Podcasts about Artemisinin

Group of drugs used against malaria

  • 49PODCASTS
  • 71EPISODES
  • 24mAVG DURATION
  • ?INFREQUENT EPISODES
  • Feb 8, 2025LATEST

POPULARITY

20172018201920202021202220232024


Best podcasts about Artemisinin

Latest podcast episodes about Artemisinin

Tick Boot Camp
Episode 449: Kicking Sick: Your Go-to Guide for Thriving with Chronic Health Conditions - an interview with Amy Kurtz

Tick Boot Camp

Play Episode Listen Later Feb 8, 2025 95:49


In this inspiring episode of our Tick Boot Camp Podcast, we welcome Amy Kurtz, holistic health coach, patient advocate, and author of Kicking Sick: Your Go-to Guide for Thriving with Chronic Health Conditions. Amy shares her incredible journey from years of undiagnosed illness to finding hope, healing, and purpose. Her story offers practical advice, emotional support, and empowerment for anyone navigating chronic health challenges. Episode Highlights:

The Jordan Harbinger Show
1085: Traditional Chinese Medicine | Skeptical Sunday

The Jordan Harbinger Show

Play Episode Listen Later Dec 1, 2024 57:58 Transcription Available


From Mao to Main Street: Michael Regilio unravels the surprising story behind Traditional Chinese Medicine's global rise on this week's Skeptical Sunday! Welcome to Skeptical Sunday, a special edition of The Jordan Harbinger Show where Jordan and a guest break down a topic that you may have never thought about, open things up, and debunk common misconceptions. This time around, we’re joined by skeptic, comedian, and podcaster Michael Regilio! On This Week's Skeptical Sunday: The modern global presence of TCM (traditional Chinese medicine) is largely a result of political necessity rather than proven effectiveness. Surprisingly, it had been largely abandoned in China by the 1800s until Chairman Mao revived it in the 1960s as a solution to healthcare shortages — despite not personally believing in it himself. The scientific foundation of TCM's core concepts — chi, yin/yang balance, and meridians — remains unproven. Studies attempting to validate these practices face significant challenges, including the impossibility of true double-blind trials and concerns about data reliability, particularly in Chinese research where regulators found over 80% of clinical trial data to be fabricated. Acupuncture's effectiveness appears largely tied to the placebo effect, though this shouldn't be dismissed. Studies show "sham" acupuncture (needles placed randomly) produces similar results to "real" acupuncture, suggesting the specific placement of needles according to meridian theory may be less important than the overall experience and belief in the treatment. Cupping, while popularized by athletes like Michael Phelps, essentially creates controlled tissue damage through suction. Though it may temporarily increase blood flow, it can cause permanent skin damage if done repeatedly and may aggravate existing skin conditions. Chinese herbal medicine represents a bright spot in the TCM landscape, built on 500 million years of plant evolution and chemical development. Some traditional remedies have led to breakthrough modern treatments, like Artemisinin for malaria, showing how ancient wisdom can guide modern medical discoveries when subjected to rigorous scientific testing. This suggests that while we should approach traditional practices with skepticism, we shouldn't dismiss them entirely — instead, we can use modern scientific methods to identify and develop valuable treatments from traditional knowledge. Connect with Jordan on Twitter, Instagram, and YouTube. If you have something you'd like us to tackle here on Skeptical Sunday, drop Jordan a line at jordan@jordanharbinger.com and let him know! Connect with Michael Regilio at Twitter, Instagram, and YouTube,...

Science in Action
Destination Asteroid Apophis

Science in Action

Play Episode Listen Later Jul 18, 2024 33:53


There's an update from asteroid expert Patrick Michel about the European Space Agency's Rapid Apophis Mission for Space Safety. The ESA have received permission to begin preparatory work for the planetary defence mission which will rendezvous with the asteroid Apophis, that will be passing by the Earth on Friday, April 13th 2029. And in news from the Moon this week – a massive cave has been discovered on its surface that might be a window into the body's sub-surface, and even a ready-made lunar base for future astronauts to use. The claim was made in Nature Astronomy by a team of Italian planetary scientists, and two experts in remote sensing who have been re-interpreting radar data from a NASA orbiter - Leonardo Carrer and Lorenzo Bruzzone from University of Trento in Italy. In the magazine Science, there's a call for a re-doubling of efforts to tackle malaria in Africa as signs grow that a leading treatment, Artemisinin, is becoming less effective. Deus Ishengoma, a malaria expert with the Tanzanian National Institute for Medical Research, is worried, having seen the transformation Artemesinin made in the past. Tiny solar-powered flying robots - an ultra-lightweight, solar-powered micro aerial vehicle capable of sustained flight is described in a paper published in Nature. Peng Jinzhe of the School of Energy and Power Engineering at Beihang University was part of the team behind the 8 millimetre robot. Presenter: Roland Pease Producer: Jonathan Blackwell Production Coordinator: Jana Bennett-Holesworth (Image: ESA's Ramses mission to asteroid Apophis. Credit: The European Space Agency)

I AM BIO
The Synbio Revolution is Here (REDUX)

I AM BIO

Play Episode Listen Later Jan 23, 2024 26:14


Innovative companies are using synthetic biology to engineer organisms and create new materials that could transform every sector of our economy, from health care to food and energy production. Those companies say we've entered a synbio revolution, and it holds potential to improve the health of people and our planet. In this episode, we talk with three synbio experts about how this convergence of genetic engineering, computer science and other scientific disciplines is making our world more sustainable. Follow us on LinkedIn, X, Facebook and Instagram. Visit us at https://www.bio.org/

I AM BIO
The Synbio Revolution is Here

I AM BIO

Play Episode Listen Later Oct 31, 2023 26:14


Follow us on LinkedIn, X, Facebook and Instagram. Visit us at https://www.bio.org/Innovative companies are using synthetic biology to engineer organisms and create new materials that could transform every sector of our economy, from health care to food and energy production. Those companies say we've entered a synbio revolution, and it holds potential to improve the health of people and our planet. In this episode, we talk with three synbio experts about how this convergence of genetic engineering, computer science and other scientific disciplines is making our world more sustainable. 

Johns Hopkins Malaria Research Institute Podcast
Is Artemisinin Drug Resistance in Africa on the Rise?

Johns Hopkins Malaria Research Institute Podcast

Play Episode Listen Later Oct 9, 2023 1:08


Researchers examine the rise of artemisinin drug resistance in Eritrea - and search for its genetic basis. Transcript Artemisinin – a key antimalarial drug – and other drugs derived from it, are fast losing their effectiveness across South East Asia and increasingly in Africa, too. To investigate this, researchers conducted a review of drug efficacy studies in the East African country of Eritrea. They looked for the rates of delayed parasite clearance in the three days following treatment – a key marker of partial drug resistance. They found a troubling pattern: delayed parasite clearance climbed from 0.4% in 2016 to 1.9% in 2017, followed by a marked increase to 4.2% in 2019. By isolating and sequencing parasitic DNA, they found that this trend was associated with the rise of a novel mutation to the Kelch13 region of the parasite, called R622I. Given the lack of alternative drugs, the emergence of resistance in Africa is concerning. Source Increasing Prevalence of Artemisinin-Resistant HRP2-Negative Malaria in Eritrea About The Podcast The Johns Hopkins Malaria Minute podcast is produced by the Johns Hopkins Malaria Research Institute to highlight impactful malaria research and to share it with the global community.

Kraut im Ohr - Dein Wildkräuter Podcast
Kraut-Interview: Hannelore Klabes, große alte Dame der Artemisia Annua

Kraut im Ohr - Dein Wildkräuter Podcast

Play Episode Listen Later Jun 29, 2023 28:23


Hannelore Klabes ist mit ihren 94 Jahren die wohl älteste Frau, die wir bisher vorm Mikro hatten. Und ein lebender - ja ein absolut agiler Beweis dafür, dass man mit Wildpflanzen gut und gesund altern kann. Hannelore Klabes ist Expertin für die Artemisia Annua, dem einjährigen Beifuss. Außerdem eine Weltenbummlerin und seit ihrem vermeintlichen Ruhestand ständig auf Achse - mit langen Aufenthalten, vor allem in Afrika. Heute gehen wir ein Stück des Wegs mit ihr und verfolgen mit kriminalistischem Spürsinn, wie sie sozusagen zunächst im Alleingang die Artemisa-Art in Afrika angesiedelt hat. Hinweis: Frau Klabes spricht von "Behindertenzentrum" und meint das absolut wertschätzend. In dieser Folge sprechen wir darüber:

The Common Sense MD
Fenbendazole For Cancer?

The Common Sense MD

Play Episode Listen Later May 16, 2023 17:15


In this episode of The Common Sense MD, Dr. Rogers goes over the controversial alternative cancer treatments Fenbendazole and Artemisinin. What did you think of this episode of the podcast? Let us know by leaving a review! Connect with Performance Medicine! Sign up for our weekly newsletter: https://performancemedicine.net/doctors-note-sign-up/ Facebook: @PMedicine Instagram: @PerformancemedicineTN YouTube: Performance Medicine

Johns Hopkins Malaria Research Institute Podcast
KIC5: A New Piece in the Puzzle of Artemisinin Resistance

Johns Hopkins Malaria Research Institute Podcast

Play Episode Listen Later Feb 13, 2023 1:07


Drug resistance is on the rise, but genetics can help us understand what's driving it. Here, researchers identify a protein associated with resistance to artemisinin, a key malaria drug. Transcript Artemisinin-based combination therapies (ACT) are considered the most effective method to treat malaria. Yet drug resistance to them is on the rise, spreading from Southeast Asia to Africa, becoming a real problem. A genetic approach to drug resistance can help us understand the genes responsible for this. Artemisinin resistance has long been associated with mutations to a protein called Kelch13. By screening the parasite genome, researchers have identified another protein associated with resistance to the drug. Called KIC5, this protein helps maintain nuclear homeostasis – balance within the parasite's cell – as it lives in human red blood cells. When expressed, it helps the parasite overcome artemisinin stress by supporting DNA repair and other mitochondrial activity. But when it's disrupted, the parasite can't deal with this stress and becomes sensitized to the drug. Almost like flipping a switch, disrupting KIC5 makes artemisinin work again. Source Protein KIC5 is a novel regulator of artemisinin stress response in the malaria parasite Plasmodium falciparum About The Podcast The Johns Hopkins Malaria Minute podcast is produced by the Johns Hopkins Malaria Research Institute to highlight impactful malaria research and to share it with the global community.

PaperPlayer biorxiv cell biology
The Kelch13 compartment is a hub of highly divergent vesicle trafficking proteins in malaria parasites

PaperPlayer biorxiv cell biology

Play Episode Listen Later Dec 15, 2022


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.15.520209v1?rss=1 Authors: Schmidt, S., Wichers-Misterek, J. S., Behrens, H. M., Birnbaum, J., Henshall, I., Jonscher, E., Flemming, S., Castro-Pena, C., Spielmann, T. Abstract: Single amino acid changes in the parasite protein Kelch13 (K13) result in reduced susceptibility of P. falciparum parasites to Artemisinin and its derivatives (ART). Recent work indicated that K13 and other proteins co-localising with K13 (K13 compartment proteins) are involved in the endocytic uptake of host cell cytosol (HCCU) and that a reduction in HCCU results in ART resistance. HCCU is critical for parasite survival but is poorly understood, with the K13 compartment proteins are among the few proteins so far functionally linked to this process. Here we further defined the composition of the K13 compartment by identifying four novel proteins at this site. Functional analyses, tests for ART susceptibility as well as comparisons of structural similarities using AlphaFold2 predictions of these, and previously identified proteins, showed that canonical vesicle trafficking and endocytosis domains were frequent in proteins involved in resistance and endocytosis, strengthening the link to endocytosis. Despite this, most showed unusual domain combinations and large parasite-specific regions, indicating a high level of taxon-specific adaptation. A second group of proteins did not influence endocytosis or ART resistance and was characterised by a lack of vesicle trafficking domains. We here identified the first essential protein of the second group and showed that it is needed in late-stage parasites. Overall, this work identified novel proteins functioning in endocytosis and at the K13 compartment. Together with comparisons of structural predictions it provides a repertoire of functional domains at the K13 compartment that indicate a high level of adaption of the endocytosis in malaria parasites. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Bible Prophecy Talk - End Times Podcast and News
A Theory About Cancer and Parasites

Bible Prophecy Talk - End Times Podcast and News

Play Episode Listen Later Dec 11, 2022 55:11


Show Notes: Metabolic Theory of Cancer Dr. Thomas Seyfried https://www.youtube.com/watch?v=06e-PwhmSq8 Jeffery Dach MD – 2 Part Slide Presentation: https://jeffreydachmd.com/2021/03/cracking-cancer-toolkit-slide-presentation/  Cracking Cancer Toolkit by Jeffery Dach MD (KINDLE VERSION for search) https://www.amazon.com/Cracking-Cancer-Toolkit-Repurposed-Treatment-ebook/dp/B08PDQV28K Antiparasitic Drugs and Cancer Artemisinin Pubmed keywords “Artemisnin Cancer” https://pubmed.ncbi.nlm.nih.gov/?term=artemisinin+cancer University of Kentucky using Atermisinin for Cancer / Covid https://www.youtube.com/watch?v=3fSAQorkDqc&t=4s Artemisinin our Ultimate Cancer … Continue reading "A Theory About Cancer and Parasites"

Nowhere to Run
A Theory About Cancer and Parasites

Nowhere to Run

Play Episode Listen Later Dec 11, 2022 55:11


Show Notes: Metabolic Theory of Cancer Dr. Thomas Seyfriedhttps://www.youtube.com/watch?v=06e-PwhmSq8Jeffery Dach MD – 2 Part Slide Presentation: https://jeffreydachmd.com/2021/03/cracking-cancer-toolkit-slide-presentation/ Cracking Cancer Toolkit by Jeffery Dach MD (KINDLE VERSION for search) https://www.amazon.com/Cracking-Cancer-Toolkit-Repurposed-Treatment-ebook/dp/B08PDQV28K Antiparasitic Drugs and Cancer Artemisinin Pubmed keywords “Artemisnin Cancer” https://pubmed.ncbi.nlm.nih.gov/?term=artemisinin+cancer University of Kentucky using Atermisinin for Cancer / Covid https://www.youtube.com/watch?v=3fSAQorkDqc&t=4s Artemisinin our Ultimate Cancer Weapon a Gift […]

Revelations Radio Network
A Theory About Cancer and Parasites

Revelations Radio Network

Play Episode Listen Later Dec 11, 2022


Show Notes: Metabolic Theory of Cancer Dr. Thomas Seyfried https://www.youtube.com/watch?v=06e-PwhmSq8 Jeffery Dach MD – 2 Part Slide Presentation: https://jeffreydachmd.com/2021/03/cracking-cancer-toolkit-slide-presentation/  Cracking Cancer Toolkit by Jeffery Dach MD (KINDLE VERSION for search) https://www.amazon.com/Cracking-Cancer-Toolkit-Repurposed-Treatment-ebook/dp/B08PDQV28K Antiparasitic Drugs and Cancer Artemisinin Pubmed keywords “Artemisnin Cancer” https://pubmed.ncbi.nlm.nih.gov/?term=artemisinin+cancer University of Kentucky using Atermisinin for Cancer / Covid https://www.youtube.com/watch?v=3fSAQorkDqc&t=4s Artemisinin our Ultimate Cancer … Continue reading "A Theory About Cancer and Parasites"

Revelations Radio Network
A Theory About Cancer and Parasites

Revelations Radio Network

Play Episode Listen Later Dec 11, 2022


Show Notes: Metabolic Theory of Cancer Dr. Thomas Seyfried https://www.youtube.com/watch?v=06e-PwhmSq8 Jeffery Dach MD – 2 Part Slide Presentation: https://jeffreydachmd.com/2021/03/cracking-cancer-toolkit-slide-presentation/  Cracking Cancer Toolkit by Jeffery Dach MD (KINDLE VERSION for search) https://www.amazon.com/Cracking-Cancer-Toolkit-Repurposed-Treatment-ebook/dp/B08PDQV28K Antiparasitic Drugs and Cancer Artemisinin Pubmed keywords “Artemisnin Cancer” https://pubmed.ncbi.nlm.nih.gov/?term=artemisinin+cancer University of Kentucky using Atermisinin for Cancer / Covid https://www.youtube.com/watch?v=3fSAQorkDqc&t=4s Artemisinin our Ultimate Cancer … Continue reading "A Theory About Cancer and Parasites"

apolut: Standpunkte
Eine Pflanze als Corona-Heilmittel? | Von Susanne Wolf

apolut: Standpunkte

Play Episode Listen Later Jun 24, 2022 15:42


Seit mehr als zwei Jahren ist Artemisia Annua (einjähriger Beifuß) als mögliches Heilmittel bei Covid-19 im Gespräch, doch Studien dazu versanden oder werden gar nicht erst finanziert. Pharmaindustrie, Politik und WHO spielen dabei eine zweifelhafte Rolle.Ein Standpunkt von Susanne Wolf.„Kräutertrank aus Afrika soll gegen Corona helfen“, „Vermeintliches Heilmittel gegen Corona“, „Angebliches Covid-Wundermittel“ – so titelten einige Medien im Frühsommer 2020. Die Rede war von Covid Organics, einem Getränk, das von Madagaskars Präsident Andry Rajoelina als Heilmittel gegen Covid-19 präsentiert wurde. Der Kräutertrunk wurde vom Madagassischen Institut für Angewandte Forschung entwickelt, das bereits mehrere international erfolgreiche Heilmittel entwickelt hatte. Weitere afrikanische Staaten wie Tansania, der Kongo oder die Zentralafrikanische Republik bestellten Covid Organics – die Skepsis in westlichen Medien war groß.Kein Geld für ForschungDer Hauptinhaltsstoff von Covid Organics ist Artemisia Annua oder einjähriger Beifuß, eine Heilpflanze, die in gemäßigten Breitengraden wächst und auch in Europa angebaut werden kann. Die chinesische Pharmakologin Dr. Youyou Tu machte bereits im Jahr 1972 Artemisinin als wichtigsten Wirkstoff gegen Malaria aus, 2015 bekam sie für ihre Forschung den Medizinnobelpreis. Weitere Studien ergaben die Wirksamkeit von Artemisia Annua auch bei Krebserkrankungen, Borreliose oder Diabetes. Praktiker der Traditionellen Chinesischen Medizin wissen seit Jahrtausenden um dessen antivirale und fiebersenkende Wirkung.... hier weiterlesen: https://apolut.net/eine-pflanze-als-corona-heilmittel-von-susanne-wolf/+++Apolut ist auch als kostenlose App für Android- und iOS-Geräte verfügbar! Über unsere Homepage kommen Sie zu den Stores von Apple und Huawei. Hier der Link: https://apolut.net/app/Die apolut-App steht auch zum Download (als sogenannte Standalone- oder APK-App) auf unserer Homepage zur Verfügung. Mit diesem Link können Sie die App auf Ihr Smartphone herunterladen: https://apolut.net/apolut_app.apk+++Abonnieren Sie jetzt den apolut-Newsletter: https://apolut.net/newsletter/+++Ihnen gefällt unser Programm? Informationen zu Unterstützungsmöglichkeiten finden Sie hier: https://apolut.net/unterstuetzen/+++Unterstützung für apolut kann auch als Kleidung getragen werden! Hier der Link zu unserem Fan-Shop: https://harlekinshop.com/pages/apolut+++Website und Social Media:Website: https://apolut.net/Odysee: https://odysee.com/@apolut:aRumble: https://rumble.com/ApolutInstagram: https://www.instagram.com/apolut_net/Gettr: https://gettr.com/user/apolut_netTelegram: https://t.me/s/apolutFacebook: https://www.facebook.com/apolut/Soundcloud: https://soundcloud.com/apolut See acast.com/privacy for privacy and opt-out information.

Infectious Diseases
P. Malhotra - Unravelling the mode of actions of two currentantimalarial: Chloroquine & Artemisinin

Infectious Diseases

Play Episode Listen Later Mar 11, 2022 40:48


Pawan Malhotra, Malaria Group, International Centre for Genetic Engineering and Biotechnology, New Delhi , INDIA speaks on "Unravelling the mode of actions of two currentantimalarial: Chloroquine & Artemisinin".

Footprints
Tu Youyou: the legendary woman who discovered artemisinin

Footprints

Play Episode Listen Later Mar 7, 2022 15:13


​Chinese pharmacologist Tu Youyou, now 92 years old, won the 2015 Nobel Prize in Physiology or Medicine for her discovery of artemisinin, a group of drugs used to combat malaria in the 1970s. Tu once said that artemisinin, having saved millions of lives across the globe, was a gift from China to the world.

Performance Medicine Audio
Herbal Treatments For COVID-19 w/ Denise Sammons, ND

Performance Medicine Audio

Play Episode Listen Later Dec 30, 2021 26:21


In this episode of Outside The Box, we talk with Dr. Denise Sammons, Naturopathic Doctor/CEO of Sozo Life and Wellness, about the best herbal treatments for COVID-19. Some of the herbals covered in this episode: Artemisinin, Takuna, Noni, Nutrizyme, Lumbrokinase, Barberry, Serrapeptase, Mapalo, Pinela, NAC, and more! What did you think of this episode of the podcast? Let us know by leaving a review! Connect with Performance Medicine! Sign up for our weekly newsletter: https://performancemedicine.net/doctors-note-sign-up/ Facebook: @PMedicine Instagram: @PerformancemedicineTN YouTube: Performance Medicine

Dog Cancer Answers
Artemisinin for Dogs with Cancer | Dr. Nancy Reese Deep Dive

Dog Cancer Answers

Play Episode Listen Later Oct 11, 2021 21:58


In this week's episode Dr. Nancy discusses the herb artemisinin: what it is, what it has been able to do in the lab, and how to discuss adding it to your dog's treatment plan with your vet. Artemisinin has shown promise in studies as an adjunctive treatment for a variety of cancers, including bone cancer. It targets several of the hallmarks of cancer, has potential to help destroy cancer cells, and may also make cells more sensitive to chemotherapy. There is still work to be done on dosing, as artemisinin has a short half-life which can make it challenging to deliver the compound to the actual cancer cells, but we are learning more about how to give it to get the best results while minimizing side effects. Artemisinin is not a good fit for dogs who are undergoing radiation therapy or have a seizure disorder, but otherwise it is very safe. Links Mentioned in Today's Show: The Dog Cancer Survival Guide: Full Spectrum Treatments to Optimize Your Dog's Life Quality and Longevity by Dr. Demian Dressler and Dr. Susan Ettinger NIH Clinical Trials Studies on Artemisinin Related Links: Podcast episode on osteosarcoma: https://dogcanceranswers.com/osteosarcoma-what-you-need-to-know-about-your-dogs-bone-cancer/ Apoptosis: https://www.dogcancerblog.com/articles/book-excerpt/apoptosis-for-cancer-cells/ About Today's Guest, Dr. Nancy Reese: Dr. Nancy Reese is a small animal veterinarian with over 30 years of clinical experience taking care of cats and dogs and other critters in the Sierra Nevada foothills. She is also a perpetual student and researcher, as evidenced by her many degrees. In addition to her Doctor of Veterinary Medicine from the University of California, Davis, she earned a Masters in Preventive Veterinary Medicine at UC Davis and then a Ph.D. in Epidemiology at UC Davis. If you string all her letters out after her name it looks like this: Nancy Reese, DVM, MPVM, PhD. In her spare time, she volunteers to help evacuate and shelter animals caught up in disasters, and she's currently training to help in human search and rescue efforts. Dr. Reese lives in a log cabin with her husband, her 13-year-old golden retriever, and her two 13-year-old cats. Her hobbies include boosting the quality of life and longevity for all animals in her care, hiking, travelling, and cross-country skiing. Oh, and lots of dog walking.  degree from the University of California at Davis before earning his Doctorate in Veterinary Medicine from Cornell University. Other Links: To join the private Facebook group for readers of Dr. Dressler's book “The Dog Cancer Survival Guide,” go to https://www.facebook.com/groups/dogcancersupport/  Dog Cancer Answers is a Maui Media production in association with Dog Podcast Network This episode is sponsored by the best-selling animal health book The Dog Cancer Survival Guide: Full Spectrum Treatments to Optimize Your Dog's Life Quality and Longevity by Dr. Demian Dressler and Dr. Susan Ettinger. Available everywhere fine books are sold. Have a guest you think would be great for our show? Contact our producers at DogCancerAnswers.com Have an inspiring True Tail about your own dog's cancer journey you think would help other dog lovers? Share your true tail with our producers. If you would like to ask a dog cancer related question for one of our expert veterinarians to answer on a future Q&A episode, call our Listener Line at 808-868-3200 www.dogcanceransers.com. Dog Cancer News is a free weekly newsletter that contains useful information designed to help your dog with cancer. To sign up, please visit: www.dogcancernews.com

Wissenschaftsmagazin
Malariamedikamente verlieren an Wirkung

Wissenschaftsmagazin

Play Episode Listen Later Oct 2, 2021 28:19


Und: Sexuell missbrauchte Mädchen lassen sich im Internet häufiger auf gefährliche Treffen ein.Zudem: Gute Forschungsförderung fahndet nach schlauen Geistern und manchmal ist es dafür am besten auszulosen. (00:31) Malariamedikamente verlieren an Wirkung: Es ist eine beängstigende Entwicklung: Malariaparasiten in Afrika werden zunehmend resistent gegen Artemisinin basierte Wirkstoffe. Das ist besonders fatal, weil in Afrika 90% der weltweiten Malariainfektionen auftreten. (08:04) Sexuell missbrauchte Mädchen werden im Internet leicht erneut zum Opfer: Sie lassen sich häufiger auf gefährliche Treffen ein und ihr Risiko im Internet gemobbt zu werden, ist dreifach erhöht.  (14:30) Folgen der Waldbrände in Australien: Die reichen mit horrenden CO2-Emissionen und Algenblüten weit über die Brandflächen hinaus. (19:16) Geld verteilen – aber richtig: Gute Forschungsförderung fahndet nach schlauen Geistern und manchmal ist es dafür am besten, das Los zu werfen. (08:04) Meldungen: • (08:04) Sexuell missbrauchte Teenager riskieren im Internet erneute Übergriffe • (11:08) Angst vor 5G geht mit Misstrauen gegen die Behörden einher • (13:17) Bepi Colombo hat sein erstes Rendez-Vous mit dem Merkur

ZellKultur
ZK030 - mRNA-Impfungen... Aber sag nicht Corona!

ZellKultur

Play Episode Listen Later Jun 14, 2021 41:21 Transcription Available


Huch, schon wieder eine Impffolge. Diesmal soll es um die Möglichkeiten gehen, die RNA-basierte Impfstoffe eröffnen: nicht nur sehr schnell generell Impfstoffe gegen neue Krankheiten zu entwickeln, sondern auch – wenn wir schon die Möglichkeit haben - die schlimmsten schon lange existierenden Erreger loszuwerden. Einer davon ist Malaria. Das Wort “Malaria” bedeutet eigentlich “schlechte Luft”, weil man früher der Meinung war, dass die Krankheit durch Dämpfe aus Sümpfen ausgelöst wird. Tatsächlich wird diese Krankheit durch Erreger der Gattung Plasmodium hervorgerufen, welche durch Stiche der Anophelesmücke übertragen werden. Der diesjährige Word Malaria Day stand unter dem Motto “Zero Malaria – Draw the Line Against Malaria” und richtet sich vor allem an Afrika, wo über 90 % aller weltweiten Malaria-Fälle auftreten. Denn obwohl die Malaria-Fälle von 2010 bis 2019 in Afrika um 29 % zurückgingen und die Anzahl der dadurch verursachten Todesfälle um 60%, sterben jedes Jahr noch über 400.000 Menschen an dieser Krankheit und davon sind zwei Drittel Kinder unter 5 Jahren. Leider stagniert die Anti-Malaria-Kampagne seit einigen Jahren und kam durch die SARS-CoV-2-Pandemie zusätzlich ins Stocken. Auch Resistenzentwicklung beim Erreger gegen die (prophylaktischen) Medikamente und bei der Mücke gegen die Vektorinsektizide erschweren die Bekämpfung dieser Krankheit, so dass ein breit anwendbarer und einfach handhabbarer Malaria-Impfstoff noch sehnlicher als der “Corona-Impfstoff" erwartet wird. Der bisher zugelassene RTS,S(Mosquirix)-Impfstoff wird bisher vorwiegend bei Kleinkindern angewandt, ist nicht so wirksam wie erhofft und zudem äußerst aufwändig zu verabreichen. Doch wie verbreitet sich der Erreger? Durch den Stich der Anophelesmücke gelangen infektiöse Sporozoiten, also eine Art “Sporen, die dann am Zielort auskeimen” in die menschliche Blutbahn und von dort in Leberzellen (Zielort). Innerhalb der Leber entwickeln sie sich zu einer “Gewebeschizont” genannten Dauerform, die periodisch Merozoiten (“Minisporen”) ins Blut abgibt. Diese befallen rote Blutkörperchen und können sich in diesen vermehren und zu geschlechtlichen Formen, also zu etwas Vergleichbarem wie Spermien und Eizellen differenzieren. Wenn diese von einer Mücke aufgesaugt werden, vereinigen sich diese geschlechtlichen Formen zu einer Zelle, die neue Sporozoiten ausbilden kann. Natürlich können sich auch Tiere mit Malaria infizieren und taten das schon lange vor den Menschen. Mittlerweile gibt es natürlich auf den Menschen angepasste Arten von Plasmodium. Doch auch der Mensch hat sich nicht kampflos in den Infektionszyklus eingereiht, sondern im Laufe der Jahrhunderte seine eigene “Escape-Mutante" ausgebildet. Aktuell bekämpft man hauptsächlich die Überträger der Plasmodien, nämlich die Mücke aktiv. Das geht mit dem Einsatz von imprägnierten Mückennetzen und spezieller Kleidung (Expositionsprophylaxe), aber auch Insektizide tragen dazu bei. Prophylaktisch und zur Behandlung von Malaria werden auch verschiedene Medikamente eingesetzt, z.B. das via seiner Entdeckerin Youyou Tu 2015 Nobelpreis-prämierte Artemisinin. Wenn wir nicht über Malaria reden, erfreuen wir uns der Tatsache, dass spezielle RNA-Impfungen voraussichtlich auch in der Krebstherapie gesetzt werden. Auch eine Art kleine transiente Schwester der Gentherapie ließe sich mittels mRNA-Impfung realisieren. In der Bio-Frage besprechen wir, ob Menschen, die an Sichelzellanämie erkrankt sind, einen Vorteil bei Malariainfektionen haben. Wer die Antwort nicht erwarten kann oder noch einmal nachlesen will, findet hier mehr. Wenn euch die Folge gefallen hat, werft uns doch via Paypal ein paar Groschen in den Hut: paypal.me/ZellKultur Oder schreibt unserem Podcast eine Bewertung auf iTunes, Spotify oder anderen Podcastportalen. ;)

Forschung Aktuell - Deutschlandfunk
Wirkstoff Artemisinin - Resistenzen von Malaria-Erregern in Afrika befürchtet

Forschung Aktuell - Deutschlandfunk

Play Episode Listen Later Apr 26, 2021 7:40


Als der Malaria-Erreger Ende des 20. Jahrhunderts resistent gegen den Wirkstoff Chloroquin wurde, war Artemisinin die Rettung. Jetzt weisen Untersuchungen darauf hin, dass sich in Afrika auch Resistenzen gegen die darauf beruhende Standardtherapie anbahnen, erklärte der US-Mediziner Philip Rosenthal im Dlf. Philip Rosenthal im Gespräch mit Christiane Knoll www.deutschlandfunk.de, Forschung aktuell Hören bis: 19.01.2038 04:14 Direkter Link zur Audiodatei

Bible Prophecy Talk - End Times Podcast and News
BPT – A Cure For Cancer? The Metabolic Theory of Cancer and Artemisinin

Bible Prophecy Talk - End Times Podcast and News

Play Episode Listen Later Mar 30, 2021 26:05


I quickly go over some research I have been doing on the metabolic theory of cancer. I dont know all the answers, but I wanted to put this out there in case anyone out there was out of time and needed some hope. [[ This is a content summary only. Visit my website for full links, other content, and more! ]]

Revelations Radio Network
BPT – A Cure For Cancer? The Metabolic Theory of Cancer and Artemisinin

Revelations Radio Network

Play Episode Listen Later Mar 30, 2021


I quickly go over some research I have been doing on the metabolic theory of cancer. I dont know all the answers, but I wanted to put this out there in case anyone out there was out of time and needed some hope. [[ This is a content summary only. Visit my website for full links, other content, and more! ]]

Performance Medicine Audio
Q&A Episode w/ Tom Rogers, MD on PRP, Stem Cells, Quercetin, and Peptides

Performance Medicine Audio

Play Episode Listen Later Feb 20, 2021 50:41


In this Q&A episode, Dr. Rogers answers your questions! This week's questions: 1. My son just turned 13. We are experiencing mood swings, times where he is not interested in doing anything and he wants to be alone. I know some of this is common but at what point should you seek help or contact a therapist to get your teen through this period of time? Thanks! 2. Please tell us about PRP therapy and upcoming stem cell research and how this can help us. 3. What's the difference in bio-quercetin vs. regular Quercetin? Which do you prefer? If bio-quercetin has 5mg, how does that compare to the regular Quercetin at 1,000mg? 4. What's all the hype about peptides? What are they and how do they benefit you? Do you recommend taking them? 5. Thoughts on Artemisinin? Is it comparable to Hydroxychloroquine and Ivermectin? Plus a whole lot more! What did you think of this episode of the podcast? Let us know by leaving a review! Connect with Performance Medicine! Sign up for our weekly newsletter: https://performancemedicine.net/doctors-note-sign-up/ Facebook: @PMedicine Instagram: @PerformancemedicineTN YouTube: Performance Medicine Audio

Ordinarily Extraordinary - Conversations with women in STEM
Shalini Aggarwal-PhD Research Scholar, Bachelor's in Microbiology, Master's in Biotechnology

Ordinarily Extraordinary - Conversations with women in STEM

Play Episode Listen Later Jan 6, 2021 70:05


Shalini Aggarwal is a PhD research scholar studying infectious diseases at the Indian Institute of Technology in Bombay. She has a bachelor's degree in microbiology and a master's degree in biotechnology. She is passionate about studying the vivax parasite that causes malaria and its treatment and about how challenges we experience throughout our lives contribute to our future successes.Episode NotesMusic used in the podcast: Higher Up, Silverman Sound StudioAcronyms, Definitions, and Fact CheckApproximately 25% of US citizens can hold a conversation in a language other than English.  (news.gallup.com)5 parasites that cause Malaria: Plasmodium falciparum (or P. falciparum), Plasmodium malariae (or P. malariae), Plasmodium vivax (or P. vivax), Plasmodium ovale (or P. ovale), Plasmodium knowlesi (or P. knowlesi). (www.standfordhealthcare.org)Malaria occurs in more than 100 countries and territories. About half of the world's population is at risk. Large areas of Africa and South Asia and parts of Central and South America, the Caribbean, Southeast Asia, the Middle East, and Oceania are considered areas where malaria transmission occurs. (www.cdc.gov)Artemisinin and its semisynthetic derivatives are a group of drugs used against malaria due to Plasmodium falciparum. It was discovered in 1972 by Tu Youyou, who was co-recipient of the 2015 Nobel Prize in Medicine for her discovery. (wikipedia)B Tech - Bachelor's of Technology (wikipedia)Maternity leave in the United States is regulated by US labor law. The Family and Medical Leave Act of 1993 (FMLA) requires 12 weeks of unpaid leaveannually for mothers of newborn or newly adopted children if they work for a company with 50 or more employees. (wikipedia)Microbes - a microscopic organism, which may exist in its single-celled form or a colony of cells. (wikipedia)www.spharro.com

The Panacea Concept
Own Your Health Audience Summit Questions Part 2

The Panacea Concept

Play Episode Listen Later Sep 10, 2020 56:26


Name: Barbara Message: I have a 20 year old son with autism. He takes so many pills. I would like to get him off the meds. He's been on meds for autism since he was in pre school. He has had a lot of bowel /digestive problems his whole life. He was a normal baby. I'm convinced the vaccines caused the autism. How can I help him? We tried a gluten free diet, but that didn't help. Name: shirlee Message: where dose one start? I mean there is so much to change. what is the first steps on a budget. whats the most important thing to do first and where do you go from there. I have been used for a long time for medical pills test drugs About 5 years a go I started to clue into whats going on. I have been looking ever since for a way to get better. Trying to get better in Canada, but need help Hugs and Much Love Name: Ellen Message: Can Hashimoto ‘s be reversed? Does it matter if one has been on Amour Thyroid for years as to whether there can be a reversal in hypothyroidism? If reversal is possible, what are the protocols for doing so? Name: Sharon Message: What's the possibility that Covid-19 is actually caused by last year's flu vaccine that was perhaps tainted with the malaria, or malaria-like, parasite? Three of the remedies being successfully used to treat Covid-19 patients are anti-parasitic drugs: HCQ, Artemisinin and Ivermectin. HCQ and Artemisinin are used to prevent and treat malaria. Artemisinin and Ivermectin are used to prevent and treat canine heartworms. Also, what's a simple and inexpensive method to detox the body? Thank you! I'm looking forward to your seminar! Name: Rawiri Message: Where are the traditional Maori healers in this forum we have found Western ideology does not work for indigenous people. Join My Email List https://www.subscribepage.com/toxicity-quiz If you don't own your Health who does? OWN YOUR HEALTH!!! Make sure to Like, Comment and Subscribe and share it with anyone who you feel it could serve. To apply for my Integrative Health Coaching program visit rootlvlwellness.com or email me at mathew@rootlvlwellness.com. For the latest promotions from Equilibrium Nutrition click my affiliate link to support the show https://track.equilibriumnutrition.com/SHU8 --- Send in a voice message: https://anchor.fm/mathew-diaz/message

Sunday Extra - Separate stories podcast
Traditional medicine and malaria

Sunday Extra - Separate stories podcast

Play Episode Listen Later Sep 5, 2020 11:54


Modern drug research and ancient medicine intertwine in this tale of the fight against malaria. This episode first aired February 11, 2018.

Ockham's Razor - ABC RN
Traditional medicine and malaria

Ockham's Razor - ABC RN

Play Episode Listen Later Sep 5, 2020 11:54


Modern drug research and ancient medicine intertwine in this tale of the fight against malaria. This episode first aired February 11, 2018.

Ockham's Razor - ABC RN
Traditional medicine and malaria

Ockham's Razor - ABC RN

Play Episode Listen Later Sep 5, 2020 11:54


Modern drug research and ancient medicine intertwine in this tale of the fight against malaria. This episode first aired February 11, 2018.

PaperPlayer biorxiv bioinformatics
Evidence of interaction between humoral immunity and drug half-life in determining treatment outcome for artemisinin combination therapy in high transmission settings in western Kenya

PaperPlayer biorxiv bioinformatics

Play Episode Listen Later Aug 12, 2020


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.12.248724v1?rss=1 Authors: Andagalu, B., Lu, P., Onyango, I., Bergmann-Leitner, E., Wasuna, R., Odhiambo, G., Chebone-Bore, L., Ingasia, L. A., Opot, B., Cheruiyot, A., Yeda, R., Okudo, C., Okoth, R., Campo, J., Wallqvist, A., Akala, H., Ochiel, D., Ogutu, B., Chaudhury, S., Kamau, E. Abstract: The role of humoral immunity on the efficacy of artemisinin combination therapy (ACT) has not been investigated, yet naturally acquired immunity is key determinant of antimalarial therapeutic response. We conducted a therapeutic efficacy study in high transmission settings of western Kenya, which showed artesunate-mefloquine (ASMQ) and dihydroartemisinin-piperaquine (DP) were more efficacious than artemether-lumefantrine (AL). To investigate the underlying prophylactic mechanism, we compared a broad range of humoral immune responses in cohort I study participants treated with ASMQ or AL, and applied machine-learning (ML) models using immunoprofile data to analyze individual participants treatment outcome. We showed ML models could predict treatment outcome for ASMQ but no AL with high (72-92%) accuracy. Simulated PK profiling provided evidence demonstrating specific humoral immunity confers protection in the presence of sub-therapeutic residual mefloquine concentration. We concluded patient humoral immunity and partner drug interact to provide long prophylactic effect of ASMQ. Copy rights belong to original authors. Visit the link for more info

Finding Genius Podcast
Disrupting the Complicated Cycle of Malaria: Caroline Ng Discusses her Work

Finding Genius Podcast

Play Episode Listen Later Jun 29, 2020 25:35


In her research, Dr. Caroline Ng addresses how to effectively treat malaria as scientists face possible drug resistance.  She explains for listeners The cycle and stages of malaria-causing parasites and what causes common malaria symptoms, Why the asexual blood stage of the parasite is especially important in understanding how to disrupt its infection, and What signs of resistance are scientists observing and how her research hopes to solve the issue. Caroline L. Ng, Ph.D. is an assistant professor in the Department of Pathology and Microbiology at the University of Nebraska Medical Center. She specializes in the pathogenesis of Plasmodium falciparum and the genetic and molecular mechanisms underlying drug resistance. She begins by explaining the life cycle of the parasites that cause malaria. Plasmodium spp. have evolved to require two hosts in their life cycle, mosquito and animal, and she specializes in the species that use human hosts in addition to the mosquito. She explains how the parasites move from mosquito saliva and make their way to the human liver. She describes their entry into red blood cells, how they divide asexually at an exponential rate, when they evolve into different sexes, and how a debris release causes the common malaria symptoms of fever and chills. She then builds on this explanation to describe the issues facing researches in how to treat malaria as symptoms of drug resistance seem to be showing up. In particular, the parasite Plasmodium falciparum is of concern as it is the most virulent and causes the most deaths. Artemisinin is a potent drug that's short-lived that must be partnered with another drug to make sure parasites are being cleared. But scientist in Southeast Asia have seen a decrease in the ability of this drug family to clear parasites. They worry this indicates artemisinin resistance. If they can understand this, they can designs drugs that synergize or identify a pathway to build up the efficacy of this drug. Along the way, she explains mechanisms of how these drugs work and how these poorer countries that face malaria need inexpensive treatments.  To learn more, see her information on her institution's web site: www.unmc.edu/pathology/faculty/bios/Ng.html Available on Apple Podcasts: apple.co/2Os0myK

The Science Scholars Podcast
Episode 108: Tu Youyou

The Science Scholars Podcast

Play Episode Listen Later May 20, 2020 18:33


In this episode of Other Science Scholars, we discuss the life and science of Nobel Prize winner, Tu Youyou. She won the prize in 2015 for her discoveries concerning a novel therapy against treatment-resistant malaria. To find the cure for this type of malaria, her team screened thousands of herbs mentioned in ancient Chinese medical texts. Eventually, they discovered artemisinin, an extract from sweet wormwood. Artemisinin is now commonly used in combination with other drugs to treat malaria. Her discovery has been called “the most important pharmaceutical intervention in the last half-century” (Lasker Award Presentation). She was the first mainland Chinese scientist to receive a Nobel Prize and she did it without a doctorate, medical degree, or training abroad.

Spectrum | Deutsche Welle
Don't drink the (tea)

Spectrum | Deutsche Welle

Play Episode Listen Later May 19, 2020 4:58


No, an herbal beverage from Madagascar will not prevent COVID-19. But one of its molecules is intriguing. Listen to DW's science podcast for a different angle on the coronavirus — five minutes every day from Germany.

Laser 'D' Mic
Artemisinin; one of the major components of Madagascar's Covid Organic.

Laser 'D' Mic

Play Episode Listen Later May 17, 2020 3:04


Africans should not be used as guinea pigs for science. Widespread consumption of Covid Organic can render anti malaria drugs ineffective.

Witness History
The Chinese cure for malaria

Witness History

Play Episode Listen Later Mar 23, 2020 9:01


In the 1970s, scientists in China used ancient traditional medicine to find a cure for malaria. Artemisinin was discovered by exploring a herbal remedy from the 4th century, and can cure most forms of malaria with very few side effects. It has saved millions of lives all over the world. Rebecca Kesby talks to Professor Lang Linfu, one of the scientists involved. PHOTO: Professor Lang Linfu (family archives)

This Week in Parasitism
TWiP 180: A spleen palaver

This Week in Parasitism

Play Episode Listen Later Feb 8, 2020 81:57


The TWiP professors solve the case of the Ugandan Child with Splenomegaly, and reveal that mutations in the P. falciparum genome that confer artemisinin resistance interfere with endocytic uptake of hemoglobin. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode PWB social media: Facebook, Instagram, Twitter Endocytosis pathway mediates artemisinin resistance in malaria parasites (Science) Letters read on TWiP 180 Become a patron of TWiP. Case Study for TWiP 180 Uganda with a twist. Meets two people with watery diarrhea, 12 episodes/day, loss of appetite. No fever, no blood in stool. Living for months at staff guest house. One week prior to onset went on weekend trip to area with waterfalls. Were served outdoor meal: meat, salad, fruit. Recommends empiric treatment trimethoprim/sulfamethoxzole for 7 days. Prompt resolution of diarrhea. A few days later, upon drinking coffee with milk gets severe cramps. 20s, long term female volunteers.  Send your case diagnosis, questions and comments to twip@microbe.tv Music by Ronald Jenkees

Planet PhD
Bruna Abreu: Green chemistry and drug synthesis

Planet PhD

Play Episode Listen Later Jun 24, 2019 26:42


In this weeks episode we chat to Bruna Abreu from the University of Nottingham about her research in the synthesis of analogues of the antimalarial drug Artemisinin using flow chemistry techniques. Bruna obtained her bachelor degree in Chemistry at the University of São Paulo in Brazil, where she did research in the synthesis of natural products. She then did a placement at Cambridge University where she learned about flow chemistry. Listen to hear Veronica and Gigi struggle to grasp even the simplest chemical jargon, all about green chemistry and why it's so important and some pretty crazy stories which are bound to arise when you work with highly flammable chemicals...  

Quax
Ep. 16 Story Time with Artemisinin and Horny Goat Weed

Quax

Play Episode Listen Later Jun 11, 2019 30:32


We take a break from the Weight Loss Series and do story time. The discovery of an amazing Malaria drug and horny 70 year olds. Story of the Discovery of Artemisinin: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966551/ Artemisinin Mega Link: https://www.cancertreatmentsresearch.com/artemisia-annua-its-extract-artemisinin/ David Epstein Book: https://amzn.to/2WymAAV Product Links: Artemisinin: https://amzn.to/2F3Pkf9 Sweet Wormwood Extract: https://amzn.to/2F3qaxf Horny Goat Weed Capsules: https://amzn.to/2F1GNcs Horny Goat Week Powder: https://amzn.to/2WC8qUr Music by Jenny Jahlee from Live at KBOO

Witness History
China's breakthrough malaria cure

Witness History

Play Episode Listen Later Mar 13, 2019 10:02


Chinese scientists used ancient traditional medicine to find a cure for malaria in the 1970s. Artemisinin was discovered by exploring a herbal remedy from the 4th century, a small team of scientists managed to harness the medicinal properties from the Artemisa Annua plant. It can cure most forms of malaria with very few side effects and has saved millions of lives all over the world. Professor Lang Linfu was one of the scientists involved, he told Rebecca Kesby how they made the discovery in the laboratory as China's Cultural Revolution raged across the country. (Photo; Professor Lang Linfu. Family archives)

TXBiobytes from Texas Biomed
TXBioBytes from Texas Biomed Episode 20 — Fitness Tests for Parasites

TXBiobytes from Texas Biomed

Play Episode Listen Later Oct 23, 2018 20:20


Xue Li, Ph.D., Shalini Nair, and Tim Anderson, Ph.D. Malaria is worldwide scourge infecting 200 million people around the world and killing more than 400,000 of them. The parasite is carried by the Anopheles mosquito, particularly in tropical areas like Sub-Saharan Africa and Asia. Texas Biomed scientists are “particularly interested in the evolution of drug resistance,” said Scientist Tim Anderson, Ph.D., adding that it is “a recurring problem in controlling tropical diseases.” Artemisinin is a recently discovered drug that is the gold standard for treating malaria, considered instrumental in reducing the number of cases of the infectious disease over the last decade. However, more than 125 mutation variations of drug resistance have emerged in Southeast Asia. Those mutations impact the metabolism of the parasite itself – inhibiting growth rate, for instance. A recent NIH-funded study published in the journal Antimicrobial Agents and Chemotherapy by Anderson and his team looked at one particular drug resistant variant sequence (called an allele) that is outpacing the others. Anderson’s team wanted to test the idea that successful resistance alleles have fewer adverse consequences for the parasites and, thus, thrived and spread. Shalini Nair works with malaria parasites in Dr. Tim Anderson's lab. Senior Research Associate Shalini Nair, who has worked at Texas Biomed for 18 years, was a key part of this project. “I started out by figuring out how to use CRISPR-Cas9 to edit key mutations in the malaria parasite,” Nair explained. CRISPR is short for clustered regularly interspaced short palindromic repeats. It’s a system for genome editing, using the cell’s own DNA repair mechanism to add or delete pieces of genetic material. To maximize the relevance of their results, the team used “a recently isolated parasite clone from the Thailand-Myanmar border for manipulation rather than a laboratory adapted parasite clone,” the journal article stated. Malaria parasites grow in flasks of red blood cells. In a head-to-head comparison between two mutants – one strong and thriving in patients and one not as strong and waning – researchers grew the parasites in flasks of blood cells in the lab. Scientists measure how the mutations impacted the “fitness” of the parasites. In other words, they checked to see if the mutations impacted the metabolism of the more common and less common strains in the expected way. Scientists hypothesized the more common and thriving mutations would have less “fitness cost” to the parasite. The cultures were maintained for 60 days. Then they extracted DNA and amplified it, comparing frequencies of the different mutations. Xue Li, Ph.D., is a post-doctoral student who compiled the data from the study. “Our results were not the same as our hypothesis,” Li stated. The scientists want to see if there are other mutations in different areas of the genome impacting whether these drug-resistant parasites flourish or fail. The answer may be more complicated than first thought. Dr. Anderson emphasized that malaria researchers like his team need to understand the process by which parasites adapt to anti-malarials.” If we understand that,” he said, “we are in a far better position to then to develop more effective, evolution proof interventions.”  

Talking Biotech Podcast
148 – Malaria, Artemisia and Artemisinin

Talking Biotech Podcast

Play Episode Listen Later Aug 25, 2018 41:18


Malaria is a tremendous world health problem, affecting the lives of hundreds of millions of people in the developing (and industrialized) world. One of the most effective therapies is derived from a natural compound produced [...]

Translational Medicine
Finding the best malaria treatments

Translational Medicine

Play Episode Listen Later Nov 2, 2016 5:50


Dr Mehul Dhorda heads the Asia Regional Centre of the WorldWide Antimalarial Resistance Network (WWARN). Artemisinin resistance is firmly established in many parts of Southeast Asia and threatens the lives of millions of people. To improve regional intelligence and aid containment efforts, Dr Dhorda promotes the collection of high quality data on malaria drug resistance. His research aims to simplify and harmonise data, securely store results and analyse comparative or collective pooled analyses.

Malaria
Finding the best malaria treatments

Malaria

Play Episode Listen Later Nov 2, 2016 5:50


Dr Mehul Dhorda heads the Asia Regional Centre of the WorldWide Antimalarial Resistance Network (WWARN). Artemisinin resistance is firmly established in many parts of Southeast Asia and threatens the lives of millions of people. To improve regional intelligence and aid containment efforts, Dr Dhorda promotes the collection of high quality data on malaria drug resistance. His research aims to simplify and harmonise data, securely store results and analyse comparative or collective pooled analyses.

The Lancet Global Health
Artemisinin combination therapies: The Lancet Global Health, November 10, 2015

The Lancet Global Health

Play Episode Listen Later Nov 11, 2015 10:14


Job Mogire and author Maciej Boni discuss a modelling study that projects the best way to use artemisinin combination therapies at the population level.

NEWSPlus Radio
【专题】慢速英语(英音)2015-11-02

NEWSPlus Radio

Play Episode Listen Later Oct 30, 2015 25:00


This is NEWS Plus Special English. I'm Mark Griffiths in Beijing. Here is the news. The anti-malarial compound Artemisinin, discovery of which won Dr. Tu Youyou China's first Nobel Prize for Physiology or Medicine this year, has not resulted in big profits for Chinese pharmaceutical companies. Guilin Pharma Limited, affiliated to Shanghai-listed Fosun Pharma, is the only Chinese firm on the World Health Organization's list of recommended providers of the anti-malarial drug. The drug is extracted from a Chinese herb. With the exception of Guilin Pharma Limited, traditional Chinese medicine producers are still barred from sending their products to the international market because they lack certification by major international agencies of the World Health Organization, the United States and the European Union. China has 80 percent of the world's materials for extracting Artemisinin. However, most traditional medicine producers can only sell the raw materials to foreign companies for marginal profits. Their own Artemisinin-containing products may not directly enter the global market. Guilin Pharma Limited has sold 24 million doses of Artemisinin to the global market over the past three years, benefitting 3 million people, with 90 percent in Africa. This is NEWS Plus Special English. The vice chancellor of the University of Oxford Ralph Waller says the heart of education is friendship. Waller made the remarks in Beijing during his visit to introduce a new program to identify experienced talents in the Asia-Pacific region as potential visiting scholars. The program is open to any senior personnel in education and business, as well as entrepreneurs. Ralph told journalists that professors and students are both on the same side. Professors are not constantly assessing the students, or vice versa. They work together. He said a good university needs good professors to attract good students; and friendship between the professors and the students makes a big difference. Oxford has 38 different colleges. The largest number of overseas students at Oxford comes from America, followed by China. Chinese President Xi Jinping acknowledged the education exchanges between the two countries during his recent visit to Britain. Ralph said education is not just about reading, writing and thinking. It is about making friends and sparkling ideas. (全文请浏览微信周六第三条。)

This Week in Parasitism
TWiP 97: The seven year itch

This Week in Parasitism

Play Episode Listen Later Oct 16, 2015 86:57


The paratenic hosts reveal a case of scabies in the Traveling Salesman, and discuss a role for natural antibody in protection from infection with Plasmodium. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin   Links for this episode: Parasite Nobel Prizes 2015 Ivermectin story (Nat Rev Micro) Ivermectin target (Brain Res) Gut microbiota and Plasmodium protection (Cell) Natural antibody (virology blog) Image credit Letters read on TWiP 97 Case study for TWiP 97 Daniel has two cases this week. Two people with similar presentations. A 12 yo girl in Peru presented for care with painless dark brown area on right knee. Has brothers and sisters, often play together. No trauma, but area is expanding. Months later develops cognitive changes. Second case is a 5 yo boy from the coastal region of Peru brought in by Mother, has red swollen area on face. Mom says while playing scratched nose, swelling right cheek, eye, nasal obstruction, no response to antibiotics. MRI of both show infiltrating process. Girl, left side of brain, middle cerebral artery territory. Boy in frontal region, midline area. Thus both skin lesions associated with infiltrating process in brain. Came into clinic months after lesions started, and lesions still present. Send your diagnosis to twip@twiv.tv Contact Send your questions and comments (email or mp3 file) to twip@twiv.tv Subscribe Subscribe to TWiP (free) in iTunes, by the RSS feed or by email  

NEWSPlus Radio
【专题】慢速英语(美音)2015-10-13

NEWSPlus Radio

Play Episode Listen Later Oct 10, 2015 25:00


全文请参阅微信周日第三条。Traditional Chinese medicine has won more recognition in Western countries in recent years, but the 5,000-year-old medical science still needs a modern interpretation to break into the mainstream Western market. According to the Beijing-based World Federation of Chinese Medicine Societies, more Traditional Chinese Medicine clinics have opened in Western countries and more colleges are starting to offer Traditional Chinese Medicine education, but it has not attained legal status in many countries. In some parts of the world, Traditional Chinese Medicine is considered a food supplement rather than having medicinal effects. Experts say a major reason that Traditional Chinese Medicine is not widely acknowledged is a lack of research on its pharmaceutical details and its interaction with other medicines. The number of registered Traditional Chinese Medicine practitioners worldwide is estimated at around 500,000. This is NEWS Plus Special English. Chinese scientist Tu Youyou's winning of the 2015 Nobel Prize in Medicine has drawn much attention in Italy, especially for the role traditional Chinese medicine played in helping her find a cure for malaria. Eighty-five-year-old Tu is the first Chinese woman to win the Nobel Prize in science. She was awarded together with two other scientists for developing therapies against malaria and infections caused by roundworm parasites. More specifically, the Chinese pharmacologist was recognized for discovering Artemisinin, a drug that has significantly reduced the mortality rates among people suffering from malaria. Chinese Premier Li Keqiang congratulated the scientist for her success, which "marked a great contribution of traditional Chinese Medicine to the cause of human health". Italy's main science magazine Focus has dedicated an in-depth report to the incredible story of the Chinese researcher, saying that she started from traditional medicine, and found a way to eradicate the malaria parasite at the early stage of its development. You're listening to NEWS Plus Special English. I'm Liu Yan in Beijing.

Global Health
The economics of tropical diseases

Global Health

Play Episode Listen Later Jul 28, 2015 5:23


Economics and health are interlinked in many ways, as seen in the vicious cycle between poverty and ill health. Dr Yoel Lubell leads the economic team at the MORU Mathematical and Economic Modelling Group, based in Bangkok, Thailand. His research focuses on the evaluation of diagnostics, treatments and vaccines for infectious diseases, with the aim of providing guidance on malaria elimination and control of artemisinin resistance in the Mekong region.

Translational Medicine
The economics of tropical diseases

Translational Medicine

Play Episode Listen Later Jul 28, 2015 5:23


Economics and health are interlinked in many ways, as seen in the vicious cycle between poverty and ill health. Dr Yoel Lubell leads the economic team at the MORU Mathematical and Economic Modelling Group, based in Bangkok, Thailand. His research focuses on the evaluation of diagnostics, treatments and vaccines for infectious diseases, with the aim of providing guidance on malaria elimination and control of artemisinin resistance in the Mekong region.

Global Health
The economics of tropical diseases

Global Health

Play Episode Listen Later Jul 28, 2015 5:23


Economics and health are interlinked in many ways, as seen in the vicious cycle between poverty and ill health. Dr Yoel Lubell leads the economic team at the MORU Mathematical and Economic Modelling Group, based in Bangkok, Thailand. His research focuses on the evaluation of diagnostics, treatments and vaccines for infectious diseases, with the aim of providing guidance on malaria elimination and control of artemisinin resistance in the Mekong region.

Translational Medicine
The economics of tropical diseases

Translational Medicine

Play Episode Listen Later Jul 28, 2015 5:23


Economics and health are interlinked in many ways, as seen in the vicious cycle between poverty and ill health. Dr Yoel Lubell leads the economic team at the MORU Mathematical and Economic Modelling Group, based in Bangkok, Thailand. His research focuses on the evaluation of diagnostics, treatments and vaccines for infectious diseases, with the aim of providing guidance on malaria elimination and control of artemisinin resistance in the Mekong region.

NDM International Activities
The treatment of severe malaria

NDM International Activities

Play Episode Listen Later Dec 16, 2014 8:08


Professor Arjen Dondorp tells us about his work on severe malaria and the development of new therapies. Current malaria therapies using artesunate aim to kill malaria parasites before they mature. Such medications have high success rates but need to be developed further. Based in Bangkok, Thailand, Professor Arjen Dondorp works on the pathophysiology and treatments of severe malaria, antimalarial drug resistance, and improvements in intensive care practice within developing countries.

NDM International Activities
Artemisinin therapy for malaria

NDM International Activities

Play Episode Listen Later Dec 16, 2014 5:32


Professor Nick White talks about the future of artemisinin and other drug therapies for malaria. Malaria kills more than half a million people every year. Following a number of groundbreaking clinical trials, Professor Nick White and his Thailand team successfully demonstrated the effectiveness of artemisinin drug therapy for malaria in adults, children and infants. He also pioneered artemisinin combination therapy, the first-line treatment for malaria worldwide.

Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 15/19
Modeling response and delayance to parasite clearance time to artemisinin combination therapies(ACT)

Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 15/19

Play Episode Listen Later Sep 16, 2013


Mon, 16 Sep 2013 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/16821/ https://edoc.ub.uni-muenchen.de/16821/1/Nji_Akindeh_Mbuh.pdf Nji, Akindeh Mbuh ddc:610,

The Lancet Infectious Diseases
The Lancet Infectious Diseases: September 13, 2013

The Lancet Infectious Diseases

Play Episode Listen Later Sep 13, 2013 9:49


Didier Menard discusses an assay which can identify artemisinin resistance in plasmodium falciparum malaria.

Translational Medicine
Artemisinin therapy for malaria by Professor Nick White

Translational Medicine

Play Episode Listen Later Jun 18, 2013 5:32


Professor Nick White talks about the future of artemisinin and other drug therapies for malaria. Malaria kills more than half a million people every year. Following a number of groundbreaking clinical trials, Professor Nick White and his Thailand team successfully demonstrated the effectiveness of artemisinin drug therapy for malaria in adults, children and infants. He also pioneered artemisinin combination therapy, the first-line treatment for malaria worldwide.

Translational Medicine
Artemisinin therapy for malaria by Professor Nick White

Translational Medicine

Play Episode Listen Later Jun 18, 2013 5:32


Professor Nick White talks about the future of artemisinin and other drug therapies for malaria. Malaria kills more than half a million people every year. Following a number of groundbreaking clinical trials, Professor Nick White and his Thailand team successfully demonstrated the effectiveness of artemisinin drug therapy for malaria in adults, children and infants. He also pioneered artemisinin combination therapy, the first-line treatment for malaria worldwide.

Malaria
Artemisinin therapy for malaria by Professor Nick White

Malaria

Play Episode Listen Later Jun 18, 2013 5:32


Professor Nick White talks about the future of artemisinin and other drug therapies for malaria. Malaria kills more than half a million people every year. Following a number of groundbreaking clinical trials, Professor Nick White and his Thailand team successfully demonstrated the effectiveness of artemisinin drug therapy for malaria in adults, children and infants. He also pioneered artemisinin combination therapy, the first-line treatment for malaria worldwide.

Malaria
Artemisinin therapy for malaria by Professor Nick White

Malaria

Play Episode Listen Later Jun 18, 2013 5:32


Professor Nick White talks about the future of artemisinin and other drug therapies for malaria. Malaria kills more than half a million people every year. Following a number of groundbreaking clinical trials, Professor Nick White and his Thailand team successfully demonstrated the effectiveness of artemisinin drug therapy for malaria in adults, children and infants. He also pioneered artemisinin combination therapy, the first-line treatment for malaria worldwide.

Chemistry in its element
Artemisinin: Chemistry in its element

Chemistry in its element

Play Episode Listen Later Sep 19, 2012 8:14


Artemisinin podcast from Chemistry World - the magazine of the Royal Society of Chemistry

Malaria
The treatment of severe malaria

Malaria

Play Episode Listen Later Feb 21, 2012 8:08


Professor Arjen Dondorp tells us about his work on severe malaria and the development of new therapies. Current malaria therapies using artesunate aim to kill malaria parasites before they mature. Such medications have high success rates but need to be developed further. Based in Bangkok, Thailand, Professor Arjen Dondorp works on the pathophysiology and treatments of severe malaria, antimalarial drug resistance, and improvements in intensive care practice within developing countries.

Malaria
The treatment of severe malaria

Malaria

Play Episode Listen Later Feb 21, 2012 8:08


Professor Arjen Dondorp tells us about his work on severe malaria and the development of new therapies. Current malaria therapies using artesunate aim to kill malaria parasites before they mature. Such medications have high success rates but need to be developed further. Based in Bangkok, Thailand, Professor Arjen Dondorp works on the pathophysiology and treatments of severe malaria, antimalarial drug resistance, and improvements in intensive care practice within developing countries.

This Week in Parasitism
TWiP 35: Malaria control with David Fidock

This Week in Parasitism

Play Episode Listen Later Jan 12, 2012 76:49


Vincent and Dickson discuss control of malaria with their Columbia University colleague David Fidock.

Botanic Garden
The Artemisinin Supply for Malaria Control

Botanic Garden

Play Episode Listen Later Dec 21, 2010 60:14


Part of the Healing Power of Plants lecture series given at the Botanic Gardens. Dianna Bowles OBE from the Centre for Novel Agricultural Products in York has led pioneering work on the development of new higher yielding varieties of Artemisia annua which can be grown in developing countries to provide a supply of artemisinin for use in essential malaria medications.

London School of Hygiene and Tropical Medicine Audio News - LSHTM Podcast
"ACT Consortium" Pools Top Multinational Brains To Implement Artemisinin Combinations In Malaria

London School of Hygiene and Tropical Medicine Audio News - LSHTM Podcast

Play Episode Listen Later Nov 18, 2009 6:43


Ugandan Health Ministry Commissioner Dr Anthony Mbonye and London School of Hygiene and Tropical Medicine scientist Professor David Schellenberg are just two of the multinational members of the recently-formed ACT consortium set up to pool the expertise of leading scientists and public health movers and shakers in both the developed and developing world to fight malaria with optimal use of the best drugs: artemisinin combination treatments, or ACTs. After a symposium devoted to the work of the new consortium—held at the Multilateral Initiative on Malaria Pan African Malaria Conference held in Nairobi—they talked about their current programme and the goals in sight.

London School of Hygiene and Tropical Medicine Audio News - LSHTM Podcast
Consortium To Optimise World Use Of Artemisinin Combination Treatments For Malaria

London School of Hygiene and Tropical Medicine Audio News - LSHTM Podcast

Play Episode Listen Later Nov 18, 2009 2:39


London School of Hygiene and Tropical Medicine Audio News: Consortium To Optimise World Use Of Artemisinin Combination Treatments For Malaria During the 5th Multilateral Initiative On Malaria Pan African Malaria Conference held in Nairobi, Kenya, Bianca D'Souza, Manager of the "ACT Consortium", explained to Peter Goodwin how this newly formed international group of experts is working to help make sure the WHO-recommended artemisinin combination treatments (ACTs) for malaria are reaching the people who need them, and that problems associated with their distribution, quality and availability are addressed.

The Lancet
The Lancet: July 24, 2009

The Lancet

Play Episode Listen Later Jul 24, 2009 11:02


July 24: experts review the International AIDS Society meeting.

The Lancet
The Lancet: July 24, 2009

The Lancet

Play Episode Listen Later Jul 24, 2009 15:26


Discussion of the malaria Special Report, and news from the International AIDS Society meeting in South Africa.

The Lancet Infectious Diseases
The Lancet Infectious Diseases: April 25, 2008

The Lancet Infectious Diseases

Play Episode Listen Later Apr 25, 2008 15:17


'The pieces are increasingly in place to achieve the Secretary General's vision for universal coverage and make rapid gains toward ending malaria deaths in Africa. With one child dying every 30 seconds from malaria in Africa, we have not a moment to lose'. In a joint podcast between The Lancet and The Lancet Infectious Diseases, Sally Hargreaves assesses renewed efforts to scale up prevention and treatment of malaria, coinciding with World Malaria Day on April 25.

The Lancet
The Lancet: April 25, 2008

The Lancet

Play Episode Listen Later Apr 25, 2008 15:19


'The pieces are increasingly in place to achieve the Secretary General's vision for universal coverage and make rapid gains toward ending malaria deaths in Africa. With one child dying every 30 seconds from malaria in Africa, we have not a moment to lose'. In a joint podcast between The Lancet and The Lancet Infectious Diseases, Sally Hargreaves assesses renewed efforts to scale up prevention and treatment of malaria, coinciding with World Malaria Day on April 25.