Podcasts about lmb

Llega el Paquete Económico con ajustes para 2026, los mexicanos usan cada vez más crédito y ahorros para mantener su consumo, y la producción petrolera de Pemex lejos de la meta, con Gonzalo Soto y Patricia Tapia.00:00 Introducción02:12 Más tijerazos; llega el Paquete Económico con ajustes para 202609:05 Mexicanos usan cada vez más crédito y ahorros para mantener su consumo12:54 Producción petrolera de Pemex lejos de la meta de 1.8 millones de barriles16:31 Ruido, la contaminación invisible en la CDMX que acumula denuncias y molestias19:45 El Centenario de la LMB enfrenta a la Cenicienta y el Emperador: Charros y Diablos, a la Serie del Rey 2025

Estados Unidos fue derrotado por Corea del Sur.  Los Diablos son bicampeonesnde la zona sur de la LMB y están en la Serie del Rey.

Pumas y Xolos ganaron en el último día de la jornada.Seattle Sounders nuevo campeón de la Leagues Cup.Continúan los playoffs de la LMB.

El ala cerrada de los Chiefs y la cantante hicieron oficial su compromiso en redes sociales.Algodoneros recorta distancia ante Charros en los playoffs de la LMB.Alexander Zverev pasó sin problemas a la segunda ronda del US Open.

Julián Araujo podría reforzar al Sevilla.Los Diablos Rojos aseguraron su lugar en la Serie de Campeonato de la Zona Sur de la LMB.

Pumas y Puebla aburrieron con empate a cero. Siguen las Series de Zona de la LMB. Diablos con 3 victorias.

Rayados es el nuevo líder general del Apertura 2025. Cruz Azul sigue invicto. Actividad en los playoffs de la LMB.

Acompáñanos en este programa en el que hablamos sobre el 100 aniversario de la Liga Mexicana de beisbol, sobre como van los playoffs y cada serie en la LMB

Los 4 equipos mexicanos jugarán los 4tos de final de la Leagues Cup. Barcelona Femenil jugará 2 partidos en México. Comienzan las series de zona de la LMB.

Gonzalo Piovi no saldrá de Cruz Azul.  Inician las series de zona de la LMB.

Acompáñanos en este programa en el que hablamos sobre el 100 aniversario de la Liga Mexicana de beisbol, sobre como van los playoffs y cada serie en la LMB

México jugará contra Ecuador en Guadalajara.  Continúa la actividad de los playoffs de la LMB.

We celebrate the “gravity” and the “magnitude” of the moment as Jen Pawol makes history as the first woman to umpire a regular season MLB game.  We also put it into the disappointing context that not only is MLB 28 years behind the NBA, but, as Chelsea James notes, we almost had robo-umps before a woman had the gig. Our continuing excellent taste in baseball boyfriends is reinforced as the Heart and Hustle winners are announced, with an 80% NCiB BF showing. The PCA report turns into a vocabulary lesson with Outs Above Average and 5-Star catches. Shea turns batting lead-off into a show and we discover a Correa/Caratini/childhood link. The NYY Old-Timers are looking a little weekend-warrior-ish but we appreciate the effort. Our crosstraining/police blotter/rant is over the dangerous and demeaning throwing of sex toys onto the court at WNBA games. Pottymouth checks in with some old friends in the LMB. And please bookmark this link to the PWHL/Tim Horton Barbie because Patti needs one for Christmas and this fantastic little fundraiser is currently sold out.We say “Hall-ish of Fame or Hall of Fame-ish?” “eye of the beardholder,” and “what's weirder? Me saying dildo or me saying meme coin?” Fight the man, send your game balls to Meredith, get boosted, and find us on Bluesky @ncibpodcast, on Facebook @nocryinginbball, Instagram @nocryinginbball and on the Interweb at nocryinginbball.com. Please take a moment to subscribe to the show, and leave us a review on Apple Podcasts or wherever you listen to NCiB. Become a supporter at Patreon to help us keep doing what we do. We now have episode transcripts available!  They are available for free at our Patreon site. Say goodnight, Pottymouth. 

Pachuca con paso perfecto.Arrancaron los playoffs de la LMB con victoria de Diablos Rojos del México.

Acompáñanos en este programa en el que hablamos sobre el 100 aniversario de la Liga Mexicana de beisbol, sobre como van el standing y juegos en la LMB

Los equipos mexicanos no están obteniendo resultados positivos en este torneo. Heung-Min Son recibió emotiva despedida en el Tottenham. Diablos Rojos del México siguen imparables en la LMB.

Acompáñanos en este programa en el que hablamos sobre el 100 aniversario de la Liga Mexicana de beisbol, sobre como van el standing y juegos en la LMB

Acompáñanos en este programa en el que hablamos sobre el 100 aniversario de la Liga Mexicana de beisbol, sobre como van el standing y juegos en la LMB

Acompáñanos en este programa en el que hablamos sobre el 100 aniversario de la Liga Mexicana de beisbol, sobre como van el standing y juegos en la LMB

Acompáñanos en este programa en el que hablamos sobre el 100 aniversario de la Liga Mexicana de beisbol, sobre como van el standing y juegos en la LMB

Palmeiras accedió a la siguiente ronda y el Porto está eliminado.Denis Bouanga es el objetivo del América en la delantera.Los Diablos ganaron 11-5 ante los Piratas de Campeche en la LMB.

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Esta suele ser la primera decisión importante que debes tomar al aprender WordPress. Curso WordPress orientado a usuarios Conocerás los aspectos generales de administración. Conceptos básicos: qué son páginas, entradas, menús, ajustes generales. SEO y posicionamiento básico de contenidos. Uso del editor por bloques (Gutenberg) a nivel básico. Curso WordPress orientado a profesionales autónomos Llevará tu aprendizaje más allá, entendiendo cómo funcionan los Custom Post Types (CPT), campos personalizados y consultas personalizadas. Conceptos claros sobre bases de datos, CSS básico y estructuras dinámicas. Atención especial a cómo ofrecer estos servicios a clientes y optimizar un flujo de trabajo profesional. ¿Qué recomiendo? Para empezar fuerte, recomiendo formarte como profesional aunque tu fin más inmediato sea gestionar tu propia web. Así tendrás un mayor dominio y libertad sobre tu proyecto y posteriores trabajos. Herramientas premium vs plugins gratuitos: ¿cuál usar en tu primer curso WordPress? Una de las mayores preguntas al aprender WordPress es ¿qué plugins usar? Aquí tienes las alternativas más potentes: Plugins Gratuitos (ACF, por ejemplo) Advanced Custom Fields (ACF) es la solución más conocida y popular. Su versión gratuita permite crear estos campos personalizados esenciales. Buen punto de entrada inicial al ecosistema avanzado de WordPress. La versión gratuita limita algunas cosas avanzadas, como filtros y consultas más complejas. Plugins Premium: JetEngine y la suite Crocoblock Crocoblock (que patrocina habitualmente Negocios y WordPress, nuestro podcast favorito), cuenta con herramientas premium potentes: JetEngine: ideal para gestionar CPT, queries avanzadas y campos personalizados de forma completa. JetSmartFilters: para crear filtros dinámicos potentes fáciles de usar. JetAppointment, JetBooking: ideales para sitios de reservas y citas. Si planeas dedicarte seriamente al desarrollo web profesional, aunque sea desde cero, invertir desde el principio en herramientas premium intuyo es la mejor opción. Acortarás la curva de aprendizaje y dominarás rápidamente herramientas que se emplean en el día a día profesional. Si empiezas con herramientas gratuitas, ACF es una apuesta segura, aunque tendrás limitaciones al hacer queries complejas, filtros dinámicos o personalizaciones muy específicas. Cómo funciona Site Editor (Editor del sitio) en WordPress En 2025, el Site Editor de WordPress (antiguo Full Site Editing) será esencial. Debes dominar: Plantillas personalizadas (Single, Archive, 404). Estilización global fácilmente accesible. Creación visual basada en bloques nativos de WordPress Gutenberg. Conócelos con detalle en WordPress.org Caso práctico: ¿aprendes creando tu propia web o la de un cliente? Otra decisión clave para tu curso de WordPress desde cero: Web Personal (tipo portfolio de freelancer) Pros: Puedes aprovechar a pensar de manera estratégica sobre tus propios servicios desde el minuto uno. Aplicar conocimientos de branding personal (método LMB de la Máquina del Branding, por ejemplo) desde el principio. Contras: Se pueden mezclar conceptos sobre estrategias de ventas y contenidos web con los propiamente técnicos del curso. Quizás pierdes objetividad y claridad conceptual. Web Cliente (restaurante, hotel, pyme) Pros: Se entienden mejor los conceptos universales (productos, cartas, citas/reservas) El proceso es más neutro y objetivo, simplificando la comprensión. Puedes replicar en otros clientes fácilmente las estructuras aprendidas. Contras: Pierdes oportunidad de reflexionar sobre tu propio negocio digital. Mi consejo: comienza con un ejemplo claro y entendible por cualquier audiencia. Un pequeño restaurante es fácilmente entendible por todos y permite entender conceptos universales claramente. El valor del contenido vertical (Shorts, Reels, TikTok) en tu aprendizaje WordPress Otra tendencia clave actual es el formato de vídeo vertical (Shorts, Reels, TikTok). ¿Es útil? Es atractivo para captar tu atención rápida sobre "qué puedes hacer con WordPress". Menos útil para explicar "cómo hacer" (tutorial paso a paso). Recomiendo utilizar estos formatos para aprender conceptos, trucos rápidos y consejos estratégicos breves. Ejemplos prácticos disponibles en TikTok, Shorts YouTube y Reels Instagram. Automatización, APIs y CRM/ERP avanzado para WordPress Finalmente, otro aspecto que todo webmaster y desarrollador profesional debería conocer para complementar WordPress es: Automatizaciones: configurar conexiones con Make, Zapier, Airtable, etc. Entender APIs (JSON, REST) para conectar con servicios externos. Gestionar el negocio del cliente con un CRM o ERP avanzado (por ejemplo, Airtable combinado con Square para ventas en tiendas físicas). Te recomiendo ver casos prácticos como el desarrollado en Cobardes y Gallinas, donde han aplicado todo un sistema ERP construido alrededor del ecosistema no-code como Airtable y Square. Preguntas Frecuentes sobre aprender WordPress desde cero ¿Qué necesito para empezar a aprender WordPress en 2025? Solo necesitas: Instalación local o web con WordPress. Ganas de aprender: aprovecha herramientas como JetEngine o ACF para estructuras dinámicas. ¿Debo usar plugins premium al empezar a aprender? Recomendado si quieres profesionalizarte rápidamente. Si solo deseas explorar gratis, comienza con opciones gratis (ACF) y luego invierte en premium una vez domines lo básico. Conclusión final: tu ruta estratégica para aprender WordPress en 2025 Para obtener el máximo rendimiento y estabilidad a largo plazo, piensa desde hoy en las necesidades profesionales que tarde o temprano surgirán en tu camino WordPress: Aprende Site Editor y conceptos universales de bases de datos personalizadas. Decántate por plugins premium si ves claramente tu futuro en desarrollo web profesional. Usa ejemplos prácticos neutros inicialmente (web de negocio-pyme). Combina contenidos largos con píldoras rápidas en formato vertical ideando una estrategia completa. Ahora, deja en los comentarios cuál es tu situación actual con WordPress: ¿acabas de empezar? ¿qué dudas o necesidades específicas tienes para tu perfil? ¡Quiero leerte e interactuar contigo en profundidad!

Acompáñanos en este programa en el que hablamos sobre el 100 aniversario de la Liga Mexicana de beisbol, sobre como van el standing y juegos en la LMB

Está tarde Toño de Valdés y Enrique Burak hablaremos del cambio de Rafael Devers de Boston a San Francisco, Adams de lo que significa este movimiento en las grandes ligas. Se acerca el final de la finales de la NBA y todo sobre la enfermedad de Jason Kelce.

Acompáñanos en este programa en el que hablamos sobre el 100 aniversario de la Liga Mexicana de beisbol, sobre como van el standing y juegos en la LMB

Acompáñanos en este programa en el que hablamos sobre el 100 aniversario de la Liga Mexicana de beisbol, sobre como van el standing y juegos en la LMB

Audio FileGround Truths can also be found on Apple Podcasts, Spotify and YouTube.The UK is the world leader in human genomics, and laid the foundation for advancing medicine with the UK Biobank, Genomes England and now Our Future Health (w/ 5 million participants). Sir John Bell is a major force in driving and advising these and many other initiatives. After 22 years as the Regius Professor of Medicine at the University of Oxford he left in 2024 to be President of the Ellison Institute of Technology. Professor Bell has been duly recognized in the UK: knighted in 2015 and appointed Companion of Honor in 2023. In our conversation, you will get a sense for how EIT will be transformational for using A.I. and life science for promoting human health.Transcript with audio links Eric Topol (00:06):Hello, this is Eric Topol from Ground Truths. And I'm really delighted to welcome today, Sir John Bell who had an extraordinary career as a geneticist, immunologist, we'll talk about several initiatives he's been involved with during his long tenure at University of Oxford, recently became head of the Ellison Institute of Technology (EIT) in the UK. So welcome, John.Sir John Bell (00:30):Thanks, Eric. Thanks very much for having me.Eric Topol (00:34):Well, I think it's just extraordinary the contributions that you have made and continue to make to advance medicine, and I thought what we could do is get into that. I mean, what's interesting, you have had some notable migrations over your career, I think starting in Canada, at Stanford, then over as Rhodes Scholar in Oxford. And then you of course had a couple of decades in a very prestigious position, which as I understand was started in 1546 by King Henry VII, and served as the Regius Professor of Medicine at the University of Oxford. Do I have that right?Sir John Bell (01:11):It was actually Henry VIII, but you were close.Eric Topol (01:14):Henry VIII, that's great. Yeah. Okay, good. Well, that's a pretty notable professorship. And then of course in recent times you left to head up this pretty formidable new institute, which is something that's a big trend going on around the world, particularly in the US and we'll talk about. So maybe we can start with the new thing. Tell us more about the Ellison Institute of Technology (EIT), if you will.Sir John Bell (01:47):Yeah. So as you know, Larry Ellison has been one of the great tech entrepreneurs focused really on developing terrific databases over his career and through Oracle, which is the company that he founded. And Larry is really keen to try and give back something substantial to the world, which is based on science and technology. So he and I did quite a bit together over the Covid pandemic. He and I talked a lot about what we're doing and so on. He came to visit afterwards and he had, I think he decided that the right way to make his contributions would be to set up an institute that would be using the state-of-the-art science and technology with a lot of AI and machine learning, but also some of the other modern tools to address the major problems in healthcare, in food security, in green energy and climate change and in global governance.Sir John Bell (02:49):So anyway, he launched this about 18 months ago. He approached me to ask whether I would run it. He wanted to set it up outside Oxford, and he wanted to do something which is a bit different than others. And that is his view was that we needed to try and create solutions to these problems which are commercially viable and not all the solutions are going to be commercially viable, but where you can create those, you make them sustainable. So the idea is to make sure that we create solutions that people want to buy, and then if they buy them, you can create a sustainable solution to those issues. So we are actually a company, but we are addressing many of the same problems that the big foundations are addressing. And the big issues that you and I talk about in health, for example, are all on our list. So we're kind of optimistic as to where this will go and Larry's supporting the project and we're going to build out an institute here which will have about 5,000 people in it, and we'll be, I think a pretty exciting new addition to the science and technology ecosystem globally.Eric Topol (04:02):Well, I know the reverberations and the excitement is palpable and some of the colleagues I've spoken to, not just in England, but of course all over the world. So congratulations on that. It was a big move for you to leave the hardcore academics. And the other thing I wanted to ask you, John, is you had distinguished your career in immunology, in genetics, type 1 diabetes and other conditions, autoimmune conditions, and now you've really diversified, as you described with these different areas of emphasis at the new institute. Is that more fun to do it or do you have deputies that you can assign to things like climate change in other areas?Sir John Bell (04:50):Trust me, Eric, I'm not making any definitive decisions about areas I know nothing about, but part of this is about how do you set up leadership, run a team, get the right people in. And I have to say one of the really interesting things about the institute is we've been able to recruit some outstanding people across all those domains. And as you know, success is almost all dependent on people. So we're really pretty optimistic we're going to have a significant impact. And of course, we also want to take risks because not a lot of point in us doing stuff that everybody else is doing. So we're going to be doing some things that are pretty way out there and some of them will fail, so we are just going to get used to trying to make sure we get a few of them across the finish line. But the other thing is that, and you've experienced this too, you never get too old to learn. I mean, I'm sucking up stuff that I never thought I would ever learn about, which is fun actually, and really marvel.Eric Topol (05:55):It's fantastic. I mean, you've really broadened and it's great that you have the runway to get these people on board and I think you're having a big building that's under construction?Sir John Bell (06:07):Yeah, we've got the original building that Larry committed to is about 330,000 square feet of space. I mean, this is completely amazing, but we are of course to accommodate up to 5,000 people, we're going to need more than that. So we are looking at a much wider campus here that'll involve more than just that building. I think we'll end up with several million square feet of space by the time we're finished. So mean, it's a really big project, but we've already made progress in some domains to try and get projects and the beginnings of companies on the road to try and solve some of the big problems. So we're quite excited about it.Eric Topol (06:49):Now you, I assume it's pretty close to Oxford, and will you have some kind of inter interactions that are substantial?Sir John Bell (06:58):Yeah, so the university's been terrific about this actually, because of course most universities would say, well, why don't you do it inside the university and just give us the money and it'll all be fine. So of course Larry. Larry wasn't born yesterday, so I said, well, thank you very much, but I think we'll probably do this nearby. But the university also realized this is a really exciting opportunity for them and we've got a really good relationship with them. We've signed an agreement with them as to who will work where. We've agreed not to steal a lot of their staff. We're going to be bringing new people into the ecosystem. Some of the university people will spend some time with us and sometime in the university, so that will help. But we're also bringing quite a few new people into the setting. So the university has been really positive. And I think one of the things that's attractive to the university, and you'll be familiar with this problem in the UK, is that we're quite good. The discovery science here is pretty good.Sir John Bell (08:06):And we do startups now at scale. So Oxford does lots of little startup companies in the biotech space and all the rest of it, but we never scale any of these companies because there isn't the depth of capital for scaling capital to get these things scaled. And so, in a way what we're trying to do here at Ellison actually avoids that problem because Larry knows how to scale companies, and we've got the financial support now. If we have things that are really successful, we can build the full stack solution to some of these problems. So I think the university is really intrigued as to how we might do that. We're going to have to bring some people in that know how to do that and build billion dollar companies, but it's sufficiently attractive. We've already started to recruit some really outstanding people. So as a way to change the UK system broadly, it's actually quite a good disruptive influence on the way the thing works to try and fix some of the fundamental problems.Eric Topol (09:07):I love that model and the ability that you can go from small startups to really transformative companies have any impact. It fits in well with the overall objectives, I can see that. The thing that also is intriguing regarding this whole effort is that in parallel we've learned your influence. The UK is a genomics world leader without any question and no coincidence that that's been your area of emphasis in your career. So we've watched these three initiatives that I think you were involved in the UK Biobank, which has had more impact than any cohort ever assembled. Every day there's another paper using that data that's coming out. There's Genomes England, and then now Our Future Health, which a lot of people don't know about here, which is well into the 5 million people enrollment. Can you tell us about, this is now 15 years ago plus when these were started, and of course now with a new one that's the biggest ever. What was your thinking and involvement and how you built the UK to be a world leader in this space?Sir John Bell (10:26):So if you turn the clock back 20 years, or actually slightly more than 25 years ago, it was clear that genomics was going to have a play. And I think many of us believed that there was going to be a genetic element to most of the major common disease turn out to be true. But at the time, there were a few skeptics, but it seemed to us that there was going to be a genetic story that underpinned an awful lot of human disease and medicine. And we were fortunate because in Oxford as you know, one of my predecessors in the Regius job was Richard Doll, and he built up this fantastic epidemiology capability in Oxford around Richard Peto, Rory Collins, and those folks, and they really knew how to do large scale epidemiology. And one of the things that they'd observed, which is it turns out to be true with genetics as well, is a lot of the effects are relatively small, but they're still quite significant. So you do need large scale cohorts to understand what you're doing. And it was really Richard that pioneered the whole thinking behind that. So when we had another element in the formula, which was the ability to detect genetic variation and put that into the formula, it seemed to me that we could move into an era where you could set up, again, large cohorts, but build into the ability to have DNA, interrogate the DNA, and also ultimately interrogate things like proteomics and metabolomics, which were just in their infancy at that stage.Sir John Bell (12:04):Very early on I got together because I was at that stage at the Nuffield Chair of Medicine, and I got together, Rory and Richard and a couple of others, and we talked a little bit about what it would look like, and we agreed that a half a million people late to middle age, 45 and above would probably over time when you did the power calculations, give you a pretty good insight in most of the major diseases. And then it was really a question of collecting them and storing the samples. So in order to get it funded at the time I was on the council of the MRC and George Radda, who you may remember, was quite a distinguished NMR physiologist here. He was the chief executive of the MRC. So I approached him and I said, look, George, this would be a great thing for us to do in the UK because we have all the clinical records of these people going back for a decade, and will continue to do that.Sir John Bell (13:01):Of course, we immediately sent it out to a peer review committee in the MRC who completely trashed the idea and said, you got to be joking. So I thought, okay, that's how that lasted. And I did say to George, I said, that must mean this is a really good idea because if it had gone straight through peer review, you would've known you were toast. So anyway, I think we had one more swing at peer review and decided in the end that wasn't going to work. In the end, George to his credit, took it to MRC council and we pitched it and everybody thought, what a great idea, let's just get on and do it. And then the Wellcome came in. Mark Walport was at the Wellcome at the time, great guy, and did a really good job at bringing the Wellcome on board.Sir John Bell (13:45):And people forget the quantum of money we had to do this at the time was about 60 million pounds. I mean, it wasn't astonishly small. And then of course we had a couple of wise people who came in to give us advice, and the first thing they said, well, if you ever thought you were really going to be able to do genetics on 500,000 people, forget it. That'll never work. So I thought, okay, I'll just mark that one out. And then they said, and by the way, you shouldn't assume you can get any data from the health service because you'll never be able to collect clinical data on any of these people. So I said, yeah, yeah, okay, I get it. Just give us the money and let us get on. So anyway, it's quite an interesting story. It does show how conservative the community actually is for new ideas.Sir John Bell (14:39):Then I chaired the first science committee, and we decided about a year into it that we really needed the chief executive. So we got Rory Collins to lead it and done it. I sat on the board then for the next 10 years, but well look, it was a great success. And as you say, it is kind of the paradigm for now, large genetic epidemiology cohorts. So then, as you know, I advise government for many years, and David Cameron had just been elected as Prime Minister. This was in about 2010. And at the time I'd been tracking because we had quite a strong genomics program in the Wellcome Trust center, which I'd set up in the university, and we were really interested in the genetics of common disease. It became clear that the price of sequencing and Illumina was now the clear leader in the sequencing space.Sir John Bell (15:39):But it was also clear that Illumina was making significant advances in the price of sequencing because as you remember, the days when it cost $5,000 to do a genome. Anyway, it became clear that they actually had technology that gets you down to a much more sensible price, something like $500 a genome. So I approached David and I said, we are now pretty sure that for many of the rare diseases that you see in clinical practice, there is a genetic answer that can be detected if you sequenced a whole genome. So why don't we set something up in the NHS to provide what was essentially the beginnings of a clinical service to help the parents of kids with various disabilities work out what's going on, what's wrong with their children. And David had had a child with Ohtahara syndrome, which as you know is again, and so David was very, he said, oh God, I'll tell you the story about how awful it was for me and for my wife Samantha.Sir John Bell (16:41):And nobody could tell us anything about what was going on, and we weren't looking for a cure, but it would've really helped if somebody said, we know what it is, we know what the cause is, we'll chip away and maybe there will be something we can do, but at least you know the answer. So anyway, he gave us very strong support and said to the NHS, can you please get on and do it? Again massive resistance, Eric as you can imagine, all the clinical geneticists said, oh my God, what are they doing? It's complete disaster, dah, dah, dah. So anyway, we put on our tin hats and went out and got the thing going. And again, they did a really good job. They got to, their idea was to get a hundred thousand genomes done in a reasonable timeframe. I think five years we set ourselves and the technology advance, people often underestimate the parallel development of technology, which is always going on. And so, that really enabled us to get that done, and it still continues. They're doing a big neonatal program at the moment, which is really exciting. And then I was asked by Theresa May to build a life science strategy because the UK, we do this stuff not as big and broad as America, but for a small country we do life sciences pretty well.Eric Topol (18:02):That's an understatement, by the way. A big understatement.Sir John Bell (18:04):Anyway, so I wrote the strategies in 2017 for Theresa about what we would do as a nation to support life sciences. And it was interesting because I brought a group of pharma companies together to say, look, this is for you guys, so tell us what you want done. We had a series of meetings and what became clear is that they were really interested in where healthcare was going to end up in the next 20 years. And they said, you guys should try and get ahead of that wave. And so, we agreed that one of the domains that really hadn't been explored properly, it was the whole concept of prevention.Sir John Bell (18:45):Early diagnosis and prevention, which they were smart enough to realize that the kind of current paradigm of treating everybody in the last six months of life, you can make money doing that, there's no doubt, but it doesn't really fix the problem. And so, they said, look, we would love it if you created a cohort from the age of 18 that was big enough that we could actually track the trajectories of people with these diseases, identify them at a presymptomatic stage, intervene with preventative therapies, diagnose diseases earlier, and see if we could fundamentally change the whole approach to public health. So we anyway, went back and did the numbers because of course at much wider age group, a lot of people don't get at all sick, but we thought if we collected 5 million people, we would probably have enough. That's 10% of the UK adult population.Sir John Bell (19:37):So anyway, amazingly the government said, off you go. We then had Covid, which as you know, kept you and I busy for a few years before we could get back to it. But then we got at it, and we hired a great guy who had done a bit of this in the UAE, and he came across and we set up a population health recruitment structure, which was community-based. And we rapidly started to recruit people. So we've now got 2.9 million people registered, 2.3 million people consented, and we've got blood in the bank and all the necessary data including questionnaire data for 1.5 million people growing up. So we will get to 5 million and it's amazing.Eric Topol (20:29):It is. It really is, and I'm just blown away by the progress you've made. And what was interesting too, besides you all weren't complacent about, oh, we got this UK Biobank and you just kept forging ahead. And by the way, I really share this importance of finally what has been a fantasy of primary prevention, which never really achieved. It's always, oh, after a heart attack. But that's what I wrote about in the Super Agers book, and I'll get you a copy.Sir John Bell (21:02):No, I know you're a passionate believer in this and we need to do a lot of things. So we need to work out what's the trial protocol for primary prevention. We need to get the regulators on board. We've got to get them to understand that we need diagnostics that define risk, not disease, because that's going to be a key bit of what we're going to try and do. And we need to understand that for a lot of these diseases, you have to intervene quite early to flatten that morbidity curve.Eric Topol (21:32):Yeah, absolutely. What we've learned, for example, from the UK Biobank is not just, of course the genomics that you touched on, but the proteomics, the organ clocks and all these other layers of data. So that gets me to my next topic, which I know you're all over it, which is AI.Eric Topol (21:51):So when I did the NHS review back in 2018, 2019, the group of people which were amazing that I had to work with no doubt why the UK punches well beyond its weight. I had about 50 people, and they just said, you know what? Yeah, we are the world leaders in genomics. We want to be the world leader in AI. Now these days you only hear about US and China, which is ridiculous. And you have perhaps one of the, I would say most formidable groups there with Demis and Google DeepMind, it's just extraordinary. So all the things that the main foci of the Ellison Institute intersect with AI.Sir John Bell (22:36):They do. And we, we've got two underpinning platforms, well actually three underpinning platforms that go across all those domains. Larry was really keen that we became a real leader in AI. So he's funded that with a massive compute capacity. And remember, most universities these days have a hard time competing on compute because it's expensive.Eric Topol (22:57):Oh yeah.Sir John Bell (22:58):So that is a real advantage to us. He's also funded a great team. We've recruited some people from Demis's shop who are obviously outstanding, but also others from around Europe. So we really, we've recruited now about 15 really outstanding machine learning and AI people. And of course, we're now thinking about the other asset that the UK has got, and particularly in the healthcare space is data. So we do have some really unique data sets because those are the three bits of this that you need if you're going to make this work. So we're pretty excited about that as an underpinning bit of the whole Ellison Institute strategy is to fundamentally underpin it with very strong AI. Then the second platform is generative biology or synthetic biology, because this is a field which is sort of, I hesitate to say limped along, but it's lacked a real focus.Sir John Bell (23:59):But we've been able to recruit Jason Chin from the LMB in Cambridge, and he is one of the real dramatic innovators in that space. And we see there's a real opportunity now to synthesize large bits of DNA, introduce them into cells, microbes, use it for a whole variety of different purposes, try and transform plants at a level that people haven't done before. So with AI and synthetic biology, we think we can feed all the main domains above us, and that's another exciting concept to what we're trying to do. But your report on AI was a bit of a turning point for the UK because you did point out to us that we did have a massive opportunity if we got our skates, and we do have talent, but you can't just do it with talent these days, you need compute, and you need data. So we're trying to assemble those things. So we think we'll be a big addition to that globally, hopefully.Eric Topol (25:00):Yeah. Well that's another reason why I am so excited to talk to you and know more about this Ellison Institute just because it's unique. I mean, there are other institutes as like Chan Zuckerberg, the Arc Institute. This is kind of a worldwide trend that we're seeing where great philanthropy investments are being seen outside of government, but none have the computing resources that are being made available nor the ability to recruit the AI scientists that'll help drive this forward. Now, the last topic I want to get into with you today is one that is where you're really grounded in, and that's the immune response.Eric Topol (25:43):So it's pretty darn clear now that, well, in medicine we have nothing. We have the white cell neutrophil to lymphocyte ratio, what a joke. And then on the other hand, we can do T and B cell sequencing repertoires, and we can do all this stuff, autoantibody screens, and the list goes on and on. How are we ever going to make a big dent in health where we know the immune system is such a vital part of this without the ability to check one's immune status at any point in time in a comprehensive way? What are your thoughts about that?Sir John Bell (26:21):Yeah, so you seem to be reading my mind there. We need to recruit you over here because I mean, this is exactly, this is one of our big projects that we've got that we're leaning into, and that is that, and we all experienced in Covid the ins and outs of vaccines, what works, what doesn't work. But what very clear is that we don't really know anything about vaccines. We basically, you put something together and you hope the trial works, you've got no intermediate steps. So we're building a really substantial immunophenotyping capability that will start to interrogate the different arms of the immune response at a molecular level so that we can use a combination of human challenge models. So we've got a big human challenge model facility here, use human challenge models with pathogens and with associated vaccines to try and interrogate which bits of the immune response are responsible for protection or therapy of particular immunologically mediated diseases or infectious diseases.Sir John Bell (27:30):And a crucial bit to that. And one of the reasons people have tried this before, but first of all, the depth at which you can interrogate the immune system has changed a lot recently, you can get a lot more data. But secondly, this is again, where the AI becomes important because it isn't going to be a simple, oh, it's the T-cell, it's going to be, well, it's a bit of the T cells, but it's also a bit of the innate immune response and don't forget mate cells and don't forget a bit of this and that. So we think that if we can assemble the right data set from these structured environments, we can start to predict and anticipate which type of immune response you need to stimulate both for therapy and for protection against disease. And hopefully that will actually create a whole scientific foundation for vaccine development, but also other kinds of immune therapy and things like cancer and potentially autoimmune disease as well. So that's a big push for us. We're just busy. The lab isn't set up. We've got somebody to run the lab now. We've got the human challenge model set up with Andy Pollard and colleagues. So we're building that out. And within six months, I think we'll be starting to collect data. So I'm just kind of hoping we can get the immune system in a bit more structured, because you're absolutely right. It's a bit pin the tail on the donkey at the moment. You have no idea what's actually causing what.Eric Topol (29:02):Yeah. Well, I didn't know about your efforts there, and I applaud that because it seems to me the big miss, the hole and the whole story about how we're going to advanced human health and with the recent breakthroughs in lupus and these various autoimmune diseases by just targeting CD19 B cells and resetting like a Ctrl-Alt-Delete of their immune system.Sir John Bell (29:27):No, it's amazing. And you wouldn't have predicted a lot of this stuff. I think that means that we haven't really got under the skin of the mechanistic events here, and we need to do more to try and get there, but there's steady advance in this field. So I'm pretty optimistic we'll make some headway in this space over the course of the next few years. So we're really excited about that. It's an important piece of the puzzle.Eric Topol (29:53):Yeah. Well, I am really impressed that you got all the bases covered here, and what a really exhilarating chance to kind of peek at what you're doing there. And we're going to be following it. I know I'm going to be following it very closely because I know all the other things that you've been involved with in your colleagues, big impact stuff. You don't take the little swings here. The last thing, maybe to get your comment, we're in a state of profound disruption here where science is getting gutted by a madman and his henchmen, whatever you want to call it, which is really obviously a very serious state. I'm hoping this is a short term hit, but worried that this will have a long, perhaps profound. Any words of encouragement that we're going to get through this from the other side of the pond?Sir John Bell (30:52):Well, I think regardless of the tariffs, the scientific community are a global community. And I think we need to remember that because our mission is a global mission, and we need to lean into that together. First of all, America is such a powerhouse of everything that's been done scientifically in the human health domain. But not only that, but across all the other domains that we work in, we can't really make the kind of progress that we need to without America being part of the agenda. So first of all, a lot of sympathy for you and your colleagues. I know it must be massively destabilizing for you, not be confident that the things that work are there to help you. But I'm pretty confident that this will settle down. Most of the science is for, well, all the science is really for public good, and I think the public recognizes it and they'll notice if it's not being prosecuted in the way that it has to be. And the global science community cannot survive without you. So we're all leaning in behind you, and I hope it will settle. One of my worries is that these things take years to set up and literally hours or minutes to destroy. So we can't afford to take years to set them back up again. So we do need to be a bit careful about that, but I still have huge confidence in what you guys can achieve and we're all behind you.Eric Topol (32:37):Well, that's really helpful getting some words of wisdom from you there, John. So this has been terrific. Thanks so much for joining, getting your perspective on what you're doing, what's important is so essential. And we'll stay tuned for sure.Sir John Bell (32:59):And come and visit us at the EIT, Eric. We'd be glad to see you.*******************************Some of the topics that John and I discussed—immunology, A.I., genomics, and prevention—are emphasized in my new book SUPER AGERS. A quick update: It will have a new cover after making the New York Times Bestseller list and is currently ranked #25 for all books on Amazon. Thanks to so many of you for supporting the book!Here are a few recent podcasts:Dax Shepard: Dr. Mike Sanjay Gupta ***********************Thanks for reading and subscribing to Ground Truths.If you found this interesting please share it!That makes the work involved in putting these together especially worthwhile.All content on Ground Truths— newsletters, analyses, and podcasts—is free, open-access.Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don't hesitate to post comments and give me feedback. Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. Get full access to Ground Truths at erictopol.substack.com/subscribe

Acompáñanos en este programa en el que hablamos sobre el 100 aniversario de la Liga Mexicana de beisbol, sobre como van el standing y juegos en la LMB

Acompáñanos en este programa en el que hablamos sobre el 100 aniversario de la Liga Mexicana de beisbol, sobre como van el standing y juegos en la LMB

Acompáñanos en este programa en el que hablamos sobre el 100 aniversario de la Liga Mexicana de beisbol, sobre como van el standing y juegos en la LMB

Acompáñanos en este programa en el que hablamos sobre el 100 aniversario de la Liga Mexicana de beisbol, sobre como van el standing y juegos en la LMB

En este episodio platicamos sobre el Draft de NFL, la rivalidad Diablos Tigres en los 100 años de la LMB y más.

En Italia los partidos regresan y en la Copa habrá un Derby entre Inter y Milán. Real Madrid recupera a Kylian Mbappe. Diablos Rojos del México se llevan la Guerra Civil de la LMB.

Friend, this topic is SO important I'm putting it back in front of you again. Here's the deal: Even people in strong, satisfying relationships can develop feelings of attraction for another person. It's part of the human experience. These feelings can be transient and meaningless... OR they could destroy your life, if you follow them.  Are crushes innocent, or on-ramps to an affair? Can you be "friends" with someone you have a crush on, without risking your relationship? What should you do when you're married, but have a crush on someone else? Oh, the questions! It happens: people in happy, healthy, committed relationships can still develop crushes on others. However, smart, self-aware people in committed relationships that they care about need to handle these maturely and with wisdom. That's what you'll learn how to do on today's show. We'll discuss:  The mechanics of a crush; how and why crushes develop The difference between a crush and a platonic friendship Why happy, committed married people can have crushes on others How crushes can turn into something more serious How to use self awareness, integrity, and honesty to protect your marriage How to use your crush experience in order to add energy and intimacy into your relationship Warning signs that your crush is developing into something else Why extramarital affairs are always a bad idea, and rarely end well How to stop having a crush on someone else How to avoid embarrassment and professional ruin if you have a crush on a coworker How to protect your relationship and stay true to your values even when you're having feelings for another. All this and more on today's episode of the Love, Happiness and Success Podcast. xoxo, Dr. Lisa Marie Bobby GrowingSelf.com Ps: As we discussed in this episode, part of your action plan needs to be leaning towards your partner in an authentic and emotionally intimate way, and that calls for excellent communication skills. To support you in this, please help yourself to my free two part communication skills training, "Communication That Connects." I made this for you!  ... LMB

El presidente saliente de los Olmecas de Tabasco, Gonzalo Medina González, resume su gestión al frente del equipo. ¿Se va satisfecho? ¿Cuáles fueron sus principales logros y sus momentos de crisis más significativos? Afirma que por logros, la franquicia vale 3 ó 4 veces más, que cuando lo asumió. Habla de las finanzas que heredará, incluidos 14 mdp en patrocinios firmados para 4 años. Ventila que a partir de octubre, participará como coordinador de festejos de los 100 años de la LMB.

En LMB siempre grabamos con escaladores con los que conectamos, y con Roberto esto fue muy fácil. Rápidamente nos dimos cuenta que Roberto trae un cotorreo elevado, sus ganas por escalar se desbordan, la pasión que le tiene a al escalada creemos que es inspiradora y probablemente su trabajo llegará muy lejos en los próximos años. Escucha a Roberto contarnos acerca de sus proyectos, zonas a desarrollar, motivación, personas con las que ha colaborados, marcas que lo apoyan y más. Este episodio viene cargado de bastantes saludos a personas que de alguna manera han inspirado o ayudado a LMB. Gracias!

Are Gen X Parents Ruining Retirement by Supporting Their Adult Children?In this episode, Dr. Preston Cherry delves into the critical issue of whether Gen X parents are jeopardizing their own retirement by financially supporting their adult children.By providing practical advice and discussing expert data, he equips parents with the tools to make informed decisions and set healthy financial boundaries.Want to learn more? Connect with us below! Dr. Preston D. Cherry on LinkedIn: https://www.linkedin.com/in/drprestoncherry/Dr. Preston D. Cherry's Website: https://www.drprestoncherry.com/Get your free wealth assessment! Visit our website for more insights and personalized guidance. Click here to go to our website: https://concurrentfp.com

In this episode, Dr. Preston D. Cherry delves into the intricacies of moving your 401k after leaving your job, featuring expert insights from Dr. Philip Gibson, a seasoned wealth advisor and chief compliance officer at Concurrent Financial Planning.Together, they explore both direct and indirect transfers of employer-sponsored plans, providing clarity on the 60-day rule and the potential 20% tax hit if funds are not moved accordingly.Want to learn more? Connect with us below! Dr. Preston D. Cherry on LinkedInDr. Preston D. Cherry's WebsiteDr. Philip Gibson on LinkedInGet your free wealth assessment! Visit our website for more insights and personalized guidance. Click here to go to our website: https://concurrentfp.com

Listen on your favorite podcast service: https://pods.to/wesoundcrazy Stream songs from the episode on our official We Sound Crazy playlists: https://lnkfi.re/8I8Drkfz This week, we're thrilled to have the multi-talented Avery*Sunshine as our special guest. With hits like “Call My Name” and “With You,” Avery has captivated audiences worldwide, earning critical acclaim and a loyal fan base. Her music, celebrated for its blend of soul, gospel, and R&B, has received praise from critics and peers alike, showcasing her extraordinary vocal talent and genuine artistry. And to top it off, she truly is a burst of sunshine! Join the We Sound Crazy crew for a truly great episode with the one and only, Avery*Sunshine. Don't wait, press play now! Hey, We Sound Crazy listeners! We're thrilled to share a special treat from the incredible Avery*Sunshine! To celebrate her recent episode on our podcast, Avery is offering an exclusive discount on her Lou*Mack Beauty beauty product line just for you! Use Code: SUNSHINEWEIRDOS for 25% OFF your entire purchase! Don't miss out on this chance to pamper yourself with Avery's luxurious beauty products. From radiant skincare to must-have cosmetics, LMB has everything you need to shine bright and feel fabulous! We Sound Crazy is your backstage pass to all things music and culture. Special thanks to our We Sound Crazy team! Director: Aaron Walton Camera Op: Tiffany Young, Aaron Walton Editing: Lamont Baldwin Producer: Michael "Roux" Johnson Assistant: Brittany Guydon PA: Bryan Bell, Aaron Walden Thank you to all of our listeners, as well as our partners at Visit Music City.   Special thanks to Avery*Sunshine! Subscribe to We Sound Crazy on Spotify, Apple Podcasts, and anywhere you get your favorite podcast.  Follow us on Twitter, Instagram, Facebook, YouTube, and TikTok! Follow We Sound Crazy on Social Media: ~ Facebook: https://wesoundcrazy.ffm.to/wscfacebook ~ Instagram: https://wesoundcrazy.ffm.to/wscinstagram ~ Twitter: https://wesoundcrazy.ffm.to/wsctwitter ~ TikTok: https://wesoundcrazy.ffm.to/wsctiktok ~ Email: https://ffm.link/wsc-signup Subscribe to We Sound Crazy on YouTube: https://wesoundcrazy.ffm.to/wscyoutube-subscribe Visit the official We Sound Crazy website: https://wesoundcrazy.ffm.to/officialwebsite #WeSoundCrazy #Avery*Sunshine Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode, Dr. Preston D. Cherry provides a comprehensive exploration into the world of luxury hotels, addressing the perennial question: Are luxury hotels worth it?  He delves into the critical alignment between personal finances and the value luxury accommodations bring to one's travel experience. Dr. Cherry offers clear and practical insights into the costs, benefits, and personal factors involved in choosing luxury accommodations.Want to learn more? Connect with us below! Dr. Preston D. Cherry on LinkedIn: https://www.linkedin.com/in/drprestoncherry/Dr. Preston D. Cherry's Website: https://www.drprestoncherry.com/Get your free wealth assessment! Visit our website for more insights and personalized guidance. Click here to go to our website: https://concurrentfp.com

In this episode, Dr. Preston D. Cherry breaks down the true meaning of wealth, going beyond the numbers. He sheds light on how understanding and managing wealth can improve our quality of life by aligning financial and personal goals. Listen in for practical advice and a realistic view on how to use your financial resources to thrive in all areas of life.Want to learn more? Connect with us below! Dr. Preston D. Cherry on LinkedInDr. Preston D. Cherry's WebsiteGet your free wealth assessment! Visit our website for more insights and personalized guidance. Click here to go to our website.

Join Dr. Preston D. Cherry and Dr. Renée Baker, as they dive deep into how aligning your life goals with smart financial planning can lead to true fulfillment. This episode is packed with valuable lessons on the importance of building strong relationships, being financially prepared, and keeping a growth mindset. Together, they inspire you to create a life where your dreams and finances thrive in perfect harmony.Want to learn more? Connect with us below! Dr. Renée Baker on LinkedIn.Dr. Renée Baker's WebsiteDr. Preston D. Cherry on LinkedIn Dr. Preston D. Cherry's Website Get your free wealth assessment! Visit our website for more insights and personalized guidance. Click here to go to our website.

Got a bonus check that feels smaller than expected? Don't worry, you're not alone! In this episode, Dr. Preston Cherry explores why bonus checks often feel like they're taxed more heavily than regular paychecks and shares practical strategies to mitigate the tax impact.Want to learn more? Connect with us below!Dr. Preston D. Cherry on LinkedIn.Dr. Preston D. Cherry's Website.Get your free wealth assessment! Visit our website for more insights and personalized guidance. Click here to go to our website.

Cristy es una escaladora llena de una energía contagiosa. Su habilidad para encadenar rutas duras es demasiado alta. La manera en la que nos describe sus mas recientes ascensos, viajes y estilo de vida, hacen de este episodio uno muy inspirador. Escucha a esta titana con cuerpo de acero en LMB. Seguramente te vas a motivar. --- Send in a voice message: https://podcasters.spotify.com/pod/show/la-mera-beta-podcast/message

Join Dr. Preston D. Cherry and Josh Brown, as they talk about the multifaceted relationship between wealth, spending habits, and time management. Through engaging anecdotes and practical advice, Dr. Cherry and Josh Brown encourage listeners to rethink their approach to wealth, time, and overall well-being.Want to learn more? Connect with us below! Josh Brown on LinkedIn.Dr. Preston D. Cherry on LinkedIn.Dr. Preston D. Cherry's Website.Get your free wealth assessment! Visit our website for more insights and personalized guidance. Click here to go to our website.

Join Dr. Preston D. Cherry and Danielle Miura, as they delve into the critical topic of long-term care conversations with loved ones. Plus, they break down the intricacies involved in navigating long-term care, from which topics to discuss to the financial implications of different care levels, such as in-home care and nursing homes. Want to learn more? Connect with us below! Danielle Miura on LinkedIn.Dr. Preston D. Cherry on LinkedIn.Dr. Preston D. Cherry's Website.Ready to explore these tax planning strategies for financial acceleration? Visit our website for more insights and personalized guidance. Click here to go to our website.

Recorded- April 17/18, 2024   Uploaded- April 20, 2024   We look at some new developments in Oakland and the development plan in the American Association. A conversation on new LMB rules and some happenings in the state of NJ. Included an interview with NY Boulders head scout Kevin Tuve.

Hoy Toño de y Enrique nos hablaron de lo que se viene en los playoffs de la NBA además del posible récord que se pueda romper en el Draft de la NFL, además los Diablos arrancan con paso perfecto la temporada de la LMB.

We workshop the LMB acronym to account for the Mexican League signing players of questionable character. We aren't just yanking Verdugo's chain, we are teaching you valuable vocabulary in multiple languages. We review your four options when you catch a home run ball during a game, starting with It Belongs To You. A little over a week in and our guys with slow starts are getting the bats in gear. We've got home runs bouncing off gloves and walls, we've got new nicknames (Turn and Burn O'Hearn!), and platelet infusions. Elly impresses off the field too, conducting his first press conference all in English. Wish wish Stephen Strasburg well on his retirement and as Nats fans we thank him for his service. Pottymouth turns our attention to Baseball United, the Dubai-based program that is attracting lots of attention and dollars from former MLB greats, and now Ronald Acuña Jr as well.  We remain suspicious. Shane and Spencer, just this Saturday, join the ranks of seriously injured pitchers and the MLBPA and MLB argue over the role of the pitch clock in all of this. Compton's MLB Youth Academy hosts the BFA Women's College Club Baseball Championships. Patti and Pottymouth got up early Saturday morning to make friends with Yankee fans for an important cause.  We participated in a live stream marathon “Pinstripes for a Cause” to help raise money for the World Parkinson Coalition. If you want to see us on coffee instead of craft beer, we start at 1:30 into the stream. Please consider adding your donation and add “Pinstripes for a Cause” or No Crying in Baseball to the notes.We say, “That's a Darwin test,” “One set of biceps was more productive than the other,” and “Is he pulling one of your six chains?” Fight the man, send your game balls to Meredith, get boosted, and find us on Twitter @ncibpodcast, on Facebook @nocryinginbball, Instagram @nocryinginbball and on the Interweb at nocryinginbball.com. Please take a moment to subscribe to the show, and leave us a review on Apple Podcasts or wherever you listen to NCiB. Become a supporter at Patreon to help us keep doing what we do. Say goodnight, Pottymouth.