Podcasts about mccafferty

Labhraíonn an Dr Máire McCafferty le Seán faoina ról nua mar léachtóir cúnta in Ollscoil Teicneolaíochta an Oirdheiscirt, a cuid taighde, a taithí san Eorap agus an méid atá bainte amach aici.

Country music Singer/Songwriters Nicole McCafferty of Broadtree and Justine Chantale https://linktr.ee/broadtree https://www.justinechantale.com/ This podcast is powered by ZenCast.fm

In 1973 in Sydney, a delusional young criminal and his band of disciples set out to ‘Kill Seven' as a way to resurrect a dead child.For a free trial that will give you access to ad-free, early and bonus episodes:Patreon: patreon.com/forgottenaustraliaApple: apple.co/forgottenaustraliaTo buy They'll Never Hold Me:https://www.booktopia.com.au/they-ll-never-hold-me-michael-adams/book/9781923046474.htmlThe Murder Squad:https://www.booktopia.com.au/the-murder-squad-michael-adams/book/9781923046504.htmlHanging Ned Kelly:https://www.booktopia.com.au/hanging-ned-kelly-michael-adams/book/9781922992185.htmlAustralia's Sweetheart:https://www.booktopia.com.au/australia-s-sweetheart-michael-adams/book/9780733640292.htmlEmail: forgottenaustraliapodcast@gmail.com Hosted on Acast. See acast.com/privacy for more information.

When you join our Lez Hang Out family on Patreon you will gain instant access to 24 and counting full-length bonus episodes, ad-free weekly episodes, mp3 downloads of all our original songs, an invite to our exclusive Discord channel, and more. A Patreon membership also makes for a fun and unique holiday gift for that friend who probably already has enough candles and coffee mugs (although if they don't have enough after all, we have those too!). Welcome back to Lez Hang Out, the podcast that thinks Vanessa Hudgens just may be the best actress of our time.  This week, Leigh (@lshfoster) and Ellie (@elliebrigida) hang out with Catherine McCafferty (@catherine_mccaff), host of the viral Patreon digital series Pretty Gay, to talk about why Netflix's 2019 Christmas romcom The Knight Before Christmas Should've Been Gay.  If you know us, you know how much we unironically love The Princess Switch trilogy. This movie has a similarly unhinged plot and more zany “Christmas magic” shenanigans than you can shake a candy cane at (although sadly, only one Vanessa Hudgens).  What The Knight Before Christmas lacks in Vanessa Hudgens clones it makes up for in the introduction of Sir Cole, a golden retriever girlfriend from the 1300s that Brooke (Vanessa Hudgens) hits with her car and brings home with her. For our gay retelling we can't help but see Sir Cole's quest to become a ‘true knight', something he apparently could not accomplish in his own time period, as a trans allegory.  In addition to the clear trans allegory, the entire story takes place over only 7 days! Within what is essentially one week-long date, Sir Cole has thoroughly convinced Brooke, her hot sister Madison, and the whole town that he is telling the truth with no physical proof. Nothing about the other characters' reactions to Sir Cole makes a lick of sense if this is a straight romcom. What woman is going to give an apparently mentally unstable man she has just met a key to her house? That's not a romcom, that's a horror movie. But when we put on our gay glasses and see Cole as the trans character he was meant to be, the result is a lesbian u-haul tale as old as time. We know one thing for sure, The Knight Before Christmas Should've Been Gay. We are heading to France from March 31st through April 6th for this year's BIG GAY TRIP! Join Ellie and Leigh for a vacay to Bordeaux and Paris where we will tour a winery, explore the catacombs, and dance the night away at the best gay bars. Make a 25% deposit by January 1st in order to secure your spot on the trip. Space is limited, so sign up soon! Give us your own answers to our Q & Gay on Instagram and follow along on Facebook, TikTok, and BlueSky @lezhangoutpod.  You can find your fav tol and smol hosts Ellie & Leigh at @elliebrigida and @lshfoster respectively. Learn more about your ad choices. Visit megaphone.fm/adchoices

Catherine McCafferty is an actor, writer and stand-up. Originally a scrappy Chicagoan where she dabbled in theater, now she splits her time between LA and NYC. See her new digital series Pretty Gay on Patreon.  Recently she's  back from a successful Edinburgh Fringe run of her solo show: (Not) That Bad and wrapping her second feature a queer rom-com, Crush, streaming on Hulu.  Bothered is a web-series she co-created/wrote/starred in with Seth Daniel. Listen in as Anne and Catherine talk rosaries, first Communion, and the cultural vortex that is the Irish Catholic southside of Chicago.CONNECT!Want to watch the full video of this episode? WE HAVE PATREON!  http://www.patreon.com/LapsedPodcast Share your stories, thoughts, and questions with us at lapsedpodcast@gmail.com or at www.lapsedpodcast.com or call us and leave a message at 505-6-LAPSED.Follow us on Twitter (@lapsedpodcast) Instagram (@lapsedpodcast) and Facebook.Subscribe. Rate. Review. Tell your friends!

UPDATE: Please delete, refresh, and redownload if you hear an issue of overlapping audio during the intro. Catherine McCafferty has never seen "Die Hard" but she rewrote it! Enjoy her full take on what she only knew as "a Christmas movie." We kick things off with some talk about laughing at grief after Kyle accidentally texted a friend who's passed away. Kyle and Catherine are joined by Lindsay Adams! Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode Nikkiey Stott sits down with Hatty McCafferty, host of the Real Menopause Talk podcast, for an open and informative conversation on menopause—an often misunderstood and overlooked stage in women's health. Hatty shares her mission to bring real, unfiltered conversations about menopause to the forefront, debunking myths and addressing the physical and emotional shifts women experience. Together, they dive into the importance of awareness, how to prepare for the menopause journey, and ways to support both mental and physical well-being during this pivotal life phase. Whether you're approaching menopause, in the midst of it, or supporting a loved one, this episode is packed with empowering insights and tips.Stay connected with Hatty on Instagram at @realmenopausetalk, via email hatty@realmenopausetalk.com or visit her website https://realmenopausetalk.com/ Click To Watch A Free Macro TrainingClick To Apply For Our ProgramsIf you've got a story about how The Macro Hour Podcast has positively impacted your life, we'd love to hear from you! Fill out this short form for a chance to be featured!Wanna collaborate with WarriorBabe? Click HERE! Follow Nikkiey and WarriorBabe's Socials:WarriorBabe - Instagram | Facebook | YouTube | WebsiteNikkiey - Instagram | Facebook | TikTok Welcome to The Macro Hour Podcast, where we talk about mindset, methodology, and tactics that will help you lose body fat, build muscle, be strong, and feel insanely confident. We've got a no-bullshit, no-nonsense approach with a lot of love and heart to help you reach your goals.

We recently did our second MSC Club visit to New York Red Bulls to interview Academy Director, Sean McCafferty. Our last conversation with Sean was during lockdown in 2020, and we wanted to follow-up and get his insights on the evolution of the Red Bull system and the growth of US professional player development over the last 2-3 years. Sean was extremely generous with both his time and sharing the club methodology as he discussed the playing principles at youth level, coaching and staff profiles, leadership in a forward thinking organization, and the challenges of coaching a true pressing style.

De heilige Carolus Borromeo wordt herinnerd om zijn diepe toewijding aan de sacramenten en de Heilige Eucharistie. De Kerk viert zijn feestdag op 4 november. Hij staat bekend als kerkhervormer en theoloog. Vandaag gaan we samen drie gebeden bidden, toegeschreven aan hem: Gebed tot je beschermengel voor een gelukkige dood Mijn goede engel: Ik weet […]

It's National Coming Out Day, and Lauren is joined by the hilarious and talented Catherine McCafferty, host of the digital series Pretty Gay! Pretty Gay (which is also how Catherine identifies) is an interview series in which Catherine goes on mock dates with queer comedians and creators, and this season even has her bringing on her ex-girlfriend (#brave). Catherine explains how, throughout high school and college, she genuinely never had an inkling that she might be queer, despite once telling a therapist that she was going to marry a man and "watch him die," after which she would get to have a "second life" where she dated women (classic!). Catherine and Lauren commiserate over how difficult breakups are when your entire queer identity feels tied to your first relationship, and bond over having BOTH done shows that required them to go on fake dates (that sometimes felt real...). Plus, Catherine discusses playing the FMK-inspired "finger, U-Haul, ghost" with her very own mother!Season 2 of Pretty Gay is airing right now on Patreon at patreon.com/PrettyGay. Only $5/month to see alllllll the gayness (and there's even a 7-day free trial)! Also check out Pretty Gay's YouTube channel at youtube.com/@PrettyGayShow, and follow Catherine on Instagram and TikTok at @catherine_mccaff. Happy National Coming Out Day, everybody!

Grayson speaks with writer, James T. McCafferty about his new book, Bird Dog Man, The Story of W.W. Titus, Father of the National Bird Championshipo Field Trials Learn more about your ad choices. Visit megaphone.fm/adchoices

Was the real Edinburgh Fringe Festival the friends we made along the way? This week, Mo's unwinding with Catherine McCafferty and Demi Adejuyigbe before they all head back to LA. They talk about balancing their personal lives with their art, finding authentic relationships, and how far they'd commit to a bit for love. And hey, guess what, it's all about process. The Edinburgh Fringe Festival may be a wrap, but we're still at it! Stay tuned for more episodes of Worse Than You, featuring Fringe headliners... and beyond. Catherine McCafferty is an actor and stand-up who just wrapped her Edinburgh Fringe Festival run of her solo show (Not) That Bad. You can check out her digital series Pretty Gay on Patreon, and see her in projects like Crush on Hulu. Demi Adejuyigbe is a writer, comedian, filmmaker, and musician. He just wrapped his Fringe show Demi Adejuyigbe Is Going To Do One (1) Backflip, for which he was nominated for The 2024 DLT Entertainment Best Newcomer Award. Check out Demi's first chat with Mo here. Worse Than You with Mo Fry Pasic is hosted by Mo Fry Pasic. Our executive producers are Lauren Mandel and Erica Getto. Our associate producer is Carmen Carigan. Charlotte Harrison designed our show art, and Brandon Young photographed Mo for our show art. Special thanks to Myrriah Gossett for setting up our Edinburgh tech kit. We're on Instagram @worsethanyoushow. You can learn more about the stage show Worse Than You here. Worse Than You with Mo Fry Pasic is co-produced by Disco Nap and Kinehora Productions. Learn more about your ad choices. Visit megaphone.fm/adchoices

In this conversation fine art landscape photographer, Michael McCafferty discusses his passion for landscape photography, detailing how he began taking simple family photos and evolved into a more dedicated hobbyist capturing the stunning scenery of Ireland.  He highlights the emotional and mental health benefits he derives from his craft, shares his experiences with photography clubs and mentorship, and talks about the balance between his job as a computer programmer and his love for photography.  Michael also outlines his creative process, touching upon both in-field shooting and post-processing techniques, his experiences in photography competitions, and the supportive nature of the photography community.  I hope you enjoy the show!   You can find Michael's work  here: Linktree: https://linktr.ee/michaelmccaffertyphotography Twitter: https://x.com/MickMcC_Photos Instagram: https://www.instagram.com/michaelmccaffertyphotography/     Listen to this and other episodes wherever you find your podcasts or on https://grantswinbournephotography.com/lpw-podcast   Or subscribe to my YouTube channel https://youtube.com/@grantswinbournephotography Theme music: Liturgy Of The Street by Shane Ivers - https://www.silvermansound.com   #podcast #landscapephotography

Peter McCafferty works on Zero Waste Scotland's Circular Economy Business Support Service (CEBS). These services were launched back in 2017, and since then, Peter has worked with over 200 SMEs and large organisations, so he's got a wealth of experience and insights to share with us, especially on the fuel and friction around the circular economy. Zero Waste Scotland is a not-for-profit environmental organisation funded by the Scottish Government and the European Regional Development Fund. Its purpose is to lead Scotland to use products and resources responsibly, focusing on where it can have the greatest impact on climate change. It aims to both inform government policy, and to motivate individuals and businesses to embrace the environmental, economic, and social benefits of a circular economy. Peter has over 13 years of experience of working in sustainability and resource management, and his role involves working with individual businesses to identify, shape and develop circular and sustainable business ideas through a mix of 1-1 coaching and engagement, as well as facilitating bespoke support via Zero Waste Scotland's dedicated CE Framework. Our discussion includes: What's the big ‘why' behind ZWS, and in a practical sense, how does it provide support for businesses in Scotland that want to adopt circular solutions? What kind of things are providing the ‘fuel' for the circular economy, and why digital solutions are coming to the fore as key enablers of circularity. We discuss some of the barriers to circular approaches, including regulatory challenges, scaling issues, and underestimated waste reduction potential. These days, we're all living in a VUCA world – volatile, uncertain, complex and ambiguous - and we discuss the importance of systems thinking, especially in getting to grips with the challenges of implementation and addressing complex global issues. We share our thoughts on the ongoing struggle with language and interpretation of circular economy, and Peter talks about the increasing focus on carbon footprinting and net zero policies, and how seems to be getting in the way of conversations for circularity.

Our reporter Aine Ni Gallachoir was in McCafferty's home city of Derry for the funeral

Journalist, author and activist Nell McCafferty has died aged 80, her family has announced.Born in Derry in 1944, McCafferty was a founding member of the Irish Women's Liberation Movement and spent her life campaigning for women's rights and against social injustices.She spoke to Matt in 2018 about why she was voting ‘Yes' in the abortion referendum.Revisit the interview here by hitting the ‘Play' button on this page.

Bill discussed his experiences and strategies in the buying and selling notes, with a focus on residential seconds and the considerations involved in foreclosure sales. He also explored the complexities of managing different levels of client portfolios, the risks and strategies of second mortgage lending, and the importance of due diligence, education, and communication in the note investing business. Lastly, he shared their concerns about the industry, Bill's recent return to podcasting, and the need for integrity and communication in the business. Are you Ready to work with Dan to accelerate your note-investing journey? SMALL GROUP LIVE COACHING: https://www.fusionnotes.com/livetraining PREMIUM CONTENT: Get a roadmap that shows you a step-by-step path for being a note investor, https://fusionnotes.ac-page.com/gameplan NOTE INVESTING ONLINE COURSES: https://www.fusionnotes.com/courses/ DAN'S LINKS FOR PODCAST LISTENERS: https:www.fusionnotes.com/listeners Get the FREE EBOOK on How to Make Outsized Profits in Notes in 2024: https://fusionnotes.ac-page.com/newsletter-signup-page-podcast WEBSITE: https://fusionnotes.com  

Catherine McCafferty is an actor and stand-up who splits her time between LA and NYC. This summer (2024) Catherine will be taking her solo show: (Not) That Bad, to the Edinburgh Fringe Festival. Recently Catherine wrapped her second feature a queer rom-com: Crush streaming now on Hulu. She had the pleasure of attending the Austin Film Festival with an original script she wrote, and has performed at the Edinburgh Fringe, Dallas Comedy Fest, Portland Comedy fest and the Vail Comedy Fest. Bothered, is a web-series she co-created/wrote/starred in with Seth Daniel and was accepted into the New York City TV Fest 2018. Her new digital series Pretty Gay is on Patreon. She also stared in the film American Carnage with Jenna Ortega .Catherine McCafferty is guest number 398 on My Time Capsule and chats to Michael Fenton Stevens about the five things she'd like to put in a time capsule; four she'd like to preserve and one she'd like to bury and never have to think about again .Tickets for Catherine's Edinburgh show are available here: https://tickets.edfringe.com/whats-on/catherine-mccafferty-not-that-bad ,Follow Catherine McCafferty on Instagram: @catherine_mccaff .Follow My Time Capsule on Twitter, Instagram & Facebook: @MyTCpod .Follow Michael Fenton Stevens on Twitter: @fentonstevens & Instagram @mikefentonstevens .Produced and edited by John Fenton-Stevens for Cast Off Productions .Music by Pass The Peas Music .Artwork by matthewboxall.com .This podcast is proud to be associated with the charity Viva! Providing theatrical opportunities for hundreds of young people. Get bonus episodes and ad-free listening by becoming a team member with Acast+! Your support will help us to keep making My Time Capsule. Join our team now! https://plus.acast.com/s/mytimecapsule. Hosted on Acast. See acast.com/privacy for more information.

Catherine McCafferty is an actor and stand-up who splits her time between LA and NYC. This summer (2024) Catherine will be taking her solo show: (Not) That Bad, to the Edinburgh Fringe Festival. Recently Catherine wrapped her second feature a queer rom-com: Crush streaming now on Hulu. She had the pleasure of attending the Austin Film Festival with an original script she wrote, and has performed at the Edinburgh Fringe, Dallas Comedy Fest, Portland Comedy fest and the Vail Comedy Fest. Bothered, is a web-series she co-created/wrote/starred in with Seth Daniel and was accepted into the New York City TV Fest 2018. Her new digital series Pretty Gay is on Patreon. She also stared in the film American Carnage with Jenna Ortega .Catherine McCafferty is guest number 398 on My Time Capsule and chats to Michael Fenton Stevens about the five things she'd like to put in a time capsule; four she'd like to preserve and one she'd like to bury and never have to think about again .Tickets for Catherine's Edinburgh show are available here: https://tickets.edfringe.com/whats-on/catherine-mccafferty-not-that-bad ,Follow Catherine McCafferty on Instagram: @catherine_mccaff .Follow My Time Capsule on Twitter, Instagram & Facebook: @MyTCpod .Follow Michael Fenton Stevens on Twitter: @fentonstevens & Instagram @mikefentonstevens .Produced and edited by John Fenton-Stevens for Cast Off Productions .Music by Pass The Peas Music .Artwork by matthewboxall.com .This podcast is proud to be associated with the charity Viva! Providing theatrical opportunities for hundreds of young people. Get bonus episodes and ad-free listening by becoming a team member with Acast+! Your support will help us to keep making My Time Capsule. Join our team now! https://plus.acast.com/s/mytimecapsule. Hosted on Acast. See acast.com/privacy for more information.

Tá na coláistí samhraidh mar chuid lárnach d'fhorbairt shóisialta déagóirí na tíre, ach ní mar sin a bhí sé i gcónaí. Labhraíonn muid le Máire McCafferty faoi conas mar a thosaigh siad amach.

(Chris Mueller and Joe Starkey) -QUIZ SHOW!!!! IT'S INCRINCULENT!!!! -Bob McCafferty of North Country Brewing joins! Chris and Joe then share some of the first legal drinks they had back in the day. Also, what might the nickname for the new Utah NHL team be? -Chris, Joe, and Kraig reminisce about all of their favorite memories from doing shows together!

Catherine has performed stand up comedy for 8 years. Originally from Chicago, USA, she moved to LA via New York City. This is her origin story. She also talks about her 2024 Edinburgh Fringe show, 'Catherine McCafferty: (Not) That Bad'. Image by Lee Jameson. Presented by Martin Walker. Catherine's Profile and Social Media HERE  

Shaun McCafferty has a brilliant new live album that will be going out on all the streaming platforms tomorrow. Here's a sneak peek of one of the tracks -- a wonderful rendition of "St. Patrick Battalion."

It's YOUR time to #EdUp In this very special episode, recorded LIVE onstage & in person from the InsightsEDU 2024 conference in Phoenix, AZ YOUR guests are Sarah Russell, VP, Marketing, Chris Gilmore, VP, Enrollment Management, & Becky McCafferty, VP, Account Management, EducationDynamics YOUR hosts are Dr. Joe Sallustio & Tracy Kreikemeier, Chief Relationship Officer, EducationDynamics Listen in to #EdUp! Thank YOU so much for tuning in. Join us on the next episode for YOUR time to EdUp! Connect with YOUR EdUp Team - Elvin Freytes & Dr. Joe Sallustio ● Join YOUR EdUp community at The EdUp Experience! We make education YOUR business! --- Send in a voice message: https://podcasters.spotify.com/pod/show/edup/message

ag comhrá faoi chomhdháil ar na coláistí Gaeilge a bhéas i UCD i mí Iúil.

Good morning Boca del Mar! This week we hear from junior Aiden Kudley about his hallway shortcuts; Mr. James Patterson (no relation) about his historical theories; and Fire Boy about his fires. Thanks to special guest Connor McCafferty for joining us this week!

Guest post by Jamie Elkaleh is an experienced public speaker, dedicated crypto enthusiast and educator, and Bitget's Country Manager. Bitget Empowers Blockchain Dialogue at the Heart of Dubai with Sponsorship of Blockchain Ireland Meetup Bitget, a leading platform in the cryptocurrency and blockchain space, proudly sponsored the latest Blockchain Ireland meetup event in Dubai, held at McCafferty's in JVC. The event, which took place on February 23, 2024, attracted over 30 professionals from diverse companies and backgrounds, fostering a rich environment for networking and knowledge exchange. Blockchain Ireland Meet Up in Dubai Lory Kehoe, the esteemed founder and Chair of Blockchain Ireland and MSX Head of Stablecoin, was in attendance, adding significant value to the discussions. "Blockchain Ireland was delighted to host our first (but not last) UAE meet-up with Bitget. 50 people from around the world (not just Ireland) came together to discuss the latest developments with L2s, the future of NFTs and tokenization. Looking forward to the next one",- said Lory. The event marked a pivotal moment for the blockchain community in Dubai, creating a platform for collaborative conversations and partnerships. Bitget Country Manager, Jamie Elkaleh commented, "Sponsorship of this event highlights our commitment to providing networking and educational opportunities to the Irish Crypto community." Elkaleh's statement reflects Bitget's dedication to supporting and nurturing the growth of the blockchain community, not only in Dubai but globally. Opportunities arising from the event were plentiful, with participants delving into discussions about recruiting talents, hosting more web3 focused events, expanding networking circles, and connecting with venture capitalists and other investors in the blockchain space. Key topics of conversation ignited passionate discussions, covering the latest trends and developments in the industry. Conversations ranged from the prospects of a Bitcoin ETF, the burgeoning Defi Summer, the impact of Layer 2 solutions, the diverse world of Altcoins, to the stability of Stablecoins. Industry challenges were not overlooked, as participants delved into barriers to entry and contemplated the implications of the Bitcoin halving and ETF on the broader market. Bitget's sponsorship of the Blockchain Ireland meetup underscores its commitment to fostering an inclusive and collaborative blockchain ecosystem in Dubai. The company believes in the power of such events to drive innovation, collaboration, and growth within the industry. As the blockchain community eagerly anticipates the next gathering in conjunction with Blockchain Ireland, Bitget remains dedicated to supporting initiatives that propel the industry forward, fostering a dynamic and thriving blockchain landscape. Written by Jamie Elkaleh is an experienced public speaker, dedicated crypto enthusiast and educator, and Bitget's Country Manager. He focuses on breaking the barrier of entry for crypto users through free education content and established brands. Before diving into the crypto world, Jamie Elkaleh was a professional rugby coach who worked with England's National Rugby Team. His professional experience working with young people started with his foundational degree in youth work at Liverpool John Moores University. Jamie has been building the platforms needed to educate and onboard young people to the crypto space ever since. His two educational platforms, CryptoJamie and CryptoBrosUK, have been the foundation of his brand, leading to his partnership with Binance as a crypto content creator. Through that partnership, he was able to reach more than 500k viewers each week, educating and encouraging the future and current leaders of the crypto space. With his current role as Bitget's Relationship Manager, Jamie works to build relationships and broaden the horizon of the platform while onboarding a wide range of users, influencers, and start-ups. Career Since ...

Catherine McCafferty joins Kurt and Scotty to talk about a falcon sex hat, a baby found alive in a tree after being sucked up by a tornado, ChatGPT candy hearts and a frugal man who left his town millions of dollars they didn't know he had! Learn more about your ad choices. Visit megaphone.fm/adchoices

Jim Collins is one of the leading biomedical engineers in the world. He's been elected to all 3 National Academies (Engineering, Science, and Medicine) and is one of the founders of the field of synthetic biology. In this conversation, we reviewed the seminal discoveries that he and his colleagues are making at the Antibiotics-AI Project at MIT.Recorded 5 February 2024, transcript below with audio links and external links to recent publicationsEric Topol (00:05):Hello, it's Eric Topol with Ground Truths, and I have got an extraordinary guest with me today, Jim Collins, who's the Termeer Professor of Medical Engineering at MIT. He also holds appointments at the Wyss Institute and the Broad Institute. He is a biomedical engineer who's been making exceptional contributions and has been on a tear lately, especially in the work of discovery of very promising, exciting developments in antibiotics. So welcome, Jim.Jim Collins (00:42):Eric, thanks for having me on the podcast.Eric Topol (00:44):Well, this was a shock when I saw your paper in Nature in December about a new structure class of antibiotics, the one from 1962 to 2000. It took 38 years, and then there was another one that took 24 years yours, the structural antibiotics. Before I get to that though, I want to go back just a few years to the work you did published in Cell with halicin, and can you tell us about this? Because when I started to realize what you've been doing, what you've been chipping away here, this was a drug you found, halicin, as I can try to understand, it works against tuberculosis, c. difficile, enterobacter that are resistant, acinetobacter that are resistant. I mean, this is, and this is of course in mice models. Can you tell us how did you make that discovery before we get into I guess what's called the Audacious Project?Jim Collins (01:48):Yeah, sure. It's actually a fun story, so it is origins go broadly to institute wide event at MIT, so MIT in 2018 launched a major campus-wide effort focused on artificial intelligence. The institute, which had played a major role in the first wave of AI in the 1950s, 1960s, and a major wave in the second wave in the 1980s found itself kind of at the wheel in this third wave involving big data and deep learning and looked to correct that and to correct it the institute had a symposium and I had the opportunity to sit next to Regina Barzilay, one of our faculty here at MIT who specializes in AI and particularly AI applied to biomedicine and we really hit it off and realized we had interest in applying AI to drug discovery. My lab had focused on antibiotics to then close to 15 years, but primarily we're using machine learning and network biology to understand the mechanism of action of antibiotics and how resistance arise with the goal of boosting what we already had, with Regina we saw there was an opportunity to see if we could use deep learning to get after discovery.(02:55):And notably, as you kind of alluded in your introduction, there's really been a discovery void and the golden age of discovery antibiotics was in the forties, fifties and sixties before I was born and before you had the genomic revolution, the biotech revolution, AI revolution. Anyways, we got together with our two groups, and it was an unfunded project and we kind of cobbled together very small training set of 2,500 compounds that included 1,700 FDA approved drugs and 800 natural compounds. In 2018, 2019, when you started this, if you asked any AI expert should you initiate that study, they would say absolutely not, there's going to be two big data. The idea of these models are very data hungry. You need a million pictures of a dog, a million pictures of a cat to train a model to differentiate between the cat and the dog, but we ignored the naysayers and said, okay, let's see what we can do.(03:41):And we apply these to E. coli, so a model pathogen that's used in labs but is also underlies urinary tract infections. So it's a look to see which of the molecules inhibited growth of the bacteria as evidence for antibacterial activity and we could have measured and we quantified each of their effects, but because we had so few compounds, we just discretized instead, if you inhibited at least 80% of the growth you were antibacterial, and if you didn't achieve that, you weren't antibacterial zero in ones. We then took the structure of each molecule and trained a deep learning model, specifically a graphical neural net that could look at those structures, bond by bond, substructure by substructure associated with whatever features you look to train with. In our case, making for good antibiotic, not for good antibiotic. We then took the train model and applied it to a drug repurposing hub as part of the Broad Institute that consists of 6,100 molecules in various stages of development as a new drug.(04:40):And we asked the model to identify molecules that can make for a good antibiotic but didn't look like existing antibiotics. So part of the discovery void has been linked to this rediscovery issue we have where we just keep discovering quinolones like Cipro or beta-lactams like penicillin. Well, anyways, from those criteria as well as a small tox model, only one molecule came out of that, and that was this molecule we called halicin, which was named after HAL, the killing AI computer system from 2001 Space Odyssey. In this case, we don't want it to kill humans, we want it to kill bacteria and as you alluded, it turned out to be a remarkably potent novel antibiotic that killed off multi-drug resistant extensively drugs, a pan-resistant bacteria went after to infections. It was affected against TB, it was affected against C. diff and acinetobacter baumannii and acted to a completely new mechanism of action.(05:33):And so we were very excited to see how AI could open up possibilities and enable one to explore chemical spaces in new and different ways. We took them model, then applied it to a very large chemical library of 1.5 billion molecules, looked at a subset of about 110 million that would be impossible for any grad student, any lab really to look at that experimentally but we looked at it in a model computer system and in three days could screen those 110 million molecules and identified several new additional candidates, one which we call salicin, which is the cousin of halicin that similes broad spectrum and acts to a novel mechanism of action.Eric Topol (06:07):So before we go further with this initial burst of discovery, for those who are not used to deep neural networks, I think most now are used to the convolutional neural network for images, but what you use specifically here as you alluded to, were graph neural networks that you could actually study the binding properties. Can you just elaborate a little bit more about these GNN so that people know this is one of the tools that you used?Jim Collins (06:40):Yeah, so in this case, the underlying structure of the model can actually represent and capture a graphical structure of a molecule or it might be of a network so that the underlying structure itself of the model will also look at things like a carbon atom connects to an oxygen atom. The oxygen atom connects to a nitrogen atom and so when you think back to the chemical structures we learned in high school, maybe we learned in college, if we took chemistry class in college, it was actually a model that can capture the chemical structure representation and begin to look at sub aspects of it, associating different properties of it. In this case, again, ours was antibacterial, but it could be toxic, whether it's toxic against a human cell and the model, the train model, the graph neural model can now look at new structures that you input them and then make calculations on those bonds so a bond would be a connection between two atoms or substructures, be multiple bonds, interconnecting multiple atoms and assign it a score. Does it make, for example, in our case, for a good antibiotic.Eric Topol (07:48):Right. Now, what's also striking as you set up this collaboration that's interdisciplinary with Regina, who I know of her work through breast cancer AI and not through drug discovery and so this was, I think that new effort and this discovery led to this, I love the name of it, Audacious Project, right?Jim Collins (08:13):Right. Yeah, so a few points on the collaboration then I'll speak to Audacious Project. In addition to Regina, we also brought in Tommi Jaakkola, another AI faculty member and marvelous colleague here at MIT and really we've benefited from having outstanding young folks who were multilingual. We had very rich, deep trained grad students from ML on Regina and Tommi's side who appreciated the biology and we had very richly, deeply trained postdocs, Jon Stokes in particular from the microbiology side on my side, who could appreciate the machine learning and so they could speak across the divide. And so, as I look out in the next few decades in this exciting time of AI coming into biomedicine, I think the groups will make a difference of those that have these multilingual young trainees and two who are well set up to also inject human intelligence with machine intelligence.(09:04):Brings the Audacious Project. Now, prior to our publication of halicin, I was invited by the Audacious Project to submit a proposal, the Audacious Project is a new philanthropic effort run by TED, so the group that does the TED Talks that's run by Chris Anderson, so Chris had the idea that there was a need to bring together philanthropists around the world to go for a larger scale in a collective manner toward audacious projects. I pitched them on the idea that we could use AI to address the antibiotic resistance crisis. As you can appreciate, and many of your listeners can appreciate that we're doomed if we don't actually address this soon, in that the number of resistance strains that are in our communities, in our hospitals has been growing decade upon decade, and yet the number of new antibiotics being developed and approved has been dropping decade upon decade largely because the antibiotic market is broken, it costs just as much to develop an antibiotic as it does a cancer drug or a blood pressure drug.(09:58):But antibiotic you take once or maybe over the course of three to five days, blood pressure, drug cancer drug you might take for months if not for the rest of your life. Pricing points for antibiotics are small dollars, cancer drugs, blood pressure drugs, thousands if not hundreds of thousands. We pitched this idea that we can maybe turn to AI and use the power of AI to address this crisis and see if we could use our wits to outcompete the genes of superbugs and Chris and his team really were taken with this, and we worked with them over the course of nine months and learned how to make the presentations and pulled this together. Chris took our pitches to a number of really active and fantastic philanthropists, and they got behind us and gave us a good amount of money to launch what we have now called the Antibiotics-AI Project at MIT and in conjunction with it and also using funding from the Audacious Project, we've launched a nonprofit called Phare Bio which is French for lighthouse, so our notion is that antibiotics are public good that we need to get behind his community and Phare Bio, which is run by Akhila Kosaraju, she's the CEO and President, is the mission of which is to take the most promising molecules out of the antibiotics AI project and advance them towards the clinic through partnerships with biotech, with pharma, with other nonprofits, with nation states as needed.Eric Topol (11:18):Well, before I get to the next chain of discovery and as explain ability features, which we all like to see when you can explain stuff with AI, did halicin because of this remarkable finding, did it get into clinical trials yet?Jim Collins (11:36):It's being advanced quite nicely and aggressively by Phare Bio. So Phare Bio is in discussions with the Department of Defense and BARDA, and actually on an interesting feature of halicin is that it acts like a flash bomb in the gut, meaning that when delivered orally to the gut, it only acts briefly and very quickly in a fairly narrow spectrum manner as well, so that it can go after pathogens sparing the commensals. One of the challenges our US military face is one of the challenges many militaries face are gut issues when soldiers are first deployed to a new location, and it can disable the soldiers for three to four weeks. And so, there's a lot of excitement that halicin might be effective as a treatment to help prevent gut dysbiosis resulting from new deployments.Eric Topol (12:27):Oh wow. That's another application that I would never have thought of. Interesting, so you then moved on to this really big report in Nature, which I think this is now involving a transformer model as I recall. So you can explain the difference and you made a discovery from a massive, again, number of potential compounds to staph aureus resistant methicillin resistant agents that were very potent in vivo. So how did you make this big jump? This is a whole new structural class of antibiotics.Jim Collins (13:11):Yeah, so we made this jump, this was an effort led by Felix Wong, who's a really talented postdoc in my lab, and we got intrigued of to what extent could we expand the utility of AI and biology of medicine. As you can appreciate that, that many of our colleagues are underwhelmed by the black box nature of many AI models and by black box I mean that when you train your model, you then largely use it as a filter where you'll provide the model with some input. You look at the output and the outputs, what's of interest to you, but you don't really understand in most cases, what guided the model to make the prediction of the output that you look at and that can be very unsatisfactory for biology, interested in mechanism. It can be very unsatisfactory for physicians interested in understanding the underlying disease mechanism.(13:57):It can be unsatisfactory for biotech and drug discoveries that want to understand how drugs act and what maybe underlies meaningful structural features. So with Felix, we decided it'd be interesting if you could open up the box. So could you look inside the model to see what was being learned? We are able to open up, in this case actually, we primarily focused on graph neural nets. We now have a new piece we're just about to submit on transformers, but in this case, we could open up and look to see what were the rationales, what were the chemical substructures that the model was pointing to in each compound that was leading to the high prediction that it could make for a good antibiotic and these rationales we then used as hooks, I should notably say, that we were able to identify the rationales from these large collections using algorithms that would develop by DeepMind as part of their AlphaGo program.(14:51):So AlphaGo was developed by DeepMind as a deep learning platform to play and win go the ancient Asian board game and we used similar approaches called Monte Carlo Tree Search that allowed us to identify these rationales that we effectively then used as hooks and kind of organizing hooks on screens where you can envision or appreciate that most exposed screens give you one-offs. This molecule does what you want and silico screens are similarly designed with these rationales. We could use them as organizing hooks to say, ah, these compounds that are identified as making for very good antibiotics all have the same substructure and thus they likely in the same class and act in similar mechanism and this led us to identify five novel classes, one of which we highlighted in this piece that acts very effectively against MRSA, so methicillin-resistant staph aureus you alluded, which is probably the most famous of the antibiotic resistant pathogens that we even outside infectious are quite familiar with. It be devil's athletes, so NFL players are often hit with MRSA, whether from scraping their limbs on AstroTurf or from actually surgeries to say, for example, correct something at their knee. This new class had great efficacy in animal models, again, acting through a new mechanism.Eric Topol (16:12):Will you bring that forward like halicin through this same entity?Jim Collins (16:17):Yes. We've now provided the molecules to Phare Bio and they're digging in to see which of these might be the most exciting and interesting to advance clinically.Eric Topol (16:26):I mean, it's amazing because this area is so neglected. Maybe you can help explain, since we're talking about existential threats as we get more and more resistant antibiotics and the biopharma industry is basically not into this and it relies on the work that you've been doing perhaps or other groups, I don't know of any that are doing more than you. I mean, it's incredible to me. Is it just because of the financial aspects that there's no business in the life science industry?Jim Collins (17:03):It's an interesting challenge. So I've thought about it. I really haven't come up with a great solution yet, but I think you've got multiple factors at play. One is that I think all of us, every one of your listeners has lost someone to a bacterial infection, but in most cases you don't realize you lost them to a bacterial infection. It might be that your elderly relative went into the hospital with a condition but acquired hospital-based infection and died subsequently from that and happened quite quickly. Another cases, again, it's secondary. Notably, during the pandemic, one out of seven individuals hospitalized for Covid had a bacterial infection and 50% of those who died had a bacterial co-infection. And noted by going back to the Spanish flu of over a hundred years ago. It was as deadly as it was because we didn't have antibiotics and most of the folks that died had a bacterial co-infection.(17:56):So you have this in the backdrop, you then have that, nobody's kind of gotten behind it, so we don't have any major foundation addressing antibiotic resistance. There are no charity walks, there are no charity runs, there is no month, there is no color, there are no ribbons, there are no celebrity behind it, there's just not known so it hasn't captured the public's imagination. AThen you come with that, this backdrop of the broken market where I said shared, it's really expensive to develop a new antibiotic, but if you develop a new antibiotic, the tendency now will be to shelve it until it's desperate so now even the young companies that had developed and gotten an antibiotic through to approval often went bankrupt because the model, the market couldn't provide them with revenue to go after the next one or sustain their efforts. And so you have pharma biotech jumping out. I think we need two-pronged effort going forward. I do think we need nation states to come forward and get behind this, and I think we increasingly need philanthropists to come forward and go after it. As I share your term of existential threat, I think if you speak with most educated individuals, antibiotic resistance broadly, antimicrobial resistance will be on everyone's existential threat list but notably of that list, it's the cheapest one that can be solved.Eric Topol (19:09):Well, you're showing that you've got the most extraordinary candidates that have been found in decades. So that says a lot right there.Jim Collins (19:18):Important step, yeah. So I think we've got additional innovation needed in the models to address this, and until we have that address, then this interesting discoveries we and others are making will not get to patients. So we need to have that additional next step to close this gap.Eric Topol (19:32):Now, obviously this has relied on AI and the progress that's occurring in AI to enable some of your work. I am fascinated by the use of AlphaGo. Most times we hear about using AlphaFold2, but you actually use AlphaGo the original game DeepMind work but there also was the progress of from deep neural networks to transformer models and your ability now to basically exemplify what can be achieved in drug discovery using the progress in multimodal AI. Is this something that is making a difference for you and your group?Jim Collins (20:13):It is, it's huge. I think it's very early in terms of the introduction to these new tools extensively within drug discovery. Machine learning has been used for over two decades, both supervised learning and unsupervised learning. Now we're seeing groups coming in for the deep learning efforts. It's largely data-driven so in fact, with the exception of sequences, most of drug discoveries not yet big data in the big data phase, but it's beginning to change. It's truly been transformative for us, so we've used graph neural nets primarily for our discovery efforts. We're now beginning to incorporate language models as multimodal models along with the graph neural nets as well as to see to what extent pre-trained language models. For example, mobile form from IBM, which was trained on PubChem and the ZINC database could be fine-tuned with small amounts of training data, screening data from a resistant organism.(21:06):Third, and I made an indirect allusion already, we've been looking at using transformers and genetic algorithms in older form of AI tech for design of novel antibiotics so we've been now looking to see using fragments as a starting base, using trained models to build out novel antibiotics that can then be de novo designed. One of the big challenges in that space is how do you synthesize these molecules? So you have both the challenge of can you come up with a small number of steps that enable you to synthesize? And second is could you find somebody to synthesize them? And each of those remains very big challenges. My faculty colleague here at MIT, Connor Coley's probably one of the world leaders, easily, he's in using AI to calculate the synthesized ability of a molecule, but we still have gaps in that we don't have the community resources to make most of what we come up with.Eric Topol (21:58):Well, one of the features of large language models that David Baker at the Protein Design Institute exploited is its ability to hallucinate and come up with proteins that don't exist. Can you do the same thing in your design of antibiotic candidate molecules in a way that is not worrying about the synthesis, but just basically the hallucinatory behavior of large language models?Jim Collins (22:28):It's interesting, so yes and so David's work is marvelous and we're big fans and longtime friends of his work. Yes, so we've been driving these models truly to do de novo synthesis. So based on what has been learned, can you put together molecules that one's never seen before? We're doing it quite successfully. It becomes interesting from the hallucination in that it comes out really more of these models making stuff up and ours it's really more directing the hallucinations, right? Really looking to see can we harness the imagination of the models in order to move them forward in very creative design manners.Eric Topol (23:08):Yeah, I mean, I think most people have a negative connotation of hallucinations, but these are the smart variety potentially. This in many ways you could say there's so much crowded interest in the drug discovery AI world, but what you're doing now seems to be setting the pace in many respects for others to follow such remarkable advances in a short time. By the way, we'll link to that TED talk you gave in April 2020, where in seven minutes you went over what you're doing of course and who would've, and that was in 2020 that where you'd be three or four years later, and that was what you're going to do over the next seven years with seven new classes of new antibiotics. Now, before we wrap up, it isn't just that you're an AI antibiotic, you and your team antibiotic discover and doing compressing in time, what has taken decades that you're doing in months, but also you are a father of figure in the field of synthetic biology and I wonder if you, before we wrap up, can explain not only what synthetic biology is since a lot of people don't really know what that means, but how does that dovetail with your efforts in what we've been discussing?Jim Collins (24:33):Yeah, thanks. So synthetic biology is a relatively new field that's bringing together engineers with biologists to use engineering principles to model design and build synthetic gene networks and other molecular components that can be used to rewire and reprogram living cells and cell-free systems, endowing them with novel functions of a variety of applications. So the circuits, these programmable cells are impacting broad swats of the economy from food and water to health and sustainability of bioenergy to human health. Our focus is primarily human health and we've been advancing the idea that you can reprogram bacteria to detect and treat bacterial infections. So we've shown you can use this to go after cholera, we've shown you can use is to prevent antibiotic induced gut dysbiosis. We've also used synthetic biology to create whole new classes of diagnostics. For example, paper-based ones using RNA sensors for Ebola, for Zika and for Covid.(25:33):How it dovetails with what we talked about is that I think there's a great opportunity now to turn to AI to expand synthetic biology, both expanding the number of parts we have to re-engineer living systems as well as to better infer design principles that can be used to reprogram rewire living systems. We're beginning to advance, we're not yet at the SynBio AI project phase, but very early efforts and David's dominating the protein space and we and others are beginning to now movement to the RNA space. So to what extent can we create large libraries of RNA components, train language-based models, structure-based models that can both predict RNA structure more critically predict RNA function and as you know from your marvelous work and what's happening is that it's the exciting age of RNA of getting after RNA therapeutics, be it mRNA or CRISPR related and we still need to get better at our ability to design those therapeutics with certain functions in mind, and we think AI is going to help get us there faster.Eric Topol (26:34):Well, speaking of that, there was a paper this week in Cell by McCafferty and colleagues, and one of the sentences that struck me, we are standing on the cusp of a new era of biology, where the integration of multimodal structural datasets with multiscale physics-based simulation will enable the development of visible, virtual cells. This is yet another lineage or direction of where we're headed with AI, but this fusion of the advances that are occurring right now in biology with AI that extend in many different directions, it's so exciting and you are basically nailing it. I mean, you're putting points on the board, Jim, and I just have to say, I'm blown away by what you've been accomplishing in a time space that's so incredibly compressed.Jim Collins (27:40):Oh, well thanks. Well, you think back to the early days of molecular biology and physicists like Francis Crick and Max Delbrück played huge pioneering roles and then in the second wave in the eighties or so, you had other physicists like Walter Gilbert playing big roles. I do think physicists computer scientists are starting now to play big roles in this next phase where we need tools like AI in order to really grapple with and harness the complexity, both the biology and the chemistry that underlies living cells. They can kind of expand our intuitions both to understand and to really control these systems for good going forward.Eric Topol (28:15):Well, you're doing it and we're be cheering for the success of these drugs that you've come up with in the clinical trials as they go forward because they look so remarkably promising. You even highlighted ways that I wouldn't have envisioned where they could make a difference, so we'll follow your work, you and your colleagues with great interest. Thanks so much for joining,Jim Collins (28:37):Eric, thanks for having me. Enjoyed our conversation.******************************************************************************Thanks for listening to Ground Truths. Please share if you found this podcast informative.Full video interview will post here Get full access to Ground Truths at erictopol.substack.com/subscribe

Intro song: Token Back to Brooklyn (1996)55. Bastard Wants to Hit Me (2004)54. Dead (1990)53. Subliminal (1994)52. Out of Jail (1994)51. McCafferty's Bib (2018)Album art discussion

Report after report has shown that sexual harassment and assault are pervasive throughout the U.S. armed forces: at least 15.7 percent of military personnel and veterans reported military sexual trauma, a number that is likely smaller than the actual total due to shame and fear around reporting. What's more, perpetrators are rarely if ever held accountable: according to a recent ProPublica investigation, more than half of the 900 soldiers who were allowed to leave the Army in the past decade rather than go to trial were accused of violent crimes.But in the face of a culture that silences and disenfranchises women and survivors, some women are speaking out—and demanding change. One of them is our very special guest, Melissa McCafferty: Melissa McCafferty is a former Lieutenant with the United States Coast Guard, where she served for 12 years. After being sexually assaulted while in the Coast Guard Academy, she has since become an advocate for military sexual assault victims, including testifying in front of Congress earlier this year. She recently received her JD from Georgetown University Law Center, and serves as a Young Lawyer Representative at the American Bar Association Section of Antitrust Law. Check out this episode's landing page at MsMagazine.com for a full transcript, links to articles referenced in this episode, further reading and ways to take action.Tips, suggestions, pitches? Get in touch with us at ontheissues@msmagazine.com. Support the show

Join me on this weeks show for a chat with singer/co-writer of my favourite song Shaun McCafferty.

In this Episode, I chat with Tina McCafferty about the atrocious attack on Israel by Hamas Terrorists over the weekend. We discuss the threats to the foundations of our global and national civilizations as a result of the systemic attacks on foundational principles and values. If you enjoy the episode, please consider sharing and commenting on it. --- Send in a voice message: https://podcasters.spotify.com/pod/show/restitch-america/message Support this podcast: https://podcasters.spotify.com/pod/show/restitch-america/support

The Bills look legit and Mccafferty is on the loose again!

Please visit answersincme.com/CKS860 to participate, download slides and supporting materials, complete the post test, and obtain credit. In this activity, an expert in nephrology discusses when to use SGLT2 inhibitors in patients with chronic kidney disease. Upon completion of this activity, participants should be better able to: Describe the benefits of SGLT2 inhibitor use in the management of CKD; Define strategies for the early implementation of SGLT2 inhibitor therapy in CKD; and Identify appropriate patient populations for the early implementation of SGLT2 inhibitor therapy in CKD.

Help us with our Juno research: https://forms.gle/12mhRWTFMBQ1ygkC7 I remember some time back in 2015, clicking around the additional objects on astro.com and discovering asteroid Juno who happened to be sandwiched right between my tight Mercury–Venus conjunction. Of course I was intrigued, but I was deep in the throes of a Pluto transit, so I had limited focus for distractions at that time. Recently by chance, I got talking to today's guest: Lianne McCafferty, about her peacock-inspired workspace – relevant for me over recent months as my little boy and I have been obsessed with them! We regularly have to visit the local “beegogs” as he so adorably puts it.   Turns out peacocks are associated with Juno! Just magical. Leanne has been fascinated with Juno since 2019/20 and has done a great deal of research which she is kindly sharing with us today. Like Venus and Jupiter, Leanne believes Juno to have benefic qualities which is no surprise as Juno is the wife of Jupiter. She is also known as Hera in Greek Mythology: long-suffering and committed wife of nymph-chasing serial-adulterer Zeus.  But Juno is about so much more than relationships – she impacts not only on a personal level, but social and mundane levels too, due to the speed, location and elliptical orbit of this fascinating asteroid.   ➡️ Where is Juno in your chart and can you relate to any of the areas we've covered today?   BIO Lianne McCafferty D.M.S. Astrol, MAPAI holds the Mayo Diploma (Distinction) in Natal & Mundane. In addition to tutoring, consulting, lecturing and writing, with articles published in the likes of the AA and NCGR Journals, as a former professional sportsperson & coach and now Black Belt 1st Dan in Shotokan Karate, the use of astrology to help enhance sport performance is of particular interest. https://liannemccafferty.com/ TIMESTAMPS 00:00:03 Intro 00:02:14 Lianne's Discovery of Juno 00:03:59 Lianne's Juno return 00:04:38 Lockdown revelations 00:10:53 Juno's speed, orbit & retrograde motion 00:14:37 Juno Mythology 00:17:44 Political Optome-TORY/partygate 00:21:12 Recent Mundane Events/Air Age 00:25:59 Glyph & Discovery chart 00:28:38 Juno Curitis: Warrior 00:29:05 Juno Sospita: Protector 00:31:07 Greek Myth: Hera 00:33:37 Lilith & Juno 00:39:42 Juno Moneta: Psychic accountant 00:43:33 Juno's Pattern 00:44:17 Juno Regina: Queen Consort 00:49:04 Patron saint of anniversaries 00:50:51 Juno Lucina: Midwife 01:03:25 Juno Natally 01:11:44 Sacrificing Lilith 01:15:30 Republic of Afghanistan 01:18:53 Fall of Kabul 01:34:05 Taiwan 01:35:18 Communist China 01:43:22 Aung San Suu Kyi - Burmese political leader/activist 01:50:16 Wrap up 01:52:10 Prize Draw   CHARTS Juno Discovery chart 01/09/1804, 22.00 pm, Lilienthal, Germany. Republic of Afghanistan 17/07/1973, 00.00, Kabul, Afghanistan Fall of Kabul 15/08/2021, 20.55, Kabul, Afghanistan China Communist 01/10/1949, 15.15, Peking, China Taiwan 01/01/1912, 00.00, Nanjing (Nanking), China Aung San Suu Kyi (Burmese political leader/activist) 19/06/1945, 12.00, Yangon, Myanmar (Burma)   LINKS Watch this episode: https://youtu.be/SCnsXEbYAVs Help us with our Juno research: https://forms.gle/12mhRWTFMBQ1ygkC7 Juno discovery chart https://www.astro.com/astro-databank/Celestial:_Juno_Discovery Astrological asteroid Juno https://www.astro.com/astrowiki/en/Juno Juno mythology https://en.wikipedia.org/wiki/Juno_(mythology) Astronomical asteroid Juno https://en.wikipedia.org/wiki/3_Juno Wild Swans https://en.wikipedia.org/wiki/Wild_Swans Monks Astrology  https://www.monksastrology.com/ Lianne McCafferty https://liannemccafferty.com/ #juno #asteroidjuno #peacock #hera #zeus #jupiter  

Kieran McCafferty, MB BChir, MRCP, MD (res) / Shelley Zieroth, MD, FRCPC, FHFSA (hon) - Handling Hyperkalaemia Without Compromising Care for Chronic Kidney Disease and Heart Failure

Talking crab cakes, steaks and Colts memories with Don McCafferty at The Beaumont The post Talking crab cakes, steaks and Colts memories with Don McCafferty at The Beaumont first appeared on Baltimore Positive WNST.

Kieran McCafferty, MB BChir, MRCP, MD (res) / Shelley Zieroth, MD, FRCPC, FHFSA (hon) - Handling Hyperkalaemia Without Compromising Care for Chronic Kidney Disease and Heart Failure

Kieran McCafferty, MB BChir, MRCP, MD (res) / Shelley Zieroth, MD, FRCPC, FHFSA (hon) - Handling Hyperkalaemia Without Compromising Care for Chronic Kidney Disease and Heart Failure

Today's guest comes from a great lineage of track and track coaches; his grandpa was the Massachusetts 600yd state champion and his father was also the Massachusetts 600yd state champion as well as running for the great Jumbo Elliott at Villanova and an extremely successful coaching career. Sean's own career has been cut short on the athletic side and grown tremendously on the coaching side. He sits down with us this week to talk about his career, how teaching Latin at CBA is his 'real job', and gives us great insights from the high school coaching perspective regarding collegiate recruitment. Oh and you're gonna want to hear about his 'Thursday Night Coach's Social', trust us! WATCH ON YOUTUBE   Want to have an exploratory conversation about YOUR track equipment needs? Connect with us: Host Mike Cunningham on Twitter: @mikecunningham Email: sales@gillathletics.com Phone: 800-637-3090 Twitter: @GillAthletics Instagram: @GillAthletics1918 Facebook: facebook.com/gillathletics LinkedIn: linkedin.com/company/gillathletics/

Supporting Women in Menopause in the Workplace. In an ideal workplace, every employee would have the necessary resources and support to comfortably navigate their personal and professional life, including their health and wellness needs. One area where help is vital for many employees is menopause, a natural biological process that often brings about physical and emotional challenges. By addressing the challenges of menopause, companies can help to create a supportive and inclusive environment for everyone. This, in turn, helps to enhance overall productivity, employee satisfaction, and workplace retention rates. My special guest is Hatty McCafferty a highly experienced certified menopause consultant and coach who has dedicated her career to providing support and guidance for midlife women navigating the challenges of menopause in the workplace. As the host of the popular podcast Real Menopause Talk, Hatty has cultivated a wealth of knowledge and understanding of the complexities surrounding menopause and its impact on individuals and organizations. With a background as a 500-hour Hatha yoga instructor, personal trainer, and nutrition coach, she offers a holistic approach to menopause management that empowers both women and their supporters. Hatty's passion for breaking down stigmas and initiating essential conversations in the workplace makes her an invaluable resource for midlife women everywhere. In this podcast episode, Hatty McCafferty points out the significance of starting conversations about menopause in the workplace. This includes breaking down the basics of biology and addressing the concerns and challenges women face going through this stage of life. Hatty emphasizes the need for companies to recognize the importance of supporting and embracing the experiences of midlife women by providing resources and creating a comfortable environment, which ultimately leads to a better work-life balance. Hatty McCafferty Bio: Hatty is a certified Menopause Consultant with a unique ability to unify people from C-suite to most junior with her energy, authenticity, and humor. Having interviewed more than 100 people for her award-winning podcast, she supports all genders along the Perimenopause transition with a natural aptitude for including men in the conversation. Her strong background in TV and global experience teaching fitness makes her the perfect speaker and host inspiring clear communication, meaningful connection, and confidence. Hatty delivers simple, accessible strategies that boost the well-being of mind and body. Hatty has lived in Europe and the Caribbean and is well-versed in cultural differences. Her respectful, inclusive delivery ensures that everyone leaves uplifted. Get full show notes and more information here: https://elizabethsherman.com/podcast/120  

Elizabeth Mcafferty is an actress and journalist, she has starred in Hitman's Bodyguard (2017), The Nutcracker and the Four Realms (2018) and Dumbo (2019) and her work has been published in VICE, The Guardian, Dazed and The Independent. We talked to Elizabeth about getting into acting via body doubling, approaching stories with compassion and seeking out the stranger stories in life.  PLUS extra chat with Elizabeth over at patreon.com/blankpodcast Massive thanks to our Patrons: Mary Catherine Byrnes, Victoria Nielsen, Manya Kay, Alex Williams, Joel Piveteau, Richard Astill, Samantha Beaton, Claudia McKelvey, John Holland, Katherine Keen, Lynn Robinson, It's Coming Home 2022, Alice Chrystall, Maddie Lightfoot, Alex Collis, Martin Grimm, Vicki, Julianna Williams, Rachel Bowen, Witnessthebigness. @blankpod @eliistender @jimdalycomedy @elizabethmccaff blankpodcast2018@gmail.com

The racial wealth gap is the topic of the latest Crain's Forum section. Assistant editor Rachel Abbey McCafferty joined The Landscape to share what she found about the causes behind these disparities and the importance of narrowing them. This episode of the Landscape is sponsored by Delta Dental of Ohio. With offices in Cleveland, Cincinnati and Dublin, Delta Dental of Ohio is proud to be an industry leader in dental benefits. Together with their customers, providers and employees, Delta Dental of Ohio builds a higher standard of oral health care in Ohio communities. Delta Dental of Ohio also works with entrepreneurs, innovators and change-makers who are committed to improving the health and wellbeing of all Buckeyes. Together, they are building healthy, smart, vibrant communities for all. For more information, visit deltadentaloh.com.

  Direct Download Bing takes a break from teaching at the John C. Campbell Folk School to record an improvisation on his new McCafferty mountain dulcimer. Bing Futch is endorsed by Folkcraft Instruments, V-Picks and Zither Stands. Enjoy "Dulcimerica"? Consider supporting the program by becoming a patron!

In this episode we are grateful to welcome Lorri McCafferty! Lorri is an Intuitive Healer, who provides several Healing Modalities, including but not limited to, Tarot Readings, Crystal Healing and […]

Hey here we go… Episode 110 – Gerber, Danko and Chuck get together for some late night sports talking about Super Bowl 57 and a great week of sports in the Land. The Guys start in Glendale Arizona moments after the exciting and controversial end of the Super Bowl. The Guys break down keys to the Chiefs big win, things they get wrong the week before and who has the best chance to be back next year. The Guys also discuss their sports betting/raise money for the show plan that didn't go great before looking ahead to next year and the Betstamp Best Bet to win Super Bowl 58. Moving on (18:53), the Guys leave the desert and head back to the Land to talk a big week in Cleveland sports. The Guys start with a recap of a perfect week of basketball for the Cavs built on defense, bigs and toughness. The Guys also take a moment to honor Browns legend Joe Thomas and his election to the NFL Hall of Fame and look at the possibility that any active player can catch the brand-new NBA scoring king, LeBron James. Off the field and on the eve of Valentine's day (37:55), the Guys take some time to talk about Love. Best love songs, best romantic sports movies, missed opportunities for love, love language and support from their spouses and significant others have the guys feeling romantic… sort of… Stick around for the outtakes and thoughts on the Super Bowl Halftime show. Errors: Chuck referenced a guy named “McCafferty” when discussing the San Francisco 49ers. We are pretty sure he was talking about Christian McCaffery. But, its possible he was talking about the band McCafferty and their recent release Snoqualmie Welcomes You. From the Land is brought to you by @betstamp your one stop for all the best betting lines From the Land is available on Twitter @Pod_FromtheLand, on Instagram @fromthelandpodcast, on YouTube @fromtheland and the world wide web at www.fromthelandpodcast.com

"Dan McCafferty Remembered" Okay, to be fair Dan McCafferty left the legendary Scottish band back in 2013 but worthy replacements aside, he will always be the voice of Nazareth. After 45 years fronting the internationally acclaimed outfit, McCafferty stepped aside due to health reasons. Recharged, revitalized and sounding better than ever, McCafferty roared back with The Last Testament, his third solo album--and first since 1987. In this conversation he chats with Alex about his collaboration with the Czech instrumentalist Karel Marik, why he's never planned anything in his life and why the easiest people to talk to are fishermen.

McCafferty Ranch are a family owned and operated cattle ranch in Central Montana owned by Joel and Cindy McCafferty (the 3rd, 4th, and 5th generations are all living on the ranch).  In 2014, Joel and Cindy's daughter Megan (and husband Logan) moved back to the ranch, and the need to diversify the ranch's income arose.  Joel had seen hydroponics used by a friend to maintain his bull herd.  When he saw this, he immediately started thinking about how he could feed out beef cattle on barley sprouts.  After some research (although there was very limited research on the topic at the time) they jumped all in and built a hydroponic plant on the ranch. The plant was designed and built by members of the family in 2017, and they started feeding cattle on barley sprouts for direct to consumer sales.   Their mission from the get go was to produce the healthiest and best tasting beef possible.  They feel as if they have accomplished that.  All of their beef cattle are born and raised on their ranch.  They practice gentle cattle handling from birth to processing by doing all of their cattle work on horseback.   Finally, the beef is finished on barley sprouts.  The barley fodder has allowed their cattle to gain weight extremely well (comparable to grain finished beef) and to marble extremely well (comparable to grain finished beef).  They often tell potential customers that the barley sprouts allow their animals to gain weight much like an athlete would - through a healthy diet and exercise (their animals are fed out in a large pasture where they are required to walk distances to feed, graze and water). These health benefits are translated into the beef product. Currently they sell beef direct to consumers through nationwide sales and bulk local orders.  Additionally, they have recently started producing beef tallow products such as soaps, lotions, and leather conditioners that are 100% non-toxic and really allow them to utilize the whole animal. They have also redesigned their hydroponic plant and manufactured an entirely new hydroponic system that is now available to purchase. This new hydroponic system is unlike any other on the market and they believe superior because of production ability, state of the art automations, and lower price points than competitors.  They could go on and on about the applications for hydroponics within the ag industry and believe that it could really change agriculture for the better. https://www.mccaffertyranch.com/ https://www.instagram.com/mccaffertyranchbeef/ Timestamps 00:00 Introduction 04:15 Hydroponics 07:50 Sprouts as finishing ration 12:55 USDA grading system 15:13 Water used for producing sprouts 17:51 Herbicides, pesticides 19:37 Temperature 23:42 Just water and barley 26:53 Acreage 32:56 Drought in Montana 38:07 Limitations to scaling 43:59 Metabolomic analysis of beef 49:36 Feeding hydroponic sprouts to beef See open positions at Revero: https://jobs.lever.co/Revero/ Join Carnivore Diet for a free 30 day trial: https://carnivore.diet/join/ Book a Carnivore Coach: https://carnivore.diet/book-a-coach/ Carnivore Shirts: https://merch.carnivore.diet Subscribe to our Newsletter: https://carnivore.diet/subscribe/ . ‪#revero #shawnbaker #Carnivorediet #MeatHeals #HealthCreation   #humanfood #AnimalBased #ZeroCarb #DietCoach  #FatAdapted #Carnivore #sugarfree  ‪