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When sharing a fresh loaf of hot bread from the oven that's love! Our Daily Bread Foundation supports underserved youth in Charlotte, Mecklenburg. See all of their programs on their official website.  That lovely vision came from Kim Alexander with Our Daily Bread Foundation who is bringing the community together as we understand how trauma affects all of us.  Kim Alexander says we can no longer put a band-aid on our wounds. We cannot turn a blind eye to mass killings, mental illness, discrimination, refugees, shortage of affordable housing, lack of affordable healthcare, prison overpopulation, and recidivism. BACKGROUND: For over a decade Social Venture Partners Charlotte (SVP Charlotte) has fostered social entrepreneurs and innovative solutions to our community's greatest challenges. See all the nonprofits featured in the SEED20 Class of 2024!

Are you connected with your inner self? No. If you do not know yourself, how do you expect to be a good leader? One of the biggest assets you can give to others is being true to yourself and knowing who you are as a person. Why is this so important? In this episode of the INT podcast, host Linda Yates speaks with Olivia Smith, founder of Healing House, on the importance of women leaders knowing themselves. Discover how to become a better leader by developing this skill in this week's episode. Olivia Smith's Background For twelve years, she worked in the nursing field and left after having children. After becoming a stay-at-mother, Olivia struggled with her inner self.  She enjoyed being at home with her children, but she was lost within herself. After finding a hobby, she discovered how to make money with it and soon turned it into a six-figure business. Self-Awareness and Personal Growth When starting her nonprofit business, Olivia learned to recognize and acknowledge her strengths and weaknesses. This allowed her to transition the leadership position of her nonprofit to someone else. She also shares it's essential for leaders to recognize when they are not in their wheelhouse and to take action to remove themselves from a situation in which they don't fit in.  Olivia further compares this skill with other experiences to help highlight the importance of self-reflection. Leadership Styles and Communication in the Workplace Olivia believes that understanding one's own communication style and how to adapt to others is crucial for effective leadership, leading to improved employee retention and a more productive work environment. She recognizes that leaders often unknowingly create a toxic culture by using language that can be intimidating or frightening to their team members. She suggests that leaders should be aware of their own personality styles and how they may impact their communication with team members. In addition, leaders should try to create a safe and trustworthy environment for everyone. Leadership Development, Self-Awareness, and Personal Growth Olivia provides coaching and consulting services to help individuals overcome self-doubt and impostor syndrome, which can stem from past experiences and be deeper than just work-related issues. She works with individuals to identify the root causes of their struggles and provides a process of work over time to help them overcome these challenges. Olivia emphasizes the importance of finding something outside of mothering to help cope with the emotional demands of staying at home and how this enabled her to work through her struggles. In this episode of the INT podcast, you'll hear an empowering story about Olivia Smith and how she became a better leader by developing one essential skill that most leaders lack. Tune in and discover the importance of investing in self-awareness to help you develop better leadership skills. “Investing in knowing more about yourself is like the advice they give you on the plane when they say put your own oxygen mask on first before you can help anyone else. Know who you are first. Before you try to lead others, you'll be a better leader, you'll be a better parent, there'll be a better spouse. If you become much more clear on who you are and how you're coming across to other people, and being honest about that, and seeing that as a growth opportunity.” -Olivia Smith Resources www.writeanewstory.com Olivia Smith on Facebook Olivia Smith on Instagram Olivia Smith on LinkedIn If this episode connected with you, reach out to Linda and let her know. This podcast is produced by TSE Studios. Check out other podcasts by TSE Studios, including this episode's sponsor, The Sales Evangelist, helping new and struggling sellers close more deals and achieve their sales goals. Subscribe to the IntHERrupt Podcast so you won't miss a single show. Find us on Apple Podcast, Google Podcast, Spotify, and Stitcher. Audio created by Ryan Rasmussen Productions.   

Share this episode of Labor Relations Radio with your colleagues.Episode summary: In this episode of Labor Relations Radio, Jon Morrow, a free-market economist who has consulted with a variety of organizations—including the Council on Foreign Relations, the Trilateral Commission, the Economic Innovation Group and others—discusses a wide variety of economic topics such as the falling birthrates, AI, the debt-financed economy, fiat currencies, as well as cultural and political obstacles to lower energy costs and general prosperity.Background: For decades, a shift in demographics has been occurring across much of the Western World as the “baby boom” generation retires and successor generations have fewer and fewer children. These inverse population pyramids threaten to bring national economies to a halt and, according to one geopolitical analyst, will cause the global economy to collapse. “Such declines will soon shock our economic infrastructure and lead to deteriorations in living standards,” noted Fast Company in 2021.Is the advent of artificial intelligence (AI) a possible solution, or will AI be the trigger to a calamitous future, including an economic recession or even a depression?Listen to this episode and draw your own conclusions.For all prior episodes of Labor Relations Radio, go here.LaborUnionNews.com's Labor Relations Radio is a subscriber-supported podcast. To receive new episodes and support our work at LaborUnionNews.com, please consider becoming a subscriber. Get full access to LaborUnionNews.com's News Digest at laborunionnews.substack.com/subscribe

Episode summary: In this episode of Labor Relations Radio, Jon Morrow, a free-market economist who has consulted with a variety of organizations—including the Council on Foreign Relations, the Trilateral Commission, the Economic Innovation Group and others—discusses a wide variety of economic topics such as the falling birthrates, AI, the debt-financed economy, fiat currencies, as well as cultural and political obstacles to lower energy costs and general prosperity.Background: For decades, a shift in demographics has been occurring across much of the Western World as the “baby boom” generation retires and successor generations have fewer and fewer children. These inverse population pyramids threaten to bring national economies to a halt and, according to one geopolitical analyst, will cause the global economy to collapse. “Such declines will soon shock our economic infrastructure and lead to deteriorations in living standards,” noted Fast Company in 2021.Is the advent of artificial intelligence (AI) a possible solution, or will AI be the trigger to a calamitous future, including an economic recession or even a depression?Listen to this episode and draw your own conclusions.For all prior episodes of Labor Relations Radio, go here.__________________________LaborUnionNews.com's Labor Relations Radio is a subscriber-supported publication. To receive new posts and support our work, consider becoming a subscriber here.

BoF's Imran Amed speaks with Alec Leach about his manifesto on how we can move towards a better relationship with fashion.Background: For nearly five years, author Alec Leach worked as an editor at streetwear website Highsnobiety, where he spent his “career telling people to buy stuff.” Leach saw up close the contribution his content was having on overconsumption and the lack of responsibility brands and consumers took for their own part on the climate crisis, both subjects he tackles in his book, “The World Is on Fire But We're Still Buying Shoes.” “I love working in the industry. I really, really do,” says Leach. “I think we just all need to accept that we're part of this consumerist machine. And once you accept that, then the kind of potential for positive change becomes clearer.” This week on The BoF Podcast, Leach sits down with BoF's founder and editor-in-chief Imran Amed to discuss how the fashion industry and consumers must change. Key Insights:During his time at Highsnobiety, Leach attended several events, including the Global Fashion Summit in Copenhagen, focussed on sustainability in the industry. But for all the discussion of supply chain and new technologies, he felt that there wasn't enough talk about what he saw as the core issue. “No one's really asking why we buy so many things,” he said. “It always comes down to overconsumption.”In Leach's book, he says shopping is part of a consumer's identity because of the role it plays in self expression. “It's important to acknowledge that fashion is intimately connected to our sense of self. That makes shopping a pretty existential experience,” said Amed, quoting Leach's book. According to Leach, the supply chain is a “nonsensical system” that allows brands to take little accountability for their own manufacturing processes. “Brands aren't really that responsible for what happens in their supply chain, and they're not really responsible for what happens to all these clothes when they're no longer wearable,” said Leach. Leach's personal experiences in therapy over the course of years helped him dig deeper while writing his book. “That's where a lot of the more psychological and philosophical elements of the book came out, it was about me being in therapy every day, every week and asking myself some very difficult questions afterwards,” he said.Additional Resources:“The World is On Fire But We're Still Buying Shoes” by Alec Leach: Leach's debut book or manifesto explores society's relationship with overconsumption and how consumers can have a better relationship with fashion. To subscribe to the BoF Podcast, please follow this link. Hosted on Acast. See acast.com/privacy for more information.

Background: For fashion, one of the most alluring prospects for NFTs is how they could help brands collect royalties — forever — on secondary sales of physical goods. Though the mechanics of doing so are not ironed out yet, brands could ideally code NFTs tied to physical products with smart contracts triggered by certain conditions and benefit every time an item is sold, not just at the initial sale. But, technical loopholes used to circumvent loyalties and finicky marketplaces leave brands and creators without ways to enforce rules. “One of the big principles of Web3 is these royalties are the idea that it's a creator led economy, it wouldn't necessarily be controlled by a big centralised organisation … Except that's not really playing out,” said BoF technology correspondent Marc Bain. Key Insights: Marketplaces are responding to controversy over enforcing royalties. Opensea, one of the biggest Web3 marketplaces, wants to attract creators, so it has an incentive to honour creator royalties. Newer marketplaces just looking for sales are willing to cut fees for buyers. This has led to an existential crisis for the NFT community, showcasing that creators are not entirely in charge in a space that was touted as having enormous potential to empower them. Marketplaces and infrastructure for fashion brands that would want to get royalties for secondary sales don't exist right now. It also remains to be seen how brands would scale such a system. A number of start-ups including EON and Aurora Blockchain Consortium are working on linking digital identities to physical goods, but doing so is complicated. Additional resources:Is Fashion's NFT Dream Over Before It Started?How Fashion Is Using NFTs to Sell Exclusive Physical ProductsThe Secrets to a Successful NFT DropJoin BoF Professional today with our exclusive podcast listener discount of 25% off an annual membership, follow the link here and enter the coupon code ‘debrief' at checkout. Want more from The Business of Fashion? Subscribe to our daily newsletter here.Follow The Debrief wherever you listen to podcasts. Hosted on Acast. See acast.com/privacy for more information.

I'm excited to introduce this week's guest, Hedley Thorne. The second time I walked the Ridgeway, I started to think about getting a drone. I love Iron Age hillforts, and I really struggled to photograph them from the ground. Upon my return, I started writing blog posts about hillforts and I discovered Hedley's Instagram account. I absolutely love his photography, and I still fantasize about getting a drone of my own. Photography adds a new layer to our outdoor adventures, and drone photography adds a whole new perspective. I've really enjoyed seeing all of my favorite Ridgeway sites from the air. It makes it easier to really appreciate these ancient sites. I hope you find this episode inspiring! Whether or not you're interested in aerial photography, it might help you to find new ways to enjoy your own outdoor adventures.   About Hedley The basics: Name- Hedley Thorne Age - 46 (by the time of the podcast!) Family - married, 3 teenage boys, living in Didcot Occupation 1- IT Operations Manager/Controller for London Heathrow Occupation 2- Aerial landscape photographer Voluntary work - Chairman of 2410 Air Training Corps committee - Didcot Air Cadets Hobbies- cycling (road or MTB), walking, UAV drone pilot (A2 qualified), aerial photography Likes- F1, chess, music (I used to play piano and did my degree in music/Business), aviation, art Fears- fish, being upside-down, claustrophobic and needle phobic Dislikes- Bitcoin, politics, bad coffee, bad music (life is too short for these)   Background: For 10 years I worked in Henley-on-Thames and road cycled between Didcot and Henley most days, sometimes doing between 60 and 90 miles on a work day which led to many foreign cycling group adventures in the Pyrenees, the Alps, Ventoux, Prince Edward Island in Canada, Mallorca and Teide in Tenerife, however redundancy struck a few years ago and I started working at Heathrow (managing and controlling the daily IT operation, managing major IT incidents that affected the airport etc) which halted cycle commuting and I then became quite unfit. The airport is 24x7 and so doesn't recognise weekends or times of the day so shifts are very long and at bad times, often overnight. Ultimately my big adventures dwindled and I had to replace the cycle commuting with something more manageable.   Introduction to photography of The Ridgeway: I live in South Oxfordshire near to The Ridgeway long distance path and since working at Heathrow I started using my days off work to walk along it. The kids (teenagers!) were at school and my wife Hayley was working so I had some days to myself. As I walked different stretches of The Ridgeway my relationship with it grew and I started looking closely on the web at the areas I walked in - many results came back with pictures from renowned landscape artist Anna Dillon and I quickly became a bit of a fan of her work, sometimes using it to guide and plan my walks, which expanded out into The Chilterns, Berkshire, Hampshire and Wiltshire.   I found my walks (and more recently mountain bike rides) helped balance out work and then ultimately became a necessity- stress levels dropped and I had space to think. I tried to replicate some of Anna's artwork taking mobile phone pictures. Then, my love of anything that flies, led me to buying a drone (well, initially using one that I had bought for one of my sons!). The aerial shots of these areas added a really unique dimension to the landscape and I quickly realised that these were views that had probably not been seen before, and I was the first to witness them.   Partnership with Anna Dillon: As I grew my Instagram and Twitter social media accounts using my new found aerial photography, Anna noticed one of my pictures of Wittenham Clumps and got in touch, asking whether she could commission it for a painting - I couldn't say "yes" fast enough! The originality of aerial landscape pictures along The Ridgeway became even more exclusive when distilled into a work of art and we both realised this through feedback. This ultimately led to our "Wessex Airscapes" exhibition at the Sewell Centre Gallery in Radley College through September 2021 just after lockdown restrictions eased in the UK, and the response to the exhibition, particularly our opening night, was terrific.   Leading up to the exhibition we teamed up with Pipstick Walks to lead a series of hikes around the Lowbury Hill area of The Ridgeway which has a very dark and rich history and formed the centrepiece of the show. We are now in the process of preparing for future events- notably a second iteration of "Wessex Airscapes" exclusive to Wiltshire, and to be held at the Wiltshire Museum in Devizes in 2023, and before then Oxfordshire Artweeks at Anna's studio in South Oxfordshire. We also have other projects on the boil relating to Uffington White Horse Hill and Grim's Ditch.   Injuries, and areas of interest: The last 2 years have been rough for me if I am honest. I suffered two injuries during my walking and cycling requiring extensive surgery on my wrist on 2 occasions (no general anaesthetic due to covid restrictions!) and also surgery on my knee for a snapped patella following a fall on White Horse Hill at Uffington - on this occasion the weather was terrible- I updated my situation live on Twitter and had company on there from many, and I was ultimately rescued by a group of brave local villagers from Woolstone (one of whom was an ex military medic with a Landrove Defender), and then I had to guide the emergency services using "What 3 Words".   These injuries, along with Covid restrictions and general lack of self-care led me to become overweight but I have a Mallorca mountain road cycling event next year to work towards and plenty of mountain biking to do over the winter! My favourite areas to ride and walk are The Ridgeway, Lowbury Hill area, Uffington/Waylands Smithy, Tan/Milk hill and nearby areas in Wiltshire, Wittenham Clumps and anywhere along The Thames. I am (as an amateur) interested in the history of these areas and I have become friends with many of the land owners, The Ridgeway Officer and people connected with The Thames from my photography mini adventures , exhibition, social media and picture sales.   My past, my work and my future: Anna's mother has done a genealogy report on my father's bloodline and it turns out that most of my previous generations on that side of the family had strong connections with the countryside, working on farms throughout Berkshire, Hampshire and Wiltshire (with a nod to royalty going far back but that is yet to be confirmed!).   Last year I was supposed to become the Aircraft Operations Duty Manager for Heathrow Airport but unfortunately the airport was massively affected by Covid restrictions and went through large staff cuts, including the role I was moving into which disappeared right before my appointment. This stopped the intensive training that I was undertaking and led me to diverting my learning efforts instead towards developing my photography and learning about the RAF as part of my duties as Chairman of the local Air Training Corps committee (Air Cadets).   Looking to the future I want to walk or cycle the entire length of The Ridgeway in one go, produce the best pictures that I can for selling on my website and the exhibitions, and also focus on what I want to do in the future at Heathrow.   Beliefs and conflicts: I sit in an awkward position which is constantly the "elephant in the room" for me - I love the countryside, its history and I am passionate about its preservation, yet I sit in the control room helping to run the country's largest airport. But knowing the remarkable people who work at the airport there is a huge and ongoing push towards sustainability that has been enhanced by the big operational reset provided by Covid.   I truly believe that those working for large organisations such as airports towards a more sustainable future are having more of a genuine impact on the environment than those throwing themselves down on the motorway in front of cars, who just seem to serve to make the public angry and detract from the very views they are passionate about. The green spaces around us are smaller than they were just 30 years ago, and yet in this high paced age of transport, industry, communication and construction they are more important now than they ever have been and those who enjoy their presence like me need to actively engage in their preservation.   Website Twitter Instagram   Listen To This Episode        What You'll Learn How Hedley combines cycling, hiking, and aerial photography Why the Ridgeway is such a great place for drone photography How to get started with aerial photography Everything you need to invest in to get started Good starter equipment—and how to upgrade  How to use Google Earth to plan your shots in advance Drone etiquette—where not to fly and what not to do Hedley's top tips for getting into drone photography   Things We Discussed Waylands Smithy Wittenham Clumps Anna Dillon Wessex Airscapes exhibition Lightroom Uffington White Horse hill Barbury Castle CAA drone test DJI Drones A2 CofC course Altitude Angel app DJI Mini 2 DJI Air 2S DJI Mavic 3 Earth Trust Brightwell Barrow Henley on Thames Lowbury Hill Pewsey Downs   Related Episodes 435 Chris Bedford ~ Adventures With Abandoned Railways 430 Sue-Ann Hickey ~ Adventures in Solo Cycling Tours 426 Doris Lance ~ Nature Bathing for the Five Senses 421 Cara Wilde ~ Adventures With Stone Circles   Connect With Holly Website Facebook Instagram Twitter Pinterest Google+ LinkedIn   How to Subscribe Click here to subscribe via iTunes Click here to subscribe via RSS Click here to subscribe via Stitcher   Help Spread the Word If you enjoyed this episode, please head on over to iTunes and kindly leave us a rating and a review! You can also subscribe, so you'll never miss an episode.

Background For continued growth and development, hospital pharmacist would benefit from leadership training Pharmacy schools provide some administrative training Hospital pharmacist may one day want Continue reading The post Episode 40: Leveling Up As a Clinical Staff Pharmacist by oscar Santalo and Jimmy Pruitt appeared first on The Pharm So Hard Podcast.

Today we will be go more in depth about my anxiety. This episode will dive in the ways of discovering this wave of depression and where it steams from. I'm sharing details of my life to allow others to not feel alone in tough, confusing circumstances. Background: For the past 6 years I was my father's caregiver. I would look after him all day and all night. Cooking meals, washing clothes, being head of the house hold almost. While experiencing this I grew a deeper bond with my father but I lost myself in caring for him. During this time I grew adjusted to a routine that would later put a pause on my growth. Now that my father has 'gone home,' I have to figure out how to pick up pieces of my personality I left behind. Now I have started a podcast to talk and share with you all to help my journey. Information: Lyric Lee Age:30 Occupation: Film and Video production Social Media: Instagram: lyriclee_indigo Twitter: lyriclee_indigo Youtube Channel: Lyriclee STUDIO Music Intro: Producer TXRRY NICE

Jacqui Cooper (Host of JCooperTravels & Love Travel Scotland) speaks with Yvette MacDonald (Scotland Entrepreneur) about her recent trip to visit Spynie Palace and what she discovered on her road trip north. Be sure to connect with Love Travel Scotland Facebook Group: https://www.facebook.com/groups/lovetravelscotland To connect with either Jacqui or Yvette, email at jcoopertravels@gmail.com. Background: For nearly 500 years, the bishops of Moray relaxed in this majestic building a short distance from their cathedral at Elgin. It even had its own bowling green and, according to one account, a tennis court. Today, you can climb David’s Tower, where bishops once entertained kings and queens. --- Send in a voice message: https://anchor.fm/jacqui-cooper/message Support this podcast: https://anchor.fm/jacqui-cooper/support

Jacqui Cooper (Host of JCooperTravels & Love Travel Scotland) speaks with Yvette MacDonald (Scotland Entrepreneur) about her recent trip to visit Spynie Palace and what she discovered on her road trip north. Be sure to connect with Love Travel Scotland Facebook Group: https://www.facebook.com/groups/lovetravelscotland To connect with either Jacqui or Yvette, email at jcoopertravels@gmail.com. Background: For nearly 500 years, the bishops of Moray relaxed in this majestic building a short distance from their cathedral at Elgin. It even had its own bowling green and, according to one account, a tennis court. Today, you can climb David's Tower, where bishops once entertained kings and queens. Very occasionally the property has to close at short notice due to adverse weather conditions or other reasons out with our control. #Scotland #Palace #Travel --- Support this podcast: https://anchor.fm/lovetravelscotland/support

Today we will be exploring my thoughts on sharing your testimony. This episode will dive in the ways of being transparent and sharing details of my life to allow others to not feel alone in tough, confusing circumstances. Background: For the past 6 years I was my father's caregiver. I would look after him all day and all night. Cooking meals, washing clothes, being head of the house hold almost. While experiencing this I grew a deeper bond with my father but I lost myself in caring for him. During this time I grew adjusted to a routine that would later put a pause on my growth. Now that my father has 'gone home,' I have to figure out how to pick up pieces of my personality I left behind. Now I have started a podcast to talk and share with you all to help my journey. Information: Lyric Lee Social Media: Instagram: lyriclee_indigo Twitter: lyriclee_indigo Youtube Channel: Lyriclee STUDIO Music Intro: Producer TXRRY NICE

Today we will be exploring my thoughts on being a professional procrastinator. This episode is an introduction and a spill on what I have done to rush my life into panic mood. Background: For the past 6 years I was my father's caregiver. I would look after him all day and all night. Cooking meals, washing clothes, being head of the house hold almost. While experiencing this I grew a deeper bond with my father but I lost myself in caring for him. During this time I grew adjusted to a routine that would later put a pause on my growth. Now that my father has 'gone home,' I have to figure out how to pick up pieces of my personality I left behind. Now I have started a podcast to talk and share with you all to help my journey. Information: Lyric Lee Social Media: Instagram: lyriclee_indigo Twitter: lyriclee_indigo Youtube Channel: Lyriclee STUDIO

Welcome all, Today we will be exploring my thoughts on being isolated and staying in the house before it was a pandemic. Do you feel safer being alone? This episode is an introduction and a spill on what I learned about being isolated. Background: For the past 6 years I was my father's caregiver. I would look after him all day and all night. Cooking meals, washing clothes, being head of the house hold almost. While experiencing this I grew a deeper bond with my father but I lost myself in caring for him. During this time I grew adjusted to a routine that would later put a pause on my growth. Now that my father has 'gone home,' I have to figure out how to pick up pieces of my personality I left behind. Now I have started a podcast to talk and share with you all to help my journey. Information: Lyric Lee Social Media: Instagram: lyriclee_indigo Twitter: lyriclee_indigo Youtube Channel: Lyriclee STUDIO

Welcome all, Today we will be exploring my thoughts on being a caregiver and how it has changed me. Sometimes people lose themselves and I am here to talk about it. This episode is an introduction and a spill on what I learned about myself. care·giv·er /ˈkerˌɡivər/ a family member or paid helper who regularly looks after a child or a sick, elderly, or disabled person. Background: For the past 6 years I was my father's caregiver. I would look after him all day and all night. Cooking meals, washing clothes, being head of the house hold almost. While experiencing this I grew a deeper bond with my father but I lost myself in caring for him. During this time I grew adjusted to a routine that would later put a pause on my growth. Now that my father has 'gone home,' I have to figure out how to pick up pieces of my personality I left behind. Information: Lyric Lee Social Media: Instagram: lyriclee_indigo Youtube Channel: Lyriclee STUDIO

In this episode of ‘ADAM VS THE VRILOCK!’…Adam Kokesh faces off with psionic outlaw Tom Vrilock on the topic of freedom vs slavery! (No, not really. We’re just having a chat. But you never do know! Muwahahahaaa! )—About Tonight’s Show!—Herr Doktor von Vrilock surprises us once again with his immutable brilliance! And in his indisputably divine wisdom, Vrilock welcomes to our program the libertarian presidential candidate and U.S. Marines veteran Adam Kokesh! Adam is the host of ‘Adam vs the Man!’ And tonight we’re talking Freedom vs Enslavement! Are we free yet? Well, tune in to find out where we’re all headed!—Background—For those who are unfamiliar with the story which brought into contact these two unlikely fellas, it can be summarized as follows: Adam Kokesh who is a freedom loving American was wrongfully incarcerated after demonstrating his right to bare arms in D.C., and Doc Vrilock worked 4 hours a day with the Miraculous Prayer Board to free this hero from bondage. Adam Kokesh, former libertarian candidate for the position of President of the U.S.A. is a veteran of the US Marines who served in the Iraq War. Adam is also the host of Adam vs. the Man! once a television show that is now produced on his web site Adamvstheman.com, produced M-F, 9am-11am. Adam is a libertarian human rights activist with a message for waking up his fellow Americans to a true world tyranny! https://thefreedomline.com/ is Adam’s main web site! And you can listen to his audiobook here at https://thefreedomline.com/freedom/ But of course you’ll find all manner of positive ventures and noble pursuits (such as Adam’s geo dome construction business and his Garden of Freedom) when you follow Adam Kokesh on Twitter @adamkokesh—Support!—If you enjoy these podcasts please patronize the Vrilock Psionics Shop and see what goodies we have for your mind empowerment pursuits! Shop at Vrilock.com/shop  Thank you for joining us on Planet Vrilock tonight! And until next time…#KeepTheMagickHigh! KEEP THE MAGICK HIGH!V.P.S. Be like The Avengers! Harness the willpower of a Green Lantern against all fear! Master the Force like a Jedi Knight to bring life back into balance! Join the Psionic Brotherhood and train up in the Vrilock Club! Vrilock.club and Keep The Magick High! 

HSAY 018 - Rev. Michel Faulkner - NY mayor candidate | Republican | NFL Athlete Quote: “For New yorkers, it's not just ‘our' city, it actually belongs to the world!” Background: For more than 30 years, Rev. Michel Faulkner has dedicated his life to serving his community. Michel Faulkner is the only Republican candidate for Mayor of New York City, a former New York Jet and businessman. His Church in Harlem is responsible for thousands of people finding employment through their Jobs Partnership. Michel supports school choice and is a strong and vocal advocate for the Police. Highlights: Candidate for mayor of new york Positive uplifting and timely messaging on social media ---? NY is a world capital - Everybody comes to new york sometime or another For New yorkers, it's not just ‘our' city, it actually belongs to the world. Michel  is working on NY being an expensive city. Making it more accessible. Been working to serve the people of NY for the past 30 years. He thinks NY needs to have principal leadership - the focus being on - jobs, education, tax reforms, on making things better so NY can move forward. The culture and ambience of the city can be enhanced. It is diminished right now because of the plaguing issues they've been facing recently. Michel  is running to help the middle class survive in NY, enhance the ambience and revive true culture of the city. “I'm a New Yorker, I have a NY attitude and NY values”, says Michel “I value all people, the dignity of all people, their worth.” “I don't care what their political persuasion is, their ethnicity is, their socio-economic status, or their sexual orientation, what matters to me is healing new york.” “Unity is our destiny” “We need to be selfish and focus on maintaining structural and cultural integrity of NY” “NY is a place of hardworking people, if you have a dream and are willing to work hard to bring that dream to life, you should have a chance to do that in NY.” “NY has always been accepting of dreamers. I'm a dreamer, pragmatic dreamer” “Everybody has a job and a hustle in New York” and that's a youth culture Michel  stressed upon. “We've made some amazing gains and strides. We cannot let it slip by. We need to move forward.” There has been a diminishing return on education system, students of public schools are unprepared when they graduate. Michel  will look into jobs and education. “The best way to empower citizens is to connect them with the police”, Michel  will work to enhance police-community relations. “NYPD is the best in the world with what they do” “We started the blue ribbon campaign for the unity in police community. It focused on 3 things- Affirmation of police officers, Appreciation of their jobs, accountability - police being accountable and citizens being responsible citizens” Michel  started tweeting and let people engage with each other at the time of the haiti quake - Provided food and help to people who were starving. Social media is a great enhancer for community relations. Big challenge is to get people behind social media to actually come out and take action and interact in communities. Social media works best when receivers are dynamic participants “More or less social because of social media ?” “I started a group called NY youth leaders network - used snail mail because there were no cell phones back then. People read the mail and took action.” 140 characters can change stock markets, bring notice to the entire globe. Traditional media stands shaken. The mayoral race is not about what's wrong with NYC but about preserving what is right with NYC. “I will raise the level of engagement of stakeholders in NYC. It won't be passive, it will  be dynamic, there will be action groups, social media groups, people will be able to raise their voices, their concerns and we will fix what is broken and hence move NY forward.” I am a great listener of people as long as we all are speaking the same language of healing the great city of NY. Connect: Twitter: @michelfaulkner and @FaulknerMayor2017 Facebook: https://www.facebook.com/michel.faulkner/ Website : http://faulknerfornewyork.com/ I hope you enjoyed and found value on this episode of The How Social Are You Podcast please feel free to share it on social media with your followers. You can find us on iTunes, Stitcher, Spreaker, SoundCloud and Google Play. Your ratings and comments on iTunes are greatly appreciated. If you have questions about The How Social Are You Podcast or would like to be interviewed you can tweet or direct message me on GAB the new People First / Free Speech Social Network https://gab.ai/ at @ML as well as on Twitter @mlindheimer or on Instagram @mlindheimer and lastly on Facebook melindheimer and you can also email me at mlindheimer@gmail.com.   Until next time, thank's everybody!Support this show http://supporter.acast.com/the-how-social-are-you-podcast. Hosted on Acast. See acast.com/privacy for more information.

Background: For the treatment of the severe infantile coxa vara it is mandatory for the orthopaedic surgeon to observe the mechanobiology of the growing hip before and after the surgical intervention. We hereby would like to present our experiences with the subtrochanteric end-to-side valgization osteotomy and to compare the procedure with the alternatively used Y-shaped osteotomy as described by Pauwels. Methods: Thirteen patients (20 hips) who had undergone subtrochanteric end-to-side valgization were followed for a mean 6.2 years (range, 0.8 to 12.8 y). At the time of surgery the mean age was 7.1 years (range, 2.0 to 13.3 y), last follow-up examination was performed at a mean of 13.4 years of age (range, 5.1 to 18.3 y). The deformities were etiologically based on 5 entities: congenital coxa vara (n = 1), osteochondrodysplasias (n = 12), postosteomyelitic coxa vara (n = 5), and avascular femoral head necrosis in the course of congenital dysplasia of the hip (n = 2). The follow-up rate was 100%. In addition, we analyzed a total of 93 pelvic radiographies with a total of 139 hip joints. Thirty angles and distances were assessed according to parameters described in the literature. Results: Although preoperatively 12 patients presented with a positive Trendelenburg's sign, it was only present postoperatively in 2 patients. Duchenne's limp reduced from 10 to 1. All of the 15 preoperatively apparent nonunions could be healed by means of surgery. Two hips redeveloped pathologically lowered collodiaphyseal angles postoperatively, one of which had to undergo revision surgery. Preoperatively 15 out of 20 patients (75%) showed nonunions all of which healed after surgery. No recurrence could be seen at the time of the last follow-up. The following angles were assessed on plain radiographies of the pelvis preoperatively and directly postoperatively as well as on the last follow-up at a mean of 85 months: CCD-angle 98 degrees/156 degrees/144 degrees, EY-angle 55 degrees/5 degrees/15.7 degrees, AY-angle 32 degrees/75 degrees/66 degrees, CE-angle 20 degrees/25 degrees/18 degrees, AC-angle 20 degrees/18 degrees/20 degrees. The articulotrochanteric distance was 5 mm/26 mm/14 mm. Conclusions: The subtrochanteric end-to-side valgization osteotomy showed to be highly effective in the management of the infantile coxa vara, improving the clinical impairment of the patients postoperatively. All of the preoperatively present nonunions showed osseous consolidation at follow-up examination. Only minor revarization tendencies could be found. The procedure is technically less demanding, safer and more efficient regarding the lengthening of the affected limb in comparison to the Y-shaped intertrochanteric osteotomy as described by Pauwels. Level of Evidence: Case-control study (EBM-level III).

Background: For future eradication strategies of malaria it is important to control the transmission of gametocytes from humans to the anopheline vector which causes the spread of the disease. Sensitive, non-invasive methods to detect gametocytes under field conditions can play a role in monitoring transmission potential. Methods: Microscopically Plasmodium falciparum-positive patients from Jimma, Ethiopia donated finger-prick blood, venous blood, saliva, oral mucosa and urine samples that were spotted on filter paper or swabs. All samples were taken and stored under equal, standardized conditions. RNA was extracted from the filter paper and detected by real-time QT-NASBA. Pfs16-mRNA and Pfs25-mRNA were measured with a time to positivity to detect gametocyte specific mRNA in different gametocyte stages. They were compared to 18S-rRNA, which is expressed in all parasite stages. Results were quantified via a known dilution series of artificial RNA copies. Results: Ninety-six samples of 16 uncomplicated malaria patients were investigated. 10 (66.7%) of the slides showed gametocyte densities between 0.3-2.9 gametocytes/mu l. For all RNA-targets, molecular detection in blood samples was most sensitive; finger-prick sampling required significantly smaller amounts of blood than venous blood collection. Detection of asexual 18S-rRNA in saliva and urine showed sensitivities of 80 and 67%, respectively. Non-invasive methods to count gametocytes proved insensitive. Pfs16-mRNA was detectable in 20% of urine samples, sensitivities for other materials were lower. Pfs25-mRNA was not detectable in any sample. Conclusions: The sensitivity of non-invasively collected material such as urine, saliva or mucosa seems unsuitable for the detection of gametocyte-specific mRNA. Sensitivity in asymptomatic carriers might be generally even lower. Finger-prick testing revealed the highest absolute count of RNA copies per mu L, especially for Pfs25-mRNA copies. The method proved to be the most effective and should preferably be applied in future transmission control and eradication plans. A rapid test for gametocyte targets would simplify efforts.

Background: For the pharmacological treatment of bipolar depression several guidelines exist. It is largely unknown, to what extent the prescriptions in daily clinical routine correspond to these evidence based recommendations and which combinations of psychotropic drugs are frequently used. Methods: The prescriptions of psychotropic drugs were investigated of all in-patients with bipolar depression (n = 2246; time period 1994-2009) from hospitals participating in the drug surveillance program AMSP. For the drug use in 2010, 221 cases were analysed additionally. Results: From 1994 to 2009, 85% of all patients received more than one class of psychotropic substances: 74% received antidepressants in combination therapy, 55% antipsychotics, 48% anticonvulsants and 33% lithium. When given in combination, lithium is the most often prescribed substance for bipolar depression (33%), followed by valproic acid (23%), mirtazapine and venlafaxine (16% each), quetiapine (15%), lamotrigine (14%) and olanzapine (13%). Both, lithium and valproic acid are often combined with selective serotonin reuptake inhibitors (SSRI), but also with mirtazapine und venlafaxine. Combinations of more than one antidepressant occur quite often, whereby combinations with bupropion, paroxetine, fluoxetine or fluvoxamine are very rare. In 2010, quetiapine (alone and combined) was the most frequently prescribed drug (39%); aripiprazole was administered in 10%. Conclusion: Combinations of antidepressants (SSRI, mirtazapine, venlafaxine) with mood stabilizers (lithium, valproic acid, lamotrigine) and / or atypical antipsychotics (quetiapine, olanzapine) are common. Of most of those combinations the efficacy has not been studied. The use of aripiprazole and the concomitant use of two or three antidepressants contrast the guidelines.

Background: For percutaneously tracheostomized patients with prolonged weaning and persisting respiratory failure, the adequate time point for safe decannulation and switch to noninvasive ventilation is an important clinical issue. Objectives: We aimed to evaluate the usefulness of a tracheostomy retainer (TR) and the predictors of successful decannulation. Methods: We studied 166 of 384 patients with prolonged weaning in whom a TR was inserted into a tracheostoma. Patients were analyzed with regard to successful decannulation and characterized by blood gas values, the duration of previous spontaneous breathing, Simplified Acute Physiology Score (SAPS) and laboratory parameters. Results: In 47 patients (28.3%) recannulation was necessary, mostly due to respiratory decompensation and aspiration. Overall, 80.6% of the patients could be liberated from a tracheostomy with the help of a TR. The need for recannulation was associated with a shorter duration of spontaneous breathing within the last 24/48 h (p < 0.01 each), lower arterial oxygen tension (p = 0.025), greater age (p = 0.025), and a higher creatinine level (p = 0.003) and SAPS (p < 0.001). The risk for recannulation was 9.5% when patients breathed spontaneously for 19-24 h within the 24 h prior to decannulation, but 75.0% when patients breathed for only 0-6 h without ventilatory support (p < 0.001). According to ROC analysis, the SAPS best predicted successful decannulation {[}AUC 0.725 (95% CI: 0.634-0.815), p < 0.001]. Recannulated patients had longer durations of intubation (p = 0.046), tracheostomy (p = 0.003) and hospital stay (p < 0.001). Conclusion: In percutaneously tracheostomized patients with prolonged weaning, the use of a TR seems to facilitate and improve the weaning process considerably. The duration of spontaneous breathing prior to decannulation, age and oxygenation describe the risk for recannulation in these patients. Copyright (c) 2012 S. Karger AG, Basel

Background: For several immune-mediated diseases, immunological analysis will become more complex in the future with datasets in which cytokine and gene expression data play a major role. These data have certain characteristics that require sophisticated statistical analysis such as strategies for non-normal distribution and censoring. Additionally, complex and multiple immunological relationships need to be adjusted for potential confounding and interaction effects. Objective: We aimed to introduce and apply different methods for statistical analysis of non-normal censored cytokine and gene expression data. Furthermore, we assessed the performance and accuracy of a novel regression approach in order to allow adjusting for covariates and potential confounding. Methods: For non-normally distributed censored data traditional means such as the Kaplan-Meier method or the generalized Wilcoxon test are described. In order to adjust for covariates the novel approach named Tobit regression on ranks was introduced. Its performance and accuracy for analysis of non-normal censored cytokine/gene expression data was evaluated by a simulation study and a statistical experiment applying permutation and bootstrapping. Results: If adjustment for covariates is not necessary traditional statistical methods are adequate for non-normal censored data. Comparable with these and appropriate if additional adjustment is required, Tobit regression on ranks is a valid method. Its power, type-I error rate and accuracy were comparable to the classical Tobit regression. Conclusion: Non-normally distributed censored immunological data require appropriate statistical methods. Tobit regression on ranks meets these requirements and can be used for adjustment for covariates and potential confounding in large and complex immunological datasets.

Background: For experimental basic research, standardized transplantation models reflecting technical and immunologic aspects are necessary. This article describes an experimental model of combined pancreas/kidney transplantation (PKTx) in detail. Materials and Methods: Donor rats underwent en bloc pancreatectomy and nephrectomy. Revascularization was performed using the aorta with the superior mesenteric artery and the inferior vena cava with the portal vein. Exocrine drainage of the pancreas took place over a segment of the duodenum which was transplanted side-to-side to the jejunum. The kidney vessels were transplanted end-to-side. The ureter was anastomosed by patch technique. Postoperatively, serum parameters were monitored daily. Biopsies for histopathology were taken on days 5, 8 and 12. Results: All 12 recipients survived the combined PKTx without serious surgical complications. One thrombosis of the portal vein led to organ failure. Blood glucose levels were normal by the 3rd postoperative day. The transplanted duodenal segment showed slight villous atrophy, and the kidneys were well perfused without vascular complications. The anastomosis between ureter and bladder was leakproof. Conclusions: Excellent graft function and survival rates can be achieved due to simplified operation technique and short operation time. It may thus have high clinical relevance to immunologic issues within the scope of basic research. Copyright (C) 2009 S. Karger AG, Basel

Background: For the last eight years, microarray-based classification has been a major topic in statistics, bioinformatics and biomedicine research. Traditional methods often yield unsatisfactory results or may even be inapplicable in the so-called "p >> n" setting where the number of predictors p by far exceeds the number of observations n, hence the term "ill-posed-problem". Careful model selection and evaluation satisfying accepted good-practice standards is a very complex task for statisticians without experience in this area or for scientists with limited statistical background. The multiplicity of available methods for class prediction based on high-dimensional data is an additional practical challenge for inexperienced researchers. Results: In this article, we introduce a new Bioconductor package called CMA (standing for "Classification for MicroArrays") for automatically performing variable selection, parameter tuning, classifier construction, and unbiased evaluation of the constructed classifiers using a large number of usual methods. Without much time and effort, users are provided with an overview of the unbiased accuracy of most top-performing classifiers. Furthermore, the standardized evaluation framework underlying CMA can also be beneficial in statistical research for comparison purposes, for instance if a new classifier has to be compared to existing approaches. Conclusion: CMA is a user-friendly comprehensive package for classifier construction and evaluation implementing most usual approaches. It is freely available from the Bioconductor website at http://bioconductor.org/packages/2.3/bioc/html/CMA.html.

Background: For optimal T cell activation it is desirable that dendritic cells (DCs) display peptides within MHC molecules as signal 1, costimulatory molecules as signal 2 and, in addition, produce IL-12p70 as signal 3. IL-12p70 polarizes T cell responses towards CD4(+) T helper 1 cells, which then support the development of CD8(+) cytotoxic T lymphocytes. We therefore developed new maturation cocktails allowing DCs to produce biologically active IL-12p70 for large-scale cancer vaccine development. Methods: After elutriation of leukapheresis products in a closed bag system, enriched monocytes were cultured with GM-CSF and IL-4 for six days to generate immature DCs that were then matured with cocktails, containing cytokines, interferon-gamma, prostaglandin E2, and a ligand for Toll-like receptor 8, with or without poly (I: C). Results: Mature DCs expressed appropriate maturation markers and the lymph node homing chemokine receptor, CCR7. They retained full maturity after culture for two days without maturation cocktails and following cryopreservation. TLR ligand stimulation induced DCs capable of secreting IL-12p70 in primary cultures and after one day of coculture with CD40L-expressing fibroblasts, mimicking an encounter with T cells. DCs matured with our new cocktails containing TLR8 ligand, with or without poly (I: C), induced alloresponses and stimulated virus-specific T cells after peptide-pulsing. DCs matured in cocktails containing TLR8 ligand without poly (I: C) could also be loaded with RNA as a source of antigen, whereas DCs matured in cocktails containing poly (I: C) were unable to express proteins following RNA transfer by electroporation. Conclusion: Our new maturation cocktails allowed easy DC harvesting, stable maturation and substantial recoveries of mature DCs after cryopreservation. Our procedure for generating DCs is easily adaptable for GMP-compliance and yields IL-12p70-secreting DCs suitable for development of cancer vaccines using peptides or RNA as sources of immunizing antigens.

Background: For a diploid organism such as human, the two alleles of a particular gene can be expressed at different levels due to X chromosome inactivation, gene imprinting, different local promoter activity, or mRNA stability. Recently, imbalanced allelic expression was found to be common in human and can follow Mendelian inheritance. Here we present a method that employs real competitive PCR for allele-specific expression analysis. Results: A transcribed mutation such as a single nucleotide polymorphism ( SNP) is used as the marker for allele-specific expression analysis. A synthetic mutation created in the competitor is close to a natural mutation site in the cDNA sequence. PCR is used to amplify the two cDNA sequences from the two alleles and the competitor. A base extension reaction with a mixture of ddNTPs/ dNTP is used to generate three oligonucleotides for the two cDNAs and the competitor. The three products are identified and their ratios are calculated based on their peak areas in the MALDI-TOF mass spectrum. Several examples are given to illustrate how allele-specific gene expression can be applied in different biological studies. Conclusions: This technique can quantify the absolute expression level of each individual allele of a gene with high precision and throughput.