Podcasts about transposable

Notre répondeur Vocal pour laisser un message vocal à Nathalie Wouters, Valérie Renier ou Michel en réaction à ce podcast : https://www.vodio.fr/repondeur/308/ Nathalie Wouters et Valérie Renier: se réconcilier avec sa zone de confort!Et si ralentir était la vraie solution pour avancer ? En cette fin d'année scolaire, on vous propose, lors du prochain évènement Humana, de prendre un temps pour souffler, ralentir et faire le point sur vous, votre rythme, et votre zone de confort.  Parce qu'on a souvent l'impression que sortir de sa zone de confort est le seul chemin vers la réussite, et que, pour être performant, il faut chercher la croissance sans cesse. Mais... et si on apprenait plutôt à se réconcilier avec notre zone de confort ?  Et si le secret, ce n'était pas de pousser toujours plus fort, mais d'adapter son job à sa réalité, de respecter son énergie, de bâtir un quotidien qui nous ressemble… pour un impact durable, sur soi, les autres, et notre entreprise. Que vous soyez salarié·e, indépendant·e, manager, ou chef d'entreprise, vous avez sans doute ce point commun : vouloir vous sentir bien dans ce que vous faites. Et si on vous disait que c'est possible sans tout changer, mais en comprenant mieux votre propre fonctionnement ? C'est pourquoi on vous propose de découvrir le Slowpreunariat, sous l'angle de la zone de confort. Pas seulement réservé aux entrepreneurs un peu perchés (si, si, on vous voit avec vos idées préconçues), le slowpreunariat vise à aligner votre business à qui vous êtes, de façon raisonnée, au lieu de courir derrière la perf comme une poule sans tête. Encore un peu dubitatif ? Écoutez ce podcast hrmeetup.© où Nathalie Wouters et Valérie Renier sont à notre micro pour vous en dire plus sur cet évènement ! Le programme du 5 juin prochain vous permettra d'explorer de façon pratique les éléments suivants : La vision du slowpreneuriat : un business aligné avec soi Comment nourrir un cercle vertueux entre bien-être et performance Ce que signifie réellement votre zone de confort (et ses sous-zones !) Des pistes concrètes pour faire évoluer votre posture et/ou votre environnement pro, au moment parfait avant la pause estivale ! Et comme d'habitude, inspiration, échanges et atelier participatif rythmeront la soirée avec un apéro offert par notre super sponsor Q7Leader et la possibilité de prolonger le moment si vous le souhaitez avec un resto Date : 05 juin 2025 Heure : 18.30 Lieux : Cook&Book Bloc A, Place du temps libre 1, 1200 Woluwé Saint Lambert Faites passer le mot et invitez vos collègues à nous rejoindre! On s'y voit? PS: Nous allons faire des photos et des vidéos pendant cet évènement, pour des raisons de publicités pour nos évènements. Si vous ne souhaitez pas apparaître sur celles-ci, merci de nous en informer dès votre arrivée à l'évènement pour que nous puissions respecter votre choix. Mise à jour 2024 : Les soirées hrmeetup continuent sous un nouveau nom, "Humana". Le nom a changé, mais le concept reste presque le même.  Plus d'infos : https://www.linkedin.com/company/humana-the-community/ Un événement pensé pour vous :Une ambiance fun et décontractée pour échanger librement Des workshops interactifs pour tester de nouvelles approches Des apprentissages concrets applicables immédiatement Liens Utiles :Le lien pour vous inscrire : https://www.eventbrite.be/e/billets-humana-se-reconcilier-avec-sa-zone-de-confort-1353183661759 Site Internet pour Valérie Renier (Value Strategy) : https://www.value-strategy.be Site Internet pour Nathalie Wouters (Tribu Slow) : https://www.tribuslow.com/  Site de Q7 Leader : https://www.q7leader.com/ Liens pour supporter The Podcast Factory Org :Notre lien d'affiliation Podcastics (valable 7 jours après l'avoir ouvert) Notre lien d'affiliation O2Switch pour un hébergement web au top Évaluation de The Podcast Factory Org asbl-vzw via notre fiche Google Faites un don à notre association Un podcast accessible à tou·tes, partout dans le monde.Parce que l'inclusion est au cœur de notre engagement, cet épisode est bien plus qu'un simple podcast. Une transcription intégrale pour les sourd·es et malentendant·es. Un séquençage minutieux pour faciliter la navigation. Un format vidéo pour une immersion totale. Une portée universelle : même si une version en anglais est disponible, grâce à la transcription, ce podcast peut être lu dans toutes les langues du monde ! Une simple extension Google Translate dans Chrome permet d'en traduire chaque mot en un clic. Séquençage du podcast :[00:00:34] Introduction et contexte du podcast [00:01:14] Du rêve d'adolescente à aujourd'hui : Valérie Renier [00:02:33] Du rêve d'adolescente à aujourd'hui : Nathalie Wouters [00:03:13] Le sujet du podcast de Nathalie Wouters [00:03:31] Le sujet de la soirée Humana du 5 juin 2025 [00:04:08] Définition du slowpreneuriat [00:05:52] Slow entrepreneurs, et slow intrapreneurs aussi ? [00:06:36] Comment amener cette thématique au sein d'Humana ? [00:07:38] Des exercices où chacun pourra un peu se positionner ! [00:09:02] Une approche holistique [00:09:21] Des outils au programme ? [00:09:58] Transposable à toutes les entreprises ? [00:11:04] Quel constat à l'origine de cette démarche ? [00:12:06] La source d'inspiration : Laure Dodier [00:12:58] La rencontre entre Valérie Renier et Nathalie Wouters [00:14:29] Comment définir un bon ou une bonne RH ? [00:15:17] Un effet waouh [00:16:25] Un message aux auditeur·ice·s d'hrmeetup© [00:17:05] Clôture de l'épisode podcast

Portable Practices and Transposable Messages: Yoga and Taiji. Professor Paul Bowman (Cardiff University)

Did you know that about half your genome is made of small bits of DNA called transposable elements? These "genomic parasites" are not genes, and they are not there to help run your body... they are small selfish elements out only to replicate themselves. They can cut themselves out of your genome, duplicate and re-enter you genome... and they can disrupt things as they go. Some of them appear to be ancient viruses, now there almost like fossils, some are highly dynamic bits of DNA. They are fascinating selfish elements ... and you are crammed full of them.

Virginie Courtier-OrgogozoBiodiversité et écosystèmes (2022-2023)Collège de FranceColloque - Integrating Evolutionary Genetics and Ecology : Microevolutionary Implications of Transposable Element-Mediated Variation in PlantsVincent Colot, ENS, Paris, France

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.03.535374v1?rss=1 Authors: Truby, N. L., Kim, R. K., Silva, G. M., Qu, X., Picone, J. A., Alemu, R., Neve, R. L., Cui, X., Liu, J., Hamilton, P. J. Abstract: The neurobiological origins of social behaviors are incompletely understood. Here we utilized synthetic biology approaches to reprogram the function of ZFP189, a transcription factor whose expression and function in the rodent prefrontal cortex was previously determined to be protective against stress-induced social deficits. We created novel synthetic ZFP189 transcription factors including ZFP189VPR, which activates the transcription of target genes and therefore exerts opposite functional control from the endogenous, transcriptionally repressive ZFP189WT. Upon viral delivery of these synthetic ZFP189 transcription factors to mouse prefrontal cortex, we observe that ZFP189-mediated transcriptional control promotes mature dendritic spine morphology on transduced pyramidal neurons. Interestingly, dysregulation of ZFP189-mediated transcription in this brain area, achieved by delivery of synthetic ZFP189VPR, precipitates social behavioral deficits in terms of social interaction, motivation, and the cognition necessary for the maintenance of social hierarchy, without other observable behavioral deficits. By performing RNA sequencing in virally manipulated prefrontal cortex tissues, we discover that ZFP189 transcription factors of opposing regulatory function have opposite influence on the expression of genetic transposable elements as well as genes that participate in immune functions. Collectively, this work reveals that ZFP189 function in the prefrontal cortex coordinates structural and transcriptional neuroadaptations necessary for social behaviors by binding transposable element-rich regions of DNA to regulate immune-related genes. Given the evidence for a co-evolution of social behavior and the brain immune response, we posit that ZFP189 may have evolved to augment brain transposon-associated immune function as a way of enhancing an animal's capacity for functioning in social groups. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

In this episode of the Epigenetics Podcast, we caught up with Marco Trizzino from Thomas Jefferson University to talk about his work on transposable elements in gene regulation and evolution. Marco Trizzino and his team focus on characterising transposable elements and how they affect gene regulation, evolution and ageing in primates. They could show that transposable elements that integrated into the genome turned into regulatory elements in the genome, like enhancers. They then contribute to regulation of processes like development or ageing, which could be among those factors that lead to increased brain development or longevity in great apes.   References Trizzino M, Park Y, Holsbach-Beltrame M, Aracena K, Mika K, Caliskan M, Perry GH, Lynch VJ, Brown CD. Transposable elements are the primary source of novelty in primate gene regulation. Genome Res. 2017 Oct;27(10):1623-1633. doi: 10.1101/gr.218149.116. Epub 2017 Aug 30. PMID: 28855262; PMCID: PMC5630026. Pagliaroli L, Porazzi P, Curtis AT, Scopa C, Mikkers HMM, Freund C, Daxinger L, Deliard S, Welsh SA, Offley S, Ott CA, Calabretta B, Brugmann SA, Santen GWE, Trizzino M. Inability to switch from ARID1A-BAF to ARID1B-BAF impairs exit from pluripotency and commitment towards neural crest formation in ARID1B-related neurodevelopmental disorders. Nat Commun. 2021 Nov 9;12(1):6469. doi: 10.1038/s41467-021-26810-x. PMID: 34753942; PMCID: PMC8578637. Tejada-Martinez D, Avelar RA, Lopes I, Zhang B, Novoa G, de Magalhães JP, Trizzino M. Positive Selection and Enhancer Evolution Shaped Lifespan and Body Mass in Great Apes. Mol Biol Evol. 2022 Feb 3;39(2):msab369. doi: 10.1093/molbev/msab369. PMID: 34971383; PMCID: PMC8837823. Young transposable elements rewired gene regulatory networks in human and chimpanzee hippocampal intermediate progenitors. Sruti Patoori, Samantha M. Barnada, Christopher Large, John I. Murray, Marco Trizzino. bioRxiv 2021.11.24.469877; doi: https://doi.org/10.1101/2021.11.24.469877   Related Episodes Enhancer-Promoter Interactions During Development (Yad Ghavi-Helm) Chromatin Organization During Development and Disease (Marieke Oudelaar) Ultraconserved Enhancers and Enhancer Redundancy (Diane Dickel)   Contact Active Motif on Twitter Epigenetics Podcast on Twitter Active Motif on LinkedIn Active Motif on Facebook Email: podcast@activemotif.com

In this episode of the Epigenetics Podcast, we caught up with John Rinn from the University of Colorado in Boulder to talk about his work on the role of lncRNAs in gene expression and nuclear organization. The Rinn Lab pioneered the approach of screening the human genome for long noncoding RNAs (lncRNAs). More recently, the lab has shifted focus from measuring the number of lncRNAs to finding lncRNAs that have a distinct biological function in human health and disease. One example of such a lncRNA is FIRRE, which is present in all animals, however the sequence is not conserved, except for in primates. FIRRE contains many interesting features, such as repeat sequences and CTCF binding sites. In absence of FIRRE, defects in the immune system can be observed and also some brain defects may also be observed.   References Carter, T., Singh, M., Dumbovic, G., Chobirko, J. D., Rinn, J. L., & Feschotte, C. (2022). Mosaic cis-regulatory evolution drives transcriptional partitioning of HERVH endogenous retrovirus in the human embryo. eLife, 11, e76257. Advance online publication. https://doi.org/10.7554/eLife.76257 Long, Y., Hwang, T., Gooding, A. R., Goodrich, K. J., Rinn, J. L., & Cech, T. R. (2020). RNA is essential for PRC2 chromatin occupancy and function in human pluripotent stem cells. Nature Genetics, 52(9), 931–938. https://doi.org/10.1038/s41588-020-0662-x Kelley, D., & Rinn, J. (2012). Transposable elements reveal a stem cell-specific class of long noncoding RNAs. Genome biology, 13(11), R107. https://doi.org/10.1186/gb-2012-13-11-r107 Khalil, A. M., Guttman, M., Huarte, M., Garber, M., Raj, A., Rivea Morales, D., Thomas, K., Presser, A., Bernstein, B. E., van Oudenaarden, A., Regev, A., Lander, E. S., & Rinn, J. L. (2009). Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression. Proceedings of the National Academy of Sciences, 106(28), 11667–11672. https://doi.org/10.1073/pnas.0904715106 Guttman, M., Amit, I., Garber, M., French, C., Lin, M. F., Feldser, D., Huarte, M., Zuk, O., Carey, B. W., Cassady, J. P., Cabili, M. N., Jaenisch, R., Mikkelsen, T. S., Jacks, T., Hacohen, N., Bernstein, B. E., Kellis, M., Regev, A., Rinn, J. L., & Lander, E. S. (2009). Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature, 458(7235), 223–227. https://doi.org/10.1038/nature07672   Related Episodes The Role of lncRNAs in Tumor Growth and Treatment (Sarah Diermeier) The Role of Small RNAs in Transgenerational Inheritance in C. elegans (Oded Rechavi) Chromatin Structure and Dynamics at Ribosomal RNA Genes (Tom Moss)   Contact Active Motif on Twitter Epigenetics Podcast on Twitter Active Motif on LinkedIn Active Motif on Facebook Email: podcast@activemotif.com

* Nature Paper Confirms RSR Rejection of 'Junk' DNA: A landmark study by 440 researchers working in 32 laboratories aro und the world has so far been able to identify function for 80 percent of the human genome! Real Science Radio co-hosts Bob Enyart and Fred Williams also present six minutes of audio from 1998 when leading evolutionist Eugenie Scott tells Bob that genetic scientists were "over the hump" and affirmatively knew that the pseudogenes had no function and that such junk DNA was therefore evidence against the existence of a Designer. Hear the fundamentalist Bible teacher disagree with the degreed scientist, and guess who science has vindicated? * Notice the Nucleotides in the Trash Bags: :) -->* Hear Eugenie Scott & Bob Spar on Junk DNA: At the beginning of this radio program, hear audio from 1998 from Bob and leading anti-creationist Eugenie Scott debating the merits of the Junk DNA argument! (And see more below). Hear also physicist Lawrence Krauss acknowledge to Bob Enyart that his friend Eugenie was wrong. * ENCODE Project Takes Out the Trash: The project leader for ENCODE (the Encyclopedia of DNA Elements) is predicting that eventually, we will learn that "100%" of the genome is functional. (ENCODE Consortium, Dunham, et al., Nature, 2012, pp. 57-74). When the scientist finally reaches the summit, he finds the theologian already there. * Famed Molecular Evolutionist in a Tough Spot: Please pray for Dan Graur. To a young-earth creationist who has been vindicated by ENCODE (and now through 2019 with mountains of consistent data continuously rising up), Dan Graur's angst is our celebration. In 2017 he published, desperately, that based on evolutionary assumptions the human genome cannot be more than at the very most 25% functional. Oh boy. Then in 2019 he acknowledged even more bluntly: If the human genome is indeed devoid of junk DNA as implied by the ENCODE project, then a long, undirected evolutionary process cannot explain the human genome. If, on the other hand, organisms are designed, then all DNA, or as much as possible, is expected to exhibit function. If ENCODE is right, then Evolution is wrong.  * 2019 Worm Update: Worm "junk DNA" turns out to control their ability to regenerate, says Harvard's Evolutionary Biology department. So, even with the worms Dr. Graur, it wasn't junk after all.   For this show, RSR recommends Dr. Don Johnson's Programming of Life DVD! * Junky Real Science Radio Shows - "Nature" Confirms Creationist Rejection of Junk DNA (this webpage) - Bob Debates an Evolutionist 1998 DVD (from our archives) - RSR: Enyart Exhumes Eugenie Scott (2005 radio program: show summary copied here...) * RSR: Bob Debates Ph.D. Evolutionist Eugenie Scott: One of the world's leading anti-creationists vs. Bob Enyart. The debate is decided in the first round, by TKO. That's after Bob asked the well-known scientist for any evidence that any high-level function had ever evolved, like eyesight, or hearing, or flight, or mobility in general? Through the hour-long debate, this evolutionist refused to offer any such evidence but finally settled on a claim of evidence against design, which was: junk DNA! * JUNK DNA: Eugenie Flubs Genetics Prediction, Creationist Hits the Bull's-eye. The negative evidence that Eugenie did offer was Junk DNA. This scientist, from her Darwinist worldview, therefore didn't offer scientific evidence but made this philosophical argument about what a Creator would or would not do; namely, that He wouldn't fill our genome with so much non-protein-coding DNA. While some simple worms have 20,000 genes, it is typically a small portion of DNA that actually codes for proteins. A human has only 20,500 genes, which fills only 2% of our genome. Yet the widespread evolutionary claim for decades (including through the last two decades, and for many, still held today) was that the rest of the genome was left-over evolutionary garbage. Debating this physical anthropologist, Bob Enyart was just a Christian fundamentalist talk show host who spoke from his biblical worldview. Bob argued that our knowledge of genetics was in its infancy, and that it was too early to make the determination that all those non-coding segments of DNA had no function. After this 1998 debate, the next decade of explosive genetic discoveries overwhelmingly validated this creationist perspective, so much so that aside from coding for 20,500 proteins, it is estimated that the remainder of the genome has approximately four million other functional regulatory segments of DNA. So much for junk. Fulfilled predictions, as the world saw with Einstein's 1919 eclipse prediction, go toward scientific credibility. However, Dr. Scott strongly rejected this creationist prediction making an extraordinary claim, which Bob immediately offered her to retract, that scientists currently knew everything they would ever need to know about genetics to conclusively state that all those regions were useless junk. Bob would love a rematch. But Eugenie Scott, (Ph.D. in Physical Anthropology, leading anti-creationist, and director of the National Center for Science Education), who had just debated evolution on a nationwide PBS television program, ended this one-hour program with Bob stating, "Well, I don't debate." * The Diet Pop Junk DNA Syndrome: Junk DNA = Junk Science. Junk DNA was a science stopper. The many Darwinists who strongly pushed (and many still do) the Junk DNA claim predicted that nearly 100% of the entire human genome, the portion that was non-coding, was mostly just left-over junk DNA. It's like a diet cola having NO sugar, NO calories, NO cholesterol, NO fiber, NO protein, NO carbs, NO sodium, NO fat. One wonders what in the world gives it its taste. So from the 1970s it's not surprising, assuming as they did that nearly 95% or so of the DNA was junk anyway, that evolutionists could make such sloppy claims about DNA reinforcing the Darwinian tree. However, now, with the List of Genomes that Just Don't Fit, evolutionary geneticists have falsified the claim that DNA confirms Darwinian predictions. And all that progress aside, the canard that there's nearly a 99% similarity between humans and chimps should have been falsified merely by a careful look at differences in brain and overall anatomy. * Tossing the Wright Brothers Materials and Tools: Consider the significance of the four million regulatory regions of the human genome as compared to the relatively tiny portion that codes for proteins. The creationist Wright Brothers' design, that is, their regulatory input, so-to-speak, dwarfed the importance of the particular kinds of materials and tools that built their airplane. Other tools and materials could suffice. But all the tools and materials in the world assembled for workers who had no design to begin with would not produce an airplane. Thus the regulatory portion of the genome, including that in epigenetics, very possibly may be the more significant part. And similarly, the design concept of a nucleus itself is far more important than what specific chemistry will implement it. * Another Bit of (Famous) Junk DNA Reclassified: (2013 Update.) First consider this analogy from astronomy. Cosmologists cannot show that a big bang could create the contents of the universe because it's impossible to formulate an explanation for the origin of something if you don't know what that something is! And 96% of what's supposedly in a "big bang universe", all that dark matter and dark energy, is of unknown composition. Thus it's no wonder that even the latest textbooks on big bang nucleosynthesis don't even mention, for example, the production of dark matter! Likewise, because geneticists have difficulty even to defining what a "gene" is (see Moran on Dawkins, for example), evolutionists have oversold their case in calling portions of a genome a "pseudogene". As it turns out, a piece of DNA spectacularly referred to as a functionless piece of junk by famed evolutionist Kenneth Miller apparently has important function, according to a 2013 paper in the journal Genome Biology and Evolution. There's a layman's explanation of this issue written by Casey Luskin. Leading evolutionists misunderstood and thus misused the beta-globin "pseudogene" to make what amounts to a religious argument about what a Designer may or may not be inclined to do. As Luskin explains, Darwinists claimed that "matching mistakes" in various species in this "pseudogene" disproved the claim of a designer. But as it turns out, those "matching mistakes" are actually conserved genetic functionality, so that like Darwinist arguments generally, this evolution claim was based on ignorance and it evaporated as science learned more. Additionally, however, (and this gets to the related question of how much marijuana is smoked by leading evolutionists) the theory of neo-Darwinism itself refutes this popular beta-globin pseudogene claim. For if this segment of DNA had no function (i.e., if it were junk) it would NOT have been conserved by natural selection! Mutations over millions of years would have altered any "mistaken" nucleotides. Thus, by the theory itself, we do not expect to see non-functioning segments of DNA with conserved sequences of junk that arose from mutations over millions of years. Thus, the fact that these segments were conserved pointed directly to their being conserved, and functional (and, by the way, to their being designed). * Can Evolution Proceed One Small Step at a Time? If it is true that there are no "small steps," logically or physically, between monochromatic and dichromatic vision, then at least for this wildly complex vision-system upgrade, Richard Dawkins' Mt. Improbable must be scaled in one huge step. And scaling such a complexity cliff in one step, he himself admits, would be very difficult to advocate. There are no Darwin-friendly small steps between eukaryote (nucleus) and prokaryote (no nucleus), nor between invertebrate and vertebrate, nor between monochromatic and dichromatic vision. Whether you are an extinct fossil or a living species, you either have a backbone or you don't; you either have a nucleus or you don't, you might have monochromatic or dichromatic vision, or not, but you don't have something in between. Post-show Note: Illustrating this nicely the Wikipedia article on transposons states, ironically that transposition elements, "are often considered 'junk DNA'. In Oxytricha... they play a critical role..." And from Scientific American, "The term 'junk DNA' repelled mainstream researchers from studying noncoding genetic material for many years." Today's Resource: Get the greatest cell biology video ever made! Getting this on DVD: - helps you to share it with others - helps keep Real Science Radio on the air, and - gets you Dr. Don Johnson's book as a bonus! Information is encoded in every cell in our DNA and in all living things. Learn how the common worldview of life's origin, chemical evolution, conflicts with our knowledge of Information Science. Finally, information Science is changing the way millions of people think about all living systems! Also, have you browsed through our Science Department in the KGOV Store? You just might LOVE IT! 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L'After foot, c'est LE show d'après-match et surtout la référence des fans de football depuis 15 ans ! Les rencontres se prolongent tous les soirs avec Gilbert Brisbois et Nicolas Jamain avec les réactions des joueurs et entraîneurs, les conférences de presse d'après-match et les débats animés entre supporters, experts de l'After et auditeurs. RMC est une radio généraliste, essentiellement axée sur l'actualité et sur l'interactivité avec les auditeurs, dans un format 100% parlé, inédit en France. La grille des programmes de RMC s'articule autour de rendez-vous phares comme Apolline Matin (6h-9h), les Grandes Gueules (9h-12h), Estelle Midi (12h-15h), Super Moscato Show (15h-18h), Rothen s'enflamme (18h-20h), l'After Foot (20h-minuit).

Jumping genes, fighting stigmas, and a passion for music! We had such a great time talking with rising junior Mahek about her project, future ambitions and interests outside of uni. Her research investigating the potential role of transposable elements in the phenomenon of speciation was intriguing to learn about, along of course learning all about her dedication and passion for research, integrated with her commitment and love for patient care and interaction as an aspiring physician associate. Have a great day and as always remember: You've Got Potential! Connect with Us! Fill out this form to get a sneak peak of our guest speaker's background before their episode comes out (and a chance to ask them some questions): https://forms.gle/4qNaWAiauLrv55kD7 Interested in being a guest speaker? Fill out the form here: https://docs.google.com/forms/d/e/1FAIpQLSfgmUsRBm1UnRvQwvJsqAKyEaukRdrB-Bqiw_7WdSbAKOartg/viewform?usp=send_form Follow our Social Media! Instagram: @youve.got.potential Facebook: You've Got Potential Linktree: https://linktr.ee/youvegotpotential #youvegotpotentialpodcast #undergraduateresearch #womeninstem

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.11.19.389718v1?rss=1 Authors: Casale, A. M., Liguori, F., Ansaloni, F., Finaurini, S., Spirito, G., Persichetti, F., Sanges, R., Gustincich, S., Piacentini, L. Abstract: Huntington's disease (HD) is a late-onset, autosomal dominant disorder characterized by progressive motor dysfunction, cognitive decline and psychiatric disturbances. The most prominent pathological manifestation is a selective loss of medium-sized spiny neurons of the striatum. The disease is caused by a CAG repeat expansion in the IT15 gene, which elongates a stretch of polyglutamine at the amino-terminal of the HD protein, Huntingtin (Htt). Despite the accumulation of an impressive amount of data on the molecular basis of neurodegeneration, no therapeutic treatments are available and new pharmacological targets are needed. Transposable Elements (TEs) are mobile genetic elements that constitute a large fraction of eukaryotic genomes. Retrotransposons (RTEs) replicate through an RNA intermediate and represent approximately 40% and 30% of the human and Drosophila genomes. Mounting evidence suggests that mammalian RTEs are normally active during neurogenesis and may be involved in diseases of the nervous system. Here we show that TE expression and mobilization are increased in a Drosophila melanogaster HD model. By inhibiting TE mobilization with Reverse Transcriptase inhibitors, polyQ-dependent eye neurodegeneration and genome instability in larval brains are rescued and fly lifespan is increased. These results suggest that TE activation may be involved in polyQ-induced neurotoxicity and a potential pharmacological target. Copy rights belong to original authors. Visit the link for more info

How do transposable elements contribute to gene and genome evolution, and what are the benefits of a hands-on laboratory education for undergraduates? Dr. Sue Wessler, a Professor of Genetics at the University of California Riverside and Home Secretary of the National Academy of Sciences (NAS), discusses her career researching fragments of DNA that can insert into new chromosomal locations, how she has helped to make the NAS more inclusive, and the Dynamic Genome course-based undergraduate research experience that she developed and implemented at two universities! Learn more about the Wessler Lab at wesslerlab.ucr.edu. Learn more about the students producing this podcast and their science communication efforts by following us on Twitter @SciCommUCR and visiting our website.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.07.23.218800v1?rss=1 Authors: He, J., Babarinde, I. A., Sun, L., Xu, S., Chen, R., Wei, Y., Li, Y., Ma, G., Zhuang, Q., Hutchins, A., Chen, J. Abstract: Transposable elements (TEs) make up a majority of a typical eukaryote's genome, and contribute to cell heterogeneity and fate in unclear ways. Single cell-sequencing technologies are powerful tools to explore cells, however analysis is typically gene-centric and TE activity has not been addressed. Here, we developed a single-cell TE processing pipeline, scTE, and report the activity of TEs in single cells in a range of biological contexts. Specific TE types were expressed in subpopulations of embryonic stem cells and were dynamically regulated during pluripotency reprogramming, differentiation, and embryogenesis. Unexpectedly, TEs were expressed in somatic cells, including human disease-specific TEs that are undetectable in bulk analyses. Finally, we applied scTE to single cell ATAC-seq data, and demonstrate that scTE can discriminate cell type using chromatin accessibly of TEs alone. Overall, our results reveal the dynamic patterns of TEs in single cells and their contributions to cell fate and heterogeneity. Copy rights belong to original authors. Visit the link for more info

En este primer episodio hablamos de las posibilidades que tendremos en unos años (o no) de sobrevivir a la muerte. También hablaremos de Altered Carbon, Blade Runner, Westworld y Armageddon. Comentaremos tecnologías que hemos visto en la ciencia ficción y que querríamos tener ya y otras que, por el contrario, no querríamos tener nunca. Referencias: Arias, E et al. (2013). United States life tables eliminating certain causes of death, 1999-2001. National Vital Statistics Reports 61(9) De Cecco, M. et al. (2013). Transposable elements become active and mobile in the genomes of aging mammalian somatic tissues. Aging 5(12): 867-883. DOI 10-18622/aging.100621 Martinez, D.E. (1998). Longevity of lobsters is linked to ubiquitous telomerase expressions. FEBS Letters 439: 143-146 Roth, A.W. And Polotsky, A.J. (2012). Can we live longer by eating less? A review of caloric restriction and longevity. Maturitas 71:315-310 Destruir un asteroide no es tan fácil como en las películas Esperamos vuestros comentarios en cienciaoficcion.com. También podéis contactar con nosotros a través de Twitter en: @cienciaoficcion @wavensdorvad @orbitagrana O en Facebook Escúchalo en tu aplicación favorita

Mia joins Nels and Vincent to unravel their finding that the transposons that maintain the ends of chromosomes in Drosophilahave evolved in conflict with the genome. Hosts: Nels Elde and Vincent Racaniello Guest: Mia Levine Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiEVO Levine Lab at U Penn Telomere elongation without telomerase (bioRxiv) Letters read on TWiEVO 36 Science Picks Nels - Cinema Science podcast Vincent - Mastodon bones unearthed (Instagram, Grand Rapids News) Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

The TWiVodrome explains how a gag-like protein from a retrotransposon forms virus-like particles that carry mRNA  within vesicles across the synapse. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Become a patron of TWiV! Links for this episode ASV 2018: asv.org, asv2018.umd.edu Arc virus-like particles transport RNA across the synapse (mammalian, Drosophila) Chemical synapse (Wikipedia) 2 minute video on the neuron Image credit Letters read on TWiV 477 Weekly Science Picks Kathy - Ice cliffs form over the weekend Rich - The Courage To Invent: A NASA Roboticist Tells Her Story (Ayanna Howard) Dickson - 2017 Was One of the Hottest Years on Record Alan - Experimenter gender and replicability Vincent - Set Your Autocorrect to Change 'Guys' to 'Folks' Listener Picks Asal - 100 million chickens with avian flu Mark - Dr. Tatiana's Sex Advice to All Creation Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Maitreya Dunham joins Nels and Vincent to explain how her laboratory uses experimental evolution to study yeast flocculation, the community-building cell aggregation trait. Hosts: Nels Elde and Vincent Racaniello Guest: Maitreya Dunham Become a patron of TWiEVO Dunham Laboratory Adaptive Routes to Cell Aggregation in Yeast (Genetics) Making the best of a sticky situation (SGD) Yeast Genetics and Genomic Course (Cold Spring Harbor) Genetic basis of biofilm formation (Beacon) 2017 CSH Plate Race (YouTube) Image credit This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twie. Science Picks Nels - Floating Fire Ant Colonies in Houston and Help for Houston Researchers Vincent - Help People Affected by Harvey and How To Help Harvey Victims Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv

Le Bangladesh est le pays du monde le plus impacté par le changement climatique. Parmi les conséquences concrètes, les îles éphémères au nord du pays : elles disparaissent et resurgissent au gré des crues du fleuve Brahmapoutre, de plus en plus fréquentes en raison de la fonte des glaciers de l'Himalaya. Pour y faire face, les habitants de ces îles ont appris à être mobiles, construisant des maisons – et des écoles – pouvant être démontées à la première alerte.

Hosts: Nels Elde and Vincent Racaniello Nels and Vincent review experiments showing that the replacement of a pale moth with a black one during the industrial revolution was caused by a transposable element.   Links for this episode Last experiment of Michael Majerus (Biol Lett) Moth melanism mutation is transposon (Nature) Image credit Letters read on TWiEVO 10 Science Picks Nels - Is Pokémon Go good for science? (one, two, three) Vincent - Seven Brief Lessons on Physics by Carlo Rovelli Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv Become a patron of TWiEVO

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove and Kathy Spindler Guests: Nels Elde and Edward Chuong Nels and Ed join the TWiV team to talk about their observation that regulation of the human interferon response depends on regulatory sequences that were co-opted millions of years ago from endogenous retroviruses.   Links for this episode Endogenous retroviruses and regulation of innate immunity (Science) Placenta is viral (Nature) An ERV that maintains pluripotency of human embryonic stem cells (TWiV 279) Letters read on TWiV 382 This episode is sponsored by ASM Agar Art Contest and ASV 2016 Weekly Science Picks Nels - Don't Get Me Started - Matt GiorgianniAlan - Sun's magnetic field (paper)Dickson - Most realistic dinosaur terrifiesVincent - Top secret!Kathy - Zika virus risk for US 50 cities (paper)Ed - Watching comb jellies poop Listener Picks Asal - Lost paper of Gregor MendelDennis - PhysicsGirlJacob - Second (XKCD) and ACI blogger interview Send your virology questions and comments to twiv@microbe.tv