Podcasts about pathogenic

USDA is investing significant resources to fight Highly Pathogenic Avian Influenza, or bird flu, including $100 million to develop a vaccine.

On episode #79 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 4/10/25 – 4/23/25. Hosts: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, RSS, email Become a patron of Puscast! Links for this episode Viral An ancient Epstein-Barr virus genome recovered from a museum penis gourd from Papua (JID) Patterns of Decline in Measles, Mumps, and Rubella Neutralizing Antibodies and Protection Levels Through 10 Years After a Second and Third Dose of MMR Vaccine (OFID) Tecovirimat for Clade I MPXV Infection in the Democratic Republic of Congo(NEJM) Bacterial Rapid tuberculosis diagnosis from respiratory or blood samples by a low cost, portable lab-in-tube assay(Science Translational Medicine) New handheld device can diagnose TB without a lab in under an hour, its developers say(CIDRAP) Maternal mastitis and streptococcal toxic shock syndrome risk from breastfeeding children with scarlet fever (LANCET: Infectious Diseases) Risk Factors for Mortality Among Older Adults with Hospital-Acquired Bloodstream Infections in the Intensive Care Unit(Infectious Diseases and Therapy) Bacteremia in Pediatric Solid Organ Transplant Recipients within 1 Year of Transplant(Transplant Infectious Disease) Oral gepotidacin for the treatment of uncomplicated urogenital gonorrhoea (EAGLE-1) (LANCET) Consequences of Climate Change on the Emergence of Pathogenic, Environmentally Acquired Nontuberculous Mycobacteria (OFID) Addition of Macrolide Antibiotics for Hospital Treatment of Community-Acquired Pneumonia (JID) Point-of-Care Testingby Multiplex-PCR in Different Compartments in Suspected Lower Respiratory Tract Infection After Lung Transplantation(Transplant Infectious Disease) Fungal The Last of US Season 2 (YouTube) Pathway-instructed therapeutic selection of ruxolitinib reduces neuroinflammation in fungal postinfectious inflammatory syndrome (Science Advances) Use of Dog Serologic Data for Improved Understanding of Coccidioidomycosis (JID) Parasitic Uganda launches largest malaria vaccine introduction to date(WHO: Uganda) Long-term follow-up of individuals with Chagas disease treated with posaconazole and benznidazole in a non-endemic region(CMI: Clinical Microbiology and Infection) Miscellaneous Monoclonal Antibodies From Children With Acute Kawasaki Disease Identify a Common Antigenic Target in Fatal Cases Over 5 Decades (Laboratory Investigation) Screwworm Cochliomyia hominivorax (Facebook) Music is by Ronald Jenkees Information on this podcast should not be considered as medical advice.

Dr. Paul Alexander Liberty Hour – We are killing poultry and animals in mass culling, thus causing meat/food shortages and egg shortages, which in turn lead to higher prices, placing humans in close juxtaposition with infected birds/animals, getting them infected. The push also to mass vaccinate birds and animals with a leaky imperfect vaccine with sub-optimal mounting immunity while there is circulating infection places Darwinian...

William H. Sauer, MD, FHRS, CCDS, Brigham and Women's Hospital is joined by Ezim Ajufo, MD, Brigham and Women's Hospital and Victor Nauffal, MD, Brigham and Women's Hospital to discuss the Patients with rare, pathogenic cardiomyopathy (CM) and arrhythmia variants that can present with atrial fibrillation (AF). The efficacy of AF ablation in these patients is unknown. This study tested the hypotheses that: 1) patients with a pathogenic variant in any CM or arrhythmia gene have increased recurrence following AF ablation; and 2) patients with a pathogenic variant associated with a specific gene group (arrhythmogenic left ventricular CM [ALVC], arrhythmogenic right ventricular CM, dilated CM, hypertrophic CM, or a channelopathy) have increased recurrence.  https://www.hrsonline.org/education/TheLead https://doi.org/10.1016/j.jacep.2024.06.035 Host Disclosure(s): W. Sauer: Honoraria/Speaking/Consulting: Biotronik, Biosense Webster, Inc., Abbott, Boston Scientific, Research: Medtronic   Contributor Disclosure(s): E. Ajufo: Nothing to disclose. V. Nauffal: Nothing to disclose.

The Bulletproof Dental Podcast Episode 377 HOSTS: Dr. Peter Boulden and Dr. Craig Spodak GUEST: Dr. Uche Odiatu DESCRIPTION In this conversation, Peter, Craig, and Uche discuss the importance of mindful eating and mastering food choices for better health. They explore the challenges of maintaining a healthy diet in America, the impact of the food industry on consumer choices, and the role of government regulations in food quality. The speakers delve into the intricate relationship between gut flora and food choices, emphasizing the importance of personalized nutrition and the impact of emotional regulation on overall wellness. They discuss the benefits of breastfeeding, the controversy surrounding raw milk, and the need for individuals to treat their bodies with reverence. They also discuss various aspects of men's health,  the connection between testosterone and emotional well-being, and the importance of personalized nutrition. They emphasize the need for data-driven health decisions and the role of lifestyle choices in achieving optimal health outcomes. TAKEAWAYS The food industry prioritizes taste and shelf life over nutrition. Government regulations can significantly impact food quality. Awareness of food additives is crucial for making healthier choices. Gut health plays a significant role in food cravings and overall health. Pathogenic flora can influence cravings for unhealthy foods. Personalized nutrition testing can guide dietary decisions. Emotional regulation is crucial for overall wellness. Breastfeeding has long-term benefits for emotional health. High-performance individuals need premium nutrition. The last years of life can be fulfilling with proper health choices. Probiotics are not a quick fix for gut health. Personalized nutrition is more effective than one-size-fits-all approaches. Data-driven health decisions empower individuals to make informed choices. Nutrition impacts not just physical health but emotional well-being too. The importance of maintaining a healthy lifestyle to enjoy the fruits of labor. CHAPTERS 00:00 Mindful Eating and Mastering Food Choices 02:55 The Challenges of Healthy Eating in America 08:57 Consumer Choices and Food Quality 11:53 The Role of Government in Food Regulation 15:03 The Influence of Technology on Nutrition 18:01 The Connection Between Gut Health and Cravings 25:55 The Impact of Gut Flora on Food Choices 27:32 Personalized Nutrition and Testing 29:51 The Role of Emotional Regulation in Wellness 32:01 Breastfeeding and Emotional Regulation 35:40 Reverence for the Body and High Performance 42:11 The Consequences of Poor Health Choices 45:54 The Importance of Prostate Health 49:52 The Connection Between Testosterone and Emotional Health 56:32 The Role of Data in Health Decisions REFERENCES Bulletproof Health Retreat 2025  Bulletproof Summit Bulletproof Mastermind  

A 'high pathogenic' type of bird flu was confirmed in an Otago egg farm over the weekend. To help us understand what's happening now we're joined by University of Otago virologist Jemma Geoghegan.

In this JCO Precision Oncology Article Insights episode, Miki Horiguchi summarizes two articles: “Germline Susceptibility to Renal Cell Carcinoma and Implications for Genetic Screening,” by Dr. Kate I. Glennon et al. published on August 01, 2024, and "Incidental Pathogenic Variants in Renal Cell and Urothelial Carcinoma: Is It Time for Universal Screening?” by Dr. Salvador Jaime-Casas, et al. published on August 01, 2024. TRANSCRIPT Miki Horiguchi: Hello and welcome to JCO Precision Oncology Article Insights. I'm your host Miki Horiguchi, an ASCO Journal's Editorial Fellow. Today, I'll be providing summaries of the article titled, "Germline Susceptibility to Renal Cell Carcinoma and Implications for Genetic Screening,” by Dr. Kate Glennon and colleagues. In the accompanying editorial titled, “Incidental Pathogenic Variants in Renal Cell and Urothelial Carcinoma: Is It Time for Universal Screening?” by Dr. Salvador Jaime-Casas and colleagues. Renal cell carcinoma (RCC) exhibits distinct clinical characteristics across its histological subtypes. Clear cell RCC accounts for approximately 75% of cases while the remaining non-clear cell RCC encompasses a diverse group of histology. Although a family history has been known to double the risk for RCC, genetic susceptibility, particularly across different histological subtypes and defined operations, has not been investigated well. Dr. Glennon and colleagues sought to identify risk genes for RCC within the Canadian population and investigate their clinical significance in comparison to cancer-free control populations. The authors conducted targeted sequencing of 19 RCC related genes and 27 cancer predisposition genes for 960 RCC patients in Canada. DNA samples were collected through the Ontario Tumour Bank between 2005 and 2019. For comparisons across histological subtypes, the cohort was divided into 759 patients with clear cell RCC and 201 patients with non-clear cell RCC, including all histological subtypes other than clear cell RCC. Non-cancer control data were obtained from a publicly available database which included over 118,000 cases from the European population. A total of 39 different germline pathogenic variants were identified in 56 patients representing 5.8% of the Canadian cohort. There was no significant difference in the overall number of germline pathogenic variants between the two groups. The most commonly identified germline pathogenic mutations were CHEK2, ATM/BRCA2 and MITF in the clear cell RCC group, and FH and CHEK2 in the non-clear cell RCC group. Compared to the non cancer control data, germline pathogenic variants in CHEK2 and ATM were significantly associated with an increased risk of developing clear cell RCC, while those in FH were significantly associated with non clear cell RCC. According to the bivariate association analysis between the presence of germline pathogenic variants and clinical characteristics, patients with metastatic RCC were strongly associated with pathogenic variants in BRCA1, BRCA2, and ATM. No other significant associations were observed. The authors then evaluated variations in germline pathogenic variants among RCC patients across the world using similar studies conducted in Canada, Japan, the United Kingdom, and the United States. Specifically, they compared the gene burden for significantly mutated genes in each of the cohorts against all other cohorts combined. Compared to the other cohorts, RCC patients from Japan were enriched for pathogenic variants in TP53 and depleted for pathogenic variants in CHEK2. The United States cohorts showed higher frequencies of patients with pathogenic variants in BAP1 and FH genes compared to other cohorts. In contrast, RCC patients from Canada and the United Kingdom were not enriched for any specific genes when compared with the other cohorts. After characterizing germline susceptibility to RCC, the authors evaluated how many of the RCC patients in the Canadian cohort did not meet existing referral criteria for genetic screening based on current clinical guidelines, aiming to help refine these guidelines. Among the 56 RCC patients with identified germline pathogenic variants in the Canadian cohort, 73% did not meet the referral criteria for genetic screening under current Canadian guidelines. The authors also applied the UK guidelines and the US American College of Medical Genetics guidelines to the same 56 RCC patients. Under these criteria, 80% and 64%, respectively, were not eligible for genetic screening. In an exploratory analysis, the authors examine the impact of raising the Asia onset threshold from less than 45 years to less than 50 years. This revision captured an additional five patients with pathogenic variants. In addition to more inclusive genetic screening guidelines, the study results suggest that expanding the current list of genes to include additional relevant genes such as BRCA1, BRCA2, CHEK2 and ATM could help identify more RCC patients who are affected by rare germline pathogenic variants in Canada. The authors concluded that these revisions would enable the identification of a higher number of at-risk patients and improve the management of RCC patients. In the associated editorial accompanying this research article, Dr. Salvador Jaime-Casas and colleagues emphasized that the findings from Dr. Glennon and colleagues' study are particularly worrisome as most RCC patients with incidental pathogenic variants are not being referred for genetic screening. Building on results from previous studies, the authors suggested the need to revisit and update the current screening guidelines for RCC patients. The authors also highlighted findings from other studies showing the prevalence of pathogenic variants in CHECK2, BRCA1, and BRCA2 at up to 6% in RCC patients and 11% in upper tract urothelial carcinoma patients. They noted that these rates are comparable to those of ovarian cancer and pancreatic cancer, which already have universal screening guidelines. The authors also discuss some challenges. While the prevalence of pathogenic variants is crucial for evaluating the impact of germline genetic testing, it's only one factor in devising screening guidelines for RCC and urothelial carcinoma. They emphasize the need for robust clinical trials to evaluate therapeutics targeting these pathways, as well as the importance of characterizing incidental pathogenic variants to guide patient selection for these trials. Thank you for listening to JCO Precision Oncology Article Insights and please tune in for the next topic. Don't forget to give us a rating or review and be sure to subscribe so you never miss an episode. You can find all ASCO shows at asco.org/podcasts.   The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.

The Swine Health Information Center says a case of bird flu has been detected for the first time in a pig from an Oregon Farm.

The Swine Health Information Center says a case of bird flu has been detected for the first time in a pig from an Oregon Farm.

Adam Freund (CEO) and Remi Laberge (CTO) are the founders of Arda Therapeutics, a biotechnology company developing novel therapies that selectively eliminate harmful cell populations driving chronic diseases. In this episode, they discuss their innovative approach to treating conditions like idiopathic pulmonary fibrosis by identifying and removing specific cell types that cause tissue damage, rather than trying to modify cellular behavior through traditional drug approaches.The Finer Details:The concept of pathogenic cells as drivers of chronic diseaseHow single-cell RNA sequencing enables precise identification of harmful cell populationsArda's approach to developing targeted antibody therapeuticsAdvantages of cell elimination versus pathway modificationThe potential for intermittent dosing to improve patient quality of lifeFuture applications in aging and age-related diseasesQuotes: "Cells make up tissues. Tissues make up organisms... If you have the right cell at the right place, everything looks good. If you have the wrong cell at the wrong place, doing the wrong thing, the tissue will decay.""We position our strategy as an alternative to traditional pathway targeting... changing cell behavior by blocking a single node could be quite challenging.""This is game changer for the patient experience. If we're successful, our drug will be administered once a quarter, once every six months. But during that time, this patient feels like he is not a patient. He doesn't take a drug, he's not under treatment, and doesn't have the side effect of taking those drugs.""We think that cell depletion is a broadly applicable strategy across many chronic diseases, including potentially aging itself one day.""In 10 years from now... we will know precisely which cells to eliminate. Now, will we be allowed to do it in an otherwise healthy patient? That's a different type of question."

Emile Daoud, MD, Associate Editor of JACC: Clinical Electrophysiology discusses a recently published original research paper on Clinical Characteristics and Outcomes in Patients with Atrial Fibrillation and Pathogenic TTN Variants.

With cases of H5N1 in dairy cows rapidly rising in California, animal health officials continue to try to contain the spread, and floodwaters from Hurricane Helene swamped the Southern U.S., with virtually every commodity impacted.

In this episode of the RWS Clinician's Corner, we chat with Brian Maurer, co-founder of Bristle Health and an expert in oral microbiome testing. We explore the fascinating connections between oral health and overall well-being. Brian shares groundbreaking insights into how oral bacteria can impact everything from gut health to chronic inflammation and even cardiovascular health. You'll also hear practical tips for maintaining good oral hygiene, the influence of teeth grinding, and the novel ways oral microbiome testing is transforming both consumer and practitioner approaches to health.  In this interview, we discuss:  How translocated oral bacteria can cause gut inflammation The influence of hydrochloric acid on oral bacteria translocation Case studies on oral microbiome  Various impacts of teeth grinding Links between oral bacteria and other systemic conditions Oral health tests offered by Bristle (test results, recommendations, etc.) Toothpaste options and nutrition recommendations to improve oral microbiome Timestamps:  00:00 Oral microbiome testing insights and practitioner offer. 04:26 Home oral microbiome collection with shotgun metagenomics. 07:44 Pathogenic interactions, not abundance, drive oral disease. 09:55 Assessing bacteria for tooth decay, gum disease. 15:26 Oral bacteria's role in nitric oxide production. 18:54 Health insights: scores, halitosis, gut impact, diversity. 21:57 High gum inflammation score; detailed bacterial analysis. 25:10 Clinical manifestations link oral and gut health symptoms. 27:21 Saliva tests detect comprehensive oral bacteria effectively. 32:28 Human biology reveals knowledge gaps; oral microbiome research. 35:15 H. pylori and oral bacteria transmission in families 37:36 Use mouthwash sparingly; consider diet, nutrients, xylitol. 41:24 Inflamed gut enables oral bacteria colonization. 45:23 Microbiome shifted with xylitol and lactobacillus regimen. 46:49 Clinicians need resources for interpreting test results. 49:55 Mouth breathing reduces saliva, increases oral disease. 55:48 HSA/FSA reimbursements; practitioner sign-up via Typeform. 56:39 Appreciation for innovation and thorough research updates. Speaker bio:  Brian Maurer is a Co-founder at Bristle Health. Brian received his BA in International Business from the University of San Diego. After receiving his degree, Brian spent 9 years in the commercial organization of DNA sequencing companies, driving adoption of genomic technology and applications into new and emerging markets. He has a passion for applying novel technology in healthcare to improve patient outcomes.  Connect with Brian Maurer:  Website: https://www.bristlehealth.com/ LinkedIn: https://www.linkedin.com/in/brianpmaurer/ Bristle Health is offering the test to RWS alumni at nearly 50% off ($90/test). To access it, alumni just need to sign up for our Provider Program through the link below, and the end screen will have the discount code and link to purchase: https://bristlehealth.typeform.com/to/JWRvEpws Keywords: Oral-gut bacteria translocation, oral microbiome, hydrochloric acid impact, oral dysbiosis, teeth grinding, chronic dental abscess, xylitol, Lactobacillus Reuteri, functional medicine, gum inflammation, tooth decay, bad breath types, nitric oxide production, oral health test, Bristle Health, gut health, systemic conditions, oral bacteria and gut, dental health, halitosis detection, consumer oral health test, practitioner training, H. pylori detection, toothbrush cleaning, probiotic treatment, dietary recommendations for oral health, oral microbiome research, saliva test, oral ecosystem, functional nutritionist applications Disclaimer: The views expressed in the RWS Clinician's Corner series are those of the individual speakers and interviewees, and do not necessarily reflect the views of Restorative Wellness Solutions, LLC. Restorative Wellness Solutions, LLC does not specifically endorse or approve of any of the information or opinions expressed in the RWS Clinician's Corner series. The information and opinions expressed in the RWS Clinician's Corner series are for educational purposes only and should not be construed as medical advice. If you have any medical concerns, please consult with a qualified healthcare professional. Restorative Wellness Solutions, LLC is not liable for any damages or injuries that may result from the use of the information or opinions expressed in the RWS Clinician's Corner series. By viewing or listening to this information, you agree to hold Restorative Wellness Solutions, LLC harmless from any and all claims, demands, and causes of action arising out of or in connection with your participation. Thank you for your understanding.  

The California Department of Food and Ag reports Highly Pathogenic Avian Influenza has now been confirmed in five new Central Valley dairies, and the 2024 Farm Bill's legislative logjam shows a few signs of breaking.

Three dairy herds in California's Central Valley remain under quarantine after cows tested positive for highly pathogenic avian influenza, and commodity groups join forces in Washington, DC in an effort to get a new Farm Bill passed.

In this week's episode we'll discuss how CD8+ T-cell differentiation and dysfunction inform treatment response in acute myeloid leukemia; learn more about the effect of ATM germline pathogenic variants on the outcomes in children with ataxia-telangiectasia and hematological malignancies; and discuss the preclinical efficacy of a potent, selective menin-KMT2A inhibitor JNJ-75276617 in KMT2A- and NPM1-altered leukemias.Featured Articles:CD8+ T-cell differentiation and dysfunction inform treatment response in acute myeloid leukemiaATM germ line pathogenic variants affect outcomes in children with ataxia-telangiectasia and hematologicalmalignanciesPreclinical efficacy of the potent, selective menin-KMT2A inhibitor JNJ-75276617 (bleximenib) inKMT2A- and NPM1-altered leukemias

Three of California's dairy farms report cattle infected with Highly Pathogenic Avian Influenza, and USDA Undersecretary Alexis Taylor leads a large trade mission to Vietnam this week.

Commenary by Associate Editor Sean Pinney

Over the past few years, brownspot needle blight and an assemblage of other problematic pathogenic species have garnered increasing concern in pine systems across the South. Join us as we discuss these along with current research efforts centered on this problem with Dr. John Riggins, Mississippi State University. For questions or comments, email us at timberuniversity@gmail.com

Over 200 years ago Louis Pasteur was born in Dole, France. Among Pasteur's major contributions and their benefit to society, the most important is the heat treatment of foods and beverages to reduce spoilage and eliminate pathogens for consumers. Probably the greatest achievement of Pasteur was the process that bears the name of this famous scientist who perfected the technique: pasteurization. For liquids, this process does not involve boiling the product to sterility but simply applying just enough heat (ie, par-boiling) to 50–60°C for a specified period to reduce spoilage microbes and potential pathogens. Pathogenic microbes have a lower heat tolerance than most other bacteria. Recognizing that many individuals, from the highly educated to the peasantry, were aware of the effect, it took someone like Pasteur to formalize this knowledge into specific time-temperature standards to assure consistency.  Unpasteurized foods are sold even though they have not been treated with high temperatures. Foods that haven't been pasteurized include:  raw milk some artisanal cheeses some unpasteurized versions of juices and meats Many food safety concerns and a high risk of foodborne illness are associated with eating unpasteurized foods, although there may be a few benefits. Still, evidence indicates that the health risks appear to outweigh any potential benefits in most cases. Here are the benefits and downsides of unpasteurized food products. Benefits of eating unpasteurized foods Unpasteurized food is more likely to retain its organoleptic properties and may sometimes have greater nutritional value. The term “organoleptic properties” refers to the food's taste, appearance, and smell. Exposure to high temperatures during pasteurization not only kills harmful bacteria and viruses in foods. It may also negatively affect the nutritional quality, appearance, and flavor of the food. For instance, some research demonstrated that pasteurization reduced the protective antibodies and immune-supportive vitamin C and zinc in donor human milk.  However, other research shows that these nutrient losses in human milk are minor and that the benefits of pasteurization are greater than the risks.  Downsides of eating unpasteurized foods Unpasteurized foods are associated with the occurrence of foodborne illnesses from bacteria, such as Brucella, Cryptosporidium, Listeria monocytogenes, and antibiotic-resistant Staphylococcus aureus. In particular, scientific literature frequently mentions that unpasteurized milk and dairy products are particularly high risk foods and common causes of these foodborne illnesses.  These bacterial infections may last from days to weeks. Effects range from mild symptoms — like fever, diarrhea, vomiting, muscle aches, abdominal pain, and poor appetite — to severe outcomes like miscarriage and even death.  Unpasteurized foods present even greater health risks and are more dangerous to people with compromised immune systems, such as older adults, pregnant people, young children, and those with health conditions like cancer. Summary Unpasteurized foods are slightly more likely to retain natural tastes, appearances, flavors, and nutrients, but they are strongly associated with foodborne illnesses. Evidence indicates that the risks of consuming unpasteurized foods greatly outweigh the benefits, especially for immune-compromised people.  (CREDITS)

Dr. Betsy Elsmo, an assistant professor of clinical diagnostic veterinary pathology at the Wisconsin Veterinary Diagnostic Laboratory and the University of Wisconsin School of Veterinary Medicine, and Sarah Gregory discuss infections of H5N1 bird flu in wild mammals in the United States.

BUFFALO, NY- December 15, 2023 – A new #researchpaper was #published on the #cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 23, entitled, “Uncovering a unique pathogenic mechanism of SARS-CoV-2 omicron variant: selective induction of cellular senescence.” SARS-CoV-2 variants are constantly emerging with a variety of changes in the conformation of the spike protein, resulting in alterations of virus entry mechanisms. Solely omicron variants use the endosomal clathrin-mediated entry. In this new study, researchers Franziska Hornung, Nilay Köse-Vogel, Claude Jourdan Le Saux, Antje Häder, Lea Herrmann, Luise Schulz, Lukáš Radosa, Thurid Lauf, Tim Sandhaus, Patrick Samson, Torsten Doenst, Daniel Wittschieber, Gita Mall, Bettina Löffler, and Stefanie Deinhardt-Emmer from Jena University, Leibniz Centre for Photonics in Infection Research (LPI), University of California San Francisco, Klinik für Herz- und Thoraxchirurgie, and University Hospital Bonn investigated the influence of defined altered spike formations to study their impact on premature cellular senescence. “In our study, in vitro infections of SARS-CoV-2 variants delta (B.1.617.2) and omicron (B.1.1.529) were analyzed by using human primary small alveolar epithelial cells and human ex vivo lung slices. We confirmed cellular senescence in human lungs of COVID-19 patients. Hence, global gene expression patterns of infected human primary alveolar epithelial cells were identified via mRNA sequencing.” Solely omicron variants of SARS-CoV-2 influenced the expression of cell cycle genes, highlighted by an increased p21 expression in human primary lung cells and human ex vivo lungs. Additionally, an upregulated senescence-associated secretory phenotype (SASP) was detected. Transcriptomic data indicate an increased gene expression of p16, and p38 in omicron-infected lung cells. Significant changes due to different SARS-CoV-2 infections in human primary alveolar epithelial cells with an overall impact on premature aging could be identified. A substantially different cellular response with an upregulation of cell cycle, inflammation- and integrin-associated pathways in omicron infected cells indicates premature cellular senescence. “This difference may be attributed to the distinct endocytic cell entry and intracellular pathways of the omicron variant when compared to the delta variant. The induction of cellular senescence in lung tissue following acute SARS-CoV-2 infection could potentially contribute to the reported cytokine storm and the development of long-COVID.” DOI - https://doi.org/10.18632/aging.205297 Corresponding author - Stefanie Deinhardt-Emmer - stefanie.deinhardt-emmer@med.uni-jena.de Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, SARS-CoV-2, variant of concern, cellular senescence, lung airway cells About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at https://www.Aging-US.com​​ and connect with us: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ MEDIA@IMPACTJOURNALS.COM

On today's episode we'll discuss the prognostic significance of the ETP phenotype in children with T-cell ALL, address knowledge gaps in the management of chronic granulomatous disease and learn about the effects of pathogenic and likely pathogenic variants for inherited hemostasis disorders.

References J Pharm Bioallied Sci. 2019 May; 11(Suppl 2): S135–S139. J Oral Microbiol. 2017; 9(1): 1400858. J Dent Res. 2020 Jun;99(6):644-649. Mozart WA 1782. D major, K. 385. Symphony 35 (Haffner) --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

Some people in the cannabis industry are questioning whether it is appropriate or necessary to test inhaled cannabis products for pathogenic Aspergillus.  Full disclosure, we at Medicinal Genomics sell qPCR testing kits designed to detect pathogenic Aspergillus on cannabis products. We have also published several resources on our website that describe the potential harms that can be caused by inhaling pathogenic Aspergillus spores and cite with more than 2 dozen Aspergilosis cases in cannabis users.  We have also recommended that states that are considering cannabis testing regulations adopt pathogenic Aspergillus testing. Not because we sell Aspergillus tests, but because we want to protect patients.  By almost any measure, cannabis is one of the most safe and effective medicines available. And in many cases, the potential harms that can come from using cannabis are not caused by the plant, but rather contaminants. And although cases are rare, The documented cases describing Aspergillosis deaths from contaminated cannabis vastly outnumber the published clinical risks for every other contaminant for which the cannabis industry tests. There are no documented deaths for cannabis-derived heavy metals, mycotoxins, pesticides or incorrect cannabinoid labeling. The same cannot be said  So that is our position, but of course we acknowledge that we are biased, and we are not experts on pathogenic fungi; however, our guest today is.  David W. Denning is a Professor of Infectious Diseases in Global Health at the University of Manchester in the United Kingdom. He was the founding president, executive director, and CEO of Global Action For Fungal Infections, an organization dedicated to reducing the worldwide burden of fungal disease. In 2016, he became the director of the National Aspergillosis Centre in Manchester, which treats patients with chronic pulmonary aspergillosis (CPA), and led the committee that developed the first CPA guidelines. He chairs the editorial board of a website which focusses on aspergillus and he leads an organisation which provides education on fungal diseases.  In short, Dr. Denning is the leading authority on all things Aspergillus, and we asked him many of the questions that have been debated on social media recently, including:  Should cannabis be tested for pathogenic Aspergillus Should there be an allowable limit for pathogenic Aspergillus? Is Apergillosis only a concern for immunocompromised patients?  Are the number of Aspergillosis cases under reported?  How difficult is Aspergillosis to diagnose and treat?  How ubiquitous is Aspergillus in the air we breathe?  and so much more.  Thanks to This Episode's Sponsor: Modern Canna Modern Canna is regarded as Florida's first medical cannabis laboratory and one of the most trusted third party testing providers in the United States. The company's mission is to help set the standard for cannabis testing labs worldwide by providing the most accurate and efficient testing services, delivered with a sense of compassion, integrity, and moral obligation; and to attract and attain clients who value quality data that is verifiable, reproducible, and legally defensible. Modern Canna is the only Leafly Certified laboratory in the eastern United States and adheres to the industry's strictest SOPs and quality control standards. Modern Canna offers a wide variety of testing, rapid turnaround times, and consulting services to Florida Medical Marijuana Treatment Centers (MMTC's) and hemp businesses throughout the US. Learn more at moderncanna.com Additional Resources Too Many Mouldy Joints – Marijuana and Chronic Pulmonary Aspergillosis The Aspergillus website https://en.fungaleducation.org/ Submit an Abstract for CannMed 24 Review the Podcast! CannMed Archive CannMed Community Board [Facebook Group]

As is typically the case during spring or fall, officials say the disease is likely connected to the seasonal migration of wild birds.See omnystudio.com/listener for privacy information.

Bruce Strober, MD, PhD, FAAD interviewed by Flavia Fedeles, MD, FAAD

Dr. Don and Professor Ben talk about the risks of letting your kids play on a lawn 24 hours after that lawn has been irrigated with water containing pathogenic E. coli Dr. Don - risky ☣️ Professor Ben - risky ☣️ Justin Ekins on X: “@benjaminchapman @bugcounter would it be #RiskyOrNot if my kids played on the lawn watered by this E. Coli contaminated water 24 hours after shutting off the sprinklers? https://t.co/5CKbLVELOd” / X More E. coli cases appear in Lehi; city taking steps to treat irrigation water | News, Sports, Jobs - Daily Herald Lehi City - Lehi City E. Coli Information - Lehi City Survival of Escherichia coli in the environment: fundamental and public health aspects - PMC Pressurized Irrigation - Lehi City

Dr. Wendy Puryear, a virologist at The Cummings School of Veterinary Medicine at Tufts University, and Sarah Gregory discuss the spillover of highly pathogenic avian influenza A(H5N1) into New England seals in the northeastern United States.

Today's episode is the first in a four-part series on influenza! This time we are covering just enough background information to discuss the recent H5N1 pandemic in birds, which was responsible for the egg shortage and has been killing a lot of wild birds. References: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074182/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198887/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520700/ https://www.frontiersin.org/articles/10.3389/fmolb.2021.727847/full https://jamanetwork.com/journals/jama/article-abstract/2801499 https://www.who.int/docs/default-source/wpro---documents/emergency/surveillance/avian-influenza/ai_20230331.pdf https://www.cdc.gov/flu/avianflu/reported-human-infections.htmhttps://www.cdc.gov/flu/avianflu/h5n1-animals.htm https://www.aphis.usda.gov/aphis/ourfocus/animalhealth/animal-disease-information/avian/avian-influenza/2022-hpai https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2023.28.9.2300134?crawler=true https://journals.asm.org/doi/full/10.1128/spectrum.02867-22 https://www.ecdc.europa.eu/en/news-events/efsa-ecdc-eurl-ongoing-avian-influenza-outbreaks-birds-low-risk-public https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2023.28.3.2300001 https://perspectivesinmedicine.cshlp.org/content/11/2/a038679.short https://journals.plos.org/Plospathogens/article?id=10.1371/journal.ppat.1011135

Subscribe to explore the minds of dreamers worldwide. Listen to the stories about how they are turning their dreams to reality. Pathogenic survived a tragic accident and shares his story with us. He also discusses how he found Hip Hop and became an international Battle Rapper. Support the Channel You can help us share the stories of dreamers by Supporting the channel https://paypal.me/davenoodlez CashApp: $typemedia Venmo: @stereotypeco https://www.stereotypeco.com/supports Check out Pathogenic x Stereotype x iBattle Merch https://www.stereotypeco.com/ibattletv Connect https://www.instagram.com/pathogenicgg https://twitter.com/PathogenicGG https://www.instagram.com/type88show https://www.instagram.com/davenoodlez http://www.instagram.com/stereotypeco http://www.instagram.com/awheremedia Web Design, Marketing, Branding http://www.awheremedia.com --- Send in a voice message: https://podcasters.spotify.com/pod/show/type88/message

After the gut, the second largest and most diverse microbiome in the body is located in the mouth. The oral microbiome is becoming an increasing area of interest in the medical community as research highlights several connections between chronic oral dysbiosis and systemic diseases, with inflammation being a common link. Pathogenic oral bacteria may influence inflammatory pathways particularly via the gut and by translocation through perivascular spaces. Thus, maintaining balance is the oral microbiome is a critical strategy for reducing inflammatory burden and reducing the risk of certain diseases. On this episode of Pathways to Well-Being, we welcome 2023 Annual International Conference speaker Doug Thompson, DDS, FAAMM, ABAAHP, to discuss new prevention and treatment opportunities that bridge the gap between dental care and health care. Click here to view episode transcript:https://www.ifm.org/news-insights/the-oral-microbiome-systemic-disease/

Animal and Plant Health Inspection Service Administrator Kevin Shea discusses cases of Highly Pathogenic Avian Influenza over a one-year period and trends connected to transmission to poultry via migratory and wild birds.See omnystudio.com/listener for privacy information.

We continue our study of evil in Milton's Paradise Lost, and are even more stunned at the brilliance and everyday relevance of Milton's epic poem! Find our content helpful? Why not buy us a cup of coffee! Go to: https://ko-fi.com/thechristianatheist https://www.youtube.com/c/TheChristianAtheist/featured https://www.facebook.com/JnJWiseWords https://wisewordsforyouroccasion.wordpress.com   #paradiselost #paradise #johnmilton #milton #poetry #poem #epic #epicpoem #classicpoetry #classicpoem #classics #westernliterature #satan #hell #earth #christianity #religion #thechristianatheist #drjohndwise #drjohnwise #johnwise #christian #atheist #christianity #atheism #jesus #jesuschrist #god #bible #oldtestament #newtestament #nocompromise #rationality #faith #philosophy #philosopher #culture #society #hegelism #hegel #reason #incarnation #history#psychology #theology #literature #humanities #hardquestions #postmodernism #woke #wisdom #ethics #science #poetry

Between 3 and 5% of the people living with MS are diagnosed before their sixteenth birthday. In many respects, pediatric MS is just like MS in adults. But it carries with it a distinct set of what I call social complications that can feel even more challenging to navigate than MS itself. Just think back to the awkwardness of your pre-teen and teenage years. The pressures of school, friends, and dating are a lot for any kid to contend with. And that's without having to think about living with a chronic disease like multiple sclerosis. Joining me for what I consider to be a masterclass in pediatric MS is Dr. Brenda Banwell. Dr. Banwell is Chief of the Division of Neurology and Co-Director of the Neuroscience Center at Children's Hospital of Philadelphia, and one of the foremost experts on pediatric MS in the world. We're also sharing the details of very encouraging research that sheds new light, as well as provides new evidence, about primary progressive MS, suggesting a new pathway for future treatments. We'll tell you about Healthy Aging in MS, the new clinical and research initiative at the University of Texas at Austin Dell Medical School. And we'll share what the latest research is telling us when it comes to answering the question, "Should you discontinue your disease-modifying therapy once you turn 60?" We have a lot to talk about! Are you ready for RealTalk MS??! This Week: It's a masterclass in pediatric MS  :22 Researchers take a major step forward in understanding and potentially treating primary progressive MS  2:01 University of Texas at Austin Dell Medical School launches Healthy Aging in MS initiative  6:49 Is it safe to stop your disease-modifying therapy as you age? Here's what the latest research is telling us  8:58 Dr. Brenda Banwell takes us on a deep dive into pediatric-onset MS  13:05 Share this episode  37:05 Have you downloaded the free RealTalk MS app?  37:25 SHARE THIS EPISODE OF REALTALK MS Just copy this link & paste it into your text or email: https://realtalkms.com/285 ADD YOUR VOICE TO THE CONVERSATION I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts! Email: jon@realtalkms.com Phone: (310) 526-2283 And don't forget to join us in the RealTalk MS Facebook group! LINKS If your podcast app doesn't allow you to click on these links, you'll find them in the show notes in the RealTalk MS app or at www.RealTalkMS.com STUDY:  Cerebrospinal Fluid Immunoglobulins in Primary Progressive Multiple Sclerosis are Pathogenic https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awad031/7024973 STUDY: Discontinuation of Disease-Modifying Therapy in MS Patients Over 60 Years Old and Its Impact on Relapse Rate and Disease Progression https://sciencedirect.com/science/article/abs/pii/S0303846723000288 RealTalk MS Episode 255: Aging with MS with Dr. John Corboy https://realtalkms.com/255 PEDIATRIC MS RESOURCES: National MS Society Information and Resources on Pediatric MS https://nationalmssociety.org/pediatricms Oscar the MS Monkey In-Person Camp and Retreats for Kids with MS and Their Families https://mroscarmonkey.org Network of Pediatric Multiple Sclerosis Centers https://usnpmsc.org iConquer MS Kids & Teens https://kidsandteens.iconquerms.org/kidsandteens Join the RealTalk MS Facebook Group https://facebook.com/groups/realtalkms Download the RealTalk MS App for iOS Devices https://itunes.apple.com/us/app/realtalk-ms/id1436917200 Download the RealTalk MS App for Android Deviceshttps://play.google.com/store/apps/details?id=tv.wizzard.android.realtalk Give RealTalk MS a rating and review http://www.realtalkms.com/review Follow RealTalk MS on Twitter, @RealTalkMS_jon, and subscribe to our newsletter at our website, RealTalkMS.com. RealTalk MS Episode 285 Guest: Dr. Brenda Banwell Tags: MS, MultipleSclerosis, MSResearch, MSSociety, RealTalkMS Privacy Policy

Dr. Martin Beer, a professor and head of the Institute of Diagnostic Virology at the Friedrich-Loeffler-Institute in Germany, and Sarah Gregory discuss Iceland as a stepping stone for highly pathogenic avian influenza virus between Europe and North America.

Agricultural Economics & Agribusiness Department faculty members with the University of Arkansas System, Jada Thompson and John Anderson, discuss the ongoing highly-pathogenic avian influenza outbreak and its impact on egg prices.

And the virus isn't showing signs of weakening.

3.01 Bacteria Basics   Microbio review for the USMLE Step 1 Exam: Bacteria are single-celled organisms that can cause infection Structural components of bacteria include: capsule, cell wall, flagella, fimbriae, plasma membrane, ribosomes, endospores, and DNA Capsules help bacteria evade the immune system by inhibiting phagocytes Flagella are tail-like appendages that allow bacteria to move, fimbriae help bacteria adhere to surfaces Most bacteria have a cell wall, which can be either gram positive or gram negative Plasma membrane is composed of proteins and phospholipids and performs various functions DNA is the genetic material, ribosomes are used to build proteins, some bacteria have endospores which are heat-resistant resting cells Bacteria can be classified by cell wall composition, morphology, metabolism, and based on their ability to grow at different temperatures and pH levels Gram staining is a laboratory technique used to differentiate between gram positive and gram negative bacteria Morphology of bacteria includes cocci (spherical), bacilli (rod-shaped), and spirilla (spiral-shaped) Metabolism of bacteria can be aerobic (uses oxygen) or anaerobic (doesn't use oxygen) Temperature and pH ranges at which bacteria can grow vary widely, some can grow at extreme conditions Pathogenic bacteria cause disease, while non-pathogenic bacteria do not Bacteria can be treated with antibiotics, but overuse can lead to antibiotic resistance

How do the microbes in our gut impact autoimmunity, hormones, cardiovascular health, and inflammation? What can be done to bring our gut back into balance for long term health? Today's guest is one of our integrative and functional nutritionists, Araceli Benavides. Araceli is an Institute for Functional Medicine certified practitioner who works with her patients to get to the root cause of conditions including autoimmunity, small intestinal bacterial overgrowth, dysbiosis and more. We hope you enjoy this conversation about how our gut microbiome is connected to chronic diseases and how Araceli works with her patients to identify root causes of autoimmunity, hormone imbalance, and inflammatory diseases. Timestamps: 0:00 - Introductions 2:58 - What is the microbiome and why is it important? 3:41 - How does microbiome impact disease? 5:13 - Symptoms that can be connected to the microbiome 6:15 - What is leaky gut? 8:20 - What is functional gut testing? 10:11 - Evaluation of gut health without testing 11:11 - How common is leaky gut? 12:49 - Connections to cardiovascular disease 14:17 - Connections to cancer 15:28 - Connections to Autoimmunity 17:15 - Connections to mood disorders 20:11 - Pathogenic bacteria and disease 21:19 - Diet and supplements for gut health 24:30 - Vagus nerve and gut health 26:54 - Top foods for gut health 29:08 - Food bacteria and why they are helpful for gut health 32:55 - Retesting for gut health 37:51 - One thing under $20 that has helped Araceli's health

More than 1 million chickens will have to be destroyed.

In this episode of SurgOnc Today®, Doreen Agnese, MD, from The Ohio State University Medical Center is joined by Toan Nguyen, MD, from Lakeland Regional Health and Mark Robson, MD, from Memorial Sloan Kettering Cancer Center. Realizing that genetic testing is being performed more frequently and by many different providers for patients both with and without breast cancer, they discuss the management of non-BRCA breast cancer susceptibility genes.

The CardioNerds Cardiovascular Genomics Series continues! In this episode Dr. Dan Ambinder (CardioNerds Cofounder and Interventional Cardiologist), Dr. Anjali Wagle (FIT Ambassador at Johns Hopkins) and Dr. James Sampognaro (medicine resident at Johns Hopkins Osler Medicine Residency) learn from Dr. Allison Hays (Associate Professor of Medicine, Division of Cardiology, Johns Hopkins CMR researcher and Medical Director of Echocardiography) and Dr. Cindy James (Associate Professor of Medicine and certified genetic counselor at Johns Hopkins with research focusing on cardiovascular genetic counseling and arrhythmogenic cardiomyopathies). They discuss arrhythmogenic RV cardiomyopathy as the context to learn about genetic counseling and family screening.  Episode script and notes were developed by Dr. Anjali Wagle. Audio editing by CardioNerds Academy Intern, student doctor Chelsea Amo Tweneboah. This episode was developed in collaboration with the American Society of Preventive Cardiology and is supported with unrestricted educational funds from Illumina, Inc. All CardioNerds content is planned, produced, and reviewed solely by CardioNerds. This CardioNerds Cardiovascular Genomics series is a multi-institutional collaboration made possible by contributions of stellar fellow leads and expert faculty from several programs. Check out this REVIEW describing the “Multimodality Imaging in Arrhythmogenic Right Ventricular Cardiomyopathy” by Nitin Malik, Allison Hays, and colleagues.   For related episodes, please enjoy these case-based discussions:  Ep 56. Case Report: Arrhythmogenic Desmoplakin Cardiomyopathy – Northwestern University  Ep 74. Case Report: Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) – Summa Health  Pearls • Notes • References CardioNerds Cardiovascular Genomics PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Show notes - Genetic Counseling & Family Screening in Arrhythmogenic Cardiomyopathies Notes (developed by Dr. Anjali Wagle)   What is the underlying pathophysiology of arrhythmogenic RV cardiomyopathy (ARVC)?  Fibrofatty replacement cardiac myocytes  Associated with genetically mediated disruption of desmosomal proteins   This leads to thinning and weakness of the heart that can lead to aneurysms and progressive dilatation and failure of the right ventricle (RV)  How is ARVC diagnosed?  2010 taskforce criteria (Marcus et al, 2010):    RV structural abnormalities including findings seen on echocardiogram, MRI, and RV angiography  Pathological criteria  Repolarization abnormalities   Depolarization/conduction abnormalities   Ventricular arrhythmias   Genetics and/or family history   How does ARVC present?   Young, healthy individual will have symptoms of arrhythmias (syncope, pre-syncope, SCD) or heart failure  Family screening   What are the inheritance and genetic factors of ARVC?  Autosomal dominant pattern  Low penetrance and variable expressivity   Half of patients who are index cases will be found to have a mutation in the desmosomal gene.   What are the most common mutations associated with ARVC?  Most commonly the genes involved are plakophilin-2 (PKP-2) and desmoplakin.   For PKP-2 the most common mutations are truncating mutations.   In patients who have inherited two truncating mutations, this will result in neonatal lethality.   Is there a difference in the genetic factors of left and right arrhythmogenic cardiomyopathy?   ACM is disproportionally a right dominated cardiomyopathy. Left dominated cardiomyopathy has a different genetic profile.   Pathogenic variants in desmoplakin disproportionally cause biventricular forms of ACM or left dominated forms.  

The field of Cardiovascular Genomics has advanced tremendously over the past two decades, having a significant clinical impact and changing the perception of the role and scope of genetic testing in several cardiovascular domains.  To kickstart the Cardiovascular Genomics series, CardioNerds Dr. Sara Coles (FIT at Duke University), Dr. Colin Blumenthal (CardioNerds Academy faculty and FIT at UPenn), and Dr. Karla Asturias (CardioNerds Academy fellow and medicine resident at Pennsylvania Hospital) have a great discussion with Dr. James Daubert, a clinical electrophysiologist at Duke University, with a particular interest in inherited arrhythmia syndromes and sports cardiology. In this episode, we review basic concepts of cardiovascular genomics and genetics in electrophysiology while discussing when to (and when not to!) test our patients and their families and how to approach those results. Audio editing by CardioNerds academy intern, Pace Wetstein. This episode was developed in collaboration with the American Society of Preventive Cardiology and is supported with unrestricted educational funds from Illumina, Inc. All CardioNerds content is planned, produced, and reviewed solely by CardioNerds. This CardioNerds Cardiovascular Genomics series is a multi-institutional collaboration made possible by contributions of stellar fellow leads and expert faculty from several programs. Pearls • Notes • References CardioNerds Cardiovascular Genomics PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls and Quotes - Genetics in Electrophysiology The first step is identifying the right phenotype! Getting the right phenotype is crucial, as genetic testing done in a patient without a clear phenotype (or an incorrect one) would lead to significant anxiety, unnecessary tests and interventions, and potentially misleading and dangerous conclusions for patients and their families. Genetic testing typically should be reserved for patients with a confirmed or suspected diagnosis of an inherited disease or for individuals with a previously diagnosed pathogenic variant in a first-degree relative.1 Discuss with your patient! Genetic counseling is essential and recommended for all patients before and after genetic testing. It should include a thorough discussion of risks, benefits, and possible outcomes, including variants of uncertain significance.2 Cardiovascular genetics is a dynamic and rapidly evolving field. New information can cause a variant of uncertain significance to be reclassified as a pathogenic or likely pathogenic variant or to be downgraded to benign or likely benign as variant databases expand. Another possibility is that new research might identify novel genes for a particular disease, which could warrant retesting, particularly for phenotype-positive and genotype-negative patients.1 Brugada syndrome is an inherited arrhythmogenic disorder characterized by ST-segment elevation in the right precordial leads and malignant ventricular arrhythmias, with occasional conduction disease and atrial arrhythmias. It is diagnosed in patients with ST-segment elevation ≥ 2 mm in ≥ 1 lead among the right precordial leads, with a type I morphology (J-point elevation with slowly descending or concave ST segment elevation merging into a negative T wave), shown in the image below. This pattern can be observed spontaneously or after provocative drug testing (e.g., procainamide). Pathogenic genetic variants in SCN5A that result in loss of function of the cardiac sodium channel are identified in approximately 20% of cases.3,4 Image adapted from Batchvarov VN. The Brugada Syndrome – Diagnosis, Clinical Implications and Risk Stratification. Eur Cardiol Rev. 2014;9(2):82. doi:10.15420/ECR.2014.9.2.82 Measure the QT interval yourself!

In this episode of Delta's Duck Hunter Podcast, host Joel Brice gets an update on HPAI (Highly Pathogenic Avian Influenza (aka. Bird flu)) in North America from Dr. Andrew Ramey, Director of the Molecular Ecology Lab at the US Geological Survey, Alaska Science Center in Anchorage AK. They discuss the level of threat to duck hunters as the season begins, what to do if you encounter an animal you suspect may be infected, and why this is an issue the Government is keeping an eye on. For the Must-Know items about HPAI click here: https://deltawaterfowl.org/what-every-hunter-should-know-about-the-bird-flu/

Commentary by Dr. Valentin Fuster

Climate change is worsening more than half of all known human pathogenic diseases -- including those spread by mosquitoes and ticks in Minnesota.

Welcome to another episode of the Dr. Lo Radio Show! I really enjoyed recording this episode, and I think you will enjoy it as well. Today I am chatting with Holly Howe and we are talking all about why fermented foods are a great addition to better your gut health. Holly Howe is a Fermentation Educator, cookbook author, photographer and blogger with a goal to have sauerkraut fermenting in 100,000 homes. In 2014, Holly launched “MakeSaurkraut!” her fermentation website with everything you need to know to successfully ferment sauerkraut that you and your loved ones will enjoy eating. Holly also teaches how to ferment other vegetables and fruits and how fermented foods can effortlessly—and flavorfully—improve your gut health. Holly believes that food is to be enjoyed and to also serve you. We talk about so many great things in this episode. We talk about the origin of fermented foods. We also talk about the benefits fermented foods, like sauerkraut, have on the good bacteria in your microbiome. We talk about the importance of taking control of your own health, the energy-boosting benefits of fermented foods, how to make your own sauerkraut and the comparison between fermented & non-fermented foods. If you are listening to this episode and you or someone you know is navigating through any of the health issues we discuss, I would be more than happy to support you in the journey! I work with people virtually and in-person in San Diego. Feel free to reach out to me to continue this conversation: @doctor_lo I hope you enjoy and learn something new from this episode! We Discuss: {07:03} History of Fermenting Foods {10:57} Pathogenic bacterias will not survive in sauerkraut brine {11:40} The shelf life of sauerkraut {14:42} Other types of vegetables that can also be made into sauerkraut {16:02} Empowerment and connecting with food {17:07} Our body's messages {19:42} Experience of a man in hemodialysis {22:28} On re-training the tongue {24:12} Testing patients for leaky gut {26:46} It's not what you eat, it's what you absorb {30:47} The salty environment will lead the way in fermentation {31:54} No need to add fluids because the salt will pull out the liquids And so much more! Links Mentioned: Guest Website https://www.makesauerkraut.com/about/ Guest on Instagram https://www.instagram.com/makesauerkraut/ Shine Natural Medicine https://shinenaturalmedicine.com/ Paleovalley https://paleovalley.com/ 15% off with CODE: DRLO

What's the next big leap in medicine? Nature may have more to offer than one may think. Listen up to learn: How an ordinarily innocuous bacteria can become dangerous Why antibiotics may fall short What a biofilm is Offer: This episode is sponsored by Bowmar Nutrition. To receive a 5% discount, use the code GENIUS5 at checkout. Go to BowmarNutrition.com to shop now! Cassandra Leah Quave, an associate professor in the department of dermatology at Emery University, shares her quest for nature's next medicines. Nature has offered treatments and medicines since ancient times. However, with increasingly resilient bacteria, viruses, and other conditions, new solutions need to be found. These solutions may come in the form of new solutions found in nature for biofilm-related infections and highly drug-resistant conditions. The possible impact of anti-biofilm technology has tremendous potential, especially in quorum sensing and other stubborn conditions. Visit https://cassandraquave.com to learn more. Episode also available on Apple Podcast: http://apple.co/30PvU9C

The pathways used by evil are becoming more apparent. The legal fights continue in a mix frustration and determination. There's two ways this can go. Work day birthday. The back burner is where they put everything. Follow the Constitution or GTFO. Trump speaks to the youth. Can you imagine Brandon doing this interview? The sponsor drop challenge. Economic growth was the best in the world. The best answer to everything is education. Florida leads the way, again. It's tough looking back on history and then living it. The planned path to human destruction. Random samples and lots of them. Meningeal signs, damaged VAXT immunity, atypical symptoms, dumb docs, scattered blood work, medical system compromises, stiff necks and sudden death. It's time to educate yourself on treatment of the VAXT we love. They may hate you for avoiding harm, but we must now consider how best to help those that didn't. Learn more about your ad choices. Visit megaphone.fm/adchoices