Podcasts about Feasibility

Ductal carcinoma in situ (DCIS) represents a clinical crossroads in breast surgery—balancing the risks of over-treatment with the need to prevent invasive cancer. With new data from active monitoring trials, the pressure is on for surgeons to personalize care. Tune in to this essential episode to stay ahead of the curve on DCIS management and to hear expert insights from two leading breast surgical oncologists. Hosts: - Rashmi Kumar, MD, PhD Resident, University of Michigan General Surgery Residency Program Twitter/X: @RashmiJKumar - Melissa Pilewskie, MD Attending Breast Surgical Oncologist, Co-Director of the Weiser Family Center for Breast Cancer, Michigan Medicine Twitter/X: @MPilewskie -  Stephanie Downs-Canner, MD Attending Breast Surgical Oncologist & Physician-Scientist, Memorial Sloan Kettering Cancer Center, Program Director of the Breast Surgical Oncology Fellowship Training Program Twitter/X: @SDownsCanner Learning Objectives: - Define DCIS and explain its significance as a precursor to invasive breast cancer. - Discuss challenges in diagnosing and risk-stratifying DCIS. - Review current standards for surgical and adjuvant management of DCIS. - Understand the implications of new research, including the COMET trial, for low-risk DCIS. - Evaluate patient-centered strategies for managing DCIS and preventing over-treatment. References: - Worni M, Akushevich I, Greenup R, et al. Trends in Treatment Patterns and Outcomes for Ductal Carcinoma In Situ. J Natl Cancer Inst. 2015;107(12):djv263. PubMed - Francis A, Thomas J, Fallowfield L, et al. Addressing overtreatment of screen detected DCIS; the LORIS trial. Eur J Cancer. 2015 Jan;51(16):2296-303. PubMed - Elshof LE, Tryfonidis K, Slaets L, et al. Feasibility of a non-surgical management strategy for low-grade DCIS: The LORD study. Eur J Cancer. 2015;51(12):1497–1510. PubMed - Toss MS, et al. Ductal carcinoma in situ (DCIS): current management and future directions. Cancer Treat Rev. 2020;90:102091. PubMed - Comparative Effectiveness of Surgery versus Active Monitoring for Low-Risk DCIS (COMET) Trial Results. Early COMET Results: King TA, et al. Surgical excision versus active monitoring for low-risk ductal carcinoma in situ (DCIS): 2-year results of the COMET randomized trial. J Clin Oncol. 2024; e2400110. PubMed Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.   If you liked this episode, check out our recent episodes here: https://behindtheknife.org/listen Behind the Knife Premium: General Surgery Oral Board Review Course: https://behindtheknife.org/premium/general-surgery-oral-board-review Trauma Surgery Video Atlas: https://behindtheknife.org/premium/trauma-surgery-video-atlas Dominate Surgery: A High-Yield Guide to Your Surgery Clerkship: https://behindtheknife.org/premium/dominate-surgery-a-high-yield-guide-to-your-surgery-clerkship Dominate Surgery for APPs: A High-Yield Guide to Your Surgery Rotation: https://behindtheknife.org/premium/dominate-surgery-for-apps-a-high-yield-guide-to-your-surgery-rotation Vascular Surgery Oral Board Review Course: https://behindtheknife.org/premium/vascular-surgery-oral-board-audio-review Colorectal Surgery Oral Board Review Course: https://behindtheknife.org/premium/colorectal-surgery-oral-board-audio-review Surgical Oncology Oral Board Review Course: https://behindtheknife.org/premium/surgical-oncology-oral-board-audio-review Cardiothoracic Oral Board Review Course: https://behindtheknife.org/premium/cardiothoracic-surgery-oral-board-audio-review Download our App: Apple App Store: https://apps.apple.com/us/app/behind-the-knife/id1672420049 Android/Google Play: https://play.google.com/store/apps/details?id=com.btk.app&hl=en_US

Today my guests are Dr Alexander Perez and Dr Michael Topf. What we discuss with Dr Perez and Dr Topf: The challenge of documenting surgical specimens with traditional text and photos How 3D scanning improves accuracy and communication in pathology Integration into the gross room workflow with minimal time impact Clinical applications: tumor boards, surgical navigation, and radiation therapy planning Educational value: training residents, 3D printing, and virtual/augmented reality Patient-facing benefits, including education and visualization Cost accessibility: high-quality scanners for around $2,000 Collaboration and sharing of protocols to encourage wider adoption Future outlook: from long-term digital storage to medicolegal uses and beyond Links for this episode: The Path to PathA Pathologists' Assistant Shadowing Network Health Podcast Network  LabVine Learning Dress A Med scrubs Digital Pathology Club   Ex vivo 3D scanning and specimen mapping in anatomic pathology Augmented-Reality Surgery to Guide Head and Neck Cancer Re-resection: A Feasibility and Accuracy Study Visual pathology reports for improved collaboration at multidisciplinary head and neck tumor board   People of Pathology Podcast: Twitter Instagram  

An economist has raised concerns over NZ First's proposed reform for KiwiSaver contributions - and claimed they're not feasible. NZ First recently promised to make it compulsory and increase contributions from employers and workers to 10 percent - offset by a tax cut. Simplicity chief economist Shamubeel Eaqub says he approves of the idea of a compulsory scheme, but warns we can't afford a tax-funded one. LISTEN ABOVESee omnystudio.com/listener for privacy information.

An economist has raised concerns over NZ First's proposed reform for KiwiSaver contributions - and claimed they're not feasible. NZ First recently promised to make it compulsory and increase contributions from employers and workers to 10 percent - offset by a tax cut. Simplicity chief economist Shamubeel Eaqub says he approves of the idea of a compulsory scheme, but warns we can't afford a tax-funded one. LISTEN ABOVESee omnystudio.com/listener for privacy information.

En este episodio exploramos a fondo el mutismo acinético, una de las manifestaciones más desconcertantes tras un daño cerebral grave. Hablamos de su base neurofisiológica, su relación con el sistema dopaminérgico y los circuitos prefronto-subcorticales, y cómo se diferencia clínicamente de otros estados de conciencia alterada. Recorremos también las opciones terapéuticas más prometedoras, desde la estimulación multisensorial y la verticalización robótica hasta técnicas de neuromodulación como la estimulación cerebral profunda, la estimulación medular o la tDCS. Un episodio técnico, narrativo y lleno de preguntas clínicas clave, pensado para quienes trabajan día a día con pacientes que aún no responden... pero que podrían hacerlo. Referencias del episodio: 1. Arnts, H., van Erp, W. S., Lavrijsen, J. C. M., van Gaal, S., Groenewegen, H. J., & van den Munckhof, P. (2020). On the pathophysiology and treatment of akinetic mutism. Neuroscience and biobehavioral reviews, 112, 270–278. https://doi.org/10.1016/j.neubiorev.2020.02.006 8 https://pubmed.ncbi.nlm.nih.gov/32044373/). 2. Arnts, H., Tewarie, P., van Erp, W. S., Overbeek, B. U., Stam, C. J., Lavrijsen, J. C. M., Booij, J., Vandertop, W. P., Schuurman, R., Hillebrand, A., & van den Munckhof, P. (2022). Clinical and neurophysiological effects of central thalamic deep brain stimulation in the minimally conscious state after severe brain injury. Scientific reports, 12(1), 12932. https://doi.org/10.1038/s41598-022-16470-2 (https://pubmed.ncbi.nlm.nih.gov/35902627/). 3. Arnts, H., Tewarie, P., van Erp, W., Schuurman, R., Boon, L. I., Pennartz, C. M. A., Stam, C. J., Hillebrand, A., & van den Munckhof, P. (2024). Deep brain stimulation of the central thalamus restores arousal and motivation in a zolpidem-responsive patient with akinetic mutism after severe brain injury. Scientific reports, 14(1), 2950. https://doi.org/10.1038/s41598-024-52267-1 (https://pubmed.ncbi.nlm.nih.gov/38316863/). 4. Bai, Y., Xia, X., Li, X., Wang, Y., Yang, Y., Liu, Y., Liang, Z., & He, J. (2017). Spinal cord stimulation modulates frontal delta and gamma in patients of minimally consciousness state. Neuroscience, 346, 247–254. https://doi.org/10.1016/j.neuroscience.2017.01.036 (https://pubmed.ncbi.nlm.nih.gov/28147246/). 5. Bai, Y., Xia, X., Liang, Z., Wang, Y., Yang, Y., He, J., & Li, X. (2017). Corrigendum: Frontal Connectivity in EEG Gamma (30-45 Hz) Respond to Spinal Cord Stimulation in Minimally Conscious State Patients. Frontiers in cellular neuroscience, 11, 251. https://doi.org/10.3389/fncel.2017.00251 (https://pubmed.ncbi.nlm.nih.gov/28828002/). 6. Bai, Y., Lin, Y., & Ziemann, U. (2021). Managing disorders of consciousness: the role of electroencephalography. Journal of neurology, 268(11), 4033–4065. https://doi.org/10.1007/s00415-020-10095-z (https://pubmed.ncbi.nlm.nih.gov/32915309/). 7. Cairns, H., Oldfield, R. C., Pennybacker, J. B., & Whitteridge, D. (1941). Akinetic mutism with an epidermoid cyst of the 3rd ventricle. Brain, 64(4), 273–290 (https://academic.oup.com/brain/article-abstract/64/4/273/332088?redirectedFrom=fulltext). 8. Chen, Q., Huang, W., Tang, J., Ye, G., Meng, H., Jiang, Q., Ge, L., Li, H., Liu, L., Jiang, Q., & Wang, D. (2025). Reviving consciousness: The impact of short-term spinal cord stimulation on patients with early-onset prolonged disorders of consciousness. Journal of Neurorestoratology, 13(1), 100143. https://doi.org/10.1016/j.jnrt.2024.100143 (https://www.sciencedirect.com/science/article/pii/S2324242624000500?via%3Dihub). 9. Clavo, B., Robaina, F., Montz, R., Carames, M. A., Otermin, E., & Carreras, J. L. (2008). Effect of cervical spinal cord stimulation on cerebral glucose metabolism. Neurological research, 30(6), 652–654. https://doi.org/10.1179/174313208X305373 (https://pubmed.ncbi.nlm.nih.gov/18513465/). 10. Corazzol, M., Lio, G., Lefevre, A., Deiana, G., Tell, L., André-Obadia, N., Bourdillon, P., Guenot, M., Desmurget, M., Luauté, J., & Sirigu, A. (2017). Restoring consciousness with vagus nerve stimulation. Current biology : CB, 27(18), R994–R996. https://doi.org/10.1016/j.cub.2017.07.060 (https://pubmed.ncbi.nlm.nih.gov/28950091/). 11. Della Pepa, G. M., Fukaya, C., La Rocca, G., Zhong, J., & Visocchi, M. (2013). Neuromodulation of vegetative state through spinal cord stimulation: where are we now and where are we going?. Stereotactic and functional neurosurgery, 91(5), 275–287. https://doi.org/10.1159/000348271 (https://pubmed.ncbi.nlm.nih.gov/23797266/). 12. De Luca, R., Bonanno, M., Vermiglio, G., Trombetta, G., Andidero, E., Caminiti, A., Pollicino, P., Rifici, C., & Calabrò, R. S. (2022). Robotic Verticalization plus Music Therapy in Chronic Disorders of Consciousness: Promising Results from a Pilot Study. Brain sciences, 12(8), 1045. https://doi.org/10.3390/brainsci12081045 (https://pubmed.ncbi.nlm.nih.gov/36009107/). 13. Dong, X., Tang, Y., Zhou, Y., & Feng, Z. (2023). Stimulation of vagus nerve for patients with disorders of consciousness: a systematic review. Frontiers in neuroscience, 17, 1257378. https://doi.org/10.3389/fnins.2023.1257378 (https://pubmed.ncbi.nlm.nih.gov/37781261/). 14. Fan, W., Fan, Y., Liao, Z., & Yin, Y. (2023). Effect of Transcranial Direct Current Stimulation on Patients With Disorders of Consciousness: A Systematic Review and Meta-analysis. American journal of physical medicine & rehabilitation, 102(12), 1102–1110. https://doi.org/10.1097/PHM.0000000000002290 (https://pubmed.ncbi.nlm.nih.gov/37205736/). 15. Frazzitta, G., Zivi, I., Valsecchi, R., Bonini, S., Maffia, S., Molatore, K., Sebastianelli, L., Zarucchi, A., Matteri, D., Ercoli, G., Maestri, R., & Saltuari, L. (2016). Effectiveness of a Very Early Stepping Verticalization Protocol in Severe Acquired Brain Injured Patients: A Randomized Pilot Study in ICU. PloS one, 11(7), e0158030. https://doi.org/10.1371/journal.pone.0158030 (https://pubmed.ncbi.nlm.nih.gov/27447483/). 16. Jang, S. H., & Byun, D. H. (2022). A Review of Studies on the Role of Diffusion Tensor Magnetic Resonance Imaging Tractography in the Evaluation of the Fronto-Subcortical Circuit in Patients with Akinetic Mutism. Medical science monitor : international medical journal of experimental and clinical research, 28, e936251. https://doi.org/10.12659/MSM.936251 (https://pubmed.ncbi.nlm.nih.gov/35181647/). 17. Lombardi, F., Taricco, M., De Tanti, A., Telaro, E., & Liberati, A. (2002). Sensory stimulation for brain injured individuals in coma or vegetative state. The Cochrane database of systematic reviews, 2002(2), CD001427. https://doi.org/10.1002/14651858.CD001427 (https://pmc.ncbi.nlm.nih.gov/articles/PMC7045727/). 18. Magee, W. L., & O'Kelly, J. (2015). Music therapy with disorders of consciousness: current evidence and emergent evidence-based practice. Annals of the New York Academy of Sciences, 1337, 256–262. https://doi.org/10.1111/nyas.12633 (https://pubmed.ncbi.nlm.nih.gov/25773642/). 19. Mateo-Sierra, O., Gutiérrez, F.A., Fernández-Carballal, C., Pinilla, D., Mosqueira, B., Iza, B., & Carrillo, R.. (2005). Mutismo acinético relacionado con hidrocefalia y cirugía cerebelosa tratado con bromocriptina y efedrina: revisión fisiopatológica. Neurocirugía, 16(2), 134-141. (https://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-14732005000200005). 20. Noé, E., Ferri, J., Colomer, C., Moliner, B., O'Valle, M., Ugart, P., Rodriguez, C., & Llorens, R. (2020). Feasibility, safety and efficacy of transauricular vagus nerve stimulation in a cohort of patients with disorders of consciousness. Brain stimulation, 13(2), 427–429. https://doi.org/10.1016/j.brs.2019.12.005 (https://pubmed.ncbi.nlm.nih.gov/31866491/). 21. Norwood, M. F., Lakhani, A., Watling, D. P., Marsh, C. H., & Zeeman, H. (2023). Efficacy of Multimodal Sensory Therapy in Adult Acquired Brain Injury: A Systematic Review. Neuropsychology review, 33(4), 693–713. https://doi.org/10.1007/s11065-022-09560-5 (https://pubmed.ncbi.nlm.nih.gov/36056243/). 22. O'Neal, C. M., Schroeder, L. N., Wells, A. A., Chen, S., Stephens, T. M., Glenn, C. A., & Conner, A. K. (2021). Patient Outcomes in Disorders of Consciousness Following Transcranial Magnetic Stimulation: A Systematic Review and Meta-Analysis of Individual Patient Data. Frontiers in neurology, 12, 694970. https://doi.org/10.3389/fneur.2021.694970 (https://pubmed.ncbi.nlm.nih.gov/34475848/). 23. Schiff, N. D., Giacino, J. T., Kalmar, K., Victor, J. D., Baker, K., Gerber, M., Fritz, B., Eisenberg, B., Biondi, T., O'Connor, J., Kobylarz, E. J., Farris, S., Machado, A., McCagg, C., Plum, F., Fins, J. J., & Rezai, A. R. (2007). Behavioural improvements with thalamic stimulation after severe traumatic brain injury. Nature, 448(7153), 600–603. https://doi.org/10.1038/nature06041 (https://pubmed.ncbi.nlm.nih.gov/17671503/). 24. Schiff N. D. (2016). Central thalamic deep brain stimulation to support anterior forebrain mesocircuit function in the severely injured brain. Journal of neural transmission (Vienna, Austria : 1996), 123(7), 797–806. https://doi.org/10.1007/s00702-016-1547-0 (https://pubmed.ncbi.nlm.nih.gov/27113938/). 25. Schiff N. D. (2023). Mesocircuit mechanisms in the diagnosis and treatment of disorders of consciousness. Presse medicale (Paris, France : 1983), 52(2), 104161. https://doi.org/10.1016/j.lpm.2022.104161 (https://pubmed.ncbi.nlm.nih.gov/36563999/). 26. Shimojo, S., & Shams, L. (2001). Sensory modalities are not separate modalities: plasticity and interactions. Current opinion in neurobiology, 11(4), 505–509. https://doi.org/10.1016/s0959-4388(00)00241-5 (https://pubmed.ncbi.nlm.nih.gov/11502399/). 27. Stephens, T. M., Young, I. M., O'Neal, C. M., Dadario, N. B., Briggs, R. G., Teo, C., & Sughrue, M. E. (2021). Akinetic mutism reversed by inferior parietal lobule repetitive theta burst stimulation: Can we restore default mode network function for therapeutic benefit?. Brain and behavior, 11(8), e02180. https://doi.org/10.1002/brb3.2180 (https://pubmed.ncbi.nlm.nih.gov/34145791/). 28. Piedade, G. S., Assumpcao de Monaco, B., Guest, J. D., & Cordeiro, J. G. (2023). Review of spinal cord stimulation for disorders of consciousness. Current opinion in neurology, 36(6), 507–515. https://doi.org/10.1097/WCO.0000000000001222 (https://pubmed.ncbi.nlm.nih.gov/37889524/). 29. Rosenfelder, M. J., Helmschrott, V. C., Willacker, L., Einhäupl, B., Raiser, T. M., & Bender, A. (2023). Effect of robotic tilt table verticalization on recovery in patients with disorders of consciousness: a randomized controlled trial. Journal of neurology, 270(3), 1721–1734. https://doi.org/10.1007/s00415-022-11508-x (https://pubmed.ncbi.nlm.nih.gov/36536249/). 30. Thibaut, A., Bruno, M. A., Ledoux, D., Demertzi, A., & Laureys, S. (2014). tDCS in patients with disorders of consciousness: sham-controlled randomized double-blind study. Neurology, 82(13), 1112–1118. https://doi.org/10.1212/WNL.0000000000000260 (https://pubmed.ncbi.nlm.nih.gov/24574549/). 31. Visocchi, M., Della Pepa, G. M., Esposito, G., Tufo, T., Zhang, W., Li, S., & Zhong, J. (2011). Spinal cord stimulation and cerebral hemodynamics: updated mechanism and therapeutic implications. Stereotactic and functional neurosurgery, 89(5), 263–274. https://doi.org/10.1159/000329357 (https://pubmed.ncbi.nlm.nih.gov/21860253/). 32. Yang, Y., He, Q., Xia, X., Dang, Y., Chen, X., He, J., & Zhao, J. (2022). Long-term functional prognosis and related factors of spinal cord stimulation in patients with disorders of consciousness. CNS neuroscience & therapeutics, 28(8), 1249–1258. https://doi.org/10.1111/cns.13870 (https://pubmed.ncbi.nlm.nih.gov/35619213/). 33. Yang, Y., He, Q., Dang, Y., Xia, X., Xu, X., Chen, X., Zhao, J., & He, J. (2023). Long-term functional outcomes improved with deep brain stimulation in patients with disorders of consciousness. Stroke and vascular neurology, 8(5), 368–378. https://doi.org/10.1136/svn-2022-001998 (https://pubmed.ncbi.nlm.nih.gov/36882201/). 34. Yu, Y. T., Yang, Y., Wang, L. B., Fang, J. L., Chen, Y. Y., He, J. H., & Rong, P. J. (2017). Transcutaneous auricular vagus nerve stimulation in disorders of consciousness monitored by fMRI: The first case report. Brain stimulation, 10(2), 328–330. https://doi.org/10.1016/j.brs.2016.12.004 (https://pubmed.ncbi.nlm.nih.gov/28017322/). 35. Zhou, Y. F., Kang, J. W., Xiong, Q., Feng, Z., & Dong, X. Y. (2023). Transauricular vagus nerve stimulation for patients with disorders of consciousness: A randomized controlled clinical trial. Frontiers in neurology, 14, 1133893. https://doi.org/10.3389/fneur.2023.1133893 (https://pubmed.ncbi.nlm.nih.gov/36937511/). 36. Zhuang, Y., Yang, Y., Xu, L., Chen, X., Geng, X., Zhao, J., & He, J. (2022). Effects of short-term spinal cord stimulation on patients with prolonged disorder of consciousness: A pilot study. Frontiers in neurology, 13, 1026221. https://doi.org/10.3389/fneur.2022.1026221 (https://pubmed.ncbi.nlm.nih.gov/36313512/). 37. Zuo, J., Tao, Y., Liu, M., Feng, L., Yang, Y., & Liao, L. (2021). The effect of family-centered sensory and affective stimulation on comatose patients with traumatic brain injury: A systematic review and meta-analysis. International journal of nursing studies, 115, 103846. https://doi.org/10.1016/j.ijnurstu.2020.103846 (https://pubmed.ncbi.nlm.nih.gov/33485101/).

Summary The podcast discusses a recent pilot study on the effects of passive blood flow restriction (BFR) exercise on muscle atrophy following total knee replacement surgery. The conversation highlights the significant muscle mass loss that occurs post-surgery and the potential of BFR to mitigate this loss. The study design, methodology, and key findings are explored, emphasizing the importance of early intervention and the feasibility of implementing BFR in clinical settings. The hosts discuss the implications of the findings for rehabilitation practices and future research directions. Chapters 00:00 Introduction and Overview of the Study 03:15 Understanding Muscle Atrophy Post-Surgery 07:12 The Role of Blood Flow Restriction in Rehabilitation 12:53 Study Design and Methodology 15:35 Key Findings and Implications of the Study 20:54 Exploring Remote Ischemic Preconditioning 22:42 Functional Outcomes and Clinical Significance 25:11 Grip Strength Recovery and Clinical Changes 27:01 Safety and Feasibility of BFR 28:42 Implementing BFR in Clinical Practice 30:25 Prehabilitation and Postoperative Care 32:47 Expanding Applications of BFR in Acute Care Podcast Intro Attribution Song: Legendary Music by: CreatorMix.com Video: https://youtu.be/_oaZzkn0bW4 Podcast Outro Attribution Song: Smoke Rising Music by: CreatorMix.com Video: https://youtu.be/_oaZzkn0bW4

Summary In this episode of Develop This!, Dennis Fraise and Rick Kiernan with Convergent Nonprofit Solutions discuss the evolving landscape of funding for economic development organizations. They explore the shift from traditional funding methods to a focus on workforce development, housing, placemaking, and childcare. Rick shares insights from his extensive experience in fundraising and highlights the importance of feasibility studies in understanding community needs. The conversation emphasizes the necessity of having a well-structured plan to attract funding and support for various initiatives that enhance community appeal and address workforce challenges. Takeaways Economic development funding has evolved significantly over the years. Workforce development is now the primary focus for economic development organizations. Feasibility studies provide critical insights into community needs. Housing shortages are a major barrier to attracting talent. Placemaking is increasingly important for community attractiveness. Childcare availability directly impacts workforce participation. Community engagement is essential for successful fundraising campaigns. Economic development organizations must adapt to changing priorities. Collaboration with local stakeholders enhances fundraising efforts. A well-defined plan is crucial for securing funding and support.

WWE fans… you're not beating the allegations this week

Properties for Sale on the North Side?  We want to buy them. Email: StraightUpChicagoInvestor@gmail.com Have a vacancy? We can place your next tenant and give you back 30-40 hours of your time. Learn more: GCRealtyInc.com/tenant-placement Has Property Mgmt become an opportunity cost for you? Let us lower your risk and give you your time back to grow. Learn more: GCRealtyinc.com ============= Fernando Angelucci returns to the podcast to explain how he has rapidly grown his self storage business and the drivers behind increasing self storage demand! Fernando explains his marketing strategy to optimize deal flow despite the low inventory environment. He delves deep into the underwriting and feasibility studies performed on self storage investments to maximize returns. Fernando provides the 101 on various financing options and repositioning strategies for self storage investments. He closes with a motivating 5-year outlook including a detailed plan to reach financial independence! If you enjoy today's episode, please leave us a review and share with someone who may also find value in this content! ============= Connect with Mark and Tom: StraightUpChicagoInvestor.com Email the Show: StraightUpChicagoInvestor@gmail.com Guests: Fernando Angelucci, Self Storage Syndicated Equities Link: Fernando's Instagram Link: SUCI Ep 86 - Fernando Angelucci Link: Vagabonding (Book Recommendation) Link: SUCI Ep 392 - Cost Seg Kev Guest Questions 01:49 Housing Provider Tip - Be sure to perform maintenance on AC units after a long summer! 03:25 Intro to our guest, Fernando Angelucci! 06:41 Growing a portfolio in a low inventory market! 12:10 Feasibility studies on self storage projects. 16:44 Building a self storage investment team! 21:56 Financing self storage deals. 37:33 Repositioning a self storage investment. 47:57 Obtaining special use permits. 52:01 Ideal self storage projects! 55:23 Fernando's 5-year outlook. 60:26 What is your competitive advantage? 62:55 One piece of advice for new investors. 63:32 What do you do for fun? 64:14 Good book, podcast, or self development activity that you would recommend?  64:48 Local Network Recommendation?  65:53 How can the listeners learn more about you and provide value to you? ----------------- Production House: Flint Stone Media Copyright of Straight Up Chicago Investor 2025.

This webinar will look at stages of the RI/FS, from RMM through the FS.  Presentations will discuss how to create risk scenarios for evaluation using the Risk Management Methodology (RMM) and explain how that can influence the development of remedial alternatives by considering both contamination and land use.  The presentations will look at an example site and at a case study.  We will also discuss the use of "FS alternatives panels" to facilitate the development of remedial alternatives and attempt to get buy-in from various members of the project team. To view this archive online or download the slides associated with this seminar, please visit http://www.clu-in.org/conf/tio/m2s2fy24-1_082825/

This webinar will look at stages of the RI/FS, from RMM through the FS.  Presentations will discuss how to create risk scenarios for evaluation using the Risk Management Methodology (RMM) and explain how that can influence the development of remedial alternatives by considering both contamination and land use.  The presentations will look at an example site and at a case study.  We will also discuss the use of "FS alternatives panels" to facilitate the development of remedial alternatives and attempt to get buy-in from various members of the project team. To view this archive online or download the slides associated with this seminar, please visit http://www.clu-in.org/conf/tio/m2s2fy24-1_082825/

En lo último en salud y fitness edición de agosto 2025, damos un paseo por las últimas tendencias, investigaciones y noticias en el mundo de la salud y el fitness.Este mes traemos un episodio cargado de temas que van a cambiar la forma en que piensas sobre tu entrenamiento y tu salud.Vamos a hablar de algo que seguro te has preguntado alguna vez: ¿entrenar en ayunas te hace perder músculo o es solo un mito? También veremos qué hay de cierto en toda esa publicidad sobre probióticos para atletas, y si realmente necesitas gastar tu dinero en ellos.Además, analizaremos a la creatina, pero no solo como el suplemento estrella para tus músculos: resulta que podría tener efectos sorprendentes en tu cerebro, especialmente contra el Alzheimer. Y para cerrar, desmontamos uno de los grandes mitos de la medicina moderna: que la diabetes tipo 2 es una condición de por vida.Atajos Del Episodio02:25 - Entrenar en Ayunas: ¿Estás Quemando Músculo o Quemando Mitos?107:32 - Probióticos para Atletas: ¿La Revolución Intestinal o Solo Mucho Ruido y Pocos Resultados?212:20 - Creatina: El Suplemento para Músculos que Podría Rescatar tu Cerebro316:32 - Diabetes Tipo 2: ¿Sentencia de por Vida o Problema Reversible?420:16 - Alimentos Ultraprocesados: La Ruta Directa de la Despensa al Hígado Graso5Referencias:1.      Vieira, A. F. & Blanco-Rambo…, E. Impact of Overnight Fasted State Versus Fed State on Adaptations to Resistance Training: A Randomized Clinical Trial. … Journal of Sport … (2025).2.      Shirkoohi, N. M., Mohammadi, H. & Gallaly…, D. Q. The effects of probiotic supplementation on body composition, recovery following exercise‐induced muscle damage, and exercise performance: A systematic review …. Physiological … (2025).3.      Smith, A. N., Choi, I. Y., Lee, P. & Sullivan…, D. K. Creatine monohydrate pilot in Alzheimer's: Feasibility, brain creatine, and cognition. … Research & Clinical … (2025).4.      Zhang, S. et al. Effect of hypoglycemic agents with weight loss effect plus a high protein diet and moderate exercise on diabetes remission in adults with obesity and type 2 diabetes: a …. BMC medicine (2025).5.      Guo, C., Yang, W., Zhou, J. & Wang…, J. J. Ultra‐Processed Food Intake and Risk of Adverse Liver Outcomes: A Meta‐Analysis. Journal of Food … (2025).

On Episode #178 of the PricePlow Podcast, Ben and guest co-host Joey Savage take listeners inside Veritacor Manufacturing in Luling, Texas, for an exclusive facility tour and in-depth conversation with founders Frank Santos and Derek Curtiss. This episode provides a rare behind-the-scenes look at what it takes to build and operate an NSF-certified, GMP-compliant supplement manufacturing facility from the ground up. From their humble beginnings with a single encapsulator to their current 32,500 square foot operation, Frank and Derek share the meticulous processes, quality control systems, and attention to detail that set Veritacor apart in the competitive contract manufacturing landscape. The discussion dives deep into the technical aspects of supplement production, from vendor qualification and raw material testing to the critical differences between ribbon and paddle blenders, while also exploring their ambitious growth plans to reach 200,000 square feet of manufacturing space. This discussion and forthcoming facility tour showcases not just Veritacor's impressive capabilities in powder blending, encapsulation, and fulfillment, but also their commitment to elevating industry standards through rigorous third-party auditing, comprehensive SOPs, and a culture of continuous improvement. Whether you're a brand owner looking for a manufacturing partner or simply interested in understanding how supplements are made at the highest quality levels, this episode delivers unprecedented insights into modern nutraceutical manufacturing. Subscribe to the PricePlow Podcast to hear more conversations with industry innovators and manufacturers shaping the future of supplements! https://blog.priceplow.com/podcast/veritacor-supplement-manufacturing-178 Video: Inside Veritacor Manufacturing Facility Tour https://www.youtube.com/watch?v=An7FhkG9bZE Detailed Show Notes: GMP Excellence and Manufacturing Innovation (0:00) – Introduction: A Dream Realized in Manufacturing (1:30) – Derek's Journey: From Indian Botanicals to COO (3:30) – Building from Scratch: The Veritacor Origin Story (6:00) – The Path to NSF Certification: Setting the Standard (8:15) – Customer Onboarding: From Formula to Feasibility (10:15) – Vendor Qualification: The Foundation of Quality (12:15) – The Critical Weighing and Blending Process (14:30) – Blending Technology Deep Dive: Ribbon vs. Paddle vs. Bin (17:15) – Quality Control: Multi-Point Testing and Validation (19:45) – Manufacturing Capabilities and Core Specializations (22:30) – Core Culture: Demonstrating Capabilities Through House Brands (25:00) – Facility Evolution: Creative Solutions and Strategic Growth (28:00) – NSF Audit Stories: Learning from Scrutiny (31:00) – Stability Testing and Shelf Life Determination (34:00) – Third-Party Logistics: Complete Supply Chain Solutions (36:30) – NetSuite Implementation: Digital Transformation (39:00) – Community Impact: Building Local Talent (42:00) – The Business of Manufacturing: Costs and Timelines (45:00) – Blender Selection Strategy: The Right Tool for Each Job (48:00) – Expansion Vision: The Path to 200,000 Square Feet (51:00) – Product Categories and Sp... Read more on the PricePlow Blog

With the Fed's latest decision to hold rates, one thing became clear- tariffs are already affecting the real estate market.This week on Not Your Average Insights, JWB Co-Founder Gregg Cohen and host Pablo Gonzalez break down the role tariffs play in the Fed's decision, and other headlines to consider.We'll talk about:•⁠  ⁠Why the Fed's pause on rate hikes is tied to tariffs•⁠  ⁠What Florida's governor is proposing that has everyone looking at Florida real estate•⁠  ⁠Where the “10 Slowest Housing Markets” were reported to be, and which ones we agree with•⁠  ⁠and more!Listen NOW!Chapters:00:00 Introduction to Not Your Average Insights01:24 Welcome Back to the Show04:13 Discussion on Fed's Interest Rate Decision06:05 Impact of Tariffs on Housing Market13:05 Jobs Report and Fed's Future Decisions19:34 Ron DeSantis' Proposal to Eliminate Property Taxes25:06 Debating Property Tax Elimination25:44 Governor's Perspective on Government Spending26:19 Impact of Sales Tax on Different Income Groups26:54 Feasibility of Sales Tax Increase28:57 Potential Property Tax Rebate29:14 Revisions to Government Job Numbers32:52 Interest Rates and Mortgage Market36:59 JWB Cares Fundraising Update38:25 Analyzing Housing Market Data42:54 Long-Term Investment Strategies49:40 Conclusion and Upcoming EventsStay connected to us! Join our real estate investor community LIVE: https://jwbrealestatecapital.com/nyai/Schedule a Turnkey strategy call: https://jwbrealestatecapital.com/turnkey/ *Get social with us:*Subscribe to our channel  @notyouraverageinvestor  Subscribe to  @JWBRealEstateCompanies  

Gene Marks sits down with Senior Benefits Manager at Paychex, Tami Tillery, to answer the top questions from a recent webinar on the evolving landscape of employee benefits. They discuss how businesses, particularly in rural and underserved areas, can creatively manage healthcare costs while providing robust employee benefits. A major focus is on leveraging technology and innovative solutions such as telehealth, mobile health units, and AI to enhance employee well-being in a cost-effective manner. Whether you're a small business or a large enterprise, understanding how to effectively manage benefits and costs is crucial. Watch the on-demand webinar, Sustainable Benefit Strategies for Every Business Stage, at: https://bit.ly/4mt98uO Have a question for upcoming episodes or a topic you want covered? Let us know: https://payx.me/thrivetopics Topics include: 00:00: Episode preview 00:41: Overview of the "Sustainable Benefit Strategies" webinar 01:28: Rising healthcare costs insights 02:27: Strategies for rural employers 05:19: Healthcare costs and age groups 07:10: How to pick insurance plan designs from different carriers 10:21: Feasibility and advice for small businesses to offer group insurance 14:33: Getting the right benefits support 20:25: Strategies for rural employers balancing costs and quality 23:50: Predictions on future benefits trends 30:17: Wrap up and thank you DISCLAIMER: The information presented in this podcast, and that is further provided by the presenter, should not be considered legal or accounting advice, and should not substitute for legal, accounting, or other professional advice in which the facts and circumstances may warrant. We encourage you to consult legal counsel as it pertains to your own unique situation(s) and/or with any specific legal questions you may have.

In this episode of THE MENTORS RADIO, Host Tom Loarie talks with Mai Nguyen, PhD, the remarkable 36-year-old neuroscientist who is the co-founder and CEO of OptoCeutics and the inventor of EVY LIGHT®, a breakthrough light-based therapy aimed at slowing the progression of Alzheimer's and other memory disorders. Her journey is anything but ordinary. Born in Vietnam, raised in California as the youngest of nine children in a struggling family, she spent her childhood at a local Flea Market and then went on to earn a PhD in neuroscience. But it was a "chance" conversation with a Danish professor that changed her life, and quite likely the lives of millions who will benefit from her decision. In this episode, you'll explore the science behind Dr. Mai Nguyen's light therapy innovation, her deeply personal and unlikely entrepreneurial journey and the powerful values that have guided her. This is a conversation about courage, healing and what it means to be a leader with heart and grit.  Listen to THE MENTORS RADIO podcast anywhere, any time, on any platform, including Spotify and Apple, just click here! Of course, we are always grateful for your 5-star review on Spotify and Apple podcasts, which helps us reach even more people!! SHOW NOTES: MAI NGUYEN, Ph.D.: BIO: https://optoceutics.com/about/about-mai-nguyen/ COMPANY: https://optoceutics.com/ ARTICLES: Mai Nguyen of OptoCeutics: Five Things I Wish Someone Told Me Before I Became a CEO Can flashing lights stall Alzheimer's? What the science shows Safety, Feasibility, and Potential Clinical Efficacy of 40 Hz Invisible Spectral Flicker versus Placebo in Patients with Mild-to-Moderate Alzheimer's Disease: A Randomized, Placebo-Controlled, Double-Blinded, Pilot Study

Political theorist Annabel Brett of Cambridge University explores how the concept of “moral possibility” shapes law, politics, and public obligation. She explains that laws must be realistic for people to follow—what is morally possible varies by individual, culture, time, and circumstance. Drawing on early modern Catholic legal theory, Brett discusses how extreme demands (like enduring war or plague) may justify higher expectations, but only temporarily. She examines how colonial Spanish officials misused this framework to justify forced labor in Peru, wrongly claiming it aligned with indigenous customs. Brett contrasts this with more democratic approaches to law, like Domingo de Soto's defense of beggars' rights, which take individuals' real conditions seriously. Ultimately, she shows how moral possibility is deeply tied to time, virtue, and justice. Commentary is provided by David Dyzenhaus of the University of Toronto. Series: "UC Berkeley Graduate Lectures" [Public Affairs] [Humanities] [Show ID: 40430]

Political theorist Annabel Brett of Cambridge University explores how the concept of “moral possibility” shapes law, politics, and public obligation. She explains that laws must be realistic for people to follow—what is morally possible varies by individual, culture, time, and circumstance. Drawing on early modern Catholic legal theory, Brett discusses how extreme demands (like enduring war or plague) may justify higher expectations, but only temporarily. She examines how colonial Spanish officials misused this framework to justify forced labor in Peru, wrongly claiming it aligned with indigenous customs. Brett contrasts this with more democratic approaches to law, like Domingo de Soto's defense of beggars' rights, which take individuals' real conditions seriously. Ultimately, she shows how moral possibility is deeply tied to time, virtue, and justice. Commentary is provided by David Dyzenhaus of the University of Toronto. Series: "UC Berkeley Graduate Lectures" [Public Affairs] [Humanities] [Show ID: 40430]

Political theorist Annabel Brett of Cambridge University explores how the concept of “moral possibility” shapes law, politics, and public obligation. She explains that laws must be realistic for people to follow—what is morally possible varies by individual, culture, time, and circumstance. Drawing on early modern Catholic legal theory, Brett discusses how extreme demands (like enduring war or plague) may justify higher expectations, but only temporarily. She examines how colonial Spanish officials misused this framework to justify forced labor in Peru, wrongly claiming it aligned with indigenous customs. Brett contrasts this with more democratic approaches to law, like Domingo de Soto's defense of beggars' rights, which take individuals' real conditions seriously. Ultimately, she shows how moral possibility is deeply tied to time, virtue, and justice. Commentary is provided by David Dyzenhaus of the University of Toronto. Series: "UC Berkeley Graduate Lectures" [Public Affairs] [Humanities] [Show ID: 40430]

Political theorist Annabel Brett of Cambridge University explores how the concept of “moral possibility” shapes law, politics, and public obligation. She explains that laws must be realistic for people to follow—what is morally possible varies by individual, culture, time, and circumstance. Drawing on early modern Catholic legal theory, Brett discusses how extreme demands (like enduring war or plague) may justify higher expectations, but only temporarily. She examines how colonial Spanish officials misused this framework to justify forced labor in Peru, wrongly claiming it aligned with indigenous customs. Brett contrasts this with more democratic approaches to law, like Domingo de Soto's defense of beggars' rights, which take individuals' real conditions seriously. Ultimately, she shows how moral possibility is deeply tied to time, virtue, and justice. Commentary is provided by David Dyzenhaus of the University of Toronto. Series: "UC Berkeley Graduate Lectures" [Public Affairs] [Humanities] [Show ID: 40430]

Most people assume creatine is only for bodybuilders, but new research is challenging that belief. In this episode, Chalene dives into the surprising, science-backed benefits of creatine for women, particularly those in midlife. From brain health and bone density to hormonal support and cognitive function, this supplement might be one of the most underrated tools for aging powerfully. She also busts common myths like weight gain and bloating, and explains why some experts are calling it “the magnesium of 2025.” If you're curious about how to take it, which brands are trustworthy, and how to avoid getting scammed, this episode lays it all out. Watch this episode on YouTube this Sunday!!  https://www.youtube.com/@chalenejohnson/videos  

La Dra. Ana Valeria Aguirre, investigadora del Hospital Nacional de Rehabilitación MedStar, entrevista a la Dra. Carter Denny, Neuróloga Vascular e investigadora clínica de MedStar y la Universidad de Georgetown, sobre el artículo "Seguridad, viabilidad y eficacia de la estimulación transcutánea del nervio tibial en la vejiga neurogénica con lesión aguda de la médula espinal: un ensayo piloto aleatorizado de control". En este episodio las Doctoras analizaran este tipo de intervención, que consiste en la estimulación del nervio tibial, utilizada en otras poblaciones, y cómo se utiliza actualmente para mejorar la función vesical en personas con vejiga neurogénica. Para acceder a este artículo de la revista, haga clic aquí:  https://www.sciencedirect.com/science/article/abs/pii/S1094715921019917?via%3Dihub https://bladderbuzzpodcast.buzzsprout.com/1290071/episodes/10293954-journal-article-safety-feasibility-and-efficacy-of-transcaternity-tibial-nerve-stimulation-in-acute-spinal-cord-injury-neurogenic-bladder Safety, Feasibility, and Efficacy of Transcutaneous Tibial Nerve Stimulation in Acute Spinal Cord Injury Neurogenic Bladder: A Randomized Control Pilot Trial - ScienceDirect

Dr. Linda Chu reviews recent articles in the Generative AI Collection, covering clinical history extraction, case interpretation with vision language models, and report proofreading.   The articles covered in the podcast are: Leveraging Large Language Models to Generate Clinical Histories for Oncologic Imaging Requisitions | Radiology   Assessing Completeness of Clinical Histories Accompanying Imaging Orders Using Adapted Open-Source and Closed-Source Large Language Models | Radiology   Impact of Multimodal Prompt Elements on Diagnostic Performance of GPT-4V in Challenging Brain MRI Cases | Radiology   Generative Large Language Models Trained for Detecting Errors in Radiology Reports | Radiology   Large-Scale Validation of the Feasibility of GPT-4 as a Proofreading Tool for Head CT Reports | Radiology

AI for Site Feasibility: Streamlining Zoning, Codes, and Permits for ArchitectsIn this episode of the podcast, Gayathri (G3) Venkataraman, founder and CEO of Dota.ai, shares her inspiring journey from leading product teams at Microsoft and DocuSign to launching her own startup focused on transforming site feasibility and permitting in the construction industry. Frustrated by outdated, fragmented data systems, G3 created Dota.ai to consolidate information on land use, zoning, and building codes into one streamlined, accessible platform. She explains how AI can dramatically speed up the pre-development process, allowing architects and developers to make smarter, faster decisions.G3 dives into the unique challenges of integrating advanced technology into the traditionally conservative construction sector and discusses the future potential of AI to reshape urban planning and civic tech. She also reflects on her mission to empower real estate and design professionals, ultimately driving both operational efficiency and community impact. As a nonprofit board chair, G3 believes deeply in using technology for the greater good and shares insights on balancing innovation with societal responsibility.Throughout the conversation, she offers practical advice to small firm architects on embracing change and cultivating a mindset of continuous improvement in their practices.This week at EntreArchitect Podcast, AI for Site Feasibility: Streamlining Zoning, Codes, and Permits for Architects with Gayathri (G3) Venkataraman.Connect with G3 online at Dota.ai or find her on LinkedIn and Instagram.Please Visit Our Platform SponsorsArcatemy is Arcat's Continuing Education Program. Listen to Arcat's Detailed podcast and earn HSW credits. As a trusted provider, Arcat ensures you earn AIA CE credits while advancing your expertise and career in architecture. Learn more at Arcat.com/continuing-education.Visit our Platform Sponsors today and thank them for supporting YOU... The EntreArchitect Community of small firm architects.

Portable Device Feasibility Abstract Chris and Fred discuss how we assess product feasibility … at the concept stage! Great topic. Key Points Join Chris and Fred as they discuss product feasibility when it is nothing more than a concept. There is a lot to unpack here! This comes from a question raised by a Singaporean […] The post SOR 1083 Portable Device Feasibility appeared first on Accendo Reliability.

The NACE Journal Club with Dr. Neil Skolnik, provides review and analysis of recently published journal articles important to the practice of primary care medicine. In this episode Dr. Skolnik and guests review the following publications:1. Effects of Combining Coronary Calcium Score With Treatment on PlaqueProgression in Familial Coronary Artery Disease A Randomized Clinical Trial JAMA 2025. Discussion by:Guest: Michael J. Blaha, MD, MPHProfessor of Cardiology and Epidemiology and presently serves as theDirector of Clinical Research for the Johns Hopkins Ciccarone Center for thePrevention of Cardiovascular DiseaseDirector of the Cardiometabolic ClinicProgram Director for the Preventive Cardiology Fellowship.2. Creatine monohydrate pilot in Alzheimer's: Feasibility, brain creatine, and cognition. Alzheimer's Dement. 2025. Discussion by:Guest:Michael Devano, DO Attending Family Physician Christiana Care Health System3. Structured Exercise after Adjuvant Chemotherapy for Colon Cancer. The New England Journal of Medicine. Discussion by:Guest:Joseph Gonnella, MD Resident– Family MedicineResidency Program, Jefferson Health – AbingtonMedical Director and Host, Neil Skolnik, MD, is an academic family physician who sees patients and teaches residents and medical students as professor of Family and Community Medicine at the Sidney Kimmel Medical College, Thomas Jefferson University and Associate Director, Family Medicine Residency Program at Abington Jefferson Health in Pennsylvania. Dr. Skolnik graduated from Emory University School of Medicine in Atlanta, Georgia, and did his residency training at Thomas Jefferson University Hospital in Philadelphia, PA. This Podcast Episode does not offer CME/CE Credit. Please visit http://naceonline.com to engage in more live and on demand CME/CE content.

Any donation is greatly appreciated! 47e6GvjL4in5Zy5vVHMb9PQtGXQAcFvWSCQn2fuwDYZoZRk3oFjefr51WBNDGG9EjF1YDavg7pwGDFSAVWC5K42CBcLLv5U OR DONATE HERE: https://www.monerotalk.live/donate TODAY'S SHOW: In this episode of Monero Talk, Douglas Tuman speaks with cryptographic engineer Sean Coughlin about "Grease," his proposed layer 2 payment channel protocol for Monero. They delve into its technical design, how it compares to Bitcoin's Lightning Network, and its potential to streamline Monero transactions by enabling off-chain payments without routing complexities. Sean shares insights from MoneroKon, discusses Monero's resilience despite theoretical attack vectors, and explains how Grease aligns with upcoming upgrades like Full Chain Membership Proofs (FCMP++). He also touches on real-world use cases, wallet integration, and Grease's flexible, decentralized approach aimed at boosting Monero's usability and innovation. TIMESTAMPS: (00:03:40) Sean's background and involvement in Monero development (00:06:29) Privacy strength of Monero and resistance to chain analysis (00:10:21) Comparisons to other privacy coins (e.g., Zcash) (00:12:26) MoneroKon research papers and Eclipse attacks on nodes. (00:14:35) Discussion on Full Chain Membership Proofs (FCMP++) and its progress. (00:18:37) Clarifying Zero-Knowledge Proofs and Monero's cryptographic foundation. (00:22:11) History and capabilities of Turing-complete ZKPs in other projects. (00:26:16) Philosophy of "minimaxing" – Monero focuses only on privacy. (00:27:19) Debating if Monero needs to become Turing complete. (00:31:05) Introduction to "Grease" – Monero-compatible payment channel proposal. (00:31:42) Technical hurdles for payment channels in Monero (e.g., no transaction chaining). (00:35:01) Feasibility of Grease today vs. post-FCMP++. (00:36:38) Clarifying the benefits and use cases of Grease (instant payments, off-chain privacy). (00:39:39) Why Layer 2 doesn't conflict with Monero's scaling philosophy. (00:46:41) Grease vs. Bitcoin Lightning Network (00:56:05) Feedback from MoneroKon and Reddit – cautious optimism from developers. (01:05:39) Trade-offs: centralization vs. security in protocol design GUEST LINKS: https://x.com/seanrcoughlin Purchase Cafe & tip the farmers w/ XMR! https://gratuitas.org/ Purchase a plug & play Monero node at https://moneronodo.com SPONSORS: Cakewallet.com, the first open-source Monero wallet for iOS. You can even exchange between XMR, BTC, LTC & more in the app! Monero.com by Cake Wallet - ONLY Monero wallet (https://monero.com/) StealthEX, an instant exchange. Go to (https://stealthex.io) to instantly exchange between Monero and 450 plus assets, w/o having to create an account or register & with no limits. WEBSITE: https://www.monerotopia.com CONTACT: monerotalk@protonmail.com ODYSEE: https://odysee.com/@MoneroTalk:8 TWITTER: https://twitter.com/monerotalk FACEBOOK: https://www.facebook.com/MoneroTalk HOST: https://twitter.com/douglastuman INSTAGRAM: https://www.instagram.com/monerotalk TELEGRAM: https://t.me/monerotopia MATRIX: https://matrix.to/#/%23monerotopia%3Amonero.social MASTODON: @Monerotalk@mastodon.social MONERO.TOWN: https://monero.town/u/monerotalkAny donation is greatly appreciated!Any donation is greatly appreciated!

Featuring perspectives from Ms Ilene Galinsky, Dr Michael J Mauro, Dr Neil P Shah and Dr Sara M Tinsley-Vance, including the following topics: Introduction: Chronic Myeloid Leukemia (CML) as a Model for Targeted Treatment (0:00) Biology of CML; Role of First- and Second-Generation Tyrosine Kinase Inhibitors (TKIs) as Initial Treatment for Chronic-Phase (CP) CML (12:37) Role of Asciminib for Newly Diagnosed CP-CML (47:46) Feasibility of TKI Discontinuation for Patients with Sustained Response to Treatment (1:14:06) Management of CP-CML After Failure of Initial Therapy (1:23:04) NCPD information and select publications

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Safety and Feasibility of On-the-Table Pharmacomechanical Lysis for Acute Intermediate-Risk Pulmonary Embolism: The RESCUE-II Study.

In this episode Adam shares a new development in a prospective project, and introduces the idea of a Pre-Design and Feasibility study. 

Creatine for Alzheimer's — let's separate the hype from the hope. A new study has caused a stir in June 2025, but lead researcher Matthew K. Taylor told us: “ I don't think I can recommend it to a patient that this is going to ultimately have some sort of cognitive influence.” We speak to Dr. Taylor and Dr. Russell Swerdlow in this episode, discussing: • Role of creatine in your brain, and why it matters for energy metabolism • What the 2025 study found (and why it wasn't designed to prove effectiveness) • How scientific nuance gets lost in supplement hype • Why even promising early data must be handled with care • The vital difference between hype and hope Dr. Russell Swerdlow, MD is Director of the University of Kansas Alzheimer's Disease Research Center. Dr. Matthew Taylor, PhD, RD is Associate Professor of Dietetics & Nutrition at the University of Kansas Medical Center. This is... Your Brain On Creatine. SUPPORTED BY: NEURO World. Help your brain thrive, now and into the future: https://neuro.world/  ‘Your Brain On' is hosted by neurologists, scientists, and public health advocates Ayesha and Dean Sherzai.  ‘Your Brain On... Creatine' • SEASON 5 • EPISODE 8 LINKS  Dr. Taylor at the University of Kansas: https://www.kumc.edu/mtaylor3.html Dr. Swerdlow at the University of Kansas: https://www.kumc.edu/rswerdlow.html REFERENCES 1. Smith AN, Choi IY, Lee P, Sullivan DK, Burns JM, Swerdlow RH, Kelly E, Taylor MK. Creatine monohydrate pilot in Alzheimer's: Feasibility, brain creatine, and cognition. Alzheimer's & Dementia: Translational Research & Clinical Interventions. 2025 Apr;11(2):e70101. 2. Taylor MK, Burns JM, Choi IY, et al. Protocol for a single-arm, pilot trial of creatine monohydrate supplementation in patients with Alzheimer's disease. Pilot Feasibility Study. 2024;10(1):42.  3. Habeck C, Risacher S, Lee GJ, et al. Relationship between baseline brain metabolism measured using [18 F]FDG PET and memory and executive function in prodromal and early Alzheimer's disease. Brain Imaging Behav. 2012;6(4):568-83.  4. Kreider RB, Kalman DS, Antonio J, et al. International Society of Sports. Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. J Int Soc Sports Nutr. 2017;14:18.

Everyone has goals — some are monumental, others modest — but every goal matters. Join guest Szu-chi Huang, an expert in sustaining enthusiasm for individuals, customers, and employees across global corporations and organizations, as she delves into the science of motivation. Discover how the gap between where you are and where you want to be is bridged by a dynamic blend of psychology, sociology, behavioral economics, neuroscience, and the latest in AI. The secret to achieving your goals? Stay adaptable. If one approach falters, switch gears to keep your drive alive, Huang tells host Russ Altman on this episode of Stanford Engineering's The Future of Everything podcast.Have a question for Russ? Send it our way in writing or via voice memo, and it might be featured on an upcoming episode. Please introduce yourself, let us know where you're listening from, and share your question. You can send questions to thefutureofeverything@stanford.edu.Episode Reference Links:Stanford Profile: Szu-chi HuangConnect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>> Twitter/X / Instagram / LinkedIn / FacebookChapters:(00:00:00) IntroductionRuss Altman introduces Szu-Chi Huang, professor of marketing at Stanford GSB.(00:03:31) Studying MotivationSzu-chi shares what led her to study motivational science(00:04:03) Defining MotivationMotivation as the drive to close the gap between current and ideal self.(00:04:57) The Science of MotivationStudying motivation through behavioral and neurological data.(00:05:48) Why It Matters in BusinessHow motivation science applies to leaders, teams, and customers.(00:06:39) Motivation FrameworkThe strategies needed in order to stay motivated over time.(00:07:42) The Mindset of MotivationThe different mindsets needed throughout the stages of motivation.(00:09:21) Motivating Kids to Choose HealthyA Collaboration with UNICEF to study what motivates children.(00:10:55) Gamified Coupons in PanamaA study using gamified coupons to influence children's food choices.(00:14:26) Loyalty Programs as MotivationHow customer reward programs act as structured goal journeys.(00:16:47) Progress Versus PurposeThe different incentives needed in each stage of loyalty programs.(00:18:29) Retirement Saving LessonsHow financial institutions apply motivational science to long-term goals.(00:21:12) Motivation in Social ContextThe role of social connections in goal pursuit and sustaining motivation.(00:26:10) Designing Apps for MotivationHow redesigning user interfaces can help users stay motivated.(00:27:20) AI as a Motivation CoachUsing AI to personalize feedback across all stages of goal pursuit.(00:30:09) Starting and Sustaining a GoalPractical strategies for launching and sustaining a goal.(00:31:57) Conclusion Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook

This week on The Beat, CTSNet Editor-in-Chief Joel Dunning speaks with CTSNet JANS Editor Dr. Mateo Marin-Cuartas, a cardiac surgeon in the University Department of Cardiac Surgery at the Leipzig Heart Center, Germany, about surgical aortic valve replacement (SAVR) vs transcatheter aortic valve replacement (TAVR). Chapters 00:00 Intro 00:57 Dr. Marin-Cuartas Feature 02:28 SHURUI Robot Feasability 05:09 Touching as Diagnostic Test 09:06 Removal of Rib Stab Hardware 13:00 Resectable EGFR-Positive NSCLC 16:12 On-Pump Beating Heart MVR 17:56 Post-Infarction Myocardial Rupture 19:52 Head-First Graft Technique 22:18 SAVR vs TAVR, Dr. Marin-Cuartas 46:44 Upcoming Events 47:52 Closing They discuss SAVR and TAVR guidelines, the suitability of SAVR vs TAVR for patients aged 65-75, and mechanical heart valves. They also explore surgery after TAVR, TAVR after TAVR, and the future of addressing aortic valve stenosis.   Joel also highlights recent JANS articles on the safety and feasibility of novel single-port robotic-assisted lobectomy/segmentectomy for lung cancer, touching (proximity) as a companion diagnostic test, long-term outcomes after removal of rib stabilization hardware in patients with blunt chest trauma, and advancing the needle on the management of resectable EGFR-positive NSCLC.    In addition, Joel explores an on-pump beating heart mitral valve repair through right anterior minithoracotomy, post-infarction myocardial rupture treated with surgical repair and graded mechanical support, and a head-first graft technique in aortic arch replacement. Before closing, Joel highlights upcoming events in CT surgery.    JANS Items Mentioned  1.) Safety and Feasibility of Novel Single-Port Robotic-Assisted Lobectomy/Segmentectomy for Lung Cancer  2.) Touching (Proximity) as a Companion Diagnostic Test   3.)  Long-Term Outcomes After Removal of Rib Stabilization Hardware in Patients With Blunt Chest Trauma  4.) Advancing the Needle on the Management of Resectable EGFR-Positive NSCLC: Is Neoadjuvant Osimertinib the Answer?  CTSNET Content Mentioned  1.) On-Pump Beating Heart Mitral Valve Repair Through Right Anterior Mini Thoracotomy  2.) Drain, Patch, Unload: Post-Infarction Myocardial Rupture Treated With Surgical Repair and Graded Mechanical Support  3.) Head-First Graft Technique in Aortic Arch Replacement  Other Items Mentioned  1.) Career Center   2.) CTSNet Events Calendar  Disclaimer The information and views presented on CTSNet.org represent the views of the authors and contributors of the material and not of CTSNet. Please review our full disclaimer page here.

Dr. Robert Quartermain, Co-Chairman, Director and CEO of Dakota Gold (NYSE American: DC), joined me for an update on their Richmond Hill Project and Maitland Gold Project, both located in the historic Homestake District of South Dakota, near existing mining infrastructure.   The company is advancing its Richmond Hill project toward eventual surface heap leach gold operation as soon as 2029, and expanding the high-grade gold mineralization discovered at the Maitland Gold Project toward an initial resource estimate.   We start having Robert share his background in the industry, as he was previously the Executive Chairman of Pretium Resources Inc., which he founded in October 2010. Prior to Pretium, he was President and Chief Executive Officer of Silver Standard Resources Inc. (now SSR Mining Inc.) for 25 years from 1985-2010. Not only does he have a wealth of experience in developing and constructing producing mines, but he has assembled a solid management team and board filled with industry veterans that have worked in either the Homestake Mine, before it closed down, or the currently producing nearby Wharf Mine, operated by Coeur Mining.   Richmond Hill is one of the largest undeveloped oxide gold resources in the United States being advanced by a junior mining company, with over 6 million ounces of gold and over 60 million ounces of silver moving along the pathway of development into heap leach production as soon as 2029. Principle Projects on Private Land which equates to a positive attribute for efficient permitting with State and County organizations.   S-K 1300 Mineral Resource (Heap Leachable): 65 M oz M&I Gold, 2.61 M oz Inferred Gold 1 M oz M&I Silver, 22.8 M oz Inferred Silver   Dakota Gold has engaged the current consulting groups based on their capabilities to deliver an Initial Assessment with Cash Flow (IACF) in mid-2025 (similar to a PEA).  This economic study will be based on a 30,000 ton per day crushing circuit, and further the project towards ultimate production. The Company continues Feasibility planning with M3 as the overall Study Manager as well as the lead for processing, while RESPEC will manage the mining and environmental aspects   There are currently two drill rigs turning at Richmond Hill. In 2025, the Company expects to drill ~80,000 feet (24,384 meters) using a combination of Reverse Circulation and Core drilling. The primary focus of the program is to collect metallurgical samples for the Feasibility Study, infill, and expansion resource drilling in the northeast corner of the Project area. This area is expected to be mined at the beginning of the mine plan and is higher-grade than the overall deposit.   At the Maitland Gold Project the Company is currently assessing the exploration data collected to date from the JB Gold Zone and the Unionville Zone with the intent of outlining an initial inferred gold resource. The work is expected to be completed in the fall of 2025. To date the JB Gold Zone has encountered a number of high-grade intersections which average 10.76 g/t Au over 4.0 meters.   With the recent financing announced March 20, 2025, the Company currently has a cash balance of $47 million as noted in the filed 10Q as at March 31, 2025, and is fully financed through the IACF and the subsequent completion of its Feasibility Study on the Project.   If you have any questions for Bob Quartermain regarding Dakota Gold, then please email those in to me at Shad@kereport.com.   In full disclosure, Shad is a shareholder of Dakota Gold at the time of this recording, and may choose to buy or sell shares at any time.   Click here to follow the latest news from Dakota Gold

Can AI and mass timber help solve the housing crisis? In this episode of Constructive, Seth sits down with Seyfihan Usarer — Co-Founder & COO of Algoma — to explore how their startup is transforming the slow, siloed preconstruction process into a fast, transparent decision engine for real estate developers.From feasibility studies powered by zoning-AI and comps to mass timber kits of parts, Seyf shares how Algoma is helping developers go from site to permit with clarity and speed — while keeping carbon footprint in check. They talk housing affordability, startup lessons from McKinsey and TikTok, and why the future of construction is an optimization game.

Send us a textConvergent's Jay Werth and Pam Reid discuss the importance of conducting a feasibility study before launching a capital or comprehensive campaign. Pam emphasizes that feasibility studies provide crucial intelligence for a case for investment development and informed decision-making. She also introduces the IMPACT acronym for case content: Introduction, Mission, Problem, Actual Impact, Call to Action, and Transparency. Pam advises that draft cases should be concise, visually appealing, and tailored to the audience. Curious why Comprehensive Campaigns are a game-changer for nonprofit fundraising? Sign up for updates!

POCUS Journal Podcast Episode 11:“Demonstrating Feasibility of Point of Care Ultrasound (POCUS)-Guided Inpatient Transthoracic Echo Triage Decision Pathway"Guests: Dr. Stephanie Connerand Dr. Mustafa HusainiGuest Editor: Dr. Ritu ThammanDOI: https://doi.org/10.24908/pocusj.v10i01.17776

Summary In this episode of Develop This Podcast, Dennis Fraise interviews Brian Abernathy, General Manager of Convergent Nonprofit Solutions, discussing the importance of revenue benchmarking for Economic Development Organizations (EDOs). They explore how public-private partnerships have become best practices in funding, the methodology behind revenue benchmarking studies, and the significance of analyzing sector representation in funding sources. The conversation emphasizes the need for effective communication and long-term strategies in economic development. Takeaways Convergent specializes in fundraising planning and consulting for nonprofits. Revenue benchmarking helps EDOs understand their funding structure. Public-private partnerships enhance funding opportunities for EDOs. Data analysis reveals unique areas of opportunity for revenue. Diversity in funding sources is crucial for sustainability. Comparative analysis helps EDOs identify gaps in funding. The benchmarking process takes about four to six weeks. Effective communication builds trust with funders over time. Feasibility studies validate funding opportunities for EDOs. Long-term strategies are essential for successful economic development.

Interview with Walter Coles, Executive Chairman of Skeena Resources Ltd.Our previous interview: https://www.cruxinvestor.com/posts/skeena-resources-tsxske-fully-funded-high-grade-gold-poised-for-production-5657Recording date: 29th May 2025Skeena Gold & Silver is developing the Eskay Creek Mine in British Columbia, positioned to become one of the world's largest gold-silver mines when production begins in early 2027. This project represents a compelling investment opportunity with exceptional economics, significant upside potential, and multiple near-term catalysts that could drive substantial share price appreciation.The project's economics are truly remarkable. At $3,200/oz gold price, Eskay Creek boasts an after-tax NPV of $4.5 billion and an extraordinary 72% internal rate of return. This translates to a payback period of just over six months on the $700 million construction cost. Most impressively, Skeena's all-in sustainable cost per ounce is projected at less than $600 for the first six years of production, compared to approximately $1,700 for major producers like Barrick and Newmont. "We have a project that's super super low on the cost curve, enormously profitable per ounce of production.", explains Coles. This cost advantage creates exceptional profit margins even at much lower gold prices.Skeena has secured comprehensive financing through Orion Resource Partners, removing a major uncertainty that typically impacts junior developers. The $750 million package includes equity, a gold stream, and debt facilities. Since announcing this funding, Skeena's stock has nearly tripled from around $6 to $17 Canadian. The company is now exploring refinancing options to reduce its cost of capital as the project de-risks.Beyond the base case, Skeena is advancing several value-enhancement initiatives. The company plans to extend the mine life from 12 to 15-16 years by incorporating the high-grade Snip deposit and the Albino Lake waste facility. Additionally, Skeena has identified significant antimony, lead, and zinc content worth potentially 2.2 million tons of waste tailings that could be recovered with minimal additional costs.Investors can look forward to several near-term catalysts such as final permits expected in Q4 2025, refinancing of the Orion loan facility in Q1 2026, updated feasibility study in the first half of 2026, and production commencement in early 2027.Skeena's partnership with the Tahltan First Nation adds another layer of strength to the project. The company signed the first agreement in Canada giving a First Nation formal consent rights over a mining project, creating a true partnership that reduces social and political risk factors.For investors seeking exposure to precious metals with significant upside potential, Skeena offers a rare combination of exceptional grade, economics, and execution capability in a tier-one jurisdiction. As the company advances toward production and begins generating substantial cash flow, the valuation gap with producing peers is likely to close, potentially delivering substantial returns to investors who position themselves ahead of these developments.View Skeena Gold & Silver's company profile: https://www.cruxinvestor.com/companies/skeena-resourcesSign up for Crux Investor: https://cruxinvestor.com

Join our Patreon and get access to monthly bonus episodes and more nutriton content!Can fasting really slow aging? Does calorie restriction work for humans, or just for mice and yeast? And how much protein do you actually need to age well? This week on Your Diet Sucks, we break down the evidence behind the most talked-about interventions in the longevity space, what holds up under scrutiny, what doesn't, and why you might not need a supplement stack to live longer, and enjoy life. We dig into:The actual science on calorie restriction, fasting, and supplements—and where the evidence stopsWhat inflammation, oxidative stress, and telomeres have to do with how we ageThe best-researched dietary patterns for living longer (hint: it's not sexy, but it might include red wine)Why protein becomes more important as we ageThe difference between lifespan and healthspan, and why quality of life needs to be part of the conversation

The United States and China reached a 90-day truce in the trade war when their representatives met in Geneva in early May. Both sides agreed to temporarily roll back tariffs and non-tariff trade barriers. President Trump announced that a “total reset” in US-China relations had been achieved. Beyond the hyperbole, the two sides agreed to establish a mechanism on economics and trade and launch negotiations to address trade imbalances and other problems. Whether a deal is reached, what it might look like, and what it might include, remains to be seen. The future trajectory of US-China relations, overall, is still unclear.This episode highlights a Chinese perspective on the US-China bilateral relationship, including on the recent trade talks and the factors that will influence US-China relations going forward. Sun Chenghao, a fellow and head of the U.S.-Europe program at Tsinghua University's Center for International Security and Strategy (CISS), and council member of the Chinese Association of American Studies joins host Bonnie Glaser for this episode.  Timestamps[00:00] Start[01:39] What does Trump want from China? [04:29] What view does Dr. Sun hold?[05:00] Assessing the US-China Geneva Talks[09:21] Feasibility of a Broad US-China Trade Deal[13:23] Implications of Trump's “Unification” Comment[16:46] Importance of the Strategic Channel[20:47] Declining America, Rising China[23:27] Shift in US Policy Toward Alliances[27:49] The Future of US-China Relations

What makes a clinical trial site successful when managing complex transplant studies? In this episode of “Moving Medicine Forward,” host Jeremy Schrand is joined by Shawna Bredek, a 20+ year veteran in clinical trial operations, to explore how feasibility assessments shape the future of life-saving research. Shawna shares how her team evaluates sites, navigates post-COVID challenges, tackles regulatory hurdles, and builds lasting relationships that help bring rare disease treatments and transplant innovations to life. Whether you're working in clinical research or simply curious about medical breakthroughs, this episode offers a compelling look at the strategy behind meaningful science.  Show Notes: 00:36 Meet Shawna Bredeck, VP Global Site Activation & Clinical Document Management at CTI 00:52 Feasibility in the context of a clinical trial 01:18 Why choosing the right site and Private Investigator is critical 02:12 Post-COVID challenges: site fatigue, turnover, and timelines 03:34 Sponsors' expectations vs. site realities 04:03 Asking tough feasibility questions upfront 05:17 Transplant-specific logistics: 24/7 coverage and site readiness 05:54 Navigating regulatory red tape across countries 07:28 How regulatory delays can stall important trials 08:12 Global differences: why it's easier to start in Brazil than the US 08:54 Engaging rare disease sites through relationships and reputation 09:56 Partnering with advocacy groups for trial success 10:58 Shawna's proudest career moment: a major transplant drug approval 12:21 The human side of transplant research 12:50 The shared mission of patients, sponsors, sites, and scientists 13:02 Final thoughts and how to connect with CTI 

Here's how I can help you: Courses https://www.dickersoninternational.com/coursesMentorshiphttps://www.dickersoninternational.com/mentorshipConnect with me here: Facebook: https://www.facebook.com/pg/thegregdickersonInstagram: https://www.instagram.com/thegregdickersonLinkedIn: https://www.linkedin.com/in/agregdickersonTwitter: https://twitter.com/agregdickersonYouTube: https://www.youtube.com/user/agregdickerson/?sub_confirmation=1Podcast: https://www.dickersoninternational.com/podcast#realestatedevelopment #realestateinvesting #realestate Greg is a serial entrepreneur, real estate developer, coach and mentor to high level investors around the world. He has bought, developed and sold over $250 million in real estate, built and renovated hundreds of custom homes and commercial buildings, developed residential and mixed-use subdivisions and started 12 different companies from the ground up. Greg currently mentors some of the top entrepreneurs, real estate investors and real estate developers in the country helping them grow and scale their business, raise more capital and do bigger deals. Greg's current clients have over $2 billion in AUM and deals in the process.Greg is an expert on the topics of entrepreneurship, leadership and real estate and is regularly interviewed on some of the top real estate investing and business podcasts today.Greg served in the United States Navy right out of high school and has always been a leader in the community as well as supporting, advising and serving on the boards of several churches, ministries and non-profit organizations. This channel is all about Entrepreneurship, Real Estate Investing and Real Estate Development*Nothing in this video or podcast is meant to be construed as legal or investment advice, it's for entertainment purposes only. The video is accurate as of the posting date but may not be accurate in the future.WATCH OUT FOR SCAMMERS IN THE COMMENTS I do not have a telegram, discord or any tother type of paid group. I will not contact you here or on other platforms. Scammers are using my name and picture. My real profile has a dark background around my name. I will not ask you to contact me, ask you for money or give you any contact info. Do not contact anyone in the comments. PLEASE HELP BY REPORTING AND DELETING ALL THESE SCAMMERS. Thank you!

The practicalities of birthright citizenship being restricted in some states but not others appeared to be a concern of key justices on the US Supreme Court. President Donald Trump has asked the justices to narrow lower court rulings that blocked his executive order limiting automatic citizenship to babies born with at least one parent who's a citizen or permanent resident. Cases and Controversies hosts Greg Stohr and Lydia Wheeler discuss Thursday's arguments and highlight the exchanges that seemed to show the justices are wary of letting Trump start enforcing his restrictions. Do you have feedback on this episode of Cases and Controversies? Give us a call and leave a voicemail at 703-341-3690.

In this episode of Good Morning Liberty, hosts Nate Thurston and Chuck Thompson discuss President Trump's recent speech in Saudi Arabia, highlighting his comments on the Middle East's modernization and peace through negotiation. They also delve into a new book by Jake Tapper and Alex Thompson that reveals concerns about Joe Biden's cognitive decline during his presidency, and discuss the implications of lifting sanctions on Syria. The episode also touches on the role of the media in shaping public perception and foreshadows an upcoming analysis on a new spending bill. (00:00) Introduction (01:25) Trump's Speech and Biden's Mental Decline (03:37) Discussion on Trump's Foreign Policy (07:29) Syria Sanctions and Middle East Diplomacy (18:05) Trump's Speech Highlights (29:28) Interactive Segment and Closing Remarks (30:20) Discussing the Feasibility of Continuing the Podcast (31:04) Introducing the Biden Book Controversy (33:05) Media's Role in Biden's Decline (36:07) Reactions to the Book's Revelations (39:00) Jake Tapper's Involvement and Media Critique (42:32) The White House's Deception and Media's Complicity (49:48) The Future of Media and Political Transparency   Links:   https://gml.bio.link/   YOUTUBE:   https://bit.ly/3UwsRiv   RUMBLE:   https://rumble.com/c/GML   Check out Martens Minute!   https://martensminute.podbean.com/   Follow Josh Martens on X:   https://twitter.com/joshmartens13   Join the private discord & chat during the show!   joingml.com   Bank on Yourself bankonyourself.com/gml   Get FACTOR Today! FACTORMEALS.com/factorpodcast     Good Morning Liberty is sponsored by BetterHelp! Rediscover your curiosity today by visiting Betterhelp.com/GML (Get 10% off your first month)     Protect your privacy and unlock the full potential of your streaming services with ExpressVPN. Get 3 more months absolutely FREE by using our link EXPRESSVPN.com/GML  

In this episode of the California Underground Podcast, hosts Phil and Camille discuss significant political developments in California, focusing on the controversial AB 379 bill aimed at protecting minors from sexual exploitation. They explore Trump's proposal to reopen Alcatraz, the historical context of the prison, as well as hypocritical Democratic politicians like Ted Lieu who claim to be Catholic, yet support ideals that go against Catholic teachings. Are you a Californian who feels isolated and alone in your political views in a deep blue state? Feel like you can't talk about insane taxes, an overbearing government, and radical social experiments without getting a side eye? Then join us on the California Underground Podcast, the most trusted podcast on all things California politics.Original air date  5.6.25*The California Underground Podcast is dedicated to discussing California politics from a place of sanity and rationality.*Chapters04:58 Discussion on Trump's AI Pope Image and Ted Lieu's Reaction11:00 Hypocrisy in Political Statements Regarding Catholicism19:06 Trump's Proposal to Reopen Alcatraz27:19 Exploring the Feasibility of Reopening Alcatraz31:30 In-Depth Analysis of AB 379 and Its Implications37:08 Debating the Age of Consent and Trafficking Laws44:01 Heated Assembly Floor Discussions50:55 The Impact of Public Pressure on Legislation01:01:59 Political Maneuvering and Accountability01:13:35 The Importance of Civic EngagementCheck out our full site for more information about the show at www.californiaunderground.liveCheck out our sponsor for this episode, StopBox, by going to www.stopbox.com/californiaunderground to get 10% off your orderFollow California Underground on Social Media  Instagram: www.instagram.com/californiaunderground X: https://twitter.com/CAUndergoundTik Tok: https://www.tiktok.com/@californiaunderground?_t=8o6HWHcJ1CM&_r=1YouTube: https://www.youtube.com/channel/UCj8SabIcF4AKqEVFsLmo1jA Read about our Privacy Policy: https://www.spotify.com/us/legal/privacy-policy/ 

Dr. Ezra Schwartz (@ezraschwartz10) interviews Dr. Firas Moussa and Mr. Jake Howitt to discuss the IMPROVE-AD Trial, a landmark, multi-institutional study investigating treatment strategies for uncomplicated Type B Aortic Dissection (uTBAD). The IMPROVE-AD Trial is a multicenter randomized trial funded by the NIH/NHLBI that compares thoracic endovascular aortic repair (TEVAR) plus optimal medical therapy (OMT) vs. OMT and surveillance with selective TEVAR in patients with uncomplicated TBAD. The trial aims to address critical gaps in evidence left by prior studies (INSTEAD-XL, ADSORB), with a unique focus on quality of life, cost-effectiveness, and genetic data. Dr. Firas Mussa is a professor and the Chief of Vascular and Endovascular Surgery at McGovern Medical School at UTHealth Houston. He previously served as the Director of the Vascular Surgery Residency and Fellowship programs at NYU Langone Health. Dr. Mussa earned his medical degree from the University of Baghdad, followed by general surgery training at Johns Hopkins University and a vascular surgery fellowship at Baylor College of Medicine. His research focuses on complex aortic pathology, and he serves as the principal investigator of the IMPROVE AD trial. Mr. Jake Howitt is the Community Engagement Co-Chair of the IMPROVE AD trial and a leading patient advocate within the PCORI-funded Aortic Dissection Collaborative. As a survivor of aortic dissection, he is passionate about improving patient-provider communication and raising awareness of hereditary aortic disease. His work emphasizes the importance of education, empathy, and community-building in clinical research and care delivery. Special thank you to Jacob Soucy (@JacobWSoucy). Resources: ·       Treatment of Uncomplicated Type B Aortic Dissection: Optimal Medical Therapy vs TEVAR + Optimal Medical Therapy- https://journals.sagepub.com/doi/10.1177/15385744231184671?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed  ·       INSTEAD Trial - https://pubmed.ncbi.nlm.nih.gov/19996018/ ·       INSTEAD-XL 5-Year Follow-Up - https://pubmed.ncbi.nlm.nih.gov/23922146/ ·       ADSORB Trial - https://pubmed.ncbi.nlm.nih.gov/24962744/ ·       Feasibility of a proposed randomized trial in patients with uncomplicated descending thoracic aortic dissection: Results of worldwide survey - https://pubmed.ncbi.nlm.nih.gov/27823685/ ·       Treatment of AD: Meta-Analysis - https://pubmed.ncbi.nlm.nih.gov/29066151/ ·       TEVAR vs Medical Therapy- https://pubmed.ncbi.nlm.nih.gov/36334259/ ·       IMPROVE AD Trial website - https://improvead.org ·       John Ritter Foundation for Aortic Health - https://johnritterfoundation.org ·       Think Aorta US - https://thinkaorta.us   Follow us @audiblebleeding Learn more about us at https://www.audiblebleeding.com/about-1/ and provide us with your feedback with our listener survey.  *Gore is a financial sponsor of this podcast, which has been independently developed by the presenters and does not constitute medical advice from Gore. Always consult the Instructions for Use (IFU) prior to using any medical device.      

“Everyone's brain is extremely heterogenic, so it's different. You can put five of us in a room; we can all have the same diagnosis of a [glioblastoma multiforme], but all of ours can be different. They're highly aggressive biologically. It's a small area in a hard shell. So trying to get through the blood–brain barrier is different. There's a lot of areas of hypoxia in the brain. There's a lot of pressure there. The microbiology is very different—it's a cold environment versus a hot environment—and then the pathways are just different,” Lori Cappello, MSN, APN-C, CCRP, research advanced practice nurse at the John Theurer Cancer Center of Hackensack Meridian Health in New Jersey, told Jaime Weimer, MSN, RN, AGCNS-BS, AOCNS®, manager of oncology nursing practice at ONS, during a conversation about brain malignancies and caring for patients with them. Music Credit: “Fireflies and Stardust” by Kevin MacLeod Licensed under Creative Commons by Attribution 3.0  Earn 0.5 contact hours of nursing continuing professional development (NCPD) by listening to the full recording and completing an evaluation at courses.ons.org by April 25, 2027. The planners and faculty for this episode have no relevant financial relationships with ineligible companies to disclose. ONS is accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center's Commission on Accreditation. Learning outcome: Learners will report an increase in knowledge related to brain malignancies and their diagnosis and treatment. Episode Notes  Complete this evaluation for free NCPD.  ONS Podcast™ episodes: Episode 235: Self-Advocacy Skills for Patients Episode 166: Cognitive Behavioral Interventions Help Patients With a Spectrum of Cancer Symptoms ONS Voice articles: Glioblastoma Diagnosis, Treatment, Side Effect Management, and Survivorship Recommendations Blocking Fatty Acid Storage May Induce Glioblastoma Apoptosis Brain Tumor Navigator Role Bridges the Intersection of Cancer and Neuroscience Researchers Tie More Cancers, Mortality to NF1 Disorders Larotrectinib and Other Tumor-Agnostic Targeted Therapies Are Leading Cancer Care Into the Next Frontier McCain Announcement Sheds Light on Nurses' Role in Advance Care Planning ONS book: Manual for Radiation Oncology Nursing Practice and Education (fifth edition) Clinical Journal of Oncology Nursing articles: Implementing a Standardized Educational Tool for Patients With Brain Tumors Undergoing Concurrent Temozolomide and Radiation Therapy Exercise Intervention: A Pilot Study to Assess the Feasibility and Impact on Cancer-Related Fatigue and Quality of Life Among Patients With High-Grade Glioma Society for Neuro-Oncology Musella Foundation End Brain Cancer Initiative Brain Tumor Network American Brain Tumor Association Glioblastoma Research Organization Brain Tumor Funders' Collaborative Optune Gio® website Nurse.org article: Mysterious Brain Tumor Cluster Grows: Another Nurse Diagnosed at Newton-Wellesley Lori Cappello's contact information: lori.cappello@hmhn.org To discuss the information in this episode with other oncology nurses, visit the ONS Communities. To find resources for creating an ONS Podcast Club in your chapter or nursing community, visit the ONS Podcast Library. To provide feedback or otherwise reach ONS about the podcast, email pubONSVoice@ons.org. Highlights From This Episode “A glioblastoma actually is the most predominant brain tumor that we do see. It is the most diagnosed of the brain tumors. And then I would say that an anaplastic astrocytoma is probably the second diagnosed. Historically a GBM, they used to say was probably an elderly patient for these. But we are definitely seeing it diagnosed at a much younger age now, definitely much more prevalent for people under 60.” TS 3:17 “Nine times out of ten, either a patient out of nowhere has a seizure, or they present with what they think are stroke-like symptoms. They noticed that they were slurring, or they were becoming more forgetful, or a family member noticed it and said, ‘Hey, what is going on with you?' But usually they present to the [emergency department], and a [computed tomography] scan is always done first. And lo and behold, something is seen.” TS 4:50 “The only other U.S. Food and Drug Administration-approved treatment that has come along in the last 20 years is a device called Optune Gio, which is an alternating electric field that stops cell division at the mitosis stage.” TS 7:45 “They lose so much of their independence, especially if they don't have a caregiver or help. That is huge. Medication management at home, to making sure that they're taking the medication properly, that they are actually taking their medication. Transportation is another huge problem. Getting to and from appointments is a challenge. Those are big issues—real, day-to-day, simple issues that people don't think about.” TS 17:11 “I think that having a brain tumor is very unique in the fact that you really need a dedicated neuro-oncologist. And depending on where you live, there are not a lot in the area. I actually had a patient that was moving out west, and the closest dedicated neuro-oncologist was four hours from them. … if you're not seeing dedicated neuro oncologists, you might not be getting the best treatment for yourself. So I think that having the resources and helping patients find the best care or the best brain tumor society—and there's a bunch of really good brain tumor groups to help patients find the best resources out there. I think that's really, really important for patients to know or for families to know.” TS 19:17 “So trying to help patients, there are always going to be challenges, and there are always going to be ups and downs. But finding that one person that they can go to, that they trust, that they have a great relationship with, whether at the doctor's office or whatever, and being available to them makes such a difference in their journey. I think that that is the most important for anybody in the journey.” TS 22:08 “With brain, there are going to be expectations. They are going to lose functionality at some point—and preparing them for that thing or preparing them for things that can help themselves. Like sometimes I say, ‘Go to the dollar store, get coloring books,' if they have weakness in one hand. Little tricks of the trade that can help them. About treatment options, going through the side effects, preparing them for whatever they can be prepared for.” TS 22:39 “It is not one of the better cancers to have, but it doesn't immediately mean it's a death sentence, and we shouldn't treat them like they're dying. We shouldn't take away their ability to live just because they were diagnosed with it. We shouldn't take away hope.” TS 25:35 “I think there's not enough discussed about [brain malignancies] and the lack of resources for this. These patients need a lot more resources and are available. There's just not enough available for it.” TS 26:59

Feasibility and acceptability of a six-month exercise and patient education intervention for patients with hip dysplasia: A mixed methods study Jacobsen JS, Thorborg K, Sørensen D, et al. Musculoskelet Sci Pract. 2022;61:102615. doi:10.1016/j.msksp.2022.102615 Due to copyright laws, unless the article is open source we cannot legally post the PDF on the website for the world to download at will. Brought to you by our sponsors at: CSMi – https://www.humacnorm.com/ptinquest Learn more about/Buy Erik/Jason/Chris's courses – The Science PT Support us on the Patreons! Music for PT Inquest: “The Science of Selling Yourself Short” by Less Than Jake Used by Permission Other Music by Kevin MacLeod – incompetech.com: MidRoll Promo – Mining by Moonlight Koal Challenge – Sam Roux

Notes from James: What if I told you that we could eliminate the IRS, get rid of personal income taxes completely, and still keep the government funded? Sounds impossible, right? Well, not only is it possible, but historical precedent shows it has been done before. I know what you're thinking—this sounds insane. But bear with me. The IRS collects $2.5 trillion in personal income taxes each year. But what if we could replace that with a national sales tax that adjusts based on what you buy? Under my plan: Necessities (food, rent, utilities) 5% tax Standard goods (clothes, furniture, tech) 15% tax Luxury goods (yachts, private jets, Rolls Royces) 50% tax And boom—we don't need personal income taxes anymore! You keep 100% of what you make, the economy booms, and the government still gets funded. This episode is a deep dive into how this could work, why it's better than a flat tax, and why no one in government will actually do this (but should). Let me know what you think—and if you agree, share this with a friend (or send it to Trump). Episode Description: What if you never had to pay personal income taxes again? In this mind-bending episode of The James Altucher Show, James tackles a radical idea buzzing from Trump, Elon Musk, and Howard Lutnick: eliminating the IRS. With $2.5 trillion in personal income taxes on the line, is it even possible? James says yes—and he's got a plan. Digging into history, economics, and a little-known concept called “money velocity,” James breaks down how the U.S. thrived in the 1800s without income taxes, relying on tariffs and “vice taxes” on liquor and tobacco. Fast forward to today: the government rakes in $4.9 trillion annually, but spends $6.7 trillion, leaving a gaping deficit. So how do you ditch the IRS without sinking the ship? James unveils his bold solution: a progressive national sales tax—5% on necessities like food, 15% on everyday goods like clothes, and a hefty 50% on luxury items like yachts and Rolls Royces. Seniors and those on Social Security? They'd pay nothing. The result? The government still nets $2.5 trillion, the economy grows by $3.7 trillion thanks to unleashed consumer spending, and you keep more of your hard-earned cash. No audits, no accountants, just taxes at the cash register. From debunking inflation fears to explaining why this could shrink the $36 trillion national debt, James makes a compelling case for a tax revolution. He even teases future episodes on tariffs and why a little debt might not be the enemy. Whether you're a skeptic or ready to tweet this to Trump, this episode will change how you see taxes—and the economy—forever. What You'll Learn: The history of taxes in America—and how the country thrived without an income tax in the 1800s Why the IRS exists and how it raises $2.5 trillion in personal income taxes every year How eliminating income taxes would boost the economy by $3.75 trillion annually My radical solution: a progressive national sales tax—and how it works Why this plan would actually put more money in your pocket Would prices skyrocket? No. Here's why. Timestamps: 00:00 Introduction: Trump's Plan to Eliminate the IRS 00:22 Podcast Introduction: The James Altucher Show 00:47 The Feasibility of Eliminating the IRS 01:27 Historical Context: How the US Raised Money in the 1800s 03:41 The Birth of Federal Income Tax 07:39 The Concept of Money Velocity 15:44 Proposing a Progressive Sales Tax 22:16 Conclusion: Benefits of...