Let's talk e-cigarettes

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Steve Cook from the University of Michigan USA about the importance of correctly interpreting and assessing the available data. Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Dr Steven Cook from the Department of Epidemiology, School of Public Health University of Michigan and the Centre for Assessment of Tobacco Regulations, University of Michigan. In the May podcast Steve Cook discusses the methodological problems of cross-sectional data on the health effects of e-cigarette use a topic he addressed at the May 2025 EC Summit, Washington DC. Steve Cook underlines why all cross-sectional health effects studies should be interpreted with extreme caution unless they examine dose-response relationships and account for temporality and cigarette smoking confounding. Dr Cook emphasises the importance of other information such as smoking histories and health histories and the importance of developing a best practice to ensure that we minimize the risks associated with spurious association and maximise predictive accuracy. Steven Cook receives National Institute for Health (NIH) and Food and Drug Administration's (FDA) Center for Tobacco Products (CTP) funding. This is not deemed a conflict of interest. EC Summit, Washington DC: https://www.e-cigarette-summit.com/program-2025/ Recent paper: 10.1016/j.isci.2025.111985 This podcast is a companion to the electronic cigarettes Cochrane living systematic review and Interventions for quitting vaping review and shares the evidence from the monthly searches. Our search for the EC for smoking cessation review carried out on 1st May 2025 found 1 ongoing (NCT06922617) and 1 linked study (DOI: 10.1101/2025.02.17.25322409). Our search for our interventions for quitting vaping review up to 1st May 2025 found 1 new (DOI 10.1001/jama.2025.3810) and 4 ongoing studies (DOI 10.2196/71961, KCT0010346, NCT06909500, NCT06929520). For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review of E-cigarettes for smoking cessation updated in January 2025 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub9/full For more information on the full Cochrane review of Interventions for quitting vaping published in January 2025 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD016058.pub2/full This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson explore new e-cigarette research and speak with Eden Evins from Massachusetts General Hospital and Harvard Medical School, about her randomized clinical trial on varenicline for youth vaping cessation. Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Professor Eden Evins from Massachusetts General Hospital and Harvard Medical School, Boston. In the April podcast Eden Evins discusses the findings of their new randomised clinical trial to evaluate the efficacy of varenicline for nicotine vaping cessation in 261 treatment seeking youth (16-24 years) who do not smoke tobacco regularly. This study has just been published in JAMA, April 2025 (DOI:10.1001/jama.2025.3810 NCT05367492). Professor Evins describes her interest in the high use of vapes among young people and the speed at which this increase to a different flavoured form of nicotine has occurred. Professor Evins and her team thought that varenicline, a pill based drug that is used for quitting smoking, could work for vaping cessation. She talks about the huge demand to take part in the study and how the team had to pause recruitment to keep up. She describes how young people were indignant, they had not expected to become addicted. Professor Evins says that when young people found they couldn't sit through a study session without needing to vape they were surprised and felt taken advantage of by marketers and these flavored products that they had thought were for fun. Their study funded by the National Institutes of Health in the US shows that the continuous abstinence rates in the last month of treatment (51% vs 14%) and at 6-month follow-up (28% vs 7%) are higher in the varenicline group than in the placebo group. This was a 12-week trial with 6 month follow up. Treatment-emergent adverse events did not differ significantly between groups. In summary varenicline, when added to brief cessation counselling, is well tolerated and promotes nicotine vaping cessation compared with placebo in youth with addiction to vaped nicotine. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and Interventions for quitting vaping review and shares the evidence from the monthly searches. Our search for the EC for smoking cessation review carried out on 1st April 2025 found 1 new ongoing study (NCT06789692) and 5 linked papers. Our search for our interventions for quitting vaping review up to 1st April 2025 found 3 new ongoing studies (NCT06862050; TCTR20250203006; NCT06885606), For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review of E-cigarettes for smoking cessation updated in January 2025 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub9/full For more information on the full Cochrane review of Interventions for quitting vaping published in January 2025 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD016058.pub2/full This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Monserrat Conde from the University of Oxford. Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Dr Monserrat Conde from the Nuffield Department of Primary Care Health Sciences, University of Oxford. In the March podcast Monserrat Conde discusses the findings of the recent systematic review of electronic cigarettes and subsequent smoking in young people and an evidence and gap map. The systematic review aims to assess the evidence for a relationship between the use of e-cigarettes /vapes and subsequent smoking in young people under 30, and whether this differs by demographic characteristics. There is very low certainty evidence suggesting that e-cigarette use and availability are inversely associated with smoking in young people (i.e. as e-cigarettes become more available and/or are used more widely, youth smoking rates go down or, conversely, as e-cigarettes are restricted, youth smoking rates go up). At an individual level, people who vape appear to be more likely to go on to smoke than people who do not vape; however, it is unclear if these behaviours are causally linked. Monserrat discusses the differences in the information coming from the population studies compared to the individual level studies and notes that most studies are from high income countries, in particular from the US. To see the full review: https://doi.org/10.1111/add.16773 This podcast is a companion to the electronic cigarettes Cochrane living systematic review and Interventions for quitting vaping review and shares the evidence from the monthly searches. Our literature searches for the EC for smoking cessation review carried out on 1st March 2025 found 1 new study (DOI: 10.1016/j.drugalcdep.2024.112271), one new ongoing study (ACTRN12625000179437) and two records linked to studies included in the review. Our literature searches for the interventions for quitting vaping review carried out on 1st March 2025 found 2 new ongoing studies (NCT06832098, ACTRN12625000143426) and four records linked to studies included in the review. For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review of E-cigarettes for smoking cessation updated in January 2025 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub9/full For more information on the full Cochrane review of Interventions for quitting vaping published in January 2025 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD016058.pub2/full This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Olivier Drouin from the University of Montreal, Canada. Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Dr Olivier Drouin. Dr Olivier Drouin is a Clinical Assistant Professor in both the Department of Paediatrics and Department of Social and Preventive Medicine at Université de Montréal. In the February podcast Olivier Drouin discusses his ongoing pilot randomized trial of a brief digital screening and intervention tool for parental and adolescents to address tobacco and electronic cigarette use, CanCEASE. This study takes place in paediatric medical care settings in Canada and is funded by the Canadian Institutes of Health Research. Their pilot study aims to demonstrate the feasibility and evaluate the preliminary effectiveness of the CEASE program for parental smoking cessation and its adapted version for adolescent smoking cessation and adolescent and parental vaping cessation. There is a strong need for effective and cost-effective smoking and vaping cessation interventions for parents and adolescents. If successful, this study will help inform the preparation of a fully powered randomized controlled trial of CEASE in Canada in these populations. Olivier Drouin discusses the importance of behavioural science in understanding the drivers of behaviour and health behaviour change, including the use of scientific method to understand rational and irrational behaviours, habit formation and the role of peer pressure and social norms. The pilot study discussed in this podcast by Chadi at al 2023 is DOI: https://dx.doi.org/10.2196/47978; NCT05366790. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and Interventions for quitting vaping review and shares the evidence from the monthly searches. Our literature searches for the EC for smoking cessation review carried out on 1st February 2025 found 2 new studies (Ikonomidis 2024 DOI: 10.1093/eurheartj/ehae666.3388; Kouroutzoglou 2024 DOI: 10.1093/eurheartj/ehae666.2955) and 6 papers linked to studies included in our review. Our catch-up search for our interventions for quitting vaping review up to 1st February 2025 found 7 new ongoing studies and 4 linked papers. For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review of E-cigarettes for smoking cessation updated in January 2025 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub9/full For more information on the full Cochrane review of Interventions for quitting vaping published in January 2025 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD016058.pub2/full This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and talk about the findings of their newly published Cochrane review of interventions for quitting vaping. Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research. Jamie and Nicola share the findings of their new Cochrane review of interventions for quitting vaping published in January 2025 and funded by Cancer Research UK (https://doi.org/10.1002/14651858.CD016058.pub2). This new review included nine studies in just over 5,000 participants. Studies tested nicotine replacement therapy, cytisine, varenicline, nicotine/vaping reduction and text message-based interventions. The review found that text-message-based interventions may help young people to stop vaping and that varenicline may help people to stop vaping when compared to no or minimal support. There was some promising evidence from a shorter study of cytisine. More information is needed on other interventions, on potential harms and on the effect on use of tobacco cigarettes. Twenty ongoing studies looking at a range of interventions were identified in the review. The motivation for the review and the press coverage is also discussed. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and Interventions for quitting vaping review and shares the evidence from the monthly searches. Our literature searches for the EC for smoking cessation review carried out on 1st December and 1st January found 3 new studies (Kale 2024 DOI 10.1101/2024.09.13.24313612; Pericot-Valverde 2024 DOI 10.1093/ntr/ntae260; Sifat 2024 DOI 10.1016/j.dadr.2024.100295) and 3 linked studies (DOIs 10.1016/j.heliyon.2024.e39695; 10.1111/add.16698; 10.1093/ntr/ntae223) For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review of E-cigarettes for smoking cessation updated in January 2024 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub8/full For more information on the full Cochrane review of Interventions for quitting vaping published in January 2025 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD016058.pub2/full This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Marathi Vojjala from New York University, Global Institute of Public Health, USA. Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Dr Marathi Vojjala from the Global Institute of Public Health, New York University, USA. In the November podcast Marathi Vojjala discusses her pilot randomised controlled trial (RCT) that aims to investigate the effects of switching to electronic cigarettes from combustible cigarettes and the potential acceptability of e-cigarettes or as a harm reduction strategy among individuals with chronic diseases who smoke. This study examines examining the potential of behavioural counselling paired with e-cigarettes versus nicotine replacement therapy (e.g. nicotine patches or gum) for achieving harm reduction and decreased combustible cigarette use. The findings from this pilot RCT hold significant implications for chronic conditions such as COPD, asthma, CAD, and peripheral arterial disease who smoke combustible cigarettes. The observed reduction in CPD and improvement in respiratory symptoms suggest that switching to e-cigarettes appears feasible and acceptable among those with chronic diseases. These results suggest that e-cigarettes may offer an alternative for individuals struggling to quit combustible cigarette smoking through existing pharmacotherapies. This study supports further exploration of switching to e-cigarettes as a harm reduction strategy among combustible cigarette users who have been unsuccessful at quitting by other means. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. Our literature searches carried out on 1st November found 1 new ongoing study (NCT06614504) & 2 linked papers (DOIs: 10.1111/dar.13953 & 10.1001/jamainternmed.2024.5196) For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review updated in January 2024 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub8/full This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Marathi Vojjala from New York University, Global Institute of Public Health, USA. Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Dr Marathi Vojjala from the Global Institute of Public Health, New York University, USA. In the November podcast Marathi Vojjala discusses her pilot randomised controlled trial (RCT) that aims to investigate the effects of switching to electronic cigarettes from combustible cigarettes and the potential acceptability of e-cigarettes or as a harm reduction strategy among individuals with chronic diseases who smoke. This study examines examining the potential of behavioural counselling paired with e-cigarettes versus nicotine replacement therapy (e.g. nicotine patches or gum) for achieving harm reduction and decreased combustible cigarette use. The findings from this pilot RCT hold significant implications for chronic conditions such as COPD, asthma, CAD, and peripheral arterial disease who smoke combustible cigarettes. The observed reduction in CPD and improvement in respiratory symptoms suggest that switching to e-cigarettes appears feasible and acceptable among those with chronic diseases. These results suggest that e-cigarettes may offer an alternative for individuals struggling to quit combustible cigarette smoking through existing pharmacotherapies. This study supports further exploration of switching to e-cigarettes as a harm reduction strategy among combustible cigarette users who have been unsuccessful at quitting by other means. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. Our literature searches carried out on 1st November found 1 new ongoing study (NCT06614504) & 2 linked papers (DOIs: 10.1111/dar.13953 & 10.1001/jamainternmed.2024.5196) For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review updated in January 2024 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub8/full This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Stephen Higgins from the University of Vermont Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Professor Stephen Higgins from the University of Vermont Tobacco Center of Regulatory Science, Burlington, USA. Professor Stephen Higgins uses the concepts and methods of behavioural economics and behavioural pharmacology to investigate tobacco, illicit drugs, and other health-related risk behaviours in vulnerable populations. In the October podcast Stephen Higgins describes his recent studies on reduced nicotine cigarettes and e-cigarettes in high-risk populations. Their three randomised clinical trials involved 326 participants. They found that decreases in cigarettes smoked daily, resulting from smoking cigarettes with reduced nicotine content, were significantly larger when adults from at-risk populations had access to e-cigarettes in their preferred flavours. Their study findings indicate that access to preferred flavoured e-cigarettes has the potential to enhance the effect of a nicotine-reduction policy on cigarette smoking in populations with psychiatric conditions or lower education level who are at greatest risk for smoking and associated harm. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. Our literature searches carried out on 1st October found: 2 new studies. The study by Higgins et al described on this podcast (DOI: 10.1001/jamanetworkopen.2024.31731) and DOI: 10.1093/ntr/ntae212. We also found 3 linked papers (10.2196/58260, 10.1111/add.16633, 10.1038/s41415-024-7850-5) For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review updated in January 2024 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub8/full This podcast is supported by Cancer Research UK

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Benjamin Toll, Medical University of South Carolina Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Professor Benjamin Toll, Medical University of South Carolina about his work and interventions to help people to quit vaping. Professor Benjamin Toll is a clinical psychologist, a professor of Public Health Sciences and Psychiatry, Co-Director of the Lung Cancer Screening Program, and Chief of Tobacco Cessation and Health Behaviors at the Hollings Cancer Center, and Director of the Tobacco Treatment Program at the Medical University of South Carolina. Ben Toll specialises in treatment of tobacco use disorders, alcohol use disorders, and improvement of health behaviours. In the September podcast Ben Tol describes how he became involved in this research field, about his smoking cessation work and about interventions to help people to quit vaping. Ben discusses some pilot studies of vaping cessation with Amanda Palmer and a study of varenicline for vaping cessation with Lisa Fucito. Ben talks about the importance of creating an evidence base to inform clinical practice guidelines for quitting vaping. At present there are very few studies looking at vaping cessation and Ben stresses the need for more studies in this field. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. Our literature searches carried out on 1st August & 1st September found: 1 new study (10.1093/ntr/ntae158), 5 new ongoing studies (DOI: 10.51847/c5AEETRrY9; DOI: 10.1186/s13722-024-00483-5; NCT06534905; NCT06543407; NCT06554873 ) & 3 linked papers. For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review updated in January 2024 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub8/full This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Benjamin Toll, Medical University of South Carolina Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Professor Benjamin Toll, Medical University of South Carolina about his work and interventions to help people to quit vaping. Professor Benjamin Toll is a clinical psychologist, a professor of Public Health Sciences and Psychiatry, Co-Director of the Lung Cancer Screening Program, and Chief of Tobacco Cessation and Health Behaviors at the Hollings Cancer Center, and Director of the Tobacco Treatment Program at the Medical University of South Carolina. Ben Toll specialises in treatment of tobacco use disorders, alcohol use disorders, and improvement of health behaviours. In the September podcast Ben Tol describes how he became involved in this research field, about his smoking cessation work and about interventions to help people to quit vaping. Ben discusses some pilot studies of vaping cessation with Amanda Palmer and a study of varenicline for vaping cessation with Lisa Fucito. Ben talks about the importance of creating an evidence base to inform clinical practice guidelines for quitting vaping. At present there are very few studies looking at vaping cessation and Ben stresses the need for more studies in this field. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. Our literature searches carried out on 1st August & 1st September found: 1 new study (10.1093/ntr/ntae158), 5 new ongoing studies (DOI: 10.51847/c5AEETRrY9; DOI: 10.1186/s13722-024-00483-5; NCT06534905; NCT06543407; NCT06554873 ) & 3 linked papers. For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review updated in January 2024 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub8/full This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Benjamin Toll, Medical University of South Carolina Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Professor Benjamin Toll, Medical University of South Carolina about his work and interventions to help people to quit vaping. Professor Benjamin Toll is a clinical psychologist, a professor of Public Health Sciences and Psychiatry, Co-Director of the Lung Cancer Screening Program, and Chief of Tobacco Cessation and Health Behaviors at the Hollings Cancer Center, and Director of the Tobacco Treatment Program at the Medical University of South Carolina. Ben Toll specialises in treatment of tobacco use disorders, alcohol use disorders, and improvement of health behaviours. In the September podcast Ben Tol describes how he became involved in this research field, about his smoking cessation work and about interventions to help people to quit vaping. Ben discusses some pilot studies of vaping cessation with Amanda Palmer and a study of varenicline for vaping cessation with Lisa Fucito. Ben talks about the importance of creating an evidence base to inform clinical practice guidelines for quitting vaping. At present there are very few studies looking at vaping cessation and Ben stresses the need for more studies in this field. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. Our literature searches carried out on 1st August & 1st September found: 1 new study (10.1093/ntr/ntae158), 5 new ongoing studies (DOI: 10.51847/c5AEETRrY9; DOI: 10.1186/s13722-024-00483-5; NCT06534905; NCT06543407; NCT06554873 ) & 3 linked papers. For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review updated in January 2024 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub8/full This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Benjamin Toll, Medical University of South Carolina Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Professor Benjamin Toll, Medical University of South Carolina about his work and interventions to help people to quit vaping. Professor Benjamin Toll is a clinical psychologist, a professor of Public Health Sciences and Psychiatry, Co-Director of the Lung Cancer Screening Program, and Chief of Tobacco Cessation and Health Behaviors at the Hollings Cancer Center, and Director of the Tobacco Treatment Program at the Medical University of South Carolina. Ben Toll specialises in treatment of tobacco use disorders, alcohol use disorders, and improvement of health behaviours. In the September podcast Ben Tol describes how he became involved in this research field, about his smoking cessation work and about interventions to help people to quit vaping. Ben discusses some pilot studies of vaping cessation with Amanda Palmer and a study of varenicline for vaping cessation with Lisa Fucito. Ben talks about the importance of creating an evidence base to inform clinical practice guidelines for quitting vaping. At present there are very few studies looking at vaping cessation and Ben stresses the need for more studies in this field. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. Our literature searches carried out on 1st August & 1st September found: 1 new study (10.1093/ntr/ntae158), 5 new ongoing studies (DOI: 10.51847/c5AEETRrY9; DOI: 10.1186/s13722-024-00483-5; NCT06534905; NCT06543407; NCT06554873 ) & 3 linked papers. For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review updated in January 2024 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub8/full This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research interview Jamie Brown, University College London Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Professor Jamie Brown. Jamie Brown is Professor of Behavioural Science and Director of the Tobacco and Alcohol Research Group at University College London. He co-leads a research programme that aims to provide insights into population-wide influences on smoking, smoking cessation and alcohol reduction via management and analysis of the major population surveys, the Smoking and Alcohol Toolkit Study. He is also involved in the development of digital behaviour change technologies. His particular focus is on real-world monitoring and evaluation of national tobacco control and alcohol policies, events and stop smoking treatments including e-cigarettes and nicotine replacement therapy. In this podcast Jamie describes how he became involved in this research field. Jamie talks about the national surveillance programme, the Smoking Toolkit Study in relation to e-cigarettes. The Smoking Toolkit Study aims to monitor trends and provide insights into population wide influences on smoking and smoking cessation and be representative of adults in Great Britain. Each month a new sample of about 2400 adults complete a detailed survey with a trained Ipsos Mori interviewer. The study was started by Professor Robert West, almost 20 years ago in 2006 and has accumulated data from almost 400,000 different adults. This is an open toolkit or resource and the data is intended to be used by other researchers, policy makers and practitioners. Jamie talks about the different kinds of information that can be gathered from surveys compared to randomized controlled trials and discusses the importance of gathering data from different sources, to enhance the credibility of research findings. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. Our literature searches carried out on 1st July found: found 2 new studies (DOI:10.1001/jamainternmed.2024.1822; DOI: 10.1158/1538-7445.AM2024-LB086), 1 new ongoing study (NCT03862924) & 4 linked papers. For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review updated in January 2024 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub8/full This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research interview Jamie Brown, University College London Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Professor Jamie Brown. Jamie Brown is Professor of Behavioural Science and Director of the Tobacco and Alcohol Research Group at University College London. He co-leads a research programme that aims to provide insights into population-wide influences on smoking, smoking cessation and alcohol reduction via management and analysis of the major population surveys, the Smoking and Alcohol Toolkit Study. He is also involved in the development of digital behaviour change technologies. His particular focus is on real-world monitoring and evaluation of national tobacco control and alcohol policies, events and stop smoking treatments including e-cigarettes and nicotine replacement therapy. In this podcast Jamie describes how he became involved in this research field. Jamie talks about the national surveillance programme, the Smoking Toolkit Study in relation to e-cigarettes. The Smoking Toolkit Study aims to monitor trends and provide insights into population wide influences on smoking and smoking cessation and be representative of adults in Great Britain. Each month a new sample of about 2400 adults complete a detailed survey with a trained Ipsos Mori interviewer. The study was started by Professor Robert West, almost 20 years ago in 2006 and has accumulated data from almost 400,000 different adults. This is an open toolkit or resource and the data is intended to be used by other researchers, policy makers and practitioners. Jamie talks about the different kinds of information that can be gathered from surveys compared to randomized controlled trials and discusses the importance of gathering data from different sources, to enhance the credibility of research findings. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. Our literature searches carried out on 1st July found: found 2 new studies (DOI:10.1001/jamainternmed.2024.1822; DOI: 10.1158/1538-7445.AM2024-LB086), 1 new ongoing study (NCT03862924) & 4 linked papers. For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review updated in January 2024 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub8/full This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research interview Louise Ross from the National Centre for Smoking Cessation and Training (NCSCT). Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Louise Ross from the National Centre for Smoking Cessation and Training (NCSCT). Louise Ross has worked in smoking cessation for over 20 years and consults for the NCSCT, and is part of the senior team on the Smoke Free App, a digital service for helping people stop smoking. NCSCT is a social enterprise committed to supporting the delivery of effective evidence-based tobacco control programmes and smoking cessation interventions provided by local stop smoking services, and by colleagues in the NHS and the social care sector. For further information about NSCST: https://www.ncsct.co.uk/ Louise Ross talks about the swap to stop scheme that aimed to reach a million people who smoke to give them a chance to switch less harmful vapes. The swap to stop training is not only for qualified stop smoking practitioners but is also aimed at the frontline services working with for example debt management teams within social housing, homelessness, substance use, and other groups. The training models how to raise the subject of quitting smoking and swap to stop. A four week supply of e-liquid is provided and, if funds are available, a 12 week supply. People are advised how much they should use their vape and to use an e-liquid that is strong enough to manage their withdrawal symptoms, as they would be with nicotine replacement therapy. They are also advised not to stop using a vape too soon as they may go back to tobacco smoking. Jamie and Nicola discuss ongoing work on brief opportunistic advice in financial support settings. The scoping review mentioned is available here: https://onlinelibrary.wiley.com/doi/full/10.1111/add.16533 This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. Our literature searches carried out on 1st June found: One linked study: Leavens E.; Nollen N, Ahluwalia J, Mayo M, Rice M, Brett E, Pulvers K. Changes in dependence, withdrawal, and craving among adult smokers who switch to nicotine salt pod-based e-cigarettes, Journal of Clinical and Translational Science / 2021;5(Supplement 1):85-86, DOI: 10.1017/cts.2021.622 For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review updated in January 2024 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub8/full This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research interview Andrea Villanti. Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Associate Professor Andrea Villanti, Department of Health Behavior, Society, and Policy, Rutgers School of Public Health. Andrea Villanti's research focuses on young adult tobacco use including predictors and patterns of use and interventions to reduce tobacco use in young adults. Dr Villanti describes their randomised controlled trial to test the effect of three exposures to eight nicotine corrective messages on beliefs about nicotine, nicotine replacement therapy, e-cigarettes and reduced nicotine content cigarettes at 3-month follow-up. Their study concluded that repeated exposure to NCM was necessary to reduce false beliefs about nicotine and tobacco products and is reported in Tobacco Control e-publication, doi:10.1136/ tc-2023-058252. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. Our literature searches carried out on 1st May found: One new study by Rabenstein A et al, Implications of Switching from Conventional to Electronic Cigarettes on Quality of Life and Smoking Behaviour: Results from the EQualLife Trial. European Addiction Research / 2024;(c60, 9502920):1-9 Three new ongoing studies: NCT06372899; NCT06373679 and Polosa et al, Protocol for the "magnitude of cigarette substitution after initiation of e-cigarettes and its impact on biomarkers of exposure and potential harm in dual users" (MAGNIFICAT) study, Frontiers in Public Health / 2024;12(101616579):1348389, DOI 10.3389/fpubh.2024.1348389 For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review updated in January 2024 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub8/full This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research interview Jaqueline Avila. Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Professor Jaqueline Avila from the Department of Gerontology, University of Massachusetts Boston, USA. Professor Avila describes their pilot study to assesses the harm-reduction potential of e-cigarettes and oral nicotine pouches among people who smoke with low socioeconomic status. This pilot of 45 people provides novel evidence that e-cigarettes and nicotine pouches can be a harm-reduction tool for individuals with lower SES who smoke and are not willing to quit smoking, contributing to reducing tobacco-related disparities in this population. This study is funded by Brown University. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. Our literature searches carried out on 1st April found: Avila JC, Maglalang DD, Nollen N, Lee SC, Suh R, Malone M, Binjrajka U, Ahluwalia JS, Using pod based e-cigarettes and nicotine pouches to reduce harm for adults with low socioeconomic status who smoke: a pilot randomized controlled trial Nicotine & tobacco research 2024. 10.1093/ntr/ntae047. Featured in our podcast. Four papers linked to studies included in the review: Belderson et al 2024, DOI 10.1136/bmjopen-2023-078677; Liu et al, 2024, DOI 10.1001/jamainternmed.2024.1125; Yingst et al 2024, DOI 10.1136/tc-2023-058282; Conte et al 2024, DOI 10.2196/53222. Two new ongoing studies: NCT06264154 and NCT06260683 For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review updated in January 2024 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub8/full This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research interview Ian Pope. Associate Professor Jamie Hartmann-Boyce and Dr Nicola Lindson discuss the new evidence in e-cigarette research and interview Dr Ian Pope, an emergency medicine physician and honorary associate professor at Norwich Medical School, about his new trial, which he co leads with Professor Caitlin Notley from the University of East Anglia. The new trial is the COSTED trial, the Cessation of Smoking Trial in the Emergency Department and funded by the British National Institutes of Health Research. This is a multi-centre randomised controlled trial, based in 6 emergency departments around the UK. This study tested the real-world effectiveness of an emergency department based smoking cessation intervention that included provision of an e-cigarette starter kit compared to usual care. (ClinicalTrial.gov:NCT04854616). Adults who smoke tobacco and were attending one of six EDs across the UK were randomised to either control (in which case they were given written information about stop smoking services) or intervention (brief smoking cessation intervention, provision of an e-cigarette starter kit, and referral to stop smoking services). Both groups were followed up 1, 3 and 6 months after randomisation. Smoking abstinence was biochemically verified at 6 months. There were over a thousand participants and biochemically verified smoking cessation rate of 7.2% in the intervention group 4.1% in the control group. The study found that it was feasible to implement a smoking cessation intervention in EDs with dedicated staff time to deliver the intervention and that EDs may represent an excellent opportunity to engage hard to reach smokers. Pope I, Notley C, Boyle A, Results of the cessation of smoking trial in the emergency department (COSTED), Emergency Medicine Journal / 2023;40(12):873-874 This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. Our literature searches carried out on 1st March found the following 1 new study: Hoeppner BB, Eddie D, Schick M, Hoeppner SS, Kelly L, Kelly JF, Feasibility of and reactivity to ecological momentary assessment (EMA) during electronic cigarette use initiation in adults who smoke daily: MASKED FOR REVIEW, European Journal of Psychiatry / 2024;38(3):100247. 10.1016/j.ejpsy.2023.100247 3 papers linked to studies included in the review: Auer R, Schoeni A, Humair J-P, Jacot-Sadowski I, Berlin I, Stuber MJ, Haller ML, Tango RC, Frei A, Strassmann A, Bruggmann P, Baty F, Brutsche M, Tal K, Baggio S, Jakob J, Sambiagio N, Hopf NB, Feller M, Rodondi N, Berthet A, Electronic Nicotine-Delivery Systems for Smoking Cessation, The New England journal of medicine / 2024;390(7):601-610. 10.1056/NEJMoa2308815 Piper ME, Schlam TR, Donny EC, Kobinsky K, Matthews J, Piasecki TM, Jorenby DE, The Impact of Three Alternate Nicotine-Delivery Products on Combusted Cigarette Use: A Randomized Controlled Trial, Nicotine & Tobacco Research, 2024;, ntae014, 10.1093/ntr/ntae014 Correction to Yingst: Changes in Nicotine Dependence Among Smokers Using Electronic Cigarettes to Reduce Cigarette Smoking in a Randomized Controlled Trial, Nicotine & Tobacco Research, 2023;, ntad229, 10.1093/ntr/ntad229 For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review updated in January 2024 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub8/full This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research interview Reto Auer, Bern University, Switzerland. Associate Professor Jamie Hartmann-Boyce and Dr Nicola Lindson discuss the new evidence in e-cigarette research and interview Professor Reto Auer, primary care physician and clinical researcher from the Institute of Primary Health Care (BIHAM), University of Bern. Reto Auer is Head of the Substance Use Unit, where he leads a variety of research projects, including a large randomized controlled trial designed to test the efficacy, safety and toxicology of nicotine e-cigarettes. Jamie Hartmann-Boyce interviews Reto Auer about his new study published in the New England Journal of Medicine ‘Electronic nicotine delivery systems for smoking cessation'. This trial randomized 1246 participants: 622 to free e-cigarettes and e-liquids, standard-of-care smoking-cessation counselling, and optional (not free) nicotine-replacement therapy; and 624 participants to a control group, which received standard counselling and a voucher, which they could use for any purpose, including nicotine-replacement therapy. This study was funded by the Swiss National Science Foundation and others and registered as ESTxENDS NCT03589989. The percentage of participants with validated continuous abstinence from tobacco smoking was 28.9% in the intervention group and 16.3% in the control group (relative risk, 1.77; 95% confidence interval, 1.43 to 2.20). The study concluded that adding e-cigarettes to standard smoking-cessation counselling resulted in greater abstinence from tobacco use among smokers than smoking-cessation counselling alone. DOI: 10.1056/NEJMoa2308815 This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. Our literature searches carried out on 1st February found the following 1 new study by Lin 2024 (Lin, H-X, Liu Z, Hajek P, Zhang W-T, Wu Y, Zhu B-C, Liu H-H, Xiang Q, Zhang Y, Li S-B, Pesola F, Wang Y-Y, Efficacy of Electronic Cigarettes vs Varenicline and Nicotine Chewing Gum as an Aid to Stop Smoking: A Randomized Clinical Trial, JAMA internal medicine / 2024;(101589534).) 3 new ongoing studies: NCT06169813, E-cigarette Harm Reduction Among PLWHA in South Africa. ISRCTN14068059, E-cigarettes for smoking cessation and reduction in people with a mental illness. Hameed A, Malik D, Clinical study protocol on electronic cigarettes and nicotine pouches for smoking cessation in Pakistan: a randomized controlled trial, Trials / 2024;25(1):9 3 papers linked to studies included in the review: Scheibein F, McGirr K, Morrison A, Roche W, Wells JSG, Correction to: an exploratory non-randomized study of a 3-month electronic nicotine delivery system (ENDS) intervention with people accessing a homeless supported temporary accommodation service (STA) in Ireland, Harm reduction journal 2021;18(1):113 Pesola F, Smith KM, Phillips-Waller A, Przulj D, Griffiths C, Walton R, McRobbie H, Coleman T, Lewis S, Whitemore R, Clark M, Ussher M, Sinclair L, Seager E, Cooper S, Bauld L, Naughton F, Sasieni P, Manyonda I, Hajek P, Safety of e-cigarettes and nicotine patches as stop-smoking aids in pregnancy: Secondary analysis of the Pregnancy Trial of E-cigarettes and Patches (PREP) randomized controlled trial, Addiction (Abingdon, England) / 2024 Trigg J, Rich J, Williams E, Gartner CE, Guillaumier A, Bonevski B, Perspectives on limiting tobacco access and supporting access to nicotine vaping products among clients of residential drug and alcohol treatment services in Australia, Tobacco control 2023 For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 Associate Professor Jamie Hartmann-Boyce and Dr Nicola Lindson discuss the new evidence in e-cigarette research and interview Professor Reto Auer, primary care physician and clinical researcher from the Institute of Primary Health Care (BIHAM), University of Bern. Reto Auer is Head of the Substance Use Unit, where he leads a variety of research projects, including a large randomized controlled trial designed to test the efficacy, safety and toxicology of nicotine e-cigarettes. Jamie Hartmann-Boyce interviews Reto Auer about his new study published in the New England Journal of Medicine ‘Electronic nicotine delivery systems for smoking cessation'. This trial randomized 1246 participants: 622 to free e-cigarettes and e-liquids, standard-of-care smoking-cessation counselling, and optional (not free) nicotine-replacement therapy; and 624 participants to a control group, which received standard counselling and a voucher, which they could use for any purpose, including nicotine-replacement therapy. This study was funded by the Swiss National Science Foundation and others and registered as ESTxENDS NCT03589989. The percentage of participants with validated continuous abstinence from tobacco smoking was 28.9% in the intervention group and 16.3% in the control group (relative risk, 1.77; 95% confidence interval, 1.43 to 2.20). The study concluded that adding e-cigarettes to standard smoking-cessation counselling resulted in greater abstinence from tobacco use among smokers than smoking-cessation counselling alone. DOI: 10.1056/NEJMoa2308815 This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. Our literature searches carried out on 1st February found the following 1 new study by Lin 2024 (Lin, H-X, Liu Z, Hajek P, Zhang W-T, Wu Y, Zhu B-C, Liu H-H, Xiang Q, Zhang Y, Li S-B, Pesola F, Wang Y-Y, Efficacy of Electronic Cigarettes vs Varenicline and Nicotine Chewing Gum as an Aid to Stop Smoking: A Randomized Clinical Trial, JAMA internal medicine / 2024;(101589534).) 3 new ongoing studies: NCT06169813, E-cigarette Harm Reduction Among PLWHA in South Africa. ISRCTN14068059, E-cigarettes for smoking cessation and reduction in people with a mental illness. Hameed A, Malik D, Clinical study protocol on electronic cigarettes and nicotine pouches for smoking cessation in Pakistan: a randomized controlled trial, Trials / 2024;25(1):9 3 papers linked to studies included in the review: Scheibein F, McGirr K, Morrison A, Roche W, Wells JSG, Correction to: an exploratory non-randomized study of a 3-month electronic nicotine delivery system (ENDS) intervention with people accessing a homeless supported temporary accommodation service (STA) in Ireland, Harm reduction journal 2021;18(1):113 Pesola F, Smith KM, Phillips-Waller A, Przulj D, Griffiths C, Walton R, McRobbie H, Coleman T, Lewis S, Whitemore R, Clark M, Ussher M, Sinclair L, Seager E, Cooper S, Bauld L, Naughton F, Sasieni P, Manyonda I, Hajek P, Safety of e-cigarettes and nicotine patches as stop-smoking aids in pregnancy: Secondary analysis of the Pregnancy Trial of E-cigarettes and Patches (PREP) randomized controlled trial, Addiction (Abingdon, England) / 2024 Trigg J, Rich J, Williams E, Gartner CE, Guillaumier A, Bonevski B, Perspectives on limiting tobacco access and supporting access to nicotine vaping products among clients of residential drug and alcohol treatment services in Australia, Tobacco control 2023 For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review updated in January 2024 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub8/full This podcast is supported by Cancer Research UK. This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research interview Cara Murphy, Brown University, USA. Associate Professor Jamie Hartmann-Boyce and Dr Nicola Lindson discuss the new evidence in e-cigarette research and interview Assistant Professor Cara Murphy, clinical psychologist at Brown University. Cara Murphy works at the Center for Alcohol and Addiction in the School of Public Health and the Center for Addiction and Disease Risk Exacerbation. Jamie Hartmann-Boyce interviews Cara Murphy about her new trial, Trial for Harm Reduction With Incentives & Vaping E-cigarettes (THRIVE) and funded by the National Institute of General Medical Sciences. This trial will assess the effect of e-cigarettes and incentives on combustible cigarette smoking in individuals with overweight/obesity who smoke cigarettes. A randomized group of participants will given e-cigarettes for 6 weeks. carbon monoxide will be monitored and participants will either receive fixed incentives for sample completion or receive varying incentives contingent on their carbon monoxide levels. Researchers will compare groups to understand the effect of each condition on smoking-related behaviour. Cara outlines how individuals with overweight/obesity who smoke cigarettes have greatly increased risks of metabolic, cardiac, and pulmonary diseases due to the synergistic effects of tobacco and obesity. Cara also discusses issues faced by people who smoke and are overweight. Switching to e-cigarettes may decrease the risk of negative health outcomes and be a promising approach. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. Our literature searches carried out on 1st December and 1st January found the following . 1 new study by Xu et el 2023 (Xu Y, Goldenson NI, Prakash S Augustson EM, Shiffman S, Randomized trial assessing the effect of the JUUL system on switching away from cigarettes and smoking reduction among U.S. adults who smoke cigarettes. Experimental and clinical psychopharmacology / 2023;(9419066)). 2 new ongoing studies: NCT06111053, Trial for Harm Reduction With Incentives & Vaping E-cigarettes (https://clinicaltrials.gov/study/NCT06111053) and NCT06118502, A Clinical Trial of Adaptive Treatment for Early Smoking Cessation Relapse (ADAPT) (https://clinicaltrials.gov/study/NCT06118502). 1 study by Pope et al 2023 linked to Notley 2023 (Pope I, Notley C, Boyle A, Results of the cessation of smoking trial in the emergency department (COSTED), Emergency Medicine Journal / 2023;40(12):873-874). For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review updated in November 2022 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub7/full This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research interview Eve Taylor, King's College London. Associate Professor Jamie Hartmann-Boyce and Dr Nicola Lindson discuss the new evidence in e-cigarette research and interview Eve Taylor who is working on a PhD in the Nicotine Research Group at King's College London. Eve also works as a research assistant on projects including the International Tobacco Control Project and the Public Health England e-cigarette evidence reviews. Jamie Hartmann-Boyce interviews Eve Taylor at the E-Cigarette Summit, 16th November at the Royal College of Physicians, London. Eve discusses packaging regulations and the role that cigarette packaging and e-cigarette packaging have on the appeal to young people and adults. She draws on findings from the International Tobacco Control Policy Evaluation Project and Action on Smoking and Health (ASH) survey data. The survey data from ASH shows that young people are less interested in trying e-cigarettes in standardised packaging and colours compared to branded packaging. However, changing the packaging does not affect adults, including adults that use combustible cigarettes. Eve discusses the role of flavour names and brand names. The interview highlights that the consequences of any changes in policy need to be thought through and any changes in regulations need to be clear and easily enforceable. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. Our literature searches carried out November 1st 2023 identified: four new ongoing studies (ISRCTN82413824, NCT06063421, NCT06077240, NCT06088862); one linked paper by Prell et al (10.1136/bmjopen-2022-071099) and two reports to be classified. For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review updated in November 2022 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub7/full This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss cigarette packaging, flavours and brand names with Eve Taylor, King's College London. Associate Professor Jamie Hartmann-Boyce and Dr Nicola Lindson discuss the new evidence in e-cigarette research and interview Eve Taylor who is working on a PhD in the Nicotine Research Group at King's College London. Eve also works as a research assistant on projects including the International Tobacco Control Project and the Public Health England e-cigarette evidence reviews. Jamie Hartmann-Boyce interviews Eve Taylor at the E-Cigarette Summit, 16th November at the Royal College of Physicians, London. Eve discusses packaging regulations and the role that cigarette packaging and e-cigarette packaging have on the appeal to young people and adults. She draws on findings from the International Tobacco Control Policy Evaluation Project and Action on Smoking and Health (ASH) survey data. The survey data from ASH shows that young people are less interested in trying e-cigarettes in standardised packaging and colours compared to branded packaging. However, changing the packaging does not affect adults, including adults that use combustible cigarettes. Eve discusses the role of flavour names and brand names. The interview highlights that the consequences of any changes in policy need to be thought through and any changes in regulations need to be clear and easily enforceable. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. Our literature searches carried out November 1st 2023 identified: four new ongoing studies (ISRCTN82413824, NCT06063421, NCT06077240, NCT06088862); one linked paper by Prell et al (10.1136/bmjopen-2022-071099) and two reports to be classified. For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review updated in November 2022 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub7/full This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research interview Eve Taylor, King's College London. Associate Professor Jamie Hartmann-Boyce and Dr Nicola Lindson discuss the new evidence in e-cigarette research and interview Eve Taylor who is working on a PhD in the Nicotine Research Group at King's College London. Eve also works as a research assistant on projects including the International Tobacco Control Project and the Public Health England e-cigarette evidence reviews. Jamie Hartmann-Boyce interviews Eve Taylor at the E-Cigarette Summit, 16th November at the Royal College of Physicians, London. Eve discusses packaging regulations and the role that cigarette packaging and e-cigarette packaging have on the appeal to young people and adults. She draws on findings from the International Tobacco Control Policy Evaluation Project and Action on Smoking and Health (ASH) survey data. The survey data from ASH shows that young people are less interested in trying e-cigarettes in standardised packaging and colours compared to branded packaging. However, changing the packaging does not affect adults, including adults that use combustible cigarettes. Eve discusses the role of flavour names and brand names. The interview highlights that the consequences of any changes in policy need to be thought through and any changes in regulations need to be clear and easily enforceable. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. Our literature searches carried out November 1st 2023 identified: four new ongoing studies (ISRCTN82413824, NCT06063421, NCT06077240, NCT06088862); one linked paper by Prell et al (10.1136/bmjopen-2022-071099) and two reports to be classified. For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review updated in November 2022 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub7/full This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research interview Associate Professor Natalie Walker from the University of Auckland, New Zealand. Associate Professor Jamie Hartmann-Boyce and Dr Nicola Lindson discuss the new evidence in e-cigarette research and interview Associate Professor Natalie Walker, Faculty of Medical and Health Sciences, Social and Community Health, University of Auckland, New Zealand. Natalie Walker discusses her study exploring the effectiveness of nicotine salt vapes, cytisine, and a combination of these products, for smoking cessation in New Zealand. This is a three-arm, pragmatic, community-based randomised controlled trial. They have just finished recruiting 800 participants and the results of this study will be published 2024. This study is funded by the Health Research Council of New Zealand. We also hear about the stop smoking policies taking place in New Zealand and about current levels of smoking and e-cigarette use there. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. Our literature searches carried out October 1st 2023 identified two papers linked to studies previously identified. The study discussed in the podcast, Walker 2023, Effectiveness of nicotine salt vapes, cytisine, and a combination of these products, for smoking cessation in New Zealand: protocol for a three-arm, pragmatic, community-based randomised controlled trial (10.1186/s12889-023-16665-w) linked to ongoing study NCT05311085. The second linked study is Carpenter 2023 (https://doi.org/10.1016/j.eclinm.2023.102142), see also May 2023 podcast. For more information on the full Cochrane review updated in November 2022 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub7/full Or our webpage: https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and Ailsa Butler interviews Andrea Leinberger-Jabari from the Public Health Research Center at New York University, Abu Dhabi, United Arab Emirates. Associate Professor Jamie Hartmann-Boyce and Dr Nicola Lindson discuss the new evidence in e-cigarette research. Ailsa Butler interviews Andrea Leinberger-Jabari, Assistant Director for tobacco research at the Public Health Research Center at New York University, Abu Dhabi, United Arab Emirates. Andrea Leinberger-Jabari talks to Ailsa Butler at the Society for Nicotine and Tobacco Research- E annual conference held in London where Andrea was presenting a poster of her work. Andrea describes her study of e-cigarettes and heated tobacco products in people in the United Arab Emirates (UAE). This is part of a larger cohort study at the Public Health Research Center called the UAE Healthy Futures study. Data is collected from Emirati adults residing in the UAE on tobacco use behaviors and, since becoming legal in 2019, on e-cigarettes and heated tobacco. The overall smoking rate is around 30% and men tend to smoke more than women. Of those who smoke combustible tobacco, over half smoke more than one type of combustible tobacco including cigarettes, shisha, pipe tobacco and Doha tobacco. Most e-cigarette users are people who already smoke combustible tobacco, are male, younger and college educated. The views on the perceived harm of e-cigarettes are mixed; people were unsure if they were more or less harmful than combustible tobacco. The top reasons for using e-cigarettes among people who use combustible tobacco, are that they might help them quit, that they are more acceptable than combustible cigarettes and they can be used in places where combustible cigarettes are banned. People not using combustible cigarettes use e-cigarettes out of curiosity and because they taste good. The EC market is new in the UAE and is growing rapidly, so continued monitoring of e-cigarettes and heated tobacco use in this emerging market will inform further policy and regulation The results of this study presented as a poster will be published soon. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. Our literature searches carried out August 1st and September 1st 2023 identified one new (Rose 2023 https://dx.doi.org/10.1007/s00213-023-06401-y), two linked (Przulj 2023 https://doi.org/10.3310/AGTH6901) (Kanobe 2023, https://dx.doi.org/10.3390/toxics11070564) and one new ongoing study (https://clinicaltrials.gov/ct2/show/NCT05960305). For more information on the full Cochrane review updated in November 2022 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub7/full Or our webpage: https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Assistant Professor Joanna Streck from Massachusetts General Hospital, USA. Associate Professor Jamie Hartmann-Boyce and Dr Nicola Lindson discuss the new evidence in e-cigarette research and interview Assistant Professor of Psychology, Joanna Streck, from the Department of Psychiatry at Massachusetts General Hospital in the US. Joanna Streck talks about her new study looking at the feasibility, acceptability and preliminary effects of switching from combustible cigarettes to e-cigarettes in individuals in treatment for opioid use disorder. The trial name is: Switching Individuals in Treatment for Opioid Use Disorder Who Smoke Cigarettes to the Standardized Research E-Cigarette (SREC). The goal of this study is to conduct a pilot randomized waitlist-controlled trial to assess the feasibility, acceptability, and preliminary effects of substituting the National Institute for Drug Abuse standardized research e-cigarette (SREC) for combustible cigarettes in people who use medications for opioid disorder and combustible cigarettes who are not ready to quit smoking. A waitlist controlled randomised controlled trial of 40 participants will investigate the impact of SREC provision on: tobacco use behaviour; biomarkers (e.g., carbon monoxide); cigarette dependence and withdrawal; and short-term health effects and tolerability. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. For more information on the study see: https://clinicaltrials.gov/show/NCT05881304 Our literature search carried out July 1st 2023 identified two new ongoing studies. The study above and NCT0588794, Impact of E-cigarette Nicotine Concentration on Compensation. For more information on the full Cochrane review updated in November 2022 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub7/full Or our webpage: https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Associate Sarah Pratt, Department of Psychiatry, Geisel School of Medicine, Dartmouth University, New Hampshire, USA. Associate Professor Jamie Hartmann-Boyce and Dr Nicola Lindson discuss the new evidence in e-cigarette research and interview Associate Professor Sarah Pratt from Dartmouth University. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. Sarah Pratt discusses her research and her study of e-cigarette provision to people with serious mental illness to support them transitioning away from combustible tobacco. This research is funded by the US National Institute on Drug Abuse. An abstract of this work was presented at the Society for Research into Nicotine and Tobacco, SRNT, meeting in 2023 and published in Nicotine & Tobacco Research last year. People with serious mental illness (SMI) have great difficulty quitting and sustaining abstinence, warranting novel harm reduction strategies, including switching to potentially reduced-harm nicotine products, such as e-cigarettes. Sarah Pratt and her team conducted the first-ever trial of e-cigarette provision with instructions on their safe use versus usual care in 240 chronic smokers with SMI. They tested whether substitution of e-cigarettes could reduce harm as measured by the cigarette metabolite and carcinogen NNAL (the nitrosamine (4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol). The e-cigarette group had significantly lower NNAL at 4 weeks but the group difference was attenuated at 8 weeks. This study demonstrated rapid short-term harm reduction among chronic smokers with SMI assigned to receive e-cigarettes. The attenuation of this effect at 8 weeks suggests that smokers with SMI require more than e-cigarette provision alone to maintain reduced smoking. Sarah and her team conclude that development of a behavioural intervention in addition to e-cigarette provision seems warranted to prevent morbidity and early mortality in this high-risk group of smokers. For more information on the study see: Pratt SI, Ferron JC, Brunette MF, Santos M, Sargent J, Xie H. E-Cigarette Provision to Promote Switching in Cigarette Smokers with Serious Mental Illness-A Randomized Trial. Nicotine Tob Res. 2022 Aug 6;24(9):1405-1412. doi: 10.1093/ntr/ntac082. PMID: 35363874; PMCID: PMC9356685. SRNT 2023, abstract PPS22-5, RCT assessing the effect of e-cigarettes versus usual smoking on NNAL among chronic smokers with serious mental illness.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Professor Matthew Carpenter, Medical University of South Carolina, USA. Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Professor Matthew Carpenter. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. In the May 2023 episode Jamie Hartmann-Boyce talks with Professor Matthew Carpenter from the Medical University of South Carolina (MUSC) in Charleston SC, and co-leader of the Cancer Control Program within MUSC Hollings Cancer Center. Matthew Carpenter's primary research interests relate to tobacco use: craving and nicotine dependence, clinical trials for smoking cessation, and public health policy for effective tobacco control. Jamie interviews Matthew at the US E-cigarette Summit in Washington DC and asks about his Naturalistic E-Cig Trial (CONNECT) funded by National Cancer Institute. In this randomised controlled trial 638 participants who use combustible cigarettes are allocated to either: a control arm where they can continue using combustible cigarettes; or given an NJOY electronic cigarette to sample and can continue smoking their usual cigarettes as much or as little as they would like. The study gathered information on e-cigarette product use, purchasing of e-cigarettes and cessation of use of combustible cigarettes at 6 months. The study found an increase in quit attempts and an increase in smoking cessation of combustible cigarettes in the intervention arm. We will include the results in our Cochrane review when these become available. For more information on the study see: https://clinicaltrials.gov/ct2/show/NCT03453385 Our literature searches carried out between February 2023 and May 2023 found 2 new studies (Kanobe 2022, DOI 10.1038/s41598-022-25054-z & NCT03453385) 5 linked studies and 1 new ongoing study (NCT05703672) which may be relevant to our review when it is completed. For more information on the full Cochrane review updated in November 2022 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub7/full Or our webpage: https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 This podcast is supported by Cancer Research UK.

In this episode Associate Professor Jamie Hartmann-Boyce and Dr Nicola Lindson discuss the emerging evidence in e-cigarette research and interview Professor Jonathan, Penn State College of Medicine. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. In the January 2023 episode Jamie Hartmann-Boyce interviews Professor Jonathan Foulds from the Center for Research on Tobacco & Health, Penn State College of Medicine. Professor Foulds discusses his randomised controlled study of the effect of electronic nicotine delivery systems (ENDS) or e-cigarettes on combustible cigarette abstinence in people who use combustible cigarettes with no plans to quit. Their study had 520 adult participants who were interested in reducing but had no plans to quit using combustible cigarettes. The participants received brief advice and were randomized to one of four 24-week conditions, receiving either an eGo-style ENDS paired with 0, 8, or 36 mg/ml nicotine liquid (double-blind) or a cigarette-shaped tube, as a cigarette substitute (CS). Self-reported daily cigarette consumption and exhaled carbon monoxide (CO) were measured at all study visits. At 24 weeks, significantly more participants in the 36 mg/ml condition (10.8%) than in the 0 mg/ml condition (0.8%) and the CS condition (3.1%) were abstinent. The abstinence rate in the 8 mg/ml condition was 4.6%. Their randomized trial found study that few participants quit combustible cigarettes in the short term. However, if participants continued to use an ENDS with cigarette-like nicotine delivery, a greater proportion of participants completely switched to ENDS, as compared with placebo or a cigarette substitute. Jamie and Nicola also bring us up to date with the literature search conducted in January 2023. The searches identified 1 new ongoing study NCT05639790. We will include the studies we have found in future updates of the Cochrane review. For more information on the study see the full paper DOI: 10.1093/ntr/ntab247 For more information on the full Cochrane review updated in November 2022 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub7/full Or our webpage: https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 This podcast is supported by Cancer Research UK.

In this episode Associate Professor Jamie Hartmann-Boyce and Dr Nicola Lindson discuss the emerging evidence in e-cigarette research and summarise the findings of the newly published update to the Cochrane review of e-cigarettes for smoking cessation. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. In the November 2022 episode Jamie Hartmann-Boyce and Nicola Lindson bring us up to date with the latest findings from our Cochrane review of e-cigarettes for smoking cessation. The latest Cochrane Review finds high certainty evidence that nicotine e-cigarettes are more effective than traditional nicotine-replacement therapy (NRT) in helping people quit smoking. Jamie and Nicola summarise their research led by the University of Oxford, and funded by Cancer Research UK, which has found the strongest evidence yet that e-cigarettes, also known as 'vapes', help people to quit smoking better than traditional nicotine replacement therapies, such as patches and chewing gums. The new evidence published in the Cochrane Library finds high certainty evidence that people are more likely to stop smoking for at least six months using nicotine e-cigarettes, or 'vapes', than using nicotine replacement therapies, such as patches and gums. Evidence also suggested that nicotine e-cigarettes led to higher quit rates than e-cigarettes without nicotine, or no stop smoking intervention, but less data contributed to these analyses. The updated Cochrane review includes 78 studies in over 22,000 participants - an addition of 22 studies since the last update in 2021. Smoking is a significant global health problem. According to the World Health Organisation (WHO), in 2020, 22.3% of the global population used tobacco, despite it killing up to half of its users. Stopping smoking reduces the risk of lung cancer, heart attacks and many other diseases. Though most people who smoke want to quit, many find it difficult to do so permanently. Nicotine patches and gum are safe, effective and widely used methods to help individuals quit. E-cigarettes heat liquids with nicotine and flavourings, allowing users to 'vape' nicotine instead of smoking. Data from the review showed that if six in 100 people quit by using nicotine replacement therapy, eight to twelve would quit by using electronic cigarettes containing nicotine. This means an additional two to six people in 100 could potentially quit smoking with nicotine containing electronic cigarettes. For more information on the full Cochrane review updated in September 2021 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub7/full or our webpage https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 This podcast is supported by Cancer Research UK.

In this episode Associate Professor Jamie Hartmann-Boyce and Dr Nicola Lindson discuss the emerging evidence in e-cigarette research and summarise the findings of the newly published update to the Cochrane review of e-cigarettes for smoking cessation. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. In the November 2022 episode Jamie Hartmann-Boyce and Nicola Lindson bring us up to date with the latest findings from our Cochrane review of e-cigarettes for smoking cessation. The latest Cochrane Review finds high certainty evidence that nicotine e-cigarettes are more effective than traditional nicotine-replacement therapy (NRT) in helping people quit smoking. Jamie and Nicola summarise their research led by the University of Oxford, and funded by Cancer Research UK, which has found the strongest evidence yet that e-cigarettes, also known as 'vapes', help people to quit smoking better than traditional nicotine replacement therapies, such as patches and chewing gums. The new evidence published in the Cochrane Library finds high certainty evidence that people are more likely to stop smoking for at least six months using nicotine e-cigarettes, or 'vapes', than using nicotine replacement therapies, such as patches and gums. Evidence also suggested that nicotine e-cigarettes led to higher quit rates than e-cigarettes without nicotine, or no stop smoking intervention, but less data contributed to these analyses. The updated Cochrane review includes 78 studies in over 22,000 participants - an addition of 22 studies since the last update in 2021. Smoking is a significant global health problem. According to the World Health Organisation (WHO), in 2020, 22.3% of the global population used tobacco, despite it killing up to half of its users. Stopping smoking reduces the risk of lung cancer, heart attacks and many other diseases. Though most people who smoke want to quit, many find it difficult to do so permanently. Nicotine patches and gum are safe, effective and widely used methods to help individuals quit. E-cigarettes heat liquids with nicotine and flavourings, allowing users to 'vape' nicotine instead of smoking. Data from the review showed that if six in 100 people quit by using nicotine replacement therapy, eight to twelve would quit by using electronic cigarettes containing nicotine. This means an additional two to six people in 100 could potentially quit smoking with nicotine containing electronic cigarettes. For more information on the full Cochrane review updated in September 2021 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub7/full or our webpage https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 This podcast is supported by Cancer Research UK.

Associate Professor Jamie Hartmann-Boyce and Dr Nicola Lindson discuss the emerging evidence in e-cigarette research and interview Dr Leonie Brose, King's College London. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. In the October episode Jamie Hartmann-Boyce interviews Dr Leonie Brose, Reader in Addiction Education and Nicotine Research at King's College London. Leonie Brose talks about the findings of a randomised controlled trial carried out with Dr Markos Klonizakis and the team at Sheffield Hallam University on the medium- and longer-term cardiovascular effects of e-cigarettes in adults making a stop-smoking attempt. The study compared cardiovascular effects in smokers attempting to quit smoking using e-cigarettes with or without nicotine or prescription nicotine replacement therapy (NRT). The study concluded that smokers attempting to quit experienced positive cardiovascular impact after both a 3- and 6-month period. None of the groups (i.e., nicotine-containing and nicotine-free e-cigarettes or NRT) offered superior cardiovascular benefits to the others. https://doi.org/10.1186/s12916-022-02451-9 Dr Brose also discusses the findings of the report by the Office for Health Improvements and Disparities (OHID) on Nicotine vaping in England: 2022 evidence update summary. The report aims to summarise the evidence on vaping products and to inform policies and regulations. It is a large body of work with 16 chapters covering policy and regulation, vaping and youth and presents the evidence on biomarkers of exposure and biomarkers associated with cancer, respiratory, cardiovascular and other health outcomes. The report also has chapters on fires, poisons and explosions linked to ECs, heated tobacco products and perceptions of harm. The headline from the report was that vaping poses only a small fraction of the risk of smoking combustible cigarettes. Jamie and Nicola also bring us up to date with the literature search conducted in October 2022. The October search identified 1 new study (https://doi.org/10.1186/s12916-022-02451-9), 3 ongoing studies and 1 record linked to a previously identified study. We will include the studies we have found in future updates of the Cochrane review. OHID Report: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1107701/Nicotine-vaping-in-England-2022-report.pdf https://www.gov.uk/government/publications/nicotine-vaping-in-england-2022-evidence-update/nicotine-vaping-in-england-2022-evidence-update-summary For more information on the full Cochrane review updated in September 2021 see: https://doi.org/10.1002/14651858.CD010216.pub6 or our webpage https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 This podcast is supported by Cancer Research UK.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Harry Tattan-Birch. In the September episode Jamie Hartmann-Boyce interviews Harry Tattan-Birch from the Department of Behavioural Science and Health, University College London. Harry Tattan-Birch talks about their team's recent randomised controlled trial examining whether, in adults receiving behavioural support, offering e-cigarettes together with varenicline helps more people stop smoking cigarettes than varenicline alone. Tentative evidence suggests that offering e-cigarettes alongside varenicline to people receiving behavioural support may be more effective for smoking cessation than varenicline alone. https://doi.org/10.1093/ntr/ntac149 Harry Tattan-Birch also discusses his research into heated tobacco products. This work was funded by the Oxford University Public Policy Challenge Fund and Cancer Research UK. Jamie and Nicola also bring us up to date with the literature search conducted between July and September 1st 2022. The July, August and September searches found 6 new studies. We will include the studies we have found in future updates of the Cochrane review. For more information on the full Cochrane review updated in September 2021 see: https://doi.org/10.1002/14651858.CD010216.pub6 or our webpage: https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Dr Francesca Pesola. In the June episode Jamie Hartmann-Boyce talks with Francesca Pesola from the Wolfson Institute of Population Health Queen Mary University of London. Dr Francesca Pesola talks to Associate Professor Jamie Hartmann-Boyce about the results from the trial comparing e-cigarettes to nicotine patches for smoking cessation in pregnant women. Professor Tim Coleman discussed this study in the May 2021 podcast and the results have now been published in Nature Medicine, Hajek et al 2022 (DOI: 10.1038/s41591-022-01808-0). Dr Pesola outlines the need to identify smoking cessation aids to help women quit during pregnancy. Dr Pesola discusses the results of their randomised control trial of 1,140 participants comparing refillable e-cigarettes with nicotine patches. In this trial pregnant women who smoke were randomized to e-cigarettes or nicotine patches. Dr Pesola reports that the unadjusted analysis of the primary outcome of validated quit rates at the end of pregnancy were not found to be significantly different between the e-cigarette and nicotine patch arms. However, Dr Pesola explains that some people in the study used non-allocated products, for example people in the nicotine patch group were also found to be using e-cigarettes. This meant that if they then quit there was uncertainty as to whether the quitting behaviour was due to the nicotine patches or to the e-cigarettes. The study team had anticipated this behaviour and pre-specified that they would exclude people who were abstinent and who had used non-allocated products. Dr Pesola reports that after doing this e-cigarettes were found to be more effective than patches. The safety profile was similar for both study products, however, low birthweight (

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Dr Francesca Pesola. In the June episode Jamie Hartmann-Boyce talks with Francesca Pesola from the Wolfson Institute of Population Health Queen Mary University of London Dr Francesca Pesola talks to Associate Professor Jamie Hartmann-Boyce about the results from the trial of e-cigarettes compared to nicotine patches for smoking cessation in pregnant women. Professor Tim Coleman discussed this study in our May 2021 podcast and the results have now been published in Nature Medicine, Hajek et al 2022 (DOI: 10.1038/s41591-022-01808-0). Dr Pesola outlines the need to identify smoking cessation aids to help women quit during pregnancy. Dr Pesola discusses the results of their randomised control trial of 1,140 participants comparing refillable e-cigarettes with nicotine patches in which pregnant women who smoke were randomized to e-cigarettes or nicotine patches. Dr Pesola reports that the unadjusted analysis of the primary outcome of validated quit rates at the end of pregnancy were not found to be significantly different between the e-cigarette and nicotine patch arms. However, Dr Pesola explains that some people in the study used non-allocated products, for example people in the nicotine patch group were also found to be using e-cigarettes. This meant that if they then quit you were not able to be sure whether the quitting behaviour was due to the nicotine patch or to the e-cigarette. The study team had anticipated this behaviour and pre-specified that they would exclude people who were abstinent and who had used non-allocated products. Dr Pesola reports that after doing this e-cigarettes were found to be more effective than patches. The safety profile was similar for both study products, however, low birthweight (

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Neal Benowitz. In this episode Associate Professor Jamie Hartmann-Boyce and Dr Nicola Lindson discuss the emerging evidence in e-cigarette research and interview Professor Neal Benowitz. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. Long description In the May episode Jamie Hartmann-Boyce talks with Neal Benowitz, Emeritus Professor at the University of California San Francisco, Professor Benowitz practices medicine, cardiology and clinical pharmacology and has a particular interest in tobacco as a major risk factor for cardiovascular disease. Professor Neal Benowitz talks to Associate Professor Jamie Hartmann-Boyce about the toxicological data from studies of e-cigarettes. He stresses the importance of comparing e-cigarette use to combustible cigarette use, as the exposure to biomarkers that we can measure is much lower in people who vape than in people who use combustible cigarettes. He discusses the issue that many e-cigarette users have been long-term combustible cigarette users so it is difficult to separate out the effects of each. He stresses the need for longitudinal studies among people who have only used e-cigarettes and have not used combustible cigarettes. He also discusses the need to look at the different types of e-cigarettes, there are many different products and toxicity will vary between the different e-cigarette devices. Jamie and Nicola discuss recent work comparing biomarkers of harm. Exclusive e-cigarette use was associated with lower levels of biomarkers of harm than exclusive use of combustible tobacco, or use of a combination of combustible tobacco. This work was funded by the Oxford University Public Policy Challenge Fund and Cancer Research UK. Jamie and Nicola also bring us up to date with the literature search conducted on May 1st 2022. The May search found 2 new studies, 3 new ongoing studies and 2 records linked to previously identified studies. We will include the studies we have found in future updates of the Cochrane review. For more information on the full Cochrane review updated in September 2021 see: https://doi.org/10.1002/14651858.CD010216.pub6 or our webpage https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Neal Benowitz. In this episode Associate Professor Jamie Hartmann-Boyce and Dr Nicola Lindson discuss the emerging evidence in e-cigarette research and interview Professor Neal Benowitz. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. Long description In the May episode Jamie Hartmann-Boyce talks with Neal Benowitz, Emeritus Professor at the University of California San Francisco, Professor Benowitz practices medicine, cardiology and clinical pharmacology and has a particular interest in tobacco as a major risk factor for cardiovascular disease. Professor Neal Benowitz talks to Associate Professor Jamie Hartmann-Boyce about the toxicological data from studies of e-cigarettes. He stresses the importance of comparing e-cigarette use to combustible cigarette use, as the exposure to biomarkers that we can measure is much lower in people who vape than in people who use combustible cigarettes. Professor Benowitz points out that many e-cigarette users have been long-term combustible cigarette users so it is difficult to separate out the effects of each. He highlights the need for longitudinal studies among people who have only used e-cigarettes and have not used combustible cigarettes. Professor Benowitz also discusses the need to look at the different types of e-cigarettes, there are many different products and toxicity will vary between the different e-cigarette devices. Jamie and Nicola discuss recent work comparing biomarkers of harm. Exclusive e-cigarette use was associated with lower levels of biomarkers of harm than exclusive use of combustible tobacco, or use of a combination of combustible tobacco. This work was funded by the Oxford University Public Policy Challenge Fund and Cancer Research UK. Jamie and Nicola also bring us up to date with the literature search conducted on May 1st 2022. The May search found 2 new studies, 3 new ongoing studies and 2 records linked to previously identified studies. We will include the studies we have found in future updates of the Cochrane review. For more information on the full Cochrane review updated in September 2021 see: https://doi.org/10.1002/14651858.CD010216.pub6 or our webpage https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Alex Liber. In the April episode Jamie Hartmann-Boyce talks with Assistant Professor Alex Liber, Department of Oncology at Georgetown University's School of Medicine, Washington DC, USA. Alex Liber discusses his work at the intersection between markets, public policy, and public health. Alex Liber discusses global tobacco control policy research and tax and price policy. He talks about why different countries react differently to policies and to why tobacco control is seen as the battle of politics, business, and health. He discusses the need for comparative regulatory language. Alex discusses the different e-cigarette policies adopted around the world. Turning to flavours Alex tells us about his work with his colleagues at Georgetown and the University of Michigan on the potential effects of a ban on the sale of menthol cigarettes in the United States. He expanded this work to on menthol cigarettes to look at European sales data and to the effect of the European Union's menthol cigarette ban of menthol cigarette sales in Poland. He reports that although the share of menthol cigarettes sales was 30% in Poland, cigarette sales overall did not drop. He explains that tobacco companies were able to convert their menthol cigarette smokers into standard flavour cigarette smokers, via rebranding cigarettes and flavouring cards. Alex is interested in documenting industry responses. Alex also discusses work looking at e-cigarette flavour bans and temporary bans in the US. Jamie and Nicola also bring us up to date with the literature search conducted on April 1st 2022. The April search found 4 new ongoing studies. We will include the studies we have found in future updates of the Cochrane review. For more information on the full Cochrane review updated in September 2021 see: https://doi.org/10.1002/14651858.CD010216.pub6 or our webpage

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Dr Ailsa Butler. Assistant Professor Jamie Hartmann-Boyce and Dr Nicola Lindson talk with Dr Ailsa Butler from the Centre for Evidence Based Medicine, University of Oxford and co-author of the Cochrane review of e-cigarettes for smoking cessation. They discuss the findings of their recent work on the longer term use of e-cigarettes when provided as a tool to stop smoking. In the studies eligible for the review, just over half of people given nicotine e-cigarettes at study start were found to be still using e-cigarettes at six or more months follow up. Of successful quitters, 70% were found to still be using e-cigarettes at six months or more. The longer-term use of nicotine e-cigarettes may reflect their success as a quit smoking aid by preventing relapse to smoking. A key question about long-term e-cigarette use in people who have quit combustible cigarettes is whether it prevents or facilitates relapse or has no effect on relapse. This work was funded by Cancer Research UK and Oxford University's Public Policy Challenge Grant. Jamie and Nicola also bring us up to date with the literature search conducted on March 1st 2022. The search found 1 record linked to a study already identified as ongoing. We will include the studies we have found in future updates of the Cochrane review.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Professor Billie Bonevski. In this episode Assistant Professor Jamie Hartmann-Boyce and Dr Nicola Lindson discuss the emerging evidence in e-cigarette research and interview Professor Billie Bonevski. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. In the February episode Dr Nicola Lindson talks with Professor Billie Bonevski, Professor of Public Health, Flinders University, South Australia. Professor Billie Bonevski discusses her Team's QuiENDS pilot trial of electronic cigarettes for smoking cessation among people in alcohol and other drug treatment. Professor Bonevski discusses e-cigarettes as a harm reduction tool and as part of a solution to high levels of smoking and very low or non-existent rates of quitting seen in this group. The study looks at people using e-cigarettes to quit abruptly or to reducing more gradually. Going forward work has started on the follow up Harmony Trial. Jamie and Nicola also bring us up to date with the literature search conducted on February 1st 2022. The February search found 2 ongoing studies and 2 records linked to a studies already included the review. We will include the studies we have found in future updates of the Cochrane review.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Professor Billie Bonevski. In this episode Assistant Professor Jamie Hartmann-Boyce and Dr Nicola Lindson discuss the emerging evidence in e-cigarette research and interview Professor Billie Bonevski. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. In the February episode Dr Nicola Lindson talks with Professor Billie Bonevski, Professor of Public Health, Flinders University, South Australia. Professor Billie Bonevski discusses her Team's QuiENDS pilot trial of electronic cigarettes for smoking cessation among people in alcohol and other drug treatment. Professor Bonevski discusses e-cigarettes as a harm reduction tool and as part of a solution to high levels of smoking and very low or non-existent rates of quitting seen in this group. The study looks at people using e-cigarettes to quit abruptly or to reducing more gradually. Going forward work has started on the follow up Harmony Trial. Jamie and Nicola also bring us up to date with the literature search conducted on February 1st 2022. The February search found 2 ongoing studies and 2 records linked to a studies already included the review. We will include the studies we have found in future updates of the Cochrane review.

In this episode Assistant Professor Jamie Hartmann-Boyce and Dr Nicola Lindson discuss the emerging evidence in e-cigarette research and interview Dr Sharon Cox. This podcast is a companion to the Electronic Cigarettes Cochrane Living Systematic Review. The podcasts shares the evidence from the Cochrane monthly searches. In the January episode Jamie Hartmann-Boyce talks with Dr Sharon Cox, Senior Research Fellow at the Department for Behavioural science and Health from University College London's Tobacco and Alcohol Research Group. Study trial registry number: ISRCTN18566874 Dr Sharon Cox discusses her team's multi centred cluster randomised controlled trial based in homeless centres in the UK. In this study people experiencing homelessness who smoke are being offered e-cigarettes or usual care. This trial is funded by NIHR. Centre staff will provide EC arm participants with a tank‐style refillable EC starter kit, a choice of nicotine strength e‐liquids and flavours and an EC fact‐sheet. E‐liquids will be supplied for four weeks at weekly intervals by centre staff. Participants will be given time to try different flavours and nicotine strengths at baseline and be permitted to switch between flavours in accordance with documented vaping practices. Jamie and Nicola also bring us up to date with the literature search conducted on January 1st 2022. The January search found 4 ongoing studies and 1 record linked to a study already in the review. We will include the studies we have found in future updates of the Cochrane review. For more information on the full Cochrane review updated in September 2021 see: https://doi.org/10.1002/14651858.CD010216.pub6 or our webpage: https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Professor Anne Joseph. In the November 2021 episode Jamie Hartmann-Boyce talks with Professor Anne Joseph from the Department of Medicine, University of Minnesota Medical School, Minneapolis, about her study carried out with a team at the University of Minnesota and study's first author Kolawole Okuyemi, Department of Family and Preventive Medicine, University of Utah, Salt Lake City. DOI:  10.1093/ntr/ntab212 Professor Anne Joseph discusses her team's recent study that compares the effects of e-cigarettes with and without nicotine on patterns of combustible cigarette use and biomarkers of exposure to tobacco toxicants among African American smokers. Professor Joseph outlines that there are many reasons to look at the question of e-cigarette use with and without nicotine among African American smokers. African Americans are disproportionately impacted by tobacco-related diseases, for example lung cancer. This is in spite of different patterns of smoking by African Americans, such as smoking fewer average cigarettes per day but having more difficulty stopping smoking. In real world settings people change their behaviour without support of researchers and clinicians, Professor Joseph's study aimed to replicate this by providing little behavioural support. Participants were given a choice of menthol and non-menthol flavoured e-cigarette cartridges and were asked to use e-cigarettes ad libitum for 6 weeks. The majority of participants (88.6%) selected menthol e-cigarettes. Follow-up assessments were conducted at 2, 6, and 12 weeks post randomisation. Contrary to their hypotheses, they found that nicotine e-cigarettes did not significantly reduce the use of combustible cigarettes compared to non-nicotine e-cigarettes in this cohort of African American smokers. Their findings suggested that e-cigarettes were modestly associated with decreased use of combustible cigarettes among non-treatment seeking smokers, regardless of nicotine content, but without a reduction in tobacco toxicants. Professor Joseph considered that although e-cigarettes have potential to reduce harm if substituted for combusted cigarettes (or if they promoted cessation) because of lower levels of tobacco toxicants, their study suggested that ad libitum use of e-cigarettes among African American smokers, with or without nicotine, resulted in modest smoking reduction but did not change toxicant exposure in a cohort where smoking cessation or reduction was not the goal. The authors considered that their data suggested that testing future harm reduction interventions using e-cigarettes should include more specific behavioural change coaching, including substituting for or completely stopping combusted cigarettes. For more information on the full Cochrane review updated in September 2021 see: https://doi.org/10.1002/14651858.CD010216.pub6 or our webpage. Jamie and Nicola bring us up to date with the literature search conducted on November 1st. The November search found one new study described in the podcast. The DOI for the new included study (Okuyemi 2021) is 10.1093/ntr/ntab212 . We will include the studies we have found in future updates of the Cochrane review.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Nicholas DeVito. In this episode Jamie Hartmann-Boyce and Nicola Lindson discuss the emerging evidence in e-cigarette research and interview Nicholas DeVito. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. In the October 2021 episode Jamie Hartmann-Boyce talks with Nick DeVito from the Evidence Based DataLab at the University of Oxford. They discuss his recent research which looks at e-cigarette manufacturers' compliance with clinical trial reporting expectations focussing on trials by Juul Labs and how they report their data. Nick's study was published in BMJ Tobacco Control (http://dx.doi.org/10.1136/tobaccocontrol-2020-056221). The discussion covered the importance of whether, where and how research findings are reported or published including publication bias and reporting bias, the selective reporting of outcomes. This interview covers the crucial role of trial registration for research transparency. Nick describes the FDA amendment act, in which studies are registered within 21 days with pre-registered outcomes and a primary completion date and that the results are to be put onto clinicaltrials.gov within a year. Clinicians, public health professionals, and the public cannot make informed choices about the benefits or hazards of e-cigarettes if the results of clinical trials are not completely and transparently reported. This interview highlights that transparency is key and the importance of all evidence being made available. For more information on the September Cochrane review see: https://doi.org/10.1002/14651858.CD010216.pub6 or our webpage. Jamie and Nicola also bring us up to date with the literature search conducted on October 1st. The October search found one new included study two reports linked to studies already in the review, and one new ongoing (NCT04854616). The DOI for the new included study (Morris 2021) is https://doi.org/10.1007/s11739-021-02813-w. We will include the studies we've found in future updates of the Cochrane review.

Jamie Hartmann-Boyce and Nicola Lindson discuss the September 2021 update of their Cochrane living review of electronic cigarettes for smoking cessation, their response to a paper by Pisinger et al 2020 and emerging evidence in e-cigarette research. In this episode Jamie Hartmann-Boyce and Nicola Lindson discuss the emerging evidence in e-cigarette research and two recent publications by the group: the September 2021 update to the Cochrane living review of electronic cigarettes for smoking cessation; and a response to a paper by Pisinger et al 2020. This podcast is a companion to our Cochrane living systematic Review and shares the evidence from monthly searches and review findings. Jamie and Nicola discuss the team's response to a paper by Pisinger and Vestbo 2020, and underline that the aim of the Cochrane process is to always focus on the evidence (DOI: 10.1183/13993003.02117-2021 or link). They then outline the findings of the September update to the review which includes five new studies that have been added since the April 2021 version and includes search findings up to 1st May 2021. Overall the review includes 61 studies representing 16,759 participants. The main findings remain the same and some new comparisons have been included. There is still moderate certainty that nicotine containing e-cigarettes help more people to quit at 6 months or longer compared to e-cigarettes without nicotine or than NRT (nicotine replacement therapy). Uncertainty also still exists around nicotine containing e-cigarettes compared to no intervention (e.g. continued smoking). This reflects that the quality of the evidence is considered very low according to Cochrane standards. There is moderate certainty evidence that neither nicotine e-cigarettes nor non-nicotine e-cigarettes result in higher numbers of adverse or serious adverse effects. Turning to new comparisons this update includes a study of a pod device (Russell et al), the findings were consistent with the other included studies that showed that more people quit at 6 months or longer using EC than with NRT. This update also includes a study comparing nicotine salt to free-base nicotine e-cigarettes; no clear differences were found between the two. We also included studies that provided 'dual users' (people who already use EC and tobacco cigarettes) with advice on how to use their EC to quit smoking; in one study there was no usable data in a second larger study (Martinez) there was a marginally better quit rate, however there was no clear evidence of benefit. In response to feedback, for the first time in this update, data is included on the proportion of participants still using e-cigarettes or quitting aids) at six months or longer. Data from two studies comparing nicotine EC with NRT were notably different, with one finding no difference in the proportion of participants still using study product at longest follow-up, and the other finding significantly higher levels of EC use than NRT. There was no evidence for a difference in the proportion of people still using EC at longest follow-up in two studies comparing nicotine EC with non-nicotine EC. For all other studies the majority of participants that had been given nicotine EC at the start of the study were still using EC at 6 months or longer. Jamie and Nicola discuss the different ways that this result could be interpreted. It will be important to collect more information on this outcome. For more information on the September Cochrane review see: https://doi.org/10.1002/14651858.CD010216.pub6 or our webpage. Jamie and Nicola also bring us up to date with the literature search conducted on August 1st and September 1st. The August search found one linked study by Rubenstein et al 2021 (doi: 10.1016/j.addbeh.2021.107037) and two new ongoing studies (El-Khoury et al 2021 (doi: 10.1136/bmjopen-2021-048859); and NCT04708106 2021). No new studies were found in the September 1st search. We will include the studies we've found in future updates of the Cochrane review.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research. Dr Katie Myers Smith discusses findings from her recent study. Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and Dr Katie Myers Smith responds to questions on her recent research. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. In the July episode Dr Katie Myers Smith from Queen Mary University of London talks about her team's recent study looking at e-cigarettes versus nicotine replacement therapy (NRT) as a harm reduction intervention for people who smoke and who find quitting difficult. Their randomised controlled study compared e-cigarettes with NRT in 135 people who smoked and who were previously unable to stop smoking with conventional treatments. Dr Myers Smith's study found that in people who smoked and were unable to quit using conventional methods, e-cigarettes were more effective than NRT in facilitating validated long-term smoking reduction and smoking cessation, when limited other support was provided. We will include the results in our Cochrane review. For more information on the study see Myers Smith et al 2021, Addiction, June 2021, DOI: 10.1111/add.15628 . Our July 2021 literature search identified two new included studies (Myers Smith et al 2021, DOI: 10.1111/add.15628 ; Kimber et al 2021 DOI: 10.1016/j.addbeh.2021.106909 ) and two reports linked to studies already in the review (Leavens et al 2021, DOI: 10.1111/add.15597 linked to Pulvers 2020; Jones et al 2021, DOI: 10.1097/ADM.0000000000000881 linked to Klonizakis 2017).

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Professor Thomas Brandon Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Professor Thomas Brandon. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. In the June episode Jamie Hartmann-Boyce talks with Professor Thomas Brandon from the University of South Florida and the Moffitt Cancer Center on his team's new study published in Lancet Public Health. This study is a randomised control trial and investigates the effect of tailored advice to dual users of combustible and electronic cigarettes on how to use their electronic cigarette to quit combustible cigarettes. This targeted self-help intervention with high potential for dissemination could be efficacious in promoting smoking cessation among dual users of combustible cigarettes and e-cigarettes. We will include the results in our Cochrane review. For more information on the study see: Martinez 2021 (https://www.thelancet.com/pdfs/journals/lanpub/PIIS2468-2667(20)30307-8.pdf). Our June 1st literature search found one new protocol by Elling et al 2021 (doi: 10.2196/27088) and two linked studies (NCT01188239 linked to Caponnetto 2013a and a dissertation by Guttentag linked to Tseng 2016 (doi: 10.1093/ntr/ntw017).

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Professor Tim Coleman. Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Professor Tim Coleman. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. In the May episode Jamie Hartmann-Boyce talks with Professor Tim Coleman from the University of Nottingham's Faculty of Medicine and Health Sciences. Professor and GP Tim Coleman discusses a study he is carrying out with colleagues from Queen Mary University of London which looks at helping pregnant women who smoke tobacco cigarettes quit smoking. This trial of 1140 pregnant women compares usual care of behavioural support plus nicotine patches to behavioural support plus e-cigarettes in women willing to receive help to stop smoking. This multi-centre randomised control trial is taking place in the UK and we will include the results in our Cochrane review when these become available. For more information on the study see: https://fundingawards.nihr.ac.uk/award/15/57/85 Our May literature search found four new ongoing studies which may be relevant to our review when they are completed.

Jamie Hartmann-Boyce and Nicola Lindson discuss the April 2021 update to their Cochrane living review of electronic cigarettes for smoking cessation and respond to questions from listeners. Jamie Hartmann-Boyce and Nicola Lindson discuss the April 2021 update to the Cochrane living review of electronic cigarettes for smoking cessation. This podcast is a companion to this Cochrane Review and shares the evidence from monthly searches and review findings. In this episode Jamie Hartmann-Boyce and Nicola Lindson discuss the latest update to the review and respond to questions covering subjects, such as risk of bias, design of randomised control trials (RCTs), second hand vapour and sustainable cessation, put to them by listeners. This update includes six new studies that have been added since the 2020 version of the review and we are pleased to see the first inclusion of an RCT studying e-cigarette pod devices. There is still moderate certainty that nicotine containing e-cigarettes help more people to quit at 6 months or longer compared to e-cigarettes without nicotine or than NRT (nicotine replacement therapy). Uncertainty still exists around nicotine containing e-cigarettes compared to no intervention (eg continued smoking). This reflects that the quality of the evidence is considered very low according to Cochrane standards. In this update the low certainty evidence for no difference in adverse and serious adverse effects between nicotine e-cigarettes and non-nicotine e-cigarettes has been upgraded to moderate certainty evidence. Jamie and Nicola also bring us up to date with the literature search conducted on April 1st, which found one linked and two new ongoing studies. doi: 10.3390/ijerph18020430 ; ANZCTR - Registration ; https://doi.org/10.1093/ehjci/ehaa946.2359

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Professor Caitlin Notley. Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Professor Caitlin Notley. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. In the March episode Jamie Hartmann-Boyce interviews Professor Caitlin Notley from the Addiction Research Group at the University of East Anglia. The interview covers her qualitative research that centres on electronic cigarettes as a harm reduction tool, smoking cessation and relapse prevention in vulnerable populations. Professor Notley also discusses relapse prevention in pregnant and post-partum women and the role of social identity. As well as our usual searches, in March we searched conference abstracts from the annual meeting of the Society for Research on Nicotine and Tobacco (SRNT). We identified four new included studies, five new ongoing studies and five papers linked to studies already included in the review. The four new studies identified are summarised in the ‘in a nutshell' section of the podcast. They are all reported as conference abstracts; three of which were identified from the SRNT 2021 abstract book (SYM2A, SYM2B, PH‐353; https://www.srnt.org/page/2021_Meeting). The fourth was found in a systematic review identified through our search and is available here: http://dx.doi.org/10.1016/j.drugalcdep.2015.07.1091.

Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Dr Rachna Begh. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. In this episode Jamie Hartmann-Boyce and Nicola Lindson interview Dr Rachna Begh about the findings from her ongoing UK Management of Smoking in Primary Care, MaSC, study. This randomised controlled study explores the feasibility, acceptability effectiveness of general practitioner and nurse promotion of e-cigarettes versus standard care for smoking reduction and abstinence in people who smoke and who have smoking-related chronic diseases who are unwilling to stop smoking.