Podcasts about Spectrometry

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Best podcasts about Spectrometry

Latest podcast episodes about Spectrometry

Crazy Wisdom
Episode #422: Mining the Stars: The Future of Resources with Matthew Gialich

Crazy Wisdom

Play Episode Listen Later Dec 30, 2024 53:51


On this episode of the Crazy Wisdom Podcast, host Stewart Alsop chats with Matthew Gialich, co-founder and CEO of AstroForge, about the fascinating world of asteroid mining. They explore how advances in technology and reduced launch costs are enabling humanity to tap into the untapped resources of metallic asteroids, the challenges of deep space operations, and the long-term vision for making asteroid mining economically viable. Listeners can follow AstroForge for updates on LinkedIn and Twitter, and connect with Matthew directly for inquiries on his LinkedIn or at matt@astroforge.io.Check out this GPT we trained on the conversation!Timestamps00:00 Introduction to the Crazy Wisdom Podcast00:17 Asteroid Mining: Current Knowledge and Discoveries01:58 Near-Earth Asteroids and Their Potential04:08 The Value of Platinum Group Metals06:21 Spacecraft Operations and Human Involvement11:06 Asteroid Missions and Scientific Discoveries21:38 Economic and Environmental Implications of Space Mining27:04 Collaborating with SpaceX for Asteroid Missions27:42 Challenges and Opportunities in Moon Mining29:20 Navigating Gravity in Space Missions30:09 The Origin Story of Astroforge33:32 Asteroid Mining: Past and Present34:29 The Future of Space Industry and Business38:05 Radiation Challenges in Deep Space40:44 Thermal Management in Spacecraft42:43 Innovations in Robotics and Manufacturing45:37 The Role of Software in Space Startups50:10 Recruiting Top Talent for Astroforge51:37 Knowledge Management and Team Structure52:40 Staying Connected with AstroforgeKey InsightsAsteroid Mining is Becoming Feasible: Advancements in telescope technology and reduced launch costs are paving the way for asteroid mining to transition from science fiction to reality. AstroForge is focused on mining metallic asteroids rich in platinum group metals, which are critical for various industrial applications.Near-Earth Asteroids Offer Better Opportunities: Contrary to Hollywood depictions of mining in the asteroid belt, near-Earth asteroids are more accessible and practical targets for mining. These asteroids are closer to Earth and contain valuable materials, making them ideal for the initial stages of space resource exploitation.The Importance of Platinum Group Metals: Platinum, rhodium, palladium, and other platinum group metals are integral to modern technology, found in everything from electronics to industrial equipment. Mining these materials in space could revolutionize supply chains and reduce the environmental impact of terrestrial mining.The Role of Technology in Exploration: AstroForge uses cutting-edge sensors, spectrometry, and imaging systems to study and identify the best asteroids for mining. These technologies allow for remote analysis of asteroid composition, paving the way for efficient resource extraction missions.Spacecraft Design for Deep Space: AstroForge is designing spacecraft optimized for deep space exploration, which operate in the harsh conditions beyond Earth's gravity well. Challenges like radiation, thermal management, and propulsion systems are central to the company's engineering efforts.Economic and Environmental Impacts of Space Mining: Space mining has the potential to make terrestrial mining for certain materials economically obsolete, reducing environmental damage and the hazardous conditions associated with deep-earth mining operations. The company's vision includes making Earth a better place by shifting resource extraction to space.The Evolution of the Space Industry: The space sector is evolving rapidly, with private companies leading the charge in areas traditionally dominated by government agencies. AstroForge's mission is a testament to this shift, focusing on commercializing deep space exploration and mining with innovative strategies and cost-efficient technologies.

Chasing Consciousness
ANALYSING UFO EXPERIENCER'S BRAINS & ANOMALOUS MATERIALS - Garry Nolan PHD #62

Chasing Consciousness

Play Episode Listen Later Aug 31, 2024 88:04


Is the brain structure found in many UFO experiencers and remote viewers related to intuition? Are anomalous isotope ratio alloys, allegedly fallen from UFO's, evidence that can help important jumps in the research into energy and transportation technologies? How can this be both a physical and psychological phenomenon simultaneously? Is there a connection between the mind and this brain structure and the phenomena? In this episode, we take a stab at talking scientifically about the fascinating, empirically problematic and historically controversial UFO phenomenon; it's particularly fascinating these days since the US director of National Intelligence confirmed in an official 2021 report that UAPs were in fact real and a ‘population of objects'. Many scientists and engineers are excited, because the study of UFO's, regardless of their origin, could give us clues to clean energy and transportation technology that we so urgently need to combat our pollution footprint, and in fact several patents have been granted to explore such experimental physics if sadly for military purposes, but at least its a start. Apart from a short comment from Harvard Astronomer and director of The Galileo project, Avi Loeb in Episode #45; and a mythological evaluation from religious studies professor Diana Pasulka in episode #53; An idealism perspective from Bernardo Kastrup in episode #34, our guest today is the first on the show to speak in detail about the scientific study of this phenomena. This episode is the perfect deeper dive into this topic, as my guest is going to speak about two pieces of physical evidence which he has studied, so often absent in claims about this phenomenon; Firstly, MRI scans and blood samples of experiencers from the military and intelligence services who had alleged interactions with UFO's; and secondly anomalous fragments of alloys recovered from alleged UFO encounter sites. Being a science podcast the data of physical evidence is always our first port of call, but as so often when discussing anomalous phenomena that don't fit with our current world view, the interpretations of that data are various and contradictory. Today's guest is the perfect person to present this data as he was contacted by US intelligence because he invented the equipment needed to analyse it; he's not shy of the possible implications of the data, while equally in no hurry to jump to any conclusions till we have confirming proof. He is the cell biologist & Chair of the Department of Pathology and part of the cancer immunology department at Stanford University school of medicine, Dr. Garry P. Nolan. He's published over 330 academic papers, holds 50 patents and has founded 8 bio-tech companies. What we discussed: 00:00 Intro. 10:00 Garry's background in genetics and immunology. 18:30 Thomas Kuhn: ‘The structure of scientific revolutions'. 24:00 Imagination and problem solving. 32:00 The brains of 15 military experiencers. 34:00 Havana Syndrome. 37:00 They shared an until-now undiscovered structure in the brain. 38:30 ‘Intuition centre' hypothesis - Basal Ganglia. 42:15 Family members also share this unlikely brain feature. 53:00 The Antenna hypothesis. 01:00:00 It's physical AND psychological. 01:09:00 Spectrometry to analyse UFO molten metal sample alloys. 01:16:50 Patents to develop new technology and energy sources. References: “Stanford Professor Garry Nolan Is Analyzing Anomalous Materials From UFO Crashes” Vice Magazine Article, Dec '21 Thomas Kuhn ,‘The Structure of Scientific Revolutions'.All-domain Anomaly Resolution Office (AARO)‘Subcortical Brain Morphometry Differences between Adults with Autism Spectrum Disorder and Schizophrenia' Paper Dr. Salvatore Cezar Pais - US Navy “UFO” fusion energy patents Interview on T.O.E. podcast Forbes article

Spectrum | Deutsche Welle
Weekly roundup — Back to school

Spectrum | Deutsche Welle

Play Episode Listen Later Aug 27, 2023 30:00


It is possible to 'download' a song clip directly from human brains — and that's good news for 'brain-to-speech' technologies of the future. Also, SU listeners (and others) have weighed in on the debate about intimate cosmetic surgery.

Astro arXiv | all categories
Asteroid Taxonomy from Cluster Analysis of Spectrometry and Albedo

Astro arXiv | all categories

Play Episode Listen Later Sep 20, 2022 1:05


Asteroid Taxonomy from Cluster Analysis of Spectrometry and Albedo by Max Mahlke et al. on Tuesday 20 September The classification of the minor bodies of the Solar System based on observables has been continuously developed and iterated over the past 40 years. While prior iterations followed either the availability of large observational campaigns or new instrumental capabilities opening new observational dimensions, we see the opportunity to improve primarily upon the established methodology. We developed an iteration of the asteroid taxonomy which allows the classification of partial and complete observations (i.e. visible, near-infrared, and visible-near-infrared spectrometry) and which reintroduces the visual albedo into the classification observables. The resulting class assignments are given probabilistically, enabling the uncertainty of a classification to be quantified. We built the taxonomy based on 2983 observations of 2125 individual asteroids, representing an almost tenfold increase of sample size compared with the previous taxonomy. The asteroid classes are identified in a lower-dimensional representation of the observations using a mixture of common factor analysers model. We identify 17 classes split into the three complexes C, M, and S, including the new Z-class for extremely-red objects in the main belt. The visual albedo information resolves the spectral degeneracy of the X-complex and establishes the P-class as part of the C-complex. We present a classification tool which computes probabilistic class assignments within this taxonomic scheme from asteroid observations. The taxonomic classifications of 6038 observations of 4526 individual asteroids are published. The ability to classify partial observations and the reintroduction of the visual albedo provide a taxonomy which is well suited for the current and future datasets of asteroid observations, in particular provided by the Gaia, MITHNEOS, NEO Surveyor, and SPHEREx surveys. arXiv: http://arxiv.org/abs/http://arxiv.org/abs/2203.11229v2

Astro arXiv | astro-ph.EP
Asteroid Taxonomy from Cluster Analysis of Spectrometry and Albedo

Astro arXiv | astro-ph.EP

Play Episode Listen Later Sep 20, 2022 1:05


Asteroid Taxonomy from Cluster Analysis of Spectrometry and Albedo by Max Mahlke et al. on Tuesday 20 September The classification of the minor bodies of the Solar System based on observables has been continuously developed and iterated over the past 40 years. While prior iterations followed either the availability of large observational campaigns or new instrumental capabilities opening new observational dimensions, we see the opportunity to improve primarily upon the established methodology. We developed an iteration of the asteroid taxonomy which allows the classification of partial and complete observations (i.e. visible, near-infrared, and visible-near-infrared spectrometry) and which reintroduces the visual albedo into the classification observables. The resulting class assignments are given probabilistically, enabling the uncertainty of a classification to be quantified. We built the taxonomy based on 2983 observations of 2125 individual asteroids, representing an almost tenfold increase of sample size compared with the previous taxonomy. The asteroid classes are identified in a lower-dimensional representation of the observations using a mixture of common factor analysers model. We identify 17 classes split into the three complexes C, M, and S, including the new Z-class for extremely-red objects in the main belt. The visual albedo information resolves the spectral degeneracy of the X-complex and establishes the P-class as part of the C-complex. We present a classification tool which computes probabilistic class assignments within this taxonomic scheme from asteroid observations. The taxonomic classifications of 6038 observations of 4526 individual asteroids are published. The ability to classify partial observations and the reintroduction of the visual albedo provide a taxonomy which is well suited for the current and future datasets of asteroid observations, in particular provided by the Gaia, MITHNEOS, NEO Surveyor, and SPHEREx surveys. arXiv: http://arxiv.org/abs/http://arxiv.org/abs/2203.11229v2

Bringing Chemistry to Life
The chemistry of outer space

Bringing Chemistry to Life

Play Episode Listen Later Jul 14, 2021 30:09


Visit https://thermofisher.com/bctl to register for your free Bringing Chemistry to Life T-shirt and https://www.alfa.com/en/chemistry-podcasts/ to access our episode summary sheet, which contains links to recent publications and additional content recommendations for our guest.The only chemistry we know is what we can experience on our planet, or is it? Brett McGuire is among the pioneers looking beyond the Earth's atmosphere and discovering a surprising and fascinatingly complex chemical world that defies imagination and provides intriguing new insights into the origin of the chemistry we know. In one of our most fascinating episodes yet, Paolo and Brett discuss astrochemistry, the study of chemistry in outer space. Chemistry in space is unique because it is atmosphere and solvation free, and temperature is really low. By scanning radio telescope spectra, astrochemists are discovering hundreds of complex organic molecules in the spaces between stars and are developing intriguing new theories on the origin of our chemical reservoir, the reasons for biological L- chirality, and how life could vary in different parts of the universe. If you're tempted to dismiss this as mere curiosity, you will be surprised by how efforts to study chemistry happening light years away from our planet are often the key to revolutionizing chemistry here on Earth.

Divergent Mind: Insanity and Innovation.
Season 2: EP 38: Things I'm getting done by the end of the day: The Things List. January 14th-16th, 2020. Divergent Mind Podcast.

Divergent Mind: Insanity and Innovation.

Play Episode Listen Later Jan 18, 2021 12:22


Collective neuron firing to get lateral and longitudinal movement of outside materials. They would be a reverse optic nerve feedback system. You would think of the image, pull it to the glasses inner display and it would then be interpolated from that devices control output system to the meshed outer devices and they would align magnetically with timed rotations, leans, and magnetic cycles to get the resulting physical build you would want. Outer device: 360 degrees of leaned and straight rotation in each arm, simple levers with electromagnets in each tip that can bee flipped from on state to the next. In the center housing. Code Matrix for all possible movements. Cycles for all magnetic field interactions as well as leans, and rotations, and their combinations. Make them taught by learners until a suitable neural network is combined and working. Program each item with its own identity. Power: too big and heavy. Must think of an atom generator again. Communication to eye wear. RF, or bt. You could present the glasses information by scanning the cones and rods of the users eyes and overlaying the image into the viewing surface so they ”thought” of the image subconsciously and then they would internally visualize the material causing specific movements of cones and rods as they read the item and build the item through glasses instruction. So if each atom has spin both forward and back in time ie that time crystals can be made to repeat in time then there must be a way to gain access to an organ and then do the same for their atoms. Spectrometry to see through tissue Cross action wave lengths to hold and repeat atoms up to cells up to organs chained in time forward and back continuously with continuous propagation of the wave cycle. Status of cells over time extended vastly until malfunction or outside actions remove function. Patch's on the organs can be attached medically to donor organs to power through cellular electric jolts regulated safely to the living tissues differences. Powered by discrete units of body heat with maximums built in to avoid over voting the tissue matrices. Or fluid dynamics could do the same. Or a combination of the two may be the result with known cycle cell data. Once the body accepts the new organ, it immediately begins working to fit in with adjusted spectrometry wave propagation to allow seamless joins. I think it may be a matter of donor cells attaching enough to users cells to scar over and seal shut safely. That can be quickened if the cell materials of both donor and donee are figured out beforehand and mapped with a computer simulation for bodily welds. Then healing cells should come along and do their job cycling through. Patch would have to cycle current cells, know when it's attaining new cells so it knows to shed old cells so cancers don't grow. That is also a matter of cellular matrices. First need that cell data to get visible units deferred. Then inspect under proper system to attain atom varieties within the user. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/divergentmind/message Support this podcast: https://anchor.fm/divergentmind/support

PaperPlayer biorxiv biochemistry
First 3D-Structural Data of Full-length Rod-Outer-Segment Guanylyl Cyclase 1 in Bovine Retina by Cross-linkingMass Spectrometry

PaperPlayer biorxiv biochemistry

Play Episode Listen Later Sep 25, 2020


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.25.312835v1?rss=1 Authors: Rehkamp, A., Taenzler, D., Tueting, C., Kastritis, P. L., Ihling, C. H., Kipping, M., Koch, K.-W., Sinz, A. Abstract: The rod-outer-segment guanylyl cyclase 1 (ROS-GC1) is a key transmembrane protein for retinal phototransduction. Mutations of ROS-GC1 correlate with different retinal diseases that often lead to blindness. No structural data are available for ROS-GC1 so far. We performed a 3D-structural analysis of native ROS-GC1 from bovine retina by cross-linking/mass spectrometry (XL-MS) and computational modeling. Absolute quantification and activity measurements of native ROS-GC1 were performed by MS-based assays directly in bovine retina samples. Our data present the first 3D-structural analysis of active, full-length ROS-GC1 in bovine retina. We propose a novel domain organization for the intracellular domain ROS-GC1. Our XL-MS data reveal that the -helical domain connecting the kinase homology and catalytic domains can acquire different conformations. Also, the XL-MS data of native ROS-GC1 in bovine retina agree with a dimeric architecture. Our integrated approach can serve as a blueprint for conducting 3D-structural studies of membrane proteins in their native environment. Copy rights belong to original authors. Visit the link for more info

PaperPlayer biorxiv bioinformatics
Sequence-specific model for predicting peptide collision cross-section values in proteomic ion mobility spectrometry

PaperPlayer biorxiv bioinformatics

Play Episode Listen Later Sep 15, 2020


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.14.296590v1?rss=1 Authors: Chang, C.-H., Yeung, D., Spicer, V., Krokhin, O. V., Ishihama, Y. Abstract: The contribution of peptide amino-acid sequence to collision cross-section values (CCS) has been investigated using a dataset of ~134,000 peptides of four different charge states (1+ to 4+). The migration data was acquired using a two-dimensional LC/trapped ion mobility spectrometry/quadrupole/time-of-flight MS analysis of HeLa cell digests created using 7 different proteases and was converted to CCS values. Following the previously reported modeling approaches using intrinsic size parameters (ISP), we extended this methodology to encode the position of individual residues within a peptide sequence. A generalized prediction model was built by dividing the dataset into 8 groups (four charges for both tryptic/non-tryptic peptides). Position dependent ISPs were independently optimized for the eight subsets of peptides, resulting in prediction accuracy of ~0.981 for the entire population of peptides. We find that ion mobility is strongly affected by the peptide's ability to solvate the positively charged sites. Internal positioning of polar residues and proline leads to decreased CCS values as they improve charge solvation; conversely, this ability decreases with increasing peptide charge due to electrostatic repulsion. Furthermore, higher helical propensity and peptide hydrophobicity result in preferential formation of extended structures with higher than predicted CCS values. Finally, acidic/basic residues exhibit position dependent ISP behaviour consistent with electrostatic interaction with the peptide macro-dipole, which affects the peptide helicity. Copy rights belong to original authors. Visit the link for more info

Expert Dojo
#160 Lieza D. of LiVeritas - From the Philippines to running a successful mass spectrometer startup

Expert Dojo "The Art of Startup War"

Play Episode Listen Later Aug 11, 2020 46:28


Tune into this week’s episode to hear Brian speak with Lieza Danan of Liveritas Biosciences! -A few quick words from LiVeritas: LiVeritas Biosciences unleashes the power of Mass Spectrometry with industry intelligence to advance high-quality drug candidates for our partners to deliver the most optimal clinical outcome for patients. Other mass spectrometry-based startups are grounded in academic theory and academia-developed processes.  At LiVeritas Biosciences, we leverage over 70 years of combined biopharma industry-developed processes, biotech startup lean execution-focused mindset, and clinical diagnostics experience codified into our analytical testing and our SaaS offerings to ensure production of streamlined, high-quality results directly impacting the lives of patients in the clinic.  We are grounded in industry standards as it represents reality. Our collective work improved and saved the real lives of patients in the clinic. Hear about why this company is breaking barriers and the real story behind it all! For more info, please visit https://liveritas.bio/ If you have the next big idea, apply to the Expert Dojo Accelerator: www.expertdojo.com

Revise - A Level Chemistry Revision
Foundations of Chemistry: Mass Spectrometry

Revise - A Level Chemistry Revision

Play Episode Listen Later Jan 28, 2020 9:10


Spectrometry being a pain in the mass? Jono breaks down the fundamentals of mass spectrometry for your A Level chemistry exam. In this episode, he will look at how mass spectrometry works and how the results are analysed. Ideal for preparing you for your A Level Chemistry exam. Click here for the full course, or visit this link: http://bit.ly/2uB5J8x

This Week in Virology
TWiV 575: Endless giant virus forms most beautiful

This Week in Virology

Play Episode Listen Later Nov 24, 2019 120:31


From the Fourth Symposium on Giant Virus Biology in Germany, Vincent, Rich, and Nels speak with Assaf, Stephen, and Alexandra about their careers and their work on giant viruses that infect ocean hosts: Emiliana huxleyi, Aureococcus anophagefferans, and a choanoflagellate. Hosts: Vincent Racaniello, Rich Condit, and Nels Elde Guests: Assaf Vardi, Stephen Wilhelm, and Alexandra Worden Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode 4th Ringberg Symposium on Giant Virus Biology In-plaque mass spectrometry imaging (Nature Micro) Infection by brown tide virus, AaV (Front Micro) Choano virus with a rhodopsin photosystem (PNAS) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

This Week in Virology
TWiV 575: Endless giant virus forms most beautiful

This Week in Virology

Play Episode Listen Later Nov 24, 2019 120:31


From the Fourth Symposium on Giant Virus Biology in Germany, Vincent, Rich, and Nels speak with Assaf, Stephen, and Alexandra about their careers and their work on giant viruses that infect ocean hosts: Emiliana huxleyi, Aureococcus anophagefferans, and a choanoflagellate. Hosts: Vincent Racaniello, Rich Condit, and Nels Elde Guests: Assaf Vardi, Stephen Wilhelm, and Alexandra Worden Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode 4th Ringberg Symposium on Giant Virus Biology In-plaque mass spectrometry imaging (Nature Micro) Infection by brown tide virus, AaV (Front Micro) Choano virus with a rhodopsin photosystem (PNAS) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv

Revise - A Level and GCSE Revision
A Level Chemistry - Mass Spectrometry

Revise - A Level and GCSE Revision

Play Episode Listen Later May 22, 2019 9:07


Spectrometry being a pain in the mass? Jono breaks down the fundamentals of mass spectrometry for your A Level chemistry exam. In this episode, he will look at how mass spectrometry works and how the results are analysed. Ideal for preparing you for your A Level Chemistry exam. For more info visit: https://www.senecalearning.com/blog/a-level-chemistry-revision/.

ideal jono mass spectrometry spectrometry level chemistry
Revise - A Level Chemistry Revision
A Level Chemistry - Mass Spectrometry

Revise - A Level Chemistry Revision

Play Episode Listen Later Apr 15, 2019 9:10


Spectrometry being a pain in the mass? Jono breaks down the fundamentals of mass spectrometry for your A Level chemistry exam. In this episode, he will look at how mass spectrometry works and how the results are analysed. Ideal for preparing you for your A Level Chemistry exam. For more info visit: https://www.senecalearning.com/blog/a-level-chemistry-revision/.

ideal jono mass spectrometry spectrometry level chemistry
The Drug Discovery World Podcast
The Mass Spectrometry Innovations Simplifying Drug Discovery Workflows

The Drug Discovery World Podcast

Play Episode Listen Later Dec 18, 2018 19:02


Mass spectrometry (MS) has long been a valuable tool for drug discovery, and steady advances in its capabilities and performance have generated powerful insights for the pharmaceutical industry. The latest MS innovations are now helping biotherapeutics developers overcome challenges around sample preparation and large molecule analysis. The use of mass spectrometry in pharmaceutical discovery and development is rich and varied, spanning a wealth of applications from target discovery, medicinal chemistry, pharmacokinetics and bioanalysis workflows, to name just a few. Offering the selectivity, specificity and sensitivity required to answer a broad range of analytical questions, mass spectrometry has become one of the most powerful tools in the drug discovery toolbox. Mass spectrometry is a particularly powerful tool for the discovery and development of biotherapeutics. Today, biotherapeutic products account for a growing proportion of new drug approvals. Increased focus on the development of much larger, more complex therapeutics such as monoclonal antibodies, fusion proteins and antibody-drug conjugates has placed new demands on mass spectrometry. Original article by Helen Stewart-Miller and Dr Richard Massey If you'd like to view the original article then follow the link below: https://www.ddw-online.com/summer-2018-teasers/p322386-the-mass-spectrometry-innovations-simplifying-drug-discovery-workflows.html You can also download the original article pdf here: https://www.ddw-online.com/media/32/131034/(4)-the-mass-spectrometry-innovations-simplifying-drug-discovery.pdf For more information on Drug Discovery World, head to: https://www.ddw-online.com

Lawrence Livermore National Lab (Video)
Improving Human Health One Atom at a Time - Biomedical Accelerator Mass Spectrometry

Lawrence Livermore National Lab (Video)

Play Episode Listen Later Jun 18, 2018 43:01


Accelerator mass spectrometry (AMS) is a sensitive mass spectrometric method for detecting and quantifying rare long-lived isotopes with high precision. This technique is widely employed in the earth and environmental sciences and is now being applied in the biomedical fields. AMS is primarily used to in the areas of pharmacology and toxicology to investigate the absorption, distribution, metabolism, and excretion of radiolabeled drugs, chemicals, and nutrients, as well as in the detection of chemically modified DNA and proteins in animal models and humans. The exquisite sensitivity (10-18 mol) of AMS allows for the use of low chemical and radioisotope doses and relatively small sample sizes, which enables studies to be performed safely in humans, using exposures that are environmentally or therapeutically relevant. Series: "Lawrence Livermore National Lab Science on Saturday" [Science] [Show ID: 33431]

Lawrence Livermore National Lab (Audio)
Improving Human Health One Atom at a Time - Biomedical Accelerator Mass Spectrometry

Lawrence Livermore National Lab (Audio)

Play Episode Listen Later Jun 18, 2018 43:01


Accelerator mass spectrometry (AMS) is a sensitive mass spectrometric method for detecting and quantifying rare long-lived isotopes with high precision. This technique is widely employed in the earth and environmental sciences and is now being applied in the biomedical fields. AMS is primarily used to in the areas of pharmacology and toxicology to investigate the absorption, distribution, metabolism, and excretion of radiolabeled drugs, chemicals, and nutrients, as well as in the detection of chemically modified DNA and proteins in animal models and humans. The exquisite sensitivity (10-18 mol) of AMS allows for the use of low chemical and radioisotope doses and relatively small sample sizes, which enables studies to be performed safely in humans, using exposures that are environmentally or therapeutically relevant. Series: "Lawrence Livermore National Lab Science on Saturday" [Science] [Show ID: 33431]

Clinical Chemistry Podcast
Mass Spectrometry–Based Adrenal and Peripheral Venous Steroid

Clinical Chemistry Podcast

Play Episode Listen Later Apr 19, 2016 14:43


Primary aldosteronism,also known as Conn's syndrome,is a form of endocrine hypertension that results from excess product of aldosterone by the adrenal glands.

Clinical Chemistry Podcast
US Food and Drug Administration Perspectives on Clinical Mass Spectrometry

Clinical Chemistry Podcast

Play Episode Listen Later Jan 27, 2016 8:52


Mass spectrometry–based in vitro diagnostic devices that measure proteins and peptides are underutilized in clinical practice, and none has been cleared or approved by the Food and Drug Administration (FDA) for marketing or for use in clinical trials. One way to increase their utilization is through enhanced interactions between the FDA and the clinical mass spectrometry community to improve the validation and regulatory review of these devices.

Clinical Chemistry Podcast
Ambient Ionization Mass Spectrometry for Point-of-Care Diagnostics and Other Clinical Measurements

Clinical Chemistry Podcast

Play Episode Listen Later Jan 8, 2016 21:36


A driving force in the development of point-of-care diagnostics is to conveniently provide information without delay so that healthcare decisions can be made while the patient is on-site. Most point-of-care devices are based on immunochemical, electrochemicalor colorimetric techniques that can be miniaturized and made portable.

Clinical Chemistry Podcast
High-Resolution Mass Spectrometry for Characterizing the Metabolism of Synthetic Cannabinoid THJ-018 and Its 5-Fluoro Analog THJ-2201 after Incubation in Human Hepatocytes

Clinical Chemistry Podcast

Play Episode Listen Later Jan 4, 2016 19:49


Despite increasing prevalence of novel psychoactive substances, no human metabolism data are currently available, complicating laboratory documentation of intake in urine samples and assessment of the drugs' pharmacodynamic, pharmacokinetic, and toxicological properties. In 2014, THJ-018 and THJ-2201, synthetic cannabinoid indazole analogs of JWH-018 and AM-2201, were identified, with the National Forensic Laboratory Information System containing 220 THJ-2201 reports. Because of numerous adverse events, the Drug Enforcement Administration listed THJ-2201 as Schedule I in January 2015.

Clinical Chemistry Podcast
Mass Spectrometry Selectivity, Specifically

Clinical Chemistry Podcast

Play Episode Listen Later Jan 4, 2016 10:05


A mass spectrometer is a sensitive and specific instrument." In some form or another, this is often the label applied to the platform by all manner of professions (chemists, physicists, biologists, physicians, clinicians, and laboratorians, novice and expert alike). This is a view of mass spectrometry (MS) through rose-colored glasses. It should be properly said that MS can be sensitive and specific, but not without due consideration for the measurement to be performed. In clinical laboratories, this measurement is the extraction, detection, and often, quantification of a compound of interest from a biological matrix.

This Week in Virology
TWiV 358: Virology and proteomics with Ileana Cristea

This Week in Virology

Play Episode Listen Later Oct 11, 2015 83:55


Host: Vincent Racaniello Guest: Ileana Cristea Vincent meets up with Ileana at Princeton University to talk about how her laboratory integrates molecular virology, mass spectrometry-based proteomics, and bioinformatics to unravel the interplay between virus and host.   Links for this episode Cristea Laboratory Ileana's work previously on TWiV 269 Blowing off steam (Cell Host Micr) Nuclear viral DNA sensors (J Biol Chem) mSystems Video of this episode - view at YouTube (coming soon!) Send your virology questions and comments to twiv@twiv.tv

Today In Space
TIS#052 10/01/15 A Super Blood Moon & Martian Water(?)

Today In Space

Play Episode Listen Later Oct 1, 2015 40:41


Welcome to the show! This week, Alex talks about the Super Blood Moon & just how difficult photography really is. He also goes over how NASA used their science-magic to find water evidence on Mars. Well, mushy salt streaks called RSL's. Get the whole scoop on the newest finding on Mars. Enjoy! This Podcast is brought to you by:   AMAZON.COM: SHOP HERE TO SUPPORT THE PODCAST   SUPER MOON/TOTAL LUNAR ECLIPSE "A NEW ENGLAND SUPER MOON TOTAL LUNAR ECLIPSE " - AN ANIMATED GIF CREDIT: Alexander & Nik Orphanos Check out the new "Projects" blog for more pictures & what it was like to try out some Astro-photography Space Links: Great Explanation of the Super Moon Total Lunar Eclipse from NASA https://www.youtube.com/watch?v=vKAw_wrIr5s "Enhanced Falcon 9 Booster Raises Excitement, Concern, As Return to Flight Date Nears" - AmericaSpace.com http://www.americaspace.com/?p=86711 "Crew Access Tower Stacking Passes Midway Point" - Commercial Crew Program/NASA Blog https://blogs.nasa.gov/commercialcrew/2015/09/25/crew-access-tower-stacking-passes-midway-point/ "Veteran Uses a 3D Printer to Create a Replica of the Bullet that Paralyzed Him" - 3DPrint.com http://3dprint.com/98195/veteran-3d-printed-bullet/ "NASA Confirms Evidence That Liquid Water Flows on Today's Mars" - Mars.JPL.NASA.gov http://mars.jpl.nasa.gov/news/whatsnew/index.cfm?FuseAction=ShowNews&NewsID=1858 "Salty Water Flows on Mars Today, Boosting Odds for Life" - Space.com http://www.space.com/30673-water-flows-on-mars-discovery.html

Clinical Chemistry Podcast
Immunoextraction - tandem mass spectrometry method for measuring intact human chorionic gonadotropin, free beta, and beta core fragment in urine

Clinical Chemistry Podcast

Play Episode Listen Later Aug 18, 2014 13:06


Analysis of Human Chorionic Gonadotropin or hCG is usually associated with monitoring or detecting pregnancy. It is also a protein tumor marker for some cancers. In males, hCG stimulates testosterone production and has the potential to be abused by athletes in an attempt to enhance performance in sports.

Clinical Chemistry Podcast
Interlaboratory Agreement of Insulin-like Growth Factor 1 Concentrations Measured by Mass Spectrometry

Clinical Chemistry Podcast

Play Episode Listen Later May 19, 2014 12:33


This is a podcast from Clinical Chemistry, sponsored by the Department of Laboratory Medicine at Boston Children's Hospital.

Clinical Chemistry Podcast
Measurement of Thyroglobulin by Liquid Chromatography–Tandem Mass Spectrometry in Serum and Plasma in the Presence of Antithyroglobulin Autoantibodies

Clinical Chemistry Podcast

Play Episode Listen Later Jun 17, 2013 6:38


Measurement of serum thyroglobulin may be complicated by the presence of endogenous anti-thyroglobulin auto-antibodies which have the potential to interfere with immunoassays and cause false negative results.

Molecular Science: Spectrometry - for iPod/iPhone
Transcript -- Molecular Science: Spectrometry

Molecular Science: Spectrometry - for iPod/iPhone

Play Episode Listen Later Apr 12, 2010


Transcript -- A short introduction to this album.

molecular science spectrometry
Molecular Science: Spectrometry - for iPod/iPhone
Molecular Science: Spectrometry

Molecular Science: Spectrometry - for iPod/iPhone

Play Episode Listen Later Apr 12, 2010 0:56


A short introduction to this album.

molecular science spectrometry
Molecular Science: Spectrometry - for iPad/Mac/PC
Transcript -- Molecular Science: Spectrometry

Molecular Science: Spectrometry - for iPad/Mac/PC

Play Episode Listen Later Apr 12, 2010


Transcript -- A short introduction to this album.

molecular science spectrometry
Molecular Science: Spectrometry - for iPad/Mac/PC
Molecular Science: Spectrometry

Molecular Science: Spectrometry - for iPad/Mac/PC

Play Episode Listen Later Apr 12, 2010 0:56


A short introduction to this album.

molecular science spectrometry
Molecular Science: Spectrometry - for iPad/Mac/PC
Transcript -- Infra-red Spectrometry

Molecular Science: Spectrometry - for iPad/Mac/PC

Play Episode Listen Later Jun 22, 2009


Transcript -- Preparing samples for infra-red spectroscopy

infrared spectrometry infrared spectroscopy transcript preparing
Molecular Science: Spectrometry - for iPad/Mac/PC

Preparing samples for infra-red spectroscopy

preparing infrared spectrometry infrared spectroscopy
Molecular Science: Spectrometry - for iPod/iPhone
Transcript -- Infra-red Spectrometry

Molecular Science: Spectrometry - for iPod/iPhone

Play Episode Listen Later Jun 22, 2009


Transcript -- Preparing samples for infra-red spectroscopy

infrared spectrometry infrared spectroscopy transcript preparing
Molecular Science: Spectrometry - for iPod/iPhone

Preparing samples for infra-red spectroscopy

preparing infrared spectrometry infrared spectroscopy
Lawrence Livermore National Lab (Audio)
Accelerator Mass Spectrometry: How AMS Works in Biology and Health Care

Lawrence Livermore National Lab (Audio)

Play Episode Listen Later May 26, 2008 49:15


Carbon dating is a technology borne out of archeologists' desire to date ancient artifacts but it has also spawned exciting applications in biomedical science. Techniques refined at Lawrence Livermore National Lab’s Center for Accelerator Mass Spectrometry are being used to address research questions as diverse as the age of the DNA in our brains to how long chemicals remain in our bodies. Research Scientist Ken Tutereltaub and high school teacher Bret States highlight the principles of carbon dating and how AMS technology is being used to provide insights into challenging problems in biomedicine. Series: "Lawrence Livermore National Lab Science on Saturday" [Science] [Show ID: 14493]

Lawrence Livermore National Lab (Video)
Accelerator Mass Spectrometry: How AMS Works in Biology and Health Care

Lawrence Livermore National Lab (Video)

Play Episode Listen Later May 26, 2008 49:15


Carbon dating is a technology borne out of archeologists' desire to date ancient artifacts but it has also spawned exciting applications in biomedical science. Techniques refined at Lawrence Livermore National Lab’s Center for Accelerator Mass Spectrometry are being used to address research questions as diverse as the age of the DNA in our brains to how long chemicals remain in our bodies. Research Scientist Ken Tutereltaub and high school teacher Bret States highlight the principles of carbon dating and how AMS technology is being used to provide insights into challenging problems in biomedicine. Series: "Lawrence Livermore National Lab Science on Saturday" [Science] [Show ID: 14493]