Podcasts about Carnevale

WDW Radio # 724 - Adventures by Disney to Italy Recap - Part 2 As we continue our recap and review of our WDW Radio Adventures by Disney trip to Italy, we continue on to one of the most beautiful and surprising stops on our journey, Orvieto. From there, we visit Tuscany, which was remarkable for so many reasons, before continuing on to the romance and renaissance of Florence, then punctuating our adventure with Carnevale in Florence. We discuss not only the highlights and special moments, but what made this, and Adventures by Disney as a whole, truly special and unique. Share your thoughts in the WDW Radio Clubhouse at WDWRadio.com/Clubhouse, or call the voicemail at 407-900-9391 (WDW1) and share your story on the show. But for now... sit back, relax, and enjoy this week's episode from the Archives on the WDW Radio show. ---------------------------------- WDWRadio.com - Visit the site and blog WDWRadio.com/Clubhouse - Join the community and conversation on Facebook WDWRadioNATION - Get monthly rewards, and help support the show WDWRadioLIVE.com - Watch and chat LIVE Wednesdays at 7:30pm ET WDWRadio.com/Podcasts - Show notes, past episodes, links, and photos WDWRadio.com/Events - WDW Radio Disney meets, events, cruises, and more! WDWRadio.com/Shirts - Disney, Marvel, Star Wars, logo gear and more! 407-900-9391 - Call the voicemail with a question, comment or "Hello!" from the parks THANK YOU for your support by voting WDW Radio Best Travel Podcast for 9 consecutive years! Sit back, relax, and enjoy this week's episode of the WDW Radio show. Thanks for listening! Be sure to tune in next week! ---------------------------------- LouMongello.com - Let me help you turn what you love into what you do and turn your passion into your profession with one-on-one mentoring, mastermind groups, and my MomentumWorkshop and Retreat in Walt Disney World. I am also a keynote keynote speaker who can present at your event, conference, business, or school, and provide mentoring and consulting to individuals and organizations looking to build their businesses and brands. I speak on a variety of topics, including sharing the magic of Disney, and teaching how to deliver exceptional customer service, social media, podcasting, live video, community, following your dreams, and more. ---------------------------------- LET'S CONNECT! WDWRadio.com/Community Facebook.com/WDWRadio Instagram.com/LouMongello Twitter.com/LouMongello YouTube.com/WDWRadio Pinterest.com/LouMongello LinkedIn.com/in/LouMongello

In 2020 over 18 million students applied to go to college. And 17.7 million of those students applied for financial aid. Applying for financial aid can be a daunting and emotional process for students and families. In my research for this episode, I learned that in 2020 the number of submitted applications of the FAFSA, the Free Application for Federal Student Aid, fell by 50,000 applicants. Guiding students and families along that journey is a global community of Financial Aid Directors and Counselors who are committed to simplifying the complexities and easing the pathway to graduation for the next generation. This episode is dedicated to these unsung heroes, these keepers of all those forms and even some of the memories. Those makers of dreams. With their focus ever on the next generation pursuing higher education and newfound purpose, their work is seldom heralded. And while the statistics and metrics are all too easily cited, we rarely hear of the stories behind the numbers. Nor do we get to meet the people whose lives have been changed forever by the work of a Financial Aid counselor, like David Carnevale. In this episode I bring two of those stories to light. Told nearly 20 years later, this story of change is a reunion between a young student and the counselor who helped him find his path to independence and eventually graduation. Thank you to David and Brian for joining the podcast and trusting this platform to echo their stories while championing the next generation of changemakers.

Jessica Machado fills in for Howie Carr to give listeners and inside look at the restructuring of the Massachusetts Republican Party. Newly elected Chairwoman Amy Carnevale joins the show to discuss the ongoing debt problem, the search for new candidates, and the term "RINO."

Sign up to our newsletter here. Join our facebook group here or join our Discord here.You can physically send us stuff to PO BOX 7127, Reservoir East, Victoria, 3073.Want to help support the show?Sanspants+ | Shop | TeesWant to get in contact with us?Email | Twitter | Website | Facebook | RedditOr individually at;Hayden | CassShut Up a Second is hosted and produced by Cass Paige and Hayden Bleechmore.Recorded and produced on Wurundjeri land, we respectfully acknowledge the Wurundjeri People of the Kulin Nation, pay our respect to their Elders past and present, and recognise that sovereignty was never ceded. Hosted on Acast. See acast.com/privacy for more information.

Amy Carnevale is a Government Affairs Advisor and the new Chairman of the Massachusetts Republican Party. Amy has over a decade of experience in private practices, including K & L Gates' locations in Boston and Washington, DC., where she focused on public policy advocacy, economic development, federal funding, healthcare policy, and technology, among others. She serves as a member of the Governor's Commission on Intellectual Disability and is a Committee Member of the U.S. Chamber of Commerce. She holds a Bachelor's degree in Political Science with Honors from George Washington University and previously served as a member of the board of the Special Education Parent Advisory Council for the Marblehead Public School System. Amy joins me today to share what inspired her to get involved in politics and why she decided to run for the Republican Party Chair position for Massachusetts. We discuss how she's taking steps to improve the Massachusetts resident's perception of the Republican Party and discuss the importance of getting involved with your local school boards and other local elections. Amy also explains why communication, transparency, being authentic, and following your gut is important when deciding whether you should run for public office. “If you want that change, you have to be part of it..” - Amy Carnevale This week on Political Contessa: How Amy became involved in the political landscape Why Amy ran for Chairwoman of the Massachusetts Republican Party Amy's mission to improve the public's perception of the Republican party Helping Republican candidates win more elections The importance of getting involved in local elections Amy's advice to others that are considering getting involved or running for office Connect with Amy Carnevale: Amy Carnevale on LinkedIn Awaken Your Inner Political Contessa Thanks for tuning into this week's episode of Political Contessa. If you enjoyed this episode, please subscribe and leave a review wherever you get your podcasts. Spotify I Stitcher I Apple Podcasts I iHeart Radio I TuneIn I Google Podcasts Be sure to share your favorite episodes on social media. And if you've ever considered running for office – or know a woman who should – head over to politicalcontessa.com to grab my quick guide, Secrets from the Campaign Trail. It will show you five signs to tell you you're ready to enter the political arena.See omnystudio.com/listener for privacy information.

The BS Boys have done what many thought to be impossible and have recorded two Based Reactions in the space of a week. This time, they've locked their good friend Joel Duscher out of the studio and replaced him with their other good friend Adam Carnevale to celebrate the release of their silly little Dungeons and Dragons movie. Full spoilers! Learn more about your ad choices. Visit megaphone.fm/adchoices

This week on Thumb Cramps the FINAL MARCHTASY burden is shared as we're joined by Final Fantasy expert Adam Carnevale to look at Stranger of Paradise: Final Fantasy Origin for the PS5, Lunacid for the PC and Solasta: Crown of the Magister for the PC and yes, these are all real games despite what their names suggest. One more nail to go.Email us at ThumbCrampsPod@gmail.com Find us on Twitter;Jackson | Duscher | Thumb Cramps | AdamWatch us on Twitch;Jackson | Duscher | AdamYou can now physically send us stuff to PO BOX 7127, Reservoir East, Victoria, 3073.Join our facebook group here or join our Discord here.Theme music by Benny Davis! You can find all his stuff at his website or check out his YouTube channel. Hosted on Acast. See acast.com/privacy for more information.

Featured Resources Invasive Species Terminology - Iannone, B. V., Carnevale, S., Main, M. B., Hill, J. E., McConnell, J. B., Johnson, S. A., Enloe, S. F., Andreu, M., Bell, E. C., Cuda, J. P., & Baker, S. M. (2020). Invasive Species Terminology: Standardizing for Stakeholder Education. The Journal of Extension, 58(3), Article 27. https://tigerprints.clemson.edu/joe/vol58/iss3/27 Bansal, S., S.C. Lishawa, S. Newman, B.A. Tangen, D. Wilcox, D. Albert, M.J. Anteau, M.J. Chimney, R.L. Cressey, E. DeKeyser, K.J. Elgersma, S.A. Finkelstein, J. Freeland, R.Grosshans, P.E. Klug, D.J. Larkin, B.A. Lawrence, G. Linz, J. Marburger, G. Noe, C. Otto, N. Reo, J. Richards, C. Richardson, A.J. Schrank, D. Svedarsky, S. Travis, N. Tuchman, and L. Windham-Myers. 2019. Typha (cattail) invasion in North American wetlands: biology, regional problems, impacts, ecosystem services, and management. Wetlands 39(4):645-684. doi: 10.1007/s13157-019-01174-7   Helpful Resources Cattail [Typha species] South Florida Water Management District (SFWMD)   SFWMD Scientific Publications (and 2022 Environmental Report) — Working In The Weeds is a podcast by the ⁠University of Florida/IFAS Center for Aquatics and Invasive Plants⁠. This series connects scientists with stakeholders to clarify and discuss issues surrounding aquatic and invasive plants, while also highlighting the research being conducted at the Center. Do you have topics or questions you would like us to discuss on this podcast? Email us at ⁠caip@ifas.ufl.edu⁠. For more information and resources, visit our ⁠website⁠. Follow UF/IFAS CAIP on ⁠Instagram⁠, ⁠Facebook⁠, and ⁠Twitter⁠.

We start with Chopin's Prelude #16 in B-flat minor.The first day, we visited three lovely towns and eat our way through them.  These include:  Tricase Porto, where we ate really delicate seafood and a wonderful fennel cream soup.  The second day, we stayed in Lecce and visited a couple stores including a cheese store where we tasted squeaky nodoni.  That afternoon, we had an altercation with a local pigeon, who claimed rights to our pasticciotto.  On the third day, we visited Ostuni, the white city, and in the afternoon we drove back south to Gallipoli, a port with real character.  We had a fantastic seafood lunch and then witnessed thousand bemoaning the loss of one of the city's finest warriors who died in his mother's arms after choking on a meatball.  That was the theme of Gallipolli's Carnevale.I then talk about progress starting our new store, established and run by Projet Espoir et Equite, our French version of Project Hope and Fairness, whose goal is to build chocolate factories in villages and then develop markets for the chocolate.  The podcast finished with Bach's Prelude #22 in B-Flat Minor.Our successes are financially dependent.  Your donations ensure future success.  To donate, send a check to:Project Hope and Fairness1298 Warren RoadCambria, CA 93428. -OR-  go to projecthopeandfairness.org, pull down to Donate and follow the instructionsThank You!  Tom Neuhaus, CEO of Project Hope and Fairness

Siete mai stati ad un Carnevale? Noi oggi vi portiamo a Venezia e Viareggio, sedi di due feste molto importanti e famose in tutto il mondo!Support the show

Just one month on the job, newly elected MassGOP Chair Amy Carnevale said she's encouraged by the future, but is still sorting out the financial predicaments of the party.

This week, Maria shares a recipe for a traditional Venetian Frittelle! No matter what the season, you'll find an incredible story and recipe in - "The Basic Art of Italian Cooking Diaries: Seasons!" Enter, "The Maria Liberati Show," based on her travels, as well as her Gourmand World Award-winning book series, "The Basic Art of Italian Cooking," and "The Basic Art of..." Find out more on https://www.marialiberati.com ----- Intro music: "A Quick Coffee" by Borrtex - available via Creative Commons Attribution-ShareAlike 3.0 https://creativecommons.org/licenses/by-sa/3.0/us/ Outro music: "First Day of Spring" by David Hilowitz - available via Creative Commons Attribution-ShareAlike 3.0 https://creativecommons.org/licenses/by-sa/3.0/us/ --- Send in a voice message: https://anchor.fm/maria-liberati/message

Sign up to our newsletter here. Join our facebook group here or join our Discord here.You can physically send us stuff to PO BOX 7127, Reservoir East, Victoria, 3073.Want to help support the show?Sanspants+ | Shop | TeesWant to get in contact with us?Email | Twitter | Website | Facebook | RedditOr individually at;Hayden | CassShut Up a Second is hosted and produced by Cass Paige and Hayden Bleechmore.Recorded and produced on Wurundjeri land, we respectfully acknowledge the Wurundjeri People of the Kulin Nation, pay our respect to their Elders past and present, and recognise that sovereignty was never ceded. Hosted on Acast. See acast.com/privacy for more information.

21 febbraio 2023 - Italiano in Podcast. Episodio del Martedì Grasso, ultimo giorno di Carnevale. Il podcast ritorna dopo la pausa del lunedì e ritorna ancora una volta in video. L'inizio della settimana è stato molto pieno tra le lezioni e la realizzazione di una nuova intervista per "Quattro chiacchiere con....". La registrazione con Julie è andata bene nonostante qualche piccolo problema tecnico. In questo ultimo giorno di Carnevale ancora diverse lezioni e la scrittura di un nuovo articolo per il blog sul 150° Carnevale di Viareggio. La città toscana è uno dei luoghi più famosi al mondo per i suoi bellissimi carri allegorici e per i suoi lunghi festeggiamenti del periodo carnevalesco. In chiusura, dopo qualche notizia, la frase celebre con un proverbio di Viareggio come omaggio alla città e al suo famoso Carnevale. iSpeakItaliano vi saluta e vi da appuntamento al prossimo episodio di Italiano in Podcast. A presto! Abbonati per dare un contributo e ascoltare gli episodi speciali di Italiano in Podcast https://anchor.fm/ispeakitaliano/subscribe Supporta iSpeakItaliano su BuyMeACoffee Il negozio di iSpeakItaliano https://www.ispeakitaliano.it/merchandise/ Tutti i collegamenti del progetto iSpeakItaliano --- Send in a voice message: https://anchor.fm/ispeakitaliano/message

Oggi il gas è intorno ai 48 euro al megawattora, un prezzo che avrà una ricaduta diretta sulla bolletta di famiglie e imprese. Tra qualche giorno Arera comunicherà le nuove tariffe del gas sul mercato tutelato per il mese di febbraio. Se proseguirà fino a fine mese il trend al ribasso delle quotazioni, le bollette potrebbero registrare un sensibile calo, attorno al -18%. Ne parliamo con Davide Tabarelli, presidente Nomisma Energia. Auto, in Europa vendite su del 10,7% a gennaio Continua il recupero del mercato auto in Europa, con le immatricolazioni nell area (Unione europea più Efta e Gran Bretagna) che segnano a gennaio una crescita del 10,7% rispetto allo stesso periodo del 2022. Rispetto alla fase pre covid, però, i volumi restano inferiori del 25,7% ma l inversione di tendenza, iniziata nel mese di agosto, dopo 13 mesi consecutivi di cali, si sta consolidando. Grazie soprattutto al miglioramento delle condizioni di fornitura di semiconduttori e microchip e alla maggiore disponibilità di auto nuove sul mercato. In previsione dello stop alle vendite di veicoli a benzina o diesel dal 2035, va registrato un netto ritardo dell'Italia rispetto agli altri paesi europei. Secondo i dati di Unrae, pubblicati oggi, il nostro Paese resta ancora all'ultimo posto nella classifica delle immatricolazioni di auto ECV (elettriche pure e ibride plug-in): con una quota del 7,3% è superata ampiamente dalla Francia con il 22,3%, dal Regno Unito con il 20%, dalla Germania al 15,0%. Approfondiamo il temaGian Primo Quagliano, direttore generale Centro Studi Promotor. Turismo. Ci si aspetta un 2023 sopra i livelli pre covid. Nel 2023 potrebbero essere superati i livelli prepandemia del turismo in Italia. Lo ha detto Ivana Jelinic, amministratrice delegata dell'Enit, a margine dell'evento di mercoledì 15 febbraio nel quale è stato presentato il Progetto Pnrr "Turismo delle radici: una strategia integrata per la ripresa del settore del turismo nell'Italia Post Covid-19". Evento che ha visto la partecipazione dei ministri Tajani (Esteri), Santanché (Turismo), Valditara (Istruzione), Bernini (Università e Ricerca). "Nel 2022 - ha precisato l'a.d. Enit - siamo ancora sotto in maniera significativa, al di sotto del 10%, ma nel 2023 pensiamo ad un pieno recupero. Anche la ministra del Turismo Daniela Santanché ha ribadito ieri che si aspetta un ritorno ai numeri pre pandemia per quanto riguarda il turismo; "nel 2023 supereremo i dati pre-covid". Intanto il ponte di Carnevale si avvicina, CNA stima un giro di affari di quasi 3 miliardi di euro, ma la grande assente è la neve che scarseggia drammaticamente. A gennaio sono stati registrati livelli più bassi rispetto allo stesso mese del 2022. Ne parliamo con Ivana Jelinic, amministratrice delegata dell'Enit.

Qual è l'origine del Carnevale? Perché si festeggia in date diverse ogni anno? E da dove provengono le famose maschere di Carnevale? Nell'episodio di oggi risponderò a tutte queste domande, e conosceremo meglio alcune maschere molto famose, come Arlecchino, Colombina, Pantalone e altre ancora. _______ Le trascrizioni di tutti gli episodi del podcast sono disponibili sulla mia pagina Patreon: https://www.patreon.com/vaporettoitaliano Sul profilo Patreon di Vaporetto Italiano troverai: pdf con spiegazioni ed esercizi relativi ai video pubblicati su YouTube; le trascrizioni degli episodi del podcast con il lessico più importante (usato in contesto); cruciverba per memorizzare il lessico nuovo di ogni episodio; tante lezioni in diretta durante le quali parleremo, faremo attività di comprensione orale, quiz e molto di più! Con i materiali di Vaporetto Italiano potrai imparare l'italiano sempre di più e parlare in modo sempre più naturale. Sono felice di averti qui con me!

In this episode, Nathan shares a day filled with two very different experiences! Vera has a brilliant idea for her “La Vera Italia” segment which will quite literally transport you! Enjoy!

Dopo la pausa per il coronavirus, il Carnevale di Fremantle ritorna questa domenica con la sfilata, il carro delle maschere e concerti.

This week on Thumb Cramps it's a special FEBUAMECUBE direct special as Joel Duscher is unwell and we've had to call in the big guns to take over hosting. Plus we're joined by guest Adam Carnevale to look at The Nintendo Direct for the real life, Rusted Moss DEMO for the PC and Ghost Recon: Wildlands for the PC. Get well soon Joel Duscher. Email us at ThumbCrampsPod@gmail.com Find us on Twitter; Jackson | Duscher | Thumb Cramps | Adam Watch us on Twitch; Jackson | Duscher | Adam You can now physically send us stuff to PO BOX 7127, Reservoir East, Victoria, 3073.Join our facebook group here or join our Discord here. Theme music by Benny Davis! You can find all his stuff at his website or check out his YouTube channel. Hosted on Acast. See acast.com/privacy for more information.

This month on Episode 45 of Discover CircRes, host Cynthia St. Hilaire highlights four original research articles featured in the February 3rd and February 17th issues of Circulation Research. This episode also features an interview with Dr Hind Lal and Dr Tousif Sultan from the University of Alabama at Birmingham about their study Ponatinib Drives Cardiotoxicity by S100A8/A9-NLRP3-IL-1β Mediated Inflammation.   Article highlights:   Pi, et al. Metabolomic Signatures in PAH   Carnevale, et al. Thrombosis TLR4-Mediated in SARS-CoV-2 Infection   Cai, et al. Macrophage ADAR1 in AAA   Koide, et al. sEVs Accelerate Vascular Calcification in CKD   Cindy St. Hilaire:        Hi, and welcome to Discover CircRes, the podcast of the American Heart Association's journal, Circulation Research. I'm your host, Dr Cynthia St. Hilaire from the Vascular Medicine Institute at the University of Pittsburgh, and today I'm going to be highlighting the articles from our February 3rd and 17th issues of Circulation Research. I'm also going to have a chat with Dr Hind Lal and Dr Tousif Sultan from the University of Alabama at Birmingham about their study, Ponatinib Drives Cardiotoxicity by S100A8/A9-NLRP3-IL-1β Mediated Inflammation. But before I get to the interviews, here are a few article highlights.   Cindy St. Hilaire:        The first article I want to highlight comes from the laboratory of Dr Peter Leary at the University of Washington, and the title is Metabolomic Signatures Associated With Pulmonary Arterial Hypertension Outcomes. Pulmonary Arterial Hypertension or PAH is a rare but life-threatening disease in which progressive thickening of the walls of the lung's blood vessels causes increased blood pressure and that increased blood pressure ultimately damages the heart's right ventricle.   Interestingly, progression to heart failure varies considerably among patients, but the reasons why there is variability are not well understood. To find out, this group turned their attention to patient metabolomes, which differ significantly from those of healthy people and thus may also change with severity. Blood samples from 117 PAH patients were analyzed for more than a thousand metabolites by mass spectrometry and the patient's progress was followed for the next three years. 22 patients died within a three-year period and 27 developed significant right ventricle dilation. Other measures of severity included pulmonary vascular resistance, exercise capacity and levels of BNP, which is a metric of heart health. Two metabolic pathways, those relating to polyamine and histidine metabolism, were found to be linked with all measures of severity suggesting a key role for them in disease pathology. While determining how these pathways influence disease as a subject for further study, the current findings may nevertheless lead to new prognostic indicators to inform patient care.   Cindy St. Hilaire:        The next article I want to discuss is coming from our February 3rd issue of Circulation Research and this is coming from the laboratory of Dr Francisco Violi at the University of Rome and the title is Toll-Like Receptor 4-Dependent Platelet-Related Thrombosis in SARS-CoV-2 Infection. Thrombosis can be a complication of COVID-19 and it is associated with poor outcomes, including death. However, the exact mechanism by which the virus activates platelets, which are the cells that drive thrombosis, is not clear. For one thing, platelets do not appear to express the receptor for SARS-CoV-2. They do however, express the TLR4 receptor and that's a receptor that mediates entry of other viruses as part of the immune response. And TLR4 is ramped up in COVID-19 patient platelets. This group now confirms that, indeed, SARS-CoV-2 interacts with TLR4, which in turn triggers thrombosis.   The team analyzed platelets from 25 patients and 10 healthy controls and they found that the platelet activation and thrombic activity were both boosted in the patient samples and could not be blocked using a TLR4 inhibitor. Additionally, immunoprecipitation and immunofluorescent experiments further revealed colocalization between the virus protein and the TLR4 receptor on patient platelets. The team went on to show that the signaling pathway involved reactive oxygen species producing factors p47phox and Nox2, and that inhibition of phox 47, like that of the TLR4 receptor itsel,f could prevent platelet activation. As such, this study suggests that inhibiting either of these proteins may form the basis of an antithrombotic treatment for COVID-19.   Cindy St. Hilaire:        The third article I want to highlight is coming from the lab of Shi-You Chen at University of Missouri and the title of this article is ADAR1 Non-Editing Function in Macrophage Activation and Abdominal Aortic Aneurysm. Macrophage activation plays a critical role in abdominal aortic aneurysm development, or AAA development. Inflammation is a component of this pathology; however, the mechanisms controlling macrophage activation and vascular inflammation in AAA are largely unknown. The ADAR1 enzyme catalyzes the conversion of adenosine to inosine in RNA molecules and thus this conversion can serve as a rheostat to regulate RNA structure or the gene coding sequence of proteins. Several studies have explored the role of ADAR1 in inflammation, but its precise contribution is not fully understood, so the objective of this group was to study the role of ADAR1 in macrophage activation and AAA formation.   Aortic transplantation was conducted to determine the importance of nonvascular ADAR1 in AAA development and dissection and angiotensin II infusion of ApoE knockout mice combined with a macrophage specific knockout of ADAR1 was used to study the role of ADAR1 macrophage specific contributions to AAA formation and dissection. Allograft transplantation of wild type abdominal aortas to ADAR1 haploinsufficient recipient mice significantly attenuated AAA formation. ADAR1 deficiency in hematopoietic stem cells also decreased the prevalence and the severity of AAA and it also inhibited macrophage infiltration into the aortic wall. ADAR1 deletion blocked the classic macrophage activation pathway. It diminished NF-κB signaling and it enhanced the expression of a number of anti-inflammatory microRNAs. Reconstitution of ADAR1 deficient but not wild type human monocytes to immunodeficient mice blocked the aneurysm formation in transplanted human arteries. Together these results suggest that macrophage ADAR1 promotes aneurysm formation in both mouse and human arteries through a novel mechanism of editing the microRNAs that target NF-κB signaling, which ultimately promotes vascular inflammation in AAA.     Cindy St. Hilaire:        The last article I want to highlight is also from our February 17th issue of Circulation Research and it is coming from the lab of Shintaro Mandai at Tokyo Medical and Dental University and the title of the article is Circulating Extracellular Vesicle Propagated MicroRNA signatures as a Vascular Calcification Factor in Chronic Kidney Disease. Chronic Kidney Disease or CKD accelerates vascular calcification in part by promoting the phenotypic switching of vascular smooth muscle cells to osteoblast like cells. This study investigated the role of circulating small extracellular vesicles or SUVs from the kidneys in promoting this osteogenic switch. CKD was induced in rats and in mice by an adenine induced tubular interstitial fibrosis and serum from these animals induced calcification in in vitro cultures of A-10 embryonic rat smooth muscle cells. Intraperitoneal administration of a compound that prevents SEV biosynthesis and release inhibited thoracic aortic calcification in CKD mice under a high phosphorus diet. In Chronic Kidney Disease, the microRNA transcriptome of SUVs revealed a depletion of four microRNAs and the expression of the microRNAs inversely correlated with kidney function in CKD patients.   In vitro studies found that transected microRNA mimics prevented smooth muscle cell calcification in vitro. In silico analyses revealed that VEGF-A was a convergent target of all four microRNAs and leveraging this, the group used in vitro and in vivo models of calcification to show the inhibition of the VEGF-A, VEGFR-2 signaling pathway mitigated calcification. So in addition to identifying a new potential therapeutic target, these SUV propagated microRNAs are a potential biomarker that can be used for screening patients to determine the severity of CKD and possibly even vascular calcification.   Cindy St. Hilaire:        Today I have with me Dr Hind Lal who's an associate professor of medicine at the University of Alabama Birmingham and his post-doctoral fellow and the lead author of the study Dr Tousif Sultan. And their manuscript is titled Ponatinib Drives Cardiotoxicity by S100A8/A9-NLRP3-IL-1β Mediated Inflammation. And this article is in our February 3rd issue of Circulation Research. So thank you both so much for joining me today.   Tousif Sultan:              Thank you.   Hind Lal:                     Thank you for taking time.   Cindy St. Hilaire:        So ponatinib, it's a tyrosine kinase inhibitor and from my understanding it's the only treatment option for a specific group of patients who have chronic myelogenous leukemia and they have to harbor a specific mutation. And while this drug helps to keep these patients alive essentially, it's extremely cardiotoxic. So cardiotoxicity is somewhat of a new field. So Dr Lal, I was wondering how did you get into this line of research?    Hind Lal:                    So I was fortunate enough to be in the lab of Dr Tom Force and he was kind of father of this new area, now is very developed, it's called cardio-oncology. On those days there were basically everything started in cardio-oncology. So I just recall the first tyrosine kinase approved by FDA was in 2000 and that was... Imagine and our paper came in Nature Medicine 2005 and discovering there is... so to elaborate it a little bit, the cancer therapy broadly divided in two parts. One is called non-targeted therapy like chemotherapy, radiations, et cetera, and then there are cytotoxic drugs. So those cytotoxic drugs because they do not have any targeted name on it so they are, cardiotoxic are toxic to any organ was very obvious and understanding. When these targeted therapy came, which is mainly kinase inhibitor are monoclonal antibodies. So these are targeted to a specific pathway that is activated only in the cancer cells but not in any other cells in the body so they were proposed as like magic bullets that can take off the cancer without any cardiotoxity or minimal side effects. But even in the early phase like 2005 to 2010, these came out, these so-called targeted, they are not very targeted and they are not also the magic bullets and they have serious cardiotoxicity.   Cindy St. Hilaire:        And so what's the mechanism of action of ponatinib in the leukemia and how does that intersect with the cardiovascular system?   Hind Lal:                     Yeah, so this is very good question I must say. So what we believe at this point because, so leukemia if you know is driven by the famous Philadelphia chromosome, which is a translicational gene, one part of human chromosome nine and one part of human chromosome 22 and they translocate make a new gene which is BCR-ABL gene. And because it was discovered in Philadelphia UPENN, is named that Philadelphia chromosome, which is very established mechanism, that's how CML is driven. But what we have discovered that the cardiotoxicity driven by totally, totally different from the ponatinib is one of the inflammatory So it's kind of goodening. So this question is so good. One kind of toxicity is called on-target, when toxicity is mediated by the same mechanism, what is the mechanism of the drug to cure the cancer? So in that case your absolute is minimal because if you manipulate that, the drug's ability to cure the cancer will be affected but if the toxicity and the efficacy is driven by two different mechanism, then as in case of ponatinib seems like it's NLRP3 and inflammasome related mechanism. So this can be managed by manipulating this pathway without hampering the drug efficacy on the cancer.   Cindy St. Hilaire:        So what exactly is cardiotoxicity and how does it present itself in these patients?   Hind Lal:                     So these drugs like ponatinib, they call broader CVD effects. So it's not just cardiac, so they also in hypertensives and atherosclerosis and thrombosis, those kind of thing. But our lab is primarily focused on the heart. So that's why in this paper we have given impresses on the heart. So what we believe at this point that ponatinib lead to this proinflammatory pathway described in this paper, which is just 108A9-NLRP3-IL-1β and this inflammatory pathway lead to a cytokine storm very much like in the COVID-19 and these cytokine storms lead to excessive myocarditis and then finally cardiac dysfunction.   Cindy St. Hilaire:        Is the cytokine storm just local in the cardiac tissue or is it also systemic in the patients? Is cardiotoxicity localized only or is it a more systemic problem?   Tousif Sultan:              I would like to add in this paper we have included that we look this cytokine things and explain blood circulation, bone marrow. So the effect is everywhere, it's not local. So we didn't check other organs, maybe other organs also being affected with the ponatinib treatment.   Cindy St. Hilaire:        And what's the initial phenotype of a patient has when they start to get cardiotoxicity, what's kind of like a telltale symptom?   Hind Lal:                     So good thing that in recent years cardio-oncology developed. So initially the patient that were going for cancer treatment, they were not monitored very closely. So they only end up in cardiology clinic when they are having some cardiac events already. So thanks to the lot of development and growth in the cardio-oncology field, now most patients who going for a long-term cancer treatment, they are closely monitored by cardiology clinics.   Cindy St. Hilaire:        Got it. So they can often catch it before a symptom or an event. That's wonderful.   Hind Lal:                     Yeah, so there's a lot of development in monitoring.   Cindy St. Hilaire:        Wonderful. So you were really interested in figuring out why ponatinib induces cardiotoxicity and you mentioned that really up until now it's been very difficult to study and that's because of the limitation of available murine models. If you just inject a wild type mouse with ponatinib, nothing happens really. So what was your approach to finding relatively good murine models? How did you go about that?   Hind Lal:                     So this is the top scientific question you can ask. So like science, the field is try and try again. So initially this is the first paper with the ponatinib toxicity using the real in vivo models. Any paper before this including ours studies published, they were done on the cellular model in hiPSC, that isolated cardiomyocytes. So you directly putting the ponatinib directly the isolated cells. So this is first case when we were trying to do in vivo, maybe other attempt in vivo but at least not published. So first we also treated the animals with ponatinib and that failed, we don't see any cardiotoxic effect. And then when we going back to the literature, the clinical data is very, very clear from pharmacovigilance that ponatinib is cardiotoxic in humans. So when we're not able to see any phenotype in mouse, we realize that we are not mimicking what's happening in the humans.   So we certainly missing something. Now once again I quote this COVID-19, so many people get infected with COVID-19 but people are having preexisting conditions are on high risk to developing CVD. So there was some literature on that line. So we use this very, very same concept that if there is preexisting conditions, so likely who'd have developing future cardiac event will be more. So we use two model in this paper one atherosclerosis model which is APoE null mice mice, another is tag branding which is pressure overload model for the heart and as soon as we start using what we call comorbidity model like patient is having some preexisting conditions and we very clearly see the robust defect of ponatinib on cardiac dysfunction.   Cindy St. Hilaire:        Yeah, it's really, really well done and I really like that you use kind of two different models of this. Do you think it's also going to be operative in maybe like the diabetic mirroring models? Do you think if we expand to other comorbidities, you might also recapitulate the cardiotoxicity?   Hind Lal:                     So you got all the best questions.   Cindy St. Hilaire:        Thank you. I try.   Hind Lal:                     So because this is CML drug and lot of the risk factor for cardiovascular and cancer are common and even metabolic disease. So most of the time these patients are elderly patients and they're having metabolic conditions and most of the time they have blood pressure or something CVD risk factors. So I agree with you, it'll be very relevant to expand this to the diabetes or metabolic models, but these were the first study, we put all our focus to get this one out so news is there then we can expand the field adding additional models et cetera. But I agree with you that will be very logical next step to do.   Cindy St. Hilaire:        Yeah. And so I guess going back to what you know from the human study or the clinical trials or the human observations, are different populations of patients with CML more predisposed to cardio toxicity than others or is that not known yet?   Hind Lal:                     So one other area called pharmacovigilance. So what pharmacovigilance does patient all over the world taking these drugs. So WHO have their own vigilance system and FDA have their own, so it's called BG-Base for the WHO and it's called the FAERS for the FDA. So one can go back in those data sets and see if X patient taking this Y drug and what kind of symptoms or adverse effect they are seeing and if these symptoms are associated with something else. So there is data that if patients having CVD risk factor, they are more prone to develop ponatinib induced cardiac events. But it needs more polish like you asked the just previous question, diabetes versus maybe blood pressure means hypertension, atherosclerosis, or thrombosis. So it has not been delineated further but in a one big bucket if patients are having CVD risk factor before they are more prone and more likely to develop the cardiac events.   Cindy St. Hilaire:        So after you established that these two murine models could pretty robustly recapitulate the human phenotype, what did you do next? How did you come upon the S100A8/A9-NLRP3-IL-1β signaling circuit? How did you get to that?   Hind Lal:                     So in basic science work, whenever we do mouse is called until we get there is cardiac dysfunction, it's called phenotype, right? So mouse had a cardiac phenotype. So next step is, "Why? What is leading to that phenotype?" That's what we call mechanism. So there the best idea to fit the mechanism is using one of the unbiased approaches like you do unbiased proteomics, unbiased RNC analysis, something like this that will analyze the entire transcript like RNC and say, "Okay, these pathway are," then you can do further analysis that will indicate these pathway are different, are altered. So in this case we used RNC analysis and it came out that this yes A8 and yes A9, 100A8 and nine, they were the most upregulated in this whole set. And thereafter we were very lucky. So we started this study at Vanderbilt, where my lab was and thereafter we very lucky to move here and found Sultan who had a lot of experience with this inflammation and immune system and then Sultan may add something on this so he'll be the better person to say something on this.   Tousif Sultan:              So after our RNC analysis, so we got this S100A8 and nine as top hit with the ponatinib treatment. So then we validated this finding with our flow cytometric, qRT PCR aand then we started which pathway is going to release cytokine and all that. So we found that is NLRP3 inflammasome.   Cindy St. Hilaire:        Yeah and well and I guess maybe step back, what is S100A8/A9? What are those? Tousif Sultan:              Yeah, S10A8/A9 is a calcium binding protein. So that's also called alarmin and they basically binds with the pathogen associated pattern and other TLR2 like receptors and then start inflammatory pathway to release cytokine and all that and it's stable in heterodimer form. So S100A8 heterodimer with A9 and then bind with TLR and a start in this inflammatory pathway.   Cindy St. Hilaire:        And what type of cell is that happening in? Is that happening in the immune cells only or is it also in the cardiomyocyte, or...?   Tousif Sultan:              Yeah, we have included all this data. So from where this alarmin is coming with ponatinib treatment, so literature also suggested that neutrophils and monocytes, those cells are the potential to release the alarmin. So here we also found these two type of cells, neutrophils and monocytes. They release huge alarmin with the treatment of ponatinib.   Cindy St. Hilaire:        And so really taking this really neat mechanism to the next level, you then tried attenuating it by using broad anti-inflammatory steroid dexamethasone but also by targeting these specific components, the NLRP and the S100A specific inhibitors and they worked well. It worked really nicely. Does your data show that any of these therapies work better than the other and then are these viable options to use in humans?   Hind Lal:                     Yeah, we have some data in the paper. Are very broad which help a lot in COVID patients, far very acute infections. So in this case, situation is very different cause most of CML patients will going to take ponatinib for lifelong, there is no remission, right? So in those case, its certainly not a very attractive option. We have shown data in the paper that dexamethasone help with the heart but lead to some metabolic changes. So we have compared those with the NLRP3 inhibitors, those metabolic alterations, dexa versus the NLRP3 inhibitors, CY-09. And we demonstrated that targeting is specifically with paquinimod, our NLRP3 inhibitor CY-09, feel better. It can still rescue the cardiac phenotype without having those adverse effect on metabolic parameters.   Cindy St. Hilaire:        That's wonderful. Do you think though that because you have to take ponatinib for life, that long-term NLRP inhibition would also cause problems or...?   Hind Lal:                     So because not every patient who taking ponatinib would develop the cardiac phenotype, right? Which is like a 10%, 12%, patient developing cardiac dysfunction. So I think someone like I strongly believe paquinimod, which is inhibitor of S100A9, will be really good option or at least we have enough data that make us nail for at least a small clinical trial. And we quickly moving on that. At UAB we have our clinical cardio-oncology program and we are already in touch with the director for the clinical cardio-oncology program. So what we trying to do in that small trial is if one of the standard therapy for heart like beta blocker or ARBs inhibitor, is there any preference like one work better than the other in the standard care? So first we doing that project, then we obviously looking forward if one small clinical trial can be done with paquinimod. I strongly believe it should be helpful.   Cindy St. Hilaire:        That is wonderful. And so do you think... There's other chemotherapeutic agents or probably even other non-cancer drugs that cause cardiotoxicity, do you think this mechanism, this pathway, this S100A-NLRP-IL-1β axis is operative in all cardiotoxicities or do you think it's going to be very specific to the ponatinib?   Hind Lal:                     So it's certainly not all, but it'll be certainly more than ponatinib. So in our lab we are using another kinase inhibitor, which is osimertinib and it's not published yet, but now we know that it's also cardiotoxic because it's taking metabolic root or energetics disruption but not this pro-inflammatory part, but we're doing another project which is strep pneumonia induced cardiac dysfunction, which is called pneumonia. So strep pneumoniae, which leads to the pneumonia ,and lot patient die because of the failing heart we see here in the hospitals and we see these pathways operational over there and we gearing up to do clinical trial on that aspect as well, but it's not generalized like all kind of heart will have the same mechanism.   Cindy St. Hilaire:        It's wonderful to see you're already taking those next steps towards really kind of bringing this to a translational/clinical study. So what was the most challenging aspect of this study?   Tousif Sultan:              The challenging aspect, ponatinib is a kinase inhibitor and that was surprising for us how it's activating immune cells. Generally kinase inhibitors, inhibits all the cells like that. So that was challenging. So we repeated it many times did in vitro experiment to confirm that. So we just added, just treated in vitro immune cells with the ponatinib and confirmed it. So that was little challenging.   Cindy St. Hilaire:        So what's next? You mentioned you're going to try some clinical trials, early stage clinical trials. What's next mechanistically, what do you want to go after?   Hind Lal:                     So what we are doing next and we are very, very eagerly trying to do that. So what it was done, we used the cardiac comorbidity models, but as you know, anybody who will take ponatinib will have cancer, right? So we strongly believe that we miss one factor. There was no cancer on these. So that is very logical next step. What that will allow us to do, what rescue experiment we'll have done in this paper. So we saw, "Okay, this rescue the cardiac phenotype, which is taken care of now," but very same time, we not able to demonstrate that this is happening without hurting the cancer efficacy. So if we have the dual comorbid mouse, which have CML a real thing and we have cardiac thing, then that will allow us to demonstrate, "Okay, we got something that can take care of the cardiac problem without hurting the efficacy on the cancer." And it will be best if you also help little bit to more potentiate the cancer efficacy.   Cindy St. Hilaire:        Yes. Excellent. Well, congratulations on a beautiful study, really exciting findings. Dr Lal and Dr Sultan, thank you so much for taking the time to talk with me today.   Tousif Sultan:              Thank you so much.   Hind Lal:                     Well thank you, Cynthia. We really appreciate your time. Thank you for having us.   Cindy St. Hilaire:        Yeah, it was great.   Cindy St. Hilaire:        That's it for our highlights from the February 3rd and February 17th issues of Circulation Research. Thank you so much for listening. Please check out the Circulation Research Facebook page and follow us on Twitter and Instagram with the handle @CircRes and #DiscoverCircRes. Thank you to our guests, Dr Hind Lal and Dr Tousif Sultan. This podcast is produced by Ishara Ratnayake, edited by Melissa Stoner and supported by the editorial team at Circulation Research. Some of the copy text for the highlighted articles was provided by Ruth Williams. I'm your host, Dr Cynthia St. Hilaire, and this is Discover CircRes, you're on-the-go source for most exciting discoveries in basic cardiovascular research. This program is copyright of the American Heart Association 2023. And the opinions expressed by the speakers in this podcast are their own and not necessarily those of the editors or of the American Heart Association. For more information, please visit ahajournals.org.  

Martedì grasso si avvicina e allora in questa puntata parliamo di Carnevale! Come mai si chiama Carnevale? Chi ha inventato i coriandoli? Quali sono i dolci tipici di carnevale? Scopri queste e altre curiosità sul carnevale con Katia e Alessio!Segui il nostro podcast sulla lingua italiana "Italiano ON-Air" su: https://podcast.scuolaleonardo.com (dove trovi anche la trascrizione dell'episodio)oppure sulle principali piattaforme di podcast:Apple Podcasts | Spotify | Amazon Music | Google PodcastPer informazioni sui corsi della Scuola Leonardo da Vinci:  www.scuolaleonardo.com----------- ENGLISH ------------We are in the carnival season, and Martedì Grasso (Shrove Tuesday) is coming. In this episode, Katia and Alessio will tell you why it's called "Carnevale", who invented the Coriandoli (Confetti), and other curiosities about the carnival!Follow our podcast on the Italian language "Italiano ON-Air"  by Scuola Leonardo da Vinci: https://podcast.scuolaleonardo.com (where you can find the transcript of the episode) or on the leading podcast platforms:Apple Podcasts | Spotify | Amazon Music | Google PodcastFor information on the Scuola Leonardo da Vinci courses:  www.scuolaleonardo.com

See pictures and read more on materiallyspeaking.comCarnevale originated in pagan rituals celebrating winter turning to spring. For Christians it offers a brief hiatus before the rigours of Lent – hence the name ‘carnem levare' – which means ‘to take away meat'. This is a time to create chaos, to question and poke fun at authority and, for the artisans of Viareggio, the opportunity to say something meaningful to the public and get them involved.La Cittadella del Carnevale, just outside Viareggio, is a circular complex with 16 hangar-like warehouses and a museum. It's here that we meet some of the artisans whose dizzying array of skills include design, art, modelling, mechanics, puppetry, welding, choreography and scenography. However, as in a circus, everyone has to do a bit of everything.— — —The French Lebigre family travelled the world learning from other carnivals, and are credited with being the first to create a community theatre to perform in front of their floats. Each year they train 200 people from all walks of life to participate in their show. This year their grand float is entitled Laugh Pagliaccio, or the art of taking oneself seriously and features a clown looking at himself in the mirror as he readies himself for the show. Will he make us all laugh, or himself be the one to laugh at the world which has become a circus?— — —Libero Maggini is an artist based in Pietrasanta who creates works in bronze, terracotta and marble. He is the son of two artists and each winter he works with his father at the Carnevale. This year, the 150th anniversary of the carnival, they created six figures for the masquerade category as a homage to Queen Elizabeth II and her dogs. It is titled Anglicani as a joke – ‘cani' means dog in Italian.— — —Edoardo Ceragioli started competing in the Carnevale in 1998. This year his creation is titled There was a boy like me, which quotes a famous song by Gianni Morandi denouncing the stupidity of war. His creations depict memories of a young boy's life cut short in the rubble. Here you can see him working on the backpack representing the boy's schoolboy years.Francesco Manfré has been assisting Edoardo for some years and works as a lifeguard in Viareggio during the summer months. — — —Matteo Raciti was born in Sicily and grew up in the artistic community of the Carnevale of Acireale studying architecture before coming to Pietrasanta to train as a sculptor with a special interest in puppetry. This year he called his masquerade Humanity has lost the thread, a modern retelling of the Ariadne and the minotaur myth. His minotaurs can't get out of the labyrinths that our society has created. Will they be able to follow the red thread invented by a young Ariadne and find their way to a new humanity?Here you can see him working with a colleague placing papier-mâché inside a mould.

Tim & John broadcast from the Podcast Pavilion at AHR and welcome guests Bruce Carnevale, president and CEO, Bradford White and Randy Roberts, Vice President,  Sales & Marketing, Rheem. Bruce talks inflation, Chinese balloons, our potential over-reliance on China and Bradford White's commitment to the contractor. Randy talks install date standards, supply chain stuff, cautious optimism and how Rheem is positioning itself to be stronger when the economy amps back up.#appetiteforconstructionpodcast #appetiteforconstruction #mechanicalhub #plumbingperspective #supportthetrades #plumbing #hvac #trades #ahrexpo #ahr2023 #ahrexpo2023 #americastrong #chineseballoons #economy #supplychain #inflation #inflationreduction #chinaSubscribe to the Appetite for Construction podcast at any of your favorite streaming channels.Follow Plumbing Perspective @plumbing_perspectiveVisit our website: www.mechanical-hub.comSign up for our newsletter: https://mechanical-hub.com/enewsletter/

It's already February, and with February comes Carnival! Do you know how we celebrate it in Italian? And what about the food we eat during this event? If not (but even if you do), try listening to this episode! You'll learn lots of expressions related to Carnival, and you'll probably discover a couple cities that you'll absolutely want to visit this month! INSTAGRAM: https://www.instagram.com/sub_ita17/ WEBSITE: https://subtitleditalian.wixsite.com/learnitalian 1-TO-1 LESSONS ON ITALIKI: https://teach.italki.com/teacher/5288041 MORE ABOUT ITALIAN MASCHERE: https://maestramary.altervista.org/carnevale-maschere-tradizione.htm KO-FI: https://ko-fi.com/subtitleditalian/commissions --- Send in a voice message: https://anchor.fm/subtitleditalian/message

Mini corso Gratuito - Le 7 Regole di Italiano Automatico: https://italianoautomatico.lpages.co/corso-gratuito-le-7-regole-di-italiano-automatico/ In questo video imparerai le 7 parole più utili e comuni da usare durante il Carnevale. Queste parole sono usate ogni anno dagli italiani nel periodo di Carnevale e non solo. Preparati quindi ad arricchire il tuo lessico con tante nuove parole italiane che ti aiuteranno ad aumentare il tuo livello di italiano.Imparare i vocaboli più usati in italiano è un passo importantissimo da fare se vuoi parlare e padroneggiare l'italiano.Capitoli del podcast:0:00 Introduzione1:38 Carnevale2:16 Coriandoli3:58 Stelle filanti4:50 Maschera5:41 Costume6:49 Chiacchiere8:37 Carri mascherati10:56 Conclusione

6 febbraio 2023 - Italiano in Podcast. Lunga pausa causa pigrizia, poca energia e freddo! Un breve riassunto di questi giorni di fine settimana e poi qualche notizia. Siamo entrati nel Carnevale ma anche nella settimana di San Remo. Per chiudere una frase celebre proprio sul Festival della musica più importante d'Italia. Scusate il ritardo e a prestissimo con iSpeakItaliano e il prossimo episodio di Italiano in Podcast. Abbonati per dare un contributo e ascoltare gli episodi speciali di Italiano in Podcast https://anchor.fm/ispeakitaliano/subscribe Supporta iSpeakItaliano su BuyMeACoffee Il negozio di iSpeakItaliano https://www.ispeakitaliano.it/merchandise/ Tutti i collegamenti del progetto iSpeakItaliano --- Send in a voice message: https://anchor.fm/ispeakitaliano/message

Febbraio è il mese di tre appuntamenti "obbligati" e praticamente irrinunciabili per gran parte degli italiani: il primo evento imperdibile o comunque inaggirabile è il festival di Sanremo, che comincia oggi e finisce sabato 11, poi giusto qualche giorno di respiro ed ecco che il 14 arriva San Valentino, la festa degli innamorati, come non festeggiarla? Passata la festa degli innamorati avremo appena una settimana di tempo per preparare le maschere e i vestiti per adulti e piccini per il martedì grasso e le feste di Carnevale. Dopo questo tour de force accoglieremo la Quaresima come una liberazione. Oggi vogliamo sottoporre un referendum ai nostri ascoltatori a cui chiediamo se vogliono abolire almeno uno di questi tre eventi.

Jim was born and raised in Geneva, New York.  After graduating from college, he moved to Washington DC where he worked with the Federal Government as an architect.  He took early retirement from the Department of Justice in 2003. When his retirement was approved, he sent a message to the staff that said “There is a rumor going around that I'm retiring. I want you all to know that it's true and tomorrow is my last day.” Rod was born and raised in Greenville, South Carolina.  After graduating from college, he moved to Washington DC, and worked as a member of The United States Army Band, retiring from the Army in 1993.  He continued working as a school band director and finally retired in 2016.They have been together for nearly 43 years after meeting in Washington DC in 1980. They quickly decided that the relationship was going to be something special and two months after meeting they decided that their cats should meet each other too and they should merge households. Jim still quips that Rod was the “one night stand who never went home.” They were married in Skaneateles New York in 2011. Upon Jim's retirement and after 30 years in Washington DC, they moved to Placitas, New Mexico, where Jim used his architectural skills to design their spectacular retirement home in the desert.    While enjoying New Mexico, in time they began to realize just how much they missed the urban life that they knew from their years in DC.  Also, after many years of discussing a possible move to a more urban environment in Italy, they made the decision to move to Lucca.  Five years later they are solidly settled into life in Italy.LuccaCity in Tuscany, ItalyQuick factsLucca is a city and comune in Tuscany, Central Italy, on the Serchio River, in a fertile plain near the Ligurian Sea. The city has a population of about 89,000, while its province has a population of 383,957. WikipediaCounty: LuccaPopulation: 89,346Altitude: 19 mSupport the showIf you enjoy these podcasts, please make a donation by clicking the coffee cup on any page of our website www.wheredogaysretire.com. Each cup of coffee costs $5 and goes towards bringing you these podcasts in the future.

On Tuesday night, the State Republican Committee narrowly voted (37-34) to replace two-term chairman Jim Lyons with Washington lobbyist Amy Carnevale of Marblehead. She will serve a two-year term as chair.

2/1/23 6am CT Hour John, Glen and Sarah chat about Tyrie Nicols funeral, Pope Francis in Congo and the creator of Peeps candy. Damon shares research that proofs the best way to start a marriage is in your 20's without living together. Ashley reports on Pope Francis' trip to Congo, celebrations of Carnevale in Italy  and much more. Chadd explains the debt ceiling, what it means and what we can expect from congress.

Smithsonian communists declared a "neutral zone" against pro-lifers this January, which we know means an Orwellian zone. Then, Howie welcomes to the show the MA GOP's next Chairwoman, Amy Carnevale. Carnevale bested Jim "Jones" Lyons last night in the second round of the state committee election. All this plus the Chump Line, so tune in!

Amy Carnevale is a lifelong Republican who was born and raised in Massachusetts. She attended George Washington University while she worked in the White House part-time and went on to work on Capitol Hill as Rep. George Nethercutt's Chief of Staff. Carnevale is now running for Massachusetts Republican Party Chair and joined Dan to discuss.

In this episode called "Il FantaSanremo", I talk about the trend of the moment: more and more Italians are getting into this virtual game, called FantaSanremo, indeed. If you want to know more about it, keep listening to this article! :)If you need the script click here:You might be interested in:Il Festival di Sanremo:- audio: https://www.spreaker.com/episode/22370307- script: https://ilazed.com/2019/02/03/il-festival-di-sanremo-la-sfida-tra-i-cantanti-italiani/Il Carnevale in Italia:- audio: https://www.spreaker.com/episode/22690537- script: https://ilazed.com/2020/02/08/le-maschere-di-carnevale/Le maschere di Carnevale:- audio: https://www.spreaker.com/episode/22545490- script: https://ilazed.com/2019/02/23/il-carnevale-popolare-festa-italiana/__________________________________Read more about the Italian language and culture!!https://ilazed.com___________________________Follow me on my socials:https://www.facebook.com/italianwithilazed/https://www.instagram.com/ila_zed/https://twitter.com/ila_zedhttps://www.pinterest.it/ilalazed/_____________________________Do you want to learn Italian with me?You can find me on:- www.ilazed.com- www.lingoci.com- www.languatalk.com

Il professore Alessandro Barbero ha concesso l'intervista a favore del progetto "La Festa dello Scarlo" libro e documentario, produzione Masterblack di Andry Verga, edizione Atene del Canavese.L'intervista è inserita nel documentario dedicato allo Storico Carnevale di Ivrea; “La Festa dello Scarlo” è una festa che è allo stesso tempo storia, cultura, identità collettiva e momento di grande aggregazione e solidarietà. Il documentario affianca storia e antropologia (con interviste a Alessandro Barbero, Piercarlo Grimaldi, Claudio Tarditi e Franco Quaccia solo per citare alcuni degli studiosi coinvolti. Un racconto per testo e immagini di un evento che ogni anno si ripresenta, sempre uguale ma sempre nuovo, un rito della natura che al passo del tempo è diventato rito della cultura. Partecipare all'evento: https://www.atenedelcanavese.it/lafestadelloscarlo/ Fonte: https://www.youtube.com/watch?v=MPpOfGsNqqo Si ringrazia Andry Verga per la gentile concessione. ---// Disclaimer //Tutti gli audio disponibili sono utilizzati negli episodi dopo previo consenso e accordo con i distributori originali di altre piattaforme e/o comunque distribuiti liberamente e originariamente con licenze CC BY 4.0 e affini - o registrati in loco, viene sempre riportata la fonte. I titoli potrebbero differire in caso di titoli originali troppo lunghi.Per qualsiasi dubbio o problema contattateci PER FAVORE prima alla nostra mail: flamsteed46[@]gmail[dot]com

Scott MacDonald's Star Trek Career, Part 2 Scott MacDonald returns with more stories from his Star Trek career. Last time, we discussed his first role in the franchise and ever on TV as Tosk in the first season Star Trek DS9 episode "Captive Pursuit," the Romulan named N'Vek in the sixth season TNG episode "Face of the Enemy," and Gowron's brother in the "Star Trek: Klingon" PC game. This time, we learn about his time as Rollins on the pilot episode of "Star Trek: Voyager," who was supposed to have a more prominent role in the series. Scott was there with the original Captain Janeway, Geneviève Bujold, and explains what went wrong with her on set and how things immediately changed when Kate Mulgrew stepped in to take over. After that, we learn about his crazy audition story of he got the Goran'Agar role in the DS9 episode "Hippocratic Oath," working with Alexander Siddig and Colm Meaney while being directed by Rene Auberjonois covered in Jem'Hadar makeup and a wonderful tale about an act of kindness from the entire DS9 crew. Finally, it's all about the evil Xindi Commander Dolim from many episodes in season 3 of "Star Trek: Enterprise," including his makeup, working with Randy Oglesby, who Scott worked with previously in an award-winning play, having a fist fight with Scott Bakula in the season three finale, and how he ate the mouse! Enterprise fans – you know the scene! Plus, all about the modern horror Christmas classic "Jack Frost," his time on "Carnevale," a great tale about David Warner, and Scott takes a look at his Star Trek action figures! Visit fullempirepromotions.com to pick up signed items from Scott MacDonald from Star Trek and his other movies. Please subscribe to our brand new YouTube channel: www.youtube.com/@trekuntold . There you will see all the old episodes of this show, as well as new episodes and all of our other content, including shorts and some other fun things planned for the future. Visit my Amazon shop to check out tons of Trek products and other things I enjoy - https://www.amazon.com/shop/thefightnerd View the Teespring store for Trek Untold gear & apparel - https://my-store-9204078.creator-spring.com Support Trek Untold by becoming a Patreon at Patreon.com/TrekUntold. Don't forget to subscribe to the show and leave a rating if you like us! Follow Trek Untold on Social Media Instagram: http://www.instagram.com/trekuntoldTwitter: https://www.twitter.com/trekuntoldFacebook: https://www.facebook.com/trekuntold Follow Nerd News Today on Social Media Twitter:  Twitter.com/NerdNews2Day Instagram: Instagram.com/NerdNewsToday Facebook: Facebook.com/NerdNewsToday Trek Untold is sponsored by Treksphere.com, powered by the RAGE Works Podcast Network, and affiliated with Nerd News Today.   The views expressed on air during Trek Untold do not represent the views of the RAGE Works staff, partners, or affiliates. 

Scott MacDonald returns with more stories from his Star Trek career. Last time, we discussed his first role in the franchise and ever on TV as Tosk in the first season Star Trek DS9 episode "Captive Pursuit," the Romulan named N'Vek in the sixth season TNG episode "Face of the Enemy," and Gowron's brother in the "Star Trek: Klingon" PC game. This time, we learn about his time as Rollins on the pilot episode of "Star Trek: Voyager," who was supposed to have a more prominent role in the series. Scott was there with the original Captain Janeway, Geneviève Bujold, and explains what went wrong with her on set and how things immediately changed when Kate Mulgrew stepped in to take over. After that, we learn about his crazy audition story of he got the Goran'Agar role in the DS9 episode "Hippocratic Oath," working with Alexander Siddig and Colm Meaney while being directed by Rene Auberjonois covered in Jem'Hadar makeup and a wonderful tale about an act of kindness from the entire DS9 crew. Finally, it's all about the evil Xindi Commander Dolim from many episodes in season 3 of "Star Trek: Enterprise," including his makeup, working with Randy Oglesby, who Scott worked with previously in an award-winning play, having a fist fight with Scott Bakula in the season three finale, and how he ate the mouse! Enterprise fans – you know the scene! Plus, all about the modern horror Christmas classic "Jack Frost," his time on "Carnevale," a great tale about David Warner, and Scott takes a look at his Star Trek action figures! Visit fullempirepromotions.com to pick up signed items from Scott MacDonald from Star Trek and his other movies. Please subscribe to our brand new YouTube channel: www.youtube.com/@trekuntold . There you will see all the old episodes of this show, as well as new episodes and all of our other content, including shorts and some other fun things planned for the future. Visit my Amazon shop to check out tons of Trek products and other things I enjoy - https://www.amazon.com/shop/thefightnerd View the Teespring store for Trek Untold gear & apparel - https://my-store-9204078.creator-spring.com Support Trek Untold by becoming a Patreon at Patreon.com/TrekUntold. Don't forget to subscribe to the show and leave a rating if you like us! Follow Trek Untold on Social Media Instagram: http://www.instagram.com/trekuntoldTwitter: https://www.twitter.com/trekuntoldFacebook: https://www.facebook.com/trekuntold Follow Nerd News Today on Social Media Twitter: Twitter.com/NerdNews2DayInstagram: Instagram.com/NerdNewsTodayFacebook: Facebook.com/NerdNewsToday Trek Untold is sponsored by Treksphere.com, powered by the RAGE Works Podcast Network, and affiliated with Nerd News Today.

Howie welcomes Amy Carnevale of the Massachusetts State Committee. Carnevale announces on-air that she will be running for State Committee Chair against incumbent Jim Lyons. Seasoned listeners know Howie wants Lyons out, out, OUT! Then, tune in for this Monday's edition of "Let's Go, Brandon!" when callers air their inflation and shrinkflation grievances.

This week on Boner Cramps, we're celebrating the end of No Nut November the only way we know how, by bringing in our good friend Adam “The Cum Man” Carnevale to look at House Party for the PC, Sex Chess (Chess 2) for the PC and Porno Skyrim Mods for the PC. This is still safe to be played in schools. Email us at ThumbCrampsPod@gmail.com Find us on Twitter; Jackson | Duscher | Thumb Cramps | Adam Watch us on Twitch; Jackson | Duscher | Sanspants Radio | Adam You can now physically send us stuff to PO BOX 7127, Reservoir East, Victoria, 3073.Join our facebook group here or join our Discord here. Theme music by the wonderfully talented Benny Davis! You can find all his stuff at his website or check out his YouTube channel. Hosted on Acast. See acast.com/privacy for more information.

Our good friend and co-host Joel Duscher is out this week with the “virus that makes you dumb” which also retroactively explains last week's energy. Instead we're joined by our good friend Adam Carnevale who we definitely didn't just do a D&D episode exclusively for, we promise.  -- Make sure to check out all the other Wood Elf shows here -- Send us an email at baselessspeculation@gmail.com  You can physically send us stuff to PO BOX 7127, Reservoir East, Victoria, 3073. Follow us on Twitter:cJackson | Duscher | Zammit | Adam Learn more about your ad choices. Visit megaphone.fm/adchoices

On Episode 123: Lakes Management & Hurricane Prep, we speak to MJ Carnevale, Director of Public Works for the City of Winter Haven. MJ shares about lakes management, hurricane preparation and more.

Il mercoledì delle ceneri chiude il Carnevale e apre la Quaresima. Ma perché si chiama così? La quaresima è Il periodo dei 40 giorni prima della Pasqua, è caratterizzato da piccole astinenze, ad esempio: il divieto di mangiare carne il venerdì, serve ad arrivare al giorno della Pasqua - con l'anima totalmente purificata. Questo periodo inizia con il Mercoledì delle Ceneri, il giorno dopo il martedì grasso, ultimo giorno di carnevale. Durante questa giornata i cristiani vanno in chiesa per ricevere, sulla testa, un pizzico di cenere. Questa tradizione è diffusa quasi in tutta Italia, tranne a Milano. Per i milanesi dunque la Quaresima comincia direttamente la domenica successiva. Inoltre, sempre secondo la tradizione, le ceneri utilizzate per segnare le fronti dei fedeli sono ricavate bruciando i rami d'ulivo benedetti della Domenica delle Palme dell'anno precedente. Enroll in our online course for FREE and take the quiz --- Send in a voice message: https://anchor.fm/theitalianmind/message

Il Carnevale è una festa legata al mondo cattolico e cristiano, ma le sue origini sono pagane. Durante queste festività era lecito lasciarsi andare, liberarsi da obblighi e impegni, per dedicarsi allo scherzo e al gioco. Inoltre mascherarsi rendeva irriconoscibili il ricco e il povero, e scomparivano cosi le differenze sociali. Una volta terminate le feste, tutto tornava all normalità. La parola carnevale deriva dal latino carnem levare ovvero “eliminare la carne” poichè anticamente indicava il banchetto che si teneva l'ultimo giorno di carnevale (il martedì grasso) prima del periodo di digiuno della Quaresima durante la quale poi a nessuno era concesso di mangiare carne! Il Carnevale non ha una data fissa: ogni anno dipende da quando cade Pasqua. Il tempo di Carnevale infatti inizia la prima domenica delle nove che precedono quella di Pasqua e termina il martedi successivo, ovvero il martedì grasso, che precede il Mercoledi delle Ceneri, inizio della Quaresima. In Italia ogni regione festeggia il Carnevale a Venezia, si festeggia uno dei “Carnevali” più famosi del mondo; a Viareggio invece sono i carri allegorici a rendere tutto magico, cose come ad Acireale, in Sicilia; a Ivrea poi c'è la celebre Battaglia della Arance, mentre a Sciacca vengono realizzate splendide opere in cartapesta. Enroll for FREE in our online course and take the quiz --- Send in a voice message: https://anchor.fm/theitalianmind/message

Today I welcome Phoenix Carnevale. Phoenix is an actress, media personality, fitness trainer, martial arts and self-defense expert; she has been featured on MTV, CNN, and ESPN and in Shape, Self, and Latina magazines as a health and fitness expert. Phoenix is here to talk about women's self-defense, its relevance and importance regardless of age, and to share tips for women of all ages to keep them safe.

Sign up to our newsletter here. Join our facebook group here or join our Discord here.You can physically send us stuff to PO BOX 7127, Reservoir East, Victoria, 3073.Want to help support the show?Sanspants+ | Shop | TeesWant to get in contact with us?Email | Twitter | Website | Facebook | RedditOr individually at;Hayden | CassShut Up a Second is hosted and produced by Cass Paige and Hayden Bleechmore.Recorded and produced on Wurundjeri land, we respectfully acknowledge the Wurundjeri People of the Kulin Nation, pay our respect to their Elders past and present, and recognise that sovereignty was never ceded. Hosted on Acast. See acast.com/privacy for more information.

Mortgage broker and lender Geoff Carnevale used to be a one-man show. Now, he knows much better ways to do things. In this episode, Geoff talks about some misconceptions people have about entrepreneurial coaching and shares some of the incredible tips he's learned in The Strategic Coach® Program.

On Episode 114: Diving In to Natural Resources, we speak to Dustin Everitt with the City of Winter Haven & Shannon Carnevale with UF IFAS Extension Polk County. They share about all things natural resources, including taking a deep dive into our Chain of Lakes and even fun stories about opossum c-sections and more.