and really stayed with me throughout my career. That early experience, I think it propelled me into medicine and to medical school and also to marry medicine and public health. Dr. Pat Loehrer: Tell me a little bit, Deb, about your parents. Dr. Deborah Schrag: Sure! My mother was born in the United States. She was a teacher who many years later after having three children went to law school and she became a litigator. And actually, her boss was Rudolph Giuliani. My father is a child of World War II. He was a child of German Jewish parents who had to flee the Nazis. Probably the most interesting story is that my paternal grandfather was an OB-GYN. So, I am a fifth-generation physician. My paternal grandfather was an OB-GYN at Charité, which is a very famous Hospital in Berlin. He was the head of OB-GYN there in the 1930s. But he had, I think he was half Jewish, and the Gestapo asked him to leave and he had to leave. He was an expert in version, which is essentially flipping babies and the setting of placenta previa. He then left for Lebanon, where he was in the French Resistance and had a thriving OB-GYN practice in Beirut, Lebanon, during World War II. And at night, there was a curfew, and he was part of the resistance and passed secrets around from the Russians to the French, so very dramatic. My father was born in this setting, and arrived as a new immigrant to the United States in the 1940s, where it was very hard to be a child whose parents had a German accent, given the prejudice against Germans at that time, but also went to New York City public schools, had a tremendous opportunity. It's really kind of the classic New York immigrant success story. You know, arrived in the United States with the shirts on their back and managed to work their way to a better life and achieve success and good education through public education for all their offspring. I will also say that my father had a public health stint. He worked in North Carolina as an alternative to going and serving in the Vietnam War, he was in the Public Health Service. And he worked in North Carolina in the textile mills and worked on a disease called byssinosis, which is also known as the brown lung. It's an occupational health disease that affects textile mill workers. As a child, I spent many dinners, hearing about byssinosis and brown lung, and black lung. I think at an early age I really came to understand how the world wasn't fair, and how it was instilled in me early on that it was important to work to try to make things better, particularly for people who didn't have privilege. And I think when you come from an immigrant family, and you realize how much privilege has been bestowed on you, that really leaves an indelible mark. I have to say, as Chair of Medicine at MSK, it is staggering to me the proportion of faculty here at MSK, but also at Dana-Farber, where I worked previously, we have lots and lots of immigrants who've been able to accomplish just amazing things through just motivation and drive and energy and creativity. And so, I'm a big believer in how much immigrants have powered this country. Dr. Pat Loehrer: Deborah, are your parents still alive? Dr. Deborah Schrag: My parents are still alive. They're both in their early 80s. And they both still live on the Upper West Side of Manhattan. So, I'm very privileged and fortunate to have living parents. Dr. Pat Loehrer: I can imagine the pride that they have for you. Dr. David Johnson: I just want to jump in and let our listeners know that Deb mentioned Charité in Berlin. That's the home of multiple Nobel laureates that all of us would know like Ernst Chain, who was one of the individuals involved in the development of penicillin, but Paul Ehrlich, Robert Koch, Hans Krebs, and for cancer doctors, Otto Warburg, among others. So, it truly is a world-renowned institution. Dr. Deborah Schrag: Well, my paternal grandfather was famous for this technique called version, which essentially involves putting your stethoscope next to the uterus, figuring out where the placenta was, and then essentially trying to flip the baby without disrupting the placenta or causing any harm, which required incredible skills with a stethoscope because you had to appreciate, I guess, the placental vessels. I'm not aware that this skill is still in existence, it was an important skill to have in the 1930s. When, if you did a C-section, there was a high probability of endometritis. So, you could save the baby, but you would often lose mom to endometritis. Or you could save mom, but you might not save the baby. So, at that time it was a big deal, but thankfully no longer. Dr. David Johnson: This is why we call it an Oncology, Etc. Our listeners didn't know that we're gonna get OB information in this particular podcast. Dr. Deborah Schrag: Or a digression on the history of medicine. I do find that, you know, I am inspired by the generations that came before me. I think it's also true that there are many physicians who are first-generation physicians in their families and some of us are privileged to have lots of healthcare professionals and sort of feel it as a calling. Dr. David Johnson: I think of you with many, many talents. But one of the things that I think stood out to me is, many years ago, you were in the van, talking about the financial cost of health care. I remember a very influential paper you wrote in the New England Journal, talking about the cost of treating GI cancer, colon cancer in particular. But where did your interest in that particular aspect of health care begin? What was the stimulus there? I mean, obviously you had a lot of stimulus from your family. What else? Dr. Deborah Schrag: That's really interesting. This is a little bit of a history of oncology. At that time, I was an assistant professor and assistant attending in the GI oncology service, seeing lots of patients with colorectal cancer. And we were working on a clinical trial of a drug called ImClone C225. And that was the name of the protocol. And we were putting patients in that clinical trial. And you know what? This drug was working. We were getting excited and the drug was moving ahead. We looked at the Phase 1 data and we launched Phase 2. We had meetings with the research protocol nurse and the research assistants, team meetings, and I would say there were about 50 people who were aware between the GI oncologists and the nurses and all the research assistants. You guys know that it takes a village and even though the villages were smaller then and it wasn't a particularly large trial, there are many, many people involved and everyone had the sense that this drug might be working. Just for context for our younger listeners, this is back in the early aughts, and basically, the drug that we had to treat colorectal cancer was 5-FU in many different formats and Irinotecan. And that was it. Some people thought mitomycin might work a little bit, but it was so horrible that it really barely worked. But that was what we had in our bag of tricks. So, the fact that we had this ImClone drug that eventually came to be known as Cetuximab, was remarkable. So, here's what happened. It turned out that this is the drug made by the company ImClone. And there were some shenanigans, some insider trading. And one of the people caught up in insider trading, in addition to some people involved with the company itself was none other than Martha Stewart, sort of the famous homemaker who still publishes magazines to this day. And you may know that she actually did some time in federal prison as a result of insider trading on this drug. I remember being a junior attending, and all the people involved in the trial and all the cancer professionals, we all knew this was working. But everyone respected the confidentiality of the situation, of the patients, and all the integrity that goes into academic medicine. And I remain inspired by the integrity of all the professionals, the doctors, the residents. These were not affluent people. I can tell you. we were not paying research assistants a whole hunk of money. They investigated every trade made by this company. There were absolutely no shenanigans or improprieties from the hard-working folks who helped bring this drug to market. So, as this was going on, we had many patients who were not eligible for the trial who were interested in getting the trial. So, of course, we followed as this drug got FDA approved and came to market. You could check me but I believe it was February 2004, it was FDA approved. It came out with a huge price tag. It was approximately $10,000 per month. I was mad because I was taking care of regular New Yorkers at that point. I had public school teachers, I had patients on Medicare and they couldn't afford the 20% copay. Because $10,000 a month for Cetuximab, if you have a 20% copay and you're New York City, public school cafeteria worker, is not yet eligible for Medicare with a typical plan that a New York City public school system employee would have, that was $2,000 a month. And that did not work for one of my patients who is essentially what we used to call a lunch lady. I was so mad that I decided to channel that anger into writing what I think is a perspective for the New England Journal called, “The Price Tag on Progress”. I wrote that piece. I know that many, many people and many of my esteemed colleagues have continued to work in that area and do research on the economics of drug pricing and there are many, many experts. I didn't stick with that. Not that it's not interesting, and not that it's not important. It's incredibly interesting and important, but I felt that the solution needed to happen in the legislature, state legislature, federal legislature. I think that this is about social policies, and we need to advocate for appropriate health insurance programs to make it possible for people to get coverage when they have catastrophic illnesses, and we need to think about the entire approach to drug pricing in this country. I still think that's important. I'm not convinced that what we need is more research on the topic. I think we need more policymaking and laws on the topic. I think we're still dealing with this. I'm sad to say that it's been nearly 20 years since I wrote that perspective. But I think it was motivated by frustration, not being able to get my patient what she needed, and many patients thereafter. And just the incongruity between some people benefiting from insider trading and all the good people who were doing the right thing. Dr. Pat Loehrer: I just want to throw in one thing if I can. Len Saltz, who's one of your partners, it was a piece of that trial that he presented at ASCO talking about ImClone C225. And ironically, it had a 22.5% response rate. And Len said, it's a bummer that ImClone didn't call it C995. Dr. Deborah Schrag: You have no idea how often we used to talk about that, joke about that in the clinic. I have another good story about that drug, which I think really illustrates something I believe and I think it's actually something that Osler said but it's also something I have to say I learned from both of you. And it has to do with listening to your patient. So, I had a patient named Matthew, who was a young man, 34 years old. He walked into my clinic with a diagnosis of diffuse metastatic colorectal cancer with multiple bilateral pulmonary metastases, which came to light when his tennis game was off. He was, at that time, an early employee of a newly started company called Google. And he was working on advertising algorithms, and Matt got the drug Cetuximab. And unfortunately, he was on it for quite some time. He was on it for about five or six months. But eventually, it was pretty clear that we were coming to the end of the road. And he and his wife planned a vacation. This was part of his end-of-life process planning. It was their fifth wedding anniversary in the Berkshires. We worked so hard to get Matt to the Berkshires to a beautiful inn, and on Saturday night, my pager goes off, and Matt cannot sit up. He's weak. And he'd been complaining of terrible fatigue for weeks, to me, and I really hadn't quite figured out why Matt was so fatigued. I mean, I just didn't understand it. And we get into this inn and I get a call from the Berkshire Medical Center, a small community hospital, 'Dr. Schrag, your patient is here. He's so weak and he can't sit up.' 'What's going on?' The ER doctor says, 'Well, he has a Chvostek sign', which is a sign of severe hypocalcemia. 'So, call me back with the calcium.' The calcium is low. Well, I think those of your listeners who are closer to medical school know that when the calcium is low, you have to check the mag. And Matt's magnesium was 0.2. And he got some magnesium in the Berkshire Medical Center. And all of a sudden, he felt great. He was able to go on and enjoy the second half of his fifth anniversary weekend at the Berkshire Inn and he came back. And I felt terrible because he'd been complaining to me of fatigue for six weeks and I hadn't checked his magnesium. I was like, 50 bilateral pulmonary metastases on chemotherapy. That's a fatigue explanation. Suffice it to say that we went on to start checking magnesium on everyone getting Cetuximab. Now mind you, the drug is FDA approved and FDA labeled at this point. So, we started checking magnesium, and we find that it was low. I start getting on the phone and calling my mentors. I called Dr. Bob Mayer, who was the head of my fellowship director and was like a revered mentor to me. 'Hey, Bob, does anyone up there in Boston have low magnesium from Cetuximab?' 'We don't check magnesium.' I said, 'But can you check?' I started calling around and that's a great example of the community of oncology. We are a community. I just started working the phones and calling friends and saying 'You guys checking magnesium for any of these folks on Cetuximab?' Suffice it to say, we figured out that their EGFR receptors in the ascending loop of Henle - so, again, back to biology and pathophysiology - the drug Cetuximab was blocking reabsorption of magnesium in the kidney, and it was Cetuximab that caused a terrible magnesium wasting. Oral magnesium did not work. You had to give it intravenously, repeatedly. And we helped eliminate fatigue for a bunch of patients. About six months later, I showed up at ASCO with these little cardboard slides and a little poster back in the corner and put up our little case series, very little. But I'm proud to say that we changed the label of Cetuximab and it's now on the label that it causes hypomagnesemia. It might be one of my more cited papers, paradoxically. But I think it's a principle that really has stuck with me, and I've tried to impart it to all the students and residents and fellows, 'Listen to your patients because - I think it comes from Osler- they're telling you something. We have to pay attention.' Again, I have never forgotten that. But really listening and trying to figure out how we can use our understanding of pathophysiology and what our patients tell us to ask questions and not just accept dogma and try to figure out what we can do. And you know, I couldn't have figured that out on my own. I happened to find a really smart nephrologist who happened to be able to sort of go to animal models and knew the right studies and the right people to talk to. Dr. David Johnson: It's one of the reasons why we are a multidisciplinary specialty. And we use the expertise of our colleagues. I think that's such a wonderful example of listening to one's patient and it really profoundly impacted our understanding of how that drug works and renal physiology, actually. That wraps up part one of our interview with Dr. Deborah Schrag, Chair of Medicine at Memorial Sloan Kettering Cancer Center. We hope you've enjoyed learning about her background and her early career. In part two of our conversation, Dr. Schrag will discuss her programmatic goals at Memorial Sloan Kettering, the importance of mentorship and leadership, and what it means to have joy in the profession of medicine, and, frankly, much more. So, please be sure to join us. As always, we want to thank you for tuning in to Oncology, Etc. an ASCO educational podcast, where we will talk about just about anything and everything. So, if you have an idea for our topic or a guest, please email us at education@asco.org. Unknown Speaker: Thank you for listening to the ASCO Education Podcast. To stay up to date with the latest episodes, please click subscribe. Let us know what you think by leaving a review. For more information, visit the comprehensive education center at education.asco.org.   The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity or therapy should not be construed as an ASCO endorsement.

Derek Hockaday interviews George Alberti, research endocrinologist and former President of the Royal College of Physicians, 24 May 2013. Topics discussed include: (00:00:00) admission into Balliol to study medicine, preliminaries and early years in Oxford, Sandy Oxton (00:05:15) Coolidge Scholarship to go to United States; (00:07:50) Biochemistry and DPhil project at Hans Krebs lab on amino acid metabolism in mitochondria; (00:12:12) work ethic and start of clinical work, involvement in teaching tutorials; (00:16:37) Endocrinology and diabetes research; (00:20:00) finals; (00:21:33) teaching staff; (00:25:23) visits to United States, post-qualification fellowship applications; (00:27:35) research and clinics in Boston; (00:31:57) returning to Oxford to do clinical research; (00:35:40) comparing the Radcliffe and Oxford in general to other places clinically (United States, Southampton, Brighton); (00:36:43) Oxford undergraduate course as preparation for a career in medicine; (00:38:07) clinical research at the Hans Krebs unit; (00:42:10) reasons for leaving Oxford; (00:44:50) influence of multiple analyser on clinical biochemistry; (00:46:27) progression of the medical school since leaving Oxford; (00:48:25) reflection on teaching pre-clinical tutorials. Note that the following sections of audio are redacted: 00:09:29-00:09:35; 00:15:56-00:16:18; 00:23:40-00:23:42; 00:49:33-00:49:38.

Georgina Ferry interviews Eric Sidebottom. Eric Sidebottom has been associated with the Dunn School for more than 50 years, as medical student, lecturer, and recently, official historian. Sidebottom came to Oxford to read medicine at a time when two Nobel prizewinners, Howard Florey and Hans Krebs, were still lecturing to undergraduates. He completed his medical training at St Bartholomew’s Hospital in London and came to the Dunn School as one of Henry Harris’s first DPhil students in 1966. Sidebottom became interested in cancer, and used Harris's cell fusion technique to explore the ability of cancer cells to spread throughout the body, or metastasise. Following the death of John French, Harris appointed him to organise all the teaching in the department, which led him to administrative roles including chairing the board of the Faculty of Medicine. In the late 1980s Sidebottom moved to the Imperial Cancer Research Fund as Assistant Director of Clinical Research. Returning to the Dunn School after five years, he has since focused on the history of Oxford medicine, publishing Oxford Medicine: A Walk Through Nine Centuries, and Penicillin and the Legacy of Norman Heatley (with David Cranston).

This episode brought to you by Rock Lobster Cycles, beautiful bicycles handbuilt in Santa Cruz, California. In our last interview, scientist and world champion rower Dr Brianna Stubbs had recently successfully defended her PhD in Biochemical Physiology and reached a juncture in her career. Ten months later, Brianna has retired from professional rowing but continues her passion for biochemistry with San Francisco based nootropics company HMVN where she is working to commercialise the D-BHB ketone monoester developed at Oxford University alongside Prof. Kieran Clarke. The big news is the wait is over! After over a decade of research, the ester is finally here. This interview is two rolled into one. In the first part, we talk about Brianna’s transition out of academia and professional sport and into the world of Silicon Valley startups. In the second part, Brianna talks about the benefits of the ketone ester and takes on some of Dr Tommy Wood’s challenging questions given to me by ahead of the interview but unseen by Brianna. If you’re only interested in hearing about the ketone monoester, skip to the 24-minute mark. Here’s the outline of this interview with Brianna Stubbs, PhD: [00:01:23] Retirement from rowing. [00:02:56] Podcast: Off Road Triathlon World Champion Lesley Paterson on FMT and Solving Mental Conundrums. [00:03:19] App: Strava. [00:04:17] The move to San Francisco. [00:05:00] Professor Kieran Clarke, PhD, CEO of TdeltaS. [00:05:24] HVMN. [00:08:27] World Rowing Championships. [00:09:40] Rodent and then human experiments. [00:10:37] Finding purpose and resolving ambivalence. [00:12:09] Journaling. [00:12:55] Mentoring. [00:14:42] Podcast: How to Create Behaviour Change with Simon Marshall. [00:15:08] YouTube: HVMN Enhancement Podcast: Ep. 46: Correcting Nutritional Deficiencies ft. Christopher Kelly. [00:15:38] Tony Hsieh of Zappos.com. [00:16:38] Body composition. [00:17:39] BHRT (Bioidentical Hormone Replacement Therapy). Podcast: The Critical Role of Oestradiol for Women’s Cognition with Dr. Ann Hathaway, MD. [00:17:57] DXA scan. [00:18:09] Intermittent fasting. [00:19:22] We Fast Facebook Community. [00:20:42] Put on 20lb, mostly muscle. [00:24:51] Podcast: World Champion Rower and Ketone Monoester Researcher Brianna Stubbs. [00:25:19] Dr. Richard Veech, Hans Krebs. [00:26:52] Ketone metabolism. [00:28:04] Study: Cox, Pete J., et al. "Nutritional ketosis alters fuel preference and thereby endurance performance in athletes." Cell metabolism 24.2 (2016): 256-268. [00:28:47] Case Report: Newport, Mary T., et al. "A new way to produce hyperketonemia: use of ketone ester in a case of Alzheimer's disease." Alzheimer's & Dementia 11.1 (2015): 99-103. [00:29:20] FDA GRAS (generally recognized as safe). [00:29:32] WADA. [00:30:38] Who is the ester for? [00:31:54] Article and Studies: Reference 1, 2 and 3. [00:33:30] Glycogen sparing or impairing? [00:35:57] WINGATE test. [00:36:08] If you've got ketones, you don't break down as much protein? BCAA. [00:36:32] Study: Vandoorne, Tijs, et al. "Intake of a Ketone Ester Drink during Recovery from Exercise Promotes mTORC1 Signaling but Not Glycogen Resynthesis in Human Muscle." Frontiers in physiology 8 (2017). [00:37:27] Pro cycling. [00:39:00] Study: Youm, Yun-Hee, et al. "The ketone metabolite [beta]-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease." Nature medicine 21.3 (2015): 263-269. [00:40:05] Why is glucose required for an increase in exercise performance? [00:41:12] Anaplaerosis. See Tommy’s letter published recently in the journal Strength and Conditioning. [00:42:19] Should we stop using the salts? [00:42:41] Appetite suppressing effects of ketones. [00:43:02] D and L isomers. [00:44:11] Dominic D'Agostino, PhD. [00:45:14] Are diet and lifestyle still the most important factors? [00:46:36] Caffeine, nitrates, beta-alanine. [00:47:31] Ketone ester 30 min rowing performance. [00:49:21] Podcast: SNR #195: Brendan Egan, PhD – Exogenous Ketone Supplementation. [00:52:25] Study: Volek, Jeff S., et al. "Metabolic characteristics of keto-adapted ultra-endurance runners." Metabolism 65.3 (2016): 100-110. [00:52:41] Intramuscular triglycerides. [00:53:07] Ketones as signaling molecule. [00:53:46] YouTube: HDAC inhibitors and Podcast: A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice with Megan Hall. [00:54:27] Nicotinic acid receptor. [00:55:11] Book: Behave: The Biology of Humans at Our Best and Worst by Robert M. Sapolsky. [00:56:16] General anesthesia. [00:57:11] Two papers, Kieran hyperglycemia and Veech (ask Tommy) [00:59:02] Exogenous ketones lower blood glucose. [00:59:46] Biden pancreatic islet study [01:00:26] Insulin is anti-proteolytic. [01:00:37] George Cahill paper [01:03:03] Who's it for? [01:03:12] Price. [01:04:06] Intestinal Alk Phos. See Why You Should Skip Oxaloacetate Supplementation, Fueling for Your Activity and More with Dr. Tommy Wood. [01:06:12] Product page at HVMN.

A daily devotional through the recorded words Jesus spoke while He walked alongside us. Our website http://alittlewalkwithgod.com. Thanks for joining me today for "A Little Walk with God." I'm your host Richard Agee. When I was in school, the Krebs Cycle was a lot more theory than fact. Things have changed over the years in science, but not in God's word. So what does the Krebs Cycle have to do with God's word? Stay and find out. Scripture John 7:16-19 Jesus: I do not claim ownership of My words; they are a gift from the One who sent Me. If anyone is willing to act according to His purposes and is open to hearing truth, he will know the source of My teaching. Does it come from God or from Me? If a man speaks his own words, constantly quoting himself, he is after adulation. But I chase only after glory for the One who sent Me. My intention is authentic and true. You'll find no wrong motives in Me. Moses gave you the law, didn't he? Then how can you blatantly ignore the law and look for an opportunity to murder Me?   Devotional When I took biology in Vanderbilt more than 40 years ago, scientists were just beginning to uncover the secrets of how cells transformed matter into energy to run the various processes of the body. They knew there was this thing called the mitochondrion that took in oxygen and released carbon dioxide and energy enriched adenosine triphosphate but didn't understand how. My professor at the time had worked with Hans Krebs and would win his own Nobel Prize in Physiology Now, the mechanism has been changed from a theory to a fairly well accepted biochemical process fact among biologists worldwide. Many theories proposed previously All missed some important part in their explanation Brilliant people, but holes in their argument Krebs cycle explained the process and verified by improved electron microscopes Why did the theory become accepted as fact when all the others failed Questions were answered Things fit into place Theory proven by independent sources Has stood the test of time for over 50 years now Curious that we will accept Krebs Cycle as truth which we've only recognized for 50 years but don't recognize God's truth which has been here since time began Stories handed down since God created Adam and Eve Moses given the law on Mt Sinai and scholars believe gave the Israelites the five books of the law, Genesis through Deuteronomy Centuries of testimony from Israelites and Christian community Evidence all around us Still we won't believe the truth We won't listen to those sharing God's word, but instead listen to those who tell us what we want to hear Time to be convicted by God's law. Time to hear what He has to say instead of what the world has to say. Time to let the truth guide our lives instead of the lies Satan lays before us. Time to follow the Son, the One God says is the only way to salvation, freedom, and life If you want to learn more about my church, you can find us at SAF.church. If you like the devotional, share it with someone. If you don't, tell me. I hope you'll join me again tomorrow for "A Little Walk with God."  

A rap about Hans Krebs and the Krebs Cycle written and performed by Oort Kuiper.

Professor Simon Foster, Lead Academic for Krebs Fest gives a quick background to Sir Hans Krebs, and describes his importance to Sheffield.

Dave Hornby, Professor of Biochemistry at the University of Sheffield delves into the history of Sir Hans Krebs, and describes his journey to Sheffield via Germany and Cambridge. Filmed during a public talk at Krebs Fest.

Gott will dir ewiges Leben schenken. Heute hört ihr die Geschichte von einem jungen Sportler – dem erfolgreichen Läufer Hans Krebs! Diese Geschichte hat sich tatsächlich so zugetragen. Als er eines Tages mit einigen Kumpels duch den Wald joggt, macht er eine längere Pause als geplant … 1. Korinther 9 Vers 24

Ist dir dein Hobby / Sport zu wichtig? Heute hört ihr die Geschichte von einem jungen Sportler – dem erfolgreichen Läufer Hans Krebs! Diese Geschichte hat sich tatsächlich so zugetragen. 1. Korinther 9 Vers 24

Ist dir dein Hobby / Sport zu wichtig? Heute hört ihr die Geschichte von einem jungen Sportler – dem erfolgreichen Läufer Hans Krebs! Diese Geschichte hat sich tatsächlich so zugetragen. 1. Korinther 9 Vers 24

Ist dir dein Hobby / Sport zu wichtig? Heute hört ihr die Geschichte von einem jungen Sportler – dem erfolgreichen Läufer Hans Krebs! Diese Geschichte hat sich tatsächlich so zugetragen. 1. Korinther 9 Vers 24