Podcasts about health nih

Dr. Mike Hart interviews board-certified urologist Dr. Alex Tatum about peptide access, compounding, and men's health. Tatum argues many peptides are naturally occurring and lacked FDA commercialization incentives, says the FDA's 2023 move banning 19 compounds from Category 1 was contested due to no produced adverse-safety evidence, and describes the patient impact and advocacy around a July PCAC meeting. He explains most peptide APIs and many compounded GLP-1 ingredients come from China, while pharma-grade GLP-1s have more U.S. production. The discussion covers retatrutide's potential biologic classification (40–amino acid rule) and pricing implications, MOTS-c as an adjunct for low energy on GLP-1s, skepticism about cardarine, growth hormone secretagogues and cancer fears, TRT dosing frequency, sleep apnea screening, HCG's roles, and penis enhancement via traction for length and hyaluronic acid filler for girth, emphasizing expectations and mental health. Dr. Alex Tatem is a board-certified urologist focused on men's health, hormone optimization, male fertility, and sexual wellness. In this episode, he joins Dr. Mike Hart to discuss the changing landscape of peptide therapy, including FDA restrictions, compounding pharmacies, drug supply chains, and the growing debate around access to treatments such as BPC-157, MOTS-c, and retatrutide. He also breaks down practical considerations for men using testosterone replacement therapy, including HCG, fertility preservation, dosing frequency, estrogen-related side effects, and sleep apnea risk. Drawing from his experience treating a wide range of patients, he shares a harm-reduction approach to performance medicine and explains what men should understand before considering growth hormone peptides, GLP-1 medications, or penile enhancement procedures. Dr. Alex Tatem Website https://dralextatem.com/ Dr. Alex Tatem Instagram https://www.instagram.com/dralextatem/ Huberman Lab — Peptides: The Science, Uses & Safety | Dr. Abud Bakri https://www.hubermanlab.com/episode/peptides-the-science-uses-and-safety-abud-bakri FDA Pharmacy Compounding Advisory Committee Meeting — July 23–24, 2026 https://www.fda.gov/advisory-committees/advisory-committee-calendar/july-23-24-2026-meeting-pharmacy-compounding-advisory-committee-07232026 FDA Bulk Drug Substances Under Section 503A https://www.fda.gov/drugs/human-drug-compounding/bulk-drug-substances-used-compounding-under-section-503a-fdc-act FDA Compounding Safety Risks https://www.fda.gov/drugs/human-drug-compounding/certain-bulk-drug-substances-use-compounding-may-present-significant-safety-risks Semaglutide / Ozempic https://medlineplus.gov/druginfo/meds/a618008.html Tirzepatide / Mounjaro https://medlineplus.gov/druginfo/meds/a622044.html Retatrutide Clinical Trial https://clinicaltrials.gov/study/NCT05929066 Testosterone Cypionate https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=testosterone%20cypionate Human Chorionic Gonadotropin / HCG https://pubmed.ncbi.nlm.nih.gov/?term=human+chorionic+gonadotropin BPC-157 https://pubmed.ncbi.nlm.nih.gov/?term=BPC-157 KPV Peptide https://pubmed.ncbi.nlm.nih.gov/?term=KPV+peptide TB-500 / Thymosin Beta-4 https://pubmed.ncbi.nlm.nih.gov/?term=thymosin+beta-4 MOTS-c https://pubmed.ncbi.nlm.nih.gov/?term=MOTS-c CJC-1295 https://pubmed.ncbi.nlm.nih.gov/?term=CJC-1295 Ibutamoren / MK-677 https://pubmed.ncbi.nlm.nih.gov/?term=ibutamoren+MK-677 Cardarine / GW501516 https://pubmed.ncbi.nlm.nih.gov/?term=GW501516+cardarine PhalloFILL at Urology of Indiana https://menshealthin.com/services/phallofill/ Hyaluronic Acid Penile Girth Enhancement Overview https://auanews.net/issues/articles/2024/august-extra-2024/office-and-surgical-technologies-the-evolving-landscape-of-penile-girth-enhancement   Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:33 Are Peptides Threatening Pharma 01:17 Patent Law and FDA Categories 02:19 The 2023 Peptide Ban Fallout 03:59 Safety or Money Debate 06:09 China Supply Chain Exposed 11:33 RFK Jr Peptide Messaging 16:01 Retatrutide Biologic Fight 20:51 What Biologic Status Costs 25:27 MOTS-c as GLP-1 Booster 28:43 Growth Hormone Cancer Myth 32:18 Sleep Effects and Bryan Johnson 35:04 Microplastics and Saunas 36:48 Cardarine Cancer Risk 40:07 TRT and HCG Basics 45:08 HCG Dosing Nuance 49:06 Daily TRT Microdosing 52:03 Sleep Apnea on TRT 56:34 Penis Enhancement Options 01:02:54 Realistic Expectations 01:04:46 Wrap Up and Where to Follow   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

As we continue our summer programming around a specific theme in the headlines, this week we're focusing on the subject of truth in media with previous Bulletin guests Chris Stirewalt, Francis Haugen, Renee DiResta, and Francis Collins. This episode of The Bulletin weaves together three distinct conversations exploring the death of local reporting, the rise of algorithmic echo chambers, and a practical blueprint for how Christians can navigate the news with wisdom and discernment. GO DEEPER WITH THE BULLETIN: Join the conversation at our Substack.  Find us on YouTube.  Rate and review the show in your podcast app of choice.  ABOUT THE GUESTS: Chris Stirewalt is a senior fellow at the American Enterprise Institute where he focuses on American politics, voting trends, public opinion, and the media. He is concurrently a contributing editor and weekly columnist for The Dispatch, and the host of The Hill Sunday with Chris Stirewalt on NewsNation. A well-known political commentator, Mr. Stirewalt is the author of Broken News: Why the Media Rage Machine Divides America and How to Fight Back. Francis Collins, MD, PhD, served as director of the National Institutes of Health (NIH) under presidents Obama, Trump, and Biden. Prior to that, he led the Human Genome Project at NIH, coordinating a consortium of laboratories to produce the first ever complete sequence of human DNA in 2003. Collins's research has led to landmark discoveries of disease genes and helped pioneer a multitude of therapies for many diseases. Renee DiResta  is a professor, writer and former research manager at Stanford Internet Observatory. DiResta has written about pseudoscience, conspiracy theories, terrorism, and state-sponsored information warfare. Frances Haugen is an American data scientist and product manager who became a prominent whistleblower in 2021 after disclosing thousands of internal Facebook documents to the SEC and The Wall Street Journal. She highlighted that Facebook prioritized profit over safety, fostering hate and misinformation. ABOUT THE BULLETIN:  The Bulletin is a twice-weekly news analysis podcast from Christianity Today, with editor-at-large Russell Moore. Each episode offers commentary on current events and headlining news with a roundtable of premier guests, and shares a Christian perspective on issues that are shaping our world   The Bulletin listeners get 25% off CT. Go to https://orderct.com/THEBULLETIN to learn more.    “The Bulletin” is a production of Christianity Today Host: Leslie Thompson Associate Producers: Alexa Burke and Crystal Dady   Editing and Mix: Kevin Morris Graphic Design: Rick Szuecs Music: Dan Phelps  Executive Producer: Erik Petrik  Senior Producer: Matt Stevens Learn more about your ad choices. Visit podcastchoices.com/adchoices

//The Wire//1800Z June 3, 2026// //ROUTINE// //BLUF: TARGETING EFFORTS INCREASE THROUGHOUT MIDDLE EAST AS U.S. TARGETS QESHM ISLAND, AND IRANIAN MISSILES AND DRONES STRIKE BAHRAIN AND KUWAIT. HOSTAGE SITUATION CONCLUDES AT BANK IN CALIFORNIA. TWO NIH EMPLOYEES ARRESTED AFTER ATTEMPTING TO SMUGGLE MONKEYPOX INTO THE USA.// -----BEGIN TEARLINE------International Events-Middle East: Overnight the war continued to expand with multiple strikes reported throughout the region. Following the now-daily American airstrikes on Qeshm Island, the Iranians retaliated by launching multiple ballistic missiles targeting locations in Kuwait and Bahrain. CENTCOM claimed that none of the missiles impacted their targets, however Kuwait International Airport was directly hit by at least one large munition (possibly a Shahed-type drone). The main terminal was heavily damaged, and a total of 63x individuals were wounded during this attack. Additionally, locals in residential areas to the north claim that Camp Buehring was also hit by a ballistic missile, though satellite imagery is still pending to confirm this.Separately, multiple munition impacts were reported in Bahrain though the details of these strikes remain less certain than in Kuwait. Some reports claim that Sakhir Air Base was hit, however this is not confirmed at this time.-HomeFront-California: Yesterday a hostage situation was reported in Bakersfield after a man entered Chase Bank on 17th Street with what he claimed was an explosive device. The man claimed to have wired an explosive vest with a deadman switch, and took a total of 5x hostages inside the bank. The individual has been identified as Anthony Scott Searle-Sharris, who conducted this incident for personal reasons, claiming that he was wrongfully convicted of previous crimes (crimes against children). The hostage situation continued throughout the night, before the suspect was neutralized this morning by an FBI sniper team. All hostages have been recovered in good health.Michigan: Two researchers for the National Institute of Health (NIH) were arrested in Detroit, after attempting to smuggle monkeypox into the United States. Vincent Munster (from the Netherlands) and Claude Kwe (from Cameroon) were arrested after a search of their belongings at customs revealed chilled storage for 113 vials which contained Monkeypox along with other pathogens.-----END TEARLINE-----Analyst Comments: As a reminder, the information lockdown is palpable throughout the Middle East, so details are hard to verify. What is absolutely undeniable at this point, is that authorities throughout the region, to include CENTCOM, are posting very misleading "fact checks" which are carefully worded by attorneys to leave out critical details. In some cases, outright lies are being told to conceal the success of Iranian strikes. This has been the case since the start of the war, and it's extremely common for various entities to lie during a time of war, which is sometimes necessary to ensure mission success. If CENTCOM wants to conceal the success of strikes for operational security purposes that's their business, but we can't pretend that this is not happening.As luck would have it, the Sentinel 2 open-source imagery satellite passed over Camp Ali Al Salem a few hours after the missile attacks. Comparing the imagery taken today, with yesterday's pass, a discernable impact can be noted at one of the aircraft hangers on the airfield. As always, the Iranians already know about the success of their own strikes as the Iranians secretly purchased the Chinese TEE-01B satellite, which grants them their own imagery for Battle Damage Assessments (in addition to the wealth of intelligence support being provided by Russia and China). As a result, concealing the details of American bases getting hit is hiding the truth from exactly one audience...the American taxpayer.Around the region, the locals within GCC states are first hand observers to the strikes, even though most Arab nations are arresting their own citizens for posting videos of failed interceptions in order to keep the illusion going that air defenses are working. One such individual was arrested last night in Kuwait after posting a viral video while driving on the highway. While it is speculative, it's possible that the reason this individual was arrested is because it was easy to identify him due to the motor vehicle accident that also occurred at the same time and thus made the video go viral, but also because his video appears to show failed interceptions...several of the Patriot missiles fired at the incoming Iranian missiles appear to have missed and exhibited the telltale self-destruct phase of their flight path. It's a classic Middle Eastern shakey-cam situation, but the Kuwaitis are very motivated to conceal the true effects of Iranian targeting efforts and the impact craters observed throughout the country this morning add credence to the failed interceptions.This challenging information environment would be very wise to remember as the "good news" posts of impending peace saturate social media and mainstream media constantly at this point. The truth of the situation on the ground indicates that strikes on Iranian targets (specifically at Bandar Abbas and Qeshm Island) are now daily occurrences, and the slow ramp-up to the collapse of the ceasefire has already been underway for several days.Analyst: S2A1 Research: https://publish.obsidian.md/s2underground Disclaimer: No LLMs were used in the writing of this report. //END REPORT//

The host explains how he raised his estimated VO2 max in 2026 in his 40s, emphasizing that the biggest driver was structured hard training with progressive overload, not "hacks" like peptides, supplements, sauna, red light, or ketones. After years of mostly zone 2 cardio (under ~124 bpm) plus weekly MMA, he shifted to one zone 2 session, one Norwegian 4x4 VO2 max workout, and one MMA session weekly. He defines VO2 max and details the 4x4 protocol (4 minutes hard/3 minutes easy for 4 rounds plus brief warmup/cooldown), using a COROS heart rate monitor to track significant zone 5 time. Starting at 8.0 mph, he increased treadmill speed by 0.1 mph weekly to 9.3 mph, discussing deload weeks, fatigue limits, body weight changes, footwear, sauna frequency, and mixed views on supplements like beta-alanine, beetroot, and ketones.   Norwegian 4x4 Protocol https://www.myworkout.com/en/4x4-intervals VO2 Max / Zone 2 Cardio https://health.clevelandclinic.org/zone-2-cardio Stats Canada VO2 Max Percentile Table https://www150.statcan.gc.ca/n1/pub/82-003-x/2019010/article/00002/tbl/tbl02-eng.htm Oura Ring https://ouraring.com/ COROS Heart Rate Monitor https://coros.com/heart-rate-monitor Freak Athlete Nordic Hyper / Hyper Pro https://freakathlete.co/products/hyper-pro HOKA Clifton 10 https://www.hoka.com/en/ph/clifton-10-run-smooth/ Nike Zoom Fly https://www.nike.com/ph/w/nike-zoom-fly-running-shoes-37v7jz7oc5azy7ok Post-Exercise Sauna Bathing Study https://pubmed.ncbi.nlm.nih.gov/16877041/ Urolithin A https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2788244 Beetroot / Dietary Nitrate https://www.ausport.gov.au/ais/nutrition/supplements/group_a/performance-supplements2/beetroot-juicenitrate Ketone-IQ https://ketone.com/ Beta-Hydroxybutyrate / BHB Ketones https://www.ncbi.nlm.nih.gov/books/NBK493179/ L-Citrulline https://ods.od.nih.gov/factsheets/ExerciseAndAthleticPerformance-HealthProfessional/ Creatine https://ods.od.nih.gov/factsheets/ExerciseAndAthleticPerformance-HealthProfessional/ Beta-Alanine https://examine.com/supplements/beta-alanine/ MOTS-c https://pmc.ncbi.nlm.nih.gov/articles/PMC9905433/ Cardarine / GW501516 https://www.wada-ama.org/en/news/wada-issues-alert-gw501516 Brady Holmer https://www.bradyholmer.com/ Hart2Heart Episode with Brady Holmer https://open.spotify.com/episode/0DxQVb0Mkah57ZgHbWmWUy   Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:33 VO2 Max Story Setup 01:27 Baseline Training Split 02:58 What VO2 Max Means 05:10 Why Add Structure 06:01 Norwegian 4x4 Explained 06:49 Starting Speeds Recovery 08:07 Zone 5 Targets 10:55 Tracking Heart Rate 12:23 Estimating VO2 Max 14:37 Zone 2 And MMA Role 17:20 Bodyweight And Running 19:46 Shoes Sauna Supplements 24:44 Progressive Overload Plan 29:34 Deloads Plateaus Mindset 31:29 Final Takeaways Encouragement   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

Spine Health Researcher, Clinician, and Professor, Dr. Christine Goertz shares her life's work in her new book Take Your Back Back. RESEARCH & HEALTH POLICY CAREER I'm Christine Goertz, D.C., Ph.D. I have spent 35 years working with multi-disciplinary teams to conduct research studies and implement best practices designed to optimize care for patients with low back pain. CURRENT ROLE I am a Professor in Musculoskeletal Research at the Duke Clinical Research Institute and Vice Chair for the Implementation of Spine Health Innovation in the Department of Orthopaedic Surgery at Duke University. I am also an Adjunct Professor in the Department of Epidemiology, College of Public Health at the University of Iowa.  WHERE IT ALL BEGAN I received my Doctor of Chiropractic (D.C.) degree from Northwestern Health Sciences University in 1991 and a Ph.D. in Health Services Research, Policy and Administration from the School of Public Health at the University of Minnesota in 1999. ACCOMPLISHMENTS I have extensive experience in the administration of Federal grants, both as a PI and as a program official at the National Institutes of Health (NIH). I have received nearly $45 million in federal funding, as the principal investigator or co-principal investigator, primarily from NIH and the Department of Defense. I have also co-authored more than 135 peer-reviewed scientific papers. MAKING A GLOBAL IMPACT I am honored to have delivered invited lectures, keynote talks, clinical grand rounds, and plenary presentations worldwide. Topics include "Research, Its Not Just for Scientists Anymore," "In Search of the Holy Grail in Low Back Pain Treatment or Anything that Works at All," and " Nonpharmacological Approaches to Pain Management." Venues include the Patient Centered Outcomes Research Institute Annual Meeting, Georgetown University, Duke University School of Medicine, the American Physical Therapy Association's Combined Sections Meeting, the American Chiropractic Association Summit, the World Federation of Chiropractic Research Congress, and the European Chiropractic Union.  Resources: Dr. Goertz's website The Back Pain Chronicles Pain Trainer Take Your Back Back The Cox 8 Table by Haven Medical Find a Back Doctor  

Dr. Ksenia Petrushkina joins Dr. Mike Hart for a deep dive into regenerative medicine, peptides, hormones, IV therapies, and longevity. They discuss what conventional medicine and health influencers often get wrong about prevention-focused care, while exploring topics like NAD+, glutathione, GLP-1s, gut health, skin aging, mitochondrial health, BPC-157, TB-500, IGF-1, and peptide safety. Dr. Ksenia also shares why testing, inflammation, absorption, and overall health matter before using peptides or other optimization treatments. Dr. Ksenia Petrushkina is a regenerative medicine practitioner based in Aventura, Florida, and part owner of Ideal Medical and Wellness. Her work focuses on hormones, peptides, IV therapies, stem cells, and longevity, with a background in biopharmaceutical science and cancer research. She brings a prevention-focused, mechanism-based perspective to patient care, especially around inflammation, gut health, metabolic function, peptide safety, and age-related optimization. Dr. Ksenia Miami Instagram https://www.instagram.com/dr.kseniamiami/](https://www.instagram.com/dr.kseniamiami/) Ideal Medical and Wellness https://idealmedwell.com/](https://idealmedwell.com/) Tadalafil / Cialis https://medlineplus.gov/druginfo/meds/a604008.html](https://medlineplus.gov/druginfo/meds/a604008.html) PT-141 / Bremelanotide [https://medlineplus.gov/druginfo/meds/a619054.html](https://medlineplus.gov/druginfo/meds/a619054.html) GHK-Cu copper peptide https://pmc.ncbi.nlm.nih.gov/articles/PMC6073405/](https://pmc.ncbi.nlm.nih.gov/articles/PMC6073405/) Tretinoin / Retin-A https://medlineplus.gov/druginfo/meds/a682437.html](https://medlineplus.gov/druginfo/meds/a682437.html) NAD+ https://pmc.ncbi.nlm.nih.gov/articles/PMC7963035/](https://pmc.ncbi.nlm.nih.gov/articles/PMC7963035/) Nicotinamide Riboside / NR https://pmc.ncbi.nlm.nih.gov/articles/PMC6611812/](https://pmc.ncbi.nlm.nih.gov/articles/PMC6611812/) Tru Niagen [https://www.truniagen.com/](https://www.truniagen.com/) Glutathione https://pmc.ncbi.nlm.nih.gov/articles/PMC4684116/](https://pmc.ncbi.nlm.nih.gov/articles/PMC4684116/) GLP-1 drugs https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/fdas-concerns-unapproved-glp-1-drugs-used-weight-loss](https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/fdas-concerns-unapproved-glp-1-drugs-used-weight-loss) Tirzepatide https://medlineplus.gov/druginfo/meds/a622044.html](https://medlineplus.gov/druginfo/meds/a622044.html) BPC-157 https://www.usada.org/spirit-of-sport/bpc-157-peptide-prohibited/](https://www.usada.org/spirit-of-sport/bpc-157-peptide-prohibited/) TB-500 / Thymosin beta-4 https://pubmed.ncbi.nlm.nih.gov/22074294/](https://pubmed.ncbi.nlm.nih.gov/22074294/) Melanotan II https://dermnetnz.org/topics/melanotan-ii](https://dermnetnz.org/topics/melanotan-ii) IGF-1 test https://medlineplus.gov/lab-tests/igf-1-insulin-like-growth-factor-1-test/](https://medlineplus.gov/lab-tests/igf-1-insulin-like-growth-factor-1-test/) Tesamorelin https://medlineplus.gov/druginfo/meds/a611035.html](https://medlineplus.gov/druginfo/meds/a611035.html)   Thymosin Alpha-1 https://pmc.ncbi.nlm.nih.gov/articles/PMC7747025/](https://pmc.ncbi.nlm.nih.gov/articles/PMC7747025/) SS-31 / Elamipretide https://pmc.ncbi.nlm.nih.gov/articles/PMC11816484/](https://pmc.ncbi.nlm.nih.gov/articles/PMC11816484/) Urolithin A https://pubmed.ncbi.nlm.nih.gov/35050355/](https://pubmed.ncbi.nlm.nih.gov/35050355/) Coenzyme Q10 / CoQ10 https://www.nccih.nih.gov/health/coenzyme-q10](https://www.nccih.nih.gov/health/coenzyme-q10) Pancreatic enzymes https://medlineplus.gov/druginfo/meds/a604035.html](https://medlineplus.gov/druginfo/meds/a604035.html) Psyllium husk https://medlineplus.gov/druginfo/meds/a601104.html](https://medlineplus.gov/druginfo/meds/a601104.html)   Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:38 Preventive Medicine Debate 03:03 Low Dose Cialis Basics 05:03 Prostate Cancer Link 08:18 ED Alternatives PT-141 11:52 Skin Aging Essentials 12:19 GHK-Cu Dosing Risks 15:59 Copper Uglies Explained 19:47 NAD Boosting Options 24:33 NR Infusions Trend 27:38 Glutathione and Thyroid 31:58 Stopping Levothyroxine 33:34 Glutathione Precursors Limits 34:58 Gut Protocol NAD GLP1 35:59 Tirzepatide Microdosing Guide 38:18 Glutathione Injection Protocol 40:47 BPC 157 Cancer Myth 43:28 BPC TB500 Injury Cycles 45:13 Melanotan II Skin Risks 46:50 IGF1 Aging Tradeoffs 49:16 Safest GH Secretagogue 50:05 Underrated Thymosin Alpha 52:35 Mitochondria Peptides SS31 55:00 MITC and AMPK Hype 56:36 Urolithin A and CoQ10 01:00:36 GLP1 Supplements and Labs 01:02:39 Wrap Up and Where to Find   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

It's In The News, where we bring you the top diabetes stories and headlines happening now. Top stories this week: Dexcom shares details of its next generation CGM, T1D and GLP-1 studies, weight loss management on GLP-1 medications updates, all-in-one CGM and pump, and more! Announcing Community Commericals! Learn how to get your message on the show here. Learn more about studies and research at Thrivable here Please visit our Sponsors & Partners - they help make the show possible! Omnipod - Simplify Life All about Dexcom  All about VIVI Cap to protect your insulin from extreme temperatures The best way to keep up with Stacey and the show is by signing up for our weekly newsletter: Sign up for our newsletter here Here's where to find us: Facebook (Group) Facebook (Page) Instagram Check out Stacey's books! Learn more about everything at our home page www.diabetes-connections.com  Episode transcript: XX Dexcom announces some features of it's next generation CGM – the G8. We've been talking about this with CEO Jake Leach for a while now – it will be a 50% smaller with what they're calling advanced sensing capabilities. According to Leach, G8 will adapt to the physiologic variability of each user. It has additional technology built in, based on a new silicon chip design and algorithm. 15 day wear is now the baseline for all Dexcom sensors moving forward. At launch the G8 will only measure glucose but the plan is for a multi-analyte version to follow. That would measure ketones and potassium. Ketones we know – but potassium is very important for people with kidney and possible for people taking some diabetes meds. It's an interesting space to watch.. btw, analyte is just a medical word for the specific thing you're measuring – the target of the test you're running. we're going to hear that word a lot I think..   Looks like an FDA submission for the G8 next year.. with an outside the US launch the following year. https://www.drugdeliverybusiness.com/dexcom-unveils-next-gen-g8-cgm/ XX Glucotrack has submitted its implantable continuous blood glucose monitor (CBGM) for FDA IDE, that's investigational device exemption and would enable the company to initiate a U.S. clinical study for the fully implantable technology. Rutherford, New Jersey-based Glucotrack's device features no on-body external component. The company aims to offer it for three years of continuous, accurate blood glucose monitoring for a more convenient, less intrusive solution. Unlike traditional CGMs that measure glucose in interstitial fluid, the CBGM measures glucose levels directly from the blood. The implant goes five centimeters within the subclavian vein. Glucotrack's active implantable device has a small battery and some electronics that go just under the skin in the pectoral region. The location of the implant is not in a major vessel, but the implant can measure real-time glucose levels as pulsatile blood flows over the tip of the sensor. https://www.drugdeliverybusiness.com/glucotrack-submits-long-term-implantable-cbgm-fda-ide/ XX PharmaSens today announced the publication of data from the first clinical study evaluating its all-in-one insulin patch pump offering. The all-in-one pump pairs the Niaa Essential insulin patch pump with the SynerG continuous glucose monitor (CGM) sensor developed by Pacific Diabetes Technologies. However, this system would be one device that features both the pump and CGM technology.   PharmaSens and SiBionics also have a collaboration aimed at developing the all-in-one solution. They are jointly developing the next-generation Niia insulin patch pump with a SiBionics CGM. PharmaSens expects a second feasibility study in the second quarter to evaluate the next-generation pump with SiBionics' CGM.   PharmaSens says the clinical feasibility study of Niia demonstrated for the first time ever that the combined offering is, in fact, feasible. It believes its device addresses the need for alternatives to multi-device diabetes management. systems.   Aggregated MARD for the investigational device came in at 11.6%. A MARD target of less than 10% is considered ideal for CGM devices, but PharmaSens said that, in the context of the early feasibility study, the results were encouraging and provide evidence supporting the development of an all-in-one system. https://www.drugdeliverybusiness.com/pharmasens-efs-insulin-patch-pump-cgm/ XX   XX ViCentra launches the newest version of the Kaleido pump system in Europe. This is that small colorful pump, with Diabeloops algorithm and the Dexcom G7. It'll be in Germany and the Netherlands later this summer. https://hellokaleido.com/vicentra-announces-commercial-launch-of-new-smartphone-controlled-kaleido-automated-insulin-delivery-patch-pump-system/--   XX Diabeloop just got CE Mark approval for DBLG2 integrations – it's latest AID platform the company has kicked off the gradual European launch of the technology. It currently offers DBLG2 as a smartphone application on Android, with iOS integration coming soon. As you just heard, it's integrated with kaleido and the company says it plans to make additional configuration for DBLG2 with alternative pumps "available soon." Running on a user's smartphone, DBLG2 works as a self-learning algorithm. It continuously analyzes glucose data, calculates insulin needs in real time and automatically adjusts delivery. https://www.drugdeliverybusiness.com/diabeloop-fda-next-gen-algorithm-g7/   XX Among adults with type 1 diabetes (T1D), the initiation of GLP-1-based therapy was associated with a lower risk for all-cause death, several cardiovascular outcomes, all-cause hospitalisations, and hypoglycaemia, without a higher risk for diabetic ketoacidosis.   METHODOLOGY: Researchers in Greece conducted a retrospective cohort study utilising real-world data from a global health research network to evaluate the association between GLP-1-based therapy and cardiovascular and renal outcomes in adults with T1D. A total of 4088 patients receiving GLP-1-based therapies (median age, 43 years; 34.3% men) were propensity score matched with an equal number of patients not receiving the treatment. The risk for hypoglycaemia was lower with GLP-1-based therapy (hazard ratio, 0.72; P = .021); however, the risk for diabetic ketoacidosis did not differ significantly between the two groups. https://www.medscape.com/viewarticle/glp-1-drugs-tied-cardiovascular-benefits-t1d-2026a1000fbx   XX Eli Lilly and Company (NYSE: LLY) today announced detailed results from two late-phase trials showing that people with obesity maintained their weight loss long term with either Foundayo or lower-dose Zepbound after switching from higher doses of injectable incretin therapy. The findings from SURMOUNT-MAINTAIN and ATTAIN-MAINTAIN, were presented at the 33rd European Congress on Obesity (ECO) and published in The Lancet and Nature Medicine, respectively.   "Weight regain remains one of the biggest challenges in obesity care, and is often the result of treatment interruptions that cause biology to work against patients, undoing the progress they've made," said Louis J. Aronne, M.D., FACP, DABOM, founder and Chair Emeritus of the American Board of Obesity Medicine, former president of The Obesity Society, Fellow of the American College of Physicians, world-renowned obesity specialist and Lilly consultant. "These medicines can be used for long-term maintenance today, and results from SURMOUNT-MAINTAIN and ATTAIN-MAINTAIN provide additional evidence of their potential when switching from higher doses of injectable incretin therapy." https://investor.lilly.com/news-releases/news-release-details/lillys-foundayo-and-lower-dose-zepbound-helped-people-maintain XX Scientists in Sweden have developed a more reliable way to create insulin-producing cells from human stem cells. These lab-grown cells not only respond strongly to glucose but were also able to restore blood sugar control when transplanted into diabetic mice. When transplanted into diabetic mice, the cells gradually restored the animals' ability to regulate blood sugar. Long way to go, as we say with most of these mice studies. https://www.sciencedaily.com/releases/2026/05/260505234620.htm XX Interesting look at how the body controls sugar storage – apparently this finding challenges long-standing biology concepts and could open new directions for disease treatment. Published in Nature, the study describes a potential method for directly reducing glycogen, the stored form of sugar in the body. These scientists discovered that glycogen can be directly regulated by ubiquitin, a protein best known for marking damaged proteins for recycling or removal. The study is the first to show that ubiquitin can regulate glycogen in humans, overturning more than 50 years of scientific understanding. Excess glycogen is also associated with more common health problems, including diabetes, obesity, liver disease, and heart disease.       https://scitechdaily.com/scientists-just-rewrote-biology-hidden-mechanism-could-transform-diabetes-treatment/ XX A new Oklahoma law will give parents the option to have their children screened for Type 1 Diabetes.   The measure passed with overwhelming bipartisan support in the Legislature and takes effect Nov 1. Oklahoma consistently ranks among the states with the highest rates of diabetes and diabetes-related deaths. The law gives parents access to antibody testing that can detect risk years before symptoms develop, helping families take preventive action and avoid emergency room visits. https://journalrecord.com/2026/05/11/oklahoma-law-expands-access-type-1-diabetes-screening/ XX More to come including a new study trying to figure out why some people are more likely to develop diabetes, a look at cannabis and preventing metabolic disorders, and XX   A National Institutes of Health (NIH)-funded study has identified key differences in human pancreatic islet cells that may help explain why some people are more likely to develop diabetes. Researchers found that the mix of hormone-producing cells in the pancreas varies widely from person to person, and that variation plays a central role in how the body regulates blood sugar. The study involved a deep dive into islet cell function that is linked to donor traits associated with observable characteristics, or phenotype, such as sex, race and ethnicity, as well as genetic information, or genotype, including predicted ancestry and genetic risk for both type 1 and type 2 diabetes. The findings highlight that islet cell composition, rather than the physical size and shape of islets, is a key factor in regulating hormone release. The team found that the makeup of pancreatic islets plays a major role in how effectively they release insulin and glucagon — key hormones that regulate blood glucose. Islets with a higher proportion of insulin-producing beta cells showed stronger insulin secretion in response to various stimuli, while higher levels of alpha and delta cells were generally linked to reduced insulin output. In addition, the researchers found that islet hormone secretion is affected by donor traits, such as sex, race and ethnicity and their genetic makeup, including ancestry predicted from genetic testing and genetic risk for type 2 diabetes. Combined, the findings of the study have significant implications for understanding the factors that may predispose people to diabetes. "This study is the tip of the iceberg," said Dr. Evans-Molina. "We hope this dataset becomes useful to the entire diabetes research community and that researchers use it to answer questions about the genotype-phenotype correlation within these data."   https://www.nih.gov/news-events/news-releases/nih-funded-study-maps-human-pancreatic-islet-cells-offering-new-clues-diabetes-risk XX XX XX Research published recently in JAMA Network Open offers illuminating evidence suggesting there is a positive association between GLP-1 agonists—drugs commonly used to treat obesity and diabetes—and better outcomes among breast cancer patients.   "This study suggests that GLP-1 drugs may offer protective benefits potentially improving survival and recurrence risk in some female patients with breast cancer – whether this is related to weight control, improve cardiovascular health or other mechanisms remains to be studied," said study senior author Bernard F. Fuemmeler, Ph.D., MPH, associate director for population sciences and the Gordon D. Ginder, M.D., Chair in Cancer Research at VCU Massey Comprehensive Cancer Center.   Breast cancer patients who are also obese or have type 2 diabetes experience more aggressive cancer growth and worse outcomes. Prior studies have shown that weight loss treatment and surgery following a breast cancer diagnosis are associated with improved heart health and increased survival.   What are GLP-1 drugs? Glucagon-like peptide-1 receptor agonists (GLP-1 RAs). Approved to treat type 2 diabetes in 2005 and weight management in 2021. Impacts on breast cancer survival and recurrence are still unclear. Since 2020, the use of these drugs has increased dramatically, where approximately 12% of Americans have used GLP-1s for weight loss, according to a RAND report.   The research findings Through a retrospective cohort study examining the electronic health records of more than 840,000 breast cancer patients who were diagnosed between 2006 and 2023, the results suggest there is a potential link between GLP-1 RAs and improved outcomes among breast cancer patients who are also obese or have type 2 diabetes.   GLP-1 RA use was associated with an overall lower risk of death from any cause over a 10-year follow-up period among breast cancer patients. Additionally, breast cancer survivors who used GLP1-RAs for diabetes or obesity had a significantly lower risk of their cancer returning over 10 years following their initial treatment.   "Our findings align with emerging preclinical research and contribute to a growing body of literature related to GLP-1 RA use in oncology settings," said study lead author Kristina L. Tatum, PsyD, MS, of the VCU School of Public Health.   What's next? Further studies are needed to understand the biological mechanisms, if any, between GLP-1 RAs and breast cancer outcomes. The research team intends to further evaluate these correlations through randomized clinical trials.   "Our study underscores the potential of GLP-1 RAs as an adjunct strategy for improving cancer-related outcomes among patients with breast cancer, although clinical trials are needed to inform effective therapeutic approaches and clinical decision making," Fuemmeler said. https://www.oncology-central.com/could-glp-1-receptor-agonists-improve-outcomes-for-breast-cancer-patients-with-obesity-or-with-type-2-diabetes/ XX Researchers at UC Riverside gave cannabis to obese mice and found that not only did the rodents lose weight, but when given a concentrated cannabis oil, the mice also saw striking benefits in their metabolic function. DiPatrizio said his team studied the issue to better understand why cannabis users show significant reductions in weight and risk for diabetes compared with nonusers. "We would think that chronic cannabis users would be eating more and weigh more, but it's just the opposite," DiPatrizio said. Scientists are increasingly examining the possibility that cannabis compounds could fight obesity or metabolic disorders like diabetes. Cannabinoids interact with the body's endocannabinoid system, which partially controls nearly every aspect of our physiology, including metabolism and appetite. That creates the possibility that targeting this widespread system could unlock new therapies for these conditions. https://www.sfgate.com/cannabis/article/cannabis-weight-loss-california-study-22255328.php XX A new campaign launched by diaTribe and Genentech aims to empower and educate people about diabetes-related eye disease. Here's what you can do today to protect your eye health. To help address these barriers, diaTribe and Genentech partnered to launch All Eyes on DME, a new campaign that aims to spread awareness and educate people at-risk for or living with diabetes-related eye conditions like DME. Also partnering in the campaign is actor and comedian Damon Wayans, who wanted to share his journey (and, of course, a joke or two) with type 2 diabetes to open up the conversation about what is often a stigmatized or less talked about topic: eye health and diabetes.   One of these important conversations happened recently at the All Eyes on DME launch in New York City, where Wayans joined a panel of experts, advocates, and people living with DME to talk about diabetes-related eye disease and how to help prevent it. https://www.alleyesondme.com/dme-in-the-spotlight.html https://diatribe.org/diabetes-complications/all-eyes-dme-new-campaign-spotlights-eye-health-and-diabetes

The episode explains that inflammation is a necessary survival mechanism, with acute inflammation supporting healing, while chronic inflammation drives chronic disease. It outlines major contributors to chronic inflammation including visceral fat (with fasting insulin as a proxy for insulin resistance), poor sleep and sleep apnea, ultra-processed foods, sedentary behavior, overtraining, chronic psychological stress, poor oral health, gut dysbiosis/barrier issues, smoking, alcohol, pollution, autoimmune disease, and chronic infection. The host reviews biomarkers to discuss with a physician such as high-sensitivity CRP, ESR, ferritin, WBC and neutrophil-to-lymphocyte ratio, fasting insulin, ApoB, omega-3 index/omega-6:omega-3 ratio, and homocysteine. Chronic inflammation is linked to cardiovascular disease, depression/anhedonia, brain fog, autoimmune disease risk, cancer mechanisms, skin aging, erectile dysfunction, and chronic pain. Treatment focuses on lifestyle (notably treating sleep apnea, sleep optimization, fat loss, exercise, oral health, omega-3 intake, sauna, stress regulation, circadian rhythm), selected supplements (vitamin D if deficient, curcumin, boswellia, ginger, garlic, olive oil polyphenols, sulforaphane, magnesium/glycine, taurine, NAC, quercetin, probiotics, creatine), and brief discussion of drugs including GLP-1 agonists, colchicine, NSAIDs, corticosteroids, and biologics.   Chronic inflammation https://www.ncbi.nlm.nih.gov/books/NBK493173/ C-reactive protein test https://medlineplus.gov/lab-tests/c-reactive-protein-crp-test/ ESR blood test https://medlineplus.gov/lab-tests/erythrocyte-sedimentation-rate-esr/ Ferritin blood test https://medlineplus.gov/lab-tests/ferritin-blood-test/ Homocysteine test https://medlineplus.gov/lab-tests/homocysteine-test/ ApoB test https://my.clevelandclinic.org/health/diagnostics/24992-apolipoprotein-b-test Insulin resistance https://www.ncbi.nlm.nih.gov/books/NBK507839/ Obstructive sleep apnea https://medlineplus.gov/ency/article/000811.htm CPAP therapy https://medlineplus.gov/ency/article/001916.htm Sleep hygiene https://www.cdc.gov/sleep/about_sleep/sleep_hygiene.html Physical activity guidelines https://www.cdc.gov/physical-activity-basics/guidelines/adults.html Ultra-processed foods https://pmc.ncbi.nlm.nih.gov/articles/PMC10831891/ Gum disease https://www.cdc.gov/oral-health/about/gum-periodontal-disease.html Gut microbiome https://www.nccih.nih.gov/health/gut-microbiome-what-you-need-to-know Fiber https://www.hsph.harvard.edu/nutritionsource/carbohydrates/fiber/ Autoimmune diseases https://medlineplus.gov/autoimmunediseases.html Inflammation and heart disease https://www.heart.org/en/health-topics/consumer-healthcare/what-is-cardiovascular-disease/inflammation-and-heart-disease Inflammation and depression https://pmc.ncbi.nlm.nih.gov/articles/PMC4566946/ Cancer and chronic inflammation https://www.cancer.gov/about-cancer/causes-prevention/risk/chronic-inflammation Omega-3 supplements https://www.nccih.nih.gov/health/omega3-supplements-what-you-need-to-know   Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:58 Inflammation Basics 01:24 Acute Versus Chronic 03:29 Chronic Disease Link 03:52 Visceral Fat Driver 06:06 Sleep And Apnea 12:33 Food And Movement 16:02 Stress And Oral Health 18:17 Gut And Fiber 21:17 Toxins Autoimmune Infection 26:05 Inflammation Biomarkers 27:13 Inflammation Blood Markers 28:37 Ferritin Iron Balance 30:07 Metabolic Cardio Labs 32:08 Omega 3 Index Insights 34:07 Homocysteine Risks 34:58 Why Inflammation Matters 41:07 Lifestyle Fixes 46:24 Supplement Options 54:36 Medication Overview 57:36 Final Takeaways   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

Brian Boyd, Ph.D., is the William C. Friday Distinguished Professor in Education and Director of the Frank Porter Graham Child Development Institute at the University of North Carolina at Chapel Hill. A special educator by training, Dr. Boyd's research focuses on the development and implementation of evidence-based practices that bridge school, home, and community contexts. His scholarship also includes a significant focus on the development of rigorous outcome measures for autistic children, ensuring that progress can be accurately captured across diverse settings. Dr. Boyd's recent work addresses critical gaps in equity, specifically examining risk and cultural resilience for Black autistic children and their families. He currently serves as President of the International Society for Autism Research. His research program has been continuously funded by federal agencies such as the National Institutes of Health (NIH) and the Institute of Education Sciences (IES). He also serves on multiple scientific advisory boards dedicated to improving outcomes for historically underserved and under-researched communities.

Episode#334-Taped April 08, 2026 We talk about research articles and hot topics. There is a new plan that aims to track microplastics in our drinking water, the EPA says. This plan could lead to new regulations for federal water systems. The new White House budget plan would reduce HHS funding by billions. The National Institutes of Health(NIH) alone faces a $5B cut. Some of the articles discussed: Article-New White House budget plan would reduce HHS funding by billions-HealthDay News Article-New plan aims to track microplastics in U.S. drinking water, EPA says-HealthDay News It's All About Health & Fitness-Vicki Doe Fitness podcast Ranked on the Top 25 Midwest Fitness Podcasts to Listen to… with additional national recognition on the Top 100 US fitness podcast. Rate This Podcast Give us a 5-star review.  We appreciate you! Take this quick audience survey. Thank you! FREE Metabolic Makeover Masterclass Webinar Replay! Learn how to reset your metabolism, boost energy, and support sustainable weight loss using simple, science-backed strategies. Enroll in the Vicki Doe Fitness Academy to get instant access to the replay and begin your healthy living journey today. Vicki Doe Fitness-STORE Discover the Vicki Doe Fitness-STORE—your destination for stylish apparel, fitness gear, and wellness essentials like yoga mats, water bottles, candles, and premium supplements. Shop now and elevate your health journey! Resources *Note: Some of the resources below may be affiliate links, meaning Vicki Doe Fitness receives a commission (at no extra cost to you) if you use the link to make a purchase. Thank you for your support! Herbs and spices are the keys to delicious, flavorful, and sophisticated meals! FREE DOWNLOAD- Herbs and Spices Cheatsheet Let's get ECO-friendly.  Try ECOLunchbox.com ECOlunchbox specializes in stainless steel bento boxes, artisan fair trade lunch bags, napkins, snack sacks, and other eco-friendly lunchware. They are a certified green business.  ECOlunchbox is a consumer products company started by an eco mom in the San Francisco Bay Area. ECOLunchbox.com Go to our Resources page-   For the most recommended tools, you need to succeed on your healthy living journey!! Listen and share our podcast show- “It's All About Health & Fitness-” Vicki Doe Fitness Subscribe to Apple Podcast Subscribe on Stitcher Or on any of the platforms that you listen to your podcast! Watch & Subscribe on YouTube! Catch our latest health & wellness videos on YouTube at Vicki Haywood Doe – Vicki Doe Fitness YouTube-Vicki Haywood Doe-Vicki Doe Fitness

In this solo episode on androgenic alopecia, the host explains that hair loss is slow and progressive, driven largely by genetics and DHT-mediated miniaturization of follicles across the anagen, catagen, and telogen cycle, and stresses early detection using periodic photos of the temples, hairline/vertex, and crown. He frames hair growth as a "battle" between Wnt signaling (promotes growth and anagen entry via stem cell activation) and DHT signaling (suppresses Wnt and increases inhibitors like DKK, TGF-beta, and PGD2), noting advanced loss involves inflammation, fibrosis, and irreversible follicle loss. He reviews contributors like poor scalp blood flow, iron deficiency (most evidence), possible zinc/B12/folate deficiency, thyroid dysfunction, and insulin resistance, then covers treatments: finasteride (oral and topical) and dutasteride as DHT blockers with potential systemic side effects, plus minoxidil and microneedling (home vs professional) as key options, with add-ons like ketoconazole shampoo, PRP, red light, and cautions about anabolic steroids and high-dose testosterone increasing DHT pressure.   Hair loss diagnosis and treatment https://www.aad.org/public/diseases/hair-loss/treatment/diagnosis-treat Androgenetic alopecia https://medlineplus.gov/genetics/condition/androgenetic-alopecia/ DHT and WNT signaling https://pubmed.ncbi.nlm.nih.gov/29549490/ Finasteride https://medlineplus.gov/druginfo/meds/a698016.html Topical finasteride https://pmc.ncbi.nlm.nih.gov/articles/PMC6609098/ FDA warning on compounded topical finasteride https://www.fda.gov/drugs/human-drug-compounding/fda-alerts-health-care-providers-compounders-and-consumers-potential-risks-associated-compounded Post-finasteride syndrome https://pubmed.ncbi.nlm.nih.gov/35983808/ Dutasteride https://medlineplus.gov/druginfo/meds/a603001.html Minoxidil https://www.aad.org/public/diseases/hair-loss/treatment/diagnosis-treat Microneedling for hair loss https://pubmed.ncbi.nlm.nih.gov/23960389/ Ketoconazole shampoo https://pubmed.ncbi.nlm.nih.gov/31858672/ Topical caffeine https://pubmed.ncbi.nlm.nih.gov/39997270/ Pumpkin seed oil https://pubmed.ncbi.nlm.nih.gov/24864154/ PRP for hair loss https://pubmed.ncbi.nlm.nih.gov/30882509/ Red light / low-level light therapy https://pmc.ncbi.nlm.nih.gov/articles/PMC8906269/ Stem cells / exosomes for hair growth https://pmc.ncbi.nlm.nih.gov/articles/PMC12433634/ Iron, zinc, B12, and folate deficiencies https://pmc.ncbi.nlm.nih.gov/articles/PMC6380979/ Thyroid testing https://medlineplus.gov/thyroidtests.html Insulin resistance / metabolic syndrome https://medlineplus.gov/metabolicsyndrome.html Testosterone / TRT https://medlineplus.gov/druginfo/meds/a605020.html Tretinoin https://medlineplus.gov/druginfo/meds/a682437.html Anastrozole / Arimidex https://medlineplus.gov/druginfo/meds/a696018.html Anabolic steroids https://nida.nih.gov/research-topics/anabolic-steroids   Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:56 What Is Androgenic Alopecia 02:17 Hair Follicle Life Cycle 03:55 Miniaturization and Early Detection 06:51 DHT Basics and Other Causes 09:27 WNT Versus DHT Explained 13:10 Nutrients Thyroid and Insulin 16:26 Finasteride Benefits and Risks 19:21 Topical Finasteride and Dutasteride 25:01 Minoxidil Growth Booster 27:19 Microneedling for WNT Activation 30:21 Extra Treatments and Add Ons 37:04 Testosterone TRT and Steroids 40:16 Wrap Up and Key Takeaways   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

Dr. Allen Frances discusses how AI chatbots can provide effective support for everyday stress and mild symptoms, with tens of millions using them, but warns they can be dangerous for vulnerable groups—especially the very young, the very old, the socially isolated, and people with severe mental illness—potentially contributing to psychosis, suicide, or eating disorders. He argues harm is driven by chatbots being programmed to be pleasing and validating to maximize screen time, creating dependency and "echo chambers," and highlights major privacy risks and manipulation potential given extensive data collection and weak safeguards. Frances advocates a hybrid model where therapists and patients train chatbots as assistants aligned with treatment goals, and cautions about industry profit motives, limited regulation, scams, political propaganda, and broader societal risks. He also explains autism's overdiagnosis since DSM-IV's expansion (Asperger's/autism spectrum) and describes ADHD and autism as current fad diagnoses amplified by services and social media.   Dr. Allen Frances is a psychiatrist, author, and leading voice on psychiatric diagnosis, mental health, and the risks of overmedicalization. He is widely known for his work on the DSM-IV and for his book Saving Normal, which challenges the overdiagnosis and overtreatment of everyday life struggles. In this episode, he joins Dr. Mike Hart to break down the growing impact of AI chatbots on mental health, therapy, privacy, and clinical care. He explains when chatbot support may be helpful, why vulnerable users can be harmed, how AI could reshape psychotherapy, and why privacy with chatbots may be an illusion. He also discusses the overdiagnosis of autism and ADHD, the role of social media in self-diagnosis, and why false labels can change how people see themselves and their future. Books & Articles Saving Normal — Allen Frances Allen Frances mentions his book near the end of the episode. https://www.harpercollins.com/products/saving-normal-allen-frances Allen Frances — Psychiatric Times Articles He mentions his columns in Psychiatric Times about chatbots and psychiatry. https://www.psychiatrictimes.com/authors/allen-frances-md 1984 — George Orwell Referenced when comparing AI chatbots to "Big Brother." https://www.penguinrandomhouse.com/books/326569/1984-by-george-orwell-with-a-foreword-by-thomas-pynchon/ AI Tools & Companies Mentioned ChatGPT / OpenAI Discussed throughout the episode as a major AI chatbot example. https://chatgpt.com/ Claude / Anthropic Mentioned as one of the safer chatbot companies. https://www.anthropic.com/ Grok / xAI Mentioned during the discussion on chatbot safety. https://x.ai/grok Character.AI Mentioned as an AI companion/chatbot platform. https://character.ai/ Replika Mentioned as another AI companion/chatbot app. https://replika.com/ Signal Mentioned during the privacy and encryption discussion. https://signal.org/ TikTok Mentioned during the discussion of autism, ADHD, and self-diagnosis trends. https://www.tiktok.com/ AI Regulation & News References EU AI Act Mentioned during the discussion of Europe's stronger AI regulation. https://digital-strategy.ec.europa.eu/en/policies/regulatory-framework-ai Australia Social Media Age Restrictions Referenced when discussing age limits and children's chatbot/social media exposure. https://www.esafety.gov.au/about-us/industry-regulation/social-media-age-restrictions Kaiser Mental Health Workers AI Strike Mentioned during the discussion of therapists being concerned about AI replacing care. https://apnews.com/article/kaiser-mental-health-therapists-ai-2d05d37fd8be8f05491f0f15d97a78af Psychiatry, Diagnosis & Mental Health References DSM-5-TR Referenced in the discussion of DSM-IV, Asperger's, autism spectrum, and diagnostic expansion. https://www.psychiatry.org/psychiatrists/practice/dsm Autism Spectrum Disorder — NIMH Useful support link for the autism overdiagnosis discussion. https://www.nimh.nih.gov/health/topics/autism-spectrum-disorders-asd ADHD — CDC Referenced during the discussion of ADHD as a common modern diagnosis. https://www.cdc.gov/adhd/ SSRIs — FDA Mentioned during the discussion about antidepressant prescribing. https://www.fda.gov/drugs/information-drug-class/selective-serotonin-reuptake-inhibitors-ssris-information Hippocratic Oath Referenced through the idea of "first do no harm." https://www.britannica.com/topic/Hippocratic-oath Historical / Therapy References ELIZA Chatbot Referenced as the first chatbot and an early example of people bonding with machine-generated responses. https://dl.acm.org/doi/10.1145/365153.365168 Carl Rogers Mentioned because ELIZA was designed to imitate a Rogerian-style psychotherapist. https://www.britannica.com/biography/Carl-Rogers   Show Notes   00:00 Welcome to the Hart2Heart Podcast 00:49 Benefits vs Dangers 01:52 Engagement and Validation Trap 03:21 Who Is Most at Risk 04:19 When Chatbots Help 05:43 Hybrid Therapy Future 06:52 How to Train Assistants 08:47 Therapists Must Adapt 09:33 Healthcare Replacement Nightmare 11:15 Human Touch vs AI Limits 12:41 Suicide Risk and Lawsuits 14:43 SSRIs and Primary Care 16:56 Everyday Use and Vulnerables 19:12 Regulation and Kids 22:03 AI Power and Resource Costs 23:43 Deepfake Psychiatrists 24:30 Most Dystopian Takeover 25:50 AI Dependency Dangers 27:11 Why No One Pauses AI 28:41 EU Regulation Falling Behind 29:36 AI Hacking Breakthrough 30:38 Chatbot Privacy Myth 32:53 Protecting Yourself Online 35:26 Echo Chambers Manipulation 37:17 Scams Deepfakes Politics 40:44 Autism Overdiagnosis DSM 44:13 ADHD Fad Diagnosis Risks 45:53 Wrap Up Resources   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

In a wide-ranging interview, Dr. Sylvain Charlebois ("The Food Professor") discusses whether lab-grown (cellular) meat is overhyped, citing consumer acceptance, cost, and labeling as key barriers, though he found lab-grown chicken indistinguishable in taste and notes potential for nutrient customization. The conversation then turns to Canadian food inflation, arguing there is little evidence grocers are gouging consumers via higher margins, though grocers pressure suppliers through fees, affecting prices and supply-chain discipline. Charlebois contends food inflation is largely structural and policy-driven, pointing to trade barriers, carbon tax impacts, logistics, supply management, counter-tariffs, and the GST holiday's inflationary effect. He proposes solutions focused on competition, tax relief, logistics investment, and policy reform, and closes with a cautious view of ultra-processed food rhetoric, emphasizing consumer information over bans.   Dr. Sylvain Charlebois is a professor of food distribution and policy at Dalhousie University and director of the Agri-Food Analytics Lab, where his work focuses on food distribution, food policy, food security, and food safety. Widely known as "The Food Professor," he is one of Canada's most recognized voices on food inflation, grocery pricing, supply chains, and the future of food. His research has been featured in major outlets including The Economist, The New York Times, The Wall Street Journal, and The Globe and Mail, and he also hosts The Food Professor Podcast. In this episode, he breaks down what's really driving food prices in Canada, whether grocers are being unfairly blamed, the debate around lab-grown meat, and how ultra-processed foods and GLP-1 drugs are reshaping the food industry.   Sylvain / The Food Professor The Food Professor on X — https://x.com/FoodProfessor Sylvain Charlebois on LinkedIn — https://ca.linkedin.com/in/thefoodprofessor The Food Professor Podcast — https://the-food-professor.simplecast.com/ Food Tech / Salmon AquaBounty — https://aquabounty.com/our-salmon/why-aquabounty-salmon FDA AquAdvantage Salmon Fact Sheet — https://www.fda.gov/animal-veterinary/aquadvantage-salmon/aquadvantage-salmon-fact-sheet Sustainable Blue — https://www.sustainableblue.com/ Canada Food Policy / Data Canada Grocery Code of Conduct — https://canadacode.org/ Code of Conduct Page — https://canadacode.org/code/code-of-conduct/ Health Canada Front-of-Package Nutrition Symbol — https://www.canada.ca/en/health-canada/services/food-nutrition/nutrition-labelling/front-package.html Statistics Canada Household Income — https://www.statcan.gc.ca/hub-carrefour/quality-life-qualite-vie/prosperity-prosperite/household-income-revenu-menage-eng.htm CUSMA — https://www.international.gc.ca/trade-commerce/trade-agreements-accords-commerciaux/agr-acc/cusma-aceum/index.aspx?lang=eng GST/HST Holiday Page — https://www.canada.ca/en/services/taxes/child-and-family-benefits/gst-hst-holiday-tax-break.html David Dodge, Bank of Canada Profile — https://www.bankofcanada.ca/profile/david-dodge/ Companies / Brands Mentioned Loblaw Companies — https://loblaw.ca/ Sobeys — https://www.sobeys.com/ Walmart Canada — https://www.walmartcanada.ca/ CBC Organization Profile — https://federal-organizations.canada.ca/profil.php?OrgID=CBC&lang=en Johnson & Johnson — https://www.jnj.com/ McDonald's Canada — https://www.mcdonalds.com/ca/en-ca.html GLP-1 / Weight Loss Drugs Ozempic Canada — https://www.ozempic.ca/en_ca.html Wegovy Canada — https://www.wegovy.ca/en_ca.html Media / Podcast Reference The Joe Rogan Experience — https://open.spotify.com/show/4rOoJ6Egrf8K2IrywzwOMk   Show Notes 00:00 Welcome to the Hart2Heart Podcast  00:37 Lab Meat Hype Cycle 01:50 How Cultured Meat Works 03:06 Acceptance and Cost Barriers 04:46 Taste Test and Nutrition Tweaks 06:54 Vegans Vegetarians and Labeling 14:53 Canada Food Inflation Debate 15:57 Grocers Fees and Supplier Squeeze 17:40 Policy Roots and Middle Class Squeeze 21:06 Fixes Without More Spending 23:27 Supply Management Price Premiums 24:51 Politics Crises and Inflation Spending 26:53 Inflation And Taxes 27:38 Conservative Policy Impact 28:19 Grocer Margins And Manufacturing 30:05 GST Holiday Backfire 33:18 Media Blind Spots 35:05 Counter Tariffs Price Ripple 37:41 Carney Versus Poilievre 42:53 Media Subsidies And CBC 44:39 Ultra Processed Food Debate 48:54 Addiction Obesity And GLP1 51:30 Regulation Tradeoffs Wrap Up 52:51 Where To Follow Closing   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

What happened in 1993 still affects medicine today. That was the year women were required to be included in NIH-funded clinical trials, a shift that helped begin correcting decades of male-centered medical research. In this powerful conversation, Sharon Kedar CFA sits down with Jessica Federer, former Chief Digital Officer at Bayer and Managing Director of The Women's Health Fund, to explore why this moment matters not only for women's health, but for human health, innovation, and the future of medicine.They discuss how exclusion from research shaped diagnostics, drug dosing, autoimmune disease, heart health, cancer care, and why one of the world's largest multi-trillion dollar industries still has enormous opportunity ahead.This Episode Is For You If:- You want to understand why women's health impacts everyone- You're curious how clinical trials shape modern medicine- You care about innovation, investing, longevity, and better healthcare outcomesWhat You'll Learn:- Why women were historically excluded from many clinical trials- How 1993 changed medical research standards- Why better science creates better care for everyoneKey Takeaways- Clinical research has historically relied heavily on male data, creating downstream gaps in care.- Including women in research improves diagnostics, treatment, safety, and outcomes across medicine.- Women's health may be one of the greatest innovation opportunities of our time.Connect with Sharon:Connect with Sharon on LinkedIn: https://www.linkedin.com/in/sharonkedar/Learn more about Innovate and Elevate: https:// innovateandelevatepodcast.comSubscribe to Innovate and Elevate on YouTube: https://www.youtube.com/channel/UCuWi1O9RBaPMYuCkKszPYVAJoin the newsletter to receive the latest episodes in your inbox: https://innovateandelevatepodcast.com/emailConnect with Jessica Federer:- Instagram: https://www.instagram.com/jjfeds- LinkedIn: https://www.linkedin.com/in/jessicafederer- TikTok: https://www.tiktok.com/@jessica.federer?_r=1&_t=ZP-95ZSDLDRyyF- YouTube: https://youtube.com/@jjfeds?si=bX8_ii-GccsfXHN8Organizations, resources and citations referenced:Bayer: https://www.bayer.com/en/National Institutes of Health (NIH): https://www.nih.gov/U.S. Food and Drug Administration: https://www.fda.gov/Jennifer Doudna: https://vcresearch.berkeley.edu/faculty/jennifer-doudnaThe content shared in this episode is for informational purposes only and does not constitute medical, financial, or investment advice. Please seek guidance from your own qualified professionals before making decisions.Timestamps(00:00) Welcome Jessica Federer(00:50) Why Jessica cares deeply about women's health(02:10) Why 1993 was a turning point in clinical trials(04:33) NIH rules requiring women in funded research(08:28) Why women spend more years in poorer health(12:08) Mammograms, heart disease, and missed opportunities(15:36) Why cancer treatment may look barbaric in hindsight(18:53) Why top talent is moving into women's health(21:13) Autoimmune disease and the need for better systems(25:29) The next frontier: brain health and hormone scienceAbout Our Guest: Jessica Federer is a trailblazer and market builder. She was the first female chief digital Officer in the global pharmaceutical industry. She now sits on public and private boards, convenes the Health of Women Investor Summit and is the managing director of the Women's Health Fund. She also serves on the Yale IRB and the Yale Blavatnik Fund advisory.About Sharon: Sharon Kedar is a co-founder and partner at Northpond Ventures, a multi-billion-dollar science-driven venture capital firm. Her extensive career includes leadership roles at Sands Capital and McKinsey & Company, and she is a published author on personal finance. As the host of the Innovate and Elevate podcast, she passionately advocates for menopause care and HRT (hormone replacement therapy), challenging the silence around human health XX (also known as women's health). She aims to help women navigate midlife and achieve longevity by aging with power. Sharon holds an MBA from Harvard Business School and is a CFA charter holder. She lives in the Washington, DC area with her husband, Greg, their three kids, and their dog Bo.This podcast is produced by Brave Moon Podcasts: https://www.bravemoonpodcasts.com/

Dr. Mike Hart interviews Dr. Russell Kennedy about chronic anxiety as a childhood safety adaptation that never turns off, driven more by a body-based "alarm" than by thinking. Kennedy explains why understanding anxiety and talk-based cognitive approaches often have limited effect because subcortical systems communicate through feeling; alarm sensations trigger the mind to generate worries, which can become dopamine-reinforced and addictive. He discusses sensitivity (often cited as 15–20% of the population), modern stressors like smartphones and social media reducing discomfort tolerance, and high-functioning anxiety in high achievers and physicians, with sleep as a key regulation marker. Kennedy emphasizes reconnecting mind and body and adult self with younger self using somatic techniques (body scanning, hand placement, "sensation without explanation," and the SHOULD acronym), notes trauma can occur without an overtly traumatic life, links dysregulated autonomic states to varied symptoms, and shares rapid tools like the physiological sigh and alternate nostril breathing, plus his "Sanity" app and AnxietyMD resources. Dr. Russell Kennedy is a physician, author, and anxiety expert whose work explores the deeper roots of chronic anxiety, especially the role of childhood stress, nervous system dysregulation, and the body's stored alarm response. In this episode, he explains why anxiety is not just a thinking problem but a feeling problem, how worry becomes a coping pattern that keeps people stuck, why high performers often live in a state of hidden dysregulation, and how self-connection, somatic awareness, and better sleep can help break the cycle. Through a blend of clinical experience, neuroscience, and personal insight, Kennedy helps listeners better understand where anxiety comes from and what it actually takes to heal it at the root.   Official site: https://www.dr-russ.com/ Instagram: https://www.instagram.com/theanxietymd/ YouTube: https://www.youtube.com/c/DrRussellKennedyTHEANXIETYMD   Therapies Mentioned Internal Family Systems (IFS): https://ifs-institute.com/ Somatic Experiencing / somatic therapy: https://traumahealing.org/ Physiological sigh: https://www.hubermanlab.com/newsletter/breathwork-protocols-for-health-focus-stress Alternate nostril breathing: https://www.health.harvard.edu/healthy-aging-and-longevity/alternate-nostril-breath   Pain / Neuroplasticity Resources Alan Gordon / Pain Psychology Center: https://painpsychologycenter.com/our-team Pain Reprocessing Therapy: https://www.painreprocessingtherapy.com/   Experts Mentioned David Goggins: https://davidgoggins.com/ Joseph LeDoux: https://www.joseph-ledoux.com/ Dr. Ethan Russo: https://ethanrusso.org/ Clinical endocannabinoid deficiency paper (PubMed): https://pubmed.ncbi.nlm.nih.gov/15159679/   Show Notes 00:00 Welcome to the Hart2Heart Podcast 01:19 Anxiety Starts in the Body 03:17 Sensitivity and Modern Stress 05:58 The Dopamine Worry Loop 08:08 Self Connection Over Self Punishment 09:09 High Functioning Anxiety and Burnout 12:41 Redefining Success Internally 17:19 Discipline vs Dysregulation 21:46 Mind Body Child Separation 27:10 Finding the Alarm Sensation 29:16 Somatic Steps to Soothe Alarm 33:18 Why We Should Say Alarm 35:07 Medicine Limits and SSRIs 35:36 Medicine Misses Root Causes 36:57 Trauma Behind Weird Symptoms 38:58 Fibro IBS and Nervous System 42:31 Forgiveness and Doctor Burnout 50:51 Biohacking Anxiety Spiral 56:56 Somatic Healing and Spirit 01:02:50 Psychedelics Need Foundation 01:03:39 Physiological Sigh Tools 01:06:24 App Plug and Farewell   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

Last time on The Normals, we learned that in the 1950s, the National Institutes of Health (NIH) wanted to recruit many healthy volunteers for basic research. Two peace churches, the Mennonites and the Church of the Brethren, had an excess of healthy human volunteers. The “Normals” recruited from these Anabaptist churches were surprisingly happy, even as they went through sometimes painful procedures. In this follow-up episode, we hear about how the sources of normal human subjects changed in the 1960s and why NIH researchers felt they needed to expand their search for normal people. We also learn about the first death in the program and the shifting motives on the parts of the researchers and volunteers. Final episode drops next Tuesday, April 21. All Normals episodes In this episode: Laura Stark, history professor at the Center for Medicine, Health, and Society at Vanderbilt University Ken Naas, former Normal patient Cindy Jansen, former Normal patient Dale Horst, former Normal patient Sarah Crespi, Science Podcast senior host and producer Additional resources: The Normals: A People's History of Modern America in Five Human Experiments by Laura Stark Learn more about your ad choices. Visit megaphone.fm/adchoices

  Get Dr. Vonda's insights Want to understand what's happening in your body — and what to do next? Each week, Dr. Vonda shares science-backed guidance on strength, bone health, muscle, and longevity — the same way she speaks to her patients. Clear. Practical. No noise. Join the newsletter: https://manage.kmail-lists.com/subscriptions/subscribe?a=YqJKtR&g=Ww3gx3& I sat down with Dr. Florence Comite, the original gangster of precision medicine, who has been treating every patient as an "N of 1" for over 30 years. She pioneered Women's Health at Yale in 1992 and has spent her career proving that your genes are not your destiny. We go deep into what it actually takes to reverse biological aging, not slow it, reverse it. What we cover: - The five biomarkers that are suboptimal in nearly every patient, and why your doctor is probably not testing all of them. - Why "normal" lab values are not the same as optimal, and how that gap is silently costing you your health. - Why testosterone is the most underprescribed hormone in women's health, and what you lose without it. - How epigenetics means your lifestyle is rewriting your genetic destiny every single day. Why sleep, not exercise, is the foundation everything else is built on. About Dr. Florence Comite: Florence Comite, MD, physician-scientist, endocrinologist, and global authority on healthy longevity, is founder of the Comite Center for Precision Medicine & Healthy Longevity in New York, Palo Alto, and Miami Beach. A Yale School of Medicine graduate and faculty member for twenty-five years, Dr. Comite held triple appointments in Endocrinology (Internal Medicine and Pediatrics) and Reproductive Endocrinology (Gynecology and Andrology). As a clinical investigator, she developed research and patented therapies at the National Institutes of Health (NIH) and Yale. In 1992, she pioneered the nation's first center for women's health at Yale, redefining integrative care for women. Dr. Comite also founded the first physician-led artificial intelligence app. Trained on decades of her proprietary real-world research, it's a powerful personalized tool to help people optimize their healthspan. Connect with Dr. Florence Comite: Website: www.comitemd.com Instagram: https://www.instagram.com/drflorencecomite/ LinkedIn: https://www.linkedin.com/in/drflorencecomite/ TikTok: https://www.tiktok.com/@drflorencecomite/ X (Twitter): https://x.com/FlorenceComite

Last time on The Normals, we learned that in the 1950s, the National Institutes of Health (NIH) wanted to recruit many healthy volunteers for basic research. Two peace churches, the Mennonites and the Church of the Brethren, had an excess of healthy human volunteers. The “Normals” recruited from these Anabaptist churches were surprisingly happy, even as they went through sometimes painful procedures. In this follow-up episode, we hear about how the sources of normal human subjects changed in the 1960s and why NIH researchers felt they needed to expand their search for normal people. We also learn about the first death in the program and the shifting motives on the parts of the researchers and volunteers. Final episode drops next Tuesday, April 21. All Normals episodes In this episode: Laura Stark, history professor at the Center for Medicine, Health, and Society at Vanderbilt University Ken Naas, former Normal patient Cindy Jansen, former Normal patient Dale Horst, former Normal patient Sarah Crespi, Science Podcast senior host and producer Additional resources: The Normals: A People's History of Modern America in Five Human Experiments by Laura Stark Learn more about your ad choices. Visit megaphone.fm/adchoices

How do we know what's normal in a person? In the early 1950s, the National Institutes of Health (NIH) set out to do something unprecedented. It wanted to start studying normal humans on a grand scale. It had pretty much everything in place: It had the building, it had recruited all of these amazing researchers—it was the healthy human bodies NIH didn't have. How do we know what's normal in a person? In the early 1950s, the U.S. National Institutes of Health (NIH) set out to do something unprecedented. It wanted to start to study normal humans on a grand scale. It had pretty much everything in place: It had the building, it had recruited all of these amazing researchers—it was the healthy human bodies NIH didn't have. When the healthy subjects arrived, experimenters tested LSD, sleep devrivation, rice-only diets, and more risky intervetions on them. Where it found those volunteers and what happened next is the story of The Normals.  Starting on 7 April, the Science Podcast will be releasing a new three-part limited series called The Normals. We'll hear from some of the original “Normals,” follow the program through the decades, and see what's happening with healthy human subject research today. All Normals episodes Appearing in this episode: Laura Stark, history professor at the Center for Medicine, Health, and Society at Vanderbilt University Dale Horst, former Normal patient Shirley Burry Geissinger, former Normal patient Sarah Crespi, Science Podcast senior host and producer Additional resources: The Normals: A People's History of Modern America in Five Human Experiments by Laura Stark   Learn more about your ad choices. Visit megaphone.fm/adchoices

How do we know what's normal in a person? In the early 1950s, the National Institutes of Health (NIH) set out to do something unprecedented. It wanted to start studying normal humans on a grand scale. It had pretty much everything in place: It had the building, it had recruited all of these amazing researchers—it was the healthy human bodies NIH didn't have. How do we know what's normal in a person? In the early 1950s, the U.S. National Institutes of Health (NIH) set out to do something unprecedented. It wanted to start to study normal humans on a grand scale. It had pretty much everything in place: It had the building, it had recruited all of these amazing researchers—it was the healthy human bodies NIH didn't have. When the healthy subjects arrived, experimenters tested LSD, sleep devrivation, rice-only diets, and more risky intervetions on them. Where it found those volunteers and what happened next is the story of The Normals.  Starting on 7 April, the Science Podcast will be releasing a new three-part limited series called The Normals. We'll hear from some of the original “Normals,” follow the program through the decades, and see what's happening with healthy human subject research today. All Normals episodes Appearing in this episode: Laura Stark, history professor at the Center for Medicine, Health, and Society at Vanderbilt University Dale Horst, former Normal patient Shirley Burry Geissinger, former Normal patient Sarah Crespi, Science Podcast senior host and producer Additional resources: The Normals: A People's History of Modern America in Five Human Experiments by Laura Stark   Learn more about your ad choices. Visit megaphone.fm/adchoices

Dr. Mike Hart interviews elite runner Brady Holmer about endurance training, VO2 max physiology, and common misconceptions. Holmer explains that zone 2 builds the aerobic base and enables high training volume with less fatigue, notes heart-rate zones are ideally defined by lactate thresholds, and says he primarily uses perceived exertion rather than lactate or heart rate during training. He advises against guiding workouts by wearable HRV scores, arguing accurate HRV requires standardized morning measurements and that wearable data can create a nocebo effect; trends may be informative, but subjective feel should come first. They discuss polarized vs pyramidal training and typical 80/20 intensity distributions, effective session durations, mechanisms limiting VO2 max (central vs peripheral), and why Norwegian 4x4 intervals work by maximizing time near 85–90% max heart rate. They cover breathing/nose breathing, inspiratory muscle training, sauna/hot baths as performance adjuncts, nutrition timing of carbohydrates, and supplements including beetroot, beta-alanine, urolithin A, and post-exercise ketones. Brady Holmer is an endurance-focused performance expert and elite runner whose work explores the science and practice of aerobic fitness, VO2 max, recovery, and smarter cardio training. In this episode, he explains how zone 2 training builds the foundation for endurance, why HRV and wearable data should be interpreted carefully, and how protocols like Norwegian 4x4 can improve performance when used in the right context. Through a blend of long-term training experience, research literacy, and practical coaching insight, Holmer helps listeners better understand how to train harder, recover smarter, and think more clearly about what actually improves cardiovascular fitness.   Training & Cardio Zone 2 Cardio Overview (Cleveland Clinic): https://health.clevelandclinic.org/zone-2-cardio   Lactate / Threshold-Based Training Threshold zones review (PMC): https://pmc.ncbi.nlm.nih.gov/articles/PMC6537749/   Lactate-guided threshold interval training (PMC): https://pmc.ncbi.nlm.nih.gov/articles/PMC10000870/   Norwegian 4x4 Classic VO2 max paper (PubMed): https://pubmed.ncbi.nlm.nih.gov/17414804/   4x4 protocol heart-rate response study (PMC): https://pmc.ncbi.nlm.nih.gov/articles/PMC7399937/   Polarized Training Meta-analysis / review (PubMed): https://pubmed.ncbi.nlm.nih.gov/38717713/   Older landmark paper (PubMed): https://pubmed.ncbi.nlm.nih.gov/24550842/   Pyramidal Training Pyramidal vs. polarized study (PMC): https://pmc.ncbi.nlm.nih.gov/articles/PMC9299127/   HRV & Wearables   Marco Altini Official site: https://www.marcoaltini.com/ HRV4Training: https://www.hrv4training.com/   HRV Measurement / Use HRV4Training article with Marco Altini: https://www.hrv4training.com/blog2/heart-rate-variability-hrv-training-with-dr-marco-altini-how-to-exercise-using-hrv   Oura Ring Official: https://ouraring.com/   WHOOP Official: https://www.whoop.com/   Experts & Writing   Dr. Andy Galpin Official site: https://www.andygalpin.com/   Brady Holmer Substack profile: https://substack.com/@bradyholmer   Physiologically Speaking: https://www.physiologicallyspeaking.com/   Supplements & Recovery Exercise / Performance Supplements NIH overview: https://ods.od.nih.gov/factsheets/ExerciseAndAthleticPerformance-HealthProfessional/   Creatine Cleveland Clinic overview: https://my.clevelandclinic.org/health/treatments/17674-creatine   Beta-Alanine NIH consumer overview: https://ods.od.nih.gov/factsheets/ExerciseAndAthleticPerformance-Consumer/   ISSN position stand (PMC): https://pmc.ncbi.nlm.nih.gov/articles/PMC4501114/   Beetroot / Dietary Nitrate Review (PMC): https://pmc.ncbi.nlm.nih.gov/articles/PMC4008816/   Meta-analysis (PubMed): https://pubmed.ncbi.nlm.nih.gov/23580439/   Urolithin A Mitopure / official: https://www.mitopure.com/   Altitude training camp study (PMC): https://pmc.ncbi.nlm.nih.gov/articles/PMC12628386/   Exogenous Ketones Ketone-IQ official: https://ketone.com/   Post-exercise ketone monoester and EPO study (PubMed): https://pubmed.ncbi.nlm.nih.gov/36449571/   Post-exercise ketones improved endurance training adaptations study (PubMed): https://pubmed.ncbi.nlm.nih.gov/41757674/   Show Notes 00:00 HRV Training Myth 00:59 Zone Two Benefits 02:11 Finding True Zone Two 03:59 RPE Over Wearables 06:27 HRV Done Right 12:06 80 20 Training Split 15:23 Zone Two Session Length 18:37 Cardio Adaptation Science 24:03 Norwegian 4x4 Explained 30:30 Sports Versus Machines 32:54 Leg Day Timing Tips 34:58 Best Leg Exercises 38:21 Nordic Curl Reality Check 39:11 Portable Nordic Setup Tips 39:51 Biggest Running Mistake 40:18 Nose Breathing Zone Two 42:16 Breathing Tools And Myths 43:08 Inspiratory Muscle Training 44:51 How Much Benefit Really 46:27 Sauna For VO2 Max 48:35 Heat Mimics Altitude 50:59 Sauna Fertility Debate 52:54 Red Light Therapy Reality 54:30 Carbs Fuel The Work 56:25 Timing Carbs Around Training 57:52 Best Carb Food Choices 59:41 Supplements For Cardio 01:00:20 Creatine Beta Alanine Beetroot 01:02:16 Urolithin A Breakthrough 01:05:01 Ketones After Training 01:07:31 Other Supplements And Caffeine 01:09:07 SARMs Peptides And Doping 01:10:10 VO2 Max And Longevity 01:10:49 Wrap Up And Where To Follow   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

Dr. R. Douglas Fields is Chief of the Nervous System Development and Plasticity Section at the National Institutes of Health (NIH) and Adjunct Professor in the Neuroscience and Cognitive Science Program at the University of Maryland, College Park. In addition, Doug is the author of numerous books and magazine articles about the brain, including the recently released book Electric Brain: How the New Science of Brainwaves Reads Minds, Tells Us How We Learn, and Helps Us Change for the Better. Doug studies how the brain develops and the mechanisms involved in changes to the brain's structure and function (plasticity). He is particularly interested in how experience regulates development and plasticity in the brain, as well as the mechanisms at a cellular level that are involved in learning. When he's not doing research or writing about science, Doug enjoys rock climbing, mountain climbing, building acoustic guitars, and making his own beer and wine. He received his B.A. in biology from the University of California, Berkeley, his M.A. degree in marine biology from San Jose State University, and his Ph.D. degree in marine biology from the University of California, San Diego, working jointly in the Medical School and Scripps Institution of Oceanography. Afterwards, Doug conducted postdoctoral research at Stanford University, Yale University, and the NIH before starting his research laboratory at the NIH in 1994. Doug is an elected Fellow of the American Association for the Advancement of Science, and he is the Founder and Editor-In-Chief of the scientific journal Neuron Glia Biology. In our interview, Doug tells us more about his life and science.

Dr. Tommy Wood discusses evidence that stimulants can help people with ADHD but may worsen complex cognitive performance in non-ADHD users despite feeling more focused. He outlines an ideal brain-health day centered on consistent sleep opportunity, morning caffeine timed to protect sleep, nutrient-dense meals (protein, B vitamins, omega-3s, fiber, antioxidants), frequent movement to break up sedentary time, and structured exercise including cardio, resistance training, HIIT (notably Norwegian 4x4), and open-skill sports for added cognitive benefits. He emphasizes bright morning light and darkness at night for circadian strength, notes optic-flow/nature exposure as helpful but not required, and says electrolytes/salt needs are individual. The conversation covers cognitive decline and bioenergetics/mitochondria, critiques "type 3 diabetes" as oversimplified, reviews mixed evidence for ketones, and addresses supplements (omega-3s, vitamin D, saffron, creatine, polyphenols). Screens can help or harm depending on use and what they displace. Wood promotes his book, "The Stimulated Mind," out March 24.   Dr. Tommy Wood is a physician-scientist and brain health expert who helps people better understand how to improve cognition, protect memory, and reduce long-term dementia risk. With a focus on exercise, sleep, nutrition, and brain energetics, he explores the practical habits that support focus, processing speed, recovery, and healthy cognitive aging. Dr. Wood is known for translating complex neuroscience into clear, actionable advice, while challenging oversimplified ideas around stimulants, supplements, and modern brain optimization. Through his research, speaking, and new book The Stimulated Mind, Dr. Wood teaches people how to create the right conditions for better brain function across the lifespan. His work empowers listeners to think of brain health as something trainable—shaped by movement, sleep, learning, and the quality of the inputs we give our minds every day.   Books & Main Episode Resources The Stimulated Mind Official book page: https://www.drtommywood.com/stimulated-mind Publisher page: https://www.penguinrandomhouse.com/books/751292/the-stimulated-mind-by-dr-tommy-wood/   Dr. Tommy Wood Official website: https://www.drtommywood.com/ Instagram: https://www.instagram.com/drtommywood/   Podcasts, People & Platforms The Diary of a CEO Official show page: https://stevenbartlett.com/doac/ Joe Rogan Experience Official site: https://www.joerogan.com/ Spotify show page: https://open.spotify.com/show/4rOoJ6Egrf8K2IrywzwOMk   Dr. Rhonda Patrick / FoundMyFitness Official site: https://www.foundmyfitness.com/ About Dr. Rhonda Patrick: https://www.foundmyfitness.com/about-dr-rhonda-patrick   Medications & Prescription Drugs Mentioned Provigil (modafinil) DailyMed label: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e16c26ad-7bc2-d155-3a5d-da83ad6492c8 Vyvanse (lisdexamfetamine) DailyMed label: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=704e4378-ca83-445c-8b45-3cfa51c1ecad Concerta (methylphenidate) Official prescribing info: https://www.jnjlabels.com/package-insert/product-monograph/prescribing-information/CONCERTA-pi.pdf Adderall DailyMed label: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f22635fe-821d-4cde-aa12-419f8b53db81 Adderall XR DailyMed label: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=aff45863-ffe1-4d4f-8acf-c7081512a6c0 Aricept (donepezil) FDA label: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020690s042,021720s014,022568s011lbl.pdf Hydration / Electrolytes LMNT Official site: https://drinklmnt.com/   Research, Labs & Studies Mentioned   COSMOS Trial Official site: https://cosmostrial.org/ ClinicalTrials.gov: https://clinicaltrials.gov/study/NCT03035201   Institute for Human and Machine Cognition (IHMC) Official site: https://www.ihmc.us/   Jonathan Little Lab (UBC) Faculty page: https://hes.ok.ubc.ca/about/contact/jonathan-little/ Lab site: https://emil.ok.ubc.ca/   Show Notes 00:00 Stimulants Backfire 00:56 Plan Sleep First 02:33 Caffeine Timing 04:24 Brain Food Basics 05:12 Move All Day 06:00 Workouts That Help 07:26 Social Connection Matters 08:36 Sunlight Optic Flow Hydration 13:31 Exercise Types Compared 16:02 HIIT Lactate Brain Boost 18:18 Open Skill Sports 21:45 ADHD Meds Long Term 26:51 Which Med Is Best 27:59 Cognitive Decline Energy 28:27 Brain Energy Risk Factors 29:04 Stimulus Drives Brain Health 30:57 Type Three Diabetes Debate 33:42 Ketones and Cognition 37:13 Mitochondria and Decline 38:42 Omega Three Practical Dosing 41:45 Vitamin D and Dementia Risk 43:13 Saffron Hype Check 45:03 Creatine for the Brain 50:28 Polyphenols Diet vs Pills 52:41 Screens AI and Brain Use 55:31 Book Plug and Wrap Up   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

Good morning from Pharma Daily: the podcast that brings you the most important developments in the pharmaceutical and biotech world. Today, we delve into a series of significant advancements and strategic shifts currently shaping the landscape of these industries.To start, let's discuss a remarkable development in therapeutic treatments. UCB's Bimzelx has demonstrated superior efficacy over AbbVie's Skyrizi in treating psoriatic arthritis, as revealed by a head-to-head phase 3b clinical trial. This finding not only extends UCB's winning streak in psoriasis treatment but also positions Bimzelx as a competitive alternative in the immunology sector. The implications of this are profound, potentially influencing prescribing patterns and improving patient outcomes by offering an effective alternative for those with psoriatic conditions.In manufacturing news, Eli Lilly is making waves with its substantial $3 billion investment aimed at enhancing the global supply chain for Orforglipron, their oral GLP-1 receptor agonist. This move highlights a growing demand for GLP-1 therapies, crucial for managing type 2 diabetes and obesity. The strategic focus on oral therapies reflects a broader industry trend towards improving patient compliance compared to injectable alternatives, underscoring the importance of such innovative treatments in addressing widespread health issues. Additionally, Eli Lilly's commitment to investing $500 million into South Korea's biopharmaceutical sector signals the country's rising status as a hub for biopharmaceutical innovation and development, likely fostering collaborations and expediting novel therapeutics' development.Economically, there's compelling evidence of the impact public funding has on scientific advancement. A recent report by United for Medical Research revealed that National Institutes of Health (NIH) grants generated $94.15 billion in economic activity in 2025, supporting nearly 391,000 jobs. This underscores the dual role of public funding in advancing biomedical research and stimulating economic growth.On the regulatory front, Sandoz is making a strategic move to establish a standalone unit dedicated to biosimilars. As we enter what Sandoz describes as a 'golden decade' of patent expirations, this realignment reflects anticipation of expansion opportunities within the biosimilars market. Such preparations suggest increased competition and potentially more affordable biologic therapy options as major drugs lose patent protection.Technological advancements are further shaping industry operations. BD's partnership with Sinteco to automate pharmacy logistics in Europe is part of a broader push to integrate robotics into healthcare processes. This aligns with digital transformation trends across the sector aimed at improving efficiency and reducing human error. Meanwhile, Medtronic's former diabetes division Minimed has achieved European approval for its 780G insulin pump system, which integrates with Abbott's continuous glucose monitor (CGM). This approval is noteworthy for enhancing diabetes management through automation of insulin delivery based on real-time glucose monitoring, representing a significant step forward in closed-loop systems.A notable technological initiative comes from ARPA-H with their program focused on developing wearable biosensors under the Delphi initiative. These sensors aim to enhance personal health monitoring capabilities across various devices, aligning with trends towards personalized medicine and digital health technologies.Despite these positive strides, challenges persist. The closure of F5 Therapeutics highlights early-stage biotech struggles amid competitive pressures. Regulatory setbacks also continue to pose challenges; Novo Nordisk recently received an FDA warning letter following inspection issues at its U.S. headquarters.Collectively, these trends reflect an industry resiliently pursuSupport the show

The script explains why fiber is critical for gut and metabolic health, focusing on how soluble fiber is fermented in the colon to produce short-chain fatty acids (butyrate, propionate, acetate). It contrasts soluble fiber (forms a gel, lowers LDL by binding bile acids, slows glucose absorption, increases satiety, feeds the microbiome) with insoluble fiber (adds stool bulk, helps constipation). It highlights research showing 10 g/day psyllium husk (Metamucil) is linked to a 10% reduction in all-cause mortality and typically lowers LDL about 7–15%. Butyrate is emphasized as the primary fuel for colonocytes, supporting gut barrier integrity and potentially reducing colon cancer risk, while also affecting mitochondria, inflammation, and the brain. Propionate influences liver cholesterol production and satiety hormones, and acetate provides systemic energy. Practical supplementation "stacks," dosing ranges, food sources, GI side effects, and timing cautions (e.g., separating psyllium from minerals) are discussed.   Metamucil (psyllium husk fiber) — https://www.metamucil.com/   Psyllium husk (soluble fiber) — https://medlineplus.gov/druginfo/meds/a601104.html Psyllium husk (PubMed search) — https://pubmed.ncbi.nlm.nih.gov/?term=psyllium+husk   Soluble fiber (overview) — https://medlineplus.gov/dietaryfiber.html Insoluble fiber (overview) — https://medlineplus.gov/dietaryfiber.html   Inulin (prebiotic fiber) — https://pubmed.ncbi.nlm.nih.gov/?term=inulin+prebiotic+fiber   Acacia fiber / Gum arabic (prebiotic fiber) — https://pubmed.ncbi.nlm.nih.gov/?term=acacia+fiber+gum+arabic+prebiotic   Beta-glucan (oats/barley soluble fiber) — https://pubmed.ncbi.nlm.nih.gov/?term=beta-glucan+oats+LDL   Pectin (soluble fiber) — https://pubmed.ncbi.nlm.nih.gov/?term=pectin+soluble+fiber   Partially hydrolyzed guar gum (PHGG) — https://pubmed.ncbi.nlm.nih.gov/?term=partially+hydrolyzed+guar+gum   Resistant starch / Potato starch — https://pubmed.ncbi.nlm.nih.gov/?term=resistant+starch+potato+starch   Short-chain fatty acids (SCFAs) — https://www.ncbi.nlm.nih.gov/books/NBK557571/   Butyrate (SCFA) — https://pubmed.ncbi.nlm.nih.gov/?term=butyrate+short-chain+fatty+acid+colonocytes   LDL cholesterol (general) — https://medlineplus.gov/cholesterol.html   Magnesium (mineral supplement info) — https://medlineplus.gov/magnesium.html   Show Notes   00:00 Butyrate and Colon Health 00:49 Why Fiber Matters Now 02:28 How Fiber Is Digested 03:45 Soluble vs Insoluble Fiber 06:36 Gel Effect on Blood Sugar 07:36 How Soluble Fiber Lowers LDL 10:19 Short Chain Fatty Acids 101 11:32 Butyrate Deep Dive 16:40 Propionate and Liver Benefits 18:22 Acetate for Energy and Appetite 19:29 Best Fibers to Supplement 21:33 Dosing and Food Sources 24:44 Ideal Fiber Stack and Safety 28:37 Wrap Up and Next Steps   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

Dr. Roger McFillin argues that Western allopathic medicine and psychiatry have medicalized normal human suffering by reducing emotions to biological or chemical reactions, turning symptom checklists into fixed identities, and sustaining a drug-driven "sick care" system that creates lifelong customers. He contrasts this with viewing emotions as powerful energy meant to be moved into creation and transformation, cites psychoneuroimmunology, and warns that suppressing fear and distress with pharmaceuticals can worsen long-term outcomes. The conversation covers exposure-based approaches to unlearn fear, the role of media, social media, and advertising in provoking fear and keeping people in an unconscious "drift" state, and the importance of intentional stillness, solitude (distinct from loneliness), prayer or silent meditation, and reducing phone use—especially at the start of the day—to become more conscious and intentional.    McFillin discusses how diagnostic labels like depression and anxiety shape identity, limit choices, and contribute to chronicity and polypharmacy. He contrasts PTSD with post-traumatic growth, emphasizing processing trauma memories, facing avoided situations, challenging overgeneralized threat beliefs, and practicing forgiveness and self-compassion while also taking ownership where appropriate. They also discuss the perceived harms of the "toxic masculinity" concept, men's wellbeing, the loss of wise elders, and how men often bond and cope through shared activities. Dr. Roger McFillin is a clinical psychologist and trauma recovery expert who challenges the medicalization of normal human emotions. With a focus on emotional resilience and personal growth, he specializes in exposure therapy and psychoneuroimmunology, exploring the connection between mind, emotions, and immune health. Dr. McFillin advocates for self-regulation and transforming emotional energy into healing, critiquing the overuse of pharmaceuticals in modern mental health treatment. Through his Substack, Radically Genuine, and podcast, Dr. McFillin educates individuals on overcoming fear, achieving stillness, and reconnecting with their true selves. His work empowers people to shift from a victim mindset to one of active growth, using trauma as a catalyst for resilience and positive change.   Science & Medicine   Psychoneuroimmunology   Overview & science (NIH): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130991/   Exposure Therapy   Wikipedia overview: https://en.wikipedia.org/wiki/Exposure_therapy   Cleveland Clinic explanation: https://my.clevelandclinic.org/health/treatments/25067-exposure-therapy   Anxiety & OCD exposure-based approaches (IOCDF): https://iocdf.org/about-ocd/treatment/erp/   Heart Coherence   HeartMath Institute overview: https://www.heartmath.org/heart-coherence/   Psychiatric Diagnosis & DSM   Critique of DSM and diagnostic categories: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195174/   Psychiatric diagnosis controversies: https://www.apa.org/monitor/2013/04/diagnosis   Psychology & Healing   Post-Traumatic Growth vs. PTSD   Scientific overview of post-traumatic growth: https://www.apa.org/monitor/2014/01/psychological-recovery   Journal article on PTG vs PTSD: https://www.sciencedirect.com/science/article/abs/pii/S0272735814000412   Forgiveness and Healing   Psychology Today on forgiveness: https://www.psychologytoday.com/us/basics/forgiveness   Research evidence on forgiveness and wellbeing: https://journals.sagepub.com/doi/10.1177/1745691614568356   Self‑Healing Practices   Grounding / Earthing   What is grounding/earthing? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378297/   PEMF (Pulsed Electromagnetic Field) Therapy   Basics of PEMF therapy: https://www.health.harvard.edu/pain/pulsed-electromagnetic-field-therapy   Meditation & Stillness   Mindfulness & stillness research: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422583/   Psychology Today on solitude and healing: https://www.psychologytoday.com/us/blog/hide-and-seek/201209/finding-solitude-its-benefits-and-challenges   Cultural & Media Influence   Mind Control & Fear Provocation   The psychology of fear in media messaging: https://www.frontiersin.org/articles/10.3389/fpsyg.2020.566245/full   Media influence and persuasion research: https://www.communicationtheory.org/agenda-setting-theory/   Toxic Masculinity   Research overview on toxic masculinity: https://www.apa.org/advocacy/health-men/guidelines   What toxic masculinity means: https://www.psychologytoday.com/us/blog/the-masculine-mind/201802/what-toxic-masculinity   Dr. Roger McFillin Content   Substack (Radically Genuine): https://drmcmillan.substack.com   Show Notes 00:00 Emotions as Energy 00:33 Medicalizing Suffering 02:44 Exposure Beats Suppression 05:18 Fear and Mind Control 10:21 Stillness vs Loneliness 14:47 Simple Stillness Practices 20:12 Morning Intention Rituals 25:56 Labels and Identity Traps 31:26 Systemic Treatment Harm 32:53 Depression Label Identity 35:08 Sadness Versus Pathology 36:10 PTSD And Growth 38:24 Processing Trauma Fully 41:44 Practical Recovery Steps 45:48 Forgiveness And Ownership 50:37 Toxic Masculinity Debate 56:12 Men Friendship And Elders 01:01:05 Closing Plugs Farewell 38:24 How PTSD Develops 41:44 Practical Trauma Recovery 45:48 Forgiveness and Ownership 50:37 Toxic Masculinity Debate 56:12 Male Friendship and Elders 01:01:05 Closing and Where to Follow   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

February is Heart Health Month, and in this episode of Making Shift Happen, we're breaking down how busy gravel cyclists and mountain bikers can build a stronger heart, without adding more stress to your schedule. Backed by research from the National Heart, Lung, and Blood Institute (NHLBI) and the National Institutes of Health (NIH), this episode covers practical, science-supported habits that improve cardiovascular health and cycling performance. You'll learn how to: Improve heart health through smart training and daily movement Fuel your body with simple, heart-healthy meals Use sleep and recovery to boost endurance and power Manage stress for better performance and long-term health Understand why knowing your health numbers matters Whether you're juggling work, family, and training – or just trying to ride stronger without burnout – this episode gives you realistic tools to support your heart, body, and mindset. Check out these other relevant episodes: 236. How to Stay Motivated When Winter Days Get Short and Cold 231. How to Maintain Bike Fitness Without Losing Motivation this Winter 196. 5 Nutrition and Fitness Tips for Winter    Do you have nutrition and fitness goals? I’m your coach!  If you’re ready to finally make some sustainable progress, feel strong and powerful on every climb uphill, feel less pain, perform better, or lose a few extra pounds, then apply to work with me by clicking here. I work with people just like you, and you’ll see results a helluva lot faster than on your own. #ShredStrong: Our Month Starts on Monday, March 2, 2026! #ShredStrong is my year-round strength training program for mountain bikers and gravel cyclists. You can join any time you want, but why not now?! Learn more about the program and sign-up HERE!  Keywords: heart health for cyclists, gravel cycling training, mountain bike fitness, endurance athlete heart health, cycling nutrition, cycling recovery, busy athlete training, cardiovascular health cycling, Shred Strong podcast

This episode explores tadalafil (Cialis) as a potential longevity drug, though no randomized human trials prove it extends lifespan. Cialis works by blocking PDE5, enhancing nitric oxide signaling, and improving blood flow through vasodilation. Originally approved for pulmonary hypertension, it's also used for erectile dysfunction and BPH. Its 36-hour half-life makes it superior to Viagra for continuous longevity effects.   The host frames vascular aging and endothelial dysfunction as key drivers of age-related diseases (heart disease, stroke, dementia, kidney disease). Observational data shows Cialis users have 44% lower mortality, fewer cardiovascular events, reduced dementia risk, and lower mortality in diabetics. Additional benefits include improved cardiac function, reduced infarct size, arrhythmia suppression, and regression of left ventricular hypertrophy. A 2024 meta-analysis found it lowers hemoglobin A1C, possibly via improved microvascular perfusion, insulin sensitivity, and mitochondrial function.   Cialis crosses the blood-brain barrier and may improve neurovascular coupling and hippocampal plasticity, potentially benefiting those with or at risk of dementia. Safety is generally good with long-term daily use (2.5–5 mg), though cautions include avoiding use with nitrates, low blood pressure, or certain retinal disorders. Common side effects are headache, nasal congestion, and acid reflux. The host recommends consulting a doctor and references potential synergy with telmisartan.   Tadalafil (Cialis) — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a604008.html](https://medlineplus.gov/druginfo/meds/a604008.html) Sildenafil (Viagra) — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a699015.html](https://medlineplus.gov/druginfo/meds/a699015.html)   Key mechanisms mentioned Nitric Oxide (NO) — NCBI Bookshelf: [https://www.ncbi.nlm.nih.gov/books/NBK554485/](https://www.ncbi.nlm.nih.gov/books/NBK554485/) Cyclic GMP (cGMP) — NCBI Bookshelf: [https://www.ncbi.nlm.nih.gov/books/NBK542234/](https://www.ncbi.nlm.nih.gov/books/NBK542234/)   Conditions mentioned in the episode Benign Prostatic Hyperplasia (BPH) — MedlinePlus: [https://medlineplus.gov/benignprostatichyperplasia.html](https://medlineplus.gov/benignprostatichyperplasia.html) Pulmonary Arterial Hypertension (PAH) — MedlinePlus: [https://medlineplus.gov/pulmonaryhypertension.html](https://medlineplus.gov/pulmonaryhypertension.html)   Blood pressure drug mentioned Telmisartan — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a601249.html](https://medlineplus.gov/druginfo/meds/a601249.html)   Other longevity / comparison drugs mentioned Metformin — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a696005.html](https://medlineplus.gov/druginfo/meds/a696005.html) Sirolimus (Rapamycin) — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a602026.html](https://medlineplus.gov/druginfo/meds/a602026.html)   Side-effect helper mentioned Ibuprofen (Advil) — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a682159.html](https://medlineplus.gov/druginfo/meds/a682159.html)   Dementia meds mentioned Donepezil (Aricept) — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a697032.html](https://medlineplus.gov/druginfo/meds/a697032.html) Amantadine — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a682064.html](https://medlineplus.gov/druginfo/meds/a682064.html)   Lab markers mentioned Hemoglobin A1C (HbA1c) test — MedlinePlus lab test: [https://medlineplus.gov/lab-tests/hemoglobin-a1c-hba1c-test/](https://medlineplus.gov/lab-tests/hemoglobin-a1c-hba1c-test/) Insulin in blood test — MedlinePlus lab test: [https://medlineplus.gov/lab-tests/insulin-in-blood/](https://medlineplus.gov/lab-tests/insulin-in-blood/)   People referenced (where the claims were mentioned) Huberman Lab (Dr. Andrew Huberman) — site: [https://www.hubermanlab.com/](https://www.hubermanlab.com/) Clip about low-dose tadalafil (2.5–5mg) — X post: [https://x.com/tbpn/status/2022350426394534334](https://x.com/tbpn/status/2022350426394534334) Bryan Johnson (Blueprint) — site: [https://blueprint.bryanjohnson.com/](https://blueprint.bryanjohnson.com/) Dr. David Sinclair (Harvard profile) — site: [https://sinclair.hms.harvard.edu/people/david-sinclair](https://sinclair.hms.harvard.edu/people/david-sinclair)   Show Notes   00:00 Welcome to the Hart2Heart Podcast. 01:56 What Cialis Is: PDE5 Inhibition, cGMP & Nitric Oxide Explained 03:43 Approved Uses & Origin Story: Pulmonary Hypertension, ED, and BPH 05:33 Why Cialis Over Viagra: 36-Hour Half-Life & 24/7 Vascular Benefits 06:52 Vascular Aging 101: Endothelium, Perfusion, and Why It Drives Disease 11:14 What the Human Data Shows: Observational Evidence for Mortality, CVD & Dementia 13:04 Mechanisms Deep Dive: Heart Protection, Heart Failure, and Anti-Atherosclerosis 15:02 Cialis for Diabetics: Lowering A1C and Improving Insulin Sensitivity 16:21 Brain Effects: Blood–Brain Barrier, Neurovascular Coupling & Dementia Potential 18:21 Safety, Who Should Avoid It, and Daily Longevity Dosing (2.5–5 mg) + Wrap-Up   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

In this podcast episode, an in-depth discussion is provided on the drug Telmisartan, commonly used for lowering blood pressure. The host elaborates on how it belongs to a class of medications known as angiotensin receptor blockers (ARBs) and stands out due to its 24-hour half-life and partial PPAR-gamma agonist activity.  The episode explores Telmisartan's potential benefits for longevity, including its properties that reduce cardiovascular mortality, renal decline, and metabolic issues. It also compares Telmisartan with other ARBs and addresses its unique ability to improve myocardial efficiency, reduce arterial stiffness, and support neuroprotection. Detailed explanations are given on technical concepts such as pulse pressure and its relevance to arterial compliance, and the necessity to consult a doctor before taking the medication is emphasized.   Telmisartan / ARBs (main topic) Telmisartan — MedlinePlus drug info: https://medlineplus.gov/druginfo/meds/a601249.html Blood pressure meds overview (includes ARBs): https://medlineplus.gov/bloodpressuremedicines.html Key mechanisms mentioned PPARγ (PPARG) — NCBI Gene: https://www.ncbi.nlm.nih.gov/gene/5468 Endothelium + nitric oxide (NO) — NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK534266/ Angiotensin / aldosterone / "fight-or-flight" Aldosterone test — MedlinePlus lab test: https://medlineplus.gov/lab-tests/aldosterone-test/ Sympathetic nervous system ("fight-or-flight") — Cleveland Clinic explainer: https://my.clevelandclinic.org/health/body/23262-sympathetic-nervous-system-sns-fight-or-flight Lab tests mentioned in the episode Fasting insulin ("Insulin in Blood") — MedlinePlus lab test: https://medlineplus.gov/lab-tests/insulin-in-blood/ Hemoglobin A1C (HbA1c) — MedlinePlus lab test: https://medlineplus.gov/lab-tests/hemoglobin-a1c-hba1c-test/ C-reactive protein (CRP) — MedlinePlus lab test: https://medlineplus.gov/lab-tests/c-reactive-protein-crp-test/ Arterial stiffness / pulse pressure (longevity framing) Pulse pressure & arterial stiffness as risk predictors — PubMed: https://pubmed.ncbi.nlm.nih.gov/11224702/ Visceral fat resource mentioned Dr. Sean O'Mara website: https://drseanomara.com/   Show Notes   00:00 Welcome to the Hart2Heart Podcast. 01:22 Understanding Angiotensin and Its Effects 02:14 How ARBs Work and Their Benefits 03:00 Unique Properties of Telmisartan 03:36 Comparing Telmisartan with Other ARBs 04:44 Telmisartan's Impact on Endurance and Fat Loss 05:59 Telmisartan and Cardiovascular Health 09:57 Blood Pressure Basics and Pulse Pressure 18:54 Telmisartan's Role in Longevity and Dosing 27:28 Conclusion and Final Thoughts   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

It's been three full years since the Ohio state government decided to detonate derailed train cars containing vinyl chloride in the village of East Palestine.You might remember the apocalyptic imagery that came out of that explosion—it looked like a nuclear bomb had gone off.Three years later, anecdotal evidence is showing that the residents are experiencing thyroid disease, cancers, respiratory problems, neurological issues, asthma, and other problems.The National Institutes of Health (NIH) has now announced a $10 million research project to study the long-term health effects on the people living there.Let's review what took place there in 2023, what the effects appear to be now, as well as what the NIH is doing about it.

It's In the News.. a look at the top headlines and stories in the diabetes community. This week's top stories: T1D in the Olympics & Superbowl, Trump RX goes live, Ozempic pill available soon, tech updates from Medtronic, Beta Bionics, Eversense 365 and more! Announcing Community Commericals! Learn how to get your message on the show here. Learn more about studies and research at Thrivable here Please visit our Sponsors & Partners - they help make the show possible! Omnipod - Simplify Life All about Dexcom  T1D Screening info All about VIVI Cap to protect your insulin from extreme temperatures The best way to keep up with Stacey and the show is by signing up for our weekly newsletter: Sign up for our newsletter here Here's where to find us: Facebook (Group) Facebook (Page) Instagram Check out Stacey's books! Learn more about everything at our home page www.diabetes-connections.com  Episode transcription with links: Welcome! I'm your host Stacey Simms and this is an In The News episode.. where we bringing you the top diabetes stories and headlines happening now. A reminder that you can find the sources and links and a transcript and more info for every story mentioned here in the show notes. Quick reminder: We are just over one week from our first Moms' Night Out event of the year. While the plans are all set – the speakers, the vendors, the raffles and the fun is ready to go, it's always amazing how many people hear of these event last minute. That's fine, they're welcome! But if you're thinking of attending a future event – registration is open for We're going to Nashville next March 6-7 and Detroit in September – no need to wait. And we've got Club 1921 events for health care professionals and patient leaders in 6 cities this year! All the info is over at diabetes-connetionss.com events/   Okay.. our top story this week: XX Gotta be a quick shout out to some incredible T1D athletes – we had TWO in the super bowl this past weekend – Chad Muma of the New England Patriots and Logan Brown of the Seattle Seahawks AND there are at least two athletes with type 1 competing at the Winter Olympics. Hannah Schmidt competes in ski cross for Canada – she was diagnosed with Type 1 diabetes at age 12 years old.  Anna FarnSchadt Fernstäd a Czech skeleton racer diagnosed in 2022 after she'd already been to several Olympics. We wish them all the best!   https://english.radio.cz/skeleton-racer-anna-fernstadtova-overcoming-adversity-headfirst-down-ice-8876699 XX The government website TrumpRx.gov is live..  the website does not sell prescription drugs. Instead, it allows people to look up their drugs and then navigate to buy them elsewhere, either from a major drug company or a pharmacy. The 43 drugs listed on the site have prices ranging from $3 to over $5,500. TrumpRx does include warnings that the site may not be the best option to save money on prescriptions. Each product page advises: "If you have insurance, check your co-pay first — it may be even lower." For now, the website says its prices are for people paying with their own money, rather than going through insurance. The only insulin listed right now is Lilly's insulin lispro – and it's the same price as you'd find through Illy's insulin value program. I looked up diabetes meds.. For example, if you have an insurance co-pay of $25 a month for Farxiga, a drug often used for diabetes, you would be paying $182 on TrumpRx. As you can imagine, though ,this is complicated and as with most of our healthcare system, it may be good in some cases and not much help in other.  I'd suggest calling your local pharmacist or checking with your human resource dept. https://www.nytimes.com/2026/02/06/health/trumprx-prescription-drug-prices-consumers.html XX Novo Nordisk will launch some doses of its oral semaglutide for diabetes under the brand name Ozempic pill in the second quarter of this year. The company said the U.S. Food and Drug Administration has approved Ozempic tablets in three different doses. Novo says The new Ozempic name is intended to help patients and health care professionals more easily recognize the available treatment options for type 2 diabetes Semaglutide tablets have been available under the brand name Rybelsus Ruh BELL sis for diabetes since 2019 but with different dosing. The pill is also approved to reduce the risk of certain cardiovascular conditions in adults with type 2 diabetes who are at high risk for these events. The FDA had approved the new doses based on a bioequivalence study and the clinical trial data for Rybelsus, Novo said. https://www.reuters.com/business/healthcare-pharmaceuticals/novo-launch-ozempic-pill-diabetes-second-quarter-this-year-2026-02-04/ XX https://www.contemporarypediatrics.com/view/early-screening-for-type-1-diabetes-found-effective-in-children XX Possible new way to identify and track the progress of type 1 diabetes before clinical onset. A recent study published in Science Advances described the application of subcutaneous microporous scaffolds. These are inserted and have been shown to  identify changes in cancer, multiple sclerosis, and T1D by capturing changes of immune cells over the course of a disease. This is a proof of concept study in mice.. so very early days. https://www.news-medical.net/news/20260204/Implantable-immune-scaffold-predicts-type-1-diabetes-weeks-before-symptoms.aspx XX A large global genetics study shows that many key drivers of Type 2 diabetes operate outside the bloodstream. In a major international project led in part by the University of Massachusetts Amherst and Helmholtz Munich in Germany, researchers linked hundreds of genes and proteins to the disease. The work, published in Nature Metabolism, points to a key challenge in diabetes research: the biology behind rising blood sugar does not play out the same way in every part of the body. It also shows why including people from many backgrounds matters, since genetic clues that stand out in one population may be faint or invisible in another. Huge study, 2.5 million people worldwide comparing patterns across seven tissues tied to diabetes and four global ancestry groups, then asked a simple question: what do you miss if you only measure blood? Across the seven tissues, the researchers found causal evidence pointing to 676 genes. Yet overlap with blood was limited: only 18% of genes with a causal effect in a primary diabetes tissue, such as the pancreas, showed a matching signal in blood. At the same time, 85% of genetic effects observed in diabetes-relevant tissues were completely absent from blood-based analyses. The findings lay out a roadmap for future research aimed at understanding the biological pathways underlying Type 2 diabetes and developing more effective treatments. https://scitechdaily.com/massive-global-study-rewrites-the-biology-of-type-2-diabetes/ XX Express Scripts settled the U.S. Federal Trade Commission's claims its insulin pricing practices violated antitrust and consumer protection laws, and agreed to changes aimed at lowering costs for patients, insurers and small pharmacies The settlement, first reported by Reuters, fits with that goal, and allows the FTC to pare down a case brought by the former Biden administration against Cigna's Express Scripts, UnitedHealth Group Inc's (UNH.N), Optum unit and CVS Health Corp's (CVS.N), CVS Caremark. The case against Optum and Caremark is ongoing. Pharmacy benefit managers, which set how drugs are covered by health insurance, have faced a decade of scrutiny from regulators and lawmakers over pricing practices. While the industry has already made reforms, the settlement gives the FTC power to enforce broader changes at Express Scripts. The 10-year agreement restricts Express Scripts' ability to engage in practices critics say contribute to high costs, like pocketing rebate payments from drugmakers based on the list price of drugs. The FTC estimates the agreement could save patients as much as $7 billion over a decade. https://www.reuters.com/world/cigna-settles-ftc-insulin-case-commits-overhauling-drug-pricing-2026-02-04/ XX Audio? Congress has passed bipartisan legislation to extend and strengthen the Special Diabetes Program (SDP), a cornerstone of Federal investment in type 1 diabetes (T1D) research. The President signed the legislation and it is now law. Extends the SDP through December 31, 2026, and increases funding from $160 million to $200 million annually. Strengthens overall funding for the National Institutes of Health (NIH) by $415 million. Increases diabetes research funding at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) by $10 million. Created by Congress and administered by the NIH, the SDP has contributed nearly $3.6 billion to T1D research and has played a role in nearly every major breakthrough in the field. A recent study conducted by Avalere Health shows that of the nearly 3.6 billion invested into the SDP by Congress since the establishment of the program, the Federal Government has realized $50 billion in healthcare savings through improved health outcomes from the use of SDP driven therapies and devices https://www.breakthrought1d.org/news-and-updates/congress-passes-bipartisan-extension-of-the-special-diabetes-program-securing-critical-t1d-research-funding/ XX Dexcom is rolling out what they're calling AI-enabled enhancements to Stelo, further transforming how users track and understand their glucose health. Expanded Smart Food Logging including a comprehensive nutrition database of more than 1M meals that provides a breakdown of calories, carbohydrates, protein, fat, dietary fibers, and more. More ways to meal track including text search, barcode scanning or taking a photo of the meal, creating a seamless and intuitive meal tracking solution. A redesigned Daily Insights feature which will introduce a new interface with more personalized recommendations. The newest features will launch nationwide in the coming weeks.  XX Beta Bionics has received a warning letter from the Food and Drug Administration following an inspection last year, the company disclosed on Friday. The diabetes technology company said in a securities filing that the warning letter concerns non-conformities with the company's quality management system, medical device reporting, and correction and removals. The warning letter has not yet been posted by the FDA.   The company said in the filing that it has already taken actions to improve the processes described in the warning letter, and it is working on a written response to the FDA.   The firm does not expect the warning letter to affect the planned launch of a new insulin patch pump by the end of 2027. Beta Bionics unveiled a prototype of the device, called Mint, last year at the American Diabetes Association's Scientific Sessions. The company also does not expect the warning letter to affect its financial results. https://www.medtechdive.com/news/beta-bionics-receives-fda-warning-letter/811140/?utm_source=Sailthru&utm_medium=email&utm_campaign=Issue%3A+2026-02-04+MedTech+Dive+%5Bissue%3A81423%5D&utm_term=MedTech+Dive&fbclid=IwY2xjawPwhDZleHRuA2FlbQIxMABicmlkETFaUUcyYmNQWldjZ2xudElic3J0YwZhcHBfaWQQMjIyMDM5MTc4ODIwMDg5MgABHouF8M3IstTyslPRgeHWUWVVdOAGOtzPWt_yNFcj9eYruqSPz3e86Iwcbpt8_aem_7q4D97vJVjHKfEwvoyUpgw XX Sequel Med Tech is reviewing co-founder Dean Kamen's ties to Jeffrey Epstein after recently released documents revealed new details about the longstanding relationship between the two men. The documents show that Kamen visited Epstein's island, and remained in contact with him for years after Epstein was convicted of sex crimes involving minors. Kamen has not been accused of any wrongdoing. In a statement, Sequel Med Tech said the Manchester-based company is aware of the documents pertaining to Kamen and – quote - "Sequel's Board of Directors has unanimously decided to engage an external law firm to review these disclosures and provide recommendations aligned with our mission to serve people living with diabetes," Kamen has not issued a statement regarding his reported connection to Epstein.   https://www.bostonglobe.com/2026/02/04/metro/nh-dean-kamen-jeffrey-epstein-review/ https://www.bostonglobe.com/2026/02/04/metro/nh-dean-kamen-jeffrey-epstein-review/ https://www.nbcboston.com/news/local/nh-inventor-placed-on-leave-after-epstein-messages-surface-report-says/3888569/ XX Abbot reports 860 serious injuries linked to the recall of some of its glucose monitoring sensors. We told you about this recall late last year, these numbers are an FDA update.     Abbott said the sensors can provide incorrect glucose readings over extended periods, which could lead to users making dangerous treatment decisions, including eating excessive carbohydrates along with skipping or delaying insulin doses, potentially leading to serious health risks. The company said it has identified and resolved the cause of the issue, which relates to one production line among several that make Libre 3 and Libre 3 Plus sensors.   https://www.reuters.com/business/healthcare-pharmaceuticals/abbott-recalls-glucose-sensors-after-seven-deaths-linked-faulty-readings-2026-02-04/ XX Updates from Medtronic & Senseonics – and a first from Nick Jonas.. right after this..   I'm excited to share that the FDA has cleared the MiniMed 780G system with the Instinct sensor, made by Abbott, for people with type 2 diabetes.  Medicare has also now approved coverage for the Instinct sensor for use with the MiniMed 780G system. This clearance and expanded coverage mean more people will have access to pairing our most advanced automated insulin delivery technology with the Instinct sensor, that offers a smaller, 15-day sensor experience.  They're also launching the MiniMed 780G system Pump Evaluation Program.  This program gives individuals living with diabetes the ability to try the full MiniMed 780G system at no cost for 30 days.† This includes the pump, the sensor of their choice, one month of infusion sets and reservoirs, everything but the insulin. They'll contact your doctor for you to get a prescription and get the process rolling. https://www.medtronicdiabetes.com/pump-evaluation-program XX Senseonics announced today that its Eversense 365 continuous glucose monitor (CGM) system received CE mark approval – that's European clearance.  This comes on the heels of the launch of Eversense 365 with Sequel Med Tech's twiist pump, marking the first pump integration for the CGM. Senseonics plans to launch Eversense 365 in Germany, Italy, Spain and Sweden in the coming months. Meanwhile, Senseonics continues to work toward an FDA investigational device exemption (IDE) submission for its next-generation Gemini transmitter-less CGM by the end of this year. https://www.drugdeliverybusiness.com/senseonics-ce-mark-eversense-365-cgm/ XX A huge shout out to Dr. Emily Blum, who just accomplished riding 100 miles in Antarctica for Breakthrough T1D! Despite having no direct connection to Type 1 Diabetes, Emily has been riding and fundraising for BreakthroughT1D for 10 years now. She is an integral part of the Georgia Ride team, training and riding many miles, and most importantly has raised tens of thousands of dollars to support the cause of ridding the world of T1D. She is surgeon and deeply involved with medical innovation, with an incredibly busy schedule, but jumped at the chance to take on the challenge of riding a century on every continent. Having already completed North America, Europe, Australia, Asia, and now Antarctica, only Africa and South America remain. Emily rides on and continues to be an inspiration to everyone who meets her. XX   https://diabetes-connections.com/t1d-connection-and-people-magazine-elise-zach-share-their-story/ XX Nick Jonas's becomes the first artist ever to wear a CGM on an album cover - new upcoming solo album Sunday Best, releasing Feb. 6.  The release says: This marks a powerful step forward in normalizing diabetes and raising awareness for the condition on a global scale. This moment adds to the growing visibility of diabetes in pop culture, alongside milestones like a Type 1 diabetes Barbie and Pixar characters wearing diabetes technology.

Read "ME/CFS and Long COVID share similar symptoms and biological abnormalities: road map to the literature" – co-authored by Dr. Anthony L. Komaroff & W. Ian Lipkin. https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1187163/full    Fatigue is the body's hard-wired response to a viral infection. In today's episode, Haylie Pomroy shares insights with Dr. Anthony L. Komaroff to examine the history of ME/CFS research, the causes and triggers of ME/CFS and other post-infectious chronic illnesses, and the abnormalities observed in the brain and autonomic nervous system among patients with ME/CFS and long COVID. Dr. Komaroff also addresses how patients have often been dismissed within the healthcare system, explains the physical and psychological processes involved in these conditions, and discusses how he and other clinicians are now moving to the forefront of diagnosis and treatment.   Register for the Integrative Medicine Luncheon featuring Dr. Payam Hakimi on  February 14, 2026. https://nova.zoom.us/meeting/register/RQnykYIKRZO-yVykmDp-YQ#/registration   Dr. Anthony L. Komaroff is a distinguished Professor of Medicine at Harvard Medical School and a Senior Physician at Brigham and Women's Hospital. He has held significant leadership roles, including Director of the Division of General Medicine and Primary Care at Brigham and Women's Hospital. Dr. Komaroff is known for his research on myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and human herpesvirus infections. He has published over 270 research articles and book chapters and served on numerous advisory committees for major health organizations.   LinkedIn: https://www.linkedin.com/in/anthony-l-komaroff-64133346/  Facebook: https://web.facebook.com/anthonyl.komaroff    Solve ME: https://solvecfs.org  Open Medicine Foundation: https://www.omf.ngo  National Institutes of Health (NIH): https://www.nih.gov/mecfs/about-mecfs  Centers for Disease Control and Prevention (CDC): https://www.cdc.gov/me-cfs/about/index.html   Haylie Pomroy, Founder and CEO of The Haylie Pomroy Group, is a leading health strategist specializing in metabolism, weight loss, and integrative wellness. With over 25 years of experience, she has worked with top medical institutions and high-profile clients, developing targeted programs and supplements rooted in the "Food is Medicine" philosophy. Inspired by her own autoimmune journey, she combines expertise in nutrition, biochemistry, and patient advocacy to help others reclaim their health. She is a New York Times bestselling author of The Fast Metabolism Diet.   Learn more about Haylie Pomroy's approach to wellness through her website: https://hayliepomroy.com   Instagram: https://www.instagram.com/hayliepomroy  Facebook: https://www.facebook.com/hayliepomroy  YouTube: https://www.youtube.com/@hayliepomroy/videos  LinkedIn: https://www.linkedin.com/in/hayliepomroy/  X: https://x.com/hayliepomroy    Enjoy our show? Please leave us a 5-star review so we can bring hope and help to others. You can also watch the show on our YouTube.https://www.youtube.com/@NSU_INIM   Sign up today for our newsletter. https://nova.us4.list-manage.com/subscribe?u=419072c88a85f355f15ab1257&id=5e03a4de7d    This podcast is brought to you by the Institute for Neuro-Immune Medicine. Learn more about us here.   Website: https://www.nova.edu/nim/ Facebook: https://www.facebook.com/InstituteForNeuroImmuneMedicine Instagram: https://www.instagram.com/NSU_INIM/ Twitter: https://www.twitter.com/NSU_INIM

In this podcast episode, the speaker shares his personal journey of quitting THC, explaining his reasons, the gradual process over several years, and the impacts on his life. He recounts his history with THC, from early recreational use to daily dependence for sleep aid during medical school and residency. The speaker emphasizes that he does not oppose cannabis, recognizing its medicinal value, but wanted to overcome his dependency. He details his method of reducing THC use through vaping and CBD alternatives, ultimately leading to his last use in January 2025. Alongside his personal story, he discusses the benefits and potential negative impacts of THC and other cannabinoids, offering insights into who might consider quitting and why.   Cannabis, THC & Quitting Cannabis (Marijuana) — NIDA overview: https://nida.nih.gov/research-topics/cannabis-marijuana Cannabis Use Disorder — NCBI Bookshelf (StatPearls): https://www.ncbi.nlm.nih.gov/books/NBK538131/   Sleep, REM & Withdrawal Cannabis and sleep architecture — systematic review (PubMed): https://pubmed.ncbi.nlm.nih.gov/40967124/ Effects of cannabinoids on sleep — review (PMC): https://pmc.ncbi.nlm.nih.gov/articles/PMC8116407/   Non-Intoxicating Cannabinoids Mentioned CBD + anxiety — systematic review (PMC): https://pmc.ncbi.nlm.nih.gov/articles/PMC11595441/   CBG — acute effects + cognition (PMC): https://pmc.ncbi.nlm.nih.gov/articles/PMC11246434/ THCV — overview/commentary (PubMed): https://pubmed.ncbi.nlm.nih.gov/33526143/ CBC — therapeutic potential review (PMC): https://pmc.ncbi.nlm.nih.gov/articles/PMC11493452/   Potency: Concentrates Marijuana Concentrates — NIDA DrugFacts PDF: https://nida.nih.gov/sites/default/files/df-marijuana-concentrates.pdf   Supplements Mentioned Omega-3 Fatty Acids — NIH ODS (Consumer): https://ods.od.nih.gov/factsheets/Omega3FattyAcids-Consumer/ Vitamin D — NIH ODS (Consumer): https://ods.od.nih.gov/factsheets/VitaminD-Consumer/   Show Notes 00:00 Introduction: Why I Quit THC 02:18 My History with THC 06:10 Transition to Medical Use 13:53 The Quitting Process 20:11 Benefits and Challenges of Quitting 25:07 Thoughts on THC and Other Cannabinoids 33:25 Conclusion and Final Thoughts   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart  

In this episode of the Vital Health Podcast, host Duane Schulthess examines how NIH-funded research fits into the U.S. innovation and IP ecosystem, and why today’s political rhetoric about “government-developed drugs” often misses how commercialization actually happens. Featuring expert perspectives on NIH technology transfer and drug IP from: Mark Rohrbaugh: Former Director of Technology Transfer and Innovation Policy at the National Institutes of Health (NIH), IP Consultant at Vital Transformation Gwen O’Loughlin: Research Partner at Vital Transformation They discuss how the Bayh-Dole Act shaped university tech transfer, what government interest statements do - and do not - tell you about a drug’s origins, why “march-in rights” were designed as a development backstop rather than a pricing tool, and how proposals to redirect royalties or restrict NIH-industry collaboration could disrupt the pipeline that turns early science into real-world therapies. Key Topics: NIH’s Role in the Innovation Pipeline: How NIH funding de-risks foundational science, how industry and universities translate it, and why “NIH developed all drugs” is a misleading simplification. Government Interest Statements: What the statement signals, why it is inconsistently surfaced across patents, and what large-scale reviews suggest about how often it appears in drug-related patent portfolios. March-In Rights and Policy Misuse: The original purpose (anti-shelving and public health needs), how petitions are evaluated in practice, and why pricing-based efforts have not succeeded. Mechanisms Supporting Translation: Why CRADAs and licensing structures matter for bringing technologies to market and for enabling NIH research with proprietary industry tools. Forward Outlook: How royalty diversion or restricting partnerships could weaken incentives and capacity, and why the guests anticipate near-term disruption with longer-term consequences. Opinions expressed are those of the speakers.See omnystudio.com/listener for privacy information.

Most people think they go into your body and make all new tissue… but in actuality, they are a delivery mechanism of growth factors. I call them the ultimate traffic cop. In this episode, the host converses with Dr. Jesse Morse, a physician specializing in regenerative and anti-aging medicine. They delve into the intricacies of stem cells and their various sources, including bone marrow, fat, and donor tissue.  Dr. Morse highlights the role of exosomes and growth factors in the healing process. The discussion also focuses on the prevention and treatment of Achilles tendon tears, emphasizing the importance of blood supply, proper diagnosis, and innovative therapies. Additionally, they explore the benefits and applications of various peptides, including BPC 157, TB 500, and MotC, for enhancing healing, anti-aging, and overall health. Dr. Morse also addresses the significance of nutrition and detoxification in maintaining optimal health and preventing injuries. Dr. Jesse Morse is a Miami-based, double board-certified physician in Family and Sports Medicine who specializes in regenerative medicine, injury recovery, and longevity. Since shifting from traditional sports medicine in 2020, he has focused on non-surgical approaches to tendon and ligament injuries using therapies like PRP, stem-cell–based treatments, exosomes, and peptides, alongside functional and anti-aging strategies centered on mitochondrial health, immune support, toxin reduction, and personalized recovery—helping everyone from active adults to high-performance athletes restore function and prevent major injuries like Achilles tears while educating widely online. Connect with him on: Instagram: https://www.instagram.com/drjessemorse/ — Sports medicine, regenerative medicine & insights Linktree (aggregated links to socials & resources): https://linktr.ee/DrJesseMorse   Supplements, Compounds & Peptides Collagen (protein / connective tissue support): https://www.ncbi.nlm.nih.gov/books/NBK507922/ Vitamin C (collagen activation / antioxidant): https://ods.od.nih.gov/factsheets/VitaminC-HealthProfessional/ Creatine (muscle & mitochondrial support): https://ods.od.nih.gov/factsheets/Creatine-HealthProfessional/ BPC-157 (peptide – tendon & gut healing): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504390/ TB-500 / Thymosin Beta-4 (peptide – tissue repair): https://pubmed.ncbi.nlm.nih.gov/22674782/ GHK-Cu (copper peptide – skin, joints, stem-cell signaling): https://pubchem.ncbi.nlm.nih.gov/compound/GHK-Cu MOTS-c (mitochondrial peptide): https://pubmed.ncbi.nlm.nih.gov/25174616/ SS-31 / Elamipretide (mitochondrial peptide): https://pubmed.ncbi.nlm.nih.gov/29515116/ Thymosin Alpha-1 (immune modulation peptide): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8367996/ LL-37 (antimicrobial / immune peptide): https://pubmed.ncbi.nlm.nih.gov/15184378/ 5-Amino-1MQ (NNMT inhibitor / fat loss): https://pubchem.ncbi.nlm.nih.gov/compound/5-Amino-1MQ N-Acetylcysteine (NAC – liver & detox support): https://www.ncbi.nlm.nih.gov/books/NBK537183/ Glutathione (antioxidant / detox): https://ods.od.nih.gov/factsheets/Glutathione-HealthProfessional/ NAD⁺ / NMN / NR (mitochondrial & anti-aging support): NMN: https://pubchem.ncbi.nlm.nih.gov/compound/Nicotinamide-mononucleotide NR: https://pubchem.ncbi.nlm.nih.gov/compound/Nicotinamide-riboside Regenerative & Injection Therapies PRP – Platelet-Rich Plasma: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990861/ Bone Marrow–Derived Stem Cells (BMAC): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630382/ Adipose-Derived Stem Cells: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416130/ Amniotic / Placental Tissue Products: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124018/ Exosomes (cell signaling vesicles): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465611/ Ultrasound-Guided Injections: https://radiopaedia.org/articles/musculoskeletal-ultrasound-guided-injection Needle Tenotomy (scar-tissue disruption): https://pubmed.ncbi.nlm.nih.gov/30428129/ Detox, Blood & Environmental Interventions Sauna (heat detox & cardiovascular benefit): https://www.health.harvard.edu/staying-healthy/saunas-and-your-health Binders – Modified Citrus Pectin: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452227/ GI Detox / Toxin Binders (general concept): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654245/ Heavy Metal Chelation (DMPS concept): https://pubmed.ncbi.nlm.nih.gov/12198644/ Mercury Toxicity: https://www.cdc.gov/mercury/index.html Microplastics in Humans: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068600/ EBOO Therapy (ozone-based blood filtration): https://pubmed.ncbi.nlm.nih.gov/36681461/ Therapeutic Plasma Exchange (TPE): https://www.ncbi.nlm.nih.gov/books/NBK557561/ INUSpheresis (advanced plasma filtration): https://pubmed.ncbi.nlm.nih.gov/37324197/ Medications & Drug Classes Mentioned Corticosteroids (Prednisone – tendon risk): https://medlineplus.gov/druginfo/meds/a601102.html Fluoroquinolone Antibiotics (tendon rupture risk): https://www.fda.gov/drugs/drug-safety-and-availability/fda-updates-fluoroquinolone-antibiotics GLP-1 Agonists (Semaglutide / Tirzepatide / Retatrutide discussion): Semaglutide: https://pubmed.ncbi.nlm.nih.gov/36421543/ Tirzepatide: https://pubmed.ncbi.nlm.nih.gov/35220624/ Nutrition & Food-Related Mentions Protein Intake & Muscle Health: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566799/ American Gluten vs European Wheat: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8799814/ Seed Oils & Inflammation (discussion topic): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196963/ Dairy & Inflammation (contextual mention): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122229/ Key Mechanisms & Concepts Poor Blood Supply in Achilles Tendon (Watershed Zone): https://pubmed.ncbi.nlm.nih.gov/17021202/ Mitochondrial Dysfunction & Aging: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843959/ Stem Cells as "Medicinal Signaling Cells": https://pubmed.ncbi.nlm.nih.gov/25784997/   Show Notes 00:00 Introduction to Exosomes and Stem Cells 01:01 Dr. Morse's Background and Transition to Regenerative Medicine 02:03 Achilles Tendon Tears: Causes and Prevention 05:02 Preventative Measures and Treatments for Achilles Injuries 10:26 The Role of Nutrition in Tendon Health 12:53 Peptides and Their Impact on Tendon Health 15:50 Stem Cells: Misconceptions and Applications 20:52 Comparing Stem Cell Sources and Their Potency 29:52 The Controversy of International Stem Cell Treatments 34:04 Cleaning Toxins from Your Blood 34:19 The Toxic Burden in Our Environment 35:57 Practical Detox Methods 37:47 Mercury and Heavy Metal Testing 44:47 The Problem with American Gluten 46:49 Underrated Peptides for Health 53:42 Growth Hormone and Anti-Aging 01:03:34 Advanced Blood Cleaning Techniques 01:04:51 Conclusion and Contact Information   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

The mental health of the American president is critical to the future of the country–and it's clear to even a casual observer of Donald Trump that his patterns of speech, inability to state the truth on just about any subject, and the apparent joy he gets out of watching other people suffer–indicate that something strange is going on in the way he perceives the world.Psychiatrists are often reluctant to speculate diagnosing someone in the absence of a face-to-face clinical exam. And yet, it appears that Trump has taken several such exams–including brain scans and mental acuity tests–that he brags about, but never releases reports on. Which is why I have brought Frank George, Ph.D. onto the show today. George holds a PhD in Psychology and Neuroscience from the University of Colorado Boulder, and was formerly the Chief of Behavioral and Biochemical Genetics at the National Institutes of Health (NIH). He's an expert on narcissistic personality disorder and writes a popular substack that focuses on Trump's Mental state called “The Gaslight Report” which I highly recommend you take a look at.Get Early Access on Substackhttps://sgcarney.substack.com/Join this channel to get access to perks:https://www.youtube.com/channel/UC3PyxGKt94kLzVqkkjEgRFw/join

Most "detox" advice focuses on cleanses and quick fixes — but real detoxification is a constant, biological process your body runs every day. In this solo episode, the host breaks down how detoxification actually works, starting with what counts as a "toxin" (including hormones and environmental chemicals) and how the body packages them for elimination. You'll learn the key roles of the liver, kidneys, and gut — and why detox can succeed in the liver but fail in the intestines, especially when certain gut bacteria produce enzymes like β-glucuronidase that can send toxins back into circulation. The episode covers major detox pathways (including glucuronidation), the importance of bile flow and regular bowel movements, and why fiber is one of the biggest levers you can pull to support elimination. It also explores how hydration, electrolyte balance, stress, and overtraining can influence detox capacity, plus the limited-but-real role sweating may play in clearing certain heavy metals. Finally, you'll get practical strategies for supporting a healthier gut microbiome and reducing toxin buildup — from diet and polyphenols to commonly discussed supplements like NAC, glycine, and taurine.    Supplements & Compounds Magnesium (supplement/mineral): https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/ Zinc (supplement/mineral): https://ods.od.nih.gov/factsheets/Zinc-HealthProfessional/ Psyllium (fiber / bulk-forming laxative): https://medlineplus.gov/druginfo/meds/a601104.html Spirulina (supplement / "blue-green algae"): https://www.ncbi.nlm.nih.gov/books/NBK548312/ Activated Charcoal (binder / poisoning use): https://pmc.ncbi.nlm.nih.gov/articles/PMC6620762/ Glycine (amino acid): https://pubchem.ncbi.nlm.nih.gov/compound/Glycine N-Acetylcysteine (NAC): https://www.ncbi.nlm.nih.gov/books/NBK537183/ Foods / Gut & Microbiome Mentions Fermented foods (kimchi, sauerkraut, etc.): https://health.clevelandclinic.org/5-reasons-you-should-add-more-fermented-foods-to-your-diet-infographic Kimchi (specific fermented food mentioned): https://health.clevelandclinic.org/is-kimchi-good-for-you Sourdough (food example mentioned): https://en.wikipedia.org/wiki/Sourdough Berries (food example mentioned): https://en.wikipedia.org/wiki/Berry Wild rice (food example mentioned): https://en.wikipedia.org/wiki/Wild_rice Medications Mentioned Ibuprofen (Advil): https://medlineplus.gov/druginfo/meds/a682159.html Naproxen (NSAID): https://medlineplus.gov/druginfo/meds/a681029.html Lifestyle / Modalities Mentioned Sauna: https://www.health.harvard.edu/staying-healthy/saunas-and-your-health Infrared sauna: https://health.clevelandclinic.org/infrared-sauna-benefits Red light therapy (photobiomodulation): https://my.clevelandclinic.org/health/articles/22114-red-light-therapy Environmental / Exposure Topics Mentioned BPA (bisphenol A): https://www.niehs.nih.gov/health/topics/agents/sya-bpa Phthalates: https://wwwn.cdc.gov/tsp/substances/ToxChemicalListing.aspx?toxid=41 Lead exposure: https://www.cdc.gov/lead-prevention/prevention/index.html Arsenic in rice: https://www.fda.gov/food/environmental-contaminants-food/what-you-can-do-limit-exposure-arsenic Key Mechanism/Concept Mentioned Gut microbial β-glucuronidase (and "glucuronidation" talk): https://pmc.ncbi.nlm.nih.gov/articles/PMC9717552/   Show Notes 00:00 Introduction to Detoxification 02:00 Understanding Toxins and Hormones 05:36 Common Environmental Toxins 07:10 The Detoxification Process 10:52 Gut Health and Detoxification 20:07 Sweating and Detoxification 23:35 Supplements for Detoxification 29:31 Conclusion and Final Tips   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart  

Good morning from Pharma Daily: the podcast that brings you the most important developments in the pharmaceutical and biotech world. This morning, we're diving into a series of fascinating updates that underline the vibrant and ever-changing landscape of our industry.The J.P. Morgan Healthcare Conference recently set the stage for some intriguing discussions, particularly from Novo Nordisk. The company is diversifying its metabolic drug development portfolio by exploring innovative avenues, reflecting a broader industry trend where firms seek to balance their core expertise with novel therapeutic areas. This strategic diversification is crucial as companies aim to address complex health issues with an expansive approach to innovation. Novo Nordisk's leadership emphasized this strategic pivot towards diversifying their innovation pipeline beyond traditional metabolic disorders, aiming to keep the company at the forefront of pharmaceutical advancements.Meanwhile, Takeda's R&D head, Andy Plump, brought attention to some challenges currently facing U.S. innovation. Despite a sluggish start at the conference, recent months have been buzzing with significant deal-making activities. This scenario highlights the delicate dance between maintaining steady innovation and navigating regulatory hurdles and economic pressures. However, optimism remains high, with strategic investments and collaborations seen as potential catalysts for rejuvenation in research.Amgen made waves by presenting promising results from an exploratory study of Maritide in weight loss maintenance. The study's outcomes signal a significant milestone in obesity management and set the stage for further clinical trials and potential approval processes. This advancement offers hope in addressing what remains a critical public health issue worldwide.A significant development at the National Institutes of Health (NIH) is the leadership change as Dr. Gary Gibbons steps down as Director of the Heart, Lung, and Blood Institute. This shift adds to a growing list of interim leadership roles across NIH's 27 institutes and centers, which could impact continuity in critical research projects and funding initiatives.On the corporate front, Sonoma Pharmaceuticals announced notable workforce reductions due to financial challenges, while Lyra Therapeutics decided to abandon its rhinosinusitis treatment project alongside laying off its entire team. These decisions highlight the financial volatility that smaller biotech firms face amid competitive pressures and regulatory complexities. In contrast, Pretzel Therapeutics has emerged successfully from turbulent times, demonstrating resilience and adaptability within the biotech sector. Strategic restructuring and leadership realignment have positioned Pretzel Therapeutics for future growth in therapeutic development.A major highlight involves AbbVie entering into an agreement with the White House to reduce Medicaid drug prices while committing a substantial $100 billion investment in U.S. R&D over the next decade. This aligns with broader efforts to make healthcare more affordable while encouraging domestic pharmaceutical investment. AbbVie's substantial commitment towards U.S. R&D speaks volumes about their strategy within TrumpRx program contexts that aim at enhancing market penetration while balancing innovation investment against cost management pressures.Medtronic has expressed readiness to engage in mergers and acquisitions, indicating that medtech companies are poised for expansion through strategic buyouts. This move reflects an industry-wide capacity for growth through consolidation and collaboration. As we look towards mergers and acquisitions within medtech highlighted by Medtronic's intentions, it's clear that strategic M&A activities remain vital for companies seeking to expand capabilities and market presence in this competitive landscape.The FDA has aSupport the show

Medicine has transitioned due to massive tech adoption (Electronic Health Records EHRs, Artificial Intelligence AI, Telehealth), shifting patient expectations (consumerism, convenience), the rise of value-based care, new treatments (precision medicine), and increased focus on population health and prevention, all while grappling with rising costs, data security, and persistent access/equity gaps, making healthcare more data-driven, personalized, and digitally integrated but also more complex and fragmented.  We try to break it down to try and understand the changes and how they might improve the outcomes when going to the doctor.     Technological Revolution Electronic Health Records (EHRs) & Analytics: Widespread EHR adoption (95% of hospitals by 2017) streamlined data, enabling better analytics for management, diagnosis, and care coordination, notes HNI Healthcare and Becker's Hospital Review. Telehealth & Wearables: Virtual visits, health apps, and fitness trackers (like heart rate monitors) became common, improving access and remote monitoring, says ThriveAP. Artificial Intelligence (AI) & Machine Learning: AI now analyzes complex data for diagnostics, research, and clinical decisions, says Health Tech Academy and National Institutes of Health (NIH) | (.gov).  Evolving Patient & Provider Landscape Consumerism: Patients demand convenient, personalized care, challenging traditional models, notes Marathon Health and NEJM Catalyst Innovations in Care Delivery. New Care Models: Integration (ACOs, hospitalists) aimed at better quality/cost, but challenges in coordination persist, according to the National Institutes of Health (NIH) | (.gov). Population Health: Greater focus on prevention, chronic disease management (diabetes, obesity), and public health crises (COVID-19), says Health Data Management.  Shifting Medical Focus & Costs Precision Medicine: Tailored treatments using biomarkers are improving efficacy, notes faCellitate. Rising Costs: More expensive tech, drugs (like gene therapies), and increased demand contribute to significant spending increases, say National Institutes of Health (NIH) | (.gov) and Springer Publishing Company. Data & Billing Changes: The shift to complex coding (like ICD-10) improved data but added operational hurdles, say Becker's Hospital Review and National Institutes of Health (NIH) | (.gov) pmc.ncbi.nlm.nih.gov  . 

What if your "healthy" water intake is still quietly hurting your performance? In this solo episode, Dr. Mike breaks down hydration from a performance-first perspective — how dehydration affects cognition and physical output, why "8 glasses a day" is an oversimplified myth, and how to personalize your intake based on body size, activity level, diet, environment, and medications. He walks through practical guidelines (including 30–35 ml/kg/day), how to use urine + thirst cues without overcomplicating it, and why timing matters (especially around workouts, sauna use, and sleep). A major focus of this episode is electrolytes — what they do, how sweat changes your needs, and why sodium is often the key limiter for athletes, sauna users, and people eating low-carb/keto. Dr. Mike also covers potassium and magnesium, caffeine and hydration, the risks of overhydration, and the classic warning signs of hyponatremia. This is a comprehensive, no-BS guide to staying hydrated, replenishing electrolytes correctly, and improving energy, performance, and sleep.    Resources: Electrolyte & Hydration Products LMNT Official Home Page: https://drinklmnt.com/ LMNT Recharge Electrolyte Drink Mix: https://drinklmnt.com/products/lmnt-recharge-electrolyte-drink LMNT Variety Pack: https://drinklmnt.com/products/lmnt-recharge-variety-pack DIY Homemade Electrolyte Drink (LMNT Science): https://science.drinklmnt.com/electrolytes/best-homemade-electrolyte-drink-for-dehydration Gatorade Electrolyte Powder for Hydration (Official): https://www.gatorade.com/powders   Medical / Health Conditions & Guidance Hyponatremia — Symptoms & Causes (Mayo Clinic): https://www.mayoclinic.org/diseases-conditions/hyponatremia/symptoms-causes/syc-20373711 Hyponatremia — Diagnosis & Treatment (Mayo Clinic): https://www.mayoclinic.org/diseases-conditions/hyponatremia/diagnosis-treatment/drc-20373715   Lab Tests Magnesium, RBC (Labcorp): https://www.labcorp.com/tests/080283/magnesium-rbc   Mineral / Supplement References Magnesium — Fact Sheet for Health Professionals (NIH ODS): https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/ Potassium — Fact Sheet for Health Professionals (NIH ODS): https://ods.od.nih.gov/factsheets/Potassium-HealthProfessional/ Dietary Supplements for Exercise and Athletic Performance — Fact Sheet for Health Professionals (NIH ODS): https://ods.od.nih.gov/factsheets/ExerciseAndAthleticPerformance-HealthProfessional/   People / Sources Mentioned Robb Wolf (LMNT Science author page): https://science.drinklmnt.com/authors/robb-wolf Robb Wolf (official site): https://robbwolf.com/ Huberman Lab (official site): https://www.hubermanlab.com       Show Notes 00:00 Welcome Back to the Hart2Heart Podcast! 00:55 The Importance of Hydration 01:46 Daily Water Intake Guidelines 04:16 Sweat and Electrolyte Loss 06:56 Sodium: The Key Electrolyte 12:22 Potassium: Essential for Muscle and Heart Health 15:20 Magnesium: The Multi-Functional Mineral 20:08 Other Important Nutrients 22:33 Hydration Strategies and Special Populations 26:37 Final Tips and Conclusion   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

In this solo episode, Dr. Mike discusses the common issue of nocturia, where individuals frequently wake up at night to urinate, which disrupts sleep. The episode covers the root causes including sleep apnea, enlarged prostate, and overactive bladder, and dives into the roles of antidiuretic hormone (ADH) and atrial natriuretic peptide (ANP). It provides a comprehensive guide on addressing nocturia through behavioral modifications such as fluid restriction and sleep hygiene, supplements like pumpkin seed extract and beta-sitosterol, and pharmaceuticals including Desmopressin and alpha-blockers. The host also touches on treating sleep apnea with CPAP machines and mandibular advancement devices, emphasizing the importance of targeting the root cause for effective treatment.   Links: CPAP (Continuous Positive Airway Pressure) Beta-Sitosterol Desmopressin (Synthetic ADH) Show Notes: 00:00 Understanding nocturia and its connection to sleep apnea 01:00 Introduction and episode overview 02:00 Defining nocturia and its impact on sleep 03:00 Types of nocturia and their causes 04:30 The role of hormones in nocturia 05:30 Sleep apnea and its effects on nocturia 15:30 Behavioral modifications to reduce nocturia 24:00 Supplements for managing nocturia 30:00 Pharmaceutical solutions for nocturia   — The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to  cutting through the noise and uncovering the most effective strategies for optimizing health,  longevity, and peak performance. This podcast dives deep into evidence-based approaches to  hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise  protocols, leveraging sunlight light, and de-prescribing pharmaceuticals—using medications only when absolutely necessary.   Beyond health science, we tackle the intersection of public health and politics, exposing how  policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.   Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).   If you're ready to take control of your health and performance, this is the podcast for you. We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect on social with Dr. Mike Hart: Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart  

In this solo episode, Dr. Mike delves into the complex relationship between dopamine, romantic relationships, and the Coolidge Effect. The discussion highlights why men often feel the need for a new partner due to a desensitization of dopamine and how our overstimulated lifestyles contribute to this issue. The host explores the impact of modern habits on dopamine levels, the importance of boredom for resetting dopamine sensitivity, and the role of anticipation in maintaining desire. Practical solutions like dopamine resets, engaging in effort-based activities, and ensuring personal growth and solitude are discussed as ways to improve both individual well-being and relationship satisfaction. Links: The Dopamine Collapse Hypothesis: Foundations of Macro-Neuroeconomics   Show Notes: 00:00 Welcome back to the Hart2Heart Podcast with Dr. Mike Hart 01:30 Understanding the dopamine cycle 03:30 Daily habits and dopamine desensitization 09:00 The Coolidge effect and relationship dynamics 15:00 Dopamine resets and effort-based activities 22:00 Reviving desire in long-term relationships 28:38 "Our nervous system never gets any time to recover—and that kills desire."   — The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to  cutting through the noise and uncovering the most effective strategies for optimizing health,  longevity, and peak performance. This podcast dives deep into evidence-based approaches to  hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise  protocols, leveraging sunlight light, and de-prescribing pharmaceuticals—using medications only when absolutely necessary.   Beyond health science, we tackle the intersection of public health and politics, exposing how  policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.   Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).   If you're ready to take control of your health and performance, this is the podcast for you. We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect on social with Dr. Mike Hart: Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart  

So many unmet needs - so many opportunities for meaningful solutions. Given the number of potentially game-changing start-ups in the FemTech & Women's Health spaces, we need to support these startups the best we can. That's exactly what this week's guest, Theresa Neil, does as Founder & CEO of Femovate - the largest global design program for early-stage FemTech startups. Hear why FemTech startups can benefit from design & research support and how we can meet women's health needs today. Learn how Femovate selects the startups it partners with, the insights Theresa is gleaning working across sectors, and some of the most exciting innovations in the women's healthcare space today. Tune in to this episode to support the next great women's health innovations.   Learn more: Femovate Femovate LinkedIn Theresa Neil   Today's Hot Flash and other stats from: National Institutes of Health (NIH)

Do the many clinical trials into high-dose vitamin C prove it can actually treat the common cold and cancer, rather than just boost the immune system? Why is there ongoing scepticism? Why are multifactorial chronic diseases so hard to study in clinical trials? What is the right dosage to get the best results from vitamin C?In this episode we have the often misunderstood topic of Vitamin C as an antioxidant to get clear on, particular the high-dose approach and particularly delivered intravenously. Despite a very clear consensus that Vitamin C is a great booster to immune function, research that shows that it helps fight the common cold or flu have been dismissed by doctors and medical researchers; as well as claims that higher doses can increase its efficacy. Other claims that Vitamin C can help fight cardio-vascular disease and even cancer have been with even greater scepticism. So what exactly can vitamin C do to assist our immune function to fight disease, and why is there so much confusion about the answer given the high quantity of clinical trials data?Fortunately today's guest has exactly the right skill set and research knowledge to separate the science from the here-say, medical doctor and orthomolecular medicine researcher, Dr. Richard Z Cheng. Dr. Cheng has a PhD in biochemistry and molecular biology; he's served as a doctor in the US military; he has consulted for the National Cancer Institute, and presented at the National Institute of Health (NIH); he has conducted clinical trials; He is the editor in Chief of the Orthmolecular Medicine New Service; He is also a fellow of the American Academy of Anti- Aging medicine; and has run anti-aging and regenerative medicine clinics in both China and the US for over 20 years.What we discuss:00:00 Intro05:15 Most animals produce Vitamin C in the body, but not primates.06:00 Oxidation & Redox: Giving or receiving an electron.11:00 After reducing oxidation the body recycles it back into vitamin C.14:00 Teamwork: sharing electrons between nutrients and vitamins.18:20 Conventional consensus: good for prevention but not treatment.21:00 Over 80K papers on Vit C on Pub Med!21:30 Linus Pauling Intravenous Vitamin C for cancer and heart disease.27:00 Shortening of common cold and lowering of symptoms - Harri Hemila.29:00 Low dose studies dilute the data on the efficacy of the high dose studies.31:00 Intravenous treatment allows much higher doses safely.33:00 Differences in absorption between IV and oral application.35:20 Pro-oxidant effect only possible at IV high dose.36:30 IV clinical trials.39:20 Cytokine storm cascades in acute respiratory distress.44:00 High Dose IV Vitamin C saved lives in China during Covid 19.50:00 Attacks following Richard's NIH presentation on Vitamin C during covid.57:00 Cardio vascular disease - Vit. C research history.01:01:00 Collagen Synthesis for vascular walls & Vitamin C deficiency.01:07:20 Is the taboo for life style medicine lifting?01:09:30 Issues of gold standard RCT trials not working for multifactorial integrative interventions.01:16:00 Recommendations for preventative use of Vitamin C for listeners. References:E Cameron & Linus Pauling - 'Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer', 1976E.T. Creagan, 'Failure of high-dose vitamin C (ascorbic acid) therapy to benefit patients with advanced cancer', 1979Harri Hemilä - over 200 meta-analyses and clinical trialsPing Chen et al. 'Pharmacokinetic Evaluation of Intravenous Vitamin C'Richard Z Cheng, ‘Can early and high intravenous dose of vitamin C prevent and treat coronavirus disease 2019 (COVID-19)?'KU Cancer Center researchers announce study of high-dose intravenous vitamin C to treat muscle-invasive bladder cancer, 2024National Cancer Institute overview of IV Vitamin C cancer research.

Want to share your feedback? Send us a message!Dr. Shahriar SheikhBahaei, Assistant Professor of Neurobiology and Behavior at Stony Brook University, joins host Sara MacIntyre, M.A., CCC-SLP, to discuss emerging research exploring the cellular and neurobiological mechanisms underlying stuttering. Dr. SheikhBahaei shares his journey from lived experience with stuttering to leading a neuroscience research lab investigating how glial cells, particularly astrocytes, contribute to motor control and speech-related circuits.The conversation delves into several recent studies from his lab that utilize mouse models to uncover how alterations in astrocyte function and iron regulation may relate to the neural pathways involved in stuttering. Dr. SheikhBahaei walks listeners through the background, scientific rationale, and key findings of these studies, highlighting what they reveal about the non-vocal motor aspects of stuttering and how this basic science may inform future directions in understanding and treatment.The episode concludes with reflections on bridging laboratory research with the lived experiences of people who stutter and fostering collaboration among scientists, clinicians, and the stuttering community.Resources discussed:SheikhBahaei, S., et al. (2025). Non-vocal motor deficits in a transgenic mouse model linked to stuttering disorders. bioRxiv. https://www.biorxiv.org/content/10.1101/2025.08.08.669441v2SheikhBahaei, S., et al. (2025). Iron dysregulation in mice engineered with a mutation associated with stuttering. bioRxiv. https://www.biorxiv.org/content/10.1101/2025.07.30.667752v1SheikhBahaei, S., et al. (2024). Scientists, society, and stuttering: A multi-stakeholder approach. International Journal of Clinical Practice. https://onlinelibrary.wiley.com/doi/full/10.1111/ijcp.13678Shahriar SheikhBahaei, Ph.D., is a neuroscientist and faculty member at Stony Brook University. His research focuses on how the brain controls complex motor behaviors such as speech and breathing, particularly focusing on the role of astrocytes in neural circuits. Growing up with stuttering has influenced his lifelong pursuit to understand the neurobiology of speech and communication. He completed his Ph.D. in Neuroscience through a joint program at University College London and the National Institutes of Health (NIH). He later became one of the first Independent Research Scholars at NIH, where he established his own lab. At Stony Brook University, he continues to investigate the cellular and circuit foundations of speech disorders while also mentoring the next generation of scientists and advocating for more inclusive perspectives on communication.

Today on Sauna Talk, we are joined by the dynamic duo of researcher from Emery University, Deanna Kaplan and Roman Palitsky. Deanna Kaplan Deanna Kaplan, PhD is a clinical psychologist with expertise in digital health technologies. She has more than a decade of experience using wearable and smartphone-based technologies to study the dynamics of health processes and clinical change during daily life. Her research is grounded in a whole-person (bio-psycho-social-spiritual) model of health, and much of her work focuses on investigating the dynamics of change of integrative interventions, such as psychedelic-assisted therapies and contemplative practices. Dr. Kaplan is the Director of the Human Experience and Ambulatory Technologies (HEAT) Lab, a multidisciplinary collaboration between the Department of Family and Preventive Medicine and Emory Spiritual Health. More information about the HEAT Lab is here. Dr. Kaplan is the co-creator and Scientific Director of Fabla, an unlicensed Emory-hosted app for multimodal daily diary and ecological momentary assessment (EMA) research. Fabla is an EMA app that can securely collect voice-recorded, video-recorded , and photographic responses from research participants. More information about Fabla is here. Dr. Kaplan holds an adjunct appointment in Emory's Department of Psychology and is appointed faculty for several Emory centers, including the Winship Cancer Institute, Emory Spiritual Health (ESH), the Emory Center for Psychedelics and Spirituality (ECPS), and the Advancement of Diagnostics for a Just Society (ADJUST) Center. She also holds an appointment as an adjunct Assistant Professor at Brown University in affiliation with the Center for Digital Health. Dr. Kaplan received her PhD in Clinical Psychology from the University of Arizona, completed her predoctoral clinical internship at the Alpert Medical School of Brown University, and completed a postdoctoral research fellowship at Brown University, where she received an F32 National Research Service Award (NRSA) from the National Institutes of Health (NIH). Her research is funded by the NIH, the Health Resources Services Administration (HRSA), the Georgia Clinical and Translational Science Alliance, the Tiny Blue Dot Foundation, and the Vail Health Foundation among others. She was named as a 2025 Rising Star by Genomics Press for her work in mental health assessment innovation. Roman Palitsky Roman Palitsky, MDiv, Ph.D. is Director of Research Projects for Emory Spiritual Health and a Research Psychologist for Emory University School of Medicine. His research program investigates the pathways through which culture and health interact by examining the biological, psychological, and social processes that constitute these pathways. His areas of interest include biopsychosocial determinants in cardiovascular health, chronic pain, and grief. In collaboration with Emory Spiritual Health, his research addresses cultural and existential topics in healthcare such as religion, spirituality, and the way people find meaning in suffering, as they relate to health and illness. His work has also focused on the role of religious and existential worldviews in mindfulness-based interventions, as well as implementation and cultural responsiveness of these interventions. Dr. Palitsky's academic training includes a PhD in Clinical Psychology from the University of Arizona with a concentration in Behavioral Medicine/Health Psychology, and a Master of Divinity from Harvard University. He completed clinical internship in the behavioral medicine track at Brown University Warren Alpert Medical School, where he also completed a postdoctoral fellowship. Deanna and Roman were in town attending and speaking at the 2025 SSSR Conference, Society for the Scienific Study of Religion. And as you will hear, we get deep into the spirit of sauna, a spiritual connection we allow ourselves to have, presented to us through the wonderfulness of time on the bench and chilling out in the garden, all misty wet with rain.

In April, Robert F. Kennedy Jr held a press conference about rising diagnoses of autism, and said he would soon be announcing a study to find the responsible agent. Although Kennedy said that environmental factors are the main cause of autism, research has shown that genetics plays a bigger part. Also, the rise in prevalence, many researchers say, is predominantly caused by an increase in diagnoses rather than a true rise in the underlying symptoms and traits.Although the US National Institutes of Health (NIH) announced a US$50 million to fund studies on the causes of autism, many researchers were dismayed that these developments seemed to ignore decades of work on the well-documented rise in diagnoses and on causes of the developmental condition.This is an audio version of our Feature: Autism is on the rise — what's really behind the increase? Hosted on Acast. See acast.com/privacy for more information.

The mechanisms behind Alzheimer's disease have eluded scientists for decades. But a new breakthrough points to lithium as a possible explanation—not only does it occur naturally in the brain, but a deficiency causes dementia in mice. This research is one of thousands of projects that have lost funding due to President Trump's cuts to the National Institutes of Health (NIH). Host Ira Flatow speaks with Alzheimer's researcher Bruce Yankner about this new finding, and then to epidemiologist Katelyn Jetelina and immunologist Elisabeth Marnik about the country's “quiet engine of science,” the NIH.Guests: Dr. Bruce Yankner is professor of genetics and neurology at Harvard Medical School in Boston, Massachusetts.Dr. Katelyn Jetelina, epidemiologist and author of the Your Local Epidemiologist newsletter. She's based in San Diego.Dr. Elisabeth Marnik is an immunologist and Director of Science Education & Outreach at the MDI Biological Laboratory in Bar Harbor, Maine.Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

My guest is Dr. Jay Bhattacharya, MD, PhD, Director of the National Institutes of Health (NIH) and Professor Emeritus of Health Policy at Stanford University. We discuss which scientific questions ought to be the priority for NIH, how to incentivize bold, innovative science especially from younger labs, how to solve the replication crisis and restore trust and transparency in science and public health, including acknowledging prior failures by the NIH. We discuss the COVID-19 pandemic and the data and sociological factors that motivated lockdowns, masking and vaccine mandates. Dr. Bhattacharya shares his views on how to resolve the vaccine–autism debate and how best to find the causes and cures for autism and chronic diseases. The topics we cover impact everyone: male, female, young and old and, given that NIH is the premier research and public health organization in the world, extend to Americans and non-Americans alike. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman David: https://davidprotein.com/huberman Eight Sleep: https://eightsleep.com/huberman Levels: ⁠https://levels.link/huberman⁠ LMNT: https://drinklmnt.com/huberman Timestamps 00:00:00 Jay Bhattacharya 00:06:56 National Institutes of Health (NIH), Mission 00:09:12 Funding, Basic vs. Applied Research 00:18:22 Sponsors: David & Eight Sleep 00:21:20 Indirect Costs (IDC), Policies & Distribution 00:30:43 Taxpayer Funding, Journal Access, Public Transparency 00:38:14 Taxpayer Funding, Patents; Drug Costs in the USA vs Other Countries 00:48:50 Reducing Medication Prices; R&D, Improving Health 01:00:01 Sponsors: AG1 & Levels 01:02:55 Lowering IDC?, Endowments, Monetary Distribution, Scientific Groupthink 01:12:29 Grant Review Process, Innovation 01:21:43 R01s, Tenure, Early Career Scientists & Novel Ideas 01:31:46 Sociology of Grant Evaluation, Careerism in Science, Failures 01:39:08 “Sick Care” System, Health Needs 01:44:01 Sponsor: LMNT 01:45:33 Incentives in Science, H-Index, Replication Crisis 01:58:54 Scientists, Data Fraud, Changing Careers 02:03:59 NIH & Changing Incentive Structure, Replication, Pro-Social Behavior 02:15:26 Scientific Discovery, Careers & Changing Times, Journals & Publications 02:19:56 NIH Grants & Appeals, Under-represented Populations, DEI 02:28:58 Inductive vs Deductive Science; DEI & Grants; Young Scientists & NIH Funding 02:39:38 Grant Funding, Identity & Race; Shift in NIH Priorities 02:51:23 Public Trust & Science, COVID Pandemic, Lockdowns, Masks 03:04:41 Pandemic Mandates & Economic Inequality; Fear; Public Health & Free Speech 03:13:39 Masks, Harms, Public Health Messaging, Uniformity, Groupthink, Vaccines 03:22:48 Academic Ostracism, Public Health Messaging & Opposition 03:30:26 Culture of American Science, Discourse & Disagreement 03:36:03 Vaccines, COVID Vaccines, Benefits & Harms 03:47:05 Vaccine Mandates, Money, Public Health Messaging, Civil Liberties 03:54:52 COVID Vaccines, Long-Term Effects; Long COVID, Vaccine Injury, Flu Shots 04:06:47 Do Vaccines Cause Autism?; What Explains Rise in Autism 04:18:33 Autism & NIH; MAHA & Restructuring NIH? 04:25:47 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

My guest is Dr. Christopher Gardner, Ph.D., professor of medicine and director of nutrition studies at Stanford. He is known for his pioneering research on the impact of dietary interventions on weight loss and health. We compare ketogenic, vegetarian, vegan and omnivorous diets—and why there is no one-size-fits-all approach. All agree, however, that eliminating or dramatically reducing processed foods is best for health. We discuss the protein needs controversy; plant vs. animal proteins; the importance of fiber and low-sugar fermented foods for gut health and inflammation; and how diet affects gene expression. We also review food allergies—including gluten, wheat, dairy and soy—as well as raw dairy. The episode offers data-supported advice for healthier eating. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman Mateina: https://drinkmateina.com/huberman BetterHelp: https://betterhelp.com/huberman LMNT: https://drinklmnt.com/huberman Levels: https://levelshealth.com/huberman Timestamps 00:00:00 Christopher Gardner 00:02:32 Is there a Best Diet?, Individual Needs, Geography & Diet, Lactose 00:11:02 Sponsors: Eight Sleep & Mateina 00:13:49 Raw Milk, Lactose Intolerance 00:20:33 Wheat Allergies, Gluten Intolerance; Celiac Disease 00:25:12 Processed Foods, Food Dyes, Research Outcomes, NOVA Classification, GRAS 00:33:44 Processed Foods, Economic & Time Considerations, US vs European Products 00:39:59 Food Industry Funding, Investigator Influence, Equipoise, Transparency 00:50:10 Sponsors: AG1 & BetterHelp 00:53:11 Industry Funding, National Institute of Health (NIH) 00:56:41 Whole Food, Plant-Based Diet; Diet Comparison, DIETFITS, A TO Z Study 01:10:24 Nutrition Naming, Omnivore, Meat, Animal Feeding Operations (CAFO) 01:17:14 Transforming American Diet; Taste, Health & Environment 01:22:26 Sponsor: LMNT 01:23:43 Food Preparation, Chefs, Improve School Food 01:29:54 Scalability, Mega-Farms, Small Farm & Farmer Loss 01:34:25 Protein Requirements, Dietary Protein Recommendations, Standard Deviations 01:45:33 Protein & Storage 01:52:12 Plants & Complete Proteins?, Legumes, Bioavailability 02:01:58 Sponsor: Levels 02:03:17 Beyond Meat, Impossible Meat, Ingredients, Sourcing Meat, Salt 02:09:18 Vegan vs Omnivore Diet, Twin Study, Cardiometabolic Markers, Genes, Microbiome 02:20:24 Health Science Communication, DEXA; “Protein Flip” Diet; Food Patterns, Caloric Intake 02:31:29 Microbiome, Inflammation, Fiber, Tool: Low-Sugar, Fermented Food 02:45:32 Acknowledgements 02:47:55 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures