POPULARITY
Categories
(0:00) Miami QB Carson Beck (10:30) Penn State QB Drew Allar (21:30) Washington WR Denzel Boston (31:30) Texas A&M WR KC ConcepcionSee omnystudio.com/listener for privacy information.
(0:00) LSU QB Garrett Nussmeier (8:00) USC WR Makai Lemon (15:30) Arizona State WR Jordyn Tyson (23:30) Alabama QB Ty Simpson (32:00) Ohio State WR Carnell Tate (38:40) Indiana QB Fernando MendozaSee omnystudio.com/listener for privacy information.
(0:00) Steelers’ communication change proposal during negotiation period (15:00) NFLPA report card survey leaked (30:00) Colts give Anthony Richardson permission to seek a trade (46:30) Connor Rogers joins the show to talk impressive combine workoutsSee omnystudio.com/listener for privacy information.
(0:00) Ravens GM Eric DeCosta “definitely” confident on reaching extension with Lamar Jackson (5:00) Ravens HC Jesse Minter on getting Lamar Jackson to attend OTAs (20:00) Broncos HC Sean Payton will give up play-calling duties to OC Davis Webb (29:00) NBC Sports’ Joshua Perry joins the show (38:00) Patriots HC Mike Vrabel from yesterday (54:00) Raiders’ asking price for Maxx Crosby (57:30) Who should pursue Crosby?See omnystudio.com/listener for privacy information.
(0:00) Revisiting yesterday's interviews (10:00) Will Tua Tagovailoa be in Miami next season? (28:00) Kyler Murray and Cardinals destined to part ways (41:00) Vikings “going to explore every opportunity” with QB situationSee omnystudio.com/listener for privacy information.
(0:00) Texas TE Jack Endries (8:45) Ohio State TE Max KlareSee omnystudio.com/listener for privacy information.
(0:00) Ohio State S Caleb Downs (9:30) Toledo S Emannuel McNeil-Warren (19:30) Texas S Michael Taaffe (28:00) Oregon S Dillon ThienemanSee omnystudio.com/listener for privacy information.
(0:00) Texas CB Malik Muhammad (8:15) Miami CB Keionte Scott (15:00) LSU CB Mansoor Delane (24:00) Clemson CB Avieon Terrell (28:30) Tennessee CB Jermod McCoySee omnystudio.com/listener for privacy information.
Mike Florio of PFT and NBC joins Dick Fain to discuss what concerns Seahawks fans should have right now, running back contracts and the new money for Javonte Williams, Trent Williams with the 49ers, Malik Willis and free agency, plus Lamar Jackson’s future.See omnystudio.com/listener for privacy information.
(0:00) Mike Vrabel (16:30) Todd Monken (32:30) Mike MacdonaldSee omnystudio.com/listener for privacy information.
(0:00) Auburn ED Keldric Faulk (11:00) Texas Tech ED David Bailey (18:30) Texas A&M ED Cashius HowellSee omnystudio.com/listener for privacy information.
(0:00) Ohio State DL Kayden McDonald (15:00) Clemson DL Peter Woods (23:00) Florida DL Caleb BanksSee omnystudio.com/listener for privacy information.
(0:00) Recapping interviews from yesterday (16:00) NFL admits to bad calls in Week 14 Steelers-Ravens game (27:00) Will Eagles trade A.J. Brown? (36:00) Jon Spytek expects Maxx Crosby to remain a Raider (44:30) Nick Caserio responds to C.J. Stroud trade rumors (53:30) Andrew Berry on Browns starting QBSee omnystudio.com/listener for privacy information.
(0:00) Texas LB Anthony Hill (10:00) 49ers struggling on a new deal with Trent Williams (15:00) Georgia LB CJ Allen (22:30) Ohio State LB Sonny Styles (32:30) Ohio State LB Arvell Reese (41:00) Upcoming combine interviewsSee omnystudio.com/listener for privacy information.
(0:00) Falcons will place franchise tag on Kyle Pitts Sr. (10:00) PFT’s top free agents (18:00) NFL to consider allowing replay officials to flag non-football acts (27:00) Playoff reseeding plan will not be reintroduced until season expands to 18 games (31:30) Most memorable Scouting Combine moments (35:00) Lions to play in Munich next seasonSee omnystudio.com/listener for privacy information.
(0:00) Welcome to the Scouting Combine (5:00) Cowboys plan to franchise tag George Pickens (22:30) Stephen Jones on Pickens: “We want him here” (48:00) Colts and Daniel Jones begin negotiations on a multi-year extensionSee omnystudio.com/listener for privacy information.
Furf and Monty are back with another Pulm PEEPs Pearls episode. The topic of today’s discussion is an often discussed, but often misunderstood, test; the methacholine challenge. They’ll review when to utilize this test, how it should be performed, and the appropriate interpretation. Contributors This episode was prepared with research by Pulm PEEPs Associate Editor George Doumat. Dustin Latimer, another Pulm PEEPs Associate Editor, assisted with audio and video editing. Key Learning Points What the Test Measures Methacholine challenge is a direct bronchial provocation test of airway hyperresponsiveness (AHR), a core physiologic feature of asthma. Anyone will bronchoconstrict at high enough concentrations — the test looks for an abnormal threshold. The key endpoint is the PC20: the methacholine concentration causing a 20% fall in FEV1. Abnormal in adults: PC20 ≤ 8–16 mg/mL Test Performance Meta-analyses: pooled sensitivity ~60%, specificity ~90%. Real-world cohorts: sensitivity 55–62%, specificity 56–100% (varies by population, protocol, and threshold used). Not a standalone yes/no test — best used as part of a broader diagnostic pathway. Where It Fits in the Asthma Workup The test belongs in a stepwise approach: Step 1: Spirometry + bronchodilator response Step 2: Add FeNO and/or peak flow variability (if available) Step 3: If the picture is still unclear → methacholine challenge It is most useful for symptomatic patients with normal spirometry and no bronchodilator reversibility. Given its cost, mild risk, and discomfort, it should not be a first-line test — most asthma diagnoses do not require it. Technique and Medication Prep Technique ERS guidelines favor tidal breathing over deep inspiratory maneuvers. Deep breaths can be bronchoprotective and blunt the response, reducing sensitivity — especially in mild or well-controlled asthma. Medication Washout (to Avoid False Negatives) Medication ClassWashout PeriodShort-acting beta-agonists (SABA)≥ 6 hoursLong-acting beta-agonists (LABA)~24 hoursUltra-long-acting beta-agonists~48 hoursShort-acting anticholinergics (e.g., ipratropium)~12 hoursLong-acting muscarinic antagonists (LAMA, e.g., tiotropium)7 days Inhaled corticosteroids, leukotriene blockers, and antihistamines do not significantly affect the test acutely — continue these. Withdrawing ICS also carries its own risk for asthma patients. Practical tip: Spell out exactly what to hold and when — for both the patient and the PFT lab — at the time the test is ordered. Interpreting Results Negative Test (PC20 > 16 mg/mL) Very high negative predictive value in symptomatic adults. Makes current asthma quite unlikely (assuming proper test conduct). This is the test’s greatest strength: it is an excellent rule-out test. Positive Test (PC20 ≤ 8–16 mg/mL) More nuanced — airway hyperresponsiveness is not unique to asthma. Can be positive in: chronic cough, allergic rhinitis, COPD, and even some healthy asymptomatic individuals. A positive result raises probability but must be interpreted alongside the clinical story, variable respiratory symptoms, peak flow variability, FeNO, and ICS response. Safety and Risks Overall, the test is quite safe; significant adverse effects are rare. Temporary breathing discomfort is expected (bronchoconstriction is being induced). Severe bronchospasm is possible: A trained clinician should be available; SABA inhaler/nebulizer must be immediately on hand; a physician should be reachable in the facility. Contraindications / cautions: Avoid if FEV1 < 70% predicted or < 1–1.5 L (baseline obstruction greatly increases risk). Avoid within 3 months of an acute cardiac event (rare risk of cardiac events with unstable cardiac disease). Five Pearls — Quick Recap What it tests: Methacholine challenge is a direct test of AHR with high specificity but variable sensitivity — it belongs inside a diagnostic pathway, not as a standalone asthma test. When to use it: Most useful for symptomatic patients with normal spirometry and no bronchodilator response, after FeNO and peak flow variability have been considered. Technique and meds matter: Use tidal breathing protocol; respect washout intervals — especially the 7-day LAMA washout and 24–48 hour LABA window — to avoid false negatives. Safety: Generally safe, but can induce significant bronchoconstriction. Have a SABA available and avoid the test in patients with FEV1 < 70% predicted. Interpretation: A negative test (PC20 > 16 mg/mL) strongly argues against current asthma. A positive test raises probability but is not specific — interpret alongside the full clinical picture. References and Further Reading Coates AL, Wanger J, Cockcroft DW, Culver BH; Bronchoprovocation Testing Task Force: Kai-Håkon Carlsen; Diamant Z, Gauvreau G, Hall GL, Hallstrand TS, Horvath I, de Jongh FHC, Joos G, Kaminsky DA, Laube BL, Leuppi JD, Sterk PJ. ERS technical standard on bronchial challenge testing: general considerations and performance of methacholine challenge tests. Eur Respir J. 2017 May 1;49(5):1601526. doi: 10.1183/13993003.01526-2016. PMID: 28461290. Lee, J., & Song, J. U. (2021). Diagnostic comparison of methacholine and mannitol bronchial challenge tests for identifying bronchial hyperresponsiveness in asthma: a systematic review and meta-analysis. Journal of Asthma, 58(7), 883–891. https://doi.org/10.1080/02770903.2020.1739704 Davis BE, Blais CM, Cockcroft DW. Methacholine challenge testing: comparative pharmacology. J Asthma Allergy. 2018 May 14;11:89-99. doi: 10.2147/JAA.S160607. PMID: 29785128; PMCID: PMC5957064.
(0:00) USA Men’s and Women’s Hockey wins gold (20:00) NFL Combine preview (33:00) Could Ty Simpson be a first-round pick? (39:00) Jags HC Liam Coen & GM James Gladstone will not attend combineSee omnystudio.com/listener for privacy information.
(0:00) Remembering Rondale Moore (2000-2026) (22:00) Cowboys re-sign Javonte Williams (26:00) Seahawks reportedly will not franchise tag Kenneth Walker III (34:00) Will Breece Hall be a Jet for 2026? (37:00) JSN: “I believe I deserve to be the highest paid in my position” (45:00) No team has submitted a tush push ban to competition committee (48:30) Will Bears make a move to Indiana? (51:30) PFT combine previewSee omnystudio.com/listener for privacy information.
Mike Florio of PFT and NBC joins Dave Softy Mahler and Dick Fain to talk about the sale of the Seahawks becoming official today, the process and ownership dynamics of the situation, Kenneth Walker’s uncertain future, SF vs. LA in Australia, KC, and Miami.See omnystudio.com/listener for privacy information.
On today's episode the guys are back in the studio (including PFT!!) to get into all the news from the weekend. They discuss Obama discussing aliens, the NBA All Star game and the Winter Olympics, Anthony Kim and everything going on in the golf world, their favorite bodies of water, Michael Jordan and much more. Enjoy! (00:06:38) Obama Says Aliens Are Real (00:10:01) NBA All Star Game (00:12:22) Winter Olympics (00:21:40) Anthony Kim/Golf (00:40:55) Bodies of Water (00:45:20) AI (01:12:35) Michael Jordan (01:21:45) Teed Off (Valentine's Day Reservation) (01:23:28) Teed Off (Miami of Ohio)You can find every episode of this show on Apple Podcasts, Spotify or YouTube. Prime Members can listen ad-free on Amazon Music. For more, visit barstool.link/macrodosing
(0:00) Message from reader on mental health (9:30) Does the NFL have a tanking problem? (29:30) Klint Kubiak on Maxx Crosby (33:00) Should Raiders trade Crosby?See omnystudio.com/listener for privacy information.
(0:00) Terry McAuley assisted 2-pt conversion review in Week 16 LAR-SEA matchup (15:00) Seahawks begin preliminary process to sell team (22:00) Will NFL take action against Steve Tisch? (37:30) Bears won’t receive draft compensation for losing Ian Cunningham to Falcons (43:00) Dolphins moving closer to a decision on Tua Tagovailoa’s future See omnystudio.com/listener for privacy information.
Stay F. Homekins: with Janie Haddad Tompkins & Paul F. Tompkins
This is a free preview of a paid episode. To hear more, visit weekendwater.substack.comHey y'all!!So sorry we got behind a week, but get ready for this BONUS DOUBLE EP RECAP AND REACT POD!!We are starting to fully form our opinions on this season's cast. Guess what: underwhelming! And I have a dark energy theory on KIM. PFT has a dark energy theory on just…the entire gang. But does that stop us from having FUN discussing these past two ep…
(0:00) How big is the target on Patriots for 2026? (15:00) Mac Jones reinvigorated with 49ers, Kyle Shanahan (28:00) Joey Porter Sr. rips Ben Roethlisberger (45:00) James Pearce Jr. arrested after domestic dispute (48:00) $24 million bet on whether Mark Walhberg would attend Super Bowl (50:00) Giants co-owner Steve Tisch named in Epstein filesSee omnystudio.com/listener for privacy information.
(0:00) Ernest Jones IV sends a message to Seahawks’ doubters (12:00) George Kittle wants to know if electrical substation is a problem (20:45) Sam Darnold thanks his believers (28:00) Zach Charbonnet’s 2-pt conversion vs Rams (37:30) Seahawks to interview four in-house candidates for OC job (41:00) Key Seahawks free agentsSee omnystudio.com/listener for privacy information.
Mike Florio of PFT and NBC joins Dave Softy Mahler and Dick Fain to talk about Seattle blowing out New England in the Super Bowl, Sam Darnold’s performance and narrative shifting career, what comes next for the Seahawks now, and Kenneth Walker III’s future.See omnystudio.com/listener for privacy information.
(0:00) Raiders introduce Klint Kubiak to media (7:30) Kubiak on working with Tom Brady (13:30) Will Aaron Rodgers return in 2026? (22:00) Commanders OC David Blough to move Jayden Daniels under center (28:30) Seahawks will hold championship parade today (30:00) Issues with prediction marketsSee omnystudio.com/listener for privacy information.
(0:00) SB LX leftovers (22:00) SB LX viewership ratings (36:00) Chris' interaction with Bad Bunny on Sunday (41:00) Should NFL rethink forcing players to speak after losses? (46:00) Will Campbell on declining to speak to media following SB loss (1:01:00) Will Campbell responds to criticismSee omnystudio.com/listener for privacy information.
(0:00) Super Bowl LX recap (21:00) Drake Maye shoulder injury (30:00) Mike Macdonald on turning point for Seahawks (36:00) Macdonald on Sam Darnold (39:00) Leonard Williams & Julian Love on Seahawks defenseSee omnystudio.com/listener for privacy information.
(0:00) Potential Week 1 opponents for Seahawks (19:00) Drake Maye & Mike Vrabel reflect on Super Bowl LX loss (36:00) Mike Macdonald on Seahawks being “target No. 1” in 2026 (42:30) Way too early Super Bowl LXI odds (45:00) Raiders hire Klint Kubiak (49:00) Maxx Crosby reportedly told Tom Brady he’s done with Raiders (51:00) When will NFL move to 18-game regular season? See omnystudio.com/listener for privacy information.
On today's episode Big T, Arian and Tbob are joined by Zachary Foust, a Delaware Realtor, to discuss everything that is going on in the news. They get into the Epstein Files, Derek Dooley running for office, Marchsawn Lynch and Bill Mahar, the housing crisis, the economy and much more. Plus, PFT pops in to give us a PFT plane corner update. Enjoy! (00:03:15) Epstein File Updates (00:25:03) Derek Dooley (00:30:26) Marshawn Lynch (00:38:56) LSU Embezzlement Case (00:47:04) PFT's Plane Corner (00:51:10) Zachary FoustYou can find every episode of this show on Apple Podcasts, Spotify or YouTube. Prime Members can listen ad-free on Amazon Music. For more, visit barstool.link/macrodosing
In the first hour, Dave Softy Mahler and Dick Fain hear from Seahawks end Uchenna Nwosu on his feelings about getting after the Patriots, then talk to Mike Florio of NBC and PFT plus former Juanita and Seattle receiver Bryan Walters before Fun w/ Audio.See omnystudio.com/listener for privacy information.
Mike Florio of NBC and PFT sits down on radio row with Dave Softy Mahler and Dick Fain to talk about the Super Bowl setup in the Bay Area, the actual game on Sunday between the Seahawks and Patriots, plus all the reports surrounding the Hawks’ sale.See omnystudio.com/listener for privacy information.
Super Bowl Week Day 2 and the Hank vs PFT rivalry is heating up. We talk about the bullshit international games, Bob Kraft being snubbed and NBA trades (00:00:00-00:46:24). Hot Seat/Cool Throne including Lindsey Vonn and the Grammy's we didn't watch (00:46:24-01:07:55). Draymond Green joins the show for an awesome interview about his career, possibly being traded, playing Defense at an elite level, Steph Curry, Tom Izzo, ball kicks and tons more (01:07:55-02:42:28). Scott Zolak joins to talk Patriots, Super Bowl, stories of backing up Dan Marino and how he thinks the game is going to go (02:42:28-03:17:17). We finish with Guys on Hank (03:17:17-03:27:52).You can find every episode of this show on Apple Podcasts, Spotify or Netflix. Prime Members can listen ad-free on Amazon Music. For more, visit barstool.link/pardon-my-take
(0:00) Sam Darnold gifted ham hat (10:00) Robert Kraft not selected for HOF (19:00) Matt Simms joins the set (22:00) Giants hire Matt Nagy as OC (32:00) Matt Simms shares SB LI experience (42:00) Commissioner Goodell holds annual state of NFL press conferenceSee omnystudio.com/listener for privacy information.
(0:00) Chris “Mad Dog” Russo joins the show (17:00) Michael Holley talks Patriots (29:30) 10 coaches hired this cycle, no Black head coaches hired (35:00) Commissioner Goodell on Rooney Rule (40:30) Patrick Surtain II & Nik Bonitto join the showSee omnystudio.com/listener for privacy information.
In the third hour, Dave Softy Mahler and Dick Fain talk to NBC and PFT’s Chris Simms about working with Mike Florio and Super Bowl LX ahead, live on radio row, then Hawks legend Lofa Tatuput joins to discuss Sunday’s game, before Gregg Bell joins the show.See omnystudio.com/listener for privacy information.
Chris Simms of NBC and PFT joins Dave Softy Mahler and Dick Fain to talk about Mike Florio, the Seahawks and Patriots winding up in the Super Bowl, Sam Darnold’s groove going into Sunday, Seattle’s Dark Side defense, and how New England stops Seattle.See omnystudio.com/listener for privacy information.
(0:00) NBCSports Boston’s Tom Curran joins the show (22:00) Vikings fire GM Kwesi Adofo-Mensah (32:00) Super Bowl LX uniforms (36:00) Super Bowl trivia (38:00) Seahawks/Patriots odds from preseasonSee omnystudio.com/listener for privacy information.
(0:00) Welcome to Super Bowl LX (30:00) Seahawks owner Jody Allen putting team up for sale following SB (40:00) Raiders reach deal with Klint Kubiak as next HC (48:30) Cardinals hire Rams OC Mike LaFleur as HCSee omnystudio.com/listener for privacy information.
2:00 - Head Coaches in suits for their introductory press conferences6:45 - Get your copy of Big Shield for $.998:45 - Happy belated Birthday Kristen Coleman!11:00 -- PFT's schedule next week in San Francisco (Live on Peacock - 12Noon ET- 2PM ET)13:45 - Joe Brady introduced as Bills Head Coach; Brady on having high expectations18:15 - Joe Brady on Josh Allen22:20 - Josh Allen on broken bone in his foot25:30 - Josh Allen on disappointment of another playoff loss33:00 - Peter King joins the show37:20 - Florio and King on Bill Belichick 1st ballot Hall of Fame snub41:00 - Should there be an "upper room" to the Hall of Fame reserved for the best of the best who ever played? Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
On today's episode PFT, Big T and Arian are joined by Francis Ellis to discuss the legend of Davy Crockett. Davy Crockett was an American frontiersman, soldier, and politician known for his rugged frontier life and hunting skills. Born in Tennessee in 1786, he later served in Congress and opposed Andrew Jackson's Indian Removal Act. He died fighting for Texas independence at the Battle of the Alamo in 1836. Plus, the guys get into the Manning family, the new Cleveland Browns head coach, Patrick Reed rejoining the PGA Tour, the doomsday clock and much more. Enjoy! (00:02:27) Francis Joins the Show (00:18:37) NFL Quarterbacks & Actors (00:29:44) The Manning Family (00:32:09) Cleveland Browns hire Todd Monken as head coach (00:36:48) Patrick Reed (00:42:10) Doomsday Clock (00:50:39) Davy CrockettYou can find every episode of this show on Apple Podcasts, Spotify or YouTube. Prime Members can listen ad-free on Amazon Music. For more, visit barstool.link/macrodosing
(0:00) Mike McDaniel's morning routine(7:00) Tom Brady shocked by Bill Belichick's HOF snub(25:00) Robert Kraft says Belichick “deserves to be a first ballot Hall of Famer”(31:00) Bill Polian confirms he voted for Belichick(40:00) HOF voter Vahe Gregorian explains decision to not vote for Belichick(58:00) Pro Football HOF threatens removal of voters for violation of bylaws Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
(0:00) Browns hire Todd Monken(13:30) Bo Nix takes issue with Sean Payton's comments on injuries(21:30) Eric Bieniemy returns to Chiefs as OC(30:00) NFL trivia(32:00) Sam Darnold, Drake Maye limited in practice Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
(0:00) Bill Belichick falls short of first ballot HOF induction (20:00) HOF GM Bill Polian denies telling voters Belichick should have to “wait a year” (35:00) Do other voters believe Belichick shouldn't be a first ballot HOFer? Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
(0:00) More on Belichick (15:00) Jimmy Johnson backs Belichick (20:00) Bills promote Joe Brady to HC (32:30) Steelers introduce Mike McCarthy as HC (41:30) McCarthy on Aaron Rodgers (46:30) Chargers introduce Mike McDaniel as OC (50:30) Sean Payton reflects on AFC Championship loss Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
(0:00) NFC Championship recap(3:00) Rams' failed 4th down conversion(4:00) Sean McVay on failed 4th down(10:00) Sam Darnold's performance vs Rams(11:00) Rams' muffed punt(16:00) Cooper Kupp makes a risky play(23:00) Take Your Pick: Broncos & Rams(29:00) Steelers hire Mike McCarthy as HC(34:30) Jim Schwartz “gaining momentum” to be Browns next HC(37:00) NFL conspiracy theory Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
(0:00) Patriots & Seahawks radio calls(6:00) Should conference championships be played indoors?(14:00) AFC Championship recap(18:00) Chris meets Michael J. Fox over the weekend(26:00) Back to AFC Championship(30:00) Broncos' failed 4th down conversion(40:00) Jarrett Stidham's fumble from 2Q(45:00) Sean Payton on not kicking FG(48:00) Patriots block Broncos' 4Q FG(54:30) Christian Gonzalez 4Q INT (1:00:00) Drake Maye's game-sealing bootleg Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
John Harbaugh is a New York Giant and we talk other coaching news and national sports podcast topics (00:00:00-00:22:43). NFL Divisional round picks and preview, is it Bo Nix's time? Sam Darnold injured? PFT's new stat for Hank and Bear Weather for the Rams (00:22:43-01:19:36). Kyle Long joins the show to talk Divisional weekend, matchups, mismatches and picks + bonus video game talk with Zac (01:19:36-01:59:43). Peter Cowan who went viral for his electrical substation tweet at the Niners Facility joins the show to explain his findings, talk In and Out and how much sunlight we should get (01:59:43-02:21:10). We finish with Fyre Fest of the week and a goodbye to Pug (02:21:10-02:47:43).You can find every episode of this show on Apple Podcasts, Spotify or YouTube. Prime Members can listen ad-free on Amazon Music. For more, visit barstool.link/pardon-my-take