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Episode 269- The Nightmare Before Christmas Also Available OnSearchable Podcast Transcript Gun Lawyer — Episode 269 Transcript SUMMARY KEYWORDS Second Amendment, New Jersey Democrats, gun laws, machine gun conversion devices, digital instructions, firearm components, gun owner gulag, cash bail, pre-trial detention, carry killer bill, sensitive places, gun rights, constitutional rights, gun lawyer. SPEAKERS Evan Nappen, Speaker 2, Teddy Nappen Evan Nappen 00:15 I’m Evan Nappen. Teddy Nappen 00:17 And I’m Teddy Nappen. Evan Nappen 00:19 And welcome to Gun Lawyer. So, the New Jersey Democrats are going to give gun owners a Nightmare Before Christmas. What they are doing is pushing a package of Second Amendment oppression upon us, and they decided that the perfect time to do it is right before Christmas. On Monday, December 22, the Senate will be having a voting session. They’re going to be looking at bills that we’re going to talk about right now, and you need to take action. You know, you need to let the legislators know that you oppose this. Hopefully you belong to the Association of New Jersey Rifle & Pistol Clubs. If not, you need to join. That’s anjrpc.org. They send out the news releases where you can immediately take action and let the legislature know your feelings on their oppression of our Second Amendment rights as they continue to attack them. Evan Nappen 01:33 Now, we have some very problematic laws that they’re going to be trying to jam through, and I want to make sure that you’re aware of what they are and what they mean. So, we have what is A-4974, and its companion in the Senate is S-3893. (https://www.njleg.state.nj.us/bill-search/2024/S3893) This bill establishes criminal penalties for sale and possession of machine gun conversion devices. Now, of course, these things are already banned. They’re already banned under federal law and state law, but New Jersey just can’t ban something enough, right? So, they’re just duplicating here even more bans upon bans. This is supposedly addressing so-called Glock triggers, but New Jersey usually finds a way to expand it to all kinds of other nonsense. We’ve seen these things lead off into false charges over devices that are not designed to convert to machine guns, but instead designed to simply improve accuracy and a trigger or those kind of things. So, these things are just problematic, and they’re just putting bans on top of bans. And they just want to make sure their name is on a piece of law where they’re “doing something about it”. You know, to sell red meat to their base. So, we have that to deal with. Page – 1 – of 10Evan Nappen 03:16 Additionally, we have A-4975 and the Senate companion bill is S-3894. (https://www.njleg.state.nj.us/bill-search/2024/A3894) This bill establishes a crime of possessing digital instructions to illegally manufacture firearms and firearm components. Now, keep in mind, back in 2018 Murphy signed a law banning the use and sale these digital files already, but this bill is even worse. The mere possession of the files will result in incredibly harsh penalties, even if you unknowingly possess them on a long forgotten computer, etc. So, New Jersey is turning firearm information, pure firearm digital information, into the equivalent of possessing child pornography. Simple possession of the digital file itself. Evan Nappen 04:20 It doesn’t matter that you never had any intention to actually build a firearm, but this gun information is itself being turned into contraband. Now, of course, this brings in First Amendment issues as well as Second Amendment issues, and I’m sure this will as well be subject to challenge. But nonetheless, it puts gun owners at risk that utilize internet and such for downloads of different things. Strictly for informational purposes. Even though you had no intent to 3D print a gun or not, or to use it with a CNC machine to make guns or even gun parts. So, this bill is another oppression of Second Amendment rights, and this time an oppression of First Amendment rights. But since when do Democrats care about rights? So, you need to oppose this as well. Evan Nappen 05:25 There is another bill, Assembly 4978, and the Senate companion is 3897. (https://pub.njleg.gov/Bills/2024/S4000/3897_I1.HTM) Now, this bill requires the Attorney General to report data regarding shootings that did not result in bodily injury. This type of data accumulation is used so then they can twist it into political fodder to further pass other Second Amendment oppression laws. This is their game. So, this is a step in, you know, focusing on the potential discharge law, making accidents into crimes, and using it to become automatic licensing disqualifiers, what become essentially per se felonies. This is how their evil works. This is what they do. This is their machinations, and this is the beginnings of them laying the groundwork to do that very thing. We’ve seen this playbook before, as they put data together that they then abuse in the manner that suits their purposes. So, of course, we have to fight this. Evan Nappen 06:53 Another incredibly serious other bill that’s in the Nightmare Before Christmas is Assembly 4981. The companion is S-3900. (https://www.njleg.state.nj.us/bill-search/2024/A4981) Now, this bill is a Gun Owner Gulag enhancement bill. This law will take the Gun Owner Gulag and make it even worse. So, as you should be familiar, but I want to make sure you are, New Jersey has the Gun Owner Gulag, which is New Jersey’s elimination of cash bail. In getting rid of cash bails, like so many progressive blue states took those actions to do that in the specifically during the, you know, defund police movement and all that. You normally hear about the cashless bails being utilized, where actual criminals, bona fide bad guys, you know, rapists, murders, etc, are put in a revolving door and released very quickly out in the street, particularly if they have other characteristics that the Left is favoring, such as being, you Page – 2 – of 10know, illegally in the country and things like that. They want those people out fast. So, it gets used in that way. Evan Nappen 08:15 But when it comes to weaponization of it against gun owners, well, that’s a different story. They want to imprison us. Okay? So they want to make sure that any gun owner that has a problem, well, they’re going to be subject to the Gulag, where they’re going to be held without bail until their trial, because there is no more bail in New Jersey. And what happens is the prosecutor seeks what is called pre-trial detention. And if pre-trial detention is granted, you’re going to sit in jail, having been proven guilty of nothing, until your trial, and that can be months or years. So, this is the Gulag, and that’s how it operates. Well, that’s bad enough. We fight these Gulag cases all the time, trying to get gun owners out because just about any gun offense is a felony level. New Jersey calls them crimes, and they’re normally warrant offenses. You get arrested and then you’re put through the Gulag where you’re held for 48 hours while the prosecutor decides whether to seek pre-trial detention or not. Evan Nappen 09:20 And their policies are, generally, in every gun case, they seek the Gulag, which is to hold you without bail. So, you’re going to be held at least, normally, another five days before your hearing, where your attorney will finally get to argue to get you out. And if your attorney is not successful in doing that, you are staying in with no bail. Well, this bill is an enhancement to that. It will allow the court to take even more time on any firearm offense where they get to hold you for yet another seven days, so that an operability report can somehow be provided regarding the operability of a firearm, which is often irrelevant to the criminal charge, especially in New Jersey. Operability is not even necessarily required for a firearm conviction, but here the abuse of it will be added into the Gulag’s initial holding of the gun owner. So, now you’re going to be arrested on the warrant charge on whatever the allegation of the firearm offense is, even though you’re innocent, it won’t matter. It’s a gun offense. So, the 48 hours, the prosecutor by way of their policy is going to hold you seeking pre-trial detention. Then that pre-trial detention hearing has to get scheduled within, arguably, five days, and normally it’s about that, five days, before you have the hearing. Evan Nappen 10:57 But if we get to that hearing and they say, oh no, we want another seven days, at least, here the seven days to get an operability report. So, now you’re going to be in jail for approximately two weeks, two weeks, without bail, because there is no bail. And that’s just to get you to the hearing so your attorney can try to argue to defeat the prosecutor’s motion for pre-trial detention. And they’re going to now throw this into the mix. So, you can figure with any gun arrest, you know, you’re falsely accused of being in a “sensitive place” or you’re falsely accused of possession of an assault firearm, or you’re falsely accused of unlawful possession of your handgun. You know all kind of false charges and gun rights oppression that I deal with all the time in practice. Well, you’re going to be at least two weeks in jail now before we can even get you out so we can fight the charge that will eventually get you acquitted of. Isn’t that cute? And that’s if your attorney knows how to get you out and succeeds in doing so. Because if not, you’ll just sit in jail until your trial to finally prove that. So, this is the just horrible addition to the Gun Owner Gulag. Page – 3 – of 10Evan Nappen 12:20 These bills need to be fought, and they need to be fought vigorously. Make sure you make your voices heard. Make sure you belong to ANJRPC, the Association of New Jersey Rifle & Pistol Clubs. They have a full-time paid lobbyist. They have a vigorous process here trying to fight this, but of course, we’re dealing with a state where it is a tremendous battle for the forces of constitutional rights protection. Here to succeed, it’s a difficult, challenging environment, but we have to keep up the fight. We have to make our voices known, and we can make changes. As a matter of fact, that Gulag bill, the Association was able to change the original form where it was an indefinite amount of time until they finally got the report. At least it’s been modified to a mere seven days extra. So, now it’s only two weeks in jail, guilty of nothing. Simply because you lawfully exercised your rights in New Jersey. So, these laws are terrible. They are more oppression from our oppressors. We need to fight it and make sure you do. Evan Nappen 13:44 Now, on a little bit of a Christmas gift here, despite the nightmare that the New Jersey Democrats are placing upon us. I do want to mention that thanks to President Trump and his appointment of judges throughout the land, not the least of which, of course, is the Supreme Court, getting three conservative constitutionalist judges there. But also his ability to add to the judges of the Third Circuit Court of Appeals. And because of President Trump particularly adding the last two judges that are constitutional judges that understand the significance of the Second Amendment, the full panel of 14 judges has agreed to hear the appeal in the Siegel versus Platkin, which is the Carry Killer lawsuit that challenges all these sensitive places and the other onerous restrictions that were put forward in the Carry Killer bill. And as you may know, the initial appeal with the three-judge panel, the three-judge panel that had ruled not tremendously in our favor, has been wiped out, wiped out. Now, the full panel of 14 judges are going to hear and decide the Carry Killer bill. This is very good news for us. Evan Nappen 15:26 This is something that makes me cautiously optimistic that we’re going to see some protection and our Second Amendment rights enforced, and it’s very, very important. Of course, New Jersey fought tooth and nail to try to stop the full panel from granting the en banc full panel, but the Association, particularly my good friend and colleague, Dan Schmutter, was successful here in having that full panel take the case. So, this will also bode well, because by getting a decision that knocks out most, if not all, of the Carry Killer bill, it’ll also lay the groundwork for the Supreme Court of the United States. If we start getting split decisions in the circuits over these sensitive place gambit that the Second Amendment oppressionists have pulled after Bruen to try to limit our rights, we may, in fact, see even a national case killing it permanently for the country. But here in New Jersey, we stand in good stead at the moment. Evan Nappen 16:47 Keep in mind that, at the moment, where can you carry and what are the categories where you can and can’t carry right now, at the current state. Remember, you cannot lawfully carry, even with a New Jersey carry permit, within 100 feet of a public gathering, demonstration or event requiring a Government permit. You’re still barred from zoos, parks, beaches, recreational facilities or areas owned or controlled by the state, county or local government unit designated as a gun-free zone. Publicly Page – 4 – of 10owned or leased libraries or museums. Bars or restaurants where alcohol is served and any other sites or facilities where alcohol is sold for consumption on the premises. Entertainment facilities. Casinos and related facilities. And healthcare facilities. Evan Nappen 17:41 Now you currently can lawfully carry with a New Jersey carry permit, of course, while this appeal is not resolved. These things are still blocked, though, and you’re able to carry, and this isn’t a complete list. But essentially in vehicles. As you may recall, the carjacker protection law that was built into the Carry Killer law, saying that you couldn’t have your loaded gun on your person in your vehicle. That is still blocked, and we are, we may carry in our vehicle, in that manner. Private property open to the public is no longer and still is not a sensitive place. In public film locations, we are able to carry. Additionally, the ruling is still in effect blocking the insurance requirement. As you may recall, at some point, Murphy issued an Executive Order banning the sale of so-called murder insurance, where you had gun owner protection programs, and then proceeded in the Carry Killer bill to mandate by law that you get actual murder insurance. Meaning insurance if someone commits an intentional act with a firearm, essentially murdering somebody. That’s been blocked. So, we don’t have to have insurance to have a carry license. And blocking certain permit procedures and requirements that were more administrative in nature. Evan Nappen 19:23 So, this is where we’re standing. But the good news is, with the full panel reviewing it, I’m very excited to see that outcome, and so should you. So, there is still hope. There is hope that the judiciary is going to speak for our rights, and that same full panel will be also considering New Jersey’s magazine ban and so-called assault firearm ban. So we are hopeful for some very good outcomes here, and we’ll keep you informed here on Gun Lawyer. Evan Nappen 20:07 Let me also mention our good friends at WeShoot. That’s where Teddy and I both shoot and where we get our training. And you will love WeShoot. WeShoot is a great indoor range right in Lakewood, conveniently off the Parkway. They constantly run great sales, and they have great service, a fantastic pro shop and a state of the art range, great training. I really can’t give it high enough praise. We love WeShoot, and so will you. Check out WeShoot at weshootusa.com. They have a great website with beautiful photographs. And you don’t want to miss the WeShoot girls that are there posing with some of the finest guns that you will ever see. So, make sure you go to WeShoot and take advantage of that fantastic resource for gun owners, right in New Jersey. Evan Nappen 21:11 And let me also shamelessly plug my book, which is New Jersey Gun Law, the Bible of New Jersey gun law. Make sure you get the book, folks. You need this book. It is the guidebook to keeping you safe, out of jail and not committing GOFUs in New Jersey. It’s 120 topics, all question and answer. It fills you in so you will know what the law is. It is the guidebook used by thousands and thousands of gun owners throughout New Jersey. You can get your copy today by going to EvanNappen.com. EvanNappen.com. Hey, Teddy, what do you have for us today? Page – 5 – of 10Teddy Nappen 21:56 Well, one of the things you know, it’s the holidays, Christmas, and everything’s coming along, and all the wins that have been coming through, and all the crazy insanity that you’ve described. I always think back to the show that you introduced me to, Paladin. There’s a particular episode, I think it was even the Christmas episode where Paladin is there. It’s a whole deal with the fan, like, there’s a small, I think it’s like a house living out there. And the ending line to the whole episode is, it’s Christmas. He’s saying to the guy, it’s Christmas. This is the, this is the one day of the year where we pretend there’s no evil. And that kind of sticks with me in the idea of this is supposed to be the time spent with family, and particularly, we can pretend and not think about all the anti-gun jerks and the gun rights oppressors. This is the time to enjoy Christmas movies, particular ones that involve firearms. So, as I was scanning through the internet, I saw one, I love this article, the top 10 Christmas movies with guns. (https://blog.cheaperthandirt.com/top-10-christmas-movies-with-guns/) Hey. Evan Nappen 23:17 So, that is what Christmas should be about. Guns. Teddy Nappen 23:22 Yeah, exactly. And to start things off, of course, they go with the most controversial one, which is Die Hard. Evan Nappen 23:31 Which we will agree is a Christmas movie. Teddy Nappen 23:35 Correct. I’ve heard all the debates. Evan Nappen 23:37 Ho, ho, ho. I have a machine gun. How does it get any less Christmas than that. Teddy Nappen 23:42 And quite simply, it’s not Christmas without Hans Gruber falling off the Nakatomi building. Evan Nappen 23:49 Yeah, and you know what gun he had, right? Teddy Nappen 23:55 So, well, you had Bruce Willis with his Beretta 92 with the focus. Evan Nappen 24:01 Of course. Teddy Nappen 24:02 But there’s also the MP 5. Page – 6 – of 10Evan Nappen 24:05 Yippie IA, Yippie Ki A. Teddy Nappen 24:08 And the P7 M13s. Evan Nappen 24:12 P7 that what Hans there, I believe, had. Teddy Nappen 24:17 Correct. And it was very good gun play in that part, where he’s no bullets, and it tricks him. The next one, this is actually, it’s one of those where it’s like, what the heck is this movie? I had to watch it, though. I think you were there when we watched Fat Man. Evan Nappen 24:36 Oh god, yeah. Teddy Nappen 24:37 It is probably the funniest, like, weirdest film you could watch. We have Mel Gibson and is this whole plot to murder Santa Claus. It’s him fighting, fighting Boyd Crowder from Justified. Walter Goggins. Crazy gun play between a 1911 and the fat man using a Colt Walker. Evan Nappen 25:06 Yep, definitely. It’s an entertaining film. Teddy Nappen 25:12 Yeah, it’s just one of those. I was like, okay, interesting. Now, this is technically Kiss, Kiss, Bang, Bang, which is a Christmas heist of a film. I don’t know if you ever saw it. With Robert Downey, Jr. Evan Nappen 25:26 I may have. Teddy Nappen 25:27 Kind of an action comedy. They’re carrying their Vector CP One. Evan Nappen 25:34 Oh, Vectors are in it. Huh, okay. Teddy Nappen 25:35 Yeah. And, of course, another HK P7. It’s kind of one of one of those, you kind of spot there. But I was like, I didn’t realize it involved Christmas. Page – 7 – of 10Teddy Nappen 25:44 The one I will highlight, though I always thought was funny, he put on Home Alone, one and two. Here’s the reason. Because, remember, the kid, he plays that clip, the black and white movie where he keeps. Evan Nappen 25:44 Well, you know, the P7 used to be the pistol of the New Jersey State Police, but they had over 40 accidental discharges with it, and they gave it up. And that’s because, although it was marketed as being one of the safest guns, the problem is, it’s a front squeeze that cocks the gun, when you squeeze the front. Unlike a 1911 that has a safety on the back, this squeeze cocks from the front. And the problem is, if you, if you’re not practiced and trained well enough, when you draw the gun out of a holster, you’re cocking it as you pull it out, and that creates a situation that is not exactly the safest situation to be in. There were numerous ADs with that gun. So, something to keep in mind. I think they’re cool and a very interesting design, but I remember seeing Superintendent Pagano talking about it. And he basically said, hey, look, it’s not the gun’s fault. He’s blaming his men. How nice of him. Yeah, right. So that was that episode of the gun, in theory, seeming like it may have been one of the safest guns, but in reality, it was prone to needing a lot of training to make sure that you didn’t cock it until you were ready to. So, there you go. Evan Nappen 27:36 Oh yeah. Teddy Nappen 27:36 The bad guys, oh yeah, yeah. Well, I believe you, but my tommy gun don’t. And it’s like, you’ve been smooching with everybody. Snuffy, Dale, Leo, Little Mo with the gimpy leg, Bony Bob, Cliff, and the guy thinks he’s actually like sleeping with all these individuals. Evan Nappen 27:58 Great. Teddy Nappen 27:59 Yeah. The Thompson 1921 AC sub machine gun. The actual movie is Angel With Filthy Souls. Evan Nappen 28:08 Hmm huh. Okay. Teddy Nappen 28:11 Yeah. Evan Nappen 28:11 So, that was actually a clip from an actual movie? Teddy Nappen 28:14 Yeah, that was funny. And, of course, The Christmas Story with the Red Ryder BB gun. Page – 8 – of 10Evan Nappen 28:20 Oh, the classic of all classics. And in New Jersey, that’s a firearm. It’s not a BB, you know? It’s not just a little old BB gun. There it is, bona fide, defined as a firearm. Teddy Nappen 28:32 Yeah. And they threw in some honorable mentions, like White Christmas. Where it takes, the start is at the Battle of the Bulge. So, you have the M1 Garand coming into play of that. And then. Evan Nappen 28:46 As Patton said, the greatest battle rifle ever devised. Teddy Nappen 28:51 I’d agree. And then you have Scrooged with Santa wielding the XM 556 mini gun. Evan Nappen 29:00 Okay. Teddy Nappen 29:02 And then also Bill Murray with his, remember, he had a stainless snub nose revolver because he’s freaking out that a ghost is there. Evan Nappen 29:10 Okay, yeah. Teddy Nappen 29:12 They couldn’t determine that. Evan Nappen 29:14 He didn’t do much with him and guns, but yeah. Unless it’s some gun for taking out ghosts, right? Ghost Busters. Teddy Nappen 29:22 Oh, and of course, our Majesty’s Secret Service, James Bond and Christmas, what more could you want? With his Walther PPK. Evan Nappen 29:33 Oh yeah, James Bond sometimes had some screwy gun stuff. I remember in one of them where he has an AR7, and the guy’s talking about. And it’s a 25 caliber AR. I’m like, it’s not 25. It’s 22. But hey, what do they know? Teddy Nappen 29:52 Yeah, it’s, this is just a fun list, and it’s something I just kind of like, wow, I didn’t really consider some of these as, like, Chrismas movies. But I guess so. Page – 9 – of 10Evan Nappen 30:03 Well, as long as it has guns in it, we’ll declare them to be Christmas movies. Teddy Nappen 30:08 Fair enough. If it has a gun and it’s a Christmas movie, that’s it. Evan Nappen 30:11 That’s it. That’s the standard from now on. From now on, that’s the standard. Teddy Nappen 30:16 There you go. Evan Nappen 30:17 Oh, that’s good stuff, Teddy. And soon we’ll be enjoying Christmas guns. That’s the deal. That’s the deal. Hey, it is very important that we discuss this week’s GOFU, which is the Gun Owner Fuck Up. These are mistakes that actual clients make that causes them problems, expensive problems. You get to learn for free. And this week’s GOFU is about printing. And I don’t mean printing with your computer printer. I mean about your gun showing when you’re carrying concealed. Now, in New Jersey, it’s not illegal to print. Believe it or not. A gun has to be concealed, but it doesn’t address printing while concealed. However, in New Jersey, you don’t want to print. Because not only do we need to carry concealed, but you want to keep that concealment private and secret. Evan Nappen 31:20 New Jersey is loaded with all kinds of people that are scared of guns, aren’t used to guns, and they can end up calling police because they think someone’s carrying a gun. And next thing you know, even though you’re legal to carry. You also give away tactical advantage, if people can make you as carrying. And this is an issue where individuals can make false accusations against you if they believe that you’re carrying. So, you want to make sure you don’t print when you conceal carry in Jersey. Make sure you are as discrete as possible. Also, you don’t want to inadvertently end up in a sensitive place and have a gun identified on you because you’re printing. You shouldn’t be in a sensitive place, but if you’re printing and in a sensitive place, then you’re going to have a bigger problem. So, be very conscientious when you carry, whether or not you’re printing, or whether your method of carry allows for inadvertent display of your firearm, even for a moment, because you want to stay discrete. You want your concealed carry to be concealed carry, and ultimately that gives you, if nothing else, a tactical advantage of surprise should you need your gun. Evan Nappen 32:51 This is Evan Nappen and Teddy Nappen reminding you that gun laws don’t protect honest citizens from criminals. They protect criminals from honest citizens. Speaker 2 33:01 Gun Lawyer is a CounterThink Media production. The music used in this broadcast was managed by Cosmo Music, New York, New York. Reach us by emailing Evan@gun.lawyer. The information and opinions in this broadcast do not constitute legal advice. Consult a licensed attorney in your state. Page – 10 – of 10 Downloadable PDF TranscriptGun Lawyer S3 E269_Transcript About The HostEvan Nappen, Esq.Known as “America's Gun Lawyer,” Evan Nappen is above all a tireless defender of justice. Author of eight bestselling books and countless articles on firearms, knives, and weapons history and the law, a certified Firearms Instructor, and avid weapons collector and historian with a vast collection that spans almost five decades — it's no wonder he's become the trusted, go-to expert for local, industry and national media outlets. Regularly called on by radio, television and online news media for his commentary and expertise on breaking news Evan has appeared countless shows including Fox News – Judge Jeanine, CNN – Lou Dobbs, Court TV, Real Talk on WOR, It's Your Call with Lyn Doyle, Tom Gresham's Gun Talk, and Cam & Company/NRA News. As a creative arts consultant, he also lends his weapons law and historical expertise to an elite, discerning cadre of movie and television producers and directors, and novelists. He also provides expert testimony and consultations for defense attorneys across America. Email Evan Your Comments and Questions  talkback@gun.lawyer Join Evan's InnerCircleHere's your chance to join an elite group of the Savviest gun and knife owners in America.  Membership is totally FREE and Strictly CONFIDENTIAL.  Just enter your email to start receiving insider news, tips, and other valuable membership benefits.   Email (required) *First Name *Select list(s) to subscribe toInnerCircle Membership Yes, I would like to receive emails from Gun Lawyer Podcast. (You can unsubscribe anytime)Constant Contact Use. Please leave this field blank.var ajaxurl = "https://gun.lawyer/wp-admin/admin-ajax.php";

Nicola Longo MD, PhD, and Mark Roberts, MD Nicola Longo MD, PhDProfessor and Vice Chair of Human Genetics,Allen and Charlotte Ginsburg Chair in Precision Genomic Medicine,Division of Clinical Genetics, Department of Human Genetics,University of California at Los Angeles (UCLA), Los Angeles, CA, USAMark Roberts, MDProfesor and Consultant Neurologist,University of Manchester, Manchester, UKResearch Lead for Adult Metabolic Medicine at Salford Care Organisation, Manchester, UKDrs. Longo and Roberts discuss the current status of gene therapies in rare neuromuscular disorders in this eight-part podcast series. This is derived from the symposium that was presented at World Symposium 2025 in San Diego, California on February 4th through 7th, 2025 and is intended for healthcare professionals only. This podcast includes information about investigational compounds that do not yet have a regulatory approval or authorization for a specific indication. The safety and efficacy of the agents under investigation have not been established and contents of this podcast shall not be used in any manner to directly or indirectly promote or sell the product for unapproved uses. The views, thoughts, and opinions expressed in this presentation belong solely to the author and are subject to change without notice.The contents of this presentation do not constitute an endorsement of any product or indication by Astellas. In this part, Dr. Roberts will discuss vectors, different strategies, modes of administration and targets in gene replacement therapies.Mark Roberts, MDNow in the broader sense, gene replacement therapy seeks to actually deliver genetic material directly into the host cell to influence gene expression. In the most simple idea, one of course has a vector, this is most commonly but not exclusively a virus, which can then be given intravenously for example, and can hope to potentially correct the condition within the individual cells using novel transgenes. Suitable candidate conditions for this as examples of genetic conditions are now well understood. And crucially, this applies not only towards some more recessive, but dominant and even accident conditions.Across the piece, one can see for example, mitochondrial problems, spinal muscular atrophy as is well known, X-linked myotubular myopathy, Duchenne muscular dystrophy, a very common condition affecting one in 3000 male individuals, Pompe disease of course, an important focus of the meeting here, but other very common conditions, for example, cystic fibrosis, immunological conditions and perhaps obviously very crucial in early work on gene therapy, hemophilia.Let's now think about the approaches to gene therapy. One can seek to work at the DNA level and gene replacement. In essence, one is trying to put a new transgene through into the nucleus that will ultimately be transcribed and translated and produce the important functional protein that is lost. Gene editing which is a very exciting new technology or CRISPR technology actually seeks to actually modify in vivo the actual mutations that are responsible for the pathogenic production of abnormal proteins and correcting these and actually producing a more normalized protein.But of course there are also RNA approaches where one seeks to actually repair the mRNA transcripts copied from the mutated gene. For example, this may be a novel approach that could be extremely useful in myotonic dystrophy, a multisystem condition. When we talk about the viral vectors, predominantly we're talking about viruses. Those such as adenoviruses and AAV viruses which have the virtue of not integrating into the host genome or at least not in a large amount, and those which deliberately seek to integrate into host genome such as retroviral or lentiviral systems that may be particularly useful for ex vivo systems.There are of course other ways to get genetic payloads into the nucleus, various polymers, nanoparticles and even cell penetrating peptides. Nanoparticles in particular is certainly on the ascendant. That being said, in a recent review of the clinical trials in gene therapy, it was certainly the viral vectors that stood out both in direct gene replacement with lentivirus and AAV, but also actually as delivery systems, for example, for gene editing. An example of what one is seeking to do with AAV, so of course one seeking to remove the native DNA, insert the new transgene directly into the vector and of course keen to make sure that there's a high transmission into the capsid producing a recombinant AAV, which then can be given as a treatment and hopefully produce a therapeutic increase in the functional protein that is deficit in the disorder.In the next part, Dr. Roberts will discuss immune responses and other safety concerns related to gene therapies.

From Naval Academy to Acting Secretary: Colleague Thomas Modly discusses his memoir Vectors, detailing his journey from the Naval Academy class of 1983 to becoming an aviator and Pentagon official, reflecting on his family's immigrant history, working under Donald Rumsfeld on defense reform, and accepting the role of Under Secretary of the Navy. 1888

Amb. Jimmy Story provides a real-time perspective on prospects for democracy in Venezuela and the Western Hemisphere

Daily audio recordings of CMFI Praise, Prayer and Fasting Crusade. From 13th October to 21st Nov 2025

Editor-in-Chief of Molecular Therapy, Dr. Joseph Glorioso, is joined by Rachael Nimmo, PhD, former director of the Cell Technology Group at Oxford Biomedica, and Kyriacos Mitrophanous, PhD, Chief Innovation Officer at Oxford Biomedica, to discuss an article recently published in Molecular Therapy by Nimmo and colleagues titled “Efficient in vivo generation of CAR T cells using a retargeted fourth-generation lentiviral vector.” Music: 'Electric Dreams' by Scott Buckley - released under CC-BY 4.0. www.scottbuckley.com.auShow your support for ASGCT!: https://asgct.org/membership/donateSee omnystudio.com/listener for privacy information.

LLMs generate text painfully slow, one low-info token at a time. Researchers just figured out how to compress 4 tokens into smart vectors & cut costs by 44%—with full code & proofs! Meanwhile OpenAI drops product ads, not papers. We explore CALM & why open science matters.

November 10, 2025 ~ Frank Weisser, U.S. Navy Commander and author of “LEAD SOLO: Learning Life's Vectors from an F/A-18 Blue Angel Aviator,” joins Kevin ahead of Veterans Day. Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

We kicked off the program with four news stories and different guests on the stories we think you need to know about!N.H. investigators asking witnesses to 1989 disappearance to come forwardGuest: Emily Sweeney – Boston Globe Cold Case Files reporter From the cockpit of an F/A-18 Hornet, Cdr. Frank Weisser, USN, conveys the lessons he learned flying as the Lead Solo for the Blue Angels, on multiple combat deployments, and as stunt pilot for the blockbuster film Top Gun: Maverick. His new book: “LEAD SOLO: Learning Life’s Vectors from an F/A-18 Blue Angel Aviator” - all the net proceeds of the book going to charity.Guest: Frank Weisser - U.S. Navy Commander the Blue Angels and Combat Pilot Who Flew All the Aerial Stunts in Top Gun: Maverick & Author Stress Awareness Week - How can we stress less and live more? Addressing work stress & chronic burnout & how to tackle that.Guest: Amy Leneker - former C-suite executive and leadership advisor to Fortune 100 companies & Author, motivational speaker Remembering & Honoring Marine Lt. Alfred (Al) Lussier who gave his life saving another Marine in Alaska & died a hero.Guest: John Casey – former classmate of Al’s at BLSSee omnystudio.com/listener for privacy information.

One in four people has a disability. Why aren't we designing museums better for them?What is inclusive design? How does it relate to universal design, or the ADA? Which disciplines and departments have to get involved to make a museum truly inclusive? What happened when the military tried to design for the “average” jet pilot? If we design for better accessibility, are we designing for our own future selves?Sina Bahram and Corey Timpson (Principals, Prime Access Consulting) join host Jonathan Alger (Managing Partner, C&G Partners) to discuss “Inclusive Design Will Change the World.”Along the way: curb cuts, multimodality, and the finance department.Talking Points:1. What is Inclusive Design?2. The Average Jet Pilot3. 1 in 4 People have a Disability4. Vectors of Human Difference5. Inclusive Design Has No Boundaries6. It's a Convincing Company, not an Accessibility One7. A Company That's Hopefully Pointless One DayHow to Listen:Listen on Apple Podcasts:https://podcasts.apple.com/us/podcast/making-the-museum/id1674901311  Listen on Spotify:https://open.spotify.com/show/6oP4QJR7yxv7Rs7VqIpI1G  Listen at Making the Museum, the Website:https://www.makingthemuseum.com/podcast  Links to Every Podcast Service, via Transistor:https://makingthemuseum.transistor.fm/ Guest Bios:Sina Bahram (President, Prime Access Consulting) is a blind computer scientist, consultant, researcher, speaker, mentor, and entrepreneur. He works with executive management, policymakers, engineering teams, content creators, designers, and others to promulgate accessibility and inclusive design throughout an organization. In 2012, President Obama recognized Sina as a White House Champion of Change. Sina and his PAC colleagues collaborate on creating digital experiences (web, app, embedded, projected, and more), immersive media, themed entertainment, capital builds, and any/all aspects of experiential design in order to welcome the widest possible audience. Sina serves on and chairs various corporate, research, and non-profit boards. Sina is a Mission Astro Access ambassador and recipient of a Thea Award.Corey Timpson (Principal, Prime Access Consulting) is an active collaborator and thought leader in the fields of inclusive design, digital media, and experience design within the cultural and themed entertainment industries. As one of the two principals of Prime Access Consulting, Inc. (PAC) Corey's primary focus is to facilitate the creation of inclusive, rich, and meaningful experiences that are welcoming to everyone. Among Corey's previous positions, he was the Vice-President of Exhibitions, Research, and Design, and concurrently served as the Project Director, for the design-build of the Canadian Museum for Human Rights where his focus was on interpreting difficult knowledge and presenting it through an inclusive, multimodal, and transmedia storytelling approach. Corey's design leadership has accounted for over 30 international awards in the fields of environmental, exhibition, and graphic design, digital and interactive media, digital systems design, film and linear media, and universal design. Corey serves as an Advisory Board member of Europe's Best in Heritage and is a board member of the Portrait Gallery of Canada.About Making the Museum:Making the Museum is hosted (podcast) and written (newsletter) by Jonathan Alger. MtM is a project of C&G Partners | The Exhibition and Experience Design Studio.Learn more about the creative work of C&G Partners:https://www.cgpartnersllc.com/ Links for This Episode:Prime Access Consulting (PAC):https://pac.bz Mosaic (M4C):https://m4c.space Links for Making the Museum, the Podcast:Contact Making the Museum:https://www.makingthemuseum.com/contact Host Jonathan Alger, Managing Partner of C&G Partners, on LinkedIn:https://www.linkedin.com/in/jonathanalger Email Jonathan Alger:alger@cgpartnersllc.com C&G Partners | The Exhibition and Experience Design Studio:https://www.cgpartnersllc.com/ Making the Museum, the Newsletter:Like the show? You might enjoy the newsletter. Making the Museum is also a free weekly professional development email for exhibition practitioners, museum leaders, and visitor experience professionals. (And newsletter subscribers are the first to hear about new episodes of this podcast.)Join hundreds of your peers with a one-minute read, three times a week. Invest in your career with a diverse, regular feed of planning and design insights, practical tips, and tested strategies — including thought-provoking approaches to technology, experience design, audience, budgeting, content, and project management.Subscribe to the newsletter:https://www.makingthemuseum.com/

Newt talks with former Acting Secretary of the Navy, Thomas Modly about his book, “Vectors: Heroes, Villains, and Heartbreak on the Bridge of the U.S. Navy.” Modly discusses his tenure as Acting Secretary and insights into the challenges facing the U.S. Navy. The son of Eastern European immigrants, he shares how his parents' experiences helped shape his views on America and his decision to serve in the U.S. Navy. He reflects on the transformation of Hungary post-Iron Curtain and the importance of a strong U.S. military. Modly highlights the need for a national maritime strategy and addresses the Navy's current challenges, including shipbuilding and financial audits. He emphasizes the importance of effective leadership, communication, and agility in military operations. Modly also offers advice to Naval Academy graduates, urging them to focus on their commitment to the Constitution and the people they lead.See omnystudio.com/listener for privacy information.

What if solving tomorrow's bioprocessing challenges meant questioning the very physics of chromatography and reimagining downstream processing from the ground up?For years, large biomolecules like viral vectors and exosomes have squeezed through the limitations of traditional chromatography, leaving scientists to wrestle with capacity trade-offs and slow mass transfer. But what if a fundamental shift could unlock breakthroughs for gene therapies, vaccines, and advanced biologics?In this thought-provoking episode, host David Brühlmann sits down with Alois Jungbauer, professor emeritus of downstream processing at BOKU University (Vienna) and scientific advisor at BioChromatographix International. Together, they examine the future of chromatography and downstream processing, exploring innovations that tackle the challenges of modern gene therapy, advanced therapeutics, and sustainability in manufacturing.Alois shares his perspective on anticipating industry needs, the importance of mentorship, and why the physical limits for purification of large biomolecules are yet to be reached.Episode Highlights:The difference between solving current problems and anticipating the needs of the next generation in biotech (00:00)The promise and technical details of monolithic chromatography and its application for large modalities like gene therapy vectors and exosomes (03:01)Explanation of “inverted morphology" and AXISFLOW™ in new chromatography materials (03:18)Challenges and opportunities in continuous gene therapy vector production, and why it's not widespread yet (07:40)The critical role of sustainability in downstream processing, particularly water usage and its impact on the viability and costs of distributed manufacturing (10:30)The relationship between reducing water consumption, manufacturing footprint, and cost of goods (12:16)Advice on scientific career development: listening, reading, understanding future industry needs, finding a mentor, and having persistence (13:50)Broader reflections on the value of science, societal perceptions, and science communication in today's world (17:34)Alois's key takeaway: downstream processing for gene therapy has not yet reached its physical limits—there is still significant room for improvement (20:26)If you're looking for fresh strategies to tackle the bottlenecks of large-molecule purification - and a candid perspective on where the real opportunities and societal responsibilities lie - you won't want to miss this conversation.Connect with Alois Jungbauer at leading conferences, including Bioprocessing Summit and Bioprocessing International, or find the next integrated continuous biomanufacturing event where he's co-chairing.Connect with Alois Jungbauer:LinkedIn: www.linkedin.com/in/alois-jungbauer-14984811Website : www.biochromatographix.comNext step:Book a 20-minute call to help you get started on any questions you may have about bioprocessing analytics: https://bruehlmann-consulting.com/callPreparing for your IND? We're building a CMC Dashboard in Excel to help biotech founders track tasks, timelines, and risks in one place. Join the waitlist for early access at

The CFIA ordered a full ostrich cull after H5N1 was detected, even though wild migratory birds likely contaminated the farm's pond — making the ostriches victims, not disease spreaders New studies from California dairy farms show H5N1 in air and wastewater, suggesting industrial livestock operations are aerosolizing and recycling the virus back into the environment through waste systems Despite evidence of natural immunity, CFIA's policy mandates culling all birds on an exposed site, ignoring science and logic by killing healthy survivors that pose less risk Factory farms generate billions of pounds of untreated manure annually, with open-air lagoons and runoff creating ideal conditions for virus transmission — yet regulatory focus remains on small farms A smarter policy would target the real sources — contaminated air, lagoons, and waste — not small farms. Testing, environmental controls, and accountability must come before destroying healthy animals

In this episode, host David Brühlmann is joined by Alois Jungbauer, Professor Emeritus at BOKU University, Vienna, and Scientific Advisor at BioChromatographix International. With over 40 years in bioprocess engineering and more than 400 published papers, Jungbauer offers a unique perspective on how downstream processing and purification technologies have evolved and where they're headed next.Alois shares his unconventional journey into the world of biotech, starting from humble beginnings on an Austrian farm, and discusses key turning points that have shaped the industry. Together, they explore the latest challenges triggered by high cell culture titers, new therapeutic modalities, and the drive for automation and process integration in manufacturing.In this episode:Why the gap between upstream and downstream processes remains a core bottleneck (03:27)How rigid and convective chromatography materials changed throughput and efficiency (06:56)The shift in purification strategies with skyrocketing titers in cell culture (08:43)Automation and integrated biomanufacturing: their role in making processes more robust and continuous (10:20)Misconceptions around resin costs in full-scale versus clinical-scale manufacturing (12:10)What automation and process monitoring mean for real-time release and factory scheduling (14:05)The resurgence and application of displacement chromatography for gene therapy vectors (15:49)Whether you're deep into process development or just curious about the next wave in biotech manufacturing, Alois Jungbauer's insights offer valuable context for the road ahead.Connect with Alois Jungbauer:LinkedIn: www.linkedin.com/in/alois-jungbauer-14984811Website : www.biochromatographix.comNext step:Book a 20-minute call to help you get started on any questions you may have about bioprocessing analytics: https://bruehlmann-consulting.com/callPreparing for your IND? We're building a CMC Dashboard in Excel to help biotech founders track tasks, timelines, and risks in one place. Join the waitlist for early access at https://scale-your-impact.notion.site/27dd9c6ba679804b80a7ce439d56c91a?pvs=105

Is this political? It's certainly ideological against the church. If you want to know the motivation, a lot of times, is as easy as seeing who the target of the shooting is. Paul Mauro is a Fox News Contributor and former NYPD Inspector.

In this episode of the Shift AI Podcast, Dr. Vanja Josifovski, CEO of Kumo and former CTO of Airbnb and Pinterest, joins host Boaz Ashkenazy to explore how artificial intelligence is transforming the way businesses unlock value from their structured data. Josifovski shares his journey from building recommendation systems for millions of users to founding Sequoia-backed Kumo, which is tackling one of AI's biggest challenges: turning business data into actionable insights.From his early days witnessing the evolution of embeddings and vector representations to today's transformer revolution, Josifovski offers a unique perspective on the AI landscape. The conversation delves into why the current AI boom has largely overlooked structured business data, the future of personalized consumer experiences, and how coding tools are democratizing software development. If you're interested in understanding how enterprise data can drive better business decisions and what the future holds for work in an AI-driven world, this episode offers invaluable insights from someone who's been at the forefront of the AI revolution for two decades.Chapters:[02:00] Vanja's Background and AI Journey [04:00] The Evolution of Embeddings and Vectors [07:00] Silicon Valley's AI Revolution [09:00] Founding Kumo and the Enterprise Data Problem [12:00] The Future of Personalization [15:00] How AI is Changing Software Development [18:00] The Optimistic Future of Work [21:00] Societal Changes and Abundance [25:00] From Big Tech to Startup Life [00:28:00] Two Words for the Future: "Lots of Fun"Contact Info:Connect with Vanja Josifovski:● Website: kumo.aiConnect with Boaz Ashkenazy:● LinkedIn: https://www.linkedin.com/in/boazashkenazy● Email: info@shiftai.fm

Today's guest knows what it means to lead when the stakes are high. Nate Amidon spent 15 years guiding people and programs across the U.S. Air Force, Microsoft, Boeing, and Alaska Airlines. He's an Air Force C-17 evaluator pilot with more than 3,200 flight hours—including 800 in combat—and over 1,500 hours as an instructor teaching young pilots how to fly, make decisions under pressure, and lead crews on global missions. When he transitioned from active duty, Nate brought that same discipline into technology—consulting as a Project Manager, Scrum Master, and Scaled Agile Framework coach on enterprise software programs. He went on to found Form100 Consulting, where he helps clients apply military-tested leadership practices to build strong, high-performing teams that endure. In our conversation, Nate and I talked about how hard that transition actually was. Even with a degree from the Air Force Academy and an MBA, landing his first role at Microsoft wasn't simple—and it showed him how untapped the veteran talent pool really is. That frustration was the spark for Form100, where he now connects veterans with organizations desperate for alignment, communication, and trust. We also dug into why veterans are uniquely equipped for tech: they're trained to see the whole mission, not just their own slice. They know how to drive clarity in chaos, how to align teams across silos, and how to solve problems with urgency but also with care. Nate reminded us that in technology, speed without alignment is just drift. Veterans bring the perspective to check the vector, build relationships, and keep the team moving in the right direction. Nate holds a Management degree from the U.S. Air Force Academy, an MBA from the University of Nebraska, and certifications spanning PMP, CSM, SPC, Lean Six Sigma, and DevOps. He also continues to serve as a reservist C-17 pilot with the 313th Airlift Squadron.

In this episode of CISO Tradecraft, host G Mark Hardy engages in an insightful conversation with Dave Lewis, Global Advisory CISO from 1Password, about AI governance and its importance in cybersecurity. They discuss AI policy and its implications, the evolving nature of AI and cybersecurity, and the critical need for governance frameworks to manage AI safely and securely. The discussion delves into the visibility challenges, shadow AI, the role of credentials, and the importance of maintaining fundamental security practices amidst rapid technological advancements. They also touch on the potential risks associated with AI, the misconceptions about its impact on jobs, and the need for a balanced approach to leveraging AI in a beneficial manner while safeguarding against its threats. This episode provides valuable guidance for cybersecurity professionals and organizations navigating the complexities of AI governance. Chapters 00:00 Introduction to AI Governance 00:30 Guest Introduction: Dave Lewis 00:49 The Importance of AI Governance 01:42 Challenges in AI Implementation 03:20 AI in the Modern Enterprise 03:49 Shadow AI and Security Concerns 04:49 AI's Impact on Jobs and Industry 05:27 The Gartner Hype Cycle and AI 05:43 AI's Influence on the Stock Market 06:14 Historical Context of AI 06:32 AI and Credential Security 08:29 The Role of Governance in AI 12:47 The Future of AI and Security 18:36 Governance and Policy Recommendations 19:26 AI Governance and Ethical Concerns 20:01 AI Self-Preservation and Human Safety 20:18 Uncontrollable AI Applications 21:17 Vectors of AI Trouble 21:58 AI Hallucinations and Data Security 22:53 AI Vulnerabilities and Exploits 26:29 Deepfakes and AI Misuse 27:33 Historical Cybersecurity Incidents 29:04 Future of AI and Job Security 33:47 Managing AI Identities and Credentials 34:21 Conclusion and Final Thoughts

In this episode of CISO Tradecraft, host G Mark Hardy engages in an insightful conversation with Dave Lewis, Global Advisory CISO from 1Password, about AI governance and its importance in cybersecurity. They discuss AI policy and its implications, the evolving nature of AI and cybersecurity, and the critical need for governance frameworks to manage AI safely and securely. The discussion delves into the visibility challenges, shadow AI, the role of credentials, and the importance of maintaining fundamental security practices amidst rapid technological advancements. They also touch on the potential risks associated with AI, the misconceptions about its impact on jobs, and the need for a balanced approach to leveraging AI in a beneficial manner while safeguarding against its threats. This episode provides valuable guidance for cybersecurity professionals and organizations navigating the complexities of AI governance. Chapters 00:00 Introduction to AI Governance 00:30 Guest Introduction: Dave Lewis 00:49 The Importance of AI Governance 01:42 Challenges in AI Implementation 03:20 AI in the Modern Enterprise 03:49 Shadow AI and Security Concerns 04:49 AI's Impact on Jobs and Industry 05:27 The Gartner Hype Cycle and AI 05:43 AI's Influence on the Stock Market 06:14 Historical Context of AI 06:32 AI and Credential Security 08:29 The Role of Governance in AI 12:47 The Future of AI and Security 18:36 Governance and Policy Recommendations 19:26 AI Governance and Ethical Concerns 20:01 AI Self-Preservation and Human Safety 20:18 Uncontrollable AI Applications 21:17 Vectors of AI Trouble 21:58 AI Hallucinations and Data Security 22:53 AI Vulnerabilities and Exploits 26:29 Deepfakes and AI Misuse 27:33 Historical Cybersecurity Incidents 29:04 Future of AI and Job Security 33:47 Managing AI Identities and Credentials 34:21 Conclusion and Final Thoughts

Fill out this short listener survey to help us improve the show: https://forms.gle/bbcRiPTRwKoG2tJx8In this episode, Simon Eskildsen, co-founder and CEO of TurboPuffer, lays out a compelling vision for how AI-native infrastructure needs to evolve in an era where every application wants to connect massive amounts of context to large language models. He breaks down why traditional databases and even large context windows fall short—especially at scale—and why object-storage-native search is the inevitable next step. Drawing on his experience from Shopify and Readwise, Simon introduces the SCRAP framework to explain the limits of context stuffing and makes a clear case for why cost, recall, performance, and access control drive the need for smarter retrieval systems. From practical lessons in building highly reliable infra to hard technical problems in vector indexing, this conversation distills the future of AI infra into first principles—with clarity and depth. [0:00] Intro[0:49] The Evolution of AI Context Windows[2:32] Challenges in AI Data Integration[3:56] SCRAP: Scale, Cost, Recall, ACLs, and Performance[9:21] The Rise of Object-Oriented Storage[16:47] Turbo Puffer Use Cases[22:32] Challenges in Vector Search[27:02] Challenges in Query Planning and Data Filtering[27:53] Focusing on Core Problems and Simplicity[28:28] Customer Feedback and Future Directions[29:11] Reliability and Simplicity in Design[30:39] Evaluating Embedding Models and Search Performance[32:17] The Role of Vectors in Search Engines[34:16] Balancing Focus and Expansion[35:57] AI Infrastructure and Market Trends[38:36] The Future of Memory in AI[43:01] Table Stakes for AI in SaaS Applications[45:55] Multimodal Data and Market Observations[46:57] Quickfire With your co-hosts: @jacobeffron - Partner at Redpoint, Former PM Flatiron Health @patrickachase - Partner at Redpoint, Former ML Engineer LinkedIn @ericabrescia - Former COO Github, Founder Bitnami (acq'd by VMWare) @jordan_segall - Partner at Redpoint

Ben STILL has too many review codes, so Aunt Norah is back to help him get through the backlog. Norah watches the trailer, Ben plays the game, and they discuss their impressions. This episode contains three conversations themed around the games Ben has been playing for review purposes. Topics and games covered this week include the following: the impact of vector graphics featuring Stratogun, the nostalgia of GBA-style adventure games with Pipistrello and the Cursed Yoyo, and exploring the dating sim concept in Date Everything! *** PART 1 - Vector graphics in the game Stratogun Horsefly Games' Stratogun trailer - https://www.youtube.com/watch?v=qdO3LJmYVqc 00:00:20 - Norah's maths, Asteroids on sphere, and the difference between vectors and pixels 00:03:26 - Ben wanted a Vectrex, Norah's thoughts on the trailer, and game mechanics in brief 00:08:13 - Too frantic for Norah, thoughts on an unnecessary mechanic, and the endorphins 00:10:24 - The first vector graphics game designed by a woman, and problems with signing  00:12:24 - Atari's reimagined classics, Ben's gets even more nostalgic, and vector pinball? PART 2 - The joy of handheld game systems and yo-yos in Pipistrello and the Cursed Yoyo Pocket Trap's Pipistrello and the Cursed Yoyo trailer - https://www.youtube.com/watch?v=fRd-fEJFeuk 00:15:14 - Pipi Longstocking, pronouncing cursed, Super DodgeBall arcade, and pastrami  00:17:28 - The power of roses, your mission, and Norah appreciates the aunt-heavy narrative  00:19:05 - The other aunt, Norah's question about the retro game aesthetic, and game difficulty  00:23:35 - Norah's question about the story, from a certain point of view, and money motives? 00:25:56 - Console availability, special editions, difficulty options, and badges and contracts 00:30:17 - Using a REAL yo-yo, the old timey name, being fancily dressed, and a trivia nugget PART 3 - Thoughts on traditional dating simulators and the game Date Everything! Sassy Chap Games' Date Everything! - https://www.youtube.com/watch?v=v2Rv9zX3K24 00:32:24 - Dating objects in your home, trailer assessment, and not for general audiences 00:35:02 - Dating a joke gift, three relationship labels, pods and pins, and your end goal 00:37:47 - In-game “warnings,” questions, in the kitchen, NO SPORK, and some weirder ones 00:42:07 - Over 100 credited voice actors… https://www.imdb.com/title/tt33039855/fullcredits/ 00:43:55 - Daily conversations, the sandbox descriptor, and some bugs that Ben encountered 00:49:34 - “80s movie” summaries, Ben's final verdict, and an encyclopedia sized experience 00:52:42 - Ticking the weird box, it needs more balance, and working around the monotony  00:55:13 - Another bug, a dating fail, the evolution of dating sims, and making fun of the genre *** Follow Two Vague on… Our website: https://www.twovaguepodcast.com On Instagram: https://www.instagram.com/two_vague_podcast On YouTube: https://www.youtube.com/@twovaguepodcast On Substack: https://twovaguepodcast.substack.com/ On Bluesky: https://bsky.app/profile/twovaguepodcast.com For show appearance and other inquiries, contact us at: twovaguepodcast@gmail.com -AND-  …for all of your PRI and 2VP merch check out the Partly Robot Industries store at TEEPUBLIC! https://www.teepublic.com/user/partly-robot-industries *** References, Links, and Tags For more information on Stratogun… https://horsefly.games/ https://numskullgames.com/ https://store.steampowered.com/app/3088430/Stratogun/ For more information on Pipistrello and the Cursed Yoyo…  https://pocket-trap.com/ https://www.pm-studios.com/ https://store.steampowered.com/app/2870350/Pipistrello_and_the_Cursed_Yoyo/ For more information on Date Everything!… https://dateeverything.com/ https://www.team17.com/ https://store.steampowered.com/app/2201320/Date_Everything/ #Podbean #DIYPodcast #ApplePodcast #VideoGames #Trivia #Comedy #Talkshow #2VP #TwoVaguePodcast #PodernFamily #InterviewShow #GamersofThreads #Gamer #PartlyRobot #PartlyRobotIndustries #TeePublic #DateEverything #SassyChapGames #Team17  #PipistrelloandtheCursedYoyo #PocketTrap #PMStudios #Stratogun #HorseflyGames #NumskullGames

سلام عليكم الخوت و الخوات! مرحبا بكم ف هاد الحلقة الجديدة ديالنا.ف هاد الوقت اللي الـ AI و الـ LLM's (بحال ChatGPT) ولاو جزء من حياتنا، كاين واحد السؤال كبييير: كيفاش نخبعوا هاد الداتا كاملة، بالطريقة اللي تكون رخيصة و سريعة ف نفس الوقت؟ و هنا فين كايجي AWS S3 Vectors!ف هاد الحلقة، غادي ندويو على هاد الـ feature الجديدة من Amazon S3، اللي غادي تغيّر بزاف الإستعمال ديال "Vector Embeddings"

PF Jung is an enlightened centrist! Meaning, disagrees with everyone! How, exactly, is the subject of this calmvo.https://www.youtube.com/@PFJung https://x.com/PF_JungSupport this channel:https://www.paypal.me/benjaminboycehttps://cash.app/$benjaminaboycehttps://www.buymeacoffee.com/benjaminaboyce

TE US NAVY IS THE SECURITY O F THE EMPIRE.  1/4: Vectors: Heroes, Villains, and Heartbreak on the Bridge of the U.S. Navy by  Thomas B. Modly  (Author) https://www.amazon.com/Vectors-Heroes-Villains-Heartbreak-Bridge/dp/1642257036 Thomas Modly had an eclectic career in the military, academia, business, and government when he answered the call to service in 2017 and returned to the Navy where his career began. His experience, as chronicled in these pages, tells the story of Secretary Modly's quest to advance the Department of the Navy's preparedness for the challenges of this century. As Acting Secretary of the Navy he held fast to the mantra of “acting, not pretending,” and thus advocated aggressively for the Navy and Marine Corps' future ― a future he believed would be defined by uncertainty and unpredictability. Every Friday he wrote a personal message to the entire Department regardless of rank. Those messages were called SECNAV Vectors. Each Vector was intended to clearly communicate his priorities and to establish a rapport with all levels of the organization. The subject of each Vector was inspired by real events that occurred in real time. As these events unfolded , the Secretary's unyielding emphasis on being prepared for unpredictable events are proven to be prescient as the Navy found itself, unintentionally, in the center of COVID-19 crisis. JAMUARY 1, 1905 RECEPTION AT THE WHITE HOUSE. LED BY ADMIRAL DEWEY.

TE US NAVY IS THE SECURITY O F THE EMPIRE.  2/4: Vectors: Heroes, Villains, and Heartbreak on the Bridge of the U.S. Navy by  Thomas B. Modly  (Author) https://www.amazon.com/Vectors-Heroes-Villains-Heartbreak-Bridge/dp/1642257036 Thomas Modly had an eclectic career in the military, academia, business, and government when he answered the call to service in 2017 and returned to the Navy where his career began. His experience, as chronicled in these pages, tells the story of Secretary Modly's quest to advance the Department of the Navy's preparedness for the challenges of this century. As Acting Secretary of the Navy he held fast to the mantra of “acting, not pretending,” and thus advocated aggressively for the Navy and Marine Corps' future ― a future he believed would be defined by uncertainty and unpredictability. Every Friday he wrote a personal message to the entire Department regardless of rank. Those messages were called SECNAV Vectors. Each Vector was intended to clearly communicate his priorities and to establish a rapport with all levels of the organization. The subject of each Vector was inspired by real events that occurred in real time. As these events unfolded , the Secretary's unyielding emphasis on being prepared for unpredictable events are proven to be prescient as the Navy found itself, unintentionally, in the center of COVID-19 crisis. 1905 RUSSIA ADMIRAL KORNILOV

TE US NAVY IS THE SECURITY O F THE EMPIRE.  3/4: Vectors: Heroes, Villains, and Heartbreak on the Bridge of the U.S. Navy by  Thomas B. Modly  (Author) https://www.amazon.com/Vectors-Heroes-Villains-Heartbreak-Bridge/dp/1642257036 Thomas Modly had an eclectic career in the military, academia, business, and government when he answered the call to service in 2017 and returned to the Navy where his career began. His experience, as chronicled in these pages, tells the story of Secretary Modly's quest to advance the Department of the Navy's preparedness for the challenges of this century. As Acting Secretary of the Navy he held fast to the mantra of “acting, not pretending,” and thus advocated aggressively for the Navy and Marine Corps' future ― a future he believed would be defined by uncertainty and unpredictability. Every Friday he wrote a personal message to the entire Department regardless of rank. Those messages were called SECNAV Vectors. Each Vector was intended to clearly communicate his priorities and to establish a rapport with all levels of the organization. The subject of each Vector was inspired by real events that occurred in real time. As these events unfolded , the Secretary's unyielding emphasis on being prepared for unpredictable events are proven to be prescient as the Navy found itself, unintentionally, in the center of COVID-19 crisis. 1905 RUSSO-JAPANESE WAR

TE US NAVY IS THE SECURITY O F THE EMPIRE.  4/4: Vectors: Heroes, Villains, and Heartbreak on the Bridge of the U.S. Navy by  Thomas B. Modly  (Author) https://www.amazon.com/Vectors-Heroes-Villains-Heartbreak-Bridge/dp/1642257036 Thomas Modly had an eclectic career in the military, academia, business, and government when he answered the call to service in 2017 and returned to the Navy where his career began. His experience, as chronicled in these pages, tells the story of Secretary Modly's quest to advance the Department of the Navy's preparedness for the challenges of this century. As Acting Secretary of the Navy he held fast to the mantra of “acting, not pretending,” and thus advocated aggressively for the Navy and Marine Corps' future ― a future he believed would be defined by uncertainty and unpredictability. Every Friday he wrote a personal message to the entire Department regardless of rank. Those messages were called SECNAV Vectors. Each Vector was intended to clearly communicate his priorities and to establish a rapport with all levels of the organization. The subject of each Vector was inspired by real events that occurred in real time. As these events unfolded , the Secretary's unyielding emphasis on being prepared for unpredictable events are proven to be prescient as the Navy found itself, unintentionally, in the center of COVID-19 crisi. 1912 BATTLESHIP WYOMING.

In this episode, Dave interviews Jack Pertschuk, principal engineer for Algorithms and Platform at Pinecone. They discuss:What semantic search is and where it falls shortThe difference between sparse and dense vectorsHow search technology powers AI

Deciding where to "place" an instrument is one of the biggest decisions of a mixing engineer. Simply putting a guitar in the left, right, or center can completely change the vibe of a song.But there are more ways to trick the brain than on! Let's explore delay-based, phase-based, and timbre-based panning options, and how their nuances can change the way the music hits!For 30% off your first year with DistroKid to share your music with the world click ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠DistroKid.com/vip/lovemusicmore⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Want to hear my music? For all things links visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ScoobertDoobert.pizza⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Subscribe to this pod's blog on ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Substack⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to receive deeper dives on the regular

Max talks about common gotchas with RNAV GPS approaches, especially when using vectors to final (VTF). The conversation picks up where Episode 383 left off, with listeners asking how vectors to final (VTF) influences glidepath capture on WAAS approaches. He explains that under normal circumstances—flying the approach via own navigation from an initial approach fix (IAF)—the GPS glidepath doesn't turn magenta or allow autopilot coupling until the FAF becomes the active waypoint. The magenta color indicates that the GPS receiver has completed a signal quality evaluation, verifying that the WAAS signal is good enough for LPV minimums. Until this point, the glidepath indicator remains a hollow white diamond, and the autopilot will not descend. However, activating VTF triggers this signal check immediately, regardless of the aircraft's location. If the aircraft's track is within approximately 100–110° of the final approach course, the glidepath indicator turns magenta and autopilot coupling becomes possible—even miles from the airport. This can be risky if the aircraft is outside the protected segment of the published procedure, especially in mountainous terrain where blindly following the glidepath can be hazardous. Max notes that activating VTF early, particularly from a downwind leg, may display the “SUSP” annunciator. He urges pilots not to press the SUSP button in this scenario, as it can inadvertently sequence legs inappropriately or disable the approach altogether. The SUSP annunciator will clear automatically during the final base-to-final turn, provided it's within 45° of the final approach course. The episode then shifts to a common gotcha with ILS and RNAV approaches when being vectored in close. If a controller brings an aircraft in at an altitude that puts it above the glidepath—and the vertical deviation indicator centers before the lateral CDI centers—the autopilot will capture lateral guidance but not vertical guidance. Max describes this firsthand from a recent Vision Jet flight into Orange County, where his awareness helped avoid a missed capture. If the autopilot fails to capture the glidepath due to this timing issue, pilots must use vertical speed (VS) mode to manually descend and re-intercept it. Responding to listener Matt's question, Max discusses the use of VNAV (Vertical Navigation) mode as another way to descend to the glidepath for early coupling. He clarifies that while VNAV is a separate topic, it's related because it can assist with managing step-down altitudes more precisely. If VNAV is properly configured—usually in conjunction with the APPR key—it can manage the descent and transition into the glidepath at the FAF. However, Max warns of several pitfalls: pilots often forget to dial in a lower altitude, which prevents descent; older G1000 systems may ignore VNAV commands if the top of descent (TOD) is more than five minutes away; and using VNAV may not align with ATC altitude restrictions. He concludes that while VNAV has become more reliable due to Garmin software improvements, it introduces complexity and requires careful verification of ATC clearances and altitude settings. If you're getting value from this show, please support the show via PayPal, Venmo, Zelle or Patreon. Support the Show by buying a Lightspeed ANR Headsets Max has been using only Lightspeed headsets for nearly 25 years! I love their tradeup program that let's you trade in an older Lightspeed headset for a newer model. Start with one of the links below, and Lightspeed will pay a referral fee to support Aviation News Talk. Lightspeed Delta Zulu Headset $1199 Lightspeed Zulu 3 Headset $899Lightspeed Sierra Headset $699 My Review on the Lightspeed Delta Zulu Send us your feedback or comments via email If you have a question you'd like answered on the show, let listeners hear you ask the question, by recording your listener question using your phone. News Stories DOT Begins Search for Lead Contractor in ATC Overhaul GAMI G100UL not universal enough to replace avgas in California Beta Makes First Electric Flight into New York's JFK Airport Spatial disorientation: GA's deadliest threat Model injured during photo shoot with Aviat pilot Pilot loses control on landing when feet get stuck on rudder North Pole man accused of flying while intoxicated Mentioned on the Show Buy Max Trescott's G3000 Book Call 800-247-6553 Lightspeed Delta Zulu Headset Giveaway Video of the Week: Canopies Open during A-26 Intruder Flight  NTSB News Talk Podcast UAV News Talk Podcast Rotary Wing Show Podcast Free Index to the first 282 episodes of Aviation New Talk So You Want To Learn to Fly or Buy a Cirrus seminars Online Version of the Seminar Coming Soon – Register for Notification Check out our recommended ADS-B receivers, and order one for yourself. Yes, we'll make a couple of dollars if you do. Get the Free Aviation News Talk app for iOS or Android. Check out Max's Online Courses: G1000 VFR, G1000 IFR, and Flying WAAS & GPS Approaches. Find them all at: https://www.pilotlearning.com/ Social Media Like Aviation News Talk podcast on Facebook Follow Max on Instagram Follow Max on Twitter Listen to all Aviation News Talk podcasts on YouTube or YouTube Premium "Go Around" song used by permission of Ken Dravis; you can buy his music at kendravis.com If you purchase a product through a link on our site, we may receive compensation.

In this episode AI and machine learning expert Pamela Fox educates Scott on how to visualize multidimensional vectors, and they talk about the complexities of explaining AI to regular people. 

Episode 386 Show Notes Topic of the show: VFR Vectors to Final. Sponsored by SGAC Patron SA On this week's show, RH and AG discuss sequencing VFR's to a Charlie airport and the etiquette involved on both sides of the mic. We also discuss a real life center controller sighting, confusing late night flying mistakes, and more of your awesome aviation feedback. Links: https://youtu.be/Dml3O6Irmt0 Timely Feedback: 1. Army IP DS answers the radar altimeter question from last week, thanks! 2. Patron SRD answers the radar altimeter question also, thank you! 3. Patron BDM asks about controllers after an incident 4. Patron JAC sends a story about his first solo cross country Feedback 1. Patron TS discusses shift work as a submariner 2. Harrier the Bean sends several interactions with ATC 3. Patron SG sends audio about audio 4. Patron DDC talks night flying for IFR training 5. Patron DB talks about a recent Center tour Have a great week and thanks for listening! Visit our website at OpposingBases.com You can support our show using Patreon or visiting our support page on the website. Keep the feedback coming, it drives the show! Don't be shy, use the "Send Audio to AG and RH" button on the website and record an audio message. Or you can send us comments or questions to feedback@opposingbases.com. Music bumpers by audionautix.com. Third party audio provided by liveatc.net. Legal Notice The views and opinions expressed on Opposing Bases Air Traffic Talk are for entertainment purposes only and do not represent the views, opinions, or official positions of the FAA, Penguin Airlines, or the United States Army. Episodes shall not be recorded or transcribed without express written consent. For official guidance on laws, rules, and regulations, consult an aviation attorney or certified flight instructor.

Episode 386 Show Notes Topic of the show: VFR Vectors to Final. Sponsored by SGAC Patron SA On this week's show, RH and AG discuss sequencing VFR's to a Charlie airport and the etiquette involved on both sides of the mic.  We also discuss a real life center controller sighting, confusing late night flying mistakes, and more of your awesome aviation feedback.  Links: https://youtu.be/Dml3O6Irmt0 Timely Feedback: 1. Army IP DS answers the radar altimeter question from last week, thanks! 2. Patron SRD answers the radar altimeter question also, thank you! 3. Patron BDM asks about controllers after an incident 4. Patron JAC sends a story about his first solo cross country Feedback 1. Patron TS discusses shift work as a submariner 2. Harrier the Bean sends several interactions with ATC 3. Patron SG sends audio about audio 4. Patron DDC talks night flying for IFR training 5. Patron DB talks about a recent Center tour Have a great week and thanks for listening!  Visit our website at OpposingBases.com You can support our show using Patreon or visiting our support page on the website.  Keep the feedback coming, it drives the show! Don't be shy, use the “Send Audio to AG and RH” button on the website and record an audio message. Or you can send us comments or questions to feedback@opposingbases.com.  Music bumpers by audionautix.com.  Third party audio provided by liveatc.net.  Legal Notice The views and opinions expressed on Opposing Bases Air Traffic Talk are for entertainment purposes only and do not represent the views, opinions, or official positions of the FAA, Penguin Airlines, or the United States Army.  Episodes shall not be recorded or transcribed without express written consent. For official guidance on laws, rules, and regulations, consult an aviation attorney or certified flight instructor.

With Microsoft Build, Google I/O, and Code with Claude all happening this week, the battle between major AI labs is heating up. This episode breaks down how to think about the AI race across five key vectors: Consumer, Enterprise, Coding, Agents, and Benchmarks. Get Ad Free AI Daily Brief: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://patreon.com/AIDailyBrief⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Brought to you by:KPMG – Go to ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://kpmg.com/ai⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to learn more about how KPMG can help you drive value with our AI solutions.Blitzy.com - Go to ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://blitzy.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to build enterprise software in days, not months Vertice Labs - Check out ⁠⁠⁠⁠⁠⁠⁠⁠http://verticelabs.io/⁠⁠⁠⁠⁠⁠⁠⁠ - the AI-native digital consulting firm specializing in product development and AI agents for small to medium-sized businesses.The Agent Readiness Audit from Superintelligent - Go to ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://besuper.ai/ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠to request your company's agent readiness score.The AI Daily Brief helps you understand the most important news and discussions in AI. Subscribe to the podcast version of The AI Daily Brief wherever you listen: https://pod.link/1680633614Subscribe to the newsletter: https://aidailybrief.beehiiv.com/Join our Discord: https://bit.ly/aibreakdownInterested in sponsoring the show? nlw@breakdown.network

In this Dialogue episode of The Synopsis, we give an update on Meta and Coupang after 1Q25 earnings. We also make some comments post Airbnb new summer announcement. Check out our written business updates for $META and $CPNG below!  Meta 1Q25 Update Coupang 1Q25 Update  Meta Company Deep Dive Podcast Episode (Apple, Spotify) Coupang Company Deep Dive Podcast Episode  (Apple, Spotify) Last Memo Published: The Invisible Competitor ~*~ For full access to all of our updates and in-depth research reports become a Speedwell Member here. Please reach out to info@speedwellresearch.com if you need help getting us to become an approved research vendor in order to expense it. -*-*-*-*-*-*-*-*-*-*-*-*-*-*- Show Notes (0:00) — Airbnb Comments post Announcement (1:53) — Meta 1Q25 Update (24:03) — Growth Vectors (29:26) — Coupang 1Q25 Update (42:37) — Forex Considerations with Investing -*-*-*-*-*-*-*-*-*-*-*-*-*-*- For full access to all of our updates and in-depth research reports, become a Speedwell Member here. Please reach out to info@speedwellresearch.com if you need help getting us to become an approved research vendor in order to expense it. *-*-*- Follow Us: Twitter: @Speedwell_LLC Threads: @speedwell_research Email us at info@speedwellresearch.com for any questions, comments, or feedback. -*-*-*-*-*-*-*-*-*-*- Disclaimer Nothing in this podcast is investment advice nor should be construed as such. Contributors to the podcast may own securities discussed. Furthermore, accounts contributors advise on may also have positions in companies discussed. At the time of publication, one or more contributors to this report has a position in CPNG and META. Furthermore, accounts one or more contributors advise on may also have a position in CPNG and META. This may change without notice. Please see our full disclaimers here:  https://speedwellresearch.com/disclaimer/

Also available on YouTube: youtu.be/m9YTxRsosJAMeta just rewrote the Facebook ads playbook—and Shopify merchants need to catch up.In this episode of The Unofficial Shopify Podcast, ad strategist Kurt Bullock (Produce Dept) breaks down how Meta's new AI-driven ad system, Andromeda, is reshaping targeting, delivery, and scale. From embeddings and vectors to Advantage+ campaigns and creative testing, this is the update your ad strategy needs.Whether you're running Facebook ads yourself or just trying to understand what your agency's talking about, this episode gives you the clarity—and tactics—to keep up.Sponsors:Zipify – Build high-converting sales funnelsCleverific – Smart order editing for ShopifyAddress Validator – Reduce delivery address errors & costsLinks & Resources:Free Resource: Creative Angle Questions + Testing FrameworkKurt Bullock: @KurtBullock on TwitterProduce Dept: https://www.producedept.coKurt Elster: https://kurtelster.comMeta Ads Manager: https://www.facebook.com/business/tools/ads-managerShopify Meta Channel: https://www.shopify.com/facebook-instagramWork with Kurt:Apply to work with Kurt: https://ethercycle.com/applyJoin the newsletter: https://kurtelster.com

Francis "Monty" Hughes hosts a conversation with Lysanne Campeau (presenter abstract #27) and Julien Ratelade (presenter abstract #33) about their research presented at ICS 2024 Madrid. Recorded at the ICS Live Lounge on Wednesday 23rd October at ICS 2024 Madrid. Through its annual meeting and journal, the International Continence Society (ICS) has been advancing multidisciplinary continence research and education worldwide since 1971. Over 3,000 Urologists, Uro-gynaecologists, Physiotherapists, Nurses and Research Scientists make up ICS, a thriving society dedicated to incontinence and pelvic floor disorders. The Society is growing every day and welcomes you to join us. If you join today, you'll enjoy substantial discounts on ICS Annual Meeting registrations and free journal submissions. Joining ICS is like being welcomed into a big family. Get to know the members and become involved in a vibrant, supportive community of healthcare professionals, dedicated to making a real difference to the lives of people with incontinence.

Jim talks with Brendan Graham Dempsey, picking up on a disagreement they had on Facebook about the teleology of the universe. They discuss Aristotle's influence on the topic, Terrence Deacon's work on naturalizing teleology, the distinction between purpose & goal-directed behavior, cosmic teleology, Teilhard de Chardin's "Omega Point," Whitehead's relational teleology, Ilya Prigogine's dissipative structures, energy efficiency comparisons between organisms & stars, the cosmic imperative of entropy production, energy rate density as a complexity measure, whether entropy is the goal or a byproduct of complexification, origin of life as contingent or necessity, Alexander Bard's emergence vectors, questioning of the heat death hypothesis, cosmic expansion possibly preventing maximum entropy, Webb telescope findings, Lee Smolin's evolutionary universe theory, philosophical implications of cosmological narratives, the deepening of interiority in cosmic evolution, Nick Chater's "The Mind Is Flat" argument, the importance of intersubjectivity, language's role in human experience, AI development & emotions, critique of transhumanism, the need to defend your emergence vector, and much more. Episode Transcript Jim's initial Facebook post JRS EP268 - Brendan Graham Dempsey on the Evolution of Meaning The Evolution of Meaning: A Universal Learning Process, by Brendan Graham Dempsey JRS EP157 - Terrence Deacon on Mind's Emergence from Matter Cosmic Evolution: The Rise of Complexity in Nature, by Eric Chaisson The Mind Is Flat, by Nick Chater "The Last Question," by Isaac Asimov Brendan Graham Dempsey is a writer, researcher, organic farmer, and the director of Sky Meadow Institute, an organization dedicated to "promoting systems-based thinking about the things that matter most." He graduated summa cum laude with a BA in religious studies and classical civilizations from the University of Vermont and earned his master's from Yale University, where he studied religion and culture. He is the author of Metamodernism: Or, The Cultural Logic of Cultural Logics and host of the Metamodern Spirituality Podcast. His primary interests include theorizing developments in culture after postmodernism, productively bridging the divide between science and spirituality, and developing sustainable systems for life to flourish. All of these lead through the paradigms of emergence and complexity, which inform all of his work.

Brenden Matthews, a seasoned software engineer, entrepreneur, and author of the Idiomatic Rust and Code Like a Pro in Rust books (both from Manning), speaks with SE Radio host Gavin Henry about Idiomatic Rust. They start with a look at what "idiomatic" means, and then discuss Generics, Traits, common design patterns you'll see in well written Rust code, and anti-patterns to avoid. Matthews suggests some tools that can help you immediately write idiomatic Rust, as well as what building blocks can also help. This episode examines what Generics are and how they compare to other languages, as well as what Traits are, how macros help, what a Fluent Interface is, and why unwrap() is bad. They also discuss what code smells to look out for, Clone, Copy, and a really nice place to go read real-world Idiomatic Rust code. Brought to you by IEEE Computer Society and IEEE Software magazine.

This week we discuss vectors in a hotter world.   Vector-borne diseases, which are transmitted by hematophagous arthropods such as mosquitoes, ticks, and sandflies, pose a significant burden on global public health. These diseases disproportionately affect populations in tropical and subtropical regions, where environmental conditions favor the survival and proliferation of vectors. Given that vectors are ectothermic organisms, their life cycles, reproduction, survival rates, and geographic distribution are heavily influenced by climate variables such as temperature, rainfall, and humidity. Consequently, changes in climate patterns can have profound effects on the transmission dynamics of vector-borne diseases, altering their geographic spread and intensity. Rising global temperatures have led to the expansion of vector habitats into previously unsuitable regions, including temperate zones. Warmer climates accelerate the development of many vectors and pathogens, reducing the extrinsic incubation period of viruses such as dengue, Zika, and chikungunya. Additionally, increased temperatures can extend the breeding season of mosquitoes like Aedes aegypti and Anopheles species, enhancing their capacity to transmit diseases such as malaria. Conversely, extreme heat events may reduce vector survival in some regions, leading to localized declines in transmission. ​Changes in precipitation patterns also play a crucial role in shaping vector distribution. Heavy rainfall events can create new breeding sites for mosquitoes by increasing the availability of stagnant water, while drought conditions may drive vectors closer to human settlements in search of water sources. In particular, shifts in rainfall patterns have been linked to outbreaks of malaria, dengue, and West Nile virus in various parts of the world. Increased humidity can further facilitate the survival of certain pathogens within vectors, enhancing their ability to transmit infections. Beyond climate variables, other anthropogenic factors contribute to the spread of vector-borne diseases. Land use changes, such as deforestation and urbanization, have disrupted natural ecosystems, bringing vectors and humans into closer contact. For example, deforestation in the Amazon has been associated with increased malaria transmission due to the creation of new breeding sites for Anopheles mosquitoes. Similarly, expanding urban populations with inadequate water management systems provide ideal conditions for the proliferation of Aedes mosquitoes, driving the rise in dengue and chikungunya cases. Globalization and human mobility further compound the issue by facilitating the movement of infected individuals and vectors across borders. Increased travel and trade have contributed to the introduction and establishment of vector-borne diseases in regions where they were previously rare. For instance, the spread of Aedes albopictus, a competent vector for dengue and chikungunya, has been linked to international trade in used tires and lucky bamboo plants, which serve as breeding grounds during transport. The multifaceted relationship between climate change and vector-borne diseases presents a challenge for public health interventions. While climate factors influence vector dynamics, their impact is often modulated by socio-economic conditions, infrastructure, and public health responses. To mitigate the growing threat of vector-borne diseases, an integrated approach is necessary—combining climate adaptation strategies, vector control measures, surveillance programs, and community engagement. Recent research underscores the importance of predictive modeling to anticipate outbreaks and inform public health policies. Advances in remote sensing, artificial intelligence, and climate modeling are enabling researchers to identify high-risk areas and implement targeted interventions. Strengthening early warning systems and investing in sustainable vector control strategies, such as genetically modified mosquitoes and Wolbachia-infected mosquito programs, offer promising avenues for reducing disease transmission. In conclusion, while climate change is reshaping the global landscape of vector-borne diseases, its effects are complex and intertwined with other environmental and societal factors. Understanding these dynamics is crucial for developing proactive strategies to mitigate the risks associated with the redistribution of vectors and the spread of diseases worldwide. By integrating climate science, epidemiology, and public health measures, we can better prepare for emerging threats and protect vulnerable populations from the growing impact of vector-borne diseases.  

MAKE HISTORY WITH US THIS SUMMER:https://demystifysci.com/demysticon-2025PATREON https://www.patreon.com/c/demystifysciPARADIGM DRIFThttps://demystifysci.com/paradigm-drift-showPATREON: get episodes early + join our weekly Patron Chat https://bit.ly/3lcAasBMERCH: Rock some DemystifySci gear : https://demystifysci.myspreadshop.com/allAMAZON: Do your shopping through this link: https://amzn.to/3YyoT98SUBSTACK: https://substack.com/@UCqV4_7i9h1_V7hY48eZZSLw@demystifysciAndrew Cutler is the author of the Vectors of Mind Substack, where he explores the question of how humans became… human. His research starts from a simple premise - if our self-awareness, the ability to look at ourselves in the mirror and declare that there is an “I” staring back, is truly unique in the animal kingdom, then it likely related to that moment of coming. But no one really knows what happened in the fog of pre-history to ratchet us from the gauzy time before we were fully human to… whatever all of this that we're living in right now could be called. In fact, this is often referred to as the sapient paradox. Why, oh why, did we become genetically modern nearly 300,000 years ago (maybe more) but take until about 50,000 years ago to start doing human things like making art, ritually burying our dead, and tracking the stars? Many have suggested it was psychedelic mushrooms that pushed us over the edge. This is the stoned ape hypothesis, which says that a sufficiently large psychedelic experience pushed us out of the womb of the earth. However, Andrew thinks it might have been something else. He figures it was snakes. And women. Together, they produced the Snake Cult of Consciousness that dragged us, kicking and screaming, into the world.(00:00) Go! (00:06:56) The Sapient Paradox Explored(00:13:09) Recursion and Human Cognition(00:19:22) Abstraction and Innovation(00:25:23) Self-awareness Evolution(00:27:14) Recursion and Strategy(00:30:00) Cultural Shifts and Domination(00:33:39) Origins of Recursion(00:38:22) Subject-Object Separation(00:47:34) Linguistic Evolution(00:48:56) Emotional Intelligence in Animals(00:50:33) Creation Myths and Self-Awareness(00:52:10) Awareness of Death in Animals(00:56:06) Evolution of Symbolic Thought(01:00:58) Göbekli Tepe and Diffusion Hypotheses(01:06:05) Matriarchy and Rituals in Early Cultures(01:08:44) Human Migration and Cultural Development(01:17:11) Origins of Human Consciousness and Language(01:25:09) Snakes, Myths, and Early Civilization(01:33:40) Women, Mythology, and Historical Narratives(01:36:30) The Subtle Female Power Dynamics in Patriarchal Societies(01:40:25) Evolution of Societal Structures(01:46:00) Neolithic Genetic Bottleneck and Patriarchal Theories(01:49:23) Women's Role in Human Cognitive Evolution(01:56:11) Symbolism of Snakes and Ancient Knowledge(02:02:10) Snake Venom Usage(02:07:12) Historical Cults and Rituals(02:11:07) Greek Tragedy and Mystery Cults(02:14:08) Matriarchy and Cultural Myths(02:17:10) Diffusion of Culture and Legends(02:22:36) Comparative Mythology and the Seven Sisters Myth(02:27:01) Scientific and Metaphysical Connections in Human Origin Stories(02:28:55) The Origins and Significance of Gospel Stories(02:30:03) Shamanistic Cults and Cultural Symbols in Ancient Sites #HumanOrigins, #AncientHistory, #Mythology, #Evolution, #Consciousness, #AncientMysteries, #Symbolism, #SelfAwareness, #HumanEvolution, #AncientCultures, #CognitiveScience, #SpiritualEvolution, #Anthropology, #Philosophy, #AncientWisdom, #Archaeology, #philosophypodcast, #sciencepodcast, #longformpodcast

 Preview: Former Acting Navy Secretary Tom Modly's "Vectors" Recounts the 2020 COVID Panic Aboard USS Theodore Roosevelt. More Later. 1936 Ranger, Lexington, Saratoga

2020 BOOTLESS PANDEMIC PANIC ON THE THEODORE ROOSEVELT.  1/4: Vectors: Heroes, Villains, and Heartbreak on the Bridge of the U.S. Navy by  Thomas B. Modly  (Author) https://www.amazon.com/Vectors-Heroes-Villains-Heartbreak-Bridge/dp/1642257036 Thomas Modly had an eclectic career in the military, academia, business, and government when he answered the call to service in 2017 and returned to the Navy where his career began. His experience, as chronicled in these pages, tells the story of Secretary Modly's quest to advance the Department of the Navy's preparedness for the challenges of this century. As Acting Secretary of the Navy he held fast to the mantra of “acting, not pretending,” and thus advocated aggressively for the Navy and Marine Corps' future ― a future he believed would be defined by uncertainty and unpredictability. Every Friday he wrote a personal message to the entire Department regardless of rank. Those messages were called SECNAV Vectors. Each Vector was intended to clearly communicate his priorities and to establish a rapport with all levels of the organization. The subject of each Vector was inspired by real events that occurred in real time. As these events unfolded , the Secretary's unyielding emphasis on being prepared for unpredictable events are proven to be prescient as the Navy found itself, unintentionally, in the center of COVID-19 crisis. 1918 Battle of the Falklands

2020 BOOTLESS PANDEMIC PANIC ON THE THEODORE ROOSEVELT.  2/4: Vectors: Heroes, Villains, and Heartbreak on the Bridge of the U.S. Navy by  Thomas B. Modly  (Author) https://www.amazon.com/Vectors-Heroes-Villains-Heartbreak-Bridge/dp/1642257036 Thomas Modly had an eclectic career in the military, academia, business, and government when he answered the call to service in 2017 and returned to the Navy where his career began. His experience, as chronicled in these pages, tells the story of Secretary Modly's quest to advance the Department of the Navy's preparedness for the challenges of this century. As Acting Secretary of the Navy he held fast to the mantra of “acting, not pretending,” and thus advocated aggressively for the Navy and Marine Corps' future ― a future he believed would be defined by uncertainty and unpredictability. Every Friday he wrote a personal message to the entire Department regardless of rank. Those messages were called SECNAV Vectors. Each Vector was intended to clearly communicate his priorities and to establish a rapport with all levels of the organization. The subject of each Vector was inspired by real events that occurred in real time. As these events unfolded , the Secretary's unyielding emphasis on being prepared for unpredictable events are proven to be prescient as the Navy found itself, unintentionally, in the center of COVID-19 crisis. 1941 Hickam Field, Pearl Harbor

2020 BOOTLESS PANDEMIC PANIC ON THE THEODORE ROOSEVELT.  3/4: Vectors: Heroes, Villains, and Heartbreak on the Bridge of the U.S. Navy by  Thomas B. Modly  (Author) https://www.amazon.com/Vectors-Heroes-Villains-Heartbreak-Bridge/dp/1642257036 Thomas Modly had an eclectic career in the military, academia, business, and government when he answered the call to service in 2017 and returned to the Navy where his career began. His experience, as chronicled in these pages, tells the story of Secretary Modly's quest to advance the Department of the Navy's preparedness for the challenges of this century. As Acting Secretary of the Navy he held fast to the mantra of “acting, not pretending,” and thus advocated aggressively for the Navy and Marine Corps' future ― a future he believed would be defined by uncertainty and unpredictability. Every Friday he wrote a personal message to the entire Department regardless of rank. Those messages were called SECNAV Vectors. Each Vector was intended to clearly communicate his priorities and to establish a rapport with all levels of the organization. The subject of each Vector was inspired by real events that occurred in real time. As these events unfolded , the Secretary's unyielding emphasis on being prepared for unpredictable events are proven to be prescient as the Navy found itself, unintentionally, in the center of COVID-19 crisis. 1904 Battle of Port Arthur

2020 BOOTLESS PANDEMIC PANIC ON THE THEODORE ROOSEVELT.  4/4: Vectors: Heroes, Villains, and Heartbreak on the Bridge of the U.S. Navy by  Thomas B. Modly  (Author) https://www.amazon.com/Vectors-Heroes-Villains-Heartbreak-Bridge/dp/1642257036 Thomas Modly had an eclectic career in the military, academia, business, and government when he answered the call to service in 2017 and returned to the Navy where his career began. His experience, as chronicled in these pages, tells the story of Secretary Modly's quest to advance the Department of the Navy's preparedness for the challenges of this century. As Acting Secretary of the Navy he held fast to the mantra of “acting, not pretending,” and thus advocated aggressively for the Navy and Marine Corps' future ― a future he believed would be defined by uncertainty and unpredictability. Every Friday he wrote a personal message to the entire Department regardless of rank. Those messages were called SECNAV Vectors. Each Vector was intended to clearly communicate his priorities and to establish a rapport with all levels of the organization. The subject of each Vector was inspired by real events that occurred in real time. As these events unfolded , the Secretary's unyielding emphasis on being prepared for unpredictable events are proven to be prescient as the Navy found itself, unintentionally, in the center of COVID-19 crisis. 1941 California burning and sinking

QUESTIONS RAISED RE USINDOPACOM READINESS FOR COMBAT: 3/4: Vectors: Heroes, Villains, and Heartbreak on the Bridge of the U.S. Navy Hardcover – April 4, 2023 by  Thomas B. Modly  (Author) https://www.amazon.com/Vectors-Heroes-Villains-Heartbreak-Bridge/dp/1642257036 Thomas Modly had an eclectic career in the military, academia, business, and government when he answered the call to service in 2017 and returned to the Navy where his career began. His experience, as chronicled in these pages, tells the story of Secretary Modly's quest to advance the Department of the Navy's preparedness for the challenges of this century. As Acting Secretary of the Navy he held fast to the mantra of “acting, not pretending,” and thus advocated aggressively for the Navy and Marine Corps' future ― a future he believed would be defined by uncertainty and unpredictability. Every Friday he wrote a personal message to the entire Department regardless of rank. Those messages were called SECNAV Vectors. Each Vector was intended to clearly communicate his priorities and to establish a rapport with all levels of the organization. The subject of each Vector was inspired by real events that occurred in real time. As these events unfolded , the Secretary's unyielding emphasis on being prepared for unpredictable events are proven to be prescient as the Navy found itself, unintentionally, in the center of COVID-19 crisis. 1905 USN RECEPTION AT TR WHITE HOUSE: DEWEY LEADS

QUESTIONS RAISED RE USINDOPACOM READINESS FOR COMBAT: 1/4: Vectors: Heroes, Villains, and Heartbreak on the Bridge of the U.S. Navy Hardcover – April 4, 2023 by  Thomas B. Modly  (Author) https://www.amazon.com/Vectors-Heroes-Villains-Heartbreak-Bridge/dp/1642257036 Thomas Modly had an eclectic career in the military, academia, business, and government when he answered the call to service in 2017 and returned to the Navy where his career began. His experience, as chronicled in these pages, tells the story of Secretary Modly's quest to advance the Department of the Navy's preparedness for the challenges of this century. As Acting Secretary of the Navy he held fast to the mantra of “acting, not pretending,” and thus advocated aggressively for the Navy and Marine Corps' future ― a future he believed would be defined by uncertainty and unpredictability. Every Friday he wrote a personal message to the entire Department regardless of rank. Those messages were called SECNAV Vectors. Each Vector was intended to clearly communicate his priorities and to establish a rapport with all levels of the organization. The subject of each Vector was inspired by real events that occurred in real time. As these events unfolded , the Secretary's unyielding emphasis on being prepared for unpredictable events are proven to be prescient as the Navy found itself, unintentionally, in the center of COVID-19 crisis. 1939 REUBEN JAMES

QUESTIONS RAISED RE USINDOPACOM READINESS FOR COMBAT: 4/4: Vectors: Heroes, Villains, and Heartbreak on the Bridge of the U.S. Navy Hardcover – April 4, 2023 by  Thomas B. Modly  (Author) https://www.amazon.com/Vectors-Heroes-Villains-Heartbreak-Bridge/dp/1642257036 Thomas Modly had an eclectic career in the military, academia, business, and government when he answered the call to service in 2017 and returned to the Navy where his career began. His experience, as chronicled in these pages, tells the story of Secretary Modly's quest to advance the Department of the Navy's preparedness for the challenges of this century. As Acting Secretary of the Navy he held fast to the mantra of “acting, not pretending,” and thus advocated aggressively for the Navy and Marine Corps' future ― a future he believed would be defined by uncertainty and unpredictability. Every Friday he wrote a personal message to the entire Department regardless of rank. Those messages were called SECNAV Vectors. Each Vector was intended to clearly communicate his priorities and to establish a rapport with all levels of the organization. The subject of each Vector was inspired by real events that occurred in real time. As these events unfolded , the Secretary's unyielding emphasis on being prepared for unpredictable events are proven to be prescient as the Navy found itself, unintentionally, in the center of COVID-19 crisis. 1923 USS IOWA