Podcasts about cech

            The Catalyst: RNA and the Quest to Unlock Life's Deepest Secrets     CU Boulder Nobel Prize-Winning Scientist Tom Cech says that RNA has long been the biochemical backup singer that slaves away in the shadows of the diva.  In his new book, The Catalyst, Cech puts RNA in the spotlight, … Continue reading "Tom Cech: The Catalyst"

Amerika se zcela zjevně rozhodla dál nebýt spojencem Evropy. Je to fakt, který je nutné akceptovat a začít se podle toho chovat. To je asi to nejzásadnější sdělení bezpečnostní konference v Mnichově, kterou celý svět v posledních dnech sledoval.

Potkal jsem nedávno kamaráda, spisovatele, známého tím, že při každém hovoru zmíní, koho zná, s kým si píše, kdo o něm co řekl. A nezklamal ani tentokrát.Všechny díly podcastu Rozhlasový sloupek můžete pohodlně poslouchat v mobilní aplikaci mujRozhlas pro Android a iOS nebo na webu mujRozhlas.cz.

In this episode, Jenn Wisdahl, Chief Operating Officer at the non-profit FASD United, and Laura Bousquet, a mother to a young adult son diagnosed with FASD in his teens, join host Chris Stallman, CGC to discuss challenges many families with lived FASD experience face. Wisdahl leads FASD United's legislative and policy agenda and trains members of the FASD community to serve as advocates. She was also an executive producer on the award-winning short film “The FASD Project,” and is a proud parent to 3 young adults with FASD. Bousquet is a passionate FASD advocate and active FASD United Board member whose own FASD diagnosis at age 57 deepened her dedication to inspiring positive change in the FASD community. BONUS: Earn continuing education credits for listening to our series. Scroll down to learn more. Resources Mentioned in This Episode: FASD Family Navigator - FASD United https://fasdunited.org/family-navigator/ Resource Directory - FASD United https://fasdunited.org/resource-directory/ Glimpses of FASD - FASD United https://fasdunited.org/glimpses-of-fasd/  Give FASD a Seat at the Table - FASD United https://fasdunited.org/give-fasd-a-seat-at-the-table/  FASD State Data Sheets - FASD United https://fasdunited.org/fasd-state-data-sheets/ Video Series: Lived Experiences with Fetal Alcohol Spectrum Disorders - CDC https://www.cdc.gov/fasd/stories/video-series.html    MotherToBaby: FASD Podcast - Living with FASDs - January 23, 2025 (Podcast) - PD4929-012325 PROGRAM DESCRIPTION: This podcast series is intended to reach various audiences, including healthcare professionals, who can use the information presented to inform their practice and their interaction with clients/patients. The podcast episodes will educate participants on 1) the discovery, prevalence, and newest research on the topic of fetal alcohol spectrum disorders (FASDs), 2) CDC's work in addressing prenatal alcohol and other substance use and FASDs, and 3) the experiences of people living with FASDs. OBJECTIVES: After completing this course, the learner will be able to: 1.      Describe Fetal Alcohol Spectrum Disorders (FASDs). 2.      Describe the National Center of Birth Defects and Developmental Disabilities' (NCBDDD) approach to addressing FASDs. 3.      Describe the impact on people who are living with FASDs. 4.      Describe how interprofessional collaboration addresses FASDs. 5.      Describe how interprofessional teams can help people living with FASDs transition from pediatric to adult healthcare.   FACULTY/                                                   CREDENTIALS: Laura Bousquet, Family Navigator/Self-Advocate, FASD United Christina Chambers, PhD, MPH, Distinguished Professor of Pediatrics, University of California, San Diego Elizabeth Dang, MPH, Behavioral Scientist, Centers for Disease Control and Prevention Nicholas Deputy, PhD, MPH, Health Scientist, Centers for Disease Control and Prevention Kenneth Jones, MD, Distinguished Professor of Pediatrics, University of California, San Diego  Chris Stallman, MLS, MS, CGC, Director,    MotherToBaby Arizona, University of Arizona  Jennifer Wisdahl, Chief Operating Officer, FASD   United   CE ORIGINATION DATE: CE EXPIRATION DATE:   January 23, 2025 January 23, 2027     URL   https://momtobaby.org/youtubeFASDfamilies   INTENDED AUDIENCE:   Advanced Practice Nurses, Certified Health Educators, Medical Assistants, Licensed Practical/Vocational Nurses, Physicians, Physician Assistants, Registered Nurses, and Social Workers   PREREQUISITES:   Learners will have a basic understanding of what fetal alcohol spectrum disorders are.   FORMAT: This activity is Web on Demand   CONTACT INFORMATION: CDC's CE Accreditation Team has a policy for grievances that is available upon request.   Division of Birth Defects and Infant Disorders cdcinfo@cdc.gov   ACCREDITATION STATEMENTS:       In support of improving patient care, this activity has been planned and implemented by the Centers for Disease Control and Prevention MotherToBaby. The Centers for Disease Control and Prevention is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team   CME: The Centers for Disease Control and Prevention designates this enduring activity for a maximum of 0.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. CNE: The Centers for Disease Control and Prevention designates this activity for 0.5 nursing contact hours. CEU: The Centers for Disease Control and Prevention is authorized by IACET to offer 0.1 CEU's for this program. CECH: Sponsored by the Centers for Disease Control and Prevention, a designated provider of continuing education contact hours (CECH) in health education by the National Commission for Health Education Credentialing, Inc. This program is designated for Certified Health Education Specialists (CHES®) and/or Master Certified Health Education Specialists (MCHES®) to receive up to 0.5 total Category I continuing education contact hours. Maximum advanced level continuing education contact hours available are 0. Continuing Competency credits available are 0.5. CDC provider number 98614. DISCLOSURE: In compliance with continuing education requirements, all planners and presenters must disclose all financial relationships, in any amount, with ineligible companies during the previous 24 months as well as any use of unlabeled product(s) or products under investigational use.    CDC, our planners, and content experts wish to disclose they have no financial relationship(s) with ineligible companies whose primary business is producing, marketing, selling, reselling, or distributing healthcare products used by or on patients. Content will not include any discussion of the unlabeled use of a product or a product under investigational use. CDC did not accept financial or in-kind support from ineligible companies for this continuing education activity. The Centers for Disease Control and Prevention (CDC) complies with applicable Federal civil rights laws and does not discriminate based on race, color, national origin, age, disability, religion, or sex (including pregnancy, sexual orientation, and gender identity). To learn more visit: https://www.hhs.gov/civil-rights/for-individuals/nondiscrimination/index.html.   Instructions for Obtaining Continuing Education (CE) To receive continuing education (CE) for MotherToBaby: FASD Podcast - Living with FASDs - January 23, 2025 (Podcast) - PD4929-012325, please visit CDC TRAIN and search for the course in the Course Catalog using PD4929-012325 Follow the steps below by January 23, 2027. Register for and complete the course. Pass the post-assessment at 75 %. Complete the evaluation. Visit Your Learning to access your certificates and transcript. FEES: No fees are charged for CDC's CE activities. ________________________________________________________________________________ Looking for even more education about FASD? Don't miss a special free Birth Defects Awareness Month webinar January 31, 2025 at 9a PT/12p ET. The webinar will be presented by Dr. Noemi Spinazzi of the American Academy of Pediatrics. It is a free webinar, but advanced registration is required at the following link: https://momtobaby.org/FASDwebinar2025

- Będzie to prezydentura bardzo burzliwa. Będzie to prezydentura łamania reguł, które obowiązywały dotychczas i w polityce wewnętrznej i, może jeszcze bardziej, w polityce międzynarodowej Stanów Zjednoczonych. Tak naprawdę jedyną cechą, o której wiemy na pewno, że ta prezydentura będzie miała, to jest jej nieprzewidywalność i pewien jej arbitralny charakter - mówił dr Jacek Kucharczyk z Instytutu Spraw Publicznych. Gościem programu Joanny Ćwiek-Śwideckiej #RZECZoPOLITYCE był dr Jacek Kucharczyk, Instytut Spraw Publicznych Więcej na stronie: rp.pl Twitterze: twitter.com/rzeczpospolita Facebooku: facebook.com/dziennikrzeczpospolita Linkedin: linkedin.com/company/rzeczpospolita

Coraz częściej słyszymy o tym, że lider potrzebuje być inkluzywny, ale co to znaczy inkluzywny? To znaczy, że jaki jest i co robi? Dzisiaj rozwiązujemy tę zagadkę wraz z Klaudią Jaworską. Porozmawiamy o tym, co to znaczy inkluzywny lider oraz jakie konkretnie oznacza to cechy i zachowania.Wpis blogowy do tego odcinka znajdziesz na stronie: www.okrokdoprzodu.pl/083Czego dowiesz się z tego odcinka:Jakie cechy wyróżniają inkluzywnego lidera?Co to w ogóle znaczy "inkluzywny"?Jak rozwijać samoświadomość, inteligencję kulturową czy ciekawość?O roli odporności psychicznej u liderówCo daje myślenie systemowe i dlaczego jest potrzebne?Jak humor może wspierać działania lidera?Gdy będziesz słuchać tego odcinka, pomyśl o osobie, która też wysłuchałaby go z korzyścią dla siebie lub swojego zespołu i podziel się linkiem do nagrania.Przyjemności ze słuchania życzy Monika Chutnik.Chcesz być na bieżąco? Zapisz się do newslettera: www.okrokdoprzodu.pl/newsletter

In the second episode of the fetal alcohol spectrum disorders (FASD) special series, we explore the Centers for Disease Control and Prevention's work addressing FASD and how scientific findings are helping shape prevention efforts. BONUS: Earn continuing education credits for listening. Scroll down to learn more. Resources Mentioned in This Episode: About CDC's National Center on Birth Defects and Developmental Disabilities About Fetal Alcohol Spectrum Disorders  What CDC Is Doing: FASDs  Online Trainings and Resources FASD National Partner Network Toolkit  Video Series: Lived Experiences with Fetal Alcohol Spectrum Disorders  “Let's Talk” Materials Toolkit  _________________________________________________________ MotherToBaby: FASD Podcast - CDC's Work Addressing Prenatal Alcohol and Other Substance Use and FASDs - January 16, 2025 (Podcast) - PD4929-011625 PROGRAM DESCRIPTION: This podcast series is intended to reach various audiences, including healthcare professionals, who can use the information presented to inform their practice and their interaction with clients/patients. The podcast episodes will educate participants on 1) the discovery, prevalence, and newest research on the topic of fetal alcohol spectrum disorders (FASDs), 2) CDC's work in addressing prenatal alcohol and other substance use and FASDs, and 3) the experiences of people living with FASDs. OBJECTIVES: After completing this course, the learner will be able to: 1.      Describe Fetal Alcohol Spectrum Disorders (FASDs). 2.      Describe the National Center of Birth Defects and Developmental Disabilities' (NCBDDD) approach to addressing FASDs. 3.      Describe the impact on people who are living with FASDs. 4.      Describe how interprofessional collaboration addresses FASDs. 5.      Describe how interprofessional teams can help people living with FASDs transition from pediatric to adult healthcare.   FACULTY/                                                   CREDENTIALS: Laura Bousquet, Family Navigator/Self-Advocate, FASD United Christina Chambers, PhD, MPH, Distinguished Professor of Pediatrics, University of California, San Diego Elizabeth Dang, MPH, Behavioral Scientist, Centers for Disease Control and Prevention Nicholas Deputy, PhD, MPH, Health Scientist, Centers for Disease Control and Prevention Kenneth Jones, MD, Distinguished Professor of Pediatrics, University of California, San Diego Chris Stallman, MLS, MS, CGC, Director,    MotherToBaby Arizona, University of Arizona  Jennifer Wisdahl, Chief Operating Officer, FASD   United   CE ORIGINATION DATE: CE EXPIRATION DATE:   January 16, 2025 January 16, 2027     URL   https://momtobaby.org/FASDep82YouTube   INTENDED AUDIENCE:   Advanced Practice Nurses, Certified Health Educators, Medical Assistants, Licensed Practical/Vocational Nurses, Physicians, Physician Assistants, Registered Nurses, and Social Workers   PREREQUISITES:   Learners will have a basic understanding of what fetal alcohol spectrum disorders are.   FORMAT: This activity is Web on Demand   CONTACT INFORMATION: CDC's CE Accreditation Team has a policy for grievances that is available upon request.   Division of Birth Defects and Infant Disorders cdcinfo@cdc.gov   ACCREDITATION STATEMENTS:       In support of improving patient care, this activity has been planned and implemented by the Centers for Disease Control and Prevention MotherToBaby. The Centers for Disease Control and Prevention is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team   CME: The Centers for Disease Control and Prevention designates this enduring activity for a maximum of 0.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. CNE: The Centers for Disease Control and Prevention designates this activity for 0.5 nursing contact hours. CEU: The Centers for Disease Control and Prevention is authorized by IACET to offer 0.1 CEU's for this program. CECH: Sponsored by the Centers for Disease Control and Prevention, a designated provider of continuing education contact hours (CECH) in health education by the National Commission for Health Education Credentialing, Inc. This program is designated for Certified Health Education Specialists (CHES®) and/or Master Certified Health Education Specialists (MCHES®) to receive up to 0.5 total Category I continuing education contact hours. Maximum advanced level continuing education contact hours available are 0. Continuing Competency credits available are 0.5. CDC provider number 98614. DISCLOSURE: In compliance with continuing education requirements, all planners and presenters must disclose all financial relationships, in any amount, with ineligible companies during the previous 24 months as well as any use of unlabeled product(s) or products under investigational use.    CDC, our planners, and content experts wish to disclose they have no financial relationship(s) with ineligible companies whose primary business is producing, marketing, selling, reselling, or distributing healthcare products used by or on patients. Content will not include any discussion of the unlabeled use of a product or a product under investigational use. CDC did not accept financial or in-kind support from ineligible companies for this continuing education activity. The Centers for Disease Control and Prevention (CDC) complies with applicable Federal civil rights laws and does not discriminate based on race, color, national origin, age, disability, religion, or sex (including pregnancy, sexual orientation, and gender identity). To learn more visit: https://www.hhs.gov/civil-rights/for-individuals/nondiscrimination/index.html. Instructions for Obtaining Continuing Education (CE) To receive continuing education (CE) for MotherToBaby: FASD Podcast - CDC's Work Addressing Prenatal Alcohol and Other Substance Use and FASDs - January 16, 2025 (Podcast) - PD4929-011625, please visit CDC TRAIN and search for the course in the Course Catalog using PD4929-011625 Follow the steps below by January 16, 2027. Register for and complete the course. Pass the post-assessment at 75 %. Complete the evaluation. Visit Your Learning to access your certificates and transcript. FEES: No fees are charged for CDC's CE activities. _________________________________________________________ Looking for even more education about FASD? Don't miss a special free Birth Defects Awareness Month webinar January 31, 2025 at 9a PT/12p ET. The webinar will be presented by Dr. Noemi Spinazzi of the American Academy of Pediatrics. It is a free webinar, but advanced registration is required at the following link: https://momtobaby.org/FASDwebinar2025

In this episode, Dr. Kenneth Lyons Jones, one of the pioneers who first identified Fetal Alcohol Spectrum Disorders (FASD) in the United States in 1973, and Dr. Christina Chambers, a renowned epidemiologist who has conducted groundbreaking research on the prevalence of FASD, join host Chris Stallman, CGC, to discuss the discovery of FASD, its common physical and cognitive traits, and its prevalence today. BONUS: Earn continuing education credits for listening to our entire FASD 3-part series. Scroll down to learn more. Resources Mentioned in This Episode: Dr. Kenneth Lyons Jones on the History of Fetal Alcohol Syndrome - FASD  Prevalence of Fetal Alcohol Spectrum Disorders in 4 US Communities | Antenatal Exposures and Child Outcomes | JAMA | JAMA Network  Fetal Alcohol Spectrum Disorders – American Academy of Pediatrics Types of Treatment for FASDs | Fetal Alcohol Spectrum Disorders | CDC Choline supplements in young children with fetal alcohol spectrum disorder have lasting cognitive benefits | National Institute on Alcohol Abuse and Alcoholism (NIAAA)  _______________________________________________________________________________________________________ MotherToBaby: FASD Podcast SCPD4929     PROGRAM DESCRIPTION: This podcast series is intended to reach various audiences, including healthcare professionals, who can use the information presented to inform their practice and their interaction with clients/patients. The podcast episodes will educate participants on 1) the discovery, prevalence, and newest research on the topic of fetal alcohol spectrum disorders (FASDs), 2) CDC's work in addressing prenatal alcohol and other substance use and FASDs, and 3) the experiences of people living with FASDs. OBJECTIVES: After completing this course, the learner will be able to: 1.      Describe Fetal Alcohol Spectrum Disorders (FASDs). 2.      Describe the National Center of Birth Defects and Developmental Disabilities' (NCBDDD) approach to addressing FASDs. 3.      Describe the impact on people who are living with FASDs. 4.      Describe how interprofessional collaboration addresses FASDs. 5. Describe how interprofessional teams can help people living with FASDs transition from pediatric to adult healthcare.   FACULTY/                                                   CREDENTIALS: Laura Bousquet, Family Navigator/Self-Advocate, FASD United Christina Chambers, PhD, MPH, Distinguished Professor of Pediatrics, University of California, San Diego Elizabeth Dang, MPH, Behavioral Scientist, Centers for Disease Control and Prevention Nicholas Deputy, PhD, MPH, Health Scientist, Centers for Disease Control and Prevention Kenneth Jones, MD, Distinguished Professor of Pediatrics, University of California, San Diego  Chris Stallman, MLS, MS, CGC, Director,    MotherToBaby Arizona, University of Arizona  Jennifer Wisdahl, Chief Operating Officer, FASD   United   CE ORIGINATION DATE: CE EXPIRATION DATE:   January 9, 2025 January 9, 2027     URL   https://momtobaby.org/FASDep81youtube   INTENDED AUDIENCE:   Advanced Practice Nurses, Certified Health Educators, Medical Assistants, Licensed Practical/Vocational Nurses, Physicians, Physician Assistants, Registered Nurses, and Social Workers   PREREQUISITES:   Learners will have a basic understanding of what fetal alcohol spectrum disorders are.   FORMAT: This activity is Web on Demand   CONTACT INFORMATION: CDC's CE Accreditation Team has a policy for grievances that is available upon request.   Division of Birth Defects and Infant Disorders cdcinfo@cdc.gov    ACCREDITATION STATEMENTS:     In support of improving patient care, this activity has been planned and implemented by the Centers for Disease Control and Prevention and MotherToBaby. The Centers for Disease Control and Prevention is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team   CME: The Centers for Disease Control and Prevention designates this enduring activity for a maximum of 0.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. CNE: The Centers for Disease Control and Prevention designates this activity for 0.5 nursing contact hours. CEU: The Centers for Disease Control and Prevention is authorized by IACET to offer 0.1 CEU's for this program. CECH: Sponsored by the Centers for Disease Control and Prevention, a designated provider of continuing education contact hours (CECH) in health education by the National Commission for Health Education Credentialing, Inc. This program is designated for Certified Health Education Specialists (CHES®) and/or Master Certified Health Education Specialists (MCHES®) to receive up to 0.5 total Category I continuing education contact hours. Maximum advanced level continuing education contact hours available are 0. Continuing Competency credits available are 0.5. CDC provider number 98614. DISCLOSURE: In compliance with continuing education requirements, all planners and presenters must disclose all financial relationships, in any amount, with ineligible companies during the previous 24 months as well as any use of unlabeled product(s) or products under investigational use.    CDC, our planners, and content experts wish to disclose they have no financial relationship(s) with ineligible companies with the exception of Dr. Christina Chambers, PhD, MPH and she wishes to disclose she receives research funding from Amgen, AstraZeneca, GlaxoSmithKline, Janssen Pharmaceuticals, Pfizer, Inc., Regeneron, Hoffman La-Roche-Genentech, Genzyme Sanofi-Aventis, Takeda Pharmaceutical Company Limited, Sanofi, UCB Pharma, USA, Leo Pharma, Sun Pharma Global FZE, Gilead, Novartis, and the Gerber Foundation.  All relevant financial relationships listed for this individual have been mitigated. Content will not include any discussion of the unlabeled use of a product or a product under investigational use. CDC did not accept financial or in-kind support from ineligible companies for this continuing education activity. The Centers for Disease Control and Prevention (CDC) complies with applicable Federal civil rights laws and does not discriminate based on race, color, national origin, age, disability, religion, or sex (including pregnancy, sexual orientation, and gender identity). To learn more visit: https://www.hhs.gov/civil-rights/for-individuals/nondiscrimination/index.html. Instructions for Obtaining Continuing Education (CE) To receive continuing education (CE) for SCPD4929 – MotherToBaby: FASD Podcast, please visit CDC TRAIN and search for the course in the Course Catalog using SCPD4929 Follow the steps below by January 9, 2027. Register for and complete the course. Pass the post-assessment at 75 %. Complete the evaluation. Visit Your Learning to access your certificates and transcript.   FEES: No fees are charged for CDC's CE activities.   ______________________________________________________________________ Looking for even more education about FASD? Don't miss a special free Birth Defects Awareness Month webinar January 31, 2025 at 9a PT/12p ET. The webinar will be presented by Dr. Noemi Spinazzi of the American Academy of Pediatrics. It is a free webinar, but advanced registration is required at the following link: https://momtobaby.org/FASDwebinar2025

Aktuální dění očima Jana Krause každé ráno 5:00 – 9:00 vždy po zprávách v celou a v půl exkluzivně na Frekvenci 1. Vtipně, originálně a s nadhledem, tak to umí jenom Jan Kraus. Blondýna Miluška Bittnerová se ptá na vše, o čem se mluví, a Jan Kraus jí to vysvětlí.

„Já vidím evidentní, dlouhodobou krizi západní civilizace. A zdůrazňuji, že vždycky, když mluvím o destrukci Západu, mluvím o sebedestrukci Západu. Já si myslím, že Západ není destruován tím, co dělá Východ, nebo Jih, ale my sami si pod sebou podřezáváme větev," říká prezident Václav Klaus v rozhovoru pro pořad Kupředu do minulosti. 01.01.2025, www.RadioUniversum.cz

Publikaci Myšlenkování v zahradách bohů, snílků a filosofů, jejímž autorem je Vladislav Dudák, představuje knihovnice Helena Chrastinová. „Eseje, které zazněly v rozhlase, autor doplnil a vždycky jim dal zajímavý závěr, takové poselství každodenních lidských úvah o věcech obyčejných,“ říká. Dále pořad přináší rozhovor o vzniku audioknihy, která zachycuje korespondenci Wericha a Voskovce.Všechny díly podcastu O knihách s knihovnicí můžete pohodlně poslouchat v mobilní aplikaci mujRozhlas pro Android a iOS nebo na webu mujRozhlas.cz.

Voice: Magdaléna Studená, Magda Neporová, Štěpán Švagr, Petr Hegedűs

“The reality is that there are power differentials between a student, a junior scholar and a full professor, or between a medical assistant, a patient, and a physician. But recognizing those power dynamics, if you are in a position of power, really using your privilege, your position as a gatekeeper to speak up and intervene or to give platform to folks that may have less access to power to intervene.”- Khadijah Ameen Drs. Khadijah Ameen and Collins Airhihenbuwa share their work on how to expand how we think about bystanders and perpetrators of racial violence, and how bystander behavioural approaches can be used to intervene. They bring in antiracism frameworks such as the Public Health Critical Race Praxis and the PEN-3 Cultural Model to illustrate their points using some antiracism bystander intervention scenarios. This episode references the article “Expanding Bystander Behavioural Approaches to Address Racial Violence in Health Research, Pedagogy, and Practice” by Khadijah Ameen and Collins Airhihenbuwa. LAST CHANCE: The Health Education Specialist Practice Analysis (HESPA) III is live now and closes this weekend! Take the survey here: https://ow.ly/bYqz50TfuJ1. Complete the survey and receive 2 CECH and earn eligibility to win up to $500 in gift cards!

“Content creation is, in fact, their unique expertise.”-Emily S. Miller Alex Michel and Emily S. Miller share the findings of their scoping review to uncover the relationship between public health entities and social media influencers to advance public health causes. They provide practical tips on how best to foster relationships with social media influencers, and how to implement and evaluate social media influencer campaigns. This episode references the article “The Emerging Landscape of Social Media Influencers in Public Health Collaborations: A Scoping Review” by Alexandra E. Michel, Emily S. Miller, Gretchen Schulz, and Rupali J. Limaye. The Health Education Specialist Practice Analysis (HESPA) III is now live! Take the survey here: https://ow.ly/bYqz50TfuJ1.   Complete the survey and receive 2 CECH and earn eligibility to win up to $500 in gift cards!

CU Boulder Nobel Prize Winner Tom Cech discusses his new book, The Catalyst, RNA and the Quest to Unlock Life's Deepest Secrets Tom Cech is our featured interview for the KGNU Fall Membership Drive.  Thank you to listeners who are contributing funds to help our volunteer powered, noncommercial, community radio station.  If you like what … Continue reading "CU Boulder Nobel Prize Winner Tom Cech & “The Catalyst”"

“Language justice shifts the responsibility from the person to the system.” Elizabeth Jarpe-Ratner and D. Little describe the development, implementation, and evaluation of a mandatory professional development program designed for Chicago Public Schools faculty and staff which addresses gender-inclusive behaviors to support transgender, nonbinary, and gender-nonconforming (TNBGNC) students in the school district. They share recommendations which can be followed in other school districts to reduce harm, harassment, and violence affecting TNBGNC students. This episode references the article “Evaluation of a Mandatory Professional Development on Supporting Transgender, Nonbinary, and Gender-Nonconforming Students in Chicago Public Schools” by Elizabeth Jarpe-Ratner and colleagues. The Health Education Specialist Practice Analysis (HESPA) III is now live! Take the survey here: https://ow.ly/bYqz50TfuJ1. Complete the survey and receive 2 CECH and earn eligibility to win up to $500 in gift cards!

Dzisiaj moim gościem jest Jarosław Gibas - socjolog i autor książek takich jak Narcyz, Psychopata, a teraz też Manipulator. Rozmawiamy o tym czym różni się makiawielista od manipulatora? Dlaczego w tej ciemnej triadzie to właśnie Makiawielsta jest najbardziej wyrachowany i być może też niebezpieczny? Jaka jest geneza makiawelizmu i czy jest to kwestia genetyki, czy środowiska, w którym się wychowujemy? Jakie są cechy osobowości makiawelicznej? I czy jest szansę na zmianę, u kogoś kto stał się mistrzem manipulacji? Sponsorem odcinka jest Primabiotic - kod rabatowy ANIAK10% daje dodatkowe 10% zniżki

Mažoretky Kopretinky jsou velmi úspěšný sportovní team z Dobrovice. Mnoho let je vede Markéta Cinklová, která má ke sportu blízko už od malička. Její příběh, jak se dostala k mažoretkám je velmi úsměvný, ale na straně druhé ukazuje vůli, odhodlání a zápal pro věc. Povídali jsme si o sportu, zdraví a teamovém duchu, který je potřeba. www.helou.cz

“Language justice shifts the responsibility from the person to the system.” Author Maya I. Ragavan shares best practices for including people who use languages other than English in research. She highlights how language justice can be a barrier to achieving health equity and exacerbates health disparities in these populations. The six core pillars required to achieve language justice are expounded upon in this episode. This episode references the article “Applying a Language Justice Framework in Research: A Step Toward Achieving Health Equity” by Tran Doan, Gabriela Lopez-Zeron, Guillermo Prado., and Maya I. Ragavan. The Health Education Specialist Practice Analysis (HESPA) III is now live! Take the survey here: https://ow.ly/bYqz50TfuJ1.   Complete the survey and receive 2 CECH and earn eligibility to win up to $500 in gift cards!

Dr Thomas R. Cech shared the nobel prize in chemistry with Sidney Altman in 1989. Their work showed that RNA is not only a molecule that carries genetic information but can also act as a catalyst in biochemical reactions, a role that was previously thought to be exclusive to proteins. His book titled “The Catalyst: RNA and the Quest to Unlock Life's Deepest Secrets”, released in June, is a brilliant read. RNA has helped us understand the mysteries of the origins of life during the big bang and saved millions of lives by concocting life-saving vaccines during the pandemic. It does more, of course. In this podcast Tom also talks about his first lab, how he helps students to deal with failures in their experiments, how to write without using jargons and his experience of winning the Nobel Prize.

W tym odcinku omawiam jak poradzić sobie z problemami dotyczącymi ludzi w firmach. Pokazuję możliwe powody i rozwiązania.Bezpłatna konsultacjaOgłoszenia o pracęRozwiązania:Rozmowa z ludźmi i managerami - poznanie perspektywy obu stron - bardzo często odkrywa to prawdziwe problemy. Zlokalizowanie problemów z listy powyżej. Porównanie warunków do rynku, przegląd całości.Audyt zarządzania -> managerowie/dyrektorzy. Co robią, że zarządzają? https://www.youtube.com/watch?v=qZvM-5yhkFc [NSM 217: Jak budować i rozwijać zespół zarządzający? 10 problemów i wniosków] + https://www.youtube.com/watch?v=cJTlhjuzKFk [Jakie 7 CECH powinien mieć MENEDŻER PRZYSZŁOŚCI?] + https://www.youtube.com/watch?v=RCSEdrIFUOQ [S12: Co powinien robić manager sprzedaży?]Przegląd / odchudzenie / zracjonalizowanie struktury w firmie (przykład AdWise) - https://www.youtube.com/watch?v=BdiFCQ6DMDE [S06: Mapa procesów w sprzedaży i marketingu]  + https://www.youtube.com/watch?v=H0K8e_0Ny1s [S20: Struktura, role i specjalizacje w sprzedaży B2B]Rozpisanie ról, wynagrodzeń i obowiązków na nowej strukturze, - https://www.youtube.com/watch?v=4AV38G1QVDs [S21: Wynagrodzenia w sprzedaży B2B - ile płacić handlowcom?]Proces rekrutacji - zbudowanie https://www.youtube.com/watch?v=-Op7L7EShZA [S14: Jak skutecznie rekrutować i wdrażać nowe osoby w dziale sprzedaży?]Oceny kwartalne,Szkolenie feedback + feedbacki na każdym poziomie,Mądry szef HRu, - https://www.youtube.com/watch?v=YVapkHRfzuc [Jak dział HR zmienił naszą firmę? HR w biznesie. | Anna Makieła-Zoń]Przegląd modelu biznesowego i zbudowanie strategii konkurowania - https://www.youtube.com/watch?v=0We90ASxULE [Business Model Canvas w praktyce! Jak stworzyć DOCHODOWĄ FIRMĘ?] + https://www.youtube.com/watch?v=jI2NKFI0zGs [SKALOWANIE FIRMY - Jak robić to z GŁOWĄ?]Proces planów naprawczych zamiast pochopnego zwalniania https://www.youtube.com/watch?v=O87W9bC7MvE [Zbyt pochopne ZWOLNIENIE PRACOWNIKA - co możesz STRACIĆ?] + https://www.youtube.com/watch?v=rK6a60e7eH4 [Jak skutecznie przeprowadzić PLAN NAPRAWCZY Z PRACOWNIKIEM?]Posprzątanie kultury organizacyjnej - to bardzo duży temat https://www.youtube.com/watch?v=lIuAqbXArxA [NSM 223: Jak wygrywać kulturą organizacyjną? - Paweł Poniatowski / Praska - zwycięzca]Budowanie środowiska pracy, które ułatwia pracę https://www.youtube.com/watch?v=zVP4PiZUzdU [NSM 210: Handlowcy nie używają systemu CRM? 14 najczęstszych powodów]Nieprzesadzanie z budową procesów - ubezwłasnowolnienie ludzi i brak myślenia - https://www.youtube.com/watch?v=-UMvFOP1FPM [NSM 204: Procesy vs Wolność - jak błędne procesy mogą zniszczyć biznes?]Szkolenie Machina B2B 3.0 https://www.sellwise.pl/machina-30/

2 FREE MLB Picks & Predictions by Brandon Cech, Thursday 7/25/24

Poznaliśmy program tegorocznego festiwalu "Dwa Brzegi". Poza wartościami artystycznymi tegoroczna edycja przynosi także pełnoletniość temu wydarzeniu. "Dwa Brzegi" odbędą się bowiem już po raz osiemnasty. O swoich refleksjach dotyczących festiwalu i planach z nim związanych opowiedziała w Programie 2 Polskiego Radia Grażyna Torbicka - dyrektor artystyczna wydarzenia.

Wystąpienie dr. inż. Zbigniew Kuriaty, Konferencja „Dziedzictwo wsi lubuskiej i dolnośląskiej”, 16 październik 2015 [20min] https://wszechnica.org.pl/wyklad/krajobraz-i-architektura-wsi-dolnoslaskiej-i-lubuskiej/ Lubuskie i Dolnośląskie to obszar pogranicza, gdzie mieszały się wielonarodowe wpływy kulturowe. Charakterystyka architektury ludowej oraz krajobrazu tych regionów była tematem wystąpienia dr. inż. Zbigniewa Kuriaty podczas konferencji „Dziedzictwo wsi lubuskiej i dolnośląskiej – wiedza, dobre praktyki, wyzwania”. Historyczna tkanka architektoniczna w woj. dolnośląskim i lubuskim składa się przede wszystkim z obiektów murowanych. Jak przypomniał Zbigniew Kuriata, władze pruskie w l. 60 XIX w. zabroniły wznoszenie budynków drewnianych. Cechą charakterystyczną dla obu regionów jest zwarta zabudowa wsi, czym Lubuskie i Dolnośląskie wyróżniają się na tle kilku innych regionów w Polsce. Prelegent podkreślił, że istotnym elementem składającym się na krajobraz obu województw są pola uprawne z charakterystycznym układem miedz. Szczególnej troski o jego zachowanie wymagają zwłaszcza obszary górskie Dolnego Śląska. Rolnictwo schodzi bowiem z gór coraz niżej, w wyniku czego pola zarastają pozostawione same sobie. Aby przestrzeń wsi była spójna po względem formy oraz zachowała symbole będące wyrazem jej wyjątkowości, niezbędna jest – oprócz czynników instytucjonalnych, świadomość społeczna mieszkańców w zakresie posiadanego dziedzictwa kulturowego. Trzeba działać na rzecz jej podnoszenia, postulował Zbigniew Kuriata. Znajdź nas: https://www.youtube.com/c/WszechnicaFWW/ https://www.facebook.com/WszechnicaFWW1/ https://anchor.fm/wszechnicaorgpl---historia https://anchor.fm/wszechnica-fww-nauka https://wszechnica.org.pl/ #łaz #zabór #wieś #polskawieś #krajobraz #kultura #dziedzictwo #lubuskie #dziedzictwokulturowe

3 FREE MLB Picks & Predictions by Brandon Cech, Thursday 7/11/24

Erin Cech is an Associate Professor of Sociology at the University of Michigan and the author of The Trouble with Passion: How Searching for Fulfillment at Work Fosters Inequality. She studies societal inequality and cultural forces which reproduce inequality.  On this week's episode of Everyday Better, Erin and Leah discuss what can happen when we turn our passion into a career. While many people believe this is the key to that feeling of never working a day in your life, the “passion principle,” as Erin calls it, doesn't necessarily pave the way to personal fulfillment or financial stability. Instead, she argues, this advice can perpetuate socioeconomic inequality and unfair working conditions. She poses a question everyone should ask themselves when considering their career: what kind of relationship do you want to paid employment?  Follow Leah Smart on LinkedIn. Follow Erin Cech on LinkedIn. For more on the passion principle and its pitfalls, check out Erin's book The Trouble with Passion: How Searching for Fulfillment at Work Fosters Inequality. And don't forget to sign up for Leah's weekly newsletter to get practical tips on how to level up with small steps every day.

3 FREE MLB Picks & Predictions by Brandon Cech, Thursday 6/27/24

Naše prostředí nás velmi ovlivňuje. Je proto důležité si uvědomovat, jestli je nám v něm dobře. Pak jsme totiž i aktivnější v tom věci kolem nás měnit. „Najít krásu v tom, co už tu je,“ to doporučuje Pavla Melková ve Vizitce. S Karolínou Koubovou mluví také o tom, jak vzniká její poezie, co má společného s architekturou nebo čím ji okouzluje Japonsko.Všechny díly podcastu Vizitka můžete pohodlně poslouchat v mobilní aplikaci mujRozhlas pro Android a iOS nebo na webu mujRozhlas.cz.

Naše prostředí nás velmi ovlivňuje. Je proto důležité si uvědomovat, jestli je nám v něm dobře. Pak jsme totiž i aktivnější v tom věci kolem nás měnit. „Najít krásu v tom, co už tu je,“ to doporučuje Pavla Melková ve Vizitce. S Karolínou Koubovou mluví také o tom, jak vzniká její poezie, co má společného s architekturou nebo čím ji okouzluje Japonsko.

W lipcu w Krośnie startuje 9. edycja Young Arts Festivalu. O tym wydarzeniu opowiedział w audycji "Wybieram Dwójkę" Bartłomiej Tełewiak - kameralista i solista, koncertmistrz orkiestry Filharmonii Dolnośląskiej oraz dyrektor festiwalu. Artysta zdradził m.in. dlaczego w tym roku impreza potrwa cztery dni oraz jak na organizację festiwalu wpłynął fakt, że wydarzenie odbędzie się w hangarze lotniczym. 

In this episode, Xavier Bonilla has a dialogue with Thomas Cech about RNA as a major catalyst in organic systems. They discuss why RNA does not get discussed as much as DNA, basics of DNA, RNA as a catalyst, and the splicing capabilities of RNA. They also talk about transcription, translation, and splicing, RNA as internal catalyst and external catalyst, and the origins of life. They talk about telomeres and extended life, different types of RNA, mRNA vaccines, CRISPR, and many more topics. Thomas Cech is distinguished professor of chemistry and biochemistry at the University of Colorado-Boulder. He has been an Investigator at the Howard Hughes Medical Institute (HHMI) since 1988 and was President of HHMI in 2000-2009. He has his PhD from the University of California-Berkeley and completed his postdoctorate at MIT. His main interests are in RNA and telomeres. He received the Nobel Prize in Chemistry (with Sidney Altman) in 1989 and the National Medal of Science in 1995. He is the author of the latest book, The Catalyst: RNA and the Quest to Unlock Life's Deepest Secrets. Get full access to Converging Dialogues at convergingdialogues.substack.com/subscribe

Americānī in Sīnīs vulnerātī Quattuor Americānī, quī in parvā studiōrum ūniversitāte in Īovā cīvitāte sitā docent, in Jilin regiōne Sīnārum, dum templum quoddam vīsunt, ā vīrō quōdam quīnquāginta et quinque annōs nātō, ob causam ignōtam, sunt cultrō laesī. Nēmō vidētur graviter esse vulnerātus. Malaviēnsium vice-praeses periit Saulus Chilīma, vice-praeses Malaviēnsium, et nōvem aliī periērunt, cum āeroplānum, quō veherentur, subitō dē caelō in montibus dēlapsum esset. Chilīma modo diē Sōlis reversus est ē Cōrēā Merīdiōnālī. Comitia Eurōpæa Suffrāgiīs per tōtam ūniōnem Eurōpaeam ad novōs senātōrēs Eurōpaeōs ēligendōs lātīs, factiōnēs dextrae victōrēs ēvāsērunt et aliās, quae in Galliā et Germaniā pollent, facile superāvērunt. Maximum enim damnum illātum est in factiōnem Eurōpae Renovandae quae sociāta est cum Emmanuēle Macron praeside Gallōrum, sed etiam clādem tulit factio Viridis. Inter factiōnēs, quārum auctōritas crēvit, numerantur factiō Eurōpaeī Populī, quae favet Ursulae von der Leyen, et factiō Identitātis et Populāris Cīvitātis. Senātus Eurōpaeus numquam anteā erat tantōpere ad dextrās partēs īnclinātus. Comitia in Gallia indicta Sōlis diē Emmanuēl Macron, praeses Gallōrum, senātum dīmīsit et nova comitia indīxit, cum in comitiīs Europaeīs dextrae partēs factionem suam superāvisse vidērentur. Factiō, ad quam Macron ipse pertinet, nē sextam quidem partem suffragiōrum potuit ferre. Factiō Repūblicānōrum coepit dīcere sē velle cum factiōne dextrā, Restitūtiōne Nātiōnālī, sociārī, quod annīs priōribus prohibitum erat eō cōnsēnsū factiōnum, quī “chorda sānitātis” vocābātur. Magistrātūs Candidātīque oppugnātī Mette Frederiksen, ministra prīmāria Dānōrum, nōn malē sē habet postquam vir quīdam eam Havniae verberāvit. Vir fertur Polōnus fuisse, ūndēquadrāginta annōs nātus et temētō medicāmentīsque inēbriātus. Item in Britanniā Nigellus Farage, quī factiōnī Reformātiōnem prōmōventī praeest, bis oppugnātus est, prīmum ā fēmina quae pōtiōnem in suam faciem comminus iēcit, deinde ab homine quī lapidēs quōsdam in eum iēcit. Farage prō suā parte dīxit sē nōn posse ā vītā pūblicā vī dēterrērī. Operāriī Omnium Gentium comprehēnsī Iementītae Houthiānī, quī in magistrātūs bellum cīvīle gerunt, ūndecim operāriōs Coetūs Omnium Gentium necnōn aliōs comprehendērunt quī cōnābantur auxilium Iemenītīs afferre et iūra hūmāna prōmōvēre, quōs Houthiānī dīcunt speculātōrēs fuisse opera clandestīna prō Americānīs Isrāēlītīsque suscipientēs. Ingvārus Gorgan in iūs vocandus Ingvārus Gorgan, quī praefectus erat mīlitum Moldovānōrum, et ordine et honōribus diē Mercuriī prīvātus est, ut quī putārētur documenta arcāna speculātōribus Russicīs ab annō bis millēsimō secundō dedisse. Vērisīmile vidētur Ingvārum in iūs vocātum īrī crīmine māiestātis. Speculātrix Russica comprehēnsa Magistrātūs Dānī diē Martis nūntiāvērunt fēminam Russicam esse comprehēnsam, quippe quae pecūniam accēpisset ā Pravfond, cōpiā Russicā quae cūrat falsōs nuntiōs extrā Russiam dīvulgandōs. Mēnsibus recentioribus hominēs in Germāniā, Austriā, Polōniā, Estōniā sunt ob suspiciōnem prō Russīs speculandī comprehēnsī. Lēgātus autem Russōrum in Dānōs missus, Vladimirus Barbin nōmine, dīxit speculātōrēs Dānōrum cōnārī Russōs prōvocāre. Cechī Russōs habent suspectōs Magistrātūs Cechī virum quendam ex Americā Merīdiānā oriundum dēprehendērunt, quī cōnātus est raedas longās et pūblicās combūrere. Suspicantur porrō impetum excogitātum esse ā Russīs, quī et suīs opibus facinus fōverint. Russī ipsī negant sē reī immixtōs esse. Mēnse priōre, Pōlōnī magistrātūs ūnum Pōlōnum et duō Bielorussōs comprehendērunt quōs suspectōs in incendiīs malō dolō factīs habērent. Minister Brasiliānus corruptiōnis accūsātus Custōdēs pūblicī Brasiliānī accūsāvērunt Ioscelīnum Filho, ministrum rērum divulgandārum, et pecūniae acceptae et pecūniae “lautae” (id est, ita occultātae nē quis originem suspicārētur) et cōnsociātiōnis ad lēgēs violandās. Filho ipse negat sē quidquam malī fēcisse, dīcēns accūsātiōnem factam esse propter invidiam politicam. Filho annō priōre in īnfāmiam inciderat cum mīlitārī aeroplānō vectus esset ut auctiōnī equōrum adesset. Taurus In Oregōniae cīvitātis urbe Sorōrum, taurus ex arēnā in spectātōrēs exsiluit et per tabernās in āream stātīvam fūgit, hominēs quibus obviam vēnit vulnerāns. Quattuor enim hominēs referuntur esse vulnerātī. Nam in plērīsque cīvitātibus occidentālibus et Americānīs armentāriī aliīque rusticī coram spectātōribus solent in arēnam cum taurīs dēscendere nōn ideō, ut Hispānōrum mōre eōs interficiant, sed ut iīs quamvīs ferīs vehantur potius vel eōs fūnibus doment necnōn etiam cum iīs luctentur. Quibus autem in lūdīs bucolicīs spectātōrēs rārō in perīculum veniunt. Astronauta diem obiit Villelmus Anders, praefectus mājor mīlitum āeriōrum et astronauta quī annō millēsimō nōningentēsimō duodēseptuāgēsimō notissimam imāginem tellūris supra lūnam orientis dēscrīpserat, diē Veneris, cum aeroplānum sōlus gubernāret dē caelō dēlapsus est in mare prope īnsulam Jones dictam, nōn longē ā Bellinghāmiā. Vīxit annōs nōnāgintā.

In this podcast, Thomas Czech, Distinguished Professor at the University of Colorado, Boulder, with a lineage of remarkable contributions on RNA, ribozyme, and telomeres, discuss why RNA is so incredibly versatile.Video snippet from our conversation. Full videos of all Ground Truths podcasts can be seen on YouTube here. The audios are also available on Apple and Spotify.Transcript with links to the audio and external linksEric Topol (00:07):Well, hello, this is Eric Topol from Ground Truths, and it's really a delight for me to welcome Tom Cech who just wrote a book, the Catalyst, and who is a Nobel laureate for his work in RNA. And is at the University of Colorado Boulder as an extraordinary chemist and welcome Tom.Tom Cech (00:32):Eric, I'm really pleased to be here.The RNA GuyEric Topol (00:35):Well, I just thoroughly enjoyed your book, and I wanted to start out, if I could, with a quote, which gets us right off the story here, and let me just get to it here. You say, “the DNA guy would need to become an RNA guy. Though I didn't realize it at the time, jumping ship would turn out to be the most momentous decision in my life.” Can you elaborate a bit on that?Tom Cech (01:09):As a graduate student at Berkeley, I was studying DNA and chromosomes. I thought that DNA was king and really somewhat belittled the people in the lab next door who were working on RNA, I thought it was real sort of second fiddle material. Of course, when RNA is acting just as a message, which is an important function, a critical function in all life on earth, but still, it's a function that's subservient to DNA. It's just copying the message that's already written in the playbook of DNA. But little did I know that the wonders of RNA were going to excite me and really the whole world in unimaginable ways.Eric Topol (02:00):Well, they sure have, and you've lit up the world well before you had your Nobel Prize in 1989 was Sid Altman with ribozyme. And I think one of the things that struck me, which are so compelling in the book as I think people might know, it's divided in two sections. The first is much more on the biology, and the second is much more on the applications and how it's changing the world. We'll get into it particularly in medicine, but the interesting differentiation from DNA, which is the one trick pony, as you said, all it does is store stuff. And then the incredible versatility of RNA as you discovered as a catalyst, that challenging dogma, that proteins are supposed to be the only enzymes. And here you found RNA was one, but also so much more with respect to genome editing and what we're going to get into here. So I thought what we might get into is the fact that you kind of went into the scum of the pond with this organism, which by the way, you make a great case for the importance of basic science towards the end of the book. But can you tell us about how you, and then of course, many others got into the Tetrahymena thermophila, which I don't know that much about that organism.Tom Cech (03:34):Yeah, it's related to Tetrahymena is related to paramecium, which is probably more commonly known because it's an even larger single celled animal. And therefore, in an inexpensive grade school microscope, kids can look through and see these ciliated protozoa swimming around on a glass slide. But I first learned about them when I was a postdoc at MIT and I would drive down to Joe Gall's lab at Yale University where Liz Blackburn was a postdoc at the time, and they were all studying Tetrahymena. It has the remarkable feature that it has 10,000 identical copies of a particular gene and for a higher organism, one that has its DNA in the nucleus and does its protein synthesis in the cytoplasm. Typically, each gene's present in two copies, one from mom, one from dad. And if you're a biochemist, which I am having lots of stuff is a real advantage. So 10,000 copies of a particular gene pumping out RNA copies all the time was a huge experimental advantage. And that's what I started working on when I started my own lab at Boulder.Eric Topol (04:59):Well, and that's where, I guess the title of the book, the Catalyst ultimately, that grew into your discovery, right?Tom Cech (05:08):Well, at one level, yes, but I also think that the catalyst in a more general conversational sense means just facilitating life in this case. So RNA does much more than just serve as a biocatalyst or a message, and we'll get into that with genome editing and with telomerase as well.The Big Bang and 11 Nobel Prizes on RNA since 2000Eric Topol (05:32):Yes, and I should note that as you did early in the book, that there's been an 11 Nobel prize awardees since 2000 for RNA work. And in fact, we just had Venki who I know you know very well as our last podcast. And prior to that, Kati Karikó, Jennifer Doudna who worked in your lab, and the long list of people working RNA in the younger crowd like David Liu and Fyodor Urnov and just so many others, we need to have an RNA series because it's just exploding. And that one makes me take you back for a moment to 2007. And when I was reading the book, it came back to me about the Economist cover. You may recall almost exactly 17 years ago. It was called the Biology's Big Bang – Unravelling the secrets of RNA. And in that, there was a notable quote from that article. Let me just get to that. And it says, “it is probably no exaggeration to say that biology is now undergoing its neutron moment.”(06:52):This is 17 years ago. “For more than half a century the fundamental story of living things has been a tale of the interplay between genes, in the form of DNA, and proteins, which is genes encode and which do the donkey work of keeping living organisms living. The past couple of years, 17 years ago, however, has seen the rise and rise of a third type of molecule, called RNA.” Okay, so that was 2007. It's pretty extraordinary. And now of course we're talking about the century of biology. So can you kind of put these last 17 years in perspective and where we're headed?Tom Cech (07:34):Well, Eric, of course, this didn't all happen in one moment. It wasn't just one big bang. And the scientific community has been really entranced with the wonders of RNA since the 1960s when everyone was trying to figure out how messenger RNA stored the genetic code. But the general public has been really kept in the dark about this, I think. And as scientists, were partially to blame for not reaching out and sharing what we have found with them in a way that's more understandable. The DNA, the general public's very comfortable with, it's the stuff of our heredity. We know about genetic diseases, about tracing our ancestry, about solving crimes with DNA evidence. We even say things like it's in my DNA to mean that it's really fundamental to us. But I think that RNA has been sort of kept in the closet, and now with the mRNA vaccines against Covid-19, at least everyone's heard of RNA. And I think that that sort of allowed me to put my foot in the door and say, hey, if you were curious about the mRNA vaccines, I have some more stories for you that you might be really interested in.RNA vs RNAEric Topol (09:02):Yeah, well, we'll get to that. Maybe we should get to that now because it is so striking the RNA versus RNA chapter in your book, and basically the story of how this RNA virus SARS-CoV-2 led to a pandemic and it was fought largely through the first at scale mRNA nanoparticle vaccine package. Now, that takes us back to some seminal work of being able to find, giving an mRNA to a person without inciting massive amount of inflammation and the substitution of pseudouridine or uridine in order to do that. Does that really get rid of all the inflammation? Because obviously, as you know, there's been some negativism about mRNA vaccines for that and also for the potential of not having as much immune cell long term activation. Maybe you could speak to that.Tom Cech (10:03):Sure. So the discovery by Kati Karikó and Drew Weissman of the pseudouridine substitution certainly went a long way towards damping down the immune response, the inflammatory response that one naturally gets with an RNA injection. And the reason for that is that our bodies are tuned to be on the lookout for foreign RNA because so many viruses don't even mess with DNA at all. They just have a genome made of RNA. And so, RNA replicating itself is a danger sign. It means that our immune system should be on the lookout for this. And so, in the case of the vaccination, it's really very useful to dampen this down. A lot of people thought that this might make the mRNA vaccines strange or foreign or sort of a drug rather than a natural substance. But in fact, modified nucleotides, nucleotides being the building blocks of RNA, so these modified building blocks such as pseudoU, are in fact found in natural RNAs more in some than in others. And there are about 200 modified versions of the RNA building blocks found in cells. So it's really not an unusual modification or something that's all that foreign, but it was very useful for the vaccines. Now your other question Eric had to do with the, what was your other question, Eric?Eric Topol (11:51):No, when you use mRNA, which is such an extraordinary way to get the spike protein in a controlled way, exposed without the virus to people, and it saved millions of lives throughout the pandemic. But the other question is compared to other vaccine constructs, there's a question of does it give us long term protective immunity, particularly with T cells, both CD8 cytotoxic, maybe also CD4, as I know immunology is not your main area of interest, but that's been a rub that's been put out there, that it isn't just a weaning of immunity from the virus, but also perhaps that the vaccines themselves are not as good for that purpose. Any thoughts on that?Tom Cech (12:43):Well, so my main thought on that is that this is a property of the virus more than of the vaccine. And respiratory viruses are notoriously hard to get long-term immunity. I mean, look at the flu virus. We have to have annual flu shots. If this were like measles, which is a very different kind of virus, one flu shot would protect you against at least that strain of flu for the rest of your life. So I think the bad rap here is not the vaccine's fault nearly as much as it's the nature of respiratory viruses.RNA And Aging Eric Topol (13:27):No, that's extremely helpful. Now, let me switch to an area that's really fascinating, and you've worked quite a bit on the telomerase story because this is, as you know, being pursued quite a bit, has thought, not just because telomeres might indicate something about biologic aging, but maybe they could help us get to an anti-aging remedy or whatever you want to call it. I'm not sure if you call it a treatment, but tell us about this important enzyme, the role of the RNA building telomeres. And maybe you could also connect that with what a lot of people might not be familiar with, at least from years ago when they learned about it, the Hayflick limit.Tom Cech (14:22):Yes. Well, Liz Blackburn and Carol Greider got the Nobel Prize for the discovery of telomerase along with Jack Szostak who did important initial work on that system. And what it does is, is it uses an RNA as a template to extend the ends of human chromosomes, and this allows the cell to keep dividing without end. It gives the cell immortality. Now, when I say immortality, people get very excited, but I'm talking about immortality at the cellular level, not for the whole organism. And in the absence of a mechanism to build out the ends of our chromosomes, the telomeres being the end of the chromosome are incompletely replicated with each cell division. And so, they shrink over time, and when they get critically short, they signal the cell to stop dividing. This is what is called the Hayflick limit, first discovered by Leonard Hayflick in Philadelphia.(15:43):And he, through his careful observations on cells, growing human cells growing in Petri dishes, saw that they could divide about 50 times and then they wouldn't die. They would just enter a state called senescence. They would change shape, they would change their metabolism, but they would importantly quit dividing. And so, we now see this as a useful feature of human biology that this protects us from getting cancer because one of the hallmarks of cancer is immortality of the tumor cells. And so, if you're wishing for your telomeres to be long and your cells to keep dividing, you have to a little bit be careful what you wish for because this is one foot in the door for cancer formation.Eric Topol (16:45):Yeah, I mean, the point is that it seems like the body and the cell is smart to put these cells into the senescent state so they can't divide anymore. And one of the points you made in the book that I think is worth noting is that 90% of cancers have the telomerase, how do you say it?Tom Cech (17:07):Telomerase.Eric Topol (17:08):Yeah, reactivate.Tom Cech (17:09):Right.Eric Topol (17:10):That's not a good sign.Tom Cech (17:12):Right. And there are efforts to try to target telomerase enzyme for therapeutic purposes, although again, it's tricky because we do have stem cells in our bodies, which are the exception to the Hayflick limit rule. They do still have telomerase, they still have to keep dividing, maybe not as rapidly as a cancer cell, but they still keep dividing. And this is critical for the replenishment of certain worn out tissues in our such as skin cells, such as many of our blood cells, which may live only 30 days before they poop out. That's a scientific term for needing to be replenished, right?Eric Topol (18:07):Yeah. Well, that gets me to the everybody's, now I got the buzz about anti-aging, and whether it's senolytics to get rid of these senescent cells or whether it's to rejuvenate the stem cells that are exhausted or work on telomeres, all of these seem to connect with a potential or higher risk of cancer. I wonder what your thoughts are as we go forward using these various biologic constructs to be able to influence the whole organism, the whole human body aging process.Tom Cech (18:47):Yes. My view, and others may disagree is that aging is not an affliction. It's not a disease. It's not something that we should try to cure, but what we should work on is having a healthy life into our senior years. And perhaps you and I are two examples of people who are at that stage of our life. And what we would really like is to achieve, is to be able to be active and useful to society and to our families for a long period of time. So using the information about telomerase, for example, to help our stem cells stay healthy until we are, until we're ready to cash it in. And for that matter on the other side of the coin, to try to inhibit the telomerase in cancer because cancer, as we all know, is a disease of aging, right? There are young people who get cancer, but if you look at the statistics, it's really heavily weighted towards people who've been around a long time because mutations accumulate and other damage to cells that would normally protect against cancer accumulates. And so, we have to target both the degradation of our stem cells, but also the occurrence of cancer, particularly in the more senior population. And knowing more about RNA is really helpful in that regard.RNA DrugsEric Topol (20:29):Yeah. Well, one of the things that comes across throughout the book is versatility of RNA. In fact, you only I think, mentioned somewhere around 12 or 14 of these different RNAs that have a million different shapes, and there's so many other names of different types of RNAs. It's really quite extraordinary. But one of the big classes of RNAs has really hit it. In fact, this week there are two new interfering RNAs that are having extraordinary effects reported in the New England Journal on all the lipids, abnormal triglycerides and LDL cholesterol, APOC3. And can you talk to us about this interfering the small interfering RNAs and how they become, you've mentioned in the book over 400 RNAs are in the clinic now.Tom Cech (21:21):Yeah, so the 400 of course is beyond just the siRNAs, but these, again, a wonderful story about how fundamental science done just to understand how nature works without any particular expectation of a medical spinoff, often can have the most phenomenal and transformative effects on medicine. And this is one of those examples. It came from a roundworm, which is about the size of an eyelash, which a scientist named Sydney Brenner in England had suggested would be a great experimental organism because the entire animal has only about a thousand cells, and it's transparent so we can look at, see where the cells are, we can watch the worm develop. And what Andy Fire and Craig Mello found in this experimental worm was that double-stranded RNA, you think about DNA is being double-stranded and RNA as being single stranded. But in this case, it was an unusual case where the RNA was forming a double helix, and these little pieces of double helical RNA could turn off the expression of genes in the worm.(22:54):And that seemed remarkable and powerful. But as often happens in biology, at least for those of us who believe in evolution, what goes for the worm goes for the human as well. So a number of scientists quickly found that the same process was going on in the human body as a natural way of regulating the expression of our genes, which means how much of a particular gene product is actually going to be made in a particular cell. But not only was it a natural process, but you could introduce chemically synthesized double helical RNAs. There are only 23 base pairs, 23 units of RNA long, so they're pretty easy to chemically synthesize. And that once these are introduced into a human, the machinery that's already there grabs hold of them and can be used to turn off the expression of a disease causing RNA or the gene makes a messenger RNA, and then this double-stranded RNA can suppress its action. So this has become the main company that is known for doing this is Alnylam in Boston, Cambridge. And they have made quite a few successful products based on this technology.Eric Topol (24:33):Oh, absolutely. Not just for amyloidosis, but as I mentioned these, they even have a drug that's being tested now, as you know that you could take once or twice a year to manage your blood pressure. Wouldn't that be something instead of a pill every day? And then of course, all these others that are not just from Alnylam, but other companies I wasn't even familiar with for managing lipids, which is taking us well beyond statins and these, so-called PCSK9 monoclonal antibodies, so it's really blossoming. Now, the other group of RNA drugs are antisense drugs, and it seemed like they took forever to warm up, and then finally they hit. And can you distinguish the antisense versus the siRNA therapeutics?Tom Cech (25:21):Yes, in a real general sense, there's some similarity as well as some differences, but the antisense, what are called oligonucleotides, whoa, that's a big word, but oligo just means a few, right? And nucleotides is just the building blocks of nucleic acid. So you have a string of a few of these. And again, it's the power of RNA that it is so good at specifically base pairing only with matching sequences. So if you want to match with a G in a target messenger RNA, you put a C in the antisense because G pairs with C, if you want to put an A, if want to match with an A, you put a U in the antisense because A and U form a base pair U is the RNA equivalent of T and DNA, but they have the same coding capacity. So any school kid can write out on a notepad or on their laptop what the sequence would have to be of an antisense RNA to specifically pair with a particular mRNA.(26:43):And this has been, there's a company in your neck of the woods in the San Diego area. It started out with the name Isis that turned out to be the wrong Egyptian God to name your company after, so they're now known as Ionis. Hopefully that name will be around for a while. But they've been very successful in modifying these antisense RNAs or nucleic acids so that they are stable in the body long enough so that they can pair with and thereby inhibit the expression of particular target RNAs. So it has both similarities and differences from the siRNAs, but the common denominator is RNA is great stuff.RNA and Genome EditingEric Topol (27:39):Well, you have taken that to in catalyst, the catalyst, you've proven that without a doubt and you and so many other extraordinary scientists over the years, cumulatively. Now, another way to interfere with genes is editing. And of course, you have a whole chapter devoted to not just well CRISPR, but the whole genome editing field. And by the way, I should note that I forgot because I had read the Codebreaker and we recently spoke Jennifer Doudna and I, that she was in your lab as a postdoc and you made some wonderful comments about her. I don't know if you want to reflect about having Jennifer, did you know that she was going to do some great things in her career?Tom Cech (28:24):Oh, there was no question about it, Eric. She had been a star graduate student at Harvard, had published a series of breathtaking papers in magazines such as Science and Nature already as a graduate student. She won a Markey fellowship to come to Colorado. She chose a very ambitious project trying to determine the molecular structures of folded RNA molecules. We only had one example at the time, and that was the transfer RNA, which is involved in protein synthesis. And here she was trying these catalytic RNAs, which we had discovered, which were much larger than tRNA and was making great progress, which she finished off as an assistant professor at Yale. So what the general public may not know was that in scientific, in the scientific realm, she was already highly appreciated and much awarded before she even heard anything about CRISPR.Eric Topol (29:38):Right. No, it was a great line you have describing her, “she had an uncanny talent for designing just the right experiment to test any hypothesis, and she possessed more energy and drive than any scientist I'd ever met.” That's pretty powerful. Now getting into CRISPR, the one thing, it's amazing in just a decade to see basically the discovery of this natural system to then be approved by FDA for sickle cell disease and beta thalassemia. However, the way it exists today, it's very primitive. It's not actually fixing the gene that's responsible, it's doing a workaround plan. It's got double strand breaks in the DNA. And obviously there's better ways of editing, which are going to obviously involve RNA epigenetic editing, if you will as well. What is your sense about the future of genome editing?Tom Cech (30:36):Yeah, absolutely, Eric. It is primitive right now. These initial therapies are way too expensive as well to make them broadly applicable to the entire, even in a relatively wealthy country like the United States, we need to drive the cost down. We need to get them to work, we need to get the process of introducing them into the CRISPR machinery into the human body to be less tedious and less time consuming. But you've got to start somewhere. And considering that the Charpentier and Doudna Nobel Prize winning discovery was in 2012, which is only a dozen years ago, this is remarkable progress. More typically, it takes 30 years from a basic science discovery to get a medical product with about a 1% chance of it ever happening. And so, this is clearly a robust RNA driven machine. And so, I think the future is bright. We can talk about that some more, but I don't want to leave RNA out of this conversation, Eric. So what's cool about CRISPR is its incredible specificity. Think of the human genome as a million pages of text file on your computer, a million page PDF, and now CRISPR can find one sentence out of that million pages that matches, and that's because it's using RNA, again, the power of RNA to form AU and GC base pairs to locate just one site in our whole DNA, sit down there and direct this Cas9 enzyme to cut the DNA at that site and start the repair process that actually does the gene editing.Eric Topol (32:41):Yeah, it's pretty remarkable. And the fact that it can be so precise and it's going to get even more precise over time in terms of the repair efforts that are needed to get it back to an ideal state. Now, the other thing I wanted to get into with you a bit is on the ribosome, because that applies to antibiotics and as you call it, the mothership. And I love this metaphor that you had about the ribosome, and in the book, “the ribosome is your turntable, the mRNA is the vinyl LP record, and the protein is the music you hear when you lower the needle.” Tell us more about the ribosome and the role of antibiotics.Tom Cech (33:35):So do you think today's young people will understand that metaphor?Eric Topol (33:40):Oh, they probably will. They're making a comeback. These records are making a comeback.Tom Cech (33:44):Okay. Yes, so this is a good analogy in that the ribosome is so versatile it's able to play any music that you feed at the right messenger RNA to make the music being the protein. So you can have in the human body, we have tens of thousands of different messenger RNAs. Each one threads through the same ribosome and spills out the production of whatever protein matches that mRNA. And so that's pretty remarkable. And what Harry Noller at UC Santa Cruz and later the crystallographers Venki Ramakrishnan, Tom Steitz, Ada Yonath proved really through their studies was that this is an RNA machine. It was hard to figure that out because the ribosome has three RNAs and it has dozens of proteins as well. So for a long time people thought it must be one of those proteins that was the heart and soul of the record player, so to speak.RNA and Antibiotics(34:57):And it turned out that it was the RNA. And so, when therefore these scientists, including Venki who you just talked to, looked at where these antibiotics docked on the ribosome, they found that they were blocking the key functional parts of the RNA. So it was really, the antibiotics knew what they were doing long before we knew what they were doing. They were talking to and obstructing the action of the ribosomal RNA. Why is this a good thing for us? Because bacterial ribosomes are just enough different from human ribosomes that there are drugs that will dock to the bacterial ribosomal RNA, throw a monkey wrench into the machine, prevent it from working, but the human ribosomes go on pretty much unfazed.Eric Topol (36:00):Yeah, no, the backbone of our antibiotics relies on this. So I think people need to understand about the two subunits, the large and the small and this mothership, and you illuminate that so really well in the book. That also brings me to phage bacteria phage, and we haven't seen that really enter the clinic in a significant way, but there seems to be a great opportunity. What's your view about that?Tom Cech (36:30):This is an idea that goes way back because since bacteria have their own viruses which do not infect human cells, why not repurpose those into little therapeutic entities that could kill, for example, what would we want to kill? Well, maybe tuberculosis has been very resistant to drugs, right? There are drug resistant strains of TB, yes, of TB, tuberculosis, and especially in immunocompromised individuals, this bug runs rampant. And so, I don't know the status of that. It's been challenging, and this is the way that biomedicine works, is that for every 10 good ideas, and I would say phage therapy for bacterial disease is a good idea. For every 10 such ideas, one of them ends up being practical. And the other nine, maybe somebody else will come along and find a way to make it work, but it hasn't been a big breakthrough yet.RNA, Aptamers and ProteinsEric Topol (37:54):Yeah, no, it's really interesting. And we'll see. It may still be in store. What about aptamers? Tell us a little bit more about those, because they have been getting used a lot in sorting out the important plasma proteins as therapies. What are aptamers and what do you see as the future in that regard?Tom Cech (38:17):Right. Well, in fact, aptamers are a big deal in Boulder because Larry Gold in town was one of the discoverers has a company making aptamers to recognize proteins. Jack Szostak now at University of Chicago has played a big role. And also at your own institution, Jerry Joyce, your president is a big aptamer guy. And you can evolution, normally we think about it as happening out in the environment, but it turns out you can also make it work in the laboratory. You can make it work much faster in the laboratory because you can set up test tube experiments where molecules are being challenged to perform a particular task, like for example, binding to a protein to inactivate it. And if you make a large community of RNA molecules randomly, 99.999% of them aren't going to know how to do this. What are the odds? Very low.(39:30):But just by luck, there will be an occasional molecule of RNA that folds up into a shape that actually fits into the proteins active sighting throws a monkey wrench into the works. Okay, so now that's one in a billion. How are you going to find that guy? Well, this is where the polymerase chain reaction, the same one we use for the COVID-19 tests for infection comes into play. Because if you can now isolate this needle in a haystack and use PCR to amplify it and make a whole handful of it, now you've got a whole handful of molecules which are much better at binding this protein than the starting molecule. And now you can go through this cycle several times to enrich for these, maybe mutagen it a little bit more to give it a little more diversity. We all know diversity is good, so you put a little more diversity into the population and now you find some guy that's really good at recognizing some disease causing protein. So this is the, so-called aptamer story, and they have been used therapeutically with some success, but diagnostically certainly they are extremely useful. And it's another area where we've had success and the future could hold even more success.Eric Topol (41:06):I think what you're bringing up is so important because the ability to screen that tens of thousands of plasma proteins in a person and coming up with as Tony Wyss-Coray did with the organ clocks, and this is using the SomaLogic technology, and so much is going on now to get us not just the polygenic risk scores, but also these proteomic scores to compliment that at our orthogonal, if you will, to understand risk of people for diseases so we can prevent them, which is fulfilling a dream we've never actually achieved so far.Tom Cech (41:44):Eric, just for full disclosure, I'm on the scientific advisory board of SomaLogic in Boulder. I should disclose that.Eric Topol (41:50):Well, that was smart. They needed to have you, so thank you for mentioning that. Now, before I wrap up, well, another area that is a favorite of mine is citizen science. And you mentioned in the book a project because the million shapes of RNA and how it can fold with all hairpin terms turns and double stranded and whatever you name it, that there was this project eteRNA that was using citizen scientists to characterize and understand folding of RNA. Can you tell us about that?RNA Folding and Citizen ScienceTom Cech (42:27):So my friend Rhiju Das, who's a professor at Stanford University, sort of adopted what had been done with protein folding by one of his former mentors, David Baker in Seattle, and had repurposed this for RNA folding. So the idea is to come up with a goal, a target for the community. Can you design an RNA that will fold up to look like a four pointed cross or a five pointed star? And it turned out that, so they made it into a contest and they had tens of thousands of people playing these games and coming up with some remarkable solutions. But then they got a little bit more practical, said, okay, that was fun, but can we have the community design something like a mRNA for the SARS-CoV-2 spike protein to make maybe a more stable vaccine? And quite remarkably, the community of many of whom are just gamers who really don't know much about what RNA does, were able to find some solutions. They weren't enormous breakthroughs, but they got a several fold, several hundred percent increase in stability of the RNA by making it fold more tightly. So I just find it to be a fascinating approach to science. Somebody of my generation would never think of this, but I think for today's generation, it's great when citizens can become involved in research at that level.Eric Topol (44:19):Oh, I think it's extraordinary. And of course, there are other projects folded and others that have exemplified this ability for people with no background in science to contribute in a meaningful way, and they really enjoy, it's like solving a puzzle. The last point is kind of the beginning, the origin of life, and you make a pretty strong case, Tom, that it was RNA. You don't say it definitively, but maybe you can say it here.RNA and the Origin of LifeTom Cech (44:50):Well, Eric, the origin of life happening almost 4 billion years ago on our primitive planet is sort of a historical question. I mean, if you really want to know what happened then, well, we don't have any video surveillance of those moments. So scientists hate to ever say never, but it's hard to sort of believe how we would ever know for sure. So what Leslie Orgel at the Salk Institute next to you taught me when I was a starting assistant professor is even though we'll never know for sure, if we can recapitulate in the laboratory plausible events that could have happened, and if they make sense chemically and biologically, then that's pretty satisfying, even if we can never be absolutely sure. That's what a number of scientists have done in this field is to show that RNA is sort of a, that all the chemistry sort of points to RNA as being something that could have been made under prebiotic conditions and could have folded up into a way that could solve the greatest of all chicken and egg problems, which came first, the informational molecule to pass down to the next generation or the active molecule that could copy that information.(46:32):So now that we know that RNA has both of those abilities, maybe at the beginning there was just this RNA world RNA copying itself, and then proteins came along later, and then DNA probably much more recently as a useful but a little bit boring of genetic information, right?Eric Topol (46:59):Yeah. Well, that goes back to that cover of the Economist 17 years ago, the Big Bang, and you got me convinced that this is a pretty strong story and candidate. Now what a fun chance to discuss all this with you in an extraordinary book, Tom. Did I miss anything that you want to bring up?Tom Cech (47:21):Eric, I just wanted to say that I not only appreciate our conversation, but I also appreciate all you are doing to bring science to the non-scientist public. I think people like me who have taught a lot of freshmen in chemistry, general chemistry, sort of think that that's the level that we need to aim at. But I think that those kids have had science in high school year after year. We need to aim at the parents of those college freshmen who are intelligent, who are intellectually curious, but have not had science courses in a long time. And so, I'm really joining with you in trying to avoid jargon as much as possible. Use simple language, use analogies and metaphors, and try to share the excitement of what we're doing in the laboratory with the populace.Eric Topol (48:25):Well, you sure did that it was palpable. And I thought about it when I read the book about how lucky it would be to be a freshman at the University of Boulder and be having you as the professor. My goodness. Well, thank you so much. This has been so much fun, Tom, and I hope everybody's going to get out there and read the Catalyst to get all the things that we didn't even get a chance to dive into. But this has been great and look forward to future interactions with you.Tom Cech (48:53):Take care, Eric.*********************Thanks for listening or reading this edition of Ground Truths.Please share this podcast with your friends and network. That tells me you found it informative and makes the effort in doing these worthwhile.All Ground Truths newsletters and podcast are free. Voluntary paid subscriptions all go to support Scripps Research. Many thanks for that—they greatly helped fund our summer internship programs for 2023 and 2024.Thanks to my producer Jessica Nguyen and Sinjun Balabanoff for audio and video support at Scripps Research.Note: you can select preferences to receive emails about newsletters, podcasts, or all I don't want to bother you with an email for content that you're not interested in. Get full access to Ground Truths at erictopol.substack.com/subscribe

3 FREE MLB Picks & Predictions by Brandon Cech, Wednesday 6/5/24

Join my mailing list https://briankeating.com/list to win a real 4 billion year old meteorite! All .edu emails in the USA

3 FREE MLB Picks & Predictions by Brandon Cech, Saturday 6/1/24

Josef Kordík je katolický duchovní, spisovatel, disident a přeživší persekucí komunistického režimu: „Vypadá to, že mi Bůh vymetal všudy, kudy jsem šel. Všecko špatné je k něčemu dobré,“ myslí si. V roce 1978 se rozhodl podepsat Chartu 77, což následně vedlo k jeho vyloučení z církve a k trestnímu stíhání. Státní bezpečnost ho opakovaně vyslýchala a sledovala.

In episode #257, we come full circle and welcome back the original co-host of the Glass and Out Podcast, Kelvin Cech. We're proud to announce that Cech has rejoined The Coaches Site as our new Manager of Content Collaboration! This comes after he spent four seasons in the Manitoba Junior Hockey League. The first two were spent as the Head Coach and Gm of the Winkler Flyers, where he was awarded Coach of the Year in his first season. From there, he was appointed the Head Coach and GM of the expansion Niverville Nighthawks. Listen as he shares why a growth mindset is integral for coaches, what he learned form coaching in hockey-mad small town, and what to expect from his new role with TCS.

It was so much fun to have Richo Cech on the show to talk about the benefits of Andrographis, also known as the “king of bitters.” Besides all things Andrographis, Richo also covers some gardening advice and even life philosophies. We also hear why Richo loves chilis so much and what he includes in his herbal medicine kit. As a listener, you also have access to Richo's recipe for Andrographis tincture (and you'll hear why this is one of the herbal medicines Richo reached for when he came down with COVID). There's a free, downloadable and printable recipe card available just for you.By the end of this episode, you'll know:► The experience that introduced Richo to the healing power of herbs► Why Richo recommends Andrographis in tincture form► Richo's favorite herbs to cook with► Why observing nature is the foundation to gardening► Why growing just a few plants can be more productive than growing many► The three herbs Richo includes in his antiseptic tincture► and so much more…For those of you who don't already know him, Richard A. (Richo) Cech has dedicated his life to finding, growing and disseminating seeds of medicinal plants, shrubs, vines, trees, and open-pollinated vegetables. He has botanized throughout the US, Canada, South America, Europe, China and Africa in search of native plants and has introduced many unique medicinal herb species to the US. If you'd like to hear more from Richo, which I highly recommend, then head to the show notes where you can get easy links for his website and social media channels. You can also find the transcript for this episode in the show notes and you can access your recipe card for Richo's Tincture of Andrographis at: https://bit.ly/3ViYMTNThis was my first time meeting Richo, but I've been benefiting from his herbal presence for decades from his books, seeds, and plant starts. I grow so many different herbal plants thanks to his company, Strictly Medicinal Seeds, so it was a special delight to finally connect with him in person! I'm thrilled to share our conversation with you today!----Get full show notes and more information at: herbswithrosaleepodcast.comFor more behind-the-scenes of this podcast, follow @rosaleedelaforet on Instagram!The secret to using herbs successfully begins with knowing who YOU are. Get started by taking my free Herbal Jumpstart course when you sign up for my newsletter.If you enjoy the Herbs with Rosalee podcast, we could use your support! Please consider leaving a 5-star rating and review and sharing the show with someone who needs to hear it!On the podcast, we explore the many ways plants heal, as food, as medicine, and through nature connection. Each week, I focus on a single seasonal plant and share trusted herbal knowledge so that you can get the best results when using herbs for your health.Learn more about Herbs with Rosalee at herbswithrosalee.com.----Rosalee is an herbalist and author of the bestselling book

The Nobel Prize winner says communicating scientific ideas to the public is becoming increasingly difficult.

Cechą współczesnej kultury terapeutycznej jest, że wiele określeń charakterystycznych dla procesu terapeutycznego przeniknęło do powszechnego obiegu. Należy do nich określenie „stawianie granic” i to, co się za nim kryje. Zarówno z tym pojęciem, jak i towarzyszącymi mu zachowaniami ludzi stykamy się niemal codziennie w mediach, w życiu prywatnym i zawodowym. W dzisiejszym odcinku podejmuję się […] Artykuł #104 – O stawianiu granic – po stoicku pochodzi z serwisu Ze stoickim spokojem.

Have you ever wondered what it takes to earn a spot in the Olympic Games? Join us as we sit down with Alex, an Olympian, coach, and entrepreneur, who gives us a fascinating look into her journey from the swimming pools of South Africa to the rowing lanes of the Olympics. It's an incredible story of resilience, tenacity, and the sheer will to succeed, even when the odds seem impossible.Alex's remarkable transformation from an athlete to a coach and finally to an entrepreneur is nothing short of inspiring. Hear about her relentless pursuit of her Olympic dream that didn't falter even after he transitioned into coaching. Her journey to stand shoulder to shoulder with the world's best athletes on the starting line of the Games is a testament to the power of perseverance. He also takes us along on her introspective journey post-Olympics, revealing how it led him on a new path to coaching.Tune in to learn more about:Difference between the beauty and  love she had for swimming and rowingWhat Alex aspired from rowing after it became alive in her lifeHer love for beauty and excellence and how when it faded, it clouded her performanceWhere she had placed her academic life in pursuit of her sporting dreamWhy does she have the what else mindset even whilst being focused on going to the OlympicsHer business ventures after moving on from sportsThe extent she was fearful and scared of her newfound business ventures and how she went about it Why you should prioritize celebrating every win as you match the result…and so much more!Are you looking for Career Clarity for your next step, for more information, or to book a consultancy, make sure you check out http://www.2ndwind.io Links:LinkedIn:https://www.linkedin.com/in/alex-cech? 

Jakie cechy powinien mieć przedsiębiorca? Co pomoże mu stworzyć i rozwinąć własną firmę? Poznaj 8 cech, które ułatwią życie osobom prowadzącym własny biznes i dowiedz się, jak możesz rozwijać te cechy u siebie, żeby osiągać sukcesy jako solprzedsiębiotca. Pełny opis odcinka MWF 439: https://l.malawielkafirma.pl/p-439 W tym odcinku: (2:08) Cechy, które powinien mieć przedsiębiorca i które odnoszą się do niego samego (22:32) Cechy przedsiębiorcy przydające się w relacjach z innymi ludźmi Sponsorem odcinka jest warsztat System Pozyskiwania Opinii Klientów: https://sklep.malawielkafirma.pl/pozyskiwanie-opinii/ Posłuchaj też: 223: Czy powinieneś zakładać własną firmę? | Agata Dutkowska https://l.malawielkafirma.pl/p-223 300: Jak przetrwałem 15 lat jako przedsiębiorca https://l.malawielkafirma.pl/p-300 212: Szybki sposób na poprawę swojej efektywności | Dominik Juszczyk https://l.malawielkafirma.pl/p-212 Bądźmy w kontakcie: Newsletter: https://l.soloprzedsiebiorca.pl/p-439 YouTube: https://l.malawielkafirma.pl/p-youtube

On this episode of Plant Stories on Herbal Radio, we had the opportunity to speak with the acclaimed and enthralling herbalist, Richo Cech. We dive deep into Richo's life and passions, discussing everything from his seed-seeking adventures in Africa, to captivating stories of how he grew Strictly Medicinal Seeds from the ground up (pun-intended). Richo Cech started his professional work as an archaeologist and ethnobotanist in East Africa. Upon his return to the United States in 1978, he began cultivating and saving the seed of medicinal plants. Over the years, his gardens have become the basis for Strictly Medicinal Seeds, growers of organic, open pollinated and GMO-free seed and plants of medicinal herbs, culinary herbs, succulents, trees, and garden vegetables. Richo and his family produce a popular, bi-yearly, hand-illustrated seed catalog that provides access to this collection of common, quirky, eclectic, and bizarre seeds and plants. Richo is author of “Making Plant Medicine” (2000), “Growing At-Risk Medicinal Herbs” (2002), and “Growing Plant Medicine” (2009). Richo has botanized in China and Africa, resulting in the introduction of many new and exciting medicinal herb species to gardeners throughout the world. Visit Richo Cech at: https://strictlymedicinalseeds.com/ https://www.instagram.com/strictlymedicinalseeds/   Join our community! Subscribe to the Mountain Rose Herbs newsletter Subscribe to Mountain Rose Herbs on YouTube Follow on Instagram Like on Facebook Follow on Pinterest Read the Mountain Rose Herbs blog Follow on TikTok Strengthening the bonds between people and plants for a healthier world. Mountain Rose Herbs www.mountainroseherbs.com

Programa completo de Por Fin No Es Lunes con Isabel Lobo cerrando esta temporada. Hacemos un repaso por la historia de la democracia con Gonzalo Bravo Castañeda, catedrático emérito de Historia Antigua en la Universidad Complutense de Madrid y Noelia Gómez  recorriendo  las máquinas para votar que existen; Aprendemos a desconectar con Ana Ibáñez y nuestro sospechoso habitual, Sabino Méndez, reflexiona sobre el arte de despreocuparse; Buscamos el paraíso con Mikel Izal, incluso hacemos ''barcostop'' en la Carretera Secundaria de Eva García;  Alaska nos pone a bailar con las ''fiestas del prao'', Mario Viciosa habla de la siesta ideal y Rebeca Marín juega con los oyentes en sus Pasatiempos Modernos; Sara Escudero nos propone unas vacaciones de película, nos reencontramos con Cechú, el niño de Médico de Familia, y Pablo Pombo nos recuerda que pronto será lunes. 

Join the Bioactive Community: patreon.com/cannabichem Nothing in this podcast is medical advice, ask your doctor before trying any new products. For centuries indigenous cultures have revered the power of natural products and in more recent years scientists have noted the chemical synergies of natural products. However, it can be VERY difficult to study these chemical synergies because to complete research you typically try to limit the amount of variables, which leads to a reductionist approach. Today I sit down and chat with Dr. Nadja Cech. Dr. Cech is a Patricia Sullivan Professor of Chemistry at UNC Greensboro and an active researcher in the field of natural product chemistry. She has published work on a variety of medicinal plants including kratom, goldenseal, echinacea, and now the synergies between phytochemicals within different plant species. Please feel free to ask questions on the YouTube page or on Patreon. LINKS Join the Bioactive Community: patreon.com/cannabichem BOVEDA humidity packs for cannabis: https://bovedainc.com/ Papers:synergies paper by Dr. Cech's lab: https://pubmed.ncbi.nlm.nih.gov/31187844/ Echinacea alkylamides act on CB2 receptors: https://pubmed.ncbi.nlm.nih.gov/16547349/

Are you sure you know what all those inactive ingredients on the label are? We're a little puzzled ourselves. It's why Dr. Nina Botto has joined us this week to break down the many causes of contact dermatitis. Listen in as she discusses patch testing, picking brands, and why “natural” doesn't always mean “safe.” Each Thursday, join Dr. Raja and Dr. Hadar, board certified dermatologists, as they share the latest evidence based research in integrative dermatology. For access to CE/CME courses, become a member at LearnSkin.com. Nina Botto, MD has an active clinical practice in general dermatology and a special interest in allergic contact dermatitis. She is the Director of the Occupational and Contact Dermatitis Clinic, where she brings her expertise in contact dermatitis to patients referred for patch testing and complex inflammatory dermatoses. She is also an Ambulatory Executive Medical Director for UCSF Health. She has served on the board of the American Contact Dermatitis Society and is a member of the North American Contact Dermatitis Group- a patch testing research consortium.    In addition to her dermatologic academic pursuits, Dr. Botto believes that the relationship between the patient and provider is of vital importance to healing and optimized care. She is interested in enhancing the patient and provider experience. She has organized and led efforts focused on service excellence within the Dermatology Department, and is a member of UCSF's CECH organization, which focuses on improving communication skills among providers throughout the University to better healthcare experiences for patients, families and the healthcare team.   Dr. Botto is also a Co-founder of Vetted Dermlab, a hypoallergenic skin skincare company.

Każdy z nas ma narcystyczne cechy. – Narcyzm to jest cecha, która ma rozkład normalny w populacji. To znaczy, że większość ludzi ma tego narcyzmu „średnio”, jest niewielka część, która ma bardzo mało narcyzmu i część, która ma bardzo dużo – mówi w Radiu Naukowym prof. Anna Czarna z Instytutu Psychologii Stosowanej Uniwersytetu Jagiellońskiego. Uczona zajmuje się psychologią społeczną i osobowości, Ciemną Triadą w szczególności społecznym postrzeganiem narcyzmu. Nasilenie narcyzmu uznaje się za patologiczne wtedy, staje się to przeszkodą w życiu jednostki i otoczenia. Bo bycie narcyzem to „praca” 24 godziny na dobę. Narcyzi stale potrzebują potwierdzania swojej wyjątkowości. Cechą charakterystyczną są tzw. wysiłki autowaloryzujące, mające na celu podniesienie własnej samooceny, upewnienie się co do swojej wartości przez cudzy podziw. - Przy czym, przy bardzo wysokim poziomie narcyzmu trudno uniknąć też momentów całkowitego zwątpienia i nienawiści do siebie – dodaje prof. Czarna. Dlatego narcyzi mogą cierpieć na stany lękowe, depresję. Rozmawiamy o tym, co wiemy na temat przyczyn narcystycznego zaburzenia osobowości, jakie może być jego ewolucyjne wyjaśnienie, o tym czy narcyza można przekonać do tego, że nie jest doskonały i wiele innych, a także dlaczego narcyzi początkowo są tak atrakcyjni społecznie. Polecam!

Echinacea is one of the most beloved of medicinal plants in North America, long used in folk medicine for its immune-boosting effects. But did you know that echinacea also has a microbiome—a community of microbes living in and on it—that influences its chemistry and medicinal properties? I speak with plant chemistry expert, Dr. Nadja Cech, about plant microbiomes, chemical signatures of plants, and how the thousands of  molecules found in a single plant work together in synergy. You can follow Dr. Cech's work on Twitter at @nadjacech. Join us this June at the Joint Conference of the Society for Economic Botany and Society of Ethnobiology meeting. Lock in the best rates with early registration by April 15th! #echinacea #medicinalplants #plantchemistry #synergy #podcast #microbiome #nadjicech #CassandraQuave

Miya Cech & YaYa Gosselin recently joined host Elias in the cave! You can catch Miya and YaYa as Jade amd Sam on AppleTV+ 'Surfside Girls' now streaming. Sufside Girls - Surfside Girls is an adventure series about two best friends, Jade and Sam, who are psyched to spend their summer riding the waves and catching the rays. That is until they meet a ghost. The girls dive head first into a mystery about a pirate ship and the cursed treasure that allegedly lies beneath Surfside's beloved Danger Point bluff. After meeting a pirate ghost named Remi, Sam wants to help him break the curse while Jade is determined to find a scientific explanation for the existence of ghosts. To solve the mystery, Sam and Jade will need to combine their very different approaches of logic and imagination. Because together, they are determined to connect the clues, solve the mystery and save Surfside… and maybe they'll help a couple of pirate ghosts along the way. You can watch this interview on YouTube  https://youtu.be/FewFgWrR6A8 Have a question? Email us  themccpodcast@gmail.com Follow us on Social Media for the latest show updates  www.twitter.com/themccpodcast www.instagram.com/themccpodcast www.facebook.com/themancavechroniclespodcast www.themccpodcast.com  www.youtube.com/c/TheManCaveChronicleswElias