Podcasts about Clinical chemistry

As the Association for Diagnostics & Laboratory Medicine's (ADLM's, formerly AACC's) Clinical Chemistry journal celebrates its 70th anniversary, Laborastories host Dr. Anthony Killeen sits down with Dr. Jason Park. Together, they look back on the journal's history — and look forward to where Clinical Chemistry and research in the field of laboratory medicine are heading next. With special guest: Dr. Jason Park  Hosted by: Dr. Anthony Killeen

Reference: Agnello et al. Monocyte distribution width (MDW) as a screening tool for early detecting sepsis: a systematic review and meta-analysis. Clinical Chemistry and Laboratory Medicine 2022; 60(5):786-792 Clin Chem Lab Med. 2022 Date: February 21, 2025 Guest Skeptic: Dr. Aaron Skolnik is an Assistant Professor of Emergency Medicine at the Mayo Clinic Alix School […] The post SGEM#468: Wide Open Monocytes – Using MDW to Diagnose Sepsis first appeared on The Skeptics Guide to Emergency Medicine.

What if we've been measuring strength all wrong? Dr. Rhonda Alexander challenges the conventional yardstick of strength, particularly for women in entrepreneurship. We unpack the burden of societal expectations, which equate strength with enduring adversity, and how this leads women to impose relentless standards upon themselves. Drawing from Dr. Rhonda's book "Seven Dirty Secrets of a Strong Black Woman," we question whether true strength lies not in flawless performance but in acknowledging and addressing one's own needs.It's time to reconsider the concept of strength through the lens of self-awareness and boundary-setting. We highlight the pitfalls of overcommitment, especially for those who naturally extend themselves too far in corporate and entrepreneurial settings. By setting clear boundaries and recognizing personal limits, women and minorities can rise above burnout. This empowers them to positively impact their environments, nurturing from a place of fullness rather than exhaustion.We also look at the intricate dance between trauma and leadership, emphasizing the importance of moving beyond mere acknowledgment to genuine healing. Dr. Rhonda shares personal anecdotes, illustrating the transformative power of therapy and sustained effort in overcoming deep-seated traumas. If you've ever identified as an ambitious or high achieving woman, this is an episode you won't want to miss.Guest Bio:Meet Dr. Rhonda Alexander— a force of nature in the world of entrepreneurship, strategy, and leadership. She's the brains behind IUVO Consulting, E-Squared Coaching, and SoulScribe, helping experts turn their knowledge into business gold. Dr. Rhonda doesn't just teach success—she lives it. With three powerhouse books under her belt, including EntrHERpreneur and Your Life's Calling, she's a master at turning ambition into action.Her memoir, 7 Dirty Secrets of a Strong Black Woman, hits bookshelves this January 2025. It's a raw and powerful story that will shift the conversation around what it means to be “strong.”With a background that includes degrees in Molecular Biology, Clinical Chemistry, Public Administration, and a Doctorate in Strategic Leadership, Dr. Rhonda has the expertise to get results. With nearly 30 years of experience leading teams and growing businesses, Dr. Rhonda's the one to call when it's time to level up.Connect with Dr. Rhonda:www.meetwithdrrhonda.net https://www.soulscribe.nethttps://www.linkedin.com/in/thedrrhondaPreorder 7 Dirty Secrets of a Strong Black Woman here: www.7dirtysecrets.netWant to hear the episode on mental health challenges for entrepreneurs I reference this week? Check it out here: https://podcasts.apple.com/ca/podcast/business-blasphemy/id1663984744?i=1000621497698Support the showConnect with Sarah: Tired of being the "best kept secret"? Download the FREE Thought Leader's Playbook for 5 essential steps to to ignite your influence and get noticed! Get Your Playbook HERE Follow Sarah on Instagram (instagram.com/corporate.rehab) Learn how to work with her HERE (getcorporaterehab.com/services) The Business Blasphemy Podcast is sponsored by Corporate Rehab® Strategic Consulting.

Dr. Shoreh Ershadi is the founder of ANITAGING Institute of California and a renowned expert in clinical biochemistry and pharmacology with over 40 years of experience. Dr. Ershadi shares her compelling journey from Iran to the United States, highlighting her unexpected entry into medical technology and the numerous challenges she faced as a woman in science. From setting up clinical labs and pioneering AIDS testing to founding her own antiaging company, Dr. Ershadi discusses her relentless pursuit of scientific innovation and passion for improving human health. The conversation also touches on her entrepreneurial ventures, the role of art in her life, and her vision for a healthier future driven by natural apoptosis-promoting supplements. Guest links: www.Apoptosis.us | www.facebook.com/apoptosisnutraceuticals | www.instagram.com/apoptosisnutraceuticals | www.threads.com/apoptosisnutraceuticals  Charity supported: Save the Children Interested in being a guest on the show or have feedback to share? Email us at podcast@velentium.com.  PRODUCTION CREDITS Host: Lindsey Dinneen Editing: Marketing Wise Producer: Velentium   EPISODE TRANSCRIPT Episode 037 - Dr. Shoreh Ershadi [00:00:00] Lindsey Dinneen: Hi, I'm Lindsey and I'm talking with MedTech industry leaders on how they change lives for a better world. [00:00:09] Diane Bouis: The inventions and technologies are fascinating and so are the people who work with them. [00:00:15] Frank Jaskulke: There was a period of time where I realized, fundamentally, my job was to go hang out with really smart people that are saving lives and then do work that would help them save more lives. [00:00:28] Diane Bouis: I got into the business to save lives and it is incredibly motivating to work with people who are in that same business, saving or improving lives. [00:00:38] Duane Mancini: What better industry than where I get to wake up every day and just save people's lives. [00:00:42] Lindsey Dinneen: These are extraordinary people doing extraordinary work, and this is The Leading Difference. Hello, and welcome back to another episode of The Leading Difference podcast. I'm your host, Lindsey, and today I'm so excited to introduce you to my guest, Dr. Shoreh Ershadi. With over 40 years of expertise in clinical biochemistry and pharmacology, Dr. Ershadi stands at the forefront of scientific innovation in the field of nutraceuticals and supplements. Board certified by the American Academy of Antiaging Medicine and holding dual doctorate degrees, Dr. Ershadi brings a wealth of knowledge and experience to the world. Dr. Ershadi's distinguished credentials, including National Registry in Clinical Chemistry and Toxicology and American Society of Clinical Pathology certifications, underscore her dedication to precision and quality in laboratory practices. Her visionary leadership and unwavering passion for advancing human health has made her a trusted authority in the field. All right. Well, Shoreh, thank you so much for being here today. I'm so excited to speak with you. [00:01:51] Dr. Shoreh Ershadi: Thank you for having me. I'm very excited to talk to you, especially that you're going to talk about medical technology. And that is something that I have been doing or working at for, I would say over 30 years, easy. 1988, I got my license in California. So it's what, 32 years? [00:02:17] Lindsey Dinneen: Yeah. Excellent. Oh my goodness. Well, this leads perfectly into my first question and that is, can you tell us a little bit about yourself and your background and how you got into medtech? [00:02:29] Dr. Shoreh Ershadi: Okay. That is interesting because I was born in Iran and I studied pharmacology. And before I was graduated, the Department of Health in Iran was hiring pharmacists, pharmacologists. So we all went and took the exam and we passed the exam. We were still at the final stages of doing the thesis and going through final stages of graduation. And then they called me and a few other people for an interview. Apparently I had a high mark in the test, which I did not know. So when we went for the interview, and I went to an American school and then later to a British school in Iran, so I was speaking English. At the interview, there was a gentleman who was back in Iran from United States, and he was a PhD in clinical biochemistry, and he asked me to read something in English. And I read it, and he thought that I had it by heart or something, so he flipped the book and found a more difficult page and said, "Okay, read this," and I read that, and he said, "Okay, I'm hiring you for the reference lab." I had absolutely no clue what he was talking about, what was reference lab. I had no intention to even work for Department of Health because I was not even graduated at that time. And then they said, "Okay, start on such and such date." And when I went there the first day, he said he spoke in English and he said, "You're overqualified." Oh my God. What? I mean, it was funny. Without even planning to get into laboratory, I got into the reference lab of Department of Health. And what he was planning to do was to bring College of American Pathologists, the proficiency testing to all the laboratories in Iran. And he wanted someone who would speak English and who could communicate. So first day of my job, I wrote a letter to College of American Pathologists and I said, "Hi, hello, I'm Shoreh Ershadi, I want to buy a thousand proficiency kits." And of course they responded. So just like that, I got into clinical laboratory. And I became the Director of the Quality Control for Department of Health. And that was before the revolution. So, that was my exciting start into laboratory. [00:05:25] Lindsey Dinneen: Yeah, that's an incredible story. Thank you for sharing that. And [00:05:28] Dr. Shoreh Ershadi: Not voluntarily, but serendipitously, yes. [00:05:34] Lindsey Dinneen: There you go. So then at some point, you came to the U. S. and was that transition really difficult? Was it frustrating? Were you excited? Nervous? [00:05:47] Dr. Shoreh Ershadi: There was a part in between before coming to U. S. There was another test by W. H. O., World Health Organization. So I took that test and I passed that test and I got a scholarship to go to medical school in England to do a master's degree. And when I went there, I told them, "I already have a doctorate in pharmacology. I don't want master's. I want to do PhD." And after a few weeks, they said, "Okay, fine, go to PhD. You don't need to do master." So I was in England for about four years. I did my PhD in clinical biochemistry. And I went back to Iran. That was exactly during the revolution. So while I was studying in England, the country in Iran was on fire. It was, things going crazy everywhere. But I went back and I got married. I had my son in Iran, and I was working in a clinical laboratory in one of the best hospitals in Iran, and it got very difficult for women to work. They were saying, " Now you have to wear a scarf. Now, you can't see male patients, you can only talk to female patients." It was not right. So, 1984, I came to United States, I came to California, and with some friends in Iran who had a clinical laboratory, and they were here before me and had started a lab in Orange County, California. I started a branch of the lab in Westwood, in Los Angeles. So that was my first job or position and that was my entrepreneurial side, which now I wouldn't dare to start a life, but then I did. [00:07:51] Lindsey Dinneen: You didn't know the difference then. [00:07:53] Dr. Shoreh Ershadi: Well, yes, I didn't know. I mean, it was a lot easier, I would say. At that point. The lab was not even accepting Medicare or Medi Cal. It was private insurance. I was doing the billing. I was getting the information. I was drawing the patients. I was separating the samples and sending them to the reference lab that was actually running the tests. But I was doing stat CBCs and I was in a medical building and so all the doctors were so nice to send the samples down to me. It worked. So [00:08:33] Lindsey Dinneen: Amazing. Oh my. [00:08:34] Dr. Shoreh Ershadi: Amazing. Yes. Now it sounds really amazing. It's surreal in a way. Yeah. [00:08:42] Lindsey Dinneen: Yeah. Yeah. Well, so, so with that lab and embracing this entrepreneurial journey, and I'm so thankful it worked out so well for you, but were there any moments where you just thought, okay, I've, I, you have such an amazing background. You're so highly educated, you're brilliant. And then you're starting this entrepreneurial journey, which is kind of a different skill set in a way. How was that transition of becoming kind of your own boss and being in charge of everything? [00:09:12] Dr. Shoreh Ershadi: That was pure ignorance. I mean, now I can say then, I thought I knew what I was doing, but it was a fast learning. First that I was in a different country, that I had never been in the United States. Second, that I had a three year old son that I brought with me and my then husband never came, so I got a divorce and I became a single mom. So, and nobody else was from my family was here. So it was very difficult because I had to take him to daycare and then come work and then go pick him up. And then there was a war, the Iraq war had started in Iran and my parents were in Iran and I was going through a divorce, so it was turmoil. And I had to work and learn in a way it was good because it didn't give me time to think about anything else. It was just forward, no looking sideways, no looking backwards. It was just moving forward. But then again, something else happened that made it even more interesting. One of the days that I was at the lab, some guy came and said, "CDL, Central Diagnostic Lab, is looking for a technical director and they've asked me to come and talk to you." I had absolutely no clue if anyone knew me or knew of me or it was the, I mean, a lot of things happened, which, I mean, I'm happy now, but then it changed my life tremendously. And I don't think I've ever talked to anyone about this in this detail. So, Lindsey, I would say you're the first person I'm telling the story of my life. But anyways, I went for an interview and I got hired right away. I had the lab, so I hired someone to do the work that I was doing in the lab. And then I started working at CDL, Central Diagnostic Labs, which was the largest privately owned lab in the United States at that time. There were 1, 200 employees. So that was a very interesting experience on its own because I was introduced to a world that I did not even know what was going on. So, and that was during AIDS testing. Bio-Rad had just come up with Western blot testing and we did the clinical trial, which was very easy in those days. We had AIDS patients and we had a lot of AIDS samples accumulated or saved frozen and we used them to validate the Western blot by Bio-Rad and I went on National TV 1988 and I said, "CDL is the first lab in the world that is doing a confirmation for HIV AIDS testing." So then, that was major. [00:12:40] Lindsey Dinneen: Yes. [00:12:43] Dr. Shoreh Ershadi: But then, then my family came. My father passed away here. It was, again, a lot of complications going on. And one of the other people that I knew asked me to go and partner with them in a lab. Again, my entrepreneurial part took over and I went for the partnership, and I started from scratch. I started Path Labs practically from scratch. There were two pathologists working with Los Alamitos Hospital, and I went there and I started a lab from just buying test tubes, buying, from absolutely nothing. I was there for six years, I think. six or eight years with Path Labs. That was not so successful. After that, I went to Specialty Labs, which is now Quest. Specialty wanted to start a toxicology lab. So, Path Lab was sold. But there was no money made with the partnership and all that. So that was not a very successful six, eight years of my life. Specialty was good. I went to Specialty and I started Department of Toxicology. I don't know if you remember or you were familiar with specialty. Dr. Peters was there and he was the founder, James Peters. He did only immunology testing. They would receive samples and send out everything else to other labs and only do the immunological tests or some specialty tests. When I started the toxicology department, we started getting samples from all over the world. We were running heavy metals and all that. We had an ICP MS and I started running ICP, and the main test that I developed there was measuring iron in the liver biopsy of patients with hemochromatosis. So we would get one spot, in tip of the needle of the liver and then do a measurement and measure the amount of toxicity with iron in hemochromatosis, which was great. I wrote a paper and we were working with Mayo Clinic and they developed the test. So that was very exciting. Then I started the automated lab because all the chemistry. And all the hematology was going out, was sent out. So that brought a lot of money into the lab, but that was not my lab. It was Dr. Peter's lab. It was wonderful. It was nice. But he was the entrepreneur there. So in the year 2000, I started ANTIAGING Institute of California. After passing the specialist chemist license in California, I got National Registry in Certified Chemistry, Certified Toxicology, and then I took the board exam with American Academy of Antiaging Medicine. And that was again entrepreneurial and I started the company, that would be 25 years ago. I've done a lot of consultation. I've been director of lab during COVID. I went back to city health. And I was Director of City Health running 4, 000 COVID patients a night for airports, for schools, for traveling, for a lot of stuff. And then I worked with Siemens Healthineers on regulations for IVDR. So all the kits that Siemens had, over 700 reagent kits that were sold to the laboratories, they need to get the CE mark to be able to be sold in Europe under the new IVDR regulations. And a lot of it had to go through FDA as well because FDA had to approve if there were any changes made to the kits. So I've done a lot of regulation works. I've done a lot of hands on COVID tests, covered it all. Actually, something else that was very interesting. And this, for MedTechs, I would think this would be interesting to know that it's not just one position. And there's so much you can do, if you want to expand your horizon. For about a year, I helped set up extremely high complex laboratory for testing mother's milk, for making milk bank from mother's milk for NICU for children who were born early and the formulas did not work with them. Some of them were so tiny, less than a pound. And so mother's milk bank, it's called Prolacta Bioscience, the company. And I worked there to establish the clinical lab and to get a license for clear and stuff like that. So. [00:18:21] Lindsey Dinneen: Oh! [00:18:21] Dr. Shoreh Ershadi: A lot of good work going into my up and down career, I would say. [00:18:28] Lindsey Dinneen: I love it. Well, first of all, I'm so honored that you were willing to share so much with me. That is. I really appreciate it. And I really appreciate you being willing to talk about some of the amazing moments you've had and the really high, " Yay, we did this," but also some of the moments where it was a little bit tougher and even you being honest and transparent about, the one company didn't do as well as you would have hoped, but you kept going and you are a living testament to resilience and adaptation. [00:18:59] Dr. Shoreh Ershadi: There is no other choice. I would hope that people would have many choices. I mean, you always make choices in life. Even now, this is a choice to talk to you and I appreciate the opportunity because, if I would choose or if I wouldn't know about you, that would be a totally different episode in my life. So I'm open to take chances. You can say that with my experience, living in three different continents and moving and just leaving Iran and coming to us with a three year old, not being here ever before. And then, just jumping in and, but there was no other choice except for moving forward, or we can say, except for success. Because failure was not an option. What would I do? There was nowhere to go back. Sometimes you may have an option to make a U turn and say, "Okay, I don't like this. I want to do something else. I want to stay home." There was no option, no going back. So it was only forward. [00:20:09] Lindsey Dinneen: Yes, absolutely. So, coming here and like you said, having to move forward and I appreciated what you said, you kind of, you couldn't look to the side, you couldn't look back. You had to keep moving forward. How did you go about building a community that could support you, that you could be friends with, and colleagues with, and feel supported coming in from, not having that. [00:20:36] Dr. Shoreh Ershadi: And that was not very difficult. There were many difficult times during that, that I mean, I don't mind talking about it, being a woman, being a young woman, being from a different background there was a lot of resistance. And I see that today as well. I mean, I can't say, "Oh, here I'm in L. A. and Los Angeles is so easy." It's not. I am hoping that women would not maybe experience all the difficulties that I went through. But we're talking about 40 years ago. I came to The States actually July 22nd would be exactly 40 years. I left Iran July 1st, 1984. So this is the 40th anniversary. Being a woman, I thought, when I went to England one of the first things, the professor was my direct supervisor when I worked with him. And I know you can see my face. This is 40 years later. I have no claims, but the professor told me, "You're a beautiful woman. Why do you want to study? Why are you here for PhD?" And I thought that was the greatest insult in my life. So I fought with that professor for four years. [00:22:15] Lindsey Dinneen: No, I'm sorry. [00:22:17] Dr. Shoreh Ershadi: That wasn't easy, but it was so difficult to prove that I am not just a woman or a pretty girl or a young girl or a young woman, or. That was a major fight. I would say that was as difficult as fighting the revolution in Iran, because you wouldn't expect a British professor to say that to you. And I was the only girl, a PhD student, all the others were guys, and this was medical school. And to me, that was very surprising because when I went to University of Tehran, we had probably more girls than guys in the class. Girls were very prone to education in Iran, and they still are. There's still, I think, 60, 65 percent girls in universities, even here. But to hear that was very difficult. That experience repeated itself. in United States over and over till today that I can say I don't feel old. I'm antiaging, but now that I'm an old woman, I still feel that I have to prove myself that I am equal. And sometimes I would say I'm better, but, just to be honest and modest, you want to be treated equal. And that is very difficult. [00:23:53] Lindsey Dinneen: Yeah. Yeah, you're absolutely right. And As much as I would wish things were improving rapidly, I'm not so sure that they are, but what have you found has been helpful in terms of, helping people understand who might come with a bias, but who, helping those people understand, "No I have this education. I am very capable." What are some strategies that you have found that have worked really well for you? [00:24:22] Dr. Shoreh Ershadi: Not many. I have to be honest with you. I mean, if there are a few people, few women, a few even men who are, would be following the conversation, I want them to know that this is not easy. And maybe a part of my success is that I'm a fighter. And I didn't surrender, but I didn't smile my way up. I fought with everyone that went in that direction. And I don't want to get into details, but many of the stronger men would think that if they flirt with you, if they take you out, if they buy dinner for you, then you're going to do what they say. And my story is, just, I have my guards up and I fought. I wouldn't recommend people to fight. Maybe they can find a better solution. I did not find many. Maybe the reason of working separate and starting my own company, maybe one of the major reasons was that I would not have to say yes to power that I did not want to say yes. I worked very hard. I worked hard, long hours. Medtechs, you have to stay there to get the results out. One Christmas. I stayed from December 24th for I would say 72 hours in the lab, maybe two, three hours shower and sleep and go back because we had a lot of toxicology tests that were waiting and results had to go out. And the probe in the I-C-P-M-S was broken. There was no one to replace it during Christmas. It was, we had to borrow from somewhere, FedEx shipping it. Those things happen, you know that, and you have to work hard. It wasn't an easy journey to say, "Oh, I worked four hours a day." And they said, "Thank you. You're so good. Go home." It wasn't like that. [00:26:44] Lindsey Dinneen: Right. Right. Yeah. Well, thank you. I appreciate you sharing that. And so one thing that was really interesting to me, I was looking at your LinkedIn profile and I see that art is a big part of your life in addition to the science and I saw you listed painting and sculpting and I'm wondering how-- well a couple of things-- how did you first get involved in art? And secondly, do you feel that is helpful in terms of having a sort of therapeutic thing to do that kind of maybe helps with some of those harder moments where it's a little frustrating? [00:27:23] Dr. Shoreh Ershadi: Very helpful. But I was as a kid, I started painting at a very young age. And I was always coloring and painting and making things and all that. And my father, a very educated father, he had two master's degree from a University of Texas and came back to Iran. And that's why, we spoke English and we went to English school. So my father was educated and open minded, I can say. But he always said that "You should study art. And don't go to medicine, you'll get old." He passed away in 1988, and I always, when I started Antiaging, I always said "Okay, if you're looking, you will see that I'm antiaging, I didn't age, I went to medical school, I did all the studies." But my logic, first that I love to do this, I mean, it wasn't just you know, forcing myself. I love science. And to this day I do a lot of research. I play with science. You can see the labels are all fancy. I do the paintings. I do all of that. But my logic, more than being scientific, was that this was a career and art would not be a self supporting career, even at younger age. But I always said that if I was a doctor, I could paint, but if I was an artist, I could not do the scientific part or the medical part that I was interested in. But after the divorce, I was in a relationship for 14 years. And I was working hard, raising a son, being a single mother and all that. When that relationship ended after 14 years, the art just popped out. I started painting, sculpting. It was not under control. You can see that, things happen to me, things come out in a certain period. Maybe, I push them down, force them to stay within me, and then they just pop out in different directions. So art came out itself. But there was a period in between that there was no art. Maybe there was too much stress. Maybe there was a lot of, and right now there's no art. Right now it's more entrepreneurial, starting, scientific, all that. But the art pops out every now and then. [00:30:07] Lindsey Dinneen: That's great. Yeah. So speaking of, what you're doing now, I was wondering if you could share a little bit about your company and maybe what you're excited about for its future as you continue along this path. [00:30:19] Dr. Shoreh Ershadi: Okay. That is, this is now where all the passion is. So everything that I have forced inside for all my life is now just coming out into Apoptosis. Apoptosis is a Greek word and it means "falling of the leaves." In science apoptosis, if you Google it, you'll see it means "programmed cell death." So in our bodies in creation or creator or whichever you wanna put it, and I'm sure being a medtech and all the audience, they know there are thousands of reactions inside the body are happening for me just to sit here and breathe and talk. There are thousands and thousands of enzymes and catalysts and metals and oh, whatever is going on. Programmed cell death or apoptosis is a main part of survival. So it's the future of antiaging because we all-- first of all that life expectancy is much longer now. Longevity is longer and younger people do not want to get old. So, at some point I would say my grandmother's generation and my mother is now 95 years old and she's, thank God, healthy and walking and all that, but even she does not want to get old. So, the image of being old and sick is combined together. But we can age without being sick, without getting Alzheimer's, without losing our memory, without getting all these different kinds of diseases. And one major problem is cancer that was much higher with older people and now the statistic is showing that cancer is happening in younger and younger generations. So what apoptosis does is that it's a program in the body. I did not make it. I wish I did, but it's happening all the time. And apoptosis is getting rid of cancer cells, getting rid of damaged cells, getting rid of neurons that cannot connect and synapses with other neurons to take the message over. So if we encourage apoptosis, then all the damaged cells are removed just like falling leaves. They're removed from the body and they're replaced with new energized healthy new cells. Every 10 years, our entire body is regenerated. So why do we get old? We should always stay at a 10 year age. So at 20 years old, we have recycled cells that even though we're growing, growth and youth is defined as between 20 to 25. From 25 to 30, it's sort of stable. There's a plateau. After 30, we start the aging process. So now, as 30 to 60, is still considered not so deep slip going down. It's sort of a plateau up to 60. And then after 60, 70, 80, 90, people are beginning to age. And it shows, I mean, with different diseases, with wrinkles, with memory loss, with all that. So what I'm doing, I'm using nature's product, plant based products, and this has been proven in science that these plants support apoptosis. So, as we get older, just like all the other reactions, apoptosis does not happen at its ultimate way that it should happen. But if we encourage it, for example, we have here, this one is brain beet. This is all beet roots, and it's an organic product. It's all plant based, but it releases nitric oxide. And it works the same way that Viagra works, but it opens all the arteries, it opens the circulation to the brain, to the heart, so why not use it? Why not promote apoptosis the way nature has programmed it in our body, just help it to work better. So that is all my passion right now. [00:35:28] Lindsey Dinneen: Excellent. Excellent. Well, I love that. Thank you for sharing a little bit about it. I'm excited for our listeners to go and learn more about it and, see how they can maybe also take part in the antiaging movement. [00:35:41] Dr. Shoreh Ershadi: Yes, they can partner with us and I would be thrilled. Actually, this is something that maybe I have learned during the long life experience, is that the more partners you have, the more friends you have, the more you share your knowledge, the better it is. Because at some point, it was like people wanted to keep everything to themselves and they didn't want to share or, but right now it's totally different. If they go to Apoptosis.us, they can go to the science section, they can read the papers. And if they would like to partner, I'll be thrilled to work with as many people as possible and take the message out. Yeah, this is a healthy message. This is something that we should all be talking about. [00:36:36] Lindsey Dinneen: Indeed, we should. Yes. Thank you. Well, pivoting the conversation just for fun, imagine that you were to be offered a million dollars to teach a master class on anything you want. It can be in your industry, but it doesn't have to be. What would you choose to teach? [00:36:56] Dr. Shoreh Ershadi: Well, the million dollar would be great. [00:36:59] Lindsey Dinneen: Indeed. [00:37:00] Dr. Shoreh Ershadi: Yes. Yeah. Would we all want that. But yes, I think that right now, as I said, I would use the million dollars to talk about apoptosis all over because I see even young children, every time I see St. Jude's children, and thank you for your donation to Save the Children. I admire that. And I'm hoping that all the children in the world would have a good, healthy future. The world is crazy. You can look at it right now and see that, I can say my experience has been crazy. It doesn't get any better. It's always up and down. Things are happening all over everywhere in the world. And I would like to talk about health, talk about antiaging, talk about Apoptosis and educate more and more of the young people to learn and to avoid all the toxins that we are creating and we have created, with what we're doing with industry and go back to a plant based life, go back to nature, enjoy nature, go back to art, if possible, all the good things that we can do with our lives. [00:38:21] Lindsey Dinneen: Yes, absolutely. And then, how do you wish to be remembered after you leave this world? [00:38:29] Dr. Shoreh Ershadi: Oh, wow. That's a very difficult... a fighter? Survivor? Yep. Strong women? I would support women all the way. Now in Iran, they're saying, Woman Life Freedom. I'm sure you've heard about that. And I cannot tolerate, to see women covered all over with a window to see outside. To me, that is very disturbing. So I would like to see equal opportunity for women and I would like to maybe be remembered as a survivor. [00:39:14] Lindsey Dinneen: Yes, absolutely. And then, final question, what is one thing that makes you smile every time you see or think about it? [00:39:24] Dr. Shoreh Ershadi: Oh, my granddaughter and my grandson. Yes, I have a five year old granddaughter. Her name is Julia and she is my sunshine. She is my life. The grandson is three months old. He's still too young, but he's getting there. [00:39:45] Lindsey Dinneen: Aw! [00:39:48] Dr. Shoreh Ershadi: Getting emotional. [00:39:51] Lindsey Dinneen: I'm so glad. It's that's beautiful. That's wonderful. [00:39:56] Dr. Shoreh Ershadi: Yes, that is continuation of the fight. That is when you see that what you've done is worth the fight, worth the hard work. [00:40:08] Lindsey Dinneen: Absolutely. Absolutely. Yes. Well, this has been amazing. I so appreciate you telling your story and sharing some of it that maybe you haven't done before, and that's I feel very honored. [00:40:23] Dr. Shoreh Ershadi: Yes. [00:40:24] Lindsey Dinneen: Thank you. Thank you for trusting me. [00:40:28] Dr. Shoreh Ershadi: Well, thank you for bringing all of this out. This has been sitting there suffocating, maybe. [00:40:36] Lindsey Dinneen: Yeah. [00:40:37] Dr. Shoreh Ershadi: Thank you. [00:40:38] Lindsey Dinneen: Absolutely. And we are so honored, you mentioned this, but to be making a donation on your behalf as a thank you for your time today to Save the Children, which works to end the cycle of poverty by ensuring communities have the resources to provide children with a healthy, educational, and safe environment. So thank you for choosing that organization to support. And we just wish you the most continued success as you work to change lives for a better world. [00:41:06] Dr. Shoreh Ershadi: Thank you so much, and thank you for having me, and thank you for making me tell the story. Thank you, Lindsey. [00:41:15] Lindsey Dinneen: Of course. And thank you also so much to our listeners for tuning in. And if you're feeling as inspired as I am right now, I would love if you would share this episode with a colleague or two, and we'll catch you next time. [00:41:29] Ben Trombold: The Leading Difference is brought to you by Velentium. Velentium is a full-service CDMO with 100% in-house capability to design, develop, and manufacture medical devices from class two wearables to class three active implantable medical devices. Velentium specializes in active implantables, leads, programmers, and accessories across a wide range of indications, such as neuromodulation, deep brain stimulation, cardiac management, and diabetes management. Velentium's core competencies include electrical, firmware, and mechanical design, mobile apps, embedded cybersecurity, human factors and usability, automated test systems, systems engineering, and contract manufacturing. Velentium works with clients worldwide, from startups seeking funding to established Fortune 100 companies. Visit velentium.com to explore your next step in medical device development.

The most commonly used equation that determines someone's kidney function includes a binary male-female sex coefficient. But what does this mean for the care of transgender, gender-diverse, and nonbinary people? Cameron Whitley, an associate professor with kidney failure experience, and researchers Keila Turino Miranda, a PhD student, and Dr. David Collister, a nephrologist, shed light on this important topic.   Dr. David Collister (he/him) is a Kidney Doctor, Clinician-Scientist and Assistant Professor at the University of Alberta. He has a PhD in Health Research Methodology from McMaster University. His research program is funded by the Canadian Institutes of Health Research and the Kidney Foundation of Canada and focuses on randomized controlled trials of interventions for uremic symptoms, cannabinoids, the responsiveness of uremic symptoms to the initiation of dialysis, metabolomics, proteomics and the intersection of gender diversity and kidney disease. Keila Turino Miranda (she/her) is a first year PhD Student in the Cardiovascular Health and Autonomic Regulation Laboratory at McGill University. Ms. Turino Miranda's work focuses on understanding and addressing the unique healthcare needs and disparities faced by transgender, gender-diverse, and non-binary (TGD) individuals in the realms of nephrology and cardiology using a patient-oriented approach. Cameron T. Whitley, Ph.D. (he/they) is an Associate Professor in the Department of Sociology at Western Washington University. He studies issues concerning the environment, human-animal relationships, and transgender-affirming medicine. He got involved with studying transgender-affirming medicine when he was diagnosed with kidney failure and received a kidney transplant while writing his dissertation. Through this process, he coauthored one of the first articles addressing the discrepancies in evaluating kidney function for transgender people. He has over five dozen publications featured in places like Proceedings of the National Academy of Sciences, Academic Emergency Medicine, Clinical Chemistry, and Annual Review of Sociology.   Additional resources: Kidney Function in a Gender Diverse Landscape   Do you have comments, questions, or suggestions? Email us at NKFpodcast@kidney.org. Also, make sure to rate and review us wherever you listen to podcasts.

In this episode of The Thyroid Answers Podcast, I discuss Thyroid lab tests, lab values, and the over-prescription of thyroid medication. Topics covered in this episode include:  Optimal vs Lab reference ranges Lab value vs lab interpretation The problem with optimal ranges Seasonal variability and other factors that influence TSH The over-prescription of thyroid medication and More...   Dr. Joe El-Khoury is Associate Professor of Laboratory Medicine at Yale School of Medicine and Director of the Clinical Chemistry Laboratory and fellowship program at Yale-New Haven Health. He is board-certified by the American Board of Clinical Chemistry and a fellow of the Association for Diagnostics and Laboratory Medicine Academy. He currently serves on the Editorial Boards of Clinical Chemistry and Clinical Biochemistry, as Chair of the IFCC Committee on Kidney Diseases, and on the Board of Directors for ADLM. He is the recipient of the 2023 Young Investigator Award from the International Federation for Clinical Chemistry and Laboratory Medicine. He recently launched his own YouTube channel, entitled “Clinical Chemistry with Joe El-Khoury”, which infuses science with comedy and is focused on improving laboratory medicine practice. https://www.youtube.com/@UCYuD1s42xkXSd70QSLRB6ew

In this episode of the Thyroid Answers Podcast I review two recent scientific papers on thyroid physiology with Dr. Kelly Halderman. We break down the important points that are made in the paper so you understand how you might be able to apply the findings to your clients or your own health.  The papers discussed on today's podcast: Yamada S, Horiguchi K, Akuzawa M, Sakamaki K, Shimomura Y, Kobayashi I, Andou Y, Yamada M. Seasonal Variation in Thyroid Function in Over 7,000 Healthy Subjects in an Iodine-sufficient Area and Literature Review. J Endocr Soc. 2022 Apr 6;6(6):bvac054. doi: 10.1210/jendso/bvac054. PMID: 35528829; PMCID: PMC9070835. Joe M El-Khoury, Seasonal Variation and Thyroid Function Testing: Source of Misdiagnosis and Levothyroxine Over-Prescription, Clinical Chemistry, Volume 69, Issue 5, May 2023, Pages 537–538, https://doi.org/10.1093/clinchem/hvad017 Dr. Kelly Halderman has a background in functional medicine, earning her medical doctorate (MD) in 2007 & completing a family practice medicine internship with the University of Minnesota in 2009. She is an international educator in the area of integrative and precision health. Dr. Halderman also has a traditional Naturopathic Medical Degree from KCNH. She holds certification in MethylGenetic Nutrition by The Nutrigenetic Research Institute and certification from The American Functional Neurology Institute in Functional Neurology and Neurofeedback. She is an active member of the American Academy of Anti-Aging Medicine, President and founder of The American Association of Nutraceutical Formulators, and a member of the Physicians Committee for Responsible Medicine and Society of Physician Entrepreneurs. Dr. Halderman has a doctorate in clinical nutrition, is also board certified in Clinical Nutrition by the CNCB, has certification in Plant-Based Nutrition from Cornell University, and health coaching certification from the Institute for Integrative Nutrition. She also has comprehensive experience in nutraceutical science & formulation, creating & educating on novel formulations for consumers, practitioners & professional associations such as the NFL Hall of Fame. A former physician turned executive-level biotech expert, she currently serves as Weo's Chief Health Officer. This health-conscious company harnesses the power of diamond electrolysis to augment the most precious molecule on the planet, water.

The ALL ME® Podcast Human Growth Hormone (HGH) – Does it work? – Dr. Brad Anawalt / Dr. Andy Hoofnagle The ALL ME Podcast is working hard to provide you with information from the World's leading experts when it comes to all things Appearance and Performance Enhancing Substance related.   Throughout the year we ask our listeners to send us topics they'd like to learn more about.  Recently we've been getting asked a lot about Human Growth Hormone (HGH or GH).  Not only have people written in requesting more information on GH, we have had questions from students following our programs.  In order for us to have the best understanding of these drugs we have gone out and found multiple experts to interview on this topic.  In this podcast you're going to hear from two brilliant and highly respected Doctors and Researchers in their field. Dr. Brad Anawalt Bradley Anawalt, M.D., is UW Medical Center's chief of Medicine and a board certified physician at the Endocrine and Diabetes Care Center at UW Medical Center – Roosevelt and Fred Hutchinson Cancer Center. He is also vice chair of UW's Department of Medicine and a UW professor of General Internal Medicine. He has been selected on local and national lists of "Best Doctors." Dr. Anawalt is an hormone specialist whose clinical interests include thyroid disorders, osteoporosis, male infertility, low testosterone and other hormonal abnormalities. He enjoys answering patients' questions and addressing their concerns. Dr. Anawalt earned his M.D. at UC Davis. His primary research interests are focused on the effects of testosterone in men. He has published widely on this topic. He has served in leadership roles in the Endocrine Society and acts as a consultant for the United States Anti-Doping Agency. Dr. Andy Hoofnagle Andy Hoofnagle, M.D., Ph.D., is a board certified pathologist for Laboratory Medicine at UW Medical Center, head of Clinical Chemistry and a UW professor of Laboratory Medicine. Dr. Hoofnagle's lab uses mass spectrometry in the care of patients. In addition, they are currently investigating the role of high density lipoproteins in protecting patients with chronic kidney disease from atherosclerosis. It is his main goal to provide the most accurate testing for every patient in the UW Medicine healthcare system. He feels his talented medical laboratory scientists are in a league of their own. Dr. Hoofnagle earned his M.D. and Ph.D. from the University of Colorado. His clinical and research interests include clinical chemistry, mass spectrometry, proteomics, metabolomics, vitamin D and high density lipoproteins. Both of these gentlemen are going to take the topic of Human Growth Hormone and break it down to where you're able to understand what it is, why is prescribed and how it works.  There is a lot of misinformation out there on this topic and these guys do a great job of providing great information as well as debunking many of the HGH myths. Disclaimer The content in this podcast represents the opinion and knowledge of our guests. This podcast should not be used in any legal capacity whatsoever, including but not limited to establishing “standard of care” in a legal sense or as a basis for expert witness testimony.  No guarantee is given regarding the accuracy of any statements or opinions made on the podcast The content should not be taken as medical advice and is for information purposes only.  Should you have any medical questions please consult your healthcare professional. Resources and Links: Websites:  . What are the risks of HGH treatment? HGH treatment might cause a number of side effects for healthy adults, including: ·         Carpal tunnel syndrome ·         Increased insulin resistance ·         Type 2 diabetes ·         Swelling in the arms and legs (edema) ·         Joint and muscle pain ·         For men, enlargement of breast tissue (gynecomastia) ·         Increased risk of certain cancers Clinical studies of HGH treatment in healthy older adults have been relatively small and short in duration, so there's little to no information about the long-term effects of HGH treatment. Example of Acromegaly According to the Mayo Clinic: Acromegaly is a hormonal disorder that develops when your pituitary gland produces too much growth hormone during adulthood. When you have too much growth hormone, your bones increase in size. In childhood, this leads to increased height and is called gigantism. But in adulthood, a change in height doesn't occur. Instead, the increase in bone size is limited to the bones of your hands, feet and face, and is called acromegaly. Because acromegaly is uncommon and the physical changes occur slowly over many years, the condition sometimes takes a long time to recognize. Untreated, high levels of growth hormone can affect other parts of the body, in addition to your bones. This can lead to serious — sometimes even life-threatening — health problems. But treatment can reduce your risk of complications and significantly improve your symptoms, including the enlargement of your features. Follow Us: ·         Twitter:  @theTHF TikTok:  @theTHF10 ·         Instagram:  @theTHF ·         Facebook: Taylor Hooton Foundation ·         #ALLMEPEDFREE Contact Us:  Email:  Phone: 214-449-1990 ALL ME Assembly Programs:  

On this episode of The Healthcare Plus Podcast, Quint Studer hosts special guest Dr. David Grenache, Chief Scientific Officer of TriCore Reference Laboratories. Quint and David discuss how to replicate best practices, both in leadership and in medicine. Dr. Grenache shares examples of where he's driven change through the implementation of best practices and how he guided his team through those transformations.In their conversation, Dr. Grenache also shares valuable insights on:The critical role laboratory professionals play in predictive and preventative careThe role of AI in healthcareAnd the importance of leveraging tools and insights from laboratory data to impact population healthAbout David G. Grenache, PhD Dr. Grenache is the chief scientific officer for TriCore Reference Laboratories in Albuquerque, New Mexico. In that role, he leads the TriCore Research Institute which helps to innovate healthcare through cutting-edge clinical device trials, advanced central lab services, and a sample biorepository. He is also the laboratory director of TriCore's flagship core laboratory, the medical director of immunology and of point-of-care testing, and a clinical professor of pathology at the University of New Mexico. He is a past president of the Association for Diagnostics and Laboratory Medicine, formerly known as the American Association for Clinical Chemistry. His term as president coincided with the coronavirus pandemic of 2020 and, as such, he helped lead the association through a period of turbulence and uncertainty. Dr. Grenache earned his PhD in biomedical sciences from WPI in Worcester, Massachusetts, and completed postdoctoral training in clinical chemistry at Washington University School of Medicine in St. Louis, Missouri. He has published over 100 research articles, abstracts, and book chapters and is frequently invited to speak at scientific meetings. His research interests are centered on leveraging longitudinal laboratory data to gain insights into individual and population health and the diagnostic tests used to manage the pregnant patient.

Host: Charles Turck, PharmD, BCPS, BCCCP Guest: Zobair M Younossi MD, MPH, FACP, FACG, AGAF, FAASLD Guest: Alan H.B. Wu, PhD Liver disease patients are at an increased risk of major adverse cardiovascular events (MACE), which is why the doctor in today's episode believes the multidisciplinary team plays an essential role in managing these patients. Tune in with Dr. Charles Turck as he speaks with Dr. Zobair Younossi, Chair of the Global NASH Council and Professor of Medicine at the Inova Fairfax Medical Campus in Falls Church, Virginia as well as Dr. Alan Wu, Professor in Laboratory Medicine and is Chief of the Clinical Chemistry and Toxicology Laboratories at San Francisco General Hospital.

On this week's episode, Rich Thayer and Mickey Urdea are exploring metagenomics with Dr. Rick Nolte, an engaging expert on the subject. Dr. Nolte helps to define what metagenomics is, its diagnostic uses, its advantages, and where the field is going. This is a delightfully in-depth interview about a complicated but important topic that is very much worth your time; please enjoy. Frederick (Rick) S. Nolte, PhD, is currently a Senior Director/Medical Advisor at Karius, the microbial cell free DNA company, and Professor Emeritus of the Department of Pathology and Laboratory Medicine at the Medical University of South Carolina. He served as Vice-Chair for Laboratory Medicine/Medical Director of Clinical Laboratories and Molecular Pathology. He is a Diplomate of the American Board of Medical Microbiology and a Fellow of the American Academy of Microbiology. Dr. Nolte completed his B.S. degree in Biology at the University of Cincinnati, and his Ph.D. in Medical Microbiology at the Ohio State University. Dr. Nolte completed a postdoctoral fellowship in Public Health and Medical Laboratory Microbiology at the University of Rochester. Prior to coming to MUSC in 2007, he spent 18 years at Emory University School of Medicine where he was a Professor of Pathology and Laboratory Medicine and Director of the Clinical Microbiology, Molecular Diagnostic, and Serology Laboratories at Emory Medical Laboratories. He is active in and held positions of responsibility in the American Society for Microbiology, Association for Molecular Pathology, Clinical and Laboratory Standards Institute, Infectious Diseases Society of America, American Society for Clinical Pathology, College of American Pathology and American Association for Clinical Chemistry. He has authored numerous book chapters, practice guidelines, and peer-reviewed publications in the areas of clinical microbiology and molecular diagnostics.

Welcome to the podcast with Dr. Brendan McCarthy! In this episode we go over hormone lab values. They aren't just the simple ranges your doctor may be telling you you're in between. I'm here to tell you why they are so much more than that and why you should be getting yours done! Dr. Brendan McCarthy founded Protea Medical Center in 2002. While he's been the chief medical officer, Protea has grown and evolved into a dynamic medical center serving the Valley and Central Arizona. A nationally recognized as an expert in hormone replacement therapy, Dr McCarthy s the only instructor in the nation who teaches BioHRT on live patients. Physicians travel to Arizona to take his course and integrate it into their own practices. Besides hormone replacement therapy, Dr. McCarthy has spoken nationally and locally before physicians on topics such as weight loss, infertility, nutritional therapy and more. Thank you for tuning in and don't forget to hit that SUBSCRIBE button! Let us know in the COMMENTS if you have any questions or what you may want Dr. McCarthy to talk about next! Check out Dr. Brendan McCarthy's Book! https://www.amazon.com/Jump-Off-Mood-Swing-Hormones/dp/0999649604 --More Links-- Instagram: www.instagram.com/drbrendanmccarthy TikTok: www.tiktok.com/drbrendanmccarthy Clinic Website: www.protealife.com Sources: Utah Governor Huntsman recognizes medical laboratory week. Clinical Lab Products. Issue Stories. May 2006. http://www.clpmag.com/issues/articles/2006-05_03.asp. Boyd, James C. "Defining laboratory reference values and decision limits: populations, intervals, and interpretations." Asian journal of andrology 12.1 (2010): 83. Salvatore, Domenico, et al. "The relevance of T3 in the management of hypothyroidism." The Lancet Diabetes & Endocrinology (2022). Llamas, Michael, Maria Luisa Garo, and Luca Giovanella. "Low free-T3 serum levels and prognosis of COVID-19: systematic review and meta-analysis." Clinical Chemistry and Laboratory Medicine (CCLM) 59.12 (2021): 1906-1913. Whyte MB, Kelly P The normal range: it is not normal and it is not a range Postgraduate Medical Journal 2018;94:613-616..

Welcome to the podcast with Dr. Brendan McCarthy! In this episode we go over lab values for thyroid. Your body uses thyroid hormones to regulate all kinds of processes. That includes how fast you burn calories, your heart rate, and many other automatic functions. Lets take a look at what the proper levels should look like when it comes to Thyroid! Feel free to leave any questions you may have in the comments below! Dr. Brendan McCarthy founded Protea Medical Center in 2002. While he's been the chief medical officer, Protea has grown and evolved into a dynamic medical center serving the Valley and Central Arizona. A nationally recognized as an expert in hormone replacement therapy, Dr McCarthy s the only instructor in the nation who teaches BioHRT on live patients. Physicians travel to Arizona to take his course and integrate it into their own practices. Besides hormone replacement therapy, Dr. McCarthy has spoken nationally and locally before physicians on topics such as weight loss, infertility, nutritional therapy and more. Thank you for tuning in and don't forget to hit that SUBSCRIBE button! Let us know in the COMMENTS if you have any questions or what you may want Dr. McCarthy to talk about next! Check out Dr. Brendan McCarthy's Book! https://www.amazon.com/Jump-Off-Mood-Swing-Hormones/dp/0999649604 --More Links-- Instagram: www.instagram.com/drbrendanmccarthy TikTok: www.tiktok.com/drbrendanmccarthy Clinic Website: www.protealife.com #thyroid #thyroidproblems #thyroidhealing #thyroidawareness   Sources: Hollowell JG et al. J Clin Endocrinl Metab 2002 87(2)489-499 Bunevicius R et al. Effects of thyroxine as compared with thyroxine plus triiodothyronine in patients with hypothyroidism. N Engl J Med 1999 Feb 11;340(6):424-9 Biondi, B et al. Combination Treatment with T4 and T3: Toward Personalized Replacement Therapy in Hypothyroidism? JCEM July 2012, 97(7):2256-2271. Yamazaki, Yuko, et al. "Low free triiodothyronine level as a predictor of cardiovascular events and all-cause mortality in patients undergoing hemodialysis: the DREAM cohort." Journal of Atherosclerosis and Thrombosis 28.10 (2021): 1071-1082. Llamas, Michael, Maria Luisa Garo, and Luca Giovanella. "Low free-T3 serum levels and prognosis of COVID-19: systematic review and meta-analysis." Clinical Chemistry and Laboratory Medicine (CCLM) 59.12 (2021): 1906-1913. Plebani, Mario, and Luca Giovanella. "Reflex TSH strategy: the good, the bad and the ugly." Clinical Chemistry and Laboratory Medicine (CCLM) 58.1 (2019): 1-2 Robertson, R. Paul, ed. Degroot's Endocrinology: Basic Science and Clinical Practice. Elsevier Health Sciences, 2023

Mathilde TouvierSanté publique 2022-2023Collège de FranceColloque - Nutritional Determinants of Health: Recent Research Discoveries and Translation into Public Health Action : Nutritional Epidemiology of Chronic Diseases in the Omics EraIntervenant(s)Pr Frank Hu, Department of Nutrition, Harvard School of Public Health, Boston, Mass., USARésuméNutritional epidemiology plays a critical role in understanding the relationship between diet and risk of chronic diseases. With recent advances in omics technologies including genomics, metabolomics, proteomics, and metagenomics, there are new opportunities to explore biological mechanisms underlying diet, metabolic pathways, and health outcomes. In my presentation, I will discuss our efforts to incorporate omics technologies especially high throughput metabolomics into our large cohort studies including the Nurses' Health Study and Health Professionals' Follow-up Study as well as the PREDIMED trial. The integration of omics data in nutritional epidemiology holds great promises in identifying novel biomarkers for dietary intakes and predicting future disease risk. The repeated measures of diet enable us to examine long-term relationships between dietary factors and chronic disease risk and whether these associations are mediated or modified by individuals' metabolic profiles. These analyses have the potential to facilitate more effective precision or personalized nutrition interventions. Continued efforts and collaboration are necessary to fully leverage the potential of omics data in nutritional epidemiologic research and chronic disease prevention.Franck HuDr. Frank Hu is Chair of Department of Nutrition, Fredrick J. Stare Professor of Nutrition and Epidemiology at Harvard T.H. Chan School of Public Health and Professor of Medicine, Harvard Medical School and Brigham and Women's Hospital. Dr. Hu received his MD from Tongji Medical College in China and MPH and PhD in Epidemiology from University of Illinois at Chicago. He completed a postdoctoral fellowship in Nutritional Epidemiology at Harvard T.H. Chan School of Public Health. Dr. Hu's major research interests include epidemiology and prevention of cardiometabolic diseases through diet and lifestyle; gene-environment interactions; nutritional metabolomics; and nutrition transitions in low- and middle-income countries. Currently, he is Director of Boston Nutrition and Obesity Research Center Epidemiology and Genetics Core and Director of Dietary Biomarker Development Center at Harvard University. He has published a textbook on Obesity Epidemiology (Oxford University Press) and >1400 peer-reviewed papers with an H-index of 290. He served on the Institute of Medicine (IOM) Committee on Preventing the Global Epidemic of Cardiovascular Disease, the Obesity Guideline Expert Panel, American Heart Association Nutrition Committee, and the 2015 Dietary Guidelines Advisory Committee, USDA/HHS. He has served on the editorial boards of Lancet Diabetes & Endocrinology, Diabetes Care, and Clinical Chemistry. Dr. Hu was elected to the National Academy of Medicine in 2015.

Welcome to this special episode of Working With Startups from Science! In this episode, my guest is Dr. Laura Surace, a brilliant scientist and group leader at the University of Bonn in the department of Clinical Chemistry and Clinical Pharmacology. Dr. Surace and her lab are currently focusing on understanding how immune cells work in tumor development. But that's not all! Dr. Surace is also the founder of Naos communication, a science communication agency that helps scientists from around the world communicate their research results to a wider audience. As Dr. Surace says, "We bring science to people's homes." In this episode, I'm diving deep into Dr. Surace's work, career, and the reason why she founded her own company. Listeners can expect an insightful conversation about medicine, communication, and science entrepreneurship. So fasten your seatbelts and get ready to learn from this amazing scientist and entrepreneur! LAURA SURACE on LINKEDIN: https://www.linkedin.com/in/laura-surace-370197110/ CHECK OUT NAOS COMMUNICATION: https://www.naoscommunication.com CHECK OUT STARTUPS FROM SCIENCE: https://www.linkedin.com/company/startups-from-science/

Over the past decade, blood-based biomarkers for dementia have been increasingly studied as way to diagnose and track the progress of Alzheimer's and other neurodegenerative diseases. In this podcast three leading blood-based biomarker pioneers come together to discuss the field, their research and motivations, current challenges and future directions of this field of research (they also reveal a little about themselves as people away from the lab too – find out which if them wants to drive refuse trucks…). In the host chair is Dr Nicholas Ashton, Associate Professor of Neurochemistry from University of Gothenburg and King's College London. Nicks has more than a decade of experience in biofluid analysis and assay development for Alzheimer's disease, which ranges from discovery mass spectrometry methods to ultra-sensitive immunoassays. Recently this has produced ultra-sensitive single molecular array (Simoa) assays for phosphorylated tau in blood, which are now widely used in research settings, therapeutics trials and being validated for clinical use. -- Nick's guests are: Oskar Hansson, Professor of Neurology & Senior Consultant in Neurology at Lund University in Sweden. Oskar explores fluid and imaging biomarkers for neurodegenerative disorders. His inspiration came at medical school when diagnosing dementias. It became clear to him that we needed to be able to identify these diseases before widespread neurodegeneration and disabling symptoms have already developed. At these early disease stages, we are more likely to substantially slow down or even stop the disease progression by different types of interventions. Henrik Zetterberg, Professor of Neurochemistry, Senior Consultant in Clinical Chemistry, Head of Department at UK Dementia Research Institute at University College London and University of Gothenburg. With a background in molecular biology and medicine, Henrik has have spent the last 15 years developing biomarkers for Alzheimer's disease and other brain disorders - becoming a world expert in the process. He has published more than 1100 scientific articles and has received numerous awards. -- If you're listening to this podcast, you probably already know that Biomarkers are proteins, molecules, or other measurable substances that can provide valuable insight into diagnosing and measuring the progression of a medical condition or disease. For a many years researchers have been exploring the potential of what can discover from blood, to help diagnose Alzheimer's and other Neurodegenerative diseases. -- You can find out more about our panellists, and their work on our website. There you will also find a full transcript: https://www.dementiaresearcher.nihr.ac.uk -- Like what you hear? Please review, like, and share our podcast - and don't forget to subscribe to ensure you never miss an episode. -- This podcast is brought to you by University College London / UCLH NIHR Biomedical Research Centre in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia who we thank for their ongoing support.

As medicine continues to grow and evolve, so too does the field of laboratory medicine. Join Laborastories host Dr. Shannon Haymond as she speaks with Dr. Jason Park about his new role as the Editor of AACC's Clinical Chemistry Journal. He discusses the evolution of the journal, what he sees for the future, and how it can help support both experienced and new members of the profession. 

World Diabetes Day takes place each year in the month of November, created to raise awareness about the disease.  Diabetes is a global health threat diabetes with the number of people living with diabetes continuing to rise. Diagnostic testing is one of the major tools to help prevent and manage the disease.    About our Speaker: Dr. Amy L. Pyle earned her Ph.D. in Molecular Pathology from Vanderbilt University. Following graduate school, Dr. Pyle completed a post-doctoral fellowship in Clinical Chemistry at Vanderbilt University. Dr. Pyle took a position as Assistant Director of Core Laboratories at Nationwide Children's Hospital in 2011. Throughout her training, Dr. Pyle published multiple abstracts, papers, and book chapters, and has received numerous awards for her contributions to the scientific community.

Diabetes is an epidemic that we need to be addressing more.  It starts with whole food nutrition and exercise but an insulin supplement can also help reverse this disease. I had the pleasure to sit down with Dr. John Burd as we discuss our passions on this topic further.  In this episode John talks about:His background and his story getting into the world of diabetesPresentation of Lysulin and what it can do for Type 2 diabetesHow to order Lysulin and testing A1C at homeWhy creating a supplement at this time is important Explains what is in Lysulin that makes it so effectiveAnd so much moreJohn's Bio: Dr. John Burd has authored over 40 publications and holds 35 patents. He graduated from Purdue University with a B.S. in Biochemistry, and earned an M.S. and Ph.D., in Biochemistry from the University of Wisconsin. In 2010, he was inducted into the American Association of Clinical Chemistry Hall of Fame and received the Ullman Prize for Innovation in Clinical Chemistry.Dr. Burd  was the Founder & CEO of Lysulin, Inc, a diabetes managemewnt company.  Lysulin launched an all-natural, scientifically proven, nutraceutical product proven to improve the health of people with diabetes in Jnaury 2018. Before Lysulin, he was President & CEO of DexCom, which is now the leader in glucose monitoring for diabetics. Prior to DexCom, he was a General Partner of Windamere Venture Partners.  In 2019 he founded Wonder Spray, llc to bring an amazing natural product to people who needed it.  Wonder Spray is EPA registered for COVID-19 disinfection and is useful for a long list of ailments.Guest's links:Website: https://www.lysulin.comEmail: jburd@jfburd.comPhone # 619-992-2873Host's links: Website: https://www.elizabethdicristofano.comEmail me at info@elizabethdicristofano.comInstagram: https://www.instagram.com/healthy_achievherPodcast Survey for a free $25 US Amazon Gift Card https://bit.ly/rootofourhealthsurveySupport the show

Today's podcast explores the history of diagnosing diabetes and provides an overview of prediabetes. Listen and learn!

Leanne O'Connor is a Biomedical Scientist in Clinical Biochemistry at Western Health and Social Care Trust, Enniskillen, UK.Gareth McKeeman is Consultant Clinical Scientist at Belfast Health and Social Care Trust, Belfast, UK.

Karen has travelled from Dublin to Toronto to London to meet with people who have worked tirelessly to find new ways of treating children with sensory difficulties.Dr. William Shaw, PhD, is an American chemist, autism researcher and the founder and director of the Great Plains Laboratory, based in Lenexa, Kansas. William Shaw, is board certified in the fields of clinical chemistry and toxicology by the American Board of Clinical Chemistry. Before he founded The Great Plains Laboratory, Inc., Dr. Shaw worked for the Centers for Disease Control and Prevention (CDC), Children's Mercy Hospital, University of Missouri at Kansas City School of Medicine, and Smith Kline Laboratories. He is the author of Biological Treatments for Autism and PDD, originally published in 1998 and Autism: Beyond the Basics, published in 2009. He is also a frequent speaker at conferences worldwide. Our GDPR privacy policy was updated on August 8, 2022. Visit acast.com/privacy for more information.

The LabOpp Global Leaders podcast is a series of conversations about Careers, the Lab Industry, Training, and People. In this episode, I was pleased to be joined by Itai Chitungo from Zimbabwe. Itai is a lecturer at the University of Zimbabwe but that is truly just the tip of the iceberg. He is heavily engaged in trying to foster growth within the field to fill gaps left by decades of a painful brain drain. He is an active mentor to many students, who under his guidance and support has not only remained in Zimbabwe but thrived there. Itai shares his recent research on Telemedicine in Africa, an overview of the laboratory services and health care system in Zimbabwe, and his advice for the next generation looking to enter the field. If you would like to get in touch with Itai Chitungo, you can find him on LinkedIn Some of the organizations mentioned during this podcast: · University of Zimbabwe https://www.uz.ac.zw/ · International Federation of Clinical Chemistry https://www.ifcc.org/ If you have suggestions for future guests or comments about this podcast, please visit us at labopp.org/podcast --- Send in a voice message: https://podcasters.spotify.com/pod/show/labopp/message

Corinne Gasper's daughter was killed by a medical marijuana-impaired driver, listen to this important podcast with  Marilyn A. Huestis, Ph.D. Clinical Pharmacology and Toxicology, Cannabinoid Pharmacotherapies Expertise, as they discuss the science of marijuana-impaired driving. Professor Dr. (h.c.) Marilyn A. Huestis recently retired as Chief, Chemistry and Drug Metabolism, National Institute on Drug Abuse, National Institutes of Health, after 23 years of conducting controlled drug administration studies. Currently, she is Senior Fellow, Institute on Emerging Health Professions, Thomas Jefferson University, Philadelphia, PA, Senior Scientific Advisor to PinneyAssociates and President of Huestis & Smith Toxicology, LLC. Her research program focuses on discovering mechanisms of action of cannabinoid agonists and antagonists, effects of in utero drug exposure, oral fluid testing, driving under the influence of drugs, and the neurobiology and pharmacokinetics of novel psychoactive substances leading to 529 peer-reviewed manuscripts. Professor Huestis received a Doctor Honoris Causa from the Faculty of Medicine, the University of Helsinki in Finland in 2010 and received many other important awards in toxicology, clinical chemistry, public safety, drug dependence, and addiction, and scientific research. The journal Clinical Chemistry featured her as an “Inspiring Mind”. She currently serves on the Organization of Scientific Area Committee on Toxicology, World Anti-doping Agency's Prohibited List Committee, and the National Safety Council's Alcohol, Drugs and Impairment Division Executive Board. Professor Huestis served on the National Commission on Forensic Sciences. She is past president of the Society of Forensic Toxicologists, past Chair of the Toxicology Section of the American Academy of Forensic Sciences, and past president of The International Association of Forensic Toxicologists.Corinne is director of Jennifer's Messengers, an organization to educate about the dangers of marijuana-drugged driving and to honor her daughter and other people killed by marijuana-impaired driving.Please join Every Brain Matters to support Jennifer's Messengers and raise awareness about DUID.Make a donation and receive Jennifer's Messengers Car Kit, as a reminder to drive sober and to bring awareness to marijuana driving dangers.Support our podcast on Patreon the show (https://www.patreon.com/everybrainmatters)Support the show (https://www.patreon.com/everybrainmatters)

Testing remains one of the most confusing elements of the pandemic for many people. In this Toolkit, Andy talks to diagnostics expert Mara Aspinall and immunologist Gigi Gronvall to answer your questions about rapid antigen tests – when people should get tested, how accurate they are, why they're in short supply, and much more.   Keep up with Andy on Twitter @ASlavitt and Instagram @andyslavitt.    Follow Mara @MaraAspinall and Gigi @ggronvall on Twitter.   Joining Lemonada Premium is a great way to support our show and get bonus content. Subscribe today at bit.ly/lemonadapremium.    Support the show by checking out our sponsors!   Click this link for a list of current sponsors and discount codes for this show and all Lemonada shows: https://lemonadamedia.com/sponsors/  Throughout the pandemic, CVS Health has been there, bringing quality, affordable health care closer to home—so it's never out of reach for anyone. 

Learn more at cvshealth.com.   Check out these resources from today's episode:  Check out the CDC's Interim Guidance for Antigen Testing for SARS-CoV-2: https://www.cdc.gov/coronavirus/2019-ncov/lab/resources/antigen-tests-guidelines.html Read Gigi's Clinical Chemistry article titled “COVID-19 Testing and a Path out of the Pandemic”: https://academic.oup.com/clinchem/advance-article/doi/10.1093/clinchem/hvab226/6382305?guestAccessKey=42b74d06-49a8-4972-9183-7583cd3edbc1 Watch a video of how to take an at-home test, as Gigi suggests, before administering one on yourself: https://www.webmd.com/coronavirus-in-context/video/covid-home-testing Find a COVID-19 vaccine site near you: https://www.vaccines.gov/  Order Andy's book, Preventable: The Inside Story of How Leadership Failures, Politics, and Selfishness Doomed the U.S. Coronavirus Response: https://us.macmillan.com/books/9781250770165    Stay up to date with us on Twitter, Facebook, and Instagram at @LemonadaMedia.    For additional resources, information, and a transcript of the episode, visit lemonadamedia.com/show/inthebubble. See omnystudio.com/listener for privacy information.

Dr. Alana Ogata, Ph.D. is an Assistant Professor jointly appointed in the Department of Chemistry and Department of Chemical and Physical Sciences at the University of Toronto Mississauga (UTM). Throughout her academic career, she has received seven fellowships and published 19 papers in high-impact journals, such as NanoLetters and JACS, providing important contributions to the fields of electrochemical biosensors, non-classical nucleation and growth, and disease diagnostics. As an NSF Graduate Research Fellow under Dr. Reg Penner at UC Irvine, she developed a new electrochemical biosensor named the virus bioresistor (VBR), capable of label-free and rapid protein detection for point-of-care applications. During a four-month NSF GROW fellowship in South Korea, Dr. Ogata fabricated highly-porous carbon nanofibers via electrospinning and integrated the nanofibers with the VBR platform to develop a tear-based glucose sensor, as described in Analytical Chemistry. In her six-month postdoctoral position with Dr. Joe Patterson at UC-Irvine, I learned and executed cryotransmission electron microscopy (cryoTEM) to study the formation of protein-metal-organic-framework (p-MOF) composites, earning a front-cover featured publication in JACS. As an NIH T32 postdoctoral fellow at the Brigham and Women's Hospital, she led a project on the detection of COVID-19 viral antigens in collaboration with researchers at Dana Farber Cancer Institute and Massachusetts General Hospital. Within a six-month period, she co-wrote and received a grant for COVID-19 research, developed ultrasensitive viral antigen assays, tested COVID-19 patient samples, and published two manuscripts – one as first author in Clinical Chemistry. In addition, Dr. Ogata initiated and executed a study on vaccinated participants and led the design of sample collection, assay development, and sample analysis in collaboration with researchers at the Brigham and Women's Hospital. This study resulted in a first author publication in Clinical Infectious Diseases, and presents the first evidence of SARS-CoV-2 protein production from mRNA vaccination. Outside of lab, she enjoys working out and enjoying happy hour with friends. You can follow Dr. Ogata on Twitter @OgataAlana. Link to Dr. Ogata's Faculty Research Page: https://www.utm.utoronto.ca/cps/people/alana-ogata Prof. Ogata's Favorites: Favorite Workout Song: "Get Me Bodied - (Move Your Body rework)" by Beyonce Favorite snacks: Popcorn and a matcha latte Favorite places to visit in Canada: Downtown Toronto, visiting the fun bars, fun restaurants What's on her Watchlist?: Modern Family; The Chair Chemistea is a chemistry and science podcast founded by Lucy Yang (she/her), currently a fourth-year undergraduate at UC Irvine, studying chemistry and biological sciences. Some of the most famous scientific collaborations and discoveries were born from a conversation over tea, and on her podcast, Lucy aims to combine her love of talking with her love of sharing and hearing stories—stories about others' passion for science, their journeys, and any and all fun shenanigans in between. You can follow Lucy on twitter @isolucyine. She is also the founder of The Kawaii Chemist, a shop where you can find cute chemistry stickers and merch, where 100% of profit goes to charity. You can check out The Kawaii Chemist here, and you can donate to support Kawaii Chemist and the Chemistea podcast here. Thank you listening!

Timestamps:00:00 Intro01:00 Can you give us the lay of the land and explain how does the cardiovascular laboratory provide patient care?03:24 Can you elaborate for us what it looks like when you have clinical chemists, cardiologists, and other professionals with different backgrounds working together?05:56 Can you talk about bringing these people into the laboratory and developing a test that provides a lot of value to patients? How is that blended and what’s the output?07:31 Talking about meetings that you guys do -- how is this meeting not some hierarchy of people who come together? How do these meetings work as an interprofessional utopia?   11:21 How do you keep your clinical colleagues educated about laboratory science?14:25 Are other laboratories adopting this leadership model?15:42 What have you learned about establishing the culture and getting them to understand what the plan is?17:59 Turning to medical laboratory scientists, what’s your pitch for why they should go into clinical chemistry? 20:12 Outro 

Season 2 Episode 4: The Prince of Poisoners, Dr. William Palmer, meets his match in Albert Swaine Taylor. Cheers! Old Timey Crimey: https://open.spotify.com/show/5RT0RA9i9kV7ldhWu04FcU?si=DiD_SV7ETwuo2ef77bV5Zg Short Story, Short Podcast: https://open.spotify.com/show/3q2moJE65wLBf0zFjqhMhu?si=3zbTwhkIQnOYVqbd_TmZYQ Come chat with me on Twitter, FB, or Instagram! Sources Dave Lewis. “William Palmer: the infamous Rugely Poisoiner.” http://staffscc.net/wppalmer/ Office for National Statistics. ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/lifeexpectancies/articles/howhaslifeexpectancychangedovertime/2015-09-09 Kenneth Gibson. “Killer Doctors: The ultimate betrayal of trust.” Winnipeg Free Press. Tom Oleson. https://newspaperarchive.com/winnipeg-free-press-oct-25-1969-p-17/ https://murderpedia.org/male.P/p/palmer-william.htm Rose Stavely-Wadham. British Newspaper Archive Blog https://blog.britishnewspaperarchive.co.uk/2020/03/25/william-palmer-the-rugeley-poisoner/ N.G. Coley. Medical History. Nat’l library of medicine. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1036419/pdf/medhist00049-0027.pdf L. Rosenfeld. Clinical Chemistry. https://academic.oup.com/clinchem/article-abstract/31/7/1235/5651875 Corinne Hogan. Royal College of Surgeons of England. https://www.rcseng.ac.uk/library-and-publications/library/blog/alfred-swaine-taylor/ Music Plans in Motion by Kevin MacLeod Link: https://incompetech.filmmusic.io/song/4225-plans-in-motion FamilialCrises by Lilo Sound Link: https://filmmusic.io/song/6536-familialcrises Comic Plodding by Kevin MacLeod Link: https://filmmusic.io/song/3533-comic-plodding Prelude in C (BWV 846) by Kevin MacLeod Link: https://incompetech.filmmusic.io/song/4237-prelude-in-c-bwv-846- Laendler in C Minor (Hess 68) by Kevin MacLeod Link: https://incompetech.filmmusic.io/song/3961-laendler-in-c-minor-hess-68- Mysterious Fear by MusicLFiles Link: https://filmmusic.io/song/7108-mysterious-fear Inspiring Chopin Nocturne by MusicLFiles Link: https://filmmusic.io/song/6937-inspiring-chopin-nocturne TheTutor by Lilo Sound Link: https://filmmusic.io/song/6938-thetutor Licenses for all music: http://creativecommons.org/licenses/by/4.0/

My guest today is Dr Barbarajean Magnani.  Dr Magnani is a Pathologist and Toxicologist, and is the author of The Queen of All Poisons.What we discuss with Dr Magnani:Her work as a toxicology consultant and as Pathologist in Chief at Tufts University School of MedicineHow her Master's degree in Marine Environmental Science led to her interest in toxinsHow a series of stories she wrote for the Journal of Clinical Chemistry became Lily Robinson and the Art of Secret PoisoningThe inspiration for the character Dr Lily RobinsonHow Michael Crichton had an influence on her writingThe visible pathologist and how Lily Robinson portrays thisThe sequel to The Queen of All Poisons, called The Power of Poison, to be released in March 2021Links for this episode:Dr Magnani:WebsiteTwitterThe Queen of All Poisons from AmazonEncircle PublicationsThe Art of Secret Poisoning from AACC People of Pathology Podcast:WebsiteTwitter

For pathologists and laboratory professionals in academia, publishing research in peer-reviewed literature is critical to success. And beyond that, there is a sense of fulfillment that comes from contributing to scientific knowledge and furthering the progress of society. On this episode of Inside the Lab, our hosts Dr. Lotte Mulder and Ms. Kelly Swails are joined by Dr. Steven Kroft, MD, MASCP, Editor in Chief of the American Journal of Clinical Pathology, Dr. Roger Bertholf, PhD, DABCC, FAACC, Medical Director of Clinical Chemistry at Houston Methodist Hospital and Editor in Chief of Laboratory Medicine, and Dr. Sanjay Mukhopadyay, MD, Director of Pulmonary Pathology at the Cleveland Clinic and Associate Editor of the American Journal of Clinical Pathology, to explain why research and publication are important to a career in laboratory medicine. The panelists weigh in on the peer review process, describing what it is, how it works, why it’s important—and how it’s been fast-tracked in the season of COVID. Listen in for insight on sharing research findings on social media and learn how to maximize your chances of getting published in a scientific journal. Key Takeaways · The importance of research to an academic career in laboratory medicine and how publication serves as a form of scientific communication· Separating scientific literature from unvetted information· What the peer review process looks like and how it improves healthcare practice and delivery· The editor’s responsibility and limitations for a publication’s integrity · The disadvantages of the peer review process· Sharing research findings on social media, and informal post-publication reviews· The increase in submissions to scientific journals during the pandemic, and how editors are responding· How to maximize your chances of getting published Connect with ASCP ASCPASCP on FacebookASCP on InstagramASCP on Twitter Connect with Dr. Kroft American Journal of Clinical PathologyDr. Kroft on Twitter Connect with Dr. Bertholf Laboratory MedicineDr. Bertholf at Houston MethodistDr. Bertholf on Twitter Connect with Dr. MukhopadhyayAmerican Journal of Clinical PathologyDr. Mukhopadhyay at the Cleveland ClinicDr. Mukhopadhyay on Twitter Connect with Dr. Mulder & Ms. SwailsDr. Mulder on TwitterMs. Swails on Twitter

Your favourite medical science podcast is making the most of ‘the new normal’ - this year’s Raw Talk Live event was broadcast entirely on YouTube! Over 8 weeks, we spoke to researchers all across Canada about all things COVID-19. Our 6th instalment focuses on COVID-19 testing – what the tests tell us and how they work, how testing has changed the course of the pandemic, and what we can expect from them in terms of epidemiological surveillance and recovery as we move forward. Dr. Adeli is a senior scientist and clinical biochemist with over 30 years of experience in clinical chemistry service, education, and research. He is currently the Head of Clinical Biochemistry at the Hospital for Sick Children and Full Professor in the Departments of Laboratory Medicine and Pathobiology, Biochemistry, and Physiology at the University of Toronto. Dr. Adeli also serves as the President of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) and the current Editor-in-Chief of Critical Reviews in Clinical Laboratory Sciences. Mary Kathryn Bohn is a PhD candidate in the Department of Laboratory Medicine and Pathobiology at the University of Toronto. She earned her Bachelor’s degree in Biochemistry at McMaster University in 2018 and is now a trainee with the Canadian Laboratory Initiative on Paediatric Reference Intervals (CALIPER) under the supervision of Dr. Khosrow Adeli at The Hospital for Sick Children. Guest - Dr Khosrow Adeli Guest - Mary Kathryn Bohn Watch this stream on YouTube U of T Alumni Offers from our sponsors TD Insurance & MBNA COVID Decoded Feedback survey

Your favourite medical science podcast is making the most of ‘the new normal’ - this year’s Raw Talk Live event was broadcast entirely on YouTube! Over 8 weeks, we spoke to researchers all across Canada about all things COVID-19. Our 6th instalment focuses on COVID-19 testing – what the tests tell us and how they work, how testing has changed the course of the pandemic, and what we can expect from them in terms of epidemiological surveillance and recovery as we move forward. Dr. Adeli is a senior scientist and clinical biochemist with over 30 years of experience in clinical chemistry service, education, and research. He is currently the Head of Clinical Biochemistry at the Hospital for Sick Children and Full Professor in the Departments of Laboratory Medicine and Pathobiology, Biochemistry, and Physiology at the University of Toronto. Dr. Adeli also serves as the President of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) and the current Editor-in-Chief of Critical Reviews in Clinical Laboratory Sciences. Mary Kathryn Bohn is a PhD candidate in the Department of Laboratory Medicine and Pathobiology at the University of Toronto. She earned her Bachelor’s degree in Biochemistry at McMaster University in 2018 and is now a trainee with the Canadian Laboratory Initiative on Paediatric Reference Intervals (CALIPER) under the supervision of Dr. Khosrow Adeli at The Hospital for Sick Children. Guest - Dr Khosrow Adeli Guest - Mary Kathryn Bohn Watch this stream on YouTube U of T Alumni Offers from our sponsors TD Insurance & MBNA COVID Decoded Feedback survey

Retornamos com o TdC Lab, dessa vez para falar sobre Troponina! Raphael, João e Guilherme Moura falam desse exame precioso na sala de emergência. Quer fazer alguma sugestão ou critica? Entra em contato com a gente através do e-mail tadeclinicagem@gmail.com ou pelo Instagram @tadeclinicagem MINUTAGEM (2:46) o que é troponina? (4:27) Valor de referência (7:22) Troponina ultra sensível (10:10) o que faz q troponina subir (11:50) injúria miocárdica (16:30) Tipo de infartos (18:15) Injúria miocárdica x infarto do tipo II (20:20) Troponina acima do p99 mas que não curva (20:45) Fatores que aumentam a troponina (21:17) cinética da troponina (22:58) Valor prognóstico (23:38) Escore de Heart (25:05) Quando não pedir (27:26) Resumo (28:31) CKMB (29:28) salves (30:46) Resposta do desafio anterior (32:00) Desafio da semana REFERÊNCIAS 1- UPTODATE Jul 2020. Troponin testing: Analytical considerations. Allan S Jaffe, David A Morrow, Juan Carlos Kaski 2- FDA Warns that Biotin may interfere with Lab Tests: FDA Safety Communication ( https://www.fda.gov/medical-devices/safety-communications/update-fda-warns-biotin-may-interfere-lab-tests-fda-safety-communication) 3- UPTODATE JUL 2020. Troponin testing: Clinical Use. Allan S Jaffe, David A Morrow, Juan Carlos Kaski, Gordon Saperia. 4- THYGESEN, Kristian et al. Fourth universal definition of myocardial infarction (2018). Journal of the American College of Cardiology, v. 72, n. 18, p. 2231-2264, 2018. mn 5- WANG, Alfred Z. et al. Troponin Testing and Coronary Syndrome in Geriatric Patients With Nonspecific Complaints: Are We Overtesting?. Academic Emergency Medicine, v. 27, n. 1, p. 6-14, 2020. 6- WU, Alan HB et al. Clinical laboratory practice recommendations for the use of cardiac troponin in acute coronary syndrome: expert opinion from the Academy of the American Association for Clinical Chemistry and the Task Force on Clinical Applications of Cardiac Bio-Markers of the International Federation of Clinical Chemistry and Laboratory Medicine. Clinical chemistry, v. 64, n. 4, p. 645-655, 2018. 7. Site com valores de referência da Troponina. http://www.ifcc.org/executive-board-and-council/eb-task-forces/task-force-on-clinical-applications-of-cardiac-bio-markers-tf-cb.

In this episode, Drs. Steven Lowes and Barry Jones discuss hybrid assays, combining immuno-affinity with liquid chromatography-mass spectrometry (LC-MS). This is a growing area of opportunity for protein bioanalysis. Topics covered include: What is meant by hybrid assay Reasons to choose a hybrid assay Top down vs bottom up Specific challenges Assay design considerations Future potential for this type of bioanalysis ...I think that fundamental point about more sensitivity, and associated with that is more selectivity, is going to be part of the future adoption of these hybrid assays. We have needs already, we can see needs for looking at quantifying proteins in very small samples, say tissue biopsies. - Steven Lowes Learn more at Q2labsolutions.com. Protein Biomarker Quantification by Immunoaffinity Liquid Chromatography–Tandem Mass Spectrometry: Current State and Future Vision (Article in Clinical Chemistry)

On this week's The Sci-Files, your hosts Chelsie and Danny interview Abdulrahman Alharthi, Erin Sawyer, and Kaylie Williams.Abdulrahman, Erin, and Kaylie are all undergraduates at MSU and work as research assistants in Dr. Kimberly Fenn's Sleep and Learning Lab. Abdulrahman Alharthi is a 4th-year undergraduate student majoring in Biomedical Laboratory Science with a concentration in Clinical Chemistry and minor in Leadership in Integrated Learning. Erin Sawyer is a 2nd-year undergraduate student and Alumni Distinguished scholar in the Honors College studying Psychology and Data Science, with minors in Social Science Quantitative Data Analysis and Japanese. Kaylie Williams is a 4th-year undergraduate student pursuing a major in Psychology with minors in Health Promotion and Cognitive Science. This work was conducted under the direction of Elle Wernette, a 4th-year graduate student. In this episode, the three undergraduates discuss a line of research that focuses on the relationship between sleep and memory. After memories are first formed, or encoded, they remain in a vulnerable state, subject to decay or distortion. Consolidation processes help strengthen memories against these vulnerabilities, and some of these processes take place during sleep. Prior research has shown that sleep, specifically slow-wave sleep, consolidates memory for information that is actively studied, or intentionally encoded. They recently found that sleep also consolidates some memories that are incidentally encoded, which are memories that are formed when an individual works with but does not actively try to remember information. Their data suggested that the extent to which memory is consolidated during sleep may be based on the strength of the memory traces. To further explore this, they investigated the hypothesis that sleep consolidates strong, but not weak, memories after incidental encoding. They also sought to determine which components of sleep contribute to this mnemonic benefit.  These results give us insight into the relationship between sleep and memory consolidation, showing that sleep may consolidate more information than was previously thought. Sleep not only helps us remember the information we are intentionally trying to remember, but also seems to help us remember useful information that we encounter in passing.If you're interested in talking about your MSU research on the radio or nominating a student, please email Chelsie and Danny at scifiles@impact89fm.org. You can ask questions about future episodes here. Check The Sci-Files out on Twitter, Facebook, Instagram, and YouTube! 

A five-part special relay podcast series, where the interviewee becomes the interviewer. With five leading researchers discussing their research, their field, and the work of the Alzheimer’s Association ISTAART Professional Interest Area they represent. Part Two - Professor Henrik Zetterberg interviews Dr Prashanthi Vemuri Henrik Zetterberg is Professor of Neurochemistry, Senior Consultant in Clinical Chemistry and Head of Department at The Sahlgrenska Academy within the University of Gothenburg, Sweden, and University College London, UK. Henrik’s work is focused on Fluid biomarkers for neurodegenerative dementias. He is representing the Biofluid-based biomarkers PIA. Dr Prashanthi Vemuri is Associate Professor of Radiology at The Mayo Clinic College of Medicine and Science, Rochester, USA. Prashanthi’s research is focused on imaging biomarkers of Neurodegenerative and Cerebrovascular Disease. She is representing the Reserve, Resilience, and Protective Factors PIA. ______________________________________________ This podcast series is brought to you by Dementia Researcher. You can find out more about our panellists, and their work on our website www.dementiaresearcher.nihr.ac.uk. A transcript of this podcast is also available here https://www.dementiaresearcher.nihr.ac.uk/podcasts ______________________________________________ The Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) convenes the global Alzheimer's and dementia science community. Members share knowledge, fuel collaboration and advance research to find more effective ways to detect, treat and prevent Alzheimer's and other dementias. Professional Interest Areas (PIA) are an assembly of ISTAART members with common subspecialties or interests. There are currently 25 PIA covering a wide range of interests and fields, from the Alliance of Women Alzheimer's Researchers (AWARE) PIA to Biofluid Based Biomarkers and everything in between. To sign-up to ISTAART and a PIA visit www.alz.org/istaart/ ______________________________________________ Throughout July 2020, Dementia Researcher is giving you a chance to win a pair of Beats Studio Headphones. To be in with a chance to win, complete three east steps: 1. Leave us a review on iTunes 2. Register and attend one of our webinars 3. Register on our website. Winner will be chosen at random on the 1st August, and announced via Twitter follow-us @Dem_Researcher For more information visit www.dementiaresearcher.nihr.ac.uk ______________________________________________ Finally, the views and opinions expressed by guests in this podcast represent those of the guests and do not necessarily reflect those of NIHR Dementia Researchers, PIA membership, ISTAART or the Alzheimer's Association.

A five-part special relay podcast series, where the interviewee becomes the interviewer. With five leading researchers discussing their research, their field, and the work of the Alzheimer’s Association ISTAART Professional Interest Area they represent. Part One - Professor David Scott interviews Professor Henrik Zetterberg David Scott is Director of the Department of Anaesthesia and Acute Pain Medicine, St. Vincent’s Hospital Melbourne and Professor, School of Medicine, University of Melbourne, Australia. David is researches Perioperative Neurocognitive Disorders – in particular, delirium and cognitive decline associated with anaesthesia and surgery. He is representing the Perioperative Cognition and Delirium PIA. Henrik Zetterberg is Professor of Neurochemistry, Senior Consultant in Clinical Chemistry and Head of Department at The Sahlgrenska Academy within the University of Gothenburg, Sweden, and University College London, UK. Henrik’s work is focused on Fluid biomarkers for neurodegenerative dementias. He is representing the Biofluid-based biomarkers PIA. ______________________________________________ This podcast series is brought to you by Dementia Researcher. You can find out more about our panellists, and their work on our website www.dementiaresearcher.nihr.ac.uk. A transcript of this podcast is also available here https://www.dementiaresearcher.nihr.ac.uk/podcasts ______________________________________________ The Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) convenes the global Alzheimer's and dementia science community. Members share knowledge, fuel collaboration and advance research to find more effective ways to detect, treat and prevent Alzheimer's and other dementias. Professional Interest Areas (PIA) are an assembly of ISTAART members with common subspecialties or interests. There are currently 25 PIA covering a wide range of interests and fields, from the Alliance of Women Alzheimer's Researchers (AWARE) PIA to Biofluid Based Biomarkers and everything in between. To sign-up to ISTAART and a PIA visit www.alz.org/istaart/ ______________________________________________ Throughout July 2020, Dementia Researcher is giving you a chance to win a pair of Beats Studio Headphones. To be in with a chance to win, complete three east steps: 1. Leave us a review on iTunes 2. Register and attend one of our webinars 3. Register on our website. Winner will be chosen at random on the 1st August, and announced via Twitter follow-us @Dem_Researcher For more information visit www.dementiaresearcher.nihr.ac.uk ______________________________________________ Finally, the views and opinions expressed by guests in this podcast represent those of the guests and do not necessarily reflect those of NIHR Dementia Researchers, PIA membership, ISTAART or the Alzheimer's Association.

Molecular diagnostics is now firmly rooted in laboratory medicine and the January 2020 issue of Clinical Chemistry is devoted to this topic.  In that issue, Dr. Linnea Baudhuin reviews genome and exome sequencing as they’re used in clinical practice.

Molecular Diagnostics is clearly going from strength to strength.  That’s the title of the lead article by the guest editors in the January 2020 issue of Clinical Chemistry that is devoted to this topic.  It has been five years since the last molecular diagnostics theme issue was published in Clinical Chemistry.  In this new edition of the theme issue, the editors have highlighted some of the most exciting developments in the field including the maturation of massively parallel DNA sequencing technology allowing production of genomic data at the hospital or even population level. Joining us in this podcast is one of the guest editors for this special issue, Dr. Carl Wittwer. 

Molecular diagnostics is now firmly entrenched in laboratory medicine and the January 2020 issue of Clinical Chemistry is devoted to this topic.  In that issue is a case report that presents an unconventional diagnosis based somatic findings through germline whole-exome sequencing.  Joining us in this podcast is the lead author of that case report, Dr. Jaime Lopes, who is currently a fellow at the Genomics Laboratory in the Department of Laboratory Medicine and Pathology at the Mayo Clinic in Rochester, Minnesota. 

Breakthroughs in sequencing technology and computational biology have provided the basis for studies of the myriad ways in which microbial communities in and on the human body influence human health and disease. In almost every medical specialty, there is now growing interest in accurate and replicable profiling of the microbiome for use in diagnostic and therapeutic application.           In the January 2020 issue of Clinical Chemistry, which is devoted to topics in molecular diagnostics, Dr. Robert Schlaberg reviews microbiome diagnostics.

Molecular diagnostics is the topic of the January 2020 special issue of Clinical Chemistry.  In that issue, there is a counter point report on the use of circulating tumor cells in the management of cancer patients.  To provide further insight on this topic, we’re joined in this podcast by one of the editors of this special issue, Professor Klaus Pantel, Chairman of the Institute of Tumor Biology at the University Medical Center in Hamburg-Eppendorf in Germany. 

Maintaining high ethical standards is a characteristic we expect in many professionals, but perhaps most in the field of medicine.  Although biomedical ethics is a relatively new field, there have been discussions of moral issues in medicine since ancient times.  The Hippocratic Oath, for instance, was written by Hippocrates at approximately 400 B.C.  It requires that a new physician swear to uphold specific ethical standards.  Over 2000 years later new physicians still swear by the Hippocratic or a similar oath. The December 2019 issue of Clinical Chemistry published a Review paper that provides a broad overview of ethics as it pertains to laboratory medicine.

Measure Brain Toxins For Multiple Recovery SolutionsAn expert is someone who has succeeded in making decisions and judgements simpler through knowing what to pay attention to and what to ignore.~ Edward deBonoWilliam Shaw, Ph.D., is board certified in the fields of clinical chemistry and toxicology by the American Board of Clinical Chemistry - with a profound interest in brain toxins. Before he founded https://www.greatplainslaboratory.com (The Great Plains Laboratory), Inc. in Lenexa, KS, Dr. Shaw worked for the Centers for Disease Control and Prevention (CDC), Children's Mercy Hospital, the University of Missouri at Kansas City School of Medicine, and Smith Kline Laboratories. I've followed his work for many years, use Great Plains Laboratory for http://corebrainjournal.com/testing (biomedical testing) every day in my practice, and am exceedingly pleased to share these moments with his profound experience for our CBJ listeners. Recently Dr. Shaw added https://www.greatplainslaboratory.com/gpl-tox/ (GPL-TOX) to measure brain toxins to the Great Plains Labs armamentarium of essential mind tools. This CBJ Special 1-hour review will help listeners understand this possible next step for treatment failure globally. Ed Note: Take a moment to download Dr. Shaw's Bonus Notes below ↓ with many brain toxin reference topics for further review on this essential measurement tool. This is a republication of Dr. Shaw's exceedingly popular original interview at http://corebrainjournal.com/125 (CBJ/125) - to wrap up our New Year's Holiday Series with the CBJ Best of '17. Dr. Shaw's Years of Scholarship AchievementsIt's important to note that he is the author of two outstanding contributions to the evolution for the treatment of Autism, http://geni.us/shaw (Biological Treatments for Autism and PDD), originally published in 1998, and http://geni.us/shaw2 (Autism: Beyond the Basics), published in 2009. He is also a frequent speaker at conferences worldwide, a global authority with broad experience with the value of laboratory data and molecular insights regarding imbalanced brain functions. Personal NotesOn a more personal note, Dr. Shaw is the stepfather of a child with autism and has helped thousands of patients and medical practitioners to successfully improve the lives of people with autism spectrum disorders, ADHD/Executive Function, Alzheimer's disease, arthritis, bipolar disorder, chronic fatigue, depression, fibromyalgia, immune deficiencies, multiple sclerosis, OCD, Parkinson's disease, seizure disorders, tic disorders, Tourette's syndrome, and other serious conditions. References here demonstrate the depth of his understanding and life's mission. In this interview, we discuss useful details regarding the evolution and immediate value of measurements for brain toxins about many of these conditions. Dr. Shaw's Brain Toxins | Insights Detailed Here - CBJ/182GPL-TOX fulfills my lifetime wish to make toxin testing available for the public [spp-timestamp time="4:49"] 90% of the people don't know specific toxin exposure and could spend $20,000 searching [spp-timestamp time="6:00"] GPL-TOX tests for 172 different chemicals at about $200 [spp-timestamp time="6:42"] What high values on GPL-TOX testing mean medically [spp-timestamp time="7:49"] My first clinical case awareness on the relevance of brain toxins [spp-timestamp time="10:11"] Carbon Monoxide can cause kleptomania and death [spp-timestamp time="12:50"] One of the easiest things to remember about toxins [spp-timestamp time="13:22"] Humans are the most vulnerable to brain toxins and psych problems [spp-timestamp time="14:14"] Most common way they cause brain deterioration is through mitochondria [spp-timestamp time="15:52"] If you're waiting for the government to monitor toxins you might as well wait for the tooth fairy [spp-timestamp time="20:20"] The public must know: toxins cause a wide variety of mind/medical problems...

Measure Brain Toxins For Multiple Recovery SolutionsAn expert is someone who has succeeded in making decisions and judgements simpler through knowing what to pay attention to and what to ignore.~ Edward deBonoWilliam Shaw, Ph.D., is board certified in the fields of clinical chemistry and toxicology by the American Board of Clinical Chemistry - with a profound interest in brain toxins. Before he founded https://www.greatplainslaboratory.com (The Great Plains Laboratory), Inc. in Lenexa, KS, Dr. Shaw worked for the Centers for Disease Control and Prevention (CDC), Children's Mercy Hospital, the University of Missouri at Kansas City School of Medicine, and Smith Kline Laboratories. I've followed his work for many years, use Great Plains Laboratory for biomedical testing every day in my practice, and am exceedingly pleased to share these moments with his profound experience for our CBJ listeners. Recently Dr. Shaw added https://www.greatplainslaboratory.com/gpl-tox/ (GPL-TOX) to measure brain toxins to Great Plains Labs armamentarium of essential mind tools. This CBJ Special 1-hour review will help listeners understand this possible next step for treatment failure globally. Ed Note: See Dr. Shaw's Bonus Notes below ↓ with many brain toxin reference topics for further review on this essential measurement tool. It's important to note that he is the author of two outstanding contributions to the evolution for the treatment of Autism, http://geni.us/shaw (Biological Treatments for Autism and PDD), originally published in 1998, and http://geni.us/shaw2 (Autism: Beyond the Basics), published in 2009. He is also a frequent speaker at conferences worldwide, a global authority with broad experience with the value of laboratory data and molecular insights regarding imbalanced brain functions. On a more personal note, Dr. Shaw is the stepfather of a child with autism and has helped thousands of patients and medical practitioners to successfully improve the lives of people with autism spectrum disorders, ADHD/Executive Function, Alzheimer's disease, arthritis, bipolar disorder, chronic fatigue, depression, fibromyalgia, immune deficiencies, multiple sclerosis, OCD, Parkinson's disease, seizure disorders, tic disorders, Tourette's syndrome, and other serious conditions. In this interview, we discuss useful details regarding the evolution and immediate value of measurements for brain toxins about many of these conditions. Dr. Shaw's Insightful Brain Toxin Details Here - CBJ/125GPL-TOX fulfills my lifetime wish to make toxin testing available for the public [spp-timestamp time="4:49"] 90% of the people don't know specific toxin exposure and could spend $20,000 searching [spp-timestamp time="6:00"] GPL-TOX tests for 172 different chemicals at about $200 [spp-timestamp time="6:42"] What high values on GPL-TOX testing mean medically [spp-timestamp time="7:49"] My first clinical case awareness on the relevance of brain toxins [spp-timestamp time="10:11"] Carbon Monoxide can cause kleptomania and death [spp-timestamp time="12:50"] One of the easiest things to remember about toxins [spp-timestamp time="13:22"] Humans are the most vulnerable to brain toxins and psych problems [spp-timestamp time="14:14"] Most common way they cause brain deterioration is through mitochondria [spp-timestamp time="15:52"] If you're waiting for the government to monitor toxins you might as well wait for the tooth fairy [spp-timestamp time="20:20"] The public must know: toxins cause a wide variety of mind/medical problems [spp-timestamp time="22:01"] Details for treatment and detox [spp-timestamp time="29:58"] Three treatments including sauna notes from 9-11 [spp-timestamp time="33:07"] Clinical observations regarding GPL-TOX for autism [spp-timestamp time="38:40"] Note on my recent article on glyphosate/GMO [see download below↓] [spp-timestamp time="39:40"] Glyphosate, clostridia and HPHPA values on OATS testing-...

Most people believe that yoga, meditation, and prayer have positive effects on the mind, body, and spirit, but what does science say? What sort of research is being done in these fields? Join us with Dr. Amitava Dasgupta as we discuss some of the amazing work being done to further our understanding of how meditation, yoga and prayer can affect us, and what we can learn from these ancient and modern practices. Dr. Amitava Dasgupta was born in Calcutta, India and came to the United States in 1980 and received his Ph.D. in 1986 in Chemistry from Stanford University. He is board certified in both Toxicology and Clinical Chemistry by the American Board of Clinical Chemistry. Currently, he is a tenured Full Professor of Pathology and Laboratory Medicine at the University of Texas Medical School. Dr. Dasgupta has published 214 papers in peer-reviewed journals and is on editorial board of five international journals. Although a toxicologist by profession, Dr. Dasgupta learned yoga and meditation from his teachers in India. His new book The Science of Meditation, Yoga and Prayer is published through Blue River Press and Cardinal Publishers Group, and is available where ever books are sold. Special Guest: Dr. Amitava Dasgupta Email: Amitava.Dasgupta@uth.tmc.edu Host: Ashton Szabo www.anatomyofliving.com Sound Engineer: Zach Cooper Producer: Benn Mendelson www.sivanaspirit.com www.sivanapodcast.com Enter to win our weekly contests at: www.sivanaspirit.com/contest/