Podcasts about Cochrane Library

DITCH YOUR DOCTOR! https://www.livelongerformula.com/wam Get a natural health practitioner and work with Christian Yordanov! Mention WAM and get a FREE masterclass! You will ALSO get a FREE metabolic function assessment! HELP SUPPORT US AS WE DOCUMENT HISTORY HERE: https://gogetfunding.com/help-wam-cover-history/ GET NON-MRNA FREEZE DRIED MEAT HERE: https://wambeef.com/ Use code WAMBEEF to save 20%! GET HEIRLOOM SEEDS & NON GMO SURVIVAL FOOD HERE: https://heavensharvest.com/ USE Code WAM to save 5% plus free shipping! GET YOUR APRICOT SEEDS at the life-saving Richardson Nutritional Center HERE: https://rncstore.com/r?id=bg8qc1 Use code JOSH to save money! Josh Sigurdson reports on a landmark study out of the prestigious International Journal Of Preventative Medicine in March which studies 85 million people and puts together 15 studies including 11 controlled studies and 4 studies without a control group to give a more broad view. The studies include those from PubMed, Web of Science, Scopus, Cochrane Library and Google Scholar until October 22nd, 2023. The studies show an enormous increase in not just overall death rates but also in specific ailments including heart attack, stroke and arrhythmia, specifically showing massive increases by Pfizer's BNT162b2 vaccines and AstraZeneca's ChAdOx1 vaccines but also looks at Moderna. There are increases in things like arrhythmia that reach as high as 711% following injection and multiple cases of increases in coronary artery disease, myocardial infarction and stroke above 200%. The most common things one dies from are seeing massive increases only after being vaxxed. This is an indictment on the injections and something we already knew. The difference is that we are seeing this study with 85 million people involved and when combined with 3 other studies, we actually see a combined total of 184 million people involved overall. As the governments of the world continue to push Bird Flu after the Covid hoax and go after the animals while trying to force inject us and even RFK Jr is promoting Measles MMR vaccines while not taking the mRNA Covid Vaccines out of the childhood vaccine schedule, expect the continuation of fearmongering and further restrictions going into the future. This is a eugenics operation after all. Prepare yourselves outside of the pharma system as well as remove yourself from depending on the banks, grocery stores and government. Stay tuned for more from WAM! Get local, healthy, pasture raised meat delivered to your door here: https://wildpastures.com/promos/save-20-for-life/bonus15?oid=6&affid=321 USE THE LINK & get 20% off for life and $15 off your first box! SIGN UP FOR HOMESTEADING COURSES NOW: https://freedomfarmers.com/link/17150/ Get Prepared & Start The Move Towards Real Independence With Curtis Stone's Courses! GET YOUR WAV WATCH HERE: https://buy.wavwatch.com/WAM Use Code WAM to save $100 and purchase amazing healing frequency technology! GET ORGANIC CHAGA MUSHROOMS HERE: https://alaskachaga.com/wam Use code WAM to save money! See shop for a wide range of products! GET AMAZING MEAT STICKS HERE: https://4db671-1e.myshopify.com/discount/WAM?rfsn=8425577.918561&utm_source=refersion&utm_medium=affiliate&utm_campaign=8425577.918561 USE CODE WAM TO SAVE MONEY! GET YOUR FREEDOM KELLY KETTLE KIT HERE: https://patriotprepared.com/shop/freedom-kettle/ Use Code WAM and enjoy many solutions for the outdoors in the face of the impending reset! BUY GOLD HERE: https://firstnationalbullion.com/schedule-consult/ PayPal: ancientwonderstelevision@gmail.com FIND OUR CoinTree page here: https://cointr.ee/joshsigurdson JOIN US on SubscribeStar here: https://www.subscribestar.com/world-alternative-media For subscriber only content! Pledge here! Just a dollar a month can help us alive! https://www.patreon.com/user?u=2652072&ty=h&u=2652072 BITCOIN ADDRESS: 18d1WEnYYhBRgZVbeyLr6UfiJhrQygcgNU World Alternative Media 2025

Is Robert F. Kennedy, Jr., just a big crank? Well, yes. But is he nevertheless correct in his specific claims about the harms of water fluoridation? It's long been argued that it's no longer necessary, and that it might have the scary adverse effect of lowering children's IQs. In this episode of The Studies Show, Tom and Stuart look at the evidence.While they're at it, Tom and Stuart ask whether there's evidence for several other dentistry-related claims. Regular check-ups; flossing; fillings; fluoride toothpaste—is your dentist just b**********g you about any or all of these?[This podcast was recorded just before Donald Trump selected RFK Jr. as his candidate for US Health Secretary, but that makes the episode even more relevant].The Studies Show is brought to you by Works in Progress magazine. If you're an optimist who enjoys reading about how things have gotten better in the past, and how we might make them better in the future—then it's the magazine for you. Find it at worksinprogress.co. Show notes* RFK Jr.'s tweet about how the new Trump administration will remove fluoride from the US water supply* US National Research Council's 2006 report on fluoridation* 2023 meta-analysis on water fluoridation and IQ* Letter co-authored by Stuart, criticising a bad study on fluoride and IQ in pregnant women and their babies* The original study* Review of fluoridation and cancer risk* 2000 UK NHS review of fluoridation and cancer risk* 2022 UK Government report on the link of water fluoridation to various different medical conditions* 2024 Cochrane Review on fluoridation and preventing tooth decay* Review of guidelines from the Journal of the American Dental Association* 2020 randomised controlled trial on fillings in children's teeth* The Cochrane Library on the evidence for specific intervals between dental appointments (e.g. 6 months)* The American Dental Association guidelines on flossing, and the NHS ones* 2019 Cochrane review of RCTs of flossing* The ADA and NHS guidelines on brushing with fluoride toothpaste* 2019 Cochrane review on brushing and fluoride* Claims about cardiac health being related to dental health* Study of 1m people in Korea on cardiac health and tooth loss* 2020 meta-analysis of cardiac and dental health* The study included in the meta-analysis by Chen, Chen, Lin, and Chen* Claims about dental health and cancer* 2020 review of the literature* 2024 Ars Technica story on dentists over-selling their services* 2019 Atlantic piece: “Is Dentistry a Science?”* 2013 piece in the Washington State Dental News magazine on “creative diagnosis”* Articles in the British Dental Journal and JAMA Internal Medicine both arguing that evidence-based medicine has left dentistry behindCredits The Studies Show is produced by Julian Mayers at Yada Yada Productions. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.thestudiesshowpod.com/subscribe

Check the end of any recent study, and there will be a list of study funders and disclosures about competing interests. It's important to know about potential biases in research, but this kind of transparency was not always the norm. Understanding bias in research and helping policymakers use the most reliable evidence to guide their decisions is a science in itself. Lisa Bero, a professor at the University of Colorado Anschutz Medical Campus, has been at the forefront of understanding how corporate funding biases research and how to assess what scientific evidence is reliable. She talks to host Monya Baker about her investigations into the tobacco and pharmaceutical industries, techniques industries use to shape evidence to favor their products, and the importance of independent research to inform policy.  Resources:  Read The Cigarette Papers to learn more about Lisa Bero and others' investigations of the tobacco industry.  See this analysis of industry documents about insider knowledge of health effects of PFAS and related chemicals.  Visit the Cochrane Library to find more systematic reviews of clinical research.  Learn more about Adrian Traeger's investigation of spinal cord stimulation research by reading Corporate Influences on Science and Health—the Case of Spinal Cord Stimulation. Read Lisa Bero's summary of how industry forces suppress unfavorable research.  Lisa Bero and others are developing a tool to screen for signs of fraud in clinical research. Learn more about it in The Conversation. 

The Cochrane Library contains several reviews on the effects of different ways of organising and delivering medical care. One of these reviews, published in March 2024, summarises the evidence on models for delivering medical care to older adults living in residential aged care facilities. In this podcast, Liesl Grobler talks with lead author, Polina Putrik, both from Monash University in Melbourne, Australia, about the review.

The Cochrane Library contains several reviews on the effects of different ways of organising and delivering medical care. One of these reviews, published in March 2024, summarises the evidence on models for delivering medical care to older adults living in residential aged care facilities. In this podcast, Liesl Grobler talks with lead author, Polina Putrik, both from Monash University in Melbourne, Australia, about the review.

EVIDENCE-BASED BIRTH PRACTICES MAKE BIRTH HEALTHIER AND SAFER FOR MOTHERS AND BABIESAt The Eudaimonia Center, we know what makes birth safe for mothers and babies AND standard maternity care in the United States is not evidence-based and does not reflect this knowledge. Therefore, the health-care provider and place of birth will influence the care that Mom receives in powerful ways. The result is that birth is less safe for mothers and babies than it should be, causing harm where it could be avoided.The World Health Organization identifies four care practices that promote, support, and protect normal birth. Lamaze International identifies two additional practices. Together, these six practices are supported by research, including systematic reviews from The Cochrane Library and the Coalition for Improving Maternity Services (2007). Written for women and their families, the Lamaze Healthy Birth Practice papers describe the importance of each of the six practices for a healthy, safe birth and provide a synopsis of the evidence that supports each practice. Every pregnant woman needs to know that these six evidence-based birth practices make birth healthier and safer for mothers and babies.Healthy Birth Practice #1: Let Labor Begin on Its OwnHealthy Birth Practice #2: Walk, Move Around, and Change Positions Throughout LaborHealthy Birth Practice #3: Bring a Loved One, Friend, or Doula for Continuous SupportHealthy Birth Practice #4: Avoid Interventions That Are Not Medically NecessaryHealthy Birth Practice #5: Avoid Giving Birth on the Back, and Follow the Body's Urges to PushHealthy Birth Practice #6: Keep Mother and Baby Together – It's Best for Mother, Baby, and BreastfeedingBirth is intended to happen simply... without worry or trouble.About Our Guest:Gina Mundy is an attorney specializing in childbirth cases. For over 20 years, her focus has been investigating and analyzing mistakes that arise during labor and delivery. She has spent countless hours meticulously scrutinizing childbirth cases, conducting interviews with delivery teams, and thoroughly examining medical records to gain an in-depth understanding of every decision made during labor and delivery. Throughout her career, Gina has traveled nationwide, engaging with healthcare professionals such as doctors, nurses, and midwives to explore all aspects of labor and delivery. These interactions have provided her with invaluable insights, enabling her to appreciate the diverse perspectives prevalent in different regions of the country. Resources Mentioned:A Parent's Guide to a Safter ChildbirthConnect with Gina:WebsiteFacebookInstagramLinkedInThe hashtag for the podcast is #nourishyourflourish. You can also find our practice on the following social media outlets:Facebook: The Eudaimonia CenterInstagram: theeudaimoniacenterTwitter: eu_daimonismFor more reproductive medicine and women's health information and other valuable resources, make sure to visit our website.Have a question, comment, guest suggestion, or want to share your story? Email us at info@laurenawhite.comSupport the show

The Cochrane Library contains many reviews relevant to the management of low back pain, one of the common health problems in the world. This includes reviews of what to look out for when someone presents with low back pain and the review of red flags that would highlight the need to screen for a spinal fracture was updated in August 2023. Here's Chris Han from the Institute for Musculoskeletal Health and the University of Sydney in Australia to describe the latest findings.

The Cochrane Library contains many reviews relevant to the management of low back pain, one of the common health problems in the world. This includes reviews of what to look out for when someone presents with low back pain and the review of red flags that would highlight the need to screen for a spinal fracture was updated in August 2023. Here's Chris Han from the Institute for Musculoskeletal Health and the University of Sydney in Australia to describe the latest findings.

Can we have science without freedom of speech? Dr. Scott Atlas's professional work and personal experiences bring to light an important and often under-discussed element of speech: freedom of speech in the hard sciences. The COVID-19 pandemic ushered in a host of new questions and concerns surrounding our medical system and government health agencies: as Special Advisor to the President and a member of the White House Coronavirus Task Force from July to December 2020, Dr. Atlas was at the forefront of such debates. In this conversation, he discusses the importance of debate not only to science itself but also to popular trust in and support of the sciences, which since the pandemic have suffered a steep decline. Dr. Scott Atlas, MD, is the Robert Wesson Senior Fellow in health care policy at the Hoover Institution of Stanford University and the co-director of the Global Liberty Institute. In addition to his role in White House he has served as Senior Advisor for Health Care to several numerous candidates for President, as well as counselled members of the U.S. Congress on health care, testified before Congress, and briefed directors of key federal agencies. Before his appointment at Hoover Institution, he was a Professor and Chief of Neuroradiology at Stanford University Medical Center for 14 years, and he received his medical degree from the University of Chicago School of Medicine. He is the author of numerous books, most recently A Plague Upon Our House: My Fight at the Trump White House to Stop COVID from Destroying America. Here is the Cochrane Library analysis on masking mentioned during the interview. Annika Nordquist is the Communications Coordinator of Princeton University's James Madison Program in American Ideals and Institutions and host of the Program's podcast, Madison's Notes.

Can we have science without freedom of speech? Dr. Scott Atlas's professional work and personal experiences bring to light an important and often under-discussed element of speech: freedom of speech in the hard sciences. The COVID-19 pandemic ushered in a host of new questions and concerns surrounding our medical system and government health agencies: as Special Advisor to the President and a member of the White House Coronavirus Task Force from July to December 2020, Dr. Atlas was at the forefront of such debates. In this conversation, he discusses the importance of debate not only to science itself but also to popular trust in and support of the sciences, which since the pandemic have suffered a steep decline. Dr. Scott Atlas, MD, is the Robert Wesson Senior Fellow in health care policy at the Hoover Institution of Stanford University and the co-director of the Global Liberty Institute. In addition to his role in White House he has served as Senior Advisor for Health Care to several numerous candidates for President, as well as counselled members of the U.S. Congress on health care, testified before Congress, and briefed directors of key federal agencies. Before his appointment at Hoover Institution, he was a Professor and Chief of Neuroradiology at Stanford University Medical Center for 14 years, and he received his medical degree from the University of Chicago School of Medicine. He is the author of numerous books, most recently A Plague Upon Our House: My Fight at the Trump White House to Stop COVID from Destroying America. Here is the Cochrane Library analysis on masking mentioned during the interview. Annika Nordquist is the Communications Coordinator of Princeton University's James Madison Program in American Ideals and Institutions and host of the Program's podcast, Madison's Notes. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network

Can we have science without freedom of speech? Dr. Scott Atlas's professional work and personal experiences bring to light an important and often under-discussed element of speech: freedom of speech in the hard sciences. The COVID-19 pandemic ushered in a host of new questions and concerns surrounding our medical system and government health agencies: as Special Advisor to the President and a member of the White House Coronavirus Task Force from July to December 2020, Dr. Atlas was at the forefront of such debates. In this conversation, he discusses the importance of debate not only to science itself but also to popular trust in and support of the sciences, which since the pandemic have suffered a steep decline. Dr. Scott Atlas, MD, is the Robert Wesson Senior Fellow in health care policy at the Hoover Institution of Stanford University and the co-director of the Global Liberty Institute. In addition to his role in White House he has served as Senior Advisor for Health Care to several numerous candidates for President, as well as counselled members of the U.S. Congress on health care, testified before Congress, and briefed directors of key federal agencies. Before his appointment at Hoover Institution, he was a Professor and Chief of Neuroradiology at Stanford University Medical Center for 14 years, and he received his medical degree from the University of Chicago School of Medicine. He is the author of numerous books, most recently A Plague Upon Our House: My Fight at the Trump White House to Stop COVID from Destroying America. Here is the Cochrane Library analysis on masking mentioned during the interview. Annika Nordquist is the Communications Coordinator of Princeton University's James Madison Program in American Ideals and Institutions and host of the Program's podcast, Madison's Notes. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science

Can we have science without freedom of speech? Dr. Scott Atlas's professional work and personal experiences bring to light an important and often under-discussed element of speech: freedom of speech in the hard sciences. The COVID-19 pandemic ushered in a host of new questions and concerns surrounding our medical system and government health agencies: as Special Advisor to the President and a member of the White House Coronavirus Task Force from July to December 2020, Dr. Atlas was at the forefront of such debates. In this conversation, he discusses the importance of debate not only to science itself but also to popular trust in and support of the sciences, which since the pandemic have suffered a steep decline. Dr. Scott Atlas, MD, is the Robert Wesson Senior Fellow in health care policy at the Hoover Institution of Stanford University and the co-director of the Global Liberty Institute. In addition to his role in White House he has served as Senior Advisor for Health Care to several numerous candidates for President, as well as counselled members of the U.S. Congress on health care, testified before Congress, and briefed directors of key federal agencies. Before his appointment at Hoover Institution, he was a Professor and Chief of Neuroradiology at Stanford University Medical Center for 14 years, and he received his medical degree from the University of Chicago School of Medicine. He is the author of numerous books, most recently A Plague Upon Our House: My Fight at the Trump White House to Stop COVID from Destroying America. Here is the Cochrane Library analysis on masking mentioned during the interview. Annika Nordquist is the Communications Coordinator of Princeton University's James Madison Program in American Ideals and Institutions and host of the Program's podcast, Madison's Notes. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/politics-and-polemics

Can we have science without freedom of speech? Dr. Scott Atlas's professional work and personal experiences bring to light an important and often under-discussed element of speech: freedom of speech in the hard sciences. The COVID-19 pandemic ushered in a host of new questions and concerns surrounding our medical system and government health agencies: as Special Advisor to the President and a member of the White House Coronavirus Task Force from July to December 2020, Dr. Atlas was at the forefront of such debates. In this conversation, he discusses the importance of debate not only to science itself but also to popular trust in and support of the sciences, which since the pandemic have suffered a steep decline. Dr. Scott Atlas, MD, is the Robert Wesson Senior Fellow in health care policy at the Hoover Institution of Stanford University and the co-director of the Global Liberty Institute. In addition to his role in White House he has served as Senior Advisor for Health Care to several numerous candidates for President, as well as counselled members of the U.S. Congress on health care, testified before Congress, and briefed directors of key federal agencies. Before his appointment at Hoover Institution, he was a Professor and Chief of Neuroradiology at Stanford University Medical Center for 14 years, and he received his medical degree from the University of Chicago School of Medicine. He is the author of numerous books, most recently A Plague Upon Our House: My Fight at the Trump White House to Stop COVID from Destroying America. Here is the Cochrane Library analysis on masking mentioned during the interview. Annika Nordquist is the Communications Coordinator of Princeton University's James Madison Program in American Ideals and Institutions and host of the Program's podcast, Madison's Notes. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science-technology-and-society

Can we have science without freedom of speech? Dr. Scott Atlas's professional work and personal experiences bring to light an important and often under-discussed element of speech: freedom of speech in the hard sciences. The COVID-19 pandemic ushered in a host of new questions and concerns surrounding our medical system and government health agencies: as Special Advisor to the President and a member of the White House Coronavirus Task Force from July to December 2020, Dr. Atlas was at the forefront of such debates. In this conversation, he discusses the importance of debate not only to science itself but also to popular trust in and support of the sciences, which since the pandemic have suffered a steep decline. Dr. Scott Atlas, MD, is the Robert Wesson Senior Fellow in health care policy at the Hoover Institution of Stanford University and the co-director of the Global Liberty Institute. In addition to his role in White House he has served as Senior Advisor for Health Care to several numerous candidates for President, as well as counselled members of the U.S. Congress on health care, testified before Congress, and briefed directors of key federal agencies. Before his appointment at Hoover Institution, he was a Professor and Chief of Neuroradiology at Stanford University Medical Center for 14 years, and he received his medical degree from the University of Chicago School of Medicine. He is the author of numerous books, most recently A Plague Upon Our House: My Fight at the Trump White House to Stop COVID from Destroying America. Here is the Cochrane Library analysis on masking mentioned during the interview. Annika Nordquist is the Communications Coordinator of Princeton University's James Madison Program in American Ideals and Institutions and host of the Program's podcast, Madison's Notes. Learn more about your ad choices. Visit megaphone.fm/adchoices

Can we have science without freedom of speech? Dr. Scott Atlas's professional work and personal experiences bring to light an important and often under-discussed element of speech: freedom of speech in the hard sciences. The COVID-19 pandemic ushered in a host of new questions and concerns surrounding our medical system and government health agencies: as Special Advisor to the President and a member of the White House Coronavirus Task Force from July to December 2020, Dr. Atlas was at the forefront of such debates. In this conversation, he discusses the importance of debate not only to science itself but also to popular trust in and support of the sciences, which since the pandemic have suffered a steep decline. Dr. Scott Atlas, MD, is the Robert Wesson Senior Fellow in health care policy at the Hoover Institution of Stanford University and the co-director of the Global Liberty Institute. In addition to his role in White House he has served as Senior Advisor for Health Care to several numerous candidates for President, as well as counselled members of the U.S. Congress on health care, testified before Congress, and briefed directors of key federal agencies. Before his appointment at Hoover Institution, he was a Professor and Chief of Neuroradiology at Stanford University Medical Center for 14 years, and he received his medical degree from the University of Chicago School of Medicine. He is the author of numerous books, most recently A Plague Upon Our House: My Fight at the Trump White House to Stop COVID from Destroying America. Here is the Cochrane Library analysis on masking mentioned during the interview. Annika Nordquist is the Communications Coordinator of Princeton University's James Madison Program in American Ideals and Institutions and host of the Program's podcast, Madison's Notes. Learn more about your ad choices. Visit megaphone.fm/adchoices

This is a re release of one of our most listened to episodes! Be sure you don't miss it this time around!It's common for people to ask what they can do to prepare themselves for labor and birth. On today's episode, we will talk about it all…exercises to do, foods to eat, things to drink, and practitioners to see!Mentioned articles:EBB 216 - The Evidence on Prenatal Perineal Massage for Preventing Tears in Childbirth with Dr. Rebecca Dekker - Evidence Based Birth®EBB 128 - Inducing Labor with Castor Oil and Dates - Evidence Based Birth®February 9, 2021, systematic review published in BMC Complementary Medicine and Therapies evaluated 6 databases (CINAHL, MEDLINE, Cochrane Library, Scopus, Web of Science Core Collection, and AMED database)Mentioned Instragram people to follow:MamasteFit: Gina & Roxanne (@mamastefit) • Instagram photos and videosPUSH fitness (@pushfitmom) • Instagram photos and videosPlease feel free to reach out to us with any recommendations for show episode ideas. If you'd like to be a guest, email us with some information about yourself and what type of podcast you'd like to record together. Thank you for all of your support and don't forget to follow and review our podcast, Birth, Baby!Instagram: @‌BirthBabyPodcastEmail: BirthBabyPodcast@gmail.comWebsite: https://birthbabypodcast.transistor.fm/Intro and Outro music by Longing for Orpheus. You can find them on Spotify!

Indah G & Joshua Kenji sit down with psychologists Astrid Ramadhani and Yolanda Pasaribu (M.Psi) to ask them all of the uncomfortable, awkward and certainly taboo questions that behind closed doors, everyone secretly wonders regarding mental health. Has mental illness become somewhat trendy amongst Gen-Z's and Gen-Alphas these days? Are certain clients claiming to have some form of mental illness when they actually don't? What constitutes s*icidality? Does it also include wishing you were never born, in which case then, isn't everyone s*icidal to some extent? Astrid, Indah, Joshua & Yolanda also get very deep and personal into their faiths (or lack thereof for some), and philosophies of hope, gratitude, perseverance, and life purpose. Timestamps: 00:00 — Intro 00:28 — Self-proclaimed experts, self-diagnosing, ill for attention, dealing with loved ones that are depressed/s*icidal 09:46 — Is mental illness now trendy? Seeking for attention or reaching out? 19:25 — How to handle s*icidal family/peers? 22:39 — Sharing personal issues on social media vs personal message 27:22 — S*icide rate in Indonesia and data statistics regarding mental health issues, differences between male and female in therapy 33:55 — Toxic friend groups and trauma-bonding, to leave or not to leave? Lack of support system and fear of being left out 44:26 — Family's perspective and religious views on mental health issues 49:28 — Aspects in having a religion that contributes in preventing or developing mental health issues 55:24 — Mental illness diagnosis between the east and west, self-diagnosing due to limited resources, therapy options to deal with each problems 1:03:48 — Trauma coping mechanism/outlets 1:07:41 — Triangle of Needs; do you really need to seek therapy? How mental health professionals do assessments before diagnosis 1:16:35 — Fomo of having mental illness 1:20:24 — Are you abusing your mental health professionals? 1:22:41 — Differences between therapy and counselling, different attitudes while going into therapy, seeking validation from therapists? 1:33:36 — Is everyone depressed? Indah's s*icidal tendencies and existential issues 1:50:29 — Active vs passive s*icidality 1:53:11 — When is medically assisted s*icide okay? 2:02:07 — Fan message on s*icide, having purpose in life For those interested in seeking counseling/therapy services from mental health services in Jakarta: IndoPsyCare is an evidence-based, scientifically-backed, international-standard psychology clinic based in Jakarta, Indonesia. Their clinician-scientists adhere to international standards outlined within the Cochrane Library and the Clinical Guidelines set forth by the UK-based National Institute for Health and Care Excellence (NICE) coupled with the Indonesian IPK Clinical Guidelines (Panduan Nasional Praktik Psikologi Klinis, PNPPK). They welcome both English-speaking clients, as well as local Bahasa Indonesia speaking clients. Visit indopsycare.com to learn more, as well as book your first consultation.

¡Episodio 1535 de "El Siglo 21 es Hoy"! En este episodio del pódcast El Siglo 21 es Hoy, exploramos el mundo de las gafas con filtro azul y el negocio detrás de ellas. Descubrimos que, aunque estas gafas se promocionan como la solución para proteger nuestros ojos de los efectos perjudiciales de las pantallas, un estudio reciente revela que puede que no sean tan efectivas como se nos ha hecho creer. Además, investigamos el fenómeno de las personas que usan gafas con filtro azul sin necesitarlas solo por su apariencia, y reflexionamos sobre la importancia de mirar menos nuestras pantallas y disfrutar del mundo real. También abordamos el impacto de las pantallas en los niños y los consejos de expertos sobre su uso adecuado. Y para aquellos preocupados por cuidar sus ojos de los efectos del uso excesivo de pantallas, ofrecemos una guía divertida y útil para proteger tus ojos en la era digital. No te pierdas este episodio lleno de información interesante, reflexiones y un toque de humor. ¡Cuida tus ojos y disfruta del podcast!00:00 Episodio 153509:02 Luz Azul14:33 Pantallas23:13 El estudio30:21 El precio extra34:49 Niñas y niños40:06 Paisajes Sonoros¿Y qué hago yo para cuidar mis ojos de las pantallas?Guía para Salvar tus Ojos del Apocalipsis DigitalUna era donde la frase "Tengo ojo de águila" ha sido reemplazada por "Tengo ojo rojo de tanto mirar pantallas”Recuerda, la salud ocular es vital. Pero un poco de humor nunca viene mal, ¡cuida esos ojos! ;)1. Distancia y postura: No nos equivoquemos. La "postura adecuada" no significa estirarte en el sofá como una medusa derretida mientras sostienes tu móvil con una mano y un paquete de patatas fritas con la otra. Y por distancia no nos referimos a poner el móvil al otro lado de la habitación para hacer zoom con los ojos.2. Ambiente de trabajo: Por supuesto, tener buena luz, humedad y ventilación. Aunque, honestamente, es más probable que la mayoría de nosotros acabemos en una cueva oscura con un ordenador, una lámpara de escritorio y un ventilador que suena como si estuviera a punto de despegar.3. Descansos: Sí, esa famosa regla 20/20. Pero, ¡espera! También hay otra: 20-6-20. ¿No es esto como recordar todas las contraseñas que debemos cambiar cada mes?4. Lágrimas Artificiales: Puede que llores lágrimas reales al recordar cómo era la vida antes de las pantallas, pero estas lágrimas artificiales son para esos momentos en que tus ojos se sienten como el desierto del Sahara.5. Consulta al Doctor de Ojos: No al vecino que dice saberlo todo porque "lo leyó en Internet". A tu OFTALMÓLOGO. Aunque claro, no me sorprendería si próximamente hay un "Dr. Google Ocular" en la esquina.6. Medidas extremas: Si sientes que tus ojos están siendo atacados por diminutos pixeles rebeldes, ¡amplía todo al 150%! Así, en lugar de parecer que estás leyendo el periódico, parecerá que estás mirando las letras del oculista.7. Edad y pantalla: ¿Estás entre los 40 y 55 años? Bueno, querido lector, la presbicia te ha encontrado. No, no es una secta secreta, es un fenómeno ocular. ¡No desesperes! Tu optometrista te espera con brazos abiertos (y probablemente con una factura).8. Yoga Ocular: Sí, has leído bien. No, no es una broma. Ahora bien, intentar poner tus ojos en posición del loto podría ser... problemático.9. Configuración del computador: Si terminas usando anteojos de abuela para ver el texto, probablemente sea hora de ajustar el brillo y el contraste. Y no, pegar una linterna al monitor no cuenta como ajuste de brillo.Epílogo: Si después de todos estos consejos todavía sientes que tus ojos están pidiendo clemencia, quizás sea el momento de recordar cómo es la vida fuera de la pantalla. O al menos intentarlo.Bibliografía: "Efectos de la exposición a pantallas en la salud visual y física de los niños y jóvenes: una revisión sistemática" - Cochrane Library https://www.cochranelibrary.com/es/cdsr/doi/10.1002/14651858.CD013244.pub2/full/es"Tiempo de pantalla y niños: Cómo guiar a los niños" - Mayo Clinic https://www.mayoclinic.org/healthy-lifestyle/childrens-health/in-depth/screen-time/art-20047952"Tiempo de pantalla para bebés y niños pequeños: ¿Cuánto es demasiado?" - UNICEF https://www.unicef.org/parenting/child-development/babies-screen-time"Explicación de AMOLED, OLED y POLED: Entendiendo las diferencias" - Android Police https://www.androidpolice.com/amoled-oled-poled-explainer/"Lentes con filtro de luz azul: ¿Realmente protegen tus ojos?" - CNN Español https://cnnespanol.cnn.com/2023/08/22/lentes-filtro-luz-azul-no-protegen-ojos-estudio-trax/"¿Sirve de algo el filtro de luz azul en las gafas?" - El Confidencial https://www.alimente.elconfidencial.com/bienestar/2023-09-03/sirve-para-algo-filtro-luz-azul-gafas_3726971/"La efectividad de las gafas con filtro de luz azul" - Specsavers España https://www.specsavers.es/gafas/guia-de-lentes/efectividad-gafas-luz-azulThis show is part of the Spreaker Prime Network, if you are interested in advertising on this podcast, contact us at https://www.spreaker.com/show/880846/advertisement

From Langley BC, Canada - July 8th from One Big Tent secular AA day - there is a doctor in the house. Retired Addiction Medicine Dr. Ray B talks about Recovery Capital and other science findings about people in recovery from addiction that inform positive outcome rates. We cover the 4 C's of our altered brain with addictionLoss of ControlConsequencesCompulsionCravingSeligman's recipe for recovery, resilience, growth and healthPositive EmotionsEngagementSupportive RelationsMeaningAchievementEMDR, positive emotions embedded in the 12 steps and more.This is the opener at the first British Columbia secular AA day so we also meet from members visiting from Canada and the USA. More about secular AA: https://aasecular.org  Secular AA is AA sobriety without the God-stuff, one of the fastest growing subcultures within Alcoholics Anonymous offering 100 agnostic/atheist/freethinkers AA meetings every day + regional events and the International Conference of Secular AA (ICSAA). More @ https://aasecular.org

It's common for people to ask what they can do to prepare themselves for labor and birth. On today's episode, we will talk about it all…exercises to do, foods to eat, things to drink, and practitioners to see!SummaryIn this episode, Ciarra and Samantha discuss how to prepare for labor and birth. They emphasize the importance of education, knowing your options, and taking a well-rounded childbirth class. They also talk about the benefits of exercise during pregnancy, including walking, prenatal yoga, and strength exercises. The hosts highlight the significance of nutrition, such as consuming high protein and high fiber foods, and getting essential vitamins and minerals. They also stress the importance of staying hydrated with water. Overall, the episode provides valuable information and tips for preparing for labor and birth. In this episode, the hosts discuss various methods that can help prepare the body for labor, including drinking red raspberry leaf tea, eating dates, and practicing perineal massage. They also touch on the benefits of chiropractic care, pelvic floor therapy, and acupuncture. While some of these methods have limited scientific evidence, they emphasize the importance of listening to your body and finding what works best for you. They also acknowledge that not everyone has access to or can afford these methods, and suggest alternative options like spinning babies exercises and self-performed perineal massage.TakeawaysTake a well-rounded childbirth class to learn about your options for labor and birth.Engage in regular exercise during pregnancy to build stamina and strength.Focus on nutrition by consuming high protein and high fiber foods and getting essential vitamins and minerals.Stay hydrated with water and limit caffeine intake.Be in tune with your body and listen to its needs throughout pregnancy. Drinking red raspberry leaf tea, eating dates, and practicing perineal massage are thought to help prepare the body for labor, although the scientific evidence is limited.Chiropractic care, pelvic floor therapy, and acupuncture can also be beneficial in preparing the body for labor.It's important to listen to your body and find what works best for you, as not all methods may be effective for everyone.Alternative options like spinning babies exercises and self-performed perineal massage can be helpful for those who cannot access or afford other methods.Mentioned articles:EBB 216 - The Evidence on Prenatal Perineal Massage for Preventing Tears in Childbirth with Dr. Rebecca Dekker - Evidence Based Birth®EBB 128 - Inducing Labor with Castor Oil and Dates - Evidence Based Birth®February 9, 2021, systematic review published in BMC Complementary Medicine and Therapies evaluated 6 databases (CINAHL, MEDLINE, Cochrane Library, Scopus, Web of Science Core Collection, and AMED database)Mentioned Instragram people to follow:MamasteFit: Gina & Roxanne (@mamastefit) • Instagram photos and videosPUSH fitness (@pushfitmom) • Instagram photos and videosPlease feel free to reach out to us with any recommendations for show episode ideas. If you'd like to be a guest, email us with some information about yourself and what type of podcast you'd like to record together. Thank you for all of your support and don't forget to follow and review our podcast, Birth, Baby!Instagram: @‌BirthBabyPodcastEmail: BirthBabyPodcast@gmail.comWebsite: https://birthbabypodcast.transistor.fm/Intro and Outro music by Longing for Orpheus. You can find them on Spotify! (00:00) - Preparing for Labor and Birth: Education and Options (07:50) - Exercise During Pregnancy: Building Stamina and Strength (11:54) - Nutrition During Pregnancy: High Protein and High Fiber Foods (24:55) - Being in Tune with Your Body: Listening to its Needs (30:51) - Preparing the Body for Labor: Red Raspberry Leaf Tea, Dates, and Perineal Massage (33:02) - Additional Methods for Labor Preparation: Chiropractic Care, Pelvic Floor Therapy, and Acupuncture (44:10) - Perineal Massage and Scar Tissue (50:52) - Balancing the Body: Chiropractic Care, Pelvic Floor Therapy, and Acupuncture (58:23) - Alternative Options for Labor Preparation: Spinning Babies Exercises and Self-Performed Perineal Massage

Cochrane Library's recently published article questioning the clinical benefit of spinal cord stimulation for low back pain has stirred controversy throughout the pain medicine community. In response to these findings, we sat down with neuromodulation specialists & Pain Medicine journal editorial board members,  Zachary McCormick, MD, and Nathaniel M. Schuster, MD, to offer our in-depth reaction and analysis of the March 2023 report. In this episode of the Pain Matters Podcast, host Shravani Durbhakula, MD, MPH, MBA, and co-host @Mustafa Broachwala, DO, are joined by Zachary McCormick, MD, Chief of Spine and Musculoskeletal Medicine at the University of Utah & Nathaniel M. Schuster, MD, Associate Clinical Director of the Center for Pain Medicine at UC San Diego. We are live in-person at AAPM's 39th Annual Meeting in Fort Lauderdale, FL, to discuss the implications of the Cochrane Library's spinal cord stimulation review and what it means for providers and patients. Additionally, David Caraway, MD, PhD, Chief Medical Officer of Nevro Corp., calls in to give his expert insight on the controversial inclusion and exclusion of certain studies and how this impacts the conclusions of the review. Lastly, we go to Vwaire Orhurhu MD, MPH, author of a widely-read letter to the editor published in JAMA in response to the Hara et al. study, which is critical to the Cochrane Library Review's conclusions.Tune in to discover:In-depth scientific analysis and reaction to the curious findings, generalizations, and omissions from the reviewHow to interpret the Cochrane Library's recent findings and what they actually might mean for clinical practice. What this review means for patient care and the future of SCS in pain medicine Reference: Traeger AC, Gilbert SE, Harris IA, Maher CG. Spinal cord stimulation for low back pain. Cochrane Database of Systematic Reviews 2023, Issue 3. Art. No.: CD014789. DOI: 10.1002/14651858.CD014789.pub2. Accessed 29 March 2023.

Although the numbers may be low, COVID-19 and other illnesses remain a significant threat to patients. The role of masks in preventing SARS-CoV-2 spread has been politicized since the beginning. A new meta-analysis purports to answer the question of mask effectiveness. Join host Geoff Wall, with guest Jake Galdo, as they deep dive into the article and evaluate the science.The GameChangerA new meta-analysis suggests that mask mandates do not affect the prevention and spread of COVID-19. However, the study has numerous limitations and errors, making its interpretation difficult.Show Segments00:00 - Introductions01:31 - Pros and Cons of a Meta-Analysis06:31: Looking at the Analysis10:24 - The GameChanger: Jefferson et al. Results11:24 - Connecting to Practice: Recognizing Limitations28:43 - Closing Remarks HostGeoff Wall, PharmD, BCPS, FCCP, CGPProfessor of Pharmacy Practice, Drake UniversityInternal Medicine/Critical Care, UnityPoint HealthJake Galdo, PharmD, MBA, BCPS, BCGPCourse Content and Developer, CEimpactManaging Network Facilitator, CPESN Health EquityCEO, SeguridadReferences and ResourcesJefferson T, Dooley L, Ferroni E, et al. Physical interventions to interrupt or reduce the spread of respiratory viruses (Review). Cochrane Library.  Novella S. Masks Revisited. Science Based Medicine. Redeem your CPE hereCPE (Pharmacist) Get a membership & earn CE for GameChangers Podcast episodes (30 mins/episode)Pharmacists: Get a membershipCE InformationLearning ObjectivesUpon successful completion of this knowledge-based activity, participants should be able to:1. Discuss the pros and cons of a meta-analysis2. Describe the limitations of the Jefferson et al meta-analysis0.05 CEU/0.5 HrUAN: 0107-0000-23-119-H01-PInitial release date: 03/22/2023Expiration date: 03/22/2024Additional CPE and CME details can be found here.Follow CEimpact on Social Media:LinkedInInstagramDownload the CEimpact App for Free Continuing Education + so much more!

Today we return to the ongoing story of the train car derailment in East Palestine, Ohio where we have still not seen Pete Buttigieg or the Biden Administration doing anything substantive about it. Our Transportation Secretary is more worried about whether or not construction sites have enough demographic representation than he is about the nations road and railways. Residents, after being told just two days after officials decided to ignite the chemicals to burn them off instead of doing a proper clean-up, that they could return home, they are now suggesting drinking bottled water. People have been back in their homes for 6-7 days and they are just now suggesting bottled water. Plus, EPA officials are suggesting a heavy dusting around homes where dust gathers to collect any particulates. And, by the way, they said the particulates are too small for masks to be effective. Remember, viruses that are even smaller are supposedly defeated by a mask, but not toxic chemicals floating in the air. After that, we look at just how bad the Administration is at lying about inflation, wages and the economy. Karine Jean-Pierre is incapable of saying anything of substance without just reading from prepared talking points. It just so happens, whomever wrote the talking points is trying to gaslight the entire country into thinking inflation is down, wages are up and Biden's economic policies are giving us room to breathe. You cannot make this up, folks. And, on top of that, the whole “room to breathe” line is an anecdote Biden has been telling for so long, it's just another line he repeats without thinking. And it's ironic the topic of masks came up related to the chemical contamination in East Palestine. I mentioned this before, but wanted to bring it up again for the benefit of the audience. The Cochrane Library, considered one of the most well respected and esteemed research centers in the world, determined that masks made little to no difference throughout the entire Covid-19 pandemic. What's amazing is how something so “newsworthy” is not worthy of so many news outlets, including the New York Times and the Washington Post. Yet, those same sources have run thousands of stories on how to wear them, how to pick them out, which ones are better and even repeated studies shown to be shoddy in their work only because it supported the narrative. Similarly, the CDC is equally quiet about the worldwide study. It's as if journalists are really not interested in the news, just in telling you what they want you to believe. Take a moment to rate and review the show and then share the episode on social media. You can find me on Facebook, Twitter, Instagram, GETTR and TRUTH Social by searching for The Alan Sanders Show. You can also support the show by visiting my Patreon page!  

The Rich Zeoli Show- Hour 2:  In a Wall Street Journal opinion editorial, Jamie Metzl and Matt Pottinger argue that Congress needs to immediately establish a commission to determine the origins of the COVID-19 pandemic. Metzl and Pottinger write, “[t]hat Democrats control the Senate and Republicans control the House provides a unique opportunity for responsible, hard-hitting hearings in both chambers. There's no reason this should become an exercise in partisan point-scoring. Getting to the bottom of how this avoidable human catastrophe began—and adopting measures to prevent similar ones—should naturally be a unifying initiative.” Read the full editorial at: https://www.wsj.com/articles/we-still-dont-know-the-truth-about-covid-wuhan-lab-virology-pandemic-source-gain-of-function-who-research-accountability-china-congress-11675893326?mod=opinion_lead_pos5 Two of the beagles rescued from a puppy mill used by Dr. Anthony's Fauci's National Institute of Allergy and Infectious Diseases (NIAID) will participate in this year's Puppy Bowl competition. During an interview with CNN Business, Microsoft co-founder Bill Gates insisted that he's not a hypocrite for using a private jet while concurrently warning society about fossil fuel-caused climate change. While speaking at the Center for Strategic & International Studies, Treasury Secretary Janet Yellen implored the World Bank to do more in addressing climate change. Meanwhile, Rep. Alexandria Ocasio- Cortez (D-NY) is calling for the establishment of tax credits to cover the consumer costs of electric bikes. According to a review published by the Cochrane Library, the Centers for Disease Control and Prevention (CDC) exaggerated the effectiveness of surgical masks reducing the likelihood of COVID-19 infection. 

The Rich Zeoli Show- Full Episode (02/09/2023): 3:05pm- On Wednesday, Philadelphia Police Officer Giovanni Maysonet was shot twice during an investigation in West Philadelphia. Thankfully, Officer Maysonet was wearing a protective bulletproof vest at the time of the shooting. He is now in stable condition following surgery at Penn Presbyterian Hospital. The alleged shooters have been arrested.  3:10pm- According to a report from former FBI Special Agent Kyle Seraphin, a Federal Bureau of Investigation (FBI) field office recently released a memo warning of “radical traditionalist Catholic ideology.” You can read the article at: https://www.uncoverdc.com/2023/02/08/the-fbi-doubles-down-on-christians-and-white-supremacy-in-2023/ 3:15pm- On Thursday, a Congressional Judiciary subcommittee held a hearing on the weaponization, and subsequent overt politicization, of the Justice Department. During the hearing Senator Chuck Grassley (R-IA) explained, "I have run countless investigations and...I've never seen so much effort from the FBI, the partisan media, and some of my Democrat colleagues to interfere with and undermine very legitimate congressional inquiries." He also pointed to evidence that indicates that the FBI is aware of “potential criminal conduct” by Hunter Biden.  3:45pm- During Thursday's Congressional Judiciary subcommittee hearing, Rep. Elise Stefanik (R-NY) noted that, according to polling, a significant percentage of Democrats would have changed their vote in the 2020 presidential election had they been aware that the Hunter Biden laptop story wasn't “Russian disinformation” like many intel officials and media members originally proclaimed. 3:55pm- Senator Ron Johnson (R-WI) implored officials to release the unredacted emails of former National Institute of Allergy and Infectious Diseases (NIAID) director Dr. Anthony Fauci, in hopes of determining whether or not the United States provided funding for dangerous gain-of-function research in China. 4:05pm- In a Wall Street Journal opinion editorial, Jamie Metzl and Matt Pottinger argue that Congress needs to immediately establish a commission to determine the origins of the COVID-19 pandemic. Metzl and Pottinger write, “[t]hat Democrats control the Senate and Republicans control the House provides a unique opportunity for responsible, hard-hitting hearings in both chambers. There's no reason this should become an exercise in partisan point-scoring. Getting to the bottom of how this avoidable human catastrophe began—and adopting measures to prevent similar ones—should naturally be a unifying initiative.” Read the full editorial at: https://www.wsj.com/articles/we-still-dont-know-the-truth-about-covid-wuhan-lab-virology-pandemic-source-gain-of-function-who-research-accountability-china-congress-11675893326?mod=opinion_lead_pos5 4:25pm- Two of the beagles rescued from a puppy mill used by Dr. Anthony's Fauci's National Institute of Allergy and Infectious Diseases (NIAID) will participate in this year's Puppy Bowl competition. 4:35pm- During an interview with CNN Business, Microsoft co-founder Bill Gates insisted that he's not a hypocrite for using a private jet while concurrently warning society about fossil fuel-caused climate change. 4:45pm- While speaking at the Center for Strategic & International Studies, Treasury Secretary Janet Yellen implored the World Bank to do more in addressing climate change. Meanwhile, Rep. Alexandria Ocasio- Cortez (D-NY) is calling for the establishment of tax credits to cover the consumer costs of electric bikes. 4:50pm- According to a review published by the Cochrane Library, the Centers for Disease Control and Prevention (CDC) exaggerated the effectiveness of surgical masks reducing the likelihood of COVID-19 infection.  5:05pm- During Thursday's Congressional Judiciary subcommittee hearing, Rep. Elise Stefanik (R-NY) warned of “systemic rot” within the FBI, specifically referencing leadership culture. 5:10pm- Former Congresswoman Tulsi Gabbard spoke during a Congressional Judiciary subcommittee hearing and condemned Senator Mitt Romney (R-UT) for referring to her as a “traitor.”  5:30pm- Senator John Fetterman (D-PA) was hospitalized on Wednesday night after feeling lightheaded at a Democrat retreat. According to reports, the symptoms are not believed to be related to the stroke Fetterman suffered in 2022. 5:45pm- Florida Governor Ron DeSantis responded to attacks leveled against him by former President Donald Trump.  5:50pm- While speaking with Judy Woodruff on PBS NewsHour, President Joe Biden denied that shooting down a Chinese reconnaissance balloon will negatively impact his relationship with Xi Jinping.  5:55pm- Caller Greg wants to hear Rich scream at Matt and Henry more frequently. PLUS Mama Zeoli broadcasts LIVE from the Hindenburg disaster? We have the exclusive audio. 6:05pm- During Tuesday night's State of the Union Address, President Joe Biden accused Republicans of wanting to slash Medicare and Social Security. Speaker of the House Kevin McCarthy (R-CA) stated that Biden's allegations are false. Meanwhile, Zeoli plays audio from Biden's time as a U.S. Senator where he explicitly calls for cuts to Medicare and Social Security... 6:25pm- Zeoli hilariously yells at Henry for playing music too loudly overtop of his segment opens—Caller Greg must be elated.  6:35pm- While speaking in front of a state House Health Committee hearing in Tennessee, political commentator Matt Walsh asked, “do you really think a 16-year-old can consent to having body parts removed?” referencing gender affirming surgery on children. The Committee was, notably, left speechless.  6:45pm- Philadelphia Eagles star wide receiver DeVonta Smith admits that he doesn't like cheesesteaks. 

This is Garrison Hardie with your CrossPolitic Daily Newsbrief for Wednesday, February 8th, 2023. Rowdy Christian Merch Plug: If you’re a fan of CrossPolitic, or the Fight Laugh Feast Network, then surely, you know we have a merch store right? Rowdy Christian Merch is your one-stop-shop for everything CrossPolitc merchandise. We’ve got T-Shirts, hoodies, hats, but we’ve also got specialty items like backpacks, mugs, coffee, even airpod cases! Visit Rowdy Christian Merch at rowdychristian.com, and buy that next gift, or a little something for yourself. Again, that’s rowdychristian.com. An update on the situation in Turkey & Syria: https://www.theepochtimes.com/earthquake-death-toll-crosses-5000-as-turkey-experiences-285-aftershocks_5039212.html?utm_source=partner&utm_campaign=BonginoReport&src_src=partner&src_cmp=BonginoReport Earthquake Death Toll Passes 7,200 as Turkey Experiences 285 Aftershocks The death toll from the earthquakes in Turkey and Syria have exceeded 7,200, with thousands more injured, infrastructure crumbling, and rescue groups struggling to bring aid to the victims. In Turkey, at least 5,434 people are confirmed dead. In Syria, state news agency SANA reported at least 1,832 deaths. Combined, at least 7,266 people have died in Turkey and Syria. In total, at least 3,749 people are estimated to have been injured in Syria. Turkey’s injured are estimated to be over 30,000. The World Health Organization (WHO) warned that the death toll could rise to around 20,000 in the coming days. The first quake, with an epicenter in the Pazarcik district of Turkey’s southern Province, had a magnitude of 7.8. A second quake of 7.6 magnitude hit the same region nine hours later, worsening the situation. Turkey experienced 285 aftershocks. U.S. President Joe Biden “noted that U.S. teams are deploying quickly to support Turkish search and rescue efforts and coordinate other assistance that may be required by people affected by the earthquakes, including health services or basic relief items,” a readout of Biden’s conversation with Turkish President on Jan. 6 said. The earthquakes have caused widespread devastation in Turkey. A video shared on Twitter shows innumerable buildings turned to rubble, with only a few tall buildings still standing. Another video shows a building crashing down while people run for safety. In Turkey’s southern region, which is home to some of the worst-hit cities, damaged roads and poor internet connections are hampering rescue attempts. In some places, freezing winter weather is also posing a challenge. Families were forced to sleep in cars lined up in the streets. Families wrapped themselves in blankets and gathered around fires to keep themselves warm. The Disaster and Emergency Management Presidency of Turkey (AFAD) is said to have deployed 13,740 search and rescue personnel as well as over 300,000 blankets, 100,000 beds, and 41,000 tents to the region. According to Organ Tatar, an official from AFAD, 5,775 buildings have been destroyed by the quake. “The infrastructure is damaged, the roads that we used to use for humanitarian work are damaged, we have to be creative in how to get to the people … but we are working hard,” U.N. resident coordinator -told Reuters. The earthquake on Monday is Turkey’s deadliest since a quake of similar magnitude hit the country in 1999 and killed over 17,000 people. https://www.dailyfetched.com/massive-human-trafficking-bust-sees-368-arrested-131-rescued-in-california-2/ Massive Human Trafficking Bust Sees 368 Arrested, 131 Rescued in California Three hundred sixty-eight people have been arrested, and 131 victims rescued in large-scale human trafficking operation by a multi-agency task force in California. Los Angeles Police Department (LAPD) Chief Michel Moore said: “We know that the sex trade is a prolific one that exists throughout this state and throughout our nation.” “It’s an ugly scar against this great country that exists too oftentimes in plain sight,” he added. Operation Reclaim and Rebuild occurred between Jan. 22 and Jan. 28 in nine counties, including Los Angeles, Orange, and San Bernardino, Kiro7 reported. Various federal, state, and local law enforcement agencies teamed up for the effort, including the LAPD, the Los Angeles County Sheriff’s Department, and the Los Angeles County District Attorney’s Office. Victims of human trafficking, including ages ranging from 13 to 52, including children. Investigators worked with victim advocacy groups to provide resources “to help [victims] escape from this life-threatening environment,” he said. Investigators responded to advertisements offering sexual services and visited massage parlors suspected of being involved in sex trafficking. Among those arrested included pimps and panderers, Moore said. The victims, most of whom were kidnapped, face “threat of death” or coercion and are isolated from their former support to become dependent on the trafficker, Moore added. https://thepostmillennial.com/death-tourism-oregon-becomes-national-destination-for-assisted-suicide?utm_campaign=64487 'Death tourism': Oregon becomes national destination for assisted suicide Individuals residing in states that outlaw euthanasia, such as Texas, have started traveling to Oregon to gain assistance in their suicide, making the state the first "death tourism" destination in the US. According to the Daily Mail, Dr. Nicholas Gideonse, the director of End of Life Choices Oregon, recently admitted to assisting a man from Texas with Lou Gehrig's disease who came to the doctor's Portland clinic in achieving suicide and said that "for a small number of patients who otherwise qualify or are determined to go through that and who have the energy and the resources … it has started to happen." According to Oregon's official website, the state passed its Death with Dignity Act in 1997, "which allows terminally ill individuals to end their lives through the voluntary self-administration of lethal medications, expressly prescribed by a physician for that purpose." The law enabled terminally ill patients expected to die within six months to request fatal drugs from doctors that the patient then takes and self-administers. In 2021, 238 people committed suicide via the program, and 383 doses of fatal drugs were prescribed by doctors. There was originally a restriction for people out-of-state but in 2021 Dr. Gideonse sued Oregon to lift the restriction, which was granted in 2022. Currently, if a resident from another state wants to go to Oregon for the fatal drugs, they are placed on a 15-day waiting period. In that time paperwork is processed and two doctors along with witnesses must sign off on the request for suicide by prescription. The expansion of Death with Dignity to out-of-staters is not yet law in Oregon but is expected to be codified this year with House Bill 2279. The law resembles Canada's state-sponsored euthanasia program known as medical assistance in dying (MAiD), originally intended for those with physical illnesses where death was a reasonable inevitability although it has been amended to allow those with mental health issues to apply. Dr. Gideonse's original lawsuit was over neighboring residents of Washington who wanted suicide drugs and has expanded to residents from further states, including those with strict laws against euthanasia. The executive director of the Patients Rights Action Fund, a group pushing back against Oregon's law, Matt Vallière, said "You end up in this Wild West scenario where people take the drugs back to their home states, and there are a lot more questions than there are answers about what would happen after that." Dr. Gideonse, who also has campaigned for legalizing psilocybin to treat depression, has connections with the Compassion & Choices group which "grew out of the 1980s right-to-die movement of the Hemlock Society and Jack Kevorkian — the pathologist and notorious 'Dr Death' who assisted scores of suicides and was ultimately convicted of murder," reports the Daily Mail. Tucker Carlson & Charles Camosy spoke on this very subject. https://rumble.com/v1adg4j-charles-camosy-on-the-way-assisted-suicide-is-increasingly-being-pushed.html - Play Video Classical Conversations Classical Conversations supports homeschooling parents by cultivating the love of learning through a Christian worldview in fellowship with other families. They provide a classical Christ-centered curriculum, local like-minded communities across the United States and in several countries, and they train parents who are striving to be great classical educators in the home. For more information and to get connected, please visit their website at ClassicalConversations.com. Again that’s ClassicalConversations.com. https://freebeacon.com/coronavirus/this-study-could-be-scientific-nail-in-the-coffin-for-masks/ This Study Could Be 'Scientific Nail in the Coffin' for Masks One of the largest and most comprehensive studies on the effectiveness of masks found they do almost nothing to reduce the spread of respiratory viruses. The study reviewed 78 randomized control trials—experiments that have long been considered "the gold standard" for medicine—which assessed the effectiveness of face masks against flu, COVID-19, and similar illnesses. It found that wearing masks "probably makes little or no difference" for the general public, no matter what kind of mask is used. Even N95 masks, considered the most effective at filtering airborne particles, showed no clear benefit for health care workers. The study was published on January 30 by the Cochrane Library, a world-renowned medical database that is famous for its high-quality evidence reviews. It comes as a battering ram to the recommendations of the U.S. public health establishment, which urged children as young as two to wear masks throughout the pandemic. https://www.fox10phoenix.com/news/person-stuck-on-the-side-of-downtown-phoenix-building-says-phoenix-fire-dept 'Pro-life Spiderman' taken into custody after scaling former Chase tower in Phoenix https://www.youtube.com/watch?v=QcaLtpAM0fE - Play 0:00-1:22 And that’s your news for today…

This is Garrison Hardie with your CrossPolitic Daily Newsbrief for Wednesday, February 8th, 2023. Rowdy Christian Merch Plug: If you’re a fan of CrossPolitic, or the Fight Laugh Feast Network, then surely, you know we have a merch store right? Rowdy Christian Merch is your one-stop-shop for everything CrossPolitc merchandise. We’ve got T-Shirts, hoodies, hats, but we’ve also got specialty items like backpacks, mugs, coffee, even airpod cases! Visit Rowdy Christian Merch at rowdychristian.com, and buy that next gift, or a little something for yourself. Again, that’s rowdychristian.com. An update on the situation in Turkey & Syria: https://www.theepochtimes.com/earthquake-death-toll-crosses-5000-as-turkey-experiences-285-aftershocks_5039212.html?utm_source=partner&utm_campaign=BonginoReport&src_src=partner&src_cmp=BonginoReport Earthquake Death Toll Passes 7,200 as Turkey Experiences 285 Aftershocks The death toll from the earthquakes in Turkey and Syria have exceeded 7,200, with thousands more injured, infrastructure crumbling, and rescue groups struggling to bring aid to the victims. In Turkey, at least 5,434 people are confirmed dead. In Syria, state news agency SANA reported at least 1,832 deaths. Combined, at least 7,266 people have died in Turkey and Syria. In total, at least 3,749 people are estimated to have been injured in Syria. Turkey’s injured are estimated to be over 30,000. The World Health Organization (WHO) warned that the death toll could rise to around 20,000 in the coming days. The first quake, with an epicenter in the Pazarcik district of Turkey’s southern Province, had a magnitude of 7.8. A second quake of 7.6 magnitude hit the same region nine hours later, worsening the situation. Turkey experienced 285 aftershocks. U.S. President Joe Biden “noted that U.S. teams are deploying quickly to support Turkish search and rescue efforts and coordinate other assistance that may be required by people affected by the earthquakes, including health services or basic relief items,” a readout of Biden’s conversation with Turkish President on Jan. 6 said. The earthquakes have caused widespread devastation in Turkey. A video shared on Twitter shows innumerable buildings turned to rubble, with only a few tall buildings still standing. Another video shows a building crashing down while people run for safety. In Turkey’s southern region, which is home to some of the worst-hit cities, damaged roads and poor internet connections are hampering rescue attempts. In some places, freezing winter weather is also posing a challenge. Families were forced to sleep in cars lined up in the streets. Families wrapped themselves in blankets and gathered around fires to keep themselves warm. The Disaster and Emergency Management Presidency of Turkey (AFAD) is said to have deployed 13,740 search and rescue personnel as well as over 300,000 blankets, 100,000 beds, and 41,000 tents to the region. According to Organ Tatar, an official from AFAD, 5,775 buildings have been destroyed by the quake. “The infrastructure is damaged, the roads that we used to use for humanitarian work are damaged, we have to be creative in how to get to the people … but we are working hard,” U.N. resident coordinator -told Reuters. The earthquake on Monday is Turkey’s deadliest since a quake of similar magnitude hit the country in 1999 and killed over 17,000 people. https://www.dailyfetched.com/massive-human-trafficking-bust-sees-368-arrested-131-rescued-in-california-2/ Massive Human Trafficking Bust Sees 368 Arrested, 131 Rescued in California Three hundred sixty-eight people have been arrested, and 131 victims rescued in large-scale human trafficking operation by a multi-agency task force in California. Los Angeles Police Department (LAPD) Chief Michel Moore said: “We know that the sex trade is a prolific one that exists throughout this state and throughout our nation.” “It’s an ugly scar against this great country that exists too oftentimes in plain sight,” he added. Operation Reclaim and Rebuild occurred between Jan. 22 and Jan. 28 in nine counties, including Los Angeles, Orange, and San Bernardino, Kiro7 reported. Various federal, state, and local law enforcement agencies teamed up for the effort, including the LAPD, the Los Angeles County Sheriff’s Department, and the Los Angeles County District Attorney’s Office. Victims of human trafficking, including ages ranging from 13 to 52, including children. Investigators worked with victim advocacy groups to provide resources “to help [victims] escape from this life-threatening environment,” he said. Investigators responded to advertisements offering sexual services and visited massage parlors suspected of being involved in sex trafficking. Among those arrested included pimps and panderers, Moore said. The victims, most of whom were kidnapped, face “threat of death” or coercion and are isolated from their former support to become dependent on the trafficker, Moore added. https://thepostmillennial.com/death-tourism-oregon-becomes-national-destination-for-assisted-suicide?utm_campaign=64487 'Death tourism': Oregon becomes national destination for assisted suicide Individuals residing in states that outlaw euthanasia, such as Texas, have started traveling to Oregon to gain assistance in their suicide, making the state the first "death tourism" destination in the US. According to the Daily Mail, Dr. Nicholas Gideonse, the director of End of Life Choices Oregon, recently admitted to assisting a man from Texas with Lou Gehrig's disease who came to the doctor's Portland clinic in achieving suicide and said that "for a small number of patients who otherwise qualify or are determined to go through that and who have the energy and the resources … it has started to happen." According to Oregon's official website, the state passed its Death with Dignity Act in 1997, "which allows terminally ill individuals to end their lives through the voluntary self-administration of lethal medications, expressly prescribed by a physician for that purpose." The law enabled terminally ill patients expected to die within six months to request fatal drugs from doctors that the patient then takes and self-administers. In 2021, 238 people committed suicide via the program, and 383 doses of fatal drugs were prescribed by doctors. There was originally a restriction for people out-of-state but in 2021 Dr. Gideonse sued Oregon to lift the restriction, which was granted in 2022. Currently, if a resident from another state wants to go to Oregon for the fatal drugs, they are placed on a 15-day waiting period. In that time paperwork is processed and two doctors along with witnesses must sign off on the request for suicide by prescription. The expansion of Death with Dignity to out-of-staters is not yet law in Oregon but is expected to be codified this year with House Bill 2279. The law resembles Canada's state-sponsored euthanasia program known as medical assistance in dying (MAiD), originally intended for those with physical illnesses where death was a reasonable inevitability although it has been amended to allow those with mental health issues to apply. Dr. Gideonse's original lawsuit was over neighboring residents of Washington who wanted suicide drugs and has expanded to residents from further states, including those with strict laws against euthanasia. The executive director of the Patients Rights Action Fund, a group pushing back against Oregon's law, Matt Vallière, said "You end up in this Wild West scenario where people take the drugs back to their home states, and there are a lot more questions than there are answers about what would happen after that." Dr. Gideonse, who also has campaigned for legalizing psilocybin to treat depression, has connections with the Compassion & Choices group which "grew out of the 1980s right-to-die movement of the Hemlock Society and Jack Kevorkian — the pathologist and notorious 'Dr Death' who assisted scores of suicides and was ultimately convicted of murder," reports the Daily Mail. Tucker Carlson & Charles Camosy spoke on this very subject. https://rumble.com/v1adg4j-charles-camosy-on-the-way-assisted-suicide-is-increasingly-being-pushed.html - Play Video Classical Conversations Classical Conversations supports homeschooling parents by cultivating the love of learning through a Christian worldview in fellowship with other families. They provide a classical Christ-centered curriculum, local like-minded communities across the United States and in several countries, and they train parents who are striving to be great classical educators in the home. For more information and to get connected, please visit their website at ClassicalConversations.com. Again that’s ClassicalConversations.com. https://freebeacon.com/coronavirus/this-study-could-be-scientific-nail-in-the-coffin-for-masks/ This Study Could Be 'Scientific Nail in the Coffin' for Masks One of the largest and most comprehensive studies on the effectiveness of masks found they do almost nothing to reduce the spread of respiratory viruses. The study reviewed 78 randomized control trials—experiments that have long been considered "the gold standard" for medicine—which assessed the effectiveness of face masks against flu, COVID-19, and similar illnesses. It found that wearing masks "probably makes little or no difference" for the general public, no matter what kind of mask is used. Even N95 masks, considered the most effective at filtering airborne particles, showed no clear benefit for health care workers. The study was published on January 30 by the Cochrane Library, a world-renowned medical database that is famous for its high-quality evidence reviews. It comes as a battering ram to the recommendations of the U.S. public health establishment, which urged children as young as two to wear masks throughout the pandemic. https://www.fox10phoenix.com/news/person-stuck-on-the-side-of-downtown-phoenix-building-says-phoenix-fire-dept 'Pro-life Spiderman' taken into custody after scaling former Chase tower in Phoenix https://www.youtube.com/watch?v=QcaLtpAM0fE - Play 0:00-1:22 And that’s your news for today…

This is Garrison Hardie with your CrossPolitic Daily Newsbrief for Wednesday, February 8th, 2023. Rowdy Christian Merch Plug: If you’re a fan of CrossPolitic, or the Fight Laugh Feast Network, then surely, you know we have a merch store right? Rowdy Christian Merch is your one-stop-shop for everything CrossPolitc merchandise. We’ve got T-Shirts, hoodies, hats, but we’ve also got specialty items like backpacks, mugs, coffee, even airpod cases! Visit Rowdy Christian Merch at rowdychristian.com, and buy that next gift, or a little something for yourself. Again, that’s rowdychristian.com. An update on the situation in Turkey & Syria: https://www.theepochtimes.com/earthquake-death-toll-crosses-5000-as-turkey-experiences-285-aftershocks_5039212.html?utm_source=partner&utm_campaign=BonginoReport&src_src=partner&src_cmp=BonginoReport Earthquake Death Toll Passes 7,200 as Turkey Experiences 285 Aftershocks The death toll from the earthquakes in Turkey and Syria have exceeded 7,200, with thousands more injured, infrastructure crumbling, and rescue groups struggling to bring aid to the victims. In Turkey, at least 5,434 people are confirmed dead. In Syria, state news agency SANA reported at least 1,832 deaths. Combined, at least 7,266 people have died in Turkey and Syria. In total, at least 3,749 people are estimated to have been injured in Syria. Turkey’s injured are estimated to be over 30,000. The World Health Organization (WHO) warned that the death toll could rise to around 20,000 in the coming days. The first quake, with an epicenter in the Pazarcik district of Turkey’s southern Province, had a magnitude of 7.8. A second quake of 7.6 magnitude hit the same region nine hours later, worsening the situation. Turkey experienced 285 aftershocks. U.S. President Joe Biden “noted that U.S. teams are deploying quickly to support Turkish search and rescue efforts and coordinate other assistance that may be required by people affected by the earthquakes, including health services or basic relief items,” a readout of Biden’s conversation with Turkish President on Jan. 6 said. The earthquakes have caused widespread devastation in Turkey. A video shared on Twitter shows innumerable buildings turned to rubble, with only a few tall buildings still standing. Another video shows a building crashing down while people run for safety. In Turkey’s southern region, which is home to some of the worst-hit cities, damaged roads and poor internet connections are hampering rescue attempts. In some places, freezing winter weather is also posing a challenge. Families were forced to sleep in cars lined up in the streets. Families wrapped themselves in blankets and gathered around fires to keep themselves warm. The Disaster and Emergency Management Presidency of Turkey (AFAD) is said to have deployed 13,740 search and rescue personnel as well as over 300,000 blankets, 100,000 beds, and 41,000 tents to the region. According to Organ Tatar, an official from AFAD, 5,775 buildings have been destroyed by the quake. “The infrastructure is damaged, the roads that we used to use for humanitarian work are damaged, we have to be creative in how to get to the people … but we are working hard,” U.N. resident coordinator -told Reuters. The earthquake on Monday is Turkey’s deadliest since a quake of similar magnitude hit the country in 1999 and killed over 17,000 people. https://www.dailyfetched.com/massive-human-trafficking-bust-sees-368-arrested-131-rescued-in-california-2/ Massive Human Trafficking Bust Sees 368 Arrested, 131 Rescued in California Three hundred sixty-eight people have been arrested, and 131 victims rescued in large-scale human trafficking operation by a multi-agency task force in California. Los Angeles Police Department (LAPD) Chief Michel Moore said: “We know that the sex trade is a prolific one that exists throughout this state and throughout our nation.” “It’s an ugly scar against this great country that exists too oftentimes in plain sight,” he added. Operation Reclaim and Rebuild occurred between Jan. 22 and Jan. 28 in nine counties, including Los Angeles, Orange, and San Bernardino, Kiro7 reported. Various federal, state, and local law enforcement agencies teamed up for the effort, including the LAPD, the Los Angeles County Sheriff’s Department, and the Los Angeles County District Attorney’s Office. Victims of human trafficking, including ages ranging from 13 to 52, including children. Investigators worked with victim advocacy groups to provide resources “to help [victims] escape from this life-threatening environment,” he said. Investigators responded to advertisements offering sexual services and visited massage parlors suspected of being involved in sex trafficking. Among those arrested included pimps and panderers, Moore said. The victims, most of whom were kidnapped, face “threat of death” or coercion and are isolated from their former support to become dependent on the trafficker, Moore added. https://thepostmillennial.com/death-tourism-oregon-becomes-national-destination-for-assisted-suicide?utm_campaign=64487 'Death tourism': Oregon becomes national destination for assisted suicide Individuals residing in states that outlaw euthanasia, such as Texas, have started traveling to Oregon to gain assistance in their suicide, making the state the first "death tourism" destination in the US. According to the Daily Mail, Dr. Nicholas Gideonse, the director of End of Life Choices Oregon, recently admitted to assisting a man from Texas with Lou Gehrig's disease who came to the doctor's Portland clinic in achieving suicide and said that "for a small number of patients who otherwise qualify or are determined to go through that and who have the energy and the resources … it has started to happen." According to Oregon's official website, the state passed its Death with Dignity Act in 1997, "which allows terminally ill individuals to end their lives through the voluntary self-administration of lethal medications, expressly prescribed by a physician for that purpose." The law enabled terminally ill patients expected to die within six months to request fatal drugs from doctors that the patient then takes and self-administers. In 2021, 238 people committed suicide via the program, and 383 doses of fatal drugs were prescribed by doctors. There was originally a restriction for people out-of-state but in 2021 Dr. Gideonse sued Oregon to lift the restriction, which was granted in 2022. Currently, if a resident from another state wants to go to Oregon for the fatal drugs, they are placed on a 15-day waiting period. In that time paperwork is processed and two doctors along with witnesses must sign off on the request for suicide by prescription. The expansion of Death with Dignity to out-of-staters is not yet law in Oregon but is expected to be codified this year with House Bill 2279. The law resembles Canada's state-sponsored euthanasia program known as medical assistance in dying (MAiD), originally intended for those with physical illnesses where death was a reasonable inevitability although it has been amended to allow those with mental health issues to apply. Dr. Gideonse's original lawsuit was over neighboring residents of Washington who wanted suicide drugs and has expanded to residents from further states, including those with strict laws against euthanasia. The executive director of the Patients Rights Action Fund, a group pushing back against Oregon's law, Matt Vallière, said "You end up in this Wild West scenario where people take the drugs back to their home states, and there are a lot more questions than there are answers about what would happen after that." Dr. Gideonse, who also has campaigned for legalizing psilocybin to treat depression, has connections with the Compassion & Choices group which "grew out of the 1980s right-to-die movement of the Hemlock Society and Jack Kevorkian — the pathologist and notorious 'Dr Death' who assisted scores of suicides and was ultimately convicted of murder," reports the Daily Mail. Tucker Carlson & Charles Camosy spoke on this very subject. https://rumble.com/v1adg4j-charles-camosy-on-the-way-assisted-suicide-is-increasingly-being-pushed.html - Play Video Classical Conversations Classical Conversations supports homeschooling parents by cultivating the love of learning through a Christian worldview in fellowship with other families. They provide a classical Christ-centered curriculum, local like-minded communities across the United States and in several countries, and they train parents who are striving to be great classical educators in the home. For more information and to get connected, please visit their website at ClassicalConversations.com. Again that’s ClassicalConversations.com. https://freebeacon.com/coronavirus/this-study-could-be-scientific-nail-in-the-coffin-for-masks/ This Study Could Be 'Scientific Nail in the Coffin' for Masks One of the largest and most comprehensive studies on the effectiveness of masks found they do almost nothing to reduce the spread of respiratory viruses. The study reviewed 78 randomized control trials—experiments that have long been considered "the gold standard" for medicine—which assessed the effectiveness of face masks against flu, COVID-19, and similar illnesses. It found that wearing masks "probably makes little or no difference" for the general public, no matter what kind of mask is used. Even N95 masks, considered the most effective at filtering airborne particles, showed no clear benefit for health care workers. The study was published on January 30 by the Cochrane Library, a world-renowned medical database that is famous for its high-quality evidence reviews. It comes as a battering ram to the recommendations of the U.S. public health establishment, which urged children as young as two to wear masks throughout the pandemic. https://www.fox10phoenix.com/news/person-stuck-on-the-side-of-downtown-phoenix-building-says-phoenix-fire-dept 'Pro-life Spiderman' taken into custody after scaling former Chase tower in Phoenix https://www.youtube.com/watch?v=QcaLtpAM0fE - Play 0:00-1:22 And that’s your news for today…

In this episode Associate Professor Jamie Hartmann-Boyce and Dr Nicola Lindson discuss the emerging evidence in e-cigarette research and summarise the findings of the newly published update to the Cochrane review of e-cigarettes for smoking cessation. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. In the November 2022 episode Jamie Hartmann-Boyce and Nicola Lindson bring us up to date with the latest findings from our Cochrane review of e-cigarettes for smoking cessation. The latest Cochrane Review finds high certainty evidence that nicotine e-cigarettes are more effective than traditional nicotine-replacement therapy (NRT) in helping people quit smoking. Jamie and Nicola summarise their research led by the University of Oxford, and funded by Cancer Research UK, which has found the strongest evidence yet that e-cigarettes, also known as 'vapes', help people to quit smoking better than traditional nicotine replacement therapies, such as patches and chewing gums. The new evidence published in the Cochrane Library finds high certainty evidence that people are more likely to stop smoking for at least six months using nicotine e-cigarettes, or 'vapes', than using nicotine replacement therapies, such as patches and gums. Evidence also suggested that nicotine e-cigarettes led to higher quit rates than e-cigarettes without nicotine, or no stop smoking intervention, but less data contributed to these analyses. The updated Cochrane review includes 78 studies in over 22,000 participants - an addition of 22 studies since the last update in 2021. Smoking is a significant global health problem. According to the World Health Organisation (WHO), in 2020, 22.3% of the global population used tobacco, despite it killing up to half of its users. Stopping smoking reduces the risk of lung cancer, heart attacks and many other diseases. Though most people who smoke want to quit, many find it difficult to do so permanently. Nicotine patches and gum are safe, effective and widely used methods to help individuals quit. E-cigarettes heat liquids with nicotine and flavourings, allowing users to 'vape' nicotine instead of smoking. Data from the review showed that if six in 100 people quit by using nicotine replacement therapy, eight to twelve would quit by using electronic cigarettes containing nicotine. This means an additional two to six people in 100 could potentially quit smoking with nicotine containing electronic cigarettes. For more information on the full Cochrane review updated in September 2021 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub7/full or our webpage https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 This podcast is supported by Cancer Research UK.

In this episode Associate Professor Jamie Hartmann-Boyce and Dr Nicola Lindson discuss the emerging evidence in e-cigarette research and summarise the findings of the newly published update to the Cochrane review of e-cigarettes for smoking cessation. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and shares the evidence from the monthly searches. In the November 2022 episode Jamie Hartmann-Boyce and Nicola Lindson bring us up to date with the latest findings from our Cochrane review of e-cigarettes for smoking cessation. The latest Cochrane Review finds high certainty evidence that nicotine e-cigarettes are more effective than traditional nicotine-replacement therapy (NRT) in helping people quit smoking. Jamie and Nicola summarise their research led by the University of Oxford, and funded by Cancer Research UK, which has found the strongest evidence yet that e-cigarettes, also known as 'vapes', help people to quit smoking better than traditional nicotine replacement therapies, such as patches and chewing gums. The new evidence published in the Cochrane Library finds high certainty evidence that people are more likely to stop smoking for at least six months using nicotine e-cigarettes, or 'vapes', than using nicotine replacement therapies, such as patches and gums. Evidence also suggested that nicotine e-cigarettes led to higher quit rates than e-cigarettes without nicotine, or no stop smoking intervention, but less data contributed to these analyses. The updated Cochrane review includes 78 studies in over 22,000 participants - an addition of 22 studies since the last update in 2021. Smoking is a significant global health problem. According to the World Health Organisation (WHO), in 2020, 22.3% of the global population used tobacco, despite it killing up to half of its users. Stopping smoking reduces the risk of lung cancer, heart attacks and many other diseases. Though most people who smoke want to quit, many find it difficult to do so permanently. Nicotine patches and gum are safe, effective and widely used methods to help individuals quit. E-cigarettes heat liquids with nicotine and flavourings, allowing users to 'vape' nicotine instead of smoking. Data from the review showed that if six in 100 people quit by using nicotine replacement therapy, eight to twelve would quit by using electronic cigarettes containing nicotine. This means an additional two to six people in 100 could potentially quit smoking with nicotine containing electronic cigarettes. For more information on the full Cochrane review updated in September 2021 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub7/full or our webpage https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 This podcast is supported by Cancer Research UK.

A new research paper was published in Aging (listed as “Aging (Albany NY)” by MEDLINE/PubMed and “Aging-US” by Web of Science) Volume 14, Issue 17, entitled, “Probiotics treatment for Parkinson disease: a systematic review and meta-analysis of clinical trials.” People with Parkinson's disease (PwP) exhibit gut dysbiosis and considerable gastrointestinal (GI) symptoms. Probiotics, beneficial strains of microorganisms, and supplements optimize the intestinal environment and alleviate GI symptoms among elderly people. In a new study, researchers Chien-Tai Hong, Jia-Hung Chen and Tsai-Wei Huang from Taipei Medical University conducted a systematic review and meta-analysis of clinical trials to investigate the effects of probiotics on people with Parkinson's disease. PubMed, Embase and Cochrane Library databases were used. Six randomized controlled trials (RCTs) and two open-label studies were included. Most of the probiotic regimens were based on Lactobacillus and Bifidobacterium. Six studies investigated the benefit of probiotics for GI symptoms, especially for PwP with functional constipation, and two RCTs assessed probiotics' effect on systematic metabolism and inflammation. Major outcomes were the effects of probiotics on GI symptoms, including bowel movement and stool characteristics. “In the meta-analysis, probiotic treatment significantly increased the frequency of bowel movements among PwP (mean difference [MD]: 1.06 /week, 95% confidence interval [CI]: 0.61 to 1.51, p < 0.001, I2 = 40%). Additionally, probiotic treatment significantly normalized stool consistency (standard MD: 0.61, 95% CI = 0.31 to 0.91, p < 0.001, I2 = 0%).” Although the probiotic compositions varied, the researchers found that probiotic treatment significantly attenuated constipation for people with Parkinson's disease and exhibited possible systematic effects on inflammation and metabolism. Given the tolerability of probiotics, the present meta-analysis may provide more consolidated evidence of the benefit of probiotics on constipation in people with Parkinson's disease and a possible new therapeutic approach for disease modification. “This review and meta-analysis determined that probiotic treatments, mainly Lactobacilli and Bifidobacterium–based regimens, effectively alleviated constipation. Adverse effects are generally tolerable. However, considering the gut microbiota is highly associated with a person's environment and diet, studies from other continents are required to establish the benefit of probiotics on constipation. Moreover, probiotic treatment is likely to affect the systemic inflammation and metabolism of PwP, but further studies are warranted to investigate the possibility of the disease modification effect on PD.” DOI: https://doi.org/10.18632/aging.204266 Corresponding Author: Tsai-Wei Huang – Email: tsaiwei@tmu.edu.tw About Aging-US: Launched in 2009, Aging (Aging-US) publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at www.Aging-US.com​​ and connect with us: SoundCloud – https://soundcloud.com/Aging-Us Facebook – https://www.facebook.com/AgingUS/ Twitter – https://twitter.com/AgingJrnl Instagram – https://www.instagram.com/agingjrnl/ YouTube – https://www.youtube.com/agingus​ LinkedIn – https://www.linkedin.com/company/aging/ Reddit – https://www.reddit.com/user/AgingUS Pinterest – https://www.pinterest.com/AgingUS/ For media inquiries, please contact media@impactjournals.com

This week, please join author Kory Lavine and Associate Editor Thomas Eschenhagen as they discuss the article "Donor Macrophages Modulate Rejection After Heart Transplantation." Dr. Carolyn Lam:             Welcome to Circulation on the Run, your weekly podcast summary and backstage pass to the journal and its editors. We're your co-hosts. I'm Dr Carolyn Lam, associate editor from the National Heart Center and Duke National University of Singapore. Dr. Greg Hundley:           I'm Dr. Greg Hundley, associate editor and director of the Pauley Heart Center at VCU Health in Richmond, Virginia. Well, Carolyn, this week's feature, we are going to the world of preclinical science and we are going to learn about a very important new finding pertaining to heart transplant rejection, and macrophages may modulate this, but before we get to that feature, how about we grab a cup of coffee and go through some of the other articles in the issue? Dr. Carolyn Lam:             I got mine. Would you like to go first, Greg? Dr. Greg Hundley:           You bet, Carolyn. Well, my first study comes to us from Dr. Michael Pencino from Duke University. Carolyn, this study was performed to understand the predictive utility of a previously derived polygenic risk score for long-term risk of coronary heart disease and its additive value beyond traditional risk factors and how that might be able to inform prevention strategies. To accomplish this, data from adults aged 20 to 59 free of cardiovascular health disease from the Framingham Offspring Study and the Atherosclerosis Risk in Communities, or ARIC Study, were analyzed. Now, since the polygenic risk score was derived from people of predominantly European ancestry, individuals who self-reported white race were those that were included. Dr. Carolyn Lam:             Oh, interesting, so what did they find, Greg? Dr. Greg Hundley:           Right, Carolyn. Somewhat surprisingly, they found that, among 9,757 participants, both the traditional risk factor score and the polygenic risk score where significantly associated with incident cardiovascular heart disease in young, early midlife, and late midlife. Now, the delta C index, when the polygenic risk score was added to the traditional risk factor, score was 0.03, 0.02, and 0.002 in the young, the early midlife, and the late-midlife participants, respectively. Carolyn, despite a statistically significant association between the polygenic risk score and the 30-year risk of cardiovascular heart disease, the C index improved only marginally with the addition of the polygenic risk score to the traditional risk factor model among young adults and did not improve among midlife adults and, thus, Carolyn, the polygenic risk score, an immutable factor, has limited clinical utility for long-term cardiovascular heart disease prediction when added to a traditional risk factor model. Dr. Carolyn Lam:             I really like that, Greg, because I think it also tells us that the traditional risk factors, which we can do something about, are still very important. Isn't that great? Well, the next paper is about POTS. Remember what that is? Should I give you a quiz? All right. It's okay. POTS, or Postural Orthostatic Tachycardia Syndrome, is a disorder of orthostatic intolerance that primarily affects females of childbearing age. While the underlying pathophysiology of POTS is not fully understood, it has been suggested that autoimmunity may play a role. Now, the aim of this study was to compare concentrations of autoantibodies to cardiovascular G protein-coupled receptors between 116 POTS patients and 81 healthy controls, and they were from Calgary, Canada, and Malmo, Sweden. Dr. Greg Hundley:           Carolyn, really interesting, so what did they find here? Dr. Carolyn Lam:             The investigators, led by Dr. Raj from University of Calgary in Canada, found that commercially available autoantibody concentrations to G protein-coupled receptors were not increased or altered in POTS patients relative to healthy controls as assessed using ELISA. Now, while this study suggests that these G protein-coupled receptor autoantibody concentrations alone cannot explain the pathophysiology of POTS, autoantibody activity and signals not picked up by ELISA should still be explored as these results may provide more insights into the pathophysiology of POTS. Dr. Greg Hundley:           Very nice, Carolyn. Well, my next study comes to us from the world of pulmonary arterial hypertension. Carolyn, clinical worsening is commonly used as an endpoint in pulmonary arterial hypertension trials. These authors, led by Dr. Steeve Provencher from the Institut Universitaire de Cardiologie Pneumologie de Quebec, aimed to assess the trial-level surrogacy of clinical worsening for mortality in pulmonary artery hypertension trials and whether the various clinical worsening components were similar in terms of frequency of occurrence, treatment-related relative risk reduction and importance to patients. Dr. Carolyn Lam:             Okay, so what did they find? Dr. Greg Hundley:           Right, Carolyn, so they searched MEDLINE, Embase and the Cochrane Library for trials evaluating the effects of pulmonary arterial hypertension on clinical worsening and, among 35 independent cohorts, so 9,450 patients, the effects of pulmonary arterial hypertension-specific therapies on clinical worsening modestly correlated with mortality. Additionally, study-level clinical worsening was not found to be a surrogate for mortality in pulmonary arterial-hypertension trials. Moreover, components of clinical worsening largely vary in frequency, response to therapy and importance to patients and, thus, are not necessarily interchangeable. Dr. Carolyn Lam:             Thank you, Greg. Can I tell you about some other papers in today's issue? There's a Research Letter from Dr. Cosentino on cardiorenal outcomes with ertugliflozin by baseline metformin use, and this is a post hoc analysis of the VERTIS CV trial. Dr. Greg Hundley:           Oh, very good, Carolyn. Well, I've got an exchange of letters from Professors Boriani and Steinberg regarding the article “Driving Restrictions and Early Arrhythmias in Patients Receiving a Secondary Prevention Implantable Cardioverter-Defibrillator, the DREAM-ICD-II Study.” There's also an ECG Challenge from Professor Gao entitled “Syncope in a 3-Year-Old Child During the Perioperative Period. What is the diagnosis? What Signs Point Toward Impending Life-threatening Event?” Then, finally, there's a nice, On My Mind piece from Professor Greenland entitled “Insurance Payers Should Cover Selective Coronary Artery Calcium Testing in Intermediate Risk Primary Prevention Patients.” Well, Carolyn, how about we get on to that feature discussion and dive into the world of rejection after heart transplantation? Dr. Carolyn Lam:             Yay. Here we go. Dr. Greg Hundley:           Welcome, listeners, to this feature discussion on August 23rd. We have a very interesting article today to discuss with our author and associate editor pertaining to preclinical science and cardiac transplant rejection. Our author today is Dr. Kory Lavine from Washington University in St. Louis and our associate editor today is Dr. Thomas Eschenhagen from Hamburg, Germany. Welcome gentlemen. Kory, we'll start with you. Can you describe for us some of the background information pertaining to the construct of your study and what was the hypothesis that you wanted to address? Dr. Kory Lavine:               Well, thank you for having me. Our study focused on heart transplant rejection, which remains a major clinical challenge that limits both the survival of heart transplant recipients as well as availability of donor hearts. Current clinical practice really focuses on suppressing the immune system in a global way, and that is somewhat effective, but carries important risks that include infection and life-threatening malignancies. Many studies have appropriately focused on immune cells that infiltrate the transplanted heart that come from the recipient to search for new ways to suppress the immune system safely. What we've understood and learned over the past several years is that the donor heart has its own immune system and its own immune cells, and the majority of those immune cells that come with the donor heart are macrophages that can be broadly divided into two distinct lineages with different functions, tissue-resident macrophages, which lack the cell surface receptors CCR2, and monocyte-derived macrophages with expressed cell surface receptors CCR2. We tested the hypothesis in this study that these macrophages that come with the donor heart remain active for a period of time after transplantation and play important roles in either suppressing or accelerating heart transplant rejection. Dr. Greg Hundley:           What was the hypothesis that you wanted to address with your study? Dr. Kory Lavine:               Yeah, so our prior work and others' work within this field had suggested that tissue-resident macrophages, CCR2-negative macrophages, are inflammatory, and CCR2-positive macrophages have the opposite functions being inflammatory and play roles in potentiating and initiating inflammation in the heart. In this study, we hypothesized that CCR2-negative macrophages would protect from rejection, while CCR2-positive macrophages may promote heart transplant rejection and could serve as a new therapeutic target to prevent rejection in transplant recipients. Dr. Greg Hundley:           Excellent. Kory, can you describe for us the study design that you used to test your hypothesis? Dr. Kory Lavine:               Yeah. The study design and approach we used involved a mouse model of heart transplantation where we transplant a donor heart into a recipient mouse that's fully mismatched at all the MHC loci, and this serves as a nice model for both cellular and antibody-mediated rejection. To facilitate tracking these donor macrophages, we used various genetic lineage tracing systems and, to study their phenotypes, we used single-cell RNA sequencing and, to understand their function, we used mouse models that allow us to specifically deplete each of the donor macrophage populations as well as genetic models to manipulate their activation and signaling. Dr. Greg Hundley:           The outcome measures were going to be what? Dr. Kory Lavine:               Yeah. The outcome measures for transplant rejection in this mouse model are allograph survival, so the survival of the transplanted heart. We're able to directly look at how much rejection is present by histopathology, and then we're able to observe various mechanistic features using detailed phenotyping such as single-cell RNA sequencing and T-cell activation assays. Dr. Greg Hundley:           Very nice, Kory. Well, all, our listeners, we're very excited to hear what were your study results? Dr. Kory Lavine:               We learned that donor macrophages are dynamic and they survive for a period of time after transplantation or eventually lost due to transplant rejection. When we phenotyped the macrophages that came from the donor heart, we learned that they remained transcriptionally distinct from immune cells that enter the heart that were derived from the recipients, and they had important and distinct functions. If we depleted the tissue-resident macrophages that were CCR2-negative, we observed reduced allograph survival and increased rejection. If we depleted CCR2-positive macrophages that came from the donor heart, we observed improved allograph survival and reduced rejection. Mechanistically, we learned that CCR2-positive macrophages are activated through a MyD88-dependent pathway and, if we inhibited MyD88 cytokines which controls the expression of pro-inflammatory cytokines and chemokines, we could prolong the survival of the donor heart for a very significant period of time, reduce rejection and prevent the development of T-cells that would attack the donor heart. From a mechanistic aspect, what we uncovered is that this signaling pathway in CCR2-positive macrophages regulated the recruitment of an activation of antigen-presenting cells which played important roles in generating T-cells that would target the transplanted heart. Dr. Greg Hundley:           It sounds like a really informative and leap forward in the whole sphere of transplant rejection. Well, listeners, now we're going to turn to our associate editor, Dr. Thomas Eschenhagen. Thomas, you have many papers come across your desk. What attracted you to this particular paper and then, secondly, how do you put the results of this study really in the context of other research examining heart transplant rejection? Dr. Thomas Eschenhagen:           Yeah, thanks for having me. I mean, first, we got attracted by this paper because it's somewhat an out-of-the-box approach. It's not the standard approach to improve the systemic immunosuppression as many studies did and with actually a lot of success over the last 30 years, survivor got much better. There had been a lot of progress in the field of transplantation medicine as we all know, but as Kory said already, we still have 30% rejection, and these immunosuppressions come at a price. Having this study which turns around somehow the argumentation and looks at the donor organ was something which really attracted us. It uses advanced methods and it applies somewhat in a practical way a concept which emerged over the last, I don't know, maybe decade this concept that macrophages are really very different kind of cells. They're all called macrophages, but they're quite different and even maybe in certain respects having opposing effect. I think many people know about this M1/M2 concept. It's CCR2 receptor positive and negative. It's criticized by some people, but here we see that it really seems to be really important and, of course, then the third argument why we really like the story is that it has a specific, clear translation impact. I mean, looking at the heart, the donor heart, and potentially even treating the donor heart before transplanting it is something which comes immediately out of the story, and that's something which we found super attractive. Dr. Greg Hundley:           Really interesting, so really understanding the mechanism and focusing on donor hearts. Well, listeners, let's circle back with Kory. Kory, given that, what do you think is the next study that really needs to be performed in this sphere of research? Dr. Kory Lavine:               I think Thomas said it exactly as we're thinking about it, so the next area that we're really excited to attack and we're hopeful that the field will focus on is ways to build methods and technologies to treat the donor heart between the time of procurement and the time of transplant, when it's being transported and potentially even being perfused for a period of time. We're really interested in finding approaches to identify small molecules and other potential biologic therapies that could be used to prevent the activation of donor CCR2-positive macrophages. It's a really attractive approach because treating the donor heart ex vivo decreases the risk of adversely affecting other organs that may be transplanted if you're treating the donor, for instance, and it may decrease the risk of immunosuppression and infection by not having to treat the recipient and we're catching the heart in this window where the risks are much lower. The other area that we're really excited to focus on is trying to identify the exact mediators that are generated from donor CCR2-positive macrophages that mediate the recruitment and activation of antigen-presenting cells because that would represent another potential therapeutic target. Dr. Greg Hundley:           Very nice. Thomas, what are your thoughts about what might be the next study to be performed really in this sphere of research? Dr. Thomas Eschenhagen: It's obviously something rather a question to Kory than to me, but I agree to what he said. I think it is pretty obvious what are the next steps mechanistically on the one hand, but practically on the other hand. I mean, at this point, we are at the mouse level, so the question is to which extent can this concept be translated into larger animals and then finally in humans? I was wondering, given these newer methods to keep donor hearts alive for long, extended periods, I was wondering which extent you are already collaborating with the respective groups who develop this approach because that obviously would increase the window of opportunity here for drugs. I think it's really an exciting and pretty visible next steps which we see here, and I can just hope that you're going this path and that it will be successful. Dr. Greg Hundley:           Kory, any thoughts on those collaborations that Thomas just spoke of? Dr. Kory Lavine:               We're definitely establishing collaborations to focus on ex vivo profusion of donor hearts because that's, as Thomas mentioned, is a perfect window to manipulate the immune populations that are within the donor heart. Those studies have to be team science, they have to be collaborative and they have to have a focus on large animals and then moving into clinic. We're definitely forming those collaborations and excited to work as a group. Dr. Greg Hundley:           Very nice. Well, listeners, what an exciting paper to discuss here as part of this feature discussion from the world of preclinical science. We want to thank Dr. Kory Lavine from Washington University in St. Louis, Missouri, and also our own associate editor, Dr. Thomas Eschenhagen from Hamburg Germany, for really bringing us this research study highlighting that distinct populations of donor and recipient macrophages coexist within the transplanted heart, and donor CCR2-positive macrophages are key mediators of allograph rejection and deletion of MyD88 signaling in donor macrophages is sufficient to suppress rejection and extend allograph survival. Well, on behalf of Carolyn and myself, we want to wish you a great week, and we will catch you next week on the run. Dr. Greg Hundley:           This program is copyright of the American Heart association, 2022. The opinions expressed by the speakers in this podcast are their own and not necessarily those of the editors or of the American Heart Association. For more, please visit ahajournals.org.

The Cochrane Pain, Palliative and Supportive Care Group has more than 270 active full reviews in the Cochrane Library. They added to these in May 2022 with a new review of the effects of giving antiemetics to adults receiving intravenous opioids in acute care. We asked lead author, Michael Gottlieb from the Department of Emergency Medicine at Rush University Medical Center in Chicago, USA, to tell us more in this podcast.

The Cochrane Pain, Palliative and Supportive Care Group has more than 270 active full reviews in the Cochrane Library. They added to these in May 2022 with a new review of the effects of giving antiemetics to adults receiving intravenous opioids in acute care. We asked lead author, Michael Gottlieb from the Department of Emergency Medicine at Rush University Medical Center in Chicago, USA, to tell us more in this podcast.

Neste episódio, vou mostrar para vocês o resultado de mais uma revisão sistemática da Cochrane de dezembro de 2020, demonstrando os efeitos da acupuntura no tratamento da dor lombar não específica. Após, vou falar a vocês um pouco sobre viés de publicação, através de como interpretar o gráfico em funil, orientado a ser apresentado nas revisões sistemáticas. Artigo disponível em Acupuncture for chronic nonspecific low back pain - Mu, J - 2020 | Cochrane Library

Este episódio vai discutir os resultados de uma revisão sistemática Cochrane de 2020, onde pesquisadores revisaram a literatura sobre os efeitos do uso dos corticóides no tratamento da dor de garganta. Também vou conversar um pouco sobre as definições das medidas de efeito Risco Relativo e Taxa de Risco. Artigo disponível em Corticosteroids as standalone or add‐on treatment for sore throat - de Cassan, S - 2020 | Cochrane Library

Portion sizes have increased over the years, and food is more convenient than ever. And when our environment is filled with an abundance of food, it can be hard to say no, especially for a dieter who feels restricted and deprived. In a 2015 review of 72 studies published by the Cochrane Library, it says, “Research consistently shows that when we're presented with a big portion, we eat more—even when we are not hungry.” It's a simple but effective strategy: Serve yourself less food and you'll eat less, and lose weight as a result.  Sounds simple enough, right? But reducing portions is only one piece of the puzzle. Join coach, Laura Kalirai, and myself on today's episode of the Fat Murder Podcast as we dig into the psychological differences between portion control and hunger directed eating. Any ideas on what they may be?  Connect with Leslie: • Website • Instagram • Facebook If you're struggling with emotional, binge, or compulsive eating and you're interested in personalized coaching, apply here. If you want to learn how to not-only lose weight, but lose the struggle along side it, you can get started by taking the Weight Loss Psychology Quiz: Discover Your Diet Personality Type Go to lesliehooper.com for more information about our different coaching packages.

Welcome to Episode 18 of “The 2 View,” the podcast for EM and urgent care nurse practitioners and physician assistants! Show Notes for Episode 18 of “The 2 View” – Acute Infectious Conjunctivitis, Post-Traumatic Patients in the ER: Treatment of the Sexual Assault Survivor, Cops in the ED, and a Very Special Interview. Acute Infectious Conjunctivitis Review & Meta-Analysis Fox SM. Conjunctivitis and Conjunctivitis-Otitis Syndrome. Pediatric EM Morsels. Published February 17, 2012. Accessed June 23, 2022. https://pedemmorsels.com/conjunctivitis-and-conjunctivitis-otitis-syndrome/ Johnson D, Liu D, Simel D. Does This Patient with Acute Infectious Conjunctivitis Have a Bacterial Infection?: The Rational Clinical Examination Systematic Review. The Rational Clinical Examination. JAMA Network. Published June 14, 2022. Accessed June 23, 2022. https://jamanetwork.com/journals/jama/article-abstract/2793248 Prescription prices, coupons & pharmacy information. GoodRx. Accessed June 23, 2022. http://www.goodrx.com Sheikh A, Hurwitz B, van Schayck CP, McLean S, Nurmatov U. Antibiotics versus placebo for acute bacterial conjunctivitis. Cochrane Database Syst Rev. Cochrane Library. Published September 12, 2012. Accessed June 23, 2022. https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD001211.pub3/full Post-Traumatic Patients in the ER: Treatment of the Sexual Assault Survivor Post-Exposure Prophylaxis (PEP). Cdc.gov. Centers for Disease Control and Prevention. Published March 28, 2022. Accessed June 23, 2022. https://www.cdc.gov/hiv/risk/pep/index.html Preventing New HIV infections. Cdc.gov. Centers for Disease Control and Prevention. Published March 29, 2022. Accessed June 23, 2022. https://www.cdc.gov/hiv/guidelines/preventing.html Sexual Assault and Abuse and STIs – Adolescents and Adults – STI Treatment Guidelines. Sexually Transmitted Infections Treatment Guidelines, 2021. Cdc.gov. Centers for Disease Control and Prevention. Published July 14, 2021. Accessed June 23, 2022. https://www.cdc.gov/std/treatment-guidelines/sexual-assault-adults.htm Alcohol and Drug Testing of the Patient in Police Custody Supreme Court Ruling Provides Clarity on Law Enforcement-Requested Blood Draws. Reliasmedia.com. Published January 1, 2020. Accessed June 23, 2022. https://www.reliasmedia.com/articles/145471-supreme-court-ruling-provides-clarity-on-law-enforcement-requested-blood-draws Tessier W, Keegan W. Mandatory Blood Testing: When can police compel a health provider to draw a patient's blood to determine blood levels of alcohol or other intoxicants? Mo Med. PMC PubMed Central. NIH: National Library of Medicine, National Center for Biotechnology Information. Published Jul-Aug 2019. Accessed June 23, 2022. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699816/ Risk Management Monthly featuring W. Richard Bukata MD, Greg Henry MD, and Rachel Lindor MD, JD The Center for Medical Education. Physician Separation Agreements, Lawsuit from Starting IV line, and More | Risk Management Monthly. Published June 7, 2022. Accessed June 23, 2022. https://www.youtube.com/watch?v=6D24mJ5aJ_Y&list=PLlgl86ABpNQweXlLL8sNT19oixAoaTS46 Jim Roberts MD in Emergency Medicine News Roberts J. Looking Back on a Career in Emergency Medicine. InFocus. Emergency Medicine News. Lww.com. Published June 2022. Accessed June 23, 2022. https://journals.lww.com/em-news/fulltext/2022/06000/infocus_lookingbackonacareerin_emergency.8.aspx Recurring Sources Center for Medical Education. Ccme.org. http://ccme.org The Proceduralist. Theproceduralist.org. http://www.theproceduralist.org The Procedural Pause. Emergency Medicine News. Lww.com. https://journals.lww.com/em-news/blog/theproceduralpause/pages/default.aspx The Skeptics Guide to Emergency Medicine. Thesgem.com. http://www.thesgem.com Trivia Question: Send answers to 2viewcast@gmail.com Be sure to keep tuning in for more great prizes and fun trivia questions! Once you hear the question, please email us your guesses at 2viewcast@gmail.com and tell us who you want to give a shout-out to. Be sure to listen in and see what we have to share!

Neste episódio vou apresentar mais uma revisão sistemática da Biblioteca Cochrane, agora falando sobre a eficácia do uso dos anti-inflamatórios no tratamento da dor lombar aguda. Aproveitarei para revisar com vocês alguns dos principais vieses avaliados a fim de classificar a qualidade das evidências. Artigo disponível em Non‐steroidal anti‐inflammatory drugs for acute low back pain - van der Gaag, WH - 2020 | Cochrane Library

Neurodevelopmental Therapy for Cerebral Palsy: A Meta-analysisAnna Te Velde, Catherine Morgan, Megan Finch-Edmondson, Lynda McNamara, Maria McNamara, Madison Claire Badawy Paton, Emma Stanton, Annabel Webb, Nadia Badawi, Iona NovakAbstractBackground and objective: Bobath therapy, or neurodevelopmental therapy (NDT) is widely practiced despite evidence other interventions are more effective in cerebral palsy (CP). The objective is to determine the efficacy of NDT in children and infants with CP or high risk of CP.Methods: Cumulative Index to Nursing and Allied Health Literature, Cochrane Library, Embase, and Medline were searched through March 2021. Randomized controlled trials comparing NDT with any or no intervention were included. Meta-analysis was conducted with standardized mean differences calculated. Quality was assessed by using Cochrane Risk of Bias tool-2 and certainty by using Grading of Recommendations Assessment, Development, and Evaluation.Results: Of 667 records screened, 34 studies (in 35 publications, 1332 participants) met inclusion. Four meta-analyses were conducted assessing motor function. We found no effect between NDT and control (pooled effect size 0.13 [-0.20 to 0.46]), a moderate effect favoring activity-based approaches (0.76 [0.12 to 1.40]) and body function and structures (0.77 [0.19 to 1.35]) over NDT and no effect between higher- and lower-dose NDT (0.32 [-0.11 to 0.75]). A strong recommendation against the use of NDT at any dose was made. Studies were not all Consolidated Standards of Reporting Trials-compliant. NDT versus activity-based comparator had considerable heterogeneity (I2 = 80%) reflecting varied measures.Conclusions: We found that activity-based and body structure and function interventions are more effective than NDT for improving motor function, NDT is no more effective than control, and higher-dose NDT is not more effective than lower-dose. Deimplementation of NDT in CP is required.

James (Jim) Wright obtained his MD from the University of Alberta in 1968, his FRCP(C) in Internal Medicine in 1975 and his Ph.D. in Pharmacology from McGill University in 1976. He is a practicing specialist in Internal Medicine and Clinical Pharmacology. He is also Co-Managing Director of the Therapeutics Initiative, Editor-in-Chief of the Therapeutics Letter and Coordinating Editor of the Cochrane Hypertension Review Group. He sits on the Editorial Boards of PLoS One and the Cochrane Library.Questions We Asked:•How did you become involved with pharmacology and drug prescription? •How would you define appropriate use? •Does financial implications to the patient play into appropriate use? •What do most physicians not know when they prescribe medications? •How does overprescribing play into medical waste?•Why is there a disconnect between systematic reviews and clinical guidelines? •How does bias play into drug testing? •How can we successfully collaborate with pharmaceutical companies without including bias into research? •How do everyday clinicians decide how to treat patients based on guidelines vs systematic reviews? •What makes a good systematic review? •What advice do you have for trainees who want to do good for their patients? •Book Suggestions? Quotes and Ideas:•Appropriate use of medications means that the benefits outweigh the harms of the medication •Every time a patient takes a medication, they are reminded of their medical condition that needs treatment. •Many psychiatric medications get onto market only due to short term medical trials, but many are prescribed for long term conditions. •Leaders should push for non-industry funded trials that evaluate the long term effectiveness of medications. •ALLHAT trial as an effectively run drug testing study  •We don't want a situation where marketing is the driving force and not research •Choosing Wisely Campaign Book Suggestions: •Sickening by John Abramson •Our Daily Meds by Melody Petersen •Anatomy of an Epidemic by Robert Whitakers  

Neste episódio vou comentar uma revisão sistemática publicada na Cochrane Library em maio de 2020, falando sobre os efeitos da redução de gordura saturada na dieta e sua relação com mortalidade por todas as causas ou por doenças cardiovasculares. Também vou falar sobre diferença entre mortalidade específica e mortalidade por todas as causas. Artigo disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388853/

Robert Yoho calls himself a healthcare whistleblower. He practiced medicine in the United States and retired two years ago. He spent three decades as a cosmetic surgeon after a career as an emergency physician. This generalist training gave him perspective and allowed him to avoid favoring any medical specialty. Robert has recently published two books, Butchered by Healthcare and Hormone Secrets. He has had little dealings with hospitals, Big Pharma, or insurance companies before he wrote his books. No one has ever considered him a "whale" prescriber or device implanter. A few highlights from the show: 1. There is now one pharmaceutical sales representative for every five doctors in the US. They call the big prescribers who like and use their drugs “whales.” 2. Per Robert. How to stay healthy: (a) change your diet to a higher fat diet, (b) learn about and practice controlled fasting, (c) cut carbohydrates (simple sugars and corn sugar). 3. Having an advocate is key when navigating the healthcare system. It is ok to change your doctor if you are not feeling better. 4. Things 3 iPhone app for help getting organized. - https://apps.apple.com/us/app/things-3/id904237743 5. Visit the Cochrane Library to review evidence to inform healthcare decision-making. - https://www.cochranelibrary.com/ Follow and learn more about Robert and the healthcare system at: https://www.robertyohoauthor.com/ Butchered by Healthcare audiobook: https://www.youtube.com/watch?v=Ye476jKeDMw Hormone Secrets audiobook: https://www.youtube.com/watch?v=WmDCYOSa1w8 Surviving Healthcare podcast: https://www.buzzsprout.com/1718994 About Me: In 2011, I was diagnosed with Hodgkin's Lymphoma, out of the blue. I did not have any prior health concerns or issues. Fast forward, the dreaded cancer diagnosis opened my eyes, introduced me to my purpose, and lead me to where I am today. As a Cancer Doula, I use my 10-years of experience with cancer to support and guide others diagnosed with cancer. Many people are not familiar with what a cancer doula is. Think of me as a personal health care advocate. Schedule a free 30-minute meet and greet call to learn more. https://bit.ly/OTOSDiscovery Looking for a gift for yourself, a friend, or a loved one who has been diagnosed with cancer or they are a caregiver? Visit my shop. Thanks for joining us on today's episode of the Navigating Cancer TOGETHER podcast! If you enjoyed today's episode, please head over to iTunes and leave a rate and review to help me reach even more people that are facing cancer. Make sure you visit On the Other Side, follow me on Instagram, or sign up for my bi-weekly newsletter to get information and resources related to cancer. --- Send in a voice message: https://anchor.fm/navigatingcancertogether/message Support this podcast: https://anchor.fm/navigatingcancertogether/support

Today I welcome on my friend and colleague Dr. Joshua Goldenberg to speak about Evidence based practice within the Naturopathic Medicine profession and more specifically when it comes to Irritable Bowel Syndrome (IBS) and Small Intestinal Bacterial Overgrowth (SIBO) Dr. Goldenberg is a shining star in the naturopathic medicine research space especially known for his work in helping push forward research in the IBS and SIBO realm. You can find his work at Goldenberg GI Center. and all of Pubmed by searching for Joshua Goldenberg. We got together to discuss the landscape of research in naturopathic medicine specifically related to IBS and SIBO. Please see below for the show outline Please note: We will donate $100 for the first 100 plays to Hydrogens Sulfide SIBO Research Study. Please join me by going to https://www.gofundme.com/f/hydrogen-sulfide-sibo-registry-study to support this worthy cause (00:00) show opening (02:00) Route to Naturopathic Medicine. From Molecular Biology at Penn to Naturopathic Medicine. (07:29) Covid-19 impact on his research (11:40) IBS Naturopathic Research Overview (15:57) Reading Naturopathic Research (21:56) Dysbiosis Research (24:20) Power of Placebo in IBS (28:48) Key variables in IBS research (29:38) Absolute effect/Absolute Risk reduction (34:36) Science vs. Skepticism (39:39) Closing About Dr. Goldenberg Dr. Goldenberg is a researcher, teacher, naturopathic doctor and founder of Dr. Journal Club, LLC. He is most passionate about the interplay of evidence and clinical practice. Dr. Goldenberg is an active researcher with numerous publications in high impact scientific journals such as JAMA, Annals of Internal Medicine and The Cochrane Library. His research focus includes irritable bowel syndrome, probiotics, evidence-informed practice, and research methodology. He is Research Investigator at the Helfgott Research Institute and Visiting Research Scholar at the University of Technology Sydney. o Dr. Goldenberg is a passionate educator and is faculty for the Academy of Integrative Health and Medicine's Interprofessional Fellowship in Integrative Health and Medicine. He is past adjunct faculty at Bastyr University, his alma mater, in which he enrolled after receiving honors and distinction in molecular biology from the University of Pennsylvania. As a naturopathic doctor Dr. Goldenberg focuses on integrative approaches to irritable bowel syndrome as well as other gastrointestinal complaints at Goldenberg GI Center. In 2014 Dr. Goldenberg created the medical education website www.DrJournalClub.com in order to share his passion for the interplay of evidence and clinical practice with the larger integrative medicine community. • Resources and Links from the episode: Dr. Goldenberg's Research https://pubmed.ncbi.nlm.nih.gov/?term=joshua+goldenberg Goldenberg GI center https://goldenberggicenter.com/dr-goldenberg/ World Naturopathic Federation Research paper on Covid-19 https://worldnaturopathicfederation.org/wp-content/uploads/2021/12/White-Paper.pdf Zinc for the prevention or treatment of acute viral respiratory tract infections in adults: a rapid systematic review and meta-analysis of randomized controlled trials https://bmjopen.bmj.com/content/11/11/e047474 2018 Ted Kaptchuk. open label placebo https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889847/ --- Send in a voice message: https://anchor.fm/adam-rinde/message

Chronic low back pain is a very common health problem and there are many relevant reviews in the Cochrane Library. A new review, of nearly 250 studies of the effects of exercise, was added to the Library in September 2021. Toby Lasserson, Deputy Editor in Chief of the Library spoke with lead author, Jill Hayden from Dalhousie University in Halifax, Canada about the review and its findings.

Chronic low back pain is a very common health problem and there are many relevant reviews in the Cochrane Library. A new review, of nearly 250 studies of the effects of exercise, was added to the Library in September 2021. Toby Lasserson, Deputy Editor in Chief of the Library spoke with lead author, Jill Hayden from Dalhousie University in Halifax, Canada about the review and its findings.

1. Dabei sein ist alles … Da-Sein als nicht-pharmakologische Therapie Cochrane Deutschland & Cochrane Library: https://www.cochrane.de/de 2. Kritisches Glossar - Empowerment Originalbeitrag: https://www.dzla.de/empowerment-fuer-menschen-mit-demenz/ 3. "Father" - eine Filmkritik Originalbeitrag: https://www.dzla.de/the-father-filmkritik/ 4. Kritisches Glossar - Einsamkeit Originalbeitrag: https://www.dzla.de/einsamkeit/ 5. Neues aus dem DZLA & der DialogAkademie Dialogzentrum Leben im Alter (DZLA) Blog: http://www.dzla.de Facebook: https://www.facebook.com/dialogDZLA Twitter: https://twitter.com/DZLA_HSO Youtube: https://www.youtube.com/channel/UCmizhGiwYw2WuWTPf-xfCLw Abonnieren Sie unsere (Forschungs-)Newsletter unter: https://dzla.de/forschungsnewsletter-des-dzla/ Folge direkt herunterladen

Join Colm, Professor Assumpta Ryan and Professor Faith Gibson in their discussion of the meaning and best practice implementation of reminiscence and life story work in dementia care.Professor Assumpta Ryan is the Professor of Ageing and Health at Ulster University. In this episode she refers to the success of her app ‘The InspireD Reminiscence App' .Professor Faith Gibson is a friend and colleague of Colm, who has informed much of the work of HammondCare's Dementia Centre . A social worker by training, Faith is a pioneer in the field of reminiscence and life story work. Her most recent publication 'International Perspectives on Reminiscence, Life Review and Life Story Work' and earlier work 'Reminiscence and Life Story Work. A Practice Guide' are informative and instructional resources on reminiscence work.  Together, Colm, Faith and Assumpta provide insight, guidance and shared experience to this episode.The Cochrane Library's 1998, 2005 and current 2018 review 'Reminiscence therapy for dementia'   displays over time, how  memories and past experiences with other people using tangible prompts evokes memories and stimulate conversation for those living with dementia.'International Journey of Reminiscence and Life Review' publishes original work exploring the nature, function, and application of remembering the personal past within a wide range of research contexts and practice settings.. The  European Reminiscence Network and American International Center for Life Story Innovations and Practise promote best practice in reminiscence work and to share experience across national frontiers.

Do you avoid going to the beach or the pool because of the way you look in swimwear? For decades we've been made to feel ashamed of our bodies. We've been told to hide our wobbly bits, defuzz our hairy bits, and conceal our pink bits. Body confidence is something many of us struggle with and as a result the summer months are a major source of anxiety. Getting your kit off and being seen in your swimmers can be terrifying. Gab and Sarah share their tips for overcoming your “beach body” fears and embracing a summer full of fun in the water with the people you love most. Subscribe to the Women Like You newsletter here Contact us:womenlikeyoupodcast@gmail.com WLY resources and recommendations: Sarah's Burpees for Boobs Sydney Breast Cancer Foundation fundraiser Cochrane Library: Beach body ready? Shredding for summer? A first look at "seasonal body image" Speedo Womens Spirit Turbo Suit One Piece Une Piece Original Sexie Rashie WLY Spotify playlist The Women Like You podcast is recorded on the lands of the Gadigal people of the Eora nation. We pay our respects to elders past, present and emerging. We acknowledge Aboriginal and Torres Strait Islander peoples as the First Australians and Traditional Custodians of the land where we live, work, and exercise. See omnystudio.com/listener for privacy information.

Walking is a brilliant form of exercise but it's often overlooked in favour of running or yoga or HIIT workouts. Because we are exercise sloths and busy women, we're always looking for quick and easy ways to get moving. If you're trying to get fit and healthy, walking is one of the most accessible types of exercise you can do. Gab and Sarah look at some good quality research which shows why walking is really, really good for you. Don't forget to subscribe to the Women Like You newsletter. To be added to the mailing list, email womenlikeyoupodcast@gmail.com  WLY resources and recommendations: Sarah's Burpees for Boobs Sydney Breast Cancer Foundation fundraiser Walking for hypertension Association of Step Volume and Intensity With All-Cause Mortality in Older Women Kathy Smith power walking audio workout Waking Up with Sam Harris Heavyweight podcast WLY Spotify playlist The Women Like You podcast is recorded on the lands of the Gadigal people of the Eora nation. We pay our respects to elders past, present and emerging. We acknowledge Aboriginal and Torres Strait Islander peoples as the First Australians and Traditional Custodians of the land where we live, work, and exercise. See omnystudio.com/listener for privacy information.

Have you ever tried Pilates? It's a popular form of exercise that was developed by Joseph Pilates in the early 20th century.  It's now a worldwide fitness trend and it's often used as a form of rehabilitation for lower back pain or injury, and recovery after childbirth.  Gab and Sarah look at what Pilates actually involves and if it lives up to the hype. Plus, another batshit crazy fitness trend, this time involving Kate Hudson and a bag full of water.  Don't forget to subscribe to the Women Like You newsletter. To be added to the mailing list, email womenlikeyoupodcast@gmail.com  WLY resources and recommendations: Cochrane Library Pilates for low back pain Jessica Valant - Gentle Pilates 15 Minute Pilates for Beginners Workout WLY Spotify playlist The Women Like You podcast is recorded on the lands of the Gadigal people of the Eora nation. We pay our respects to elders past, present and emerging. We acknowledge Aboriginal and Torres Strait Islander peoples as the First Australians and Traditional Custodians of the land where we live, work, and exercise. See omnystudio.com/listener for privacy information.

Hey Everybody! This ones a barn burner! RCTs, near-death experiences, vitalism vs. materialism, bad New Age experiences... we go to all the places! Carol and I don't always agree, but we love talking about the possibilities and you're going to enjoy listening. Extensive show notes on this one! Carol M. Davis, DPT, EdD,MS, FAPTA is Professor Emerita and immediate past Vice Chair of the Department of Physical Therapy at the University of Miami Miller School of Medicine in Miami Florida. She is also a manual therapist in active clinical practice, primarily treating patients with cervical and lumbar spine pain utilizing energy-based manual therapy, myofascial release, along with exercise. Dr. Davis is an international lecturer and consultant and a respected author in rehabilitation literature. She is the author of Complementary Therapies in Rehabilitation, and Patient-Practitioner Interaction, both published by Slack Books, Inc., and several text book chapters, many focusing on the science of energy medicine and complementary therapies. She has published over 30 articles in peer reviewed journals. Her areas of scholarly interest include educating students in the affective domain, particularly in professional interactions in health care, ethics, empathy , and using the self as a therapeutic presence with patients. In addition she is interested in reading and translating for broad understanding the essentials of quantum physics and how sub atomic particles affect our physiology and cellular function. Dr. Davis has traveled to several countries as a consultant in these two main areas of her interest, and has received many honors. She has been recognized by the American Physical Therapy Association as a Catherine Worthingham Fellow – the highest honor that a physical therapist can receive by this professional organization. Links Intravenous laser blood irradiation with the Weberneedle® Endo Laser A New Definition of Pain: Update and Implications for Physical Therapist Practice and Rehabilitation Science The Levels of Evidence and their role in Evidence-Based Medicine A re-analysis of the Cochrane Library data: the dangers of unobserved heterogeneity in meta-analyses Sustained release myofascial release as treatment for a patient with complications of rheumatoid arthritis and collagenous colitis: a case report --- Send in a voice message: https://anchor.fm/david-lesondak/message

The Cochrane Library contains more than 140 Cochrane Reviews of the accuracy of diagnostic tests, covering a very wide range of conditions. One of these reviews, on a test used to detect tuberculosis in the lungs, was updated for the third time in February 2021 and Karen Steingart from the Liverpool School of Tropical Medicine in the UK speaks with first author, Jerry Zifodya from Tulane University in New Orleans, USA about the latest findings in this podcast. This review is also included in the Cochrane Library Special Collection for World Tuberculosis Day on 'Diagnosing tuberculosis'.

The Cochrane Library contains more than 140 Cochrane Reviews of the accuracy of diagnostic tests, covering a very wide range of conditions. One of these reviews, on a test used to detect tuberculosis in the lungs, was updated for the third time in February 2021 and Karen Steingart from the Liverpool School of Tropical Medicine in the UK speaks with first author, Jerry Zifodya from Tulane University in New Orleans, USA about the latest findings in this podcast. This review is also included in the Cochrane Library Special Collection for World Tuberculosis Day on 'Diagnosing tuberculosis'.

Auch die Weltenbummlerin Doris Dörrie verbringt die Pandemie im Homeoffice – und schreibt und schreibt und schreibt. Ihre Inspirationen für kreatives, autobiografisches Schreiben haben eine wachsende Fangemeinde. Im ZEIT-WISSEN-Interview spricht Dörrie über die “narrative Erschöpfung” durch Streamen und Scrollen. Sie erklärt, wie man die Angst vor dem leeren Blatt überwindet – und warum der Schlafanzug beim Schreiben die beste Arbeitskleidung ist. Außerdem (15:37): Hilft Yoga gegen Asthma? Hella Kemper berichtet von ihrem mühsamen Weg, freier atmen zu können, und wir schauen uns den Stand der Forschung in Sachen Yoga und Asthma an. Shownotes: Ein kostenloses Probeheft von ZEIT WISSEN erhalten Sie unter www.zeit.de/zw-aktuell Der Instagram-Kanal von Doris Dörrie: instagram.de/doris_doerrie Ihre "Einladung zum Schreiben" ist bei Diogenes erschienen, ebenso ihr Buch "Leben, Schreiben, Atmen". Die Metastudie zur Wirkung von Yoga bei Asthma ist in der Cochrane Library erschienen: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010346.pub2

Chaga mushrooms, a natural way to regrow hair?  Tokushima University (Japan), February 28 2021 Alopecia areata is a condition characterized by hair falling out in patches. Research suggests it is caused by the immune system attacking the hair follicles, causing them to shrink and slow down hair production. Because of this, alopecia is called an autoimmune disorder. According to statistics, alopecia is a common autoimmune disorder that affects about 6.8 million people in the U.S. alone. One in five people who suffer from alopecia has a family member with the same condition. Hair loss, however, can vary from nothing more than a few patches to complete loss of hair on the scalp or the entire body. There are currently no mainstream cures for alopecia, and the reason why the immune system attacks hair follicles is still unknown. But in a recent study, researchers at Tokushima University in Japan reported a natural medicine that can potentially reverse the effects of alopecia. Inonotus obliquus, commonly known as chaga, is a parasitic fungus that grows on birch and other trees. It is traditionally used to treat gastrointestinal diseases as well as to maintain healthy hair in many countries in Asia. The researchers screened chaga mushrooms for useful phytochemicals and found that it contains plenty of potential anti-alopecia agents. They discussed their findings in detail in an article published in the Journal of Natural Medicines. Compounds in chaga mushroom promote proliferation of hair follicles Chaga mushrooms refer to the resting body, or sclerotium, of I. obliquus. In countries like China, Korea, Japan and Russia, these mushrooms are known for their favorable effects on lipid metabolism and cardiac function. Research has also found that they possess antibacterial, anti-inflammatory, antioxidant and anti-tumor properties, and even exhibit antiviral properties against the hepatitis C virus and the human immunodeficiency virus. On the other hand, phytochemical analysis of chaga mushrooms reveal that they are rich in polysaccharides, triterpenes and polyphenols. They also contain two components commonly derived from birch trees, namely, betulin (or betulinol) and betulinic acid. Studies show that betulin can help lower cholesterol levels and increase insulin sensitivityin mice, while betulinic acid can activate signaling pathways that lead to cancer cell death. According to Japanese researchers, chaga mushrooms are used in Mongolia to make shampoo that helps with the maintenance of strong, healthy hair. This prompted them to investigate whether chaga mushrooms can be used for the treatment of alopecia. Bioassay-guided fractionation of chaga mushroom extracts allowed them to identify five lanostane-type triterpenes whose structures they confirmed using spectroscopy. The researchers then conducted proliferation assays using human follicle dermal papilla cells (HFDPCs) and found that four of the five triterpenes can promote the proliferation of HFDPCs. The compounds were identified as lanosterol, inotodiol, lanost-8,24-diene-3B,21-diol and trametenolic acid. The researchers also reported that these lanostane-type triterpenes were more potent than minoxidil, a conventional treatment for male-pattern baldness that’s used to promote hair growth. Based on these findings, the researchers concluded that the lanostane-type triterpenes in chaga mushrooms are potent anti-alopecia agents that can be used to stimulate hair growth naturally.      Association of serum folate, vitamin A and vitamin C levels with greater bone mineral density Tiajin Fifth Central Hospital (China), February 22, 20221 According to news originating from the Tianjin Fifth Central Hospital research stated, “The conclusions on the associations of specific vitamin levels with bone mineral density (BMD) were controversial. Therefore, the aims of this study were to examine the associations of serum vitamins levels with BMD and the modified effect of race/ ethnicity on these associations in the US adults.” The news editors obtained a quote from the research from Tianjin Fifth Central Hospital: “This study was from the third National Health and Nutrition Examination Survey. All participants aged 18 years with complete data were eligible. Serum vitamins A, B9, B12, C, and E levels were assayed using the Quantaphase II Radioassay Kit (Bio-Rad). Dual-energy X-ray absorptiometry was employed to measure BMD, including femur neck and the total hip. There were 6023 participants included in the final analysis. Serum folate, vitamins A and C levels were positively associated with BMD. No significant associations of serum vitamins B12 and E levels with BMD were observed. There were positive associations of serum folate level (b = 0.00027 and 0.00032; and 95% CI: 0.00002-0.00057 and 0.00002-0.00063, respectively), vitamin A level (b = 0.01132 and 0.01115; and 95% CI: 0.00478-0.01787 and 0.00430-0.01799, respectively), and vitamin C level (b = 0.00027 and 0.00029; and 95% CI: 0.00012-0.00042 and 0.00013-0.00045, respectively) with BMD at femur neck and the total hip only in the Not Hispanic participants.” According to the news editors, the research concluded: “Elevated serum folate, vitamins A and C levels were associated with a higher BMD. Furthermore, sex and race/ ethnicity modified the associations of serum vitamins levels with BMD.”     Study shows mother's diet may boost immune systems of premature infants Johns Hopkins University, February 25, 2021 Medical researchers have long understood that a pregnant mother's diet has a profound impact on her developing fetus's immune system and that babies -- especially those born prematurely -- who are fed breast milk have a more robust ability to fight disease, suggesting that even after childbirth, a mother's diet matters. However, the biological mechanisms underlying these connections have remained unclear. Now, in a study published Feb. 15, 2021, in the journal Nature Communications, a Johns Hopkins Medicine research team reports that pregnant mice fed a diet rich in a molecule found abundantly in cruciferous vegetables -- such as broccoli, Brussels sprouts and cauliflower -- gave birth to pups with stronger protection against necrotizing enterocolitis (NEC). NEC is a dangerous inflammatory condition that destroys a newborn's intestinal lining, making it one of the leading causes of mortality in premature infants. The team also found that breast milk from these mothers continued to confer immunity against NEC in their offspring.  Seen in as many as 12% of newborn babies weighing less than 3.5 pounds at birth, NEC is a rapidly progressing gastrointestinal emergency in which normally harmless gut bacteria invade the underdeveloped wall of the premature infant's colon, causing inflammation that can ultimately destroy healthy tissue at the site. If enough cells become necrotic (die) so that a hole is created in the intestinal wall, the bacteria can enter the bloodstream and cause life-threatening sepsis. In earlier mouse studies, researchers at Johns Hopkins Medicine showed that NEC results when the underdeveloped intestinal lining in premature infants produces higher-than-normal amounts of a protein called toll-like receptor 4 (TLR4). TLR4 in full-term babies binds with bacteria in the gut and helps keep the microbes in check. However, in premature infants, TLR4 can act like an immune system switch, with excess amounts of the protein mistakenly directing the body's defense mechanism against disease to attack the intestinal wall instead. "Based on this understanding, we designed our latest study to see if indole-3-carbinole, or I3C for short, a chemical compound common in green leafy vegetables and known to switch off the production of TLR4, could be fed to pregnant mice, get passed to their unborn children and then protect them against NEC after birth," says study senior author David Hackam, M.D., Ph.D., surgeon-in-chief at Johns Hopkins Children's Center and professor of surgery at the Johns Hopkins University School of Medicine. "We also wanted to determine if I3C in breast milk could maintain that protection as the infants grow."  In the first of three experiments, Hackam and his colleagues sought to induce NEC in 7-day old mice, half of which were born from mothers fed I3C derived from broccoli during their pregnancies and half from mothers fed a diet without I3C. They found that those born from mothers given I3C throughout gestation were 50% less likely to develop NEC, even with their immune systems still immature at one week after birth. The second experiment examined whether breast milk with I3C could continue to provide infant mice with protection against NEC. To do this, the researchers used mice genetically bred without the binding site on intestinal cells for I3C known as the aryl hydrocarbon receptor (AHR). When AHR-lacking pups were given breast milk from mice fed a diet containing I3C, they could not process the compound. Therefore, they developed severe NEC 50% more frequently than infant mice that had the I3C receptor.  The researchers say this shows in mice -- and suggests in humans -- that AHR must be activated to protect babies from NEC and that what a mother eats during breastfeeding -- in this case, I3C -- can impact the ability of her milk to bolster an infant's developing immune system.  In confirmatory studies, Hackam and his colleagues looked at the amounts of AHR in human tissue obtained from infants undergoing surgery for severe NEC. They found significantly lower than normal levels of the receptor, suggesting that reduced AHR predisposes infants to the disease. Finally, the researchers searched for a novel drug that could be given to pregnant women to optimize AHR's positive effect and reduce the risk of NEC in the event of premature birth. After screening in pregnant mice a variety of compounds already approved by the U.S. Food and Drug Administration for other clinical uses, the researchers observed that one, which they called A18 (clinically known as lansoprazole, a drug approved for the treatment of gastrointestinal hyperacidity), activates the I3C receptor, limits TLR4 signaling and prevents gut bacteria from infiltrating the intestinal wall.  To show the relevance of what they saw in mice, the researchers tested A18 in the laboratory on human intestinal tissue removed from patients with NEC and found the drug produced similar protective results. "These findings enable us to imagine the possibility of developing a maternal diet that can not only boost an infant's overall growth, but also enhance the immune system of a developing fetus and, in turn, reduce the risk of NEC if the baby is born prematurely," says Hackam.   Plant-based diets improve cardiac function, cognitive health Boston University Medical School, February 25, 2021 What if you could improve your heart health and brain function by changing your diet? Boston University School of Medicine researchers have found that by eating more plant-based food such as berries and green leafy vegetables while limiting consumption of foods high in saturated fat and animal products, you can slow down heart failure (HF) and ultimately lower your risk of cognitive decline and dementia. Heart failure (HF) affects over 6.5 million adults in the U.S. In addition to its detrimental effects on several organ systems, presence of HF is associated with higher risk of cognitive decline and dementia. Similarly, changes in cardiac structure and function (cardiac remodeling) that precede the appearance of HF are associated with poor cognitive function and cerebral health.  The adoption of diets, such as the Mediterranean diet (MIND) and the Dietary Approaches to Stop Hypertension (DASH), which are characterized by high intakes of plant-based foods are among lifestyle recommendations for the prevention of HF. However, whether a dietary pattern that emphasizes foods thought to promote the maintenance of neurocognitive health also mitigates changes in cardiac structure and function (cardiac remodeling) has been unclear until now. The researchers found the MIND diet, which emphasizes consumption of berries and green leafy vegetables while limiting intakes of foods high in saturated fat and animal products, positively benefited the hearts' left ventricular function which is responsible for pumping oxygenated blood throughout the body. The researchers evaluated the dietary and echocardiographic data of 2,512 participants of the Framingham Heart Study (Offspring Cohort), compared their MIND diet score to measures of cardiac structure and function and observed that a dietary pattern that emphasizes foods thought to promote the maintenance of neurocognitive health also mitigates cardiac remodeling. According to the researchers previous studies have highlighted the importance of diet as a modifiable risk factor for cognitive decline and dementia. "Our findings highlight the importance of adherence to the MIND diet for a better cardiovascular health and further reduce the burden of cardiovascular disease in the community," explained corresponding author Vanessa Xanthakis, PhD, assistant professor of medicine and biostatistics at BUSM and an Investigator for the Framingham Heart Study. Although Xanthakis acknowledges that following a healthy diet may not always be easy or fit with today's busy schedules, people should make a concerted effort to adhere to healthy eating to help lower risk of disease and achieve better quality of life.         Fear of memory loss impacts well-being and quality of life Trinity College Dublin, February 23, 2021 Research from the Global Brain Health Institute (GBHI) at Trinity College suggests that experiencing high levels of fear about dementia can have harmful effects on older adults' beliefs about their memory and general well-being. To date, few studies have measured the impact of dementia-related fear on daily functioning, despite its clinical relevance. In this new study, published in the journal Aging and Mental Health, researchers investigated if fear of memory decline predicted increased memory failures and poorer quality of life in older adults. Dr. Francesca Farina, Atlantic Fellow for Equity in Brain Health at GBHI, in collaboration with researchers at the University of Cambridge, University of Maastricht and Northwestern University developed a novel scale—known as the Fear of Memory Loss (FAM) scale—to capture different components of fear related to memory loss. Using the scale, healthy older adults aged 55+ were assessed with respect to the different dimensions of fear. Questions probed specific fears like becoming dependent on others, being treated differently by friends or colleagues, and loss of identity, as well as coping strategies like avoiding social situations for fear of embarrassment. Findings from the study showed that having higher levels of fear about dementia was associated with reporting more memory lapses and a lower quality of life. Notably, these results were independent of performance on memory tests and the level of reported anxiety. That is, fears about dementia had a negative influence on peoples' beliefs regardless of how they performed on an objective lab-based memory test, or how they rated their anxiety levels. Key findings: Heightened fear of memory loss significantly predicted lower quality of life and increased self-reported memory failures, after controlling for objective memory performance and general anxiety. There was no difference in the level of fear expressed between those with and without a family history of dementia. Though surprising, this result is consistent with evidence of widespread fear of dementia among the general population. Over half of respondents (57%) said they worried about losing their memory and feared how people would treat them if this happened. The novel FAM scale highlights the important role played by avoidance behaviors in maintaining fear, along with subjective experiences and cognitions. Findings also have important healthcare implications. Fear of dementia is a psychological process that can be modified using interventions such as psycho-education and psychotherapy. The researchers propose a preliminary fear-avoidance model, where perceived changes in memory result in fear, which over time, creates avoidance and social withdrawal. This combination of fear and avoidance has a negative impact on everyday functioning, which then impairs mood and sense of self. Identifying effective ways to challenge fears about dementia could prove beneficial to individuals and society. On the individual level, reducing fear could lead to improvements in how people view their memory function and quality of life. At the societal level, acknowledging and addressing fears about dementia would help to eliminate stigma associated with the condition. Dr. Francesca Farina, Atlantic Fellow at GBHI, and lead author said: "Almost 80% of the general public are concerned about developing dementia, according to the World Alzheimer Report 2019. Evidence also suggests that these fears increase with age. Given global population aging and the increased visibility of dementia, it is crucial that we find ways to address peoples' fears. Understanding and tackling these fears will serve to promote brain health and well-being, and reduce societal stigma for people living with disease and their carers." Tackling Fear and Stigma Through Art Data from the study inspired "Remembering What I Have Forgotten': a fictional diary written from the perspective of someone experiencing symptoms of dementia. Created by Irish artist Aoibheann Brady, student at the National College of Art and Design, the diary aims to capture the feelings and perspectives of people experiencing memory loss. Through the medium of a diary, "Remembering What I Have Forgotten' offers a realistic insight into the experience of dementia, with entries such as "I feel more withdrawn and am not going out or connecting" and "I am anxious that I will make mistakes." This diary, however, was not written by a person—but by a software application known as a chatbot, which had been trained on anonymous interviews with healthcare professionals and carers of people living with dementia. Aoibheann Brady, creator of "Remembering What I Have Forgotten' said: "With this project, I aimed to create work that is a crossover between art and science. I hope it helps demonstrate, to younger generations and members of the art world, that dementia is something that should be considered more in artistic practices."     Diet of fish and olive oils beneficially modifies membrane properties in striatal rat synaptosomes National Institute of Neurology & Neurosurgery (Mexico), February 25, 2021 According to news reporting originating in Mexico City, Mexico, research stated, “Essential fatty acids (EFAs) and non-essential fatty acids (nEFAs) exert experimental and clinical neuroprotection in neurodegenerative diseases. The main EFAs, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), nEFAs, and oleic acid (OA) contained in olive and fish oils are inserted into the cell membranes, but the exact mechanism through which they exert neuroprotection is still unknown.” The news reporters obtained a quote from the research from the National Institute of Neurology & Neurosurgery, “In this study, we assessed the fatty acids content and membrane fluidity in striatal rat synaptosomes after fatty acid-rich diets (olive- or a fish-oil diet, 15% w/w). Then, we evaluated the effect of enriching striatum synaptosomes with fatty acids on the oxidative damage produced by the prooxidants ferrous sulfate (FeSO4) or quinolinic acid (QUIN). Lipid profile analysis in striatal synaptosomes showed that EPA content increased in the fish oil group in comparison with control and olive groups. Furthermore, we found that synaptosomes enriched with fatty acids and incubated with QUIN or FeSO4 showed a significant oxidative damage reduction.” According to the news reporters, the research concluded: “Results suggest that EFAs, particularly EPA, improve membrane fluidity and confer antioxidant effect.” This research has been peer-reviewed.     Soy intake is associated with lowering blood pressure in adults: A meta-analysis of randomized double-blind placebo-controlled trials Shiraz University of Medical Sciences (Iran), February 24, 2021 Soy has several beneficial effects on cardiovascular disease (CVD); however, results of clinical trial studies are equivocal. Thus, the present study sought to discern the efficacy of soy intake on blood pressure. Methods The search process was conducted in PubMed, Scopus, Web of Science, and Cochrane Library, to ascertain studies investigating the efficacy of soy intake on blood pressure in adults, published up to June 2020. A random-effects model was applied to pool mean difference and 95% confidence intervals (CIs). Meta-regression analysis was performed to discern potential sources of heterogeneity. Begg’s and Egger’s methods were conducted to assess publication bias. Results Pooled effects from 17 studies revealed a significant improvement in systolic blood pressure (SBP) (-1.64; -3.25 to -0.04 mmHg; I2 = 50.5 %) and diastolic blood pressure (DBP) (-1.21; -2.29 to -0.12 mmHg, I2 = 50.7 %) following soy consumption, in comparison with controls. Subgroup analysis demonstrated a reduction in both SBP and DBP in younger participants with lower baseline blood pressure and intervention durations of

Research has documented that within the first 6 to 8 hours post exercise, competition, or training – the window of recovery – the combined intake of protein (PRO) and carbohydrate (CHO) per hour – based on body weight (kilograms), is the appropriate mode to accelerate glycogen repletion in the liver, muscles, and circulatory system.The reasoning is the sum of the parts – carbohydrate and protein ingestion – may be greater than either component in isolation. However, research is somewhat inconsistent. The physiological effect is caused by the insulinogenic effects, when a fast -digesting whey protein isolate – high in the essential, branch chain, anabolic amino acid leucine – is selected, as the post-recovery protein of choice.It’s also reported that the optimum refeeding of carbohydrate over the 6 to 8-hour recovery window is 1.2 grams per kilogram (2.2 pounds) of body mass, while the optimum protein refeeding is roughly 0.3 grams per kilogram.Yet, some research says that after a carbohydrate refeeding of greater than 0.8 g/kg/hour a saturation effect takes hold – with more being less, potentially negating the effects, if protein is added to the mix.In a study – Co-Ingestion of Carbohydrate and Protein on Muscle Glycogen Synthesis After Exercise: A Meta-Analysis – which was reported in the February 2021issue of Medicine & Science in Sports & Exercise, researchers from the Military Nutrition Division, U.S. Army Research Institute of Environmental Medicine in Massachusetts, and the Oak Ridge Institute of Science and Education, in Tennessee, the primary objective was, “to aggregate results from multiple studies to characterize the effects of CHO-PRO on glycogen synthesis, during recovery from exercise compared with CHO alone.”The meta-analysis (numerous similar studies), which included research from PubMed and the Cochrane Library database, took place in July of 2019 – with a second search in March of 2020. “The population, intervention, control, and outcome for this meta-analysis were healthy, trained or untrained men or women, CHO-PRO, CHO only, and glycogen synthesis, respectively,” commented the investigators.Read the rest on maxwellnutrition.com

Gary takes on the real issues that the mainstream media is afraid to tackle. Tune in to find out the latest about health news, healing, politics, and the economy.  Becoming an Essentialist Prevent memory loss with a powerful nutrient in cucumbers Salk Institute for Biological Studies, February 16, 2021 The results of a recent study are offering new hope that avoiding memory loss related to aging as well as Alzheimer’s disease could be as simple as eating more cucumbers. Many older adults resign themselves to memory loss as part of the aging process. However, a study out of the the Salk Institute for Biological Studies has shown that this doesn’t have to be the case. The health benefits of cucumbers are many, and one of them seems to be better memory and even the prevention of Alzheimer’s disease. Researchers working with mice that normally developed the symptoms of Alzheimer’s (including memory loss) discovered that a daily dose of a flavonol called fisetin prevented these and other related impairments. This improvement occurred despite the continued formation of amyloid plaques, the brain proteins commonly blamed for Alzheimer’s. A natural food cure for memory loss The compound fisetin is found in numerous vegetables and fruits but is especially concentrated in strawberries and cucumbers. This flavonol is quite effective in stopping memory loss in mice and holds hope for humans as well. In the past, the main approach to treating Alzheimer’s symptoms was to target amyloid plaques in the brain. The findings of this study call into question the assumption that these proteins are largely responsible for the effects of Alzheimer’s. Even in animals with no signs of Alzheimer’s and otherwise normal functioning, fisetin has been shown to improve memory. However, its ability to prevent memory loss associated with Alzheimer’s disease could have profound implications for humans. Cucumbers protect the brain from inflammation Fisetin works by switching on a cellular pathway associated with the process of retrieving memories in the brain. Over a decade ago, other researchers discovered the compound fisetin assists in protecting the neurons of the brain from agingand its associated effects. It was found that this potent compound has both anti-inflammatory and antioxidant effects on brain cells. The list of health benefits of cucumbers, strawberries and other fruits and vegetables containing fisetin now include brain and memory improvements. By extension, fisetin has properties that can be highly beneficial for those at risk for Alzheimer’s. Other health benefits of cucumbers In addition to improving memory and potentially protecting against Alzheimer’s, the cucumber fruit has a range of additional nutritional and health benefits. They are low in calories (a cup of cucumbers contains just 16 calories) and assist in hydration (they are comprised of 95 percent water). They also provide flavonoids, triterpenes and lignans which offer anti-inflammatory, antioxidant and cancer-preventing benefits. The peel and seeds in cucumbers contain beta-carotene for eye health and are the most nutrient-dense portions of the fruit. Cucumber seeds contain calcium and the skin and seeds are also excellent sources of fiber. Other vitamins include potassium, vitamin C, magnesium and manganese.     Testosterone levels increased significantly after DHEA administration among older women Jiangxi University of Traditional Chinese Medicine, February 14, 2021 According to news originating from Jiangxi, People’s Republic of China, research stated, “Despite the fact that numerous clinical studies have evaluated the positive effects of dehydroepiandrosterone (DHEA) supplementation on testosterone concentrations and on the body mass index (BMI), more evidence is needed to certify that DHEA is a BMI-reducing agent in the elderly. This meta-analysis aims to clarify the various incompatible results and investigate the impact of DHEA supplementation on serum testosterone levels and lean body mass in elderly women.” Our news journalists obtained a quote from the research from the Jiangxi University of Traditional Chinese Medicine, “Four scientific databases (EMBASE, PubMed/MEDLINE, Scopus and Web of Science) were searched from inception until 20 August 2020 for trials comparing DHEA with placebo. Results were presented as weighted mean differences (WMDs) and 95 % confidence intervals (CIs) based on the random effects model (DerSimonian-Laird approach). Nine arms with 793 subjects reported testosterone as an outcome measure. The overall results demonstrated that testosterone levels increased significantly after DHEA administration in elderly women (WMD: 17.52 ng/dL, 95 % CI: 6.61, 28.43, P = 0.002). In addition, DHEA administration significantly decreased the BMI (WMD:-0.39 kg/m(2), I-2 = 0.0 %).” According to the news editors, the research concluded: “The results of the current meta-analysis support the use of DHEA supplementation for increasing testosterone concentrations in elderly women.” This research has been peer-reviewed.   How healthy lifestyle behaviours can improve cholesterol profiles Harvard School of Public Health, February 15, 2021 Combining healthy lifestyle interventions reduces heart disease through beneficial effects on different lipoproteins and associated cholesterols, according to a study published February 9 in eLife. Having a healthy lifestyle has long been associated with a lower risk of developing heart disease. The new study provides more detailed information on how healthy lifestyles improve cholesterol, and suggests that combining cholesterol-lowering medications and lifestyle interventions may yield the greatest benefits to heart health. Cholesterol-lowering medications such as statins help reduce heart risks by lowering levels of low-density lipoprotein (LDL) cholesterol, the so-called "bad" cholesterol. Healthy lifestyle interventions, including exercising regularly, having a healthy diet, lowering alcohol consumption and maintaining a healthy weight, have also been shown to lower LDL as well as increase "healthy" high-density lipoprotein (HDL) cholesterol. "Until now, no studies have compared the lipid-lowering effects of cholesterol-lowering medications and healthy lifestyle interventions side by side," says lead author Jiahui Si, Postdoctoral Research Fellow in the Department of Epidemiology at Harvard T.H. Chan School of Public Health, Boston, Massachusetts, US. To address this gap, Si and colleagues used a technique called targeted nuclear magnetic resonance spectroscopy to measure 61 different lipid markers in blood samples from 4,681 participants in the China Kadoorie Biobank, including cases of stroke, coronary heart disease and healthy individuals. They studied lipid markers in the blood of participants who had multiple healthy lifestyle habits and compared them to those of participants with less healthy habits. They found 50 lipid markers associated with a healthy lifestyle. When the team looked at a subset of 927 individuals who had coronary heart disease in the next 10 years and 1,513 healthy individuals, they found 35 lipid markers that showed statistically significant mediation effects in the pathway from healthy lifestyles to the reduction of heart disease. Together, the combined beneficial effects of the lipid changes associated with healthy lifestyle practices were linked to a 14% reduced risk of heart disease. Specifically, very-low-density lipoprotein (VLDL) and HDL levels in the blood were linked to the heart-protecting benefits of healthy lifestyles. "Using a genetic scoring technique, we could compare the effect of cholesterol-lowering drugs with that of lifestyle side by side in the study participants," says co-senior author Liming Liang, Associate Professor of Statistical Genetics in the Department of Epidemiology at Harvard T.H. Chan School of Public Health. "Our analysis confirmed that cholesterol-lowering drugs would have the expected effect in lowering LDL cholesterol, but this is much weaker compared to the effect of healthy behaviours on VLDL cholesterol which also increases the risk of heart disease." Overall, they found that taking cholesterol-lowering medications and engaging in multiple healthy lifestyles would likely help individuals to achieve the greatest heart-protecting benefits because of the complementary effects of the drugs and healthy behaviours. "Lifestyle interventions and lipid-lowering medications may affect different components of the lipid profile, suggesting they are not redundant strategies but could be combined for improved benefits," concludes co-senior author Jun Lv, Professor at the Department of Epidemiology & Biostatistics at the School of Public Health, Peking University Health Science Center, Beijing, China.   Role of Diet in Colorectal Cancer IncidenceUmbrella Review of Meta-analyses of Prospective Observational Studies University of Utah, February 16 Question  How credible is the evidence behind the association of dietary factors with colorectal cancer (CRC) risk in published meta-analyses of prospective observational studies? Findings  This umbrella review of 45 meta-analyses describing 109 associations found convincing evidence for an association between lower CRC risk and higher intakes of dietary fiber, dietary calcium, and yogurt and lower intakes of alcohol and red meat. Meaning  This study suggests that dietary factors may have a role in the development and prevention of CRC, but more research is needed on specific foods for which the evidence remains suggestive. Abstract Importance  Several meta-analyses have summarized evidence for the association between dietary factors and the incidence of colorectal cancer (CRC). However, to date, there has been little synthesis of the strength, precision, and quality of this evidence in aggregate. Objective  To grade the evidence from published meta-analyses of prospective observational studies that assessed the association of dietary patterns, specific foods, food groups, beverages (including alcohol), macronutrients, and micronutrients with the incidence of CRC. Data Sources  MEDLINE, Embase, and the Cochrane Library were searched from database inception to September 2019. Evidence Review  Only meta-analyses of prospective observational studies with a cohort study design were eligible. Evidence of association was graded according to established criteria as follows: convincing, highly suggestive, suggestive, weak, or not significant. Results  From 9954 publications, 222 full-text articles (2.2%) were evaluated for eligibility, and 45 meta-analyses (20.3%) that described 109 associations between dietary factors and CRC incidence were selected. Overall, 35 of the 109 associations (32.1%) were nominally statistically significant using random-effects meta-analysis models; 17 associations (15.6%) demonstrated large heterogeneity between studies (I2 > 50%), whereas small-study effects were found for 11 associations (10.1%). Excess significance bias was not detected for any association between diet and CRC. The primary analysis identified 5 (4.6%) convincing, 2 (1.8%) highly suggestive, 10 (9.2%) suggestive, and 18 (16.5%) weak associations between diet and CRC, while there was no evidence for 74 (67.9%) associations. There was convincing evidence of an association of intake of red meat (high vs low) and alcohol (≥4 drinks/d vs 0 or occasional drinks) with the incidence of CRC and an inverse association of higher vs lower intakes of dietary fiber, calcium, and yogurt with CRC risk. The evidence for convincing associations remained robust following sensitivity analyses. Conclusions and Relevance  This umbrella review found convincing evidence of an association between lower CRC risk and higher intakes of dietary fiber, dietary calcium, and yogurt and lower intakes of alcohol and red meat. More research is needed on specific foods for which evidence remains suggestive, including other dairy products, whole grains, processed meat, and specific dietary patterns.     Pizza, burgers and the like: A single high-fat meal can damage  metabolism Deutsches Diabetes-Zentrum (Germany), February 16, 2021   The global proliferation of overweight and obese people and people with type 2 diabetes is often associated with the consumption of saturated fats. Scientists at the German Diabetes Center (Deutsches Diabetes-Zentrum, DDZ) and the Helmholtz Center in Munich (HMGU) have found that even the one-off consumption of a greater amount of palm oil reduces the body's sensitivity to insulin and causes increased fat deposits as well as changes in the energy metabolism of the liver. The results of the study provide information on the earliest changes in the metabolism of the liver that in the long term lead to fatty liver disease in overweight persons as well as in those with type 2 diabetes.   In the current issue of the "Journal of Clinical Investigation", DZD researchers working at the German Diabetes Center, in conjunction with the Helmholtz Center in Munich and colleagues from Portugal, published a scientific investigation conducted on healthy, slim men, who were given at random a flavored palm oil drink or a glass of clear water in a control experiment. The palm oil drink contained a similar amount of saturated fat as two cheeseburgers with bacon and a large portion of French fries or two salami pizzas. The scientists showed that this single high-fat meal sufficed to reduce the insulin action, e.g. cause insulin resistance and increase the fat content of the liver. In addition, changes in the energy balance of the liver were proven. The observed metabolic changes were similar to changes observed in persons with type 2diabetes or non-alcoholic fatty liver disease (NAFLD). NAFLD is the most common liver disease in the industrial nations and associated with obesity, the so-called "metabolic syndrome," and is associated with an increased risk in developing type 2 diabetes. Furthermore, NAFLD in advanced stages can result in severe liver damage.   "The surprise was that a single dosage of palm oil has such a rapid and direct impact on the liver of a healthy person and that the amount of fat administered already triggered insulin resistance", explained Prof. Dr. Michael Roden, scientist, Managing Director and Chairman at the DDZ and the German Center for Diabetes Research (Deutsches Zentrum für Diabetesforschung, DZD). "A special feature of our study is that we monitored the liver metabolism of people with a predominantly non-invasive technology, e.g. by magnetic resonance spectroscopy. This allows us to track the storage of sugar and fat as well as the energy metabolism of the mitochondria (power plants of the cell)." Thanks to the new methods of investigation, the scientists were able to verify that the intake of palm oil affects the metabolic activity of muscles, liver and fatty tissue. The induced insulin resistance leads to an increased new formation of sugar in the liver with a concomitant decreased sugar absorption in the skeletal muscles - a mechanism that makes the glucose level rise in persons afflicted with type 2 diabetes and its pre-stages. In addition, the insulin resistance of the fatty tissue causes an increased release of fats into the blood stream, which in turn continues to foster the insulin resistance. The increased availability of fat leads to an increased workload for the mitochondria, which can in the long term overtax these cellular power plants and contribute to the emergence of a liver disease.   The team of Prof. Roden suspects that healthy people, depending on genetic predisposition, can easily manage this direct impact of fatty food on the metabolism. The long-term consequences for regular eaters of such high-fat meals can be far more problematic, however.    

Serrapeptase is a proteolytic enzyme produced by bacteria in the gut of a silkworm. It is used by the silkworm to dissolve the cocoon. It's hailed as a natural anti-inflammatory, with lots of promise and with no side effects. It is also claimed to have an effect against the build-up of cardiovascular plaque. But does serrapeptase work?  If you go to sources like LEI (Life Extension Institute), you get a great story about the "huge potential" and "no reported side effects" of serrapeptase.  But if you go to harder science sources (like ClinicalTrials.gov, Cochrane Library, PubMed, Medline), you would get a different story. For more information, contact us at 859-721-1414 or myhealth@prevmedheartrisk.com. Also, check out the following resources: PrevMed's blog articlePrevMed's websitePrevMed's YouTube channelPrevMed's Facebook page

In this episode, we're discussing the different types of psychological therapies available for the treatment of chronic pain. Do they help? Are they safe? How much confidence can we place in them and what we should further investigate regarding this topic as we move forward? My expert guest this episode is Dr. Amanda Williams. Amanda was a full-time clinician in a pain management program for many years, then she transitioned to teaching and research. She's a professor of clinical health psychology at The University College London and a consultant clinical psychologist at the Pain Management Centre University College London Hospital in the United Kingdom. We discussed the findings from her paper called , which can be found in the August 2020 Cochrane Library of Systematic Reviews. The paper updates the literature regarding the effectiveness of different kinds of psychological therapy, including traditional cognitive behavioral therapy, acceptance and commitment therapy, and behavioral therapy. It also asks the question as to whether these interventions are safe and if we've investigated safety and harm enough in the literature. This paper was well-received by many, however, as with any study, there were some questions regarding the findings and how much emphasis we should place on psychological therapies versus other types of therapies to help people living with chronic pain. The paper also had some significant criticisms as to developing research base around acceptance and commitment therapy for chronic pain, a topic we've discussed many times on the show. It's important that as professionals and as general members of the public, we’re informed as to the argument and all sides of the literature, research, and perspectives with regard to the various treatments of psychological therapies for the treatment of chronic pain. We discuss all of this and more on this episode. Let's meet Dr. Amanda Williams. Love the show? Subscribe, rate, review, and share! Here’s How » Join the Healing Pain Podcast Community today: integrativepainsciencinstitute.com Healing Pain Podcast Facebook Healing Pain Podcast Twitter Healing Pain Podcast YouTube Healing Pain Podcast LinkedIn Healing Pain Podcast Instagram

This is the 75th anniversary of water fluoridation. Do we still need it? How do we know? To get there I want to tell you about the Cochrane Library -- what it is and what it does. https://en.wikipedia.org/wiki/Cochrane_Library https://pubmed.ncbi.nlm.nih.gov/26092033/  

This week on MIA Radio, we present the second part of our podcast to join in the events for World Benzodiazepine Awareness Day 2020 (W-BAD). In part one, we interviewed Angela Peacock and talked about her experiences of taking and coming off benzodiazepines and also her involvement in the film Medicating Normal, which has a special screening and panel discussion on July the 11th at 1:00 PM EST. And before we go on, I just wanted to say that these podcasts would not be possible without the efforts of W-BAD lead operations volunteer Nicole Lamberson, who goes above and beyond to make these interviews possible. Later in this episode, we will hear from Baylissa Frederick, who is a therapeutic coach and psychotherapist with over two decades' experience working with clients affected by prescribed drug injury. But before we chat with Baylissa, I'm delighted to get the chance to talk with clinical pharmacologist Dr. Jim Wright. Jim is Emeritus Professor in the Departments of Anesthesiology, Pharmacology, and Therapeutics in Medicine at the University of British Columbia. Jim obtained his MD from the University of Alberta in 1968, and his PhD in pharmacology from McGill University in 1976. He is a practicing specialist in internal medicine and clinical pharmacology. He is also Editor in Chief of the Therapeutics Letter and he sits on the editorial boards of PLoS One and the Cochrane Library. Dr. Wright’s research focuses on issues relating to the appropriate use of prescription drugs, clinical pharmacology, clinical trials, systematic review, meta-analysis, and knowledge translation.

An interview with Dr. Eric Roeland from Massachusetts General Hospital Cancer Center on “Management of Cancer Cachexia: ASCO Guideline.” This guideline provides evidence-based recommendations on the clinical management of cancer cachexia in adult patients with advanced cancer. Recommendations are made on both pharmacologic and nutritional interventions. Read the full guideline at www.asco.org/supportive-care-guidelines   The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Hello and welcome to the ASCO Guidelines Podcast Series brought to you by the ASCO Podcast Network, a collection of nine programs covering a range of educational and scientific content and offering enriching insight into the world of cancer care. You can find all the shows including this one, at podcast.asco.org. My name is Brittany Harvey, and today I'm speaking with Dr. Eric Roland from Massachusetts General Hospital Cancer Center. Lead author on Management of Cancer Cachexia, ASCO Guideline. Thank you for being here, Dr. Roland. Well thank you very much. Before we get into the content of this guideline, I want to note that all conflict of interest disclosure information for the expert panel is available online with the publication of the guideline in the Journal of Clinical Oncology. Dr. Roland, do you have any conflicts of interest to disclose? Yes, within the last two years, I've served as a consultant for Asahi Kasei Pharmaceuticals, DIG Consulting, Napo Pharmaceuticals, American Imaging Management, Immuneering Corporation, and Prime Oncology. I've also served on advisory boards for Herron Pharmaceuticals and Vector Oncology. And I serve as a member on the Data Safety Monitoring Boards for Oragenics, Kalyra Pharmaceuticals, and [INAUDIBLE] Life Sciences Pharmaceutical Company. Thank you. Then first, can you give us a general overview of what this guideline covers? Sure. We performed a systematic review of the literature regarding available evidence for nutritional and pharmacologic interventions for cancer cachexia. Specifically, we searched PubMed and the Cochrane Library for randomized controlled trials and systematic reviews published between 1966 in 2019. We focused our review on adult patients with advanced or incurable cancer. And given the highly variable nature of cancer cachexia, we specifically evaluated the endpoints of loss of appetite or anorexia, body weight, and lean body mass, or skeletal muscle. Our targeted audience included clinicians as well as patients and caregivers. Can you provide us with a little background on cancer cachexia? Yes, first I think it's incredibly important for us to define cancer cachexia, especially given its prevalence in cancer care. Traditionally, cancer cachexia has been defined as a certain amount of weight loss over a defined time period. However, cachexia is much more complicated than weight loss alone. It is a multifactorial syndrome characterized by loss of appetite, weight, and skeletal muscle, which leads to fatigue, functional impairment, increased treatment related toxicity, poor quality of life, and even reduced survival. And as clinicians, we need to try to identify any reversible causes contributing to cachexia and treat them. This of course, includes treating the underlying cancer when possible. Additionally, it's essential for patients to receive optimal palliation of all symptoms that may be interfering with the intake of calories, such as pain, nausea, vomiting, constipation, diarrhea, and depression. Therefore, as clinicians, we need to work in teams of experts that might include expertise in pain, palliative care, nutrition, physical occupational therapy, and mental health where available. We also need to introduce and discuss the term, cachexia, with our patients and their caregivers, who often have never heard of it before. They may not understand that this term is unique and very different from weight loss alone. I personally have found that describing the unique nature of cachexia and providing the information to patients and caregivers can be very helpful. Additionally, we need to recognize that food is a very complicated issue. And when we engage patients and caregivers around issues of food, we need to recognize that there are informational needs, but there are also emotional needs. And as clinicians, we help patients and caregivers gain access to evidence based information and interventions, but we equally need to ensure that they receive emotional support. Food represents hope and control in an uncontrollable situation. And not being able to eat or feed a loved one can cause severe distress. Therefore, we need to engage patients and caregivers regarding these emotional issues and make sure they feel heard. We can also reach out to our mental health colleagues, such as social workers and psychologists, who may help us support patients and caregivers in this difficult issue. Then, what are the key recommendations covered in this guideline? With regard to our systematic review, we identified 20 systematic reviews and 13 additional randomized controlled trials. And from this data, we made the following recommendations. First, we found limited data supporting the integration of dietary counseling with or without oral nutritional supplements. However, given the lack of harm and the critical role of educating patients and caregivers, we felt it was important to support referring patients with incurable cancer and loss of appetite and/or body weight to registered dietitian for assessment and counseling. It's critical for patients and caregivers to learn about practical and safe approaches to feeding. Specifically, registered dietitians may help develop strategies, such as shifting away from three larger meals per day towards frequent high protein, high calorie, nutrient dense snacks. Dietitians can also address questions regarding specific diets, including fad diets and unproven or extreme diets. Moreover, clinicians should not routinely offer enteral tube feeding or parenteral nutrition to manage cachexia in patients with incurable cancer. A short term trial of parenteral nutrition may be offered to a very select group of patients, such as patients with a reversible bowel obstruction, or short gut, or issues with malabsorption, but otherwise reasonably fit. We also can consider discontinuing previously initiated enteral parenteral nutrition near the end of life, as it is associated with net harm at that time. With regard to pharmacologic interventions, there are no FDA approved drugs to treat cancer cachexia. Yet there is sufficient data to support two pharmacologic interventions associated with improvements in appetite and/or body weight. And these include progesterone analogs, such as megestrol acetate and corticosteroids. The optimal dose and timing of each drug remains unknown. Regarding megestrol acetate, data support its role in improving appetite, modest weight gain, and improvement in quality of life. However, the weight gain associated with megestrol acetate is primarily fat and not skeletal muscle. We also need to be aware of side effects of megestrol acetate, including an increased risk of thromboembolic events, edema, adrenal insufficiency, and even an increased risk of death. As for corticosteroids, the first published double-blind randomized study dates back all the way to 1974, which showed an improvement in appetite and sense of well-being. However, clinicians are aware of the multiple side effects associated with corticosteroid use, that often limit initiation and timing of their use. Additionally, the weight gain associated with corticosteroids is not skeletal muscle. As important as it is to know what drugs are evidence based, it is also important to note what pharmacologic approaches are not supported by evidence. There are many agents that have been evaluated in clinical trials without any evidence to support an improvement in cancer cachexia outcomes. One such drug that frequently is asked about is dronabinol or the general class of cannabinoids. Insufficient data was available to recommend dronabinol or medical cannabis, and they have notable side effects, including altered mental status and a higher risk of falls. Especially in the elderly. Why is this guideline important? And how will it impact practice? Cachexia is a very common clinical entity and causes lots of distress for patients and caregivers. Oftentimes, the issues regarding nutrition and weight loss can be the central focus of clinical appointments and conversations with oncologists. We need to ensure that patients and caregivers have access to evidence based information and recognize that some interventions may be associated with more harm than benefit. And finally, you've just spoken to this a bit, but how will these guideline recommendations affect patients? Primarily, I think these cancer cachexia guidelines will serve as a great educational resource. They will also allow patients to better understand the risks associated with some of the pharmacologic interventions. I also think it's critical to define the current state of evidence in cancer cachexia, as we have many new exciting clinical trials evaluating novel agents in the setting. Furthermore, as a cancer community, we need to ensure that interventional trials are focused on clinically meaningful endpoints, such as improvements in appetite, muscle mass, and quality of life. We also need to encourage a rigorous but expedited approval of these agents, given the lack of any FDA approved drugs in this setting. Lastly, we need to recognize this is a multi-modal syndrome that requires the help and expertise of our interdisciplinary colleagues. Supporting our patients and their caregivers with this very difficult syndrome requires as much help as possible. Great. Thank you for your work on these guidelines and for taking the time to speak with me today, Dr. Roland. Thank you so much, Brittany. I would also like to recognize and thank ASCO for its support of these guidelines, the talented ASCO staff, and the experts who contributed. Most of all, I'd like to recognize our patients and their caregivers. And thank you to all of our listeners for tuning into the ASCO Guidelines Podcast Series. To read the full guideline, go to www.asco.org/supportive-care-cancer-guidelines. This guideline also has a companion, cancer.net podcast episode. Cancer.net is the patient information website of ASCO. And we encourage you to learn more by tuning into their episode. You can find their podcast and all ASCO podcasts at podcast.asco.org. You can also find many of our guidelines and interactive resources in the free ASCO guidelines app, available in iTunes or the Google Play Store. If you have enjoyed what you've heard today, please rate and review the podcast. And be sure to subscribe, so you never miss an episode.

People with fibromyalgia have persistent, widespread body pain and there are more than 30 Cochrane Reviews of interventions that might help them. In September 2019, a new review was added to the Cochrane Library, studying the effects of flexibility exercise training. We asked its lead author, Soo Kim from the University of Saskatchewan in Canada, to tell us about the findings.

People with fibromyalgia have persistent, widespread body pain and there are more than 30 Cochrane Reviews of interventions that might help them. In September 2019, a new review was added to the Cochrane Library, studying the effects of flexibility exercise training. We asked its lead author, Soo Kim from the University of Saskatchewan in Canada, to tell us about the findings.

People with fibromyalgia have persistent, widespread body pain and there are more than 30 Cochrane Reviews of interventions that might help them. In September 2019, a new review was added to the Cochrane Library, studying the effects of flexibility exercise training. We asked its lead author, Soo Kim from the University of Saskatchewan in Canada, to tell us about the findings.

After ten years at the helm of the Cochrane Library, Dr David Tovey recently stepped down as Editor-in-Chief. This week he joins Ray to reflect on Cochrane's past, present and future and share some of the challenges and rewards of leading one of the world's largest and most trusted health research networks.

After ten years at the helm of the Cochrane Library, Dr David Tovey recently stepped down as Editor-in-Chief. This week he joins Ray to reflect on Cochrane's past, present and future and share some of the challenges and rewards of leading one of the world's largest and most trusted health research networks.

Helen Macdonald and Carl Heneghan are back again talking about what's happened in the world of evidence this month. (1.20) Carl grinds his gears over general health checks, with an update in the Cochrane Library. (9.15) Helen is surprised by new research which looks at over prescription of antibiotics - but this time because the courses prescribed are far longer than guidelines suggest. (22.30) What is the true 99th centile of high sensitivity cardiac troponin in hospital patients? (29.02) Is it time to abandon statistical significance and be aware of the problem of the transposed conditional. Reading list: General health checks in adults for reducing morbidity and mortality from disease - https://www.ncbi.nlm.nih.gov/pubmed/30699470?dopt=Abstract Duration of antibiotic treatment for common infections in English primary care -https://www.bmj.com/content/364/bmj.l440 True 99th centile of high sensitivity cardiac troponin for hospital patients - https://www.bmj.com/content/364/bmj.l440 Significant debate - https://www.nature.com/magazine-assets/d41586-019-00874-8/d41586-019-00874-8.pdf The false positive risk: a proposal concerning what to do about p-values - https://www.youtube.com/watch?v=jZWgijUnIxI http://www.onemol.org.uk/?page_id=456

Helen Macdonald and Carl Heneghan are back again talking about what's happened in the world of evidence this month. (1.20) Carl grinds his gears over general health checks, with an update in the Cochrane Library. (9.15) Helen is surprised by new research which looks at over prescription of antibiotics - but this time because the courses prescribed are far longer than guidelines suggest. (22.30) What is the true 99th centile of high sensitivity cardiac troponin in hospital patients? (29.02) Is it time to abandon statistical significance and be aware of the problem of the transposed conditional. Reading list: General health checks in adults for reducing morbidity and mortality from disease - https://www.ncbi.nlm.nih.gov/pubmed/30699470?dopt=Abstract Duration of antibiotic treatment for common infections in English primary care -https://www.bmj.com/content/364/bmj.l440 True 99th centile of high sensitivity cardiac troponin for hospital patients - https://www.bmj.com/content/364/bmj.l440 Significant debate - https://www.nature.com/magazine-assets/d41586-019-00874-8/d41586-019-00874-8.pdf The false positive risk: a proposal concerning what to do about p-values - https://www.youtube.com/watch?v=jZWgijUnIxI http://www.onemol.org.uk/?page_id=456

Using medicine to treat colds among children under six years old is ineffective and may cause harmful side effects, a recent study says. Researchers from Belgium and Australia published the results of the study on the British Medical Journal. To be able to look into the effectiveness of different cold medicines, experts analyzed subject-related articles from Cochrane Library and a search engine called PubMed. After examining the information gathered, experts found no sufficient evidence that medicine alleviates cold symptoms. For this reason, the researchers said that doctors should be cautious in prescribing cold medicine even if previous studies show that it may be effective for children between six and 12 years old. According to experts, certain medications carry potentially harmful side effects like upset stomach, headache, increased blood pressure, as well as convulsions or uncontrollable muscle movements. Instead of prescribing cold medicines, the authors of the study encouraged doctors to assure patients that the symptoms would die down within seven to 10 days. Dr. Partha Nandi, an expert in internal medicine, strongly supports the outcome of the study. In an article posted on the website “Fox 47 News,” Dr. Nandi cited the results of the study and gave suggestions on how to help children with colds feel better. Rather than treating colds with medicine, Dr. Nandi recommended that parents use accurate pain and fever medications to decrease children's discomfort. Moreover, the doctor emphasized that patients with cold symptoms should drink a lot of water to stay hydrated.

Some links from the show: Vitamin A and night visions British Journal of Opthalmology: Night vision in a case of vitamin A deficiency due to malabsorption Types of vitamin A National Institutes of Health: Vitamin A Overdosing on vitamin A Wikipedia: Hypervitaminosis A How vegans get B12 PETA: Vegan B12 sources that will make you healthy in body and mind Linus Pauling's vitamin C quest Vox: How Linus Pauling duped America into believing vitamin C cures colds Does vitamin C treat colds? Cochrane Library: Vitamin C for preventing and treating the common cold WebMD: Vitamin C for the common cold

Ivor Cummins is a Biochemical Engineer who in 2012 was disturbed by a set of his own abnormal blood test results. Consultation with multiple doctors yielded little insight into the cause of his elevated cholesterol, ferritin and GGT so he turned to his analytical roots to study the problem. In the process, he evaluated hundreds of scientific papers, ultimately concluding that that flawed hypotheses and a breach of the scientific method have resulted in the current “diabesity” epidemic. Ivor is here today with Dr. Tommy Wood talking on topics related to his well-referenced new book, Eat Rich, Live Long: Mastering the Low-Carb & Keto Spectrum for Weight Loss and Great Health. They also discuss the trouble with polyunsaturated oils, advice on fat loss for the insulin sensitive, and the best test for cardiovascular disease risk (hint: it’s not LDL). If you enjoy this podcast, Ivor is a regular presenter at low-carb/keto events and maintains an active blog and social media presence. Here’s the outline of this interview with Ivor Cummins: [00:00:17] Keto Summit, Dave Feldman. [00:00:48] Boundless Health Podcast with Dr. Bret Scher. [00:01:57] Podcast: The True Root Causes of Cardiovascular Disease, with Dr. Jeffry Gerber. [00:02:15] Book: Eat Rich, Live Long: Mastering the Low-Carb & Keto Spectrum for Weight Loss and Great Health, by Ivor Cummins and Jeffry Gerber, MD. [00:02:29] Videos: here and here. [00:03:20] Insulin, IGF-1, acellular carbs. [00:03:56] Sunlight exposure, 25-OH-D video. [00:04:37] Minerals, Study: DiNicolantonio, James J., James H. O’Keefe, and William Wilson. "Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis." Open Heart 5.1 (2018): e000668. [00:05:28] Gabor Erdosi, Lower Insulin Facebook Group. [00:05:43] Video: Roads to Ruin? from Physicians for Ancestral Health 2017 conference. [00:06:01] Guðmundur Jóhannsson, gut health; Podcast: Foodloose Iceland. [00:07:40] Study: Schwalfenberg, Gerry K., and Stephen J. Genuis. "The importance of magnesium in clinical healthcare." Scientifica 2017 (2017). [00:08:10] Industrial seed oils. [00:09:05] Unilever sells its margarine business. [00:10:17] Studies: Alvheim, Anita Røyneberg, et al. "Dietary Linoleic Acid Elevates the Endocannabinoids 2‐AG and Anandamide and Promotes Weight Gain in Mice Fed a Low Fat Diet." Lipids 49.1 (2014): 59-69. And: Alvheim, Anita R., et al. "Dietary Linoleic Acid Elevates Endogenous 2‐AG and Anandamide and Induces Obesity." Obesity 20.10 (2012): 1984-1994. [00:10:48] Studies: Nanji, Amin A., and Samuel W. French. "Dietary factors and alcoholic cirrhosis." Alcoholism: Clinical and Experimental Research 10.3 (1986): 271-273. And: Kirpich, Irina A., et al. "Alcoholic liver disease: update on the role of dietary fat." Biomolecules 6.1 (2016): 1. [00:12:09] Book: Deep Nutrition: Why Your Genes Need Traditional Food, by Cate Shanahan, M.D. [00:12:45] Studies: 1. Ramsden, Christopher E., et al. "The Sydney Diet Heart Study: a randomised controlled trial of linoleic acid for secondary prevention of coronary heart disease and death." The FASEB Journal 27.1 Supplement (2013): 127-4. 2. Frantz, Ivan D., et al. "Test of effect of lipid lowering by diet on cardiovascular risk. The Minnesota Coronary Survey." Arteriosclerosis, Thrombosis, and Vascular Biology 9.1 (1989): 129-135. 3. Strandberg, Timo E., et al. "Mortality in participants and non-participants of a multifactorial prevention study of cardiovascular diseases: a 28 year follow up of the Helsinki Businessmen Study." Heart 74.4 (1995): 449-454. 4. Rose, G. A., W. B. Thomson, and R. T. Williams. "Corn oil in treatment of ischaemic heart disease." British medical journal 1.5449 (1965): 1531. [00:13:47] Study: Hooper, Lee, et al. "Reduction in saturated fat intake for cardiovascular disease." The Cochrane Library (2015). [00:15:28] Study: Ip, Clement, Christopher A. Carter, and Margot M. Ip. "Requirement of essential fatty acid for mammary tumorigenesis in the rat." Cancer Research 45.5 (1985): 1997-2001. [00:16:28] Study: Pearce, Morton Lee, and Seymour Dayton. "Incidence of cancer in men on a diet high in polyunsaturated fat." The Lancet 297.7697 (1971): 464-467. [00:16:56] Breast milk composition is now almost 50% PUFA. [00:17:50] David Bobbett. [00:19:59] Book structure. [00:20:51] Fat-loss for the insulin sensitive. [00:21:10] Videos: Jeff Gerber interviews Simon Saunders and Marty Kendall. [00:23:03] Ghrelin. [00:24:21] Protein and lean body mass. [00:26:05] Glucagon, mTOR. [00:26:22] Ron Rosedale. [00:26:34] Valter Longo. [00:27:02] IGF-1 U-shaped curve. [00:28:06] Study: Levine, Morgan E., et al. "Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population." Cell metabolism 19.3 (2014): 407-417. [00:28:49] Book: Protein Power: The High-Protein/Low Carbohydrate Way to Lose Weight, Feel Fit, and Boost Your Health - in Just Weeks! By Michael Eades and Mary Dan Eades. [00:30:39] Study: Levine, Morgan E., et al. "Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population." Cell metabolism 19.3 (2014): 407-417. [00:31:06] NHANES. [00:31:18] Study: Cohen, Evan, et al. "Statistical review of US macronutrient consumption data, 1965–2011: Americans have been following dietary guidelines, coincident with the rise in obesity." Nutrition 31.5 (2015): 727-732. [00:32:20] Kitavans. [00:34:05] Hyperlipid and Denise Minger. [00:36:37] Icelandic diets for longevity [00:39:07] Cardiovascular disease. [00:39:35] Basic lipid panel. [00:39:45] Study: Castelli, William P. "Lipids, risk factors and ischaemic heart disease." Atherosclerosis 124 (1996): S1-S9. [00:40:24] Ratios. [00:41:54] Study: Johnson, Kevin M., David A. Dowe, and James A. Brink. "Traditional clinical risk assessment tools do not accurately predict coronary atherosclerotic plaque burden: a CT angiography study." American Journal of Roentgenology 192.1 (2009): 235-243. Commentary: Ware, William R. "The mainstream hypothesis that LDL cholesterol drives atherosclerosis may have been falsified by non-invasive imaging of coronary artery plaque burden and progression." Medical hypotheses 73.4 (2009): 596-600. [00:42:30] Familial Hypercholesterolemia and CVD. [00:43:27] cholesterolcode.com, remnant cholesterol, Plasma Atherogenic Index. [00:44:36] Podcast: Health Outcome-Based Optimal Reference Ranges for Cholesterol [00:46:06] Coronary calcium scan. [00:46:25] Study: Nasir, Khurram, et al. "Interplay of Coronary Artery Calcification and Traditional Risk Factors for the Prediction of All-Cause Mortality in Asymptomatic Individuals Clinical Perspective." Circulation: Cardiovascular Imaging 5.4 (2012): 467-473. [00:47:54] Longitudinal score. [00:49:41] Plaque density. [00:50:11] Interview with Matt Budoff. [00:52:37] Video: Dr. Eades at Low Carb Breckenridge, Agatston score. [00:54:38] The Fat Emperor. [00:54:53] Low-carb Breckenridge 2018. [00:55:10] Ketofest, Keto Con, Low-carb USA, Refind Health. [00:55:45] Widowmaker movie.

Acute bronchitis is one of the commonest respiratory tract infections seen by general or family practitioners, with several reviews now available in the Cochrane Library and one of these, of the effects of antibiotics, was updated in June 2017. We asked the lead author, Susan Smith, a GP from Dublin, Ireland, based at the Department of General Practice in the RCSI Medical School, to tell us what they found.