Podcasts about health's national institute

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Best podcasts about health's national institute

Latest podcast episodes about health's national institute

The United States of Anxiety
Kai Wright Presents Blindspot Episode 1: Mourning In America

The United States of Anxiety

Play Episode Listen Later Feb 2, 2024 35:54


Valerie Reyes-Jimenez called it “The Monster.” That's how some people described HIV and AIDS in the 1980s. Valerie thinks as many as 75 people from her block on New York City's Lower East Side died. They were succumbing to an illness that was not recognized as the same virus that was killing young, white, gay men just across town in the West Village. At the same time, in Washington, D.C., Gil Gerald, a Black LGBTQ+ activist, saw his own friends and colleagues begin to disappear, dying out of sight and largely ignored by the wider world. In the first episode of Blindspot: The Plague in the Shadows, host Kai Wright shares how HIV and AIDS was misunderstood from the start — and how this would shape the reactions of governments, the medical establishment and numerous communities for years to come. Listen to more episodes and subscribe to Blindspot here. Voices in this episode include: Valerie Reyes-Jimenez is an HIV-positive woman, activist, and organizer with Housing Works. She saw the AIDS crisis develop from a nameless monster into a pandemic from her home on New York City's Lower East Side. Dr. Larry Altman was one of the first full-fledged medical doctors to work as a daily newspaper reporter. He started at The New York Times in 1969. Dr. Anthony Fauci was director of the National Institutes of Health's National Institute of Allergy and Infectious Disease from 1984 to 2022. Known most recently for his work on Covid-19, Dr. Fauci was also a leading figure in the fight against HIV and AIDS. Gil Gerald is a Black HIV and AIDS activist and writer, who co-founded the National Coalition of Black Lesbians and Gays. Phill Wilson is the founder of the Black AIDS Institute, AIDS policy director for the city of Los Angeles at the height of the epidemic, and a celebrated AIDS activist in both the LGBTQ+ and Black communities since the early 1980s. Dr. Margaret Heagarty ran the pediatrics department of Harlem Hospital Center for 22 years. She died in December 2022. Blindspot is a co-production of The HISTORY® Channel and WNYC Studios, in collaboration with The Nation Magazine. A companion photography exhibit by Kia LaBeija featuring portraits from the series is on view through March 11 at The Greene Space at WNYC. Photography by Kia LaBeija is supported in part by the Economic Hardship Reporting Project. Tell us what you think. Email us at notes@wnyc.org. Send us a voice message by recording yourself on your phone and emailing us, or record one here. We're also on Instagram and X (Twitter) @noteswithkai.

Healthy Navajo K'é
Meet the Hosts of the Healthy Navajo K'é Podcast

Healthy Navajo K'é

Play Episode Listen Later Jan 31, 2024 48:11


Yá'át'ééh! Welcome to the heart of the Navajo Maternal and Child Health (MCH) Project! Join us on our podcast as we pull back the curtain to introduce the dynamic individuals- Amber-Rose Begay, DeeDee James, & Stacey Litson- driving the innovation and creativity that define our project. Get to know the personalities that bring passion, dedication, and a touch of humor to our collaborative efforts.  Expect entertaining and unexpected responses as we delve into fun questions that reveal our team members' unique quirks and stories. But it's not just about the laughs and anecdotes – we'll also discuss our project's current strides and achievements.  Our team is more than just individuals working together; we're a collective force with a shared vision, and we can't wait to share that journey with you.Looking forward, we'll offer a sneak peek into the exciting future efforts and initiatives that are brewing within our project. Hear about upcoming features, collaborations, and innovative ideas that keep us fueled with enthusiasm.Get ready to meet the faces, hear the stories, and witness the spirit that propels the Navajo MCH Project forward.Check out our social media pages! Facebook: @Navajo Maternal and Child Health Project at Diné College Instagram: @navajomchPlease email us if you have any questions, comments, or suggestions: navajomchproject@dinecollege.eduThis podcast was sponsored by the Arizona Department of Health Services through federal funding from the Health Resources & Services Administration, with support from the Navajo Native American Research Centers for Health (NARCH) Partnership between Diné College and Northern Arizona University through federal funding from the National Institute of Health's National Institute of General Medical Sciences, award number S06GM142121. The views expressed are the sole responsibility of the program staff and do not necessarily reflect the views of the Arizona Department of Health Services or the United States Government.

Blindspot: The Road to 9/11
Mourning in America

Blindspot: The Road to 9/11

Play Episode Listen Later Jan 18, 2024 35:08


Valerie Reyes-Jimenez called it “The Monster.” That's how some people described HIV and AIDS in the 1980s. Valerie thinks as many as 75 people from her block on New York City's Lower East Side died. They were succumbing to an illness that was not recognized as the same virus that was killing young, white, gay men just across town in the West Village.At the same time, in Washington, D.C., Gil Gerald, a Black LGBTQ+ activist, saw his own friends and colleagues begin to disappear, dying out of sight and largely ignored by the wider world.In our first episode of Blindspot: The Plague in the Shadows, we learn how HIV and AIDS was misunderstood from the start — and how this would shape the reactions of governments, the medical establishment and numerous communities for years to come.Voices in the episode include:• Valerie Reyes-Jimenez is an HIV-positive woman, activist, and organizer with Housing Works. She saw the AIDS crisis develop from a nameless monster into a pandemic from her home on New York City's Lower East Side.• Dr. Larry Altman was one of the first full-fledged medical doctors to work as a daily newspaper reporter. He started at The New York Times in 1969.• Dr. Anthony Fauci was director of the National Institutes of Health's National Institute of Allergy and Infectious Disease from 1984 to 2022. Known most recently for his work on Covid-19, Dr. Fauci was also a leading figure in the fight against HIV and AIDS.• Gil Gerald is a Black HIV and AIDS activist and writer, who co-founded the National Coalition of Black Lesbians and Gays.• Phill Wilson is the founder of the Black AIDS Institute, AIDS policy director for the city of Los Angeles at the height of the epidemic, and a celebrated AIDS activist in both the LGBTQ+ and Black communities since the early 1980s.• Dr. Margaret Heagarty ran the pediatrics department of Harlem Hospital Center for 22 years. She died in December 2022.Blindspot is a co-production of The HISTORY® Channel and WNYC Studios, in collaboration with The Nation Magazine.A companion photography exhibit by Kia LaBeija featuring portraits from the series is on view through March 11 at The Greene Space at WNYC. Photography by Kia LaBeija is supported in part by the Economic Hardship Reporting Project.

Healthy Navajo K'é
Pregnancy and Birth Stories Series Part 6c

Healthy Navajo K'é

Play Episode Listen Later Dec 20, 2023 37:02


Yá'át'ééh! Happy New Year's Eve! We are happy to announce the final part of the sixth release of our birthing series featuring our special guest, Karla Peaches. Ms. Peaches is a Diné woman, mother, doula, and peer lactation counselor. Her story is released in 3 parts: preconception, pregnancy, and postpartum. In this last episode, she will be sharing her postpartum journey after giving birth at home, reflecting on all the resources and people who supported her during her beautiful journey, and much more!We want to thank Karla for sharing her story and experiences. We hope you enjoy listening to part three, and don't forget to tune in parts one and two if you have not already.  Disclaimer: We'd like to let our audience know that these birthing stories include real people with real stories and may include topics on traumatic pregnancy and birthing experiences leading to loss of life, miscarriage, depression, suicide, and grief. If you are listening, please take breaks as needed. Check out our social media pages! Facebook: @Navajo Maternal and Child Health Project at Diné College Instagram: @navajomchPlease email us if you have any questions, comments, or suggestions: navajomchproject@dinecollege.eduThis podcast was sponsored by the Arizona Department of Health Services through federal funding from the Health Resources & Services Administration, with support from the Navajo Native American Research Centers for Health (NARCH) Partnership between Diné College and Northern Arizona University through federal funding from the National Institute of Health's National Institute of General Medical Sciences, award number S06GM142121. The views expressed are the sole responsibility of the program staff and do not necessarily reflect the views of the Arizona Department of Health Services or the United States Government.

Healthy Navajo K'é
Pregnancy and Birth Stories Series Part 6b

Healthy Navajo K'é

Play Episode Listen Later Nov 27, 2023 60:32


Yá'át'ééh! We are happy to announce part two of the sixth release of our birthing series featuring our special guest, Karla Peaches. Ms. Peaches is a Diné woman, mother, doula, and peer lactation counselor. Her story will be released in 3 parts: preconception, pregnancy, and postpartum. In this episode, she will be sharing her pregnancy journey, what steps she took to have a home birth and much more. You can listen to part two by scanning the QR code or visitingWe thank Karla for sharing her story and experiences. We hope you enjoy listening to part two, and don't forget to tune in for part 3 in the upcoming months. Disclaimer: We'd like to let our audience know that these birthing stories include real people with real stories and may include topics on traumatic pregnancy and birthing experiences leading to loss of life, miscarriage, depression, suicide, and grief. If you are listening, please take breaks as needed. Check out our social media pages! Facebook: @Navajo Maternal and Child Health Project at Diné College Instagram: @navajomchPlease email us if you have any questions, comments, or suggestions: navajomchproject@dinecollege.eduThis podcast was sponsored by the Arizona Department of Health Services through federal funding from the Health Resources & Services Administration, with support from the Navajo Native American Research Centers for Health (NARCH) Partnership between Diné College and Northern Arizona University through federal funding from the National Institute of Health's National Institute of General Medical Sciences, award number S06GM142121. The views expressed are the sole responsibility of the program staff and do not necessarily reflect the views of the Arizona Department of Health Services or the United States Government.

Healthy Navajo K'é
Pregnancy and Birth Stories Series Part 6a

Healthy Navajo K'é

Play Episode Listen Later Oct 23, 2023 50:12


Yá'át'ééh! We are happy to announce the sixth release of our birthing series featuring our special guest, Karla Peaches. Ms. Peaches is a Diné woman, mother, doula, and peer lactation counselor. She tells all about the challeges she faced with being diagnosed with PCOS and navigating the health system to get the best care,  the last days with her grandmother, and grief.  Her story will be released in 3 parts: preconception, pregnancy, and postpartum. We appreciate Karla for sharing her experiences with us. The purpose of this series is to provide a space for birthing familes to share thier experineces to help other birthing families become more informed about the ways pregnancy and birthing can happen. Disclaimer: We'd like to let our audience know that these birthing stories include real people with real stories and may include topics on traumatic pregnancy and birthing experiences leading to loss of life, miscarriage, depression, suicide, and grief. If you are listening, please take breaks as needed. Check out our social media pages! Facebook: @Navajo Maternal and Child Health Project at Diné College Instagram: @navajomchPlease email us if you have any questions, comments, or suggestions: navajomchproject@dinecollege.eduThis podcast was sponsored by the Arizona Department of Health Services through federal funding from the Health Resources & Services Administration, with support from the Navajo Native American Research Centers for Health (NARCH) Partnership between Diné College and Northern Arizona University through federal funding from the National Institute of Health's National Institute of General Medical Sciences, award number S06GM142121. The views expressed are the sole responsibility of the program staff and do not necessarily reflect the views of the Arizona Department of Health Services or the United States Government.

RARECast
Accelerating Gene Editing Therapies for Rare, Neurological Conditions

RARECast

Play Episode Listen Later Aug 3, 2023 32:18


In June, the National Institutes of Health's National Institute of Neurological Disorders and Stroke made a five-year, $22.8 million grant to a group led by The Jackson Laboratory to develop gene-editing therapies for four rare, neurological conditions. The use of a platform approach to develop therapies for multiple indications follows other efforts on going at the National Institutes of Health in the area of gene therapies. We spoke to Steve Murray, associate professor at The Jackson Laboratory, about the promise of gene-editing, the work being done under the grant, and why the work could have broad implications for treating rare genetic neurological conditions.

Healthy Navajo K'é
Pregnancy and Birthing Stories Series Part 5

Healthy Navajo K'é

Play Episode Listen Later Jul 20, 2023 50:50 Transcription Available


Yá'á'tééh! For the fifth installment of our birthing series, co-hosts DeeDee James and Lexa Ingram interview Sierra Sanchez, a young Coeur D'Alene woman, mother, doula, and peer lactation counselor will be sharing her pregnancy and birthing experiences in this episode. She tells all about her at-home birth, the challenges she faced, and funny moments that stood out to her. We appreciate Sierra for sharing her wonderful stories with us. The purpose of this series is to provide a space for birthing families to share their experiences to help other birthing families become informed about the ways pregnancy and birthing can happen.Disclaimer: We'd like to let our audience know that these birthing stories include real people with real stories and may include topics on traumatic pregnancy and birthing experiences leading to loss of life, miscarriage, depression, suicide, and grief. If you are listening, please take breaks as needed. If these topics are too much for you to handle, please join us again for our next episode and take care of yourself in the meantime.Check out our social media pages! Facebook: @Navajo Maternal and Child Health Project at Diné College Instagram: @navajomchPlease email us if you have any questions, comments, or suggestions: navajomchproject@dinecollege.eduThis podcast was sponsored by the Arizona Department of Health Services through federal funding from the Health Resources & Services Administration, with support from the Navajo Native American Research Centers for Health (NARCH) Partnership between Diné College and Northern Arizona University through federal funding from the National Institute of Health's National Institute of General Medical Sciences, award number S06GM142121. The views expressed are the sole responsibility of the program staff and do not necessarily reflect the views of the Arizona Department of Health Services or the United States Government.

The Oncology Nursing Podcast
Episode 268: Race in Research: From Subjects to Scientists, ONS Scholar-in-Residence Has a Career Commitment to Racial Equity

The Oncology Nursing Podcast

Play Episode Listen Later Jul 14, 2023 41:22


“If we're not driving our own research agenda and we're not asking the questions we see as important, we are not realizing the full potential of nursing. We know, because we are with patients, what the issues are for patients, for families, and for communities. We have to be able to say, ‘Nope, this is the question.'” Margaret (Peg) Rosenzweig, PhD, FNP-BC, AOCNP®, ONS's scholar-in-residence and professor at the University of Pittsburgh in Pennsylvania, told Jaime Weimer, MSN, RN, AGCNS-BS, AOCNS®, oncology clinical specialist at ONS, during a discussion about her oncology nursing clinical and research career, commitment to equity, and role as ONS's scholar-in-residence. You can earn free NCPD contact hours after listening to this episode and completing the evaluation linked below. Music Credit: “Fireflies and Stardust” by Kevin MacLeod Licensed under Creative Commons by Attribution 3.0 Earn 0.75 contact hours of nursing continuing professional development (NCPD) by listening to the full recording and completing an evaluation at myoutcomes.ons.org by July 14, 2025. The planners and faculty for this episode have no relevant financial relationships with ineligible companies to disclose. ONS is accredited as a provider of NCPD by the American Nurses Credentialing Center's Commission on Accreditation. Learning outcome: The learner will report an increase in knowledge related to race in research. Episode Notes Complete this evaluation for free NCPD.  Oncology Nursing Podcast Episode 107: Social Determinants Lead to Unequal Access to Health Care ONS clinical practice resources: Racial Disparities in Cancer Care: Biomarker Testing for Lung Cancer Racial Disparities in Cancer Care: First-Line Treatment Options and Side-Effect Management Racial Disparities in Cancer Care: Supportive and Hospice Care Racial Disparities in Cancer Care: Telehealth and Clinical Trial Options ONS Voice articles: Cancer Mortality Declines Among Black Patients but Remains Disproportionately High Diversity in Nursing Begins at the Student Level Diversity in Nursing: How the Profession Is Addressing Racial and Gender Gaps Specialized Risk Calculator May Reduce Disparities for Black Patients With Breast Cancer Racism, Health Inequities, and Unequal Access to Care Are Oncology Nursing Research Priorities ONS DEI Commitment Statement Implicit Bias in Nursing: Identifying and Confronting the Issue National Cancer Institute National Institutes of Health's National Institute on Minority Health and Health Disparities National Institute of Nursing Research To discuss the information in this episode with other oncology nurses, visit the ONS Communities.  To find resources for creating an ONS Podcast Club in your chapter or nursing community, visit the ONS Podcast Library.  To provide feedback or otherwise reach ONS about the podcast, email pubONSVoice@ons.org.  Highlights From Today's Episode “A commitment that we all have to have is toward more diversity in oncology nursing and in oncology research and thinking about what can I do in my world.” Timestamp (TS) 7:52 “Unless we listen to and really fully honor what the nurse can ask about their experience with patients, we're missing so much in the way that we can help patients' families and communities.” TS 17:08 “I think we haven't thought fully enough about the patient in the context of their life. I think we've thought about symptoms, but we have to think about the patient baring those symptoms, where they come from, and what they've experienced. So, I think incorporating the social determinants of health is very important.” TS 18:00 “White researchers will say, ‘It doesn't matter. You can hire White recruiters and as long as people are properly trained, that should not matter.' I feel like that is a bit of implicit bias that we as White researchers just don't recognize. We think it doesn't matter because it doesn't matter to us. But it does matter to Black women.” TS 30:13

Healthy Navajo K'é
Pregnancy and Birthing Stories Series Part 4

Healthy Navajo K'é

Play Episode Listen Later Jul 5, 2023 74:07


Yá'át'ééh! In today's episode, co-hosts DeeDee James and Lexa Ingram will talk to a special guest, Koltey Tso. Koltey is a Diné woman, mother, wife, and student. She will share her pregnancy journey battling infertility and polycystic ovary syndrome (PCOS) and talk about her birthing experience with her miracle baby. We appreciate Koltey's courage to share her sacred journey with us. This series aims to provide a safe space for birthing families to share their experiences to help other birthing families become informed about how pregnancy and birthing can happen. Disclaimer: We would like to let our audience know that these birthing stories include real people with real stories and may include topics on traumatic pregnancy and birthing experiences leading to loss of life, miscarriage, depression, suicide, and grief. If you are listening, please take breaks as needed. If these topics are too much for you to handle, please join us for our next episode and take care of yourself in the meantime.Check out our social media pages! Facebook: @Navajo Maternal and Child Health Project at Diné College Instagram: @navajomchPlease email us if you have any questions, comments, or suggestions: navajomchproject@dinecollege.eduThis podcast was sponsored by the Arizona Department of Health Services through federal funding from the Health Resources & Services Administration, with support from the Navajo Native American Research Centers for Health (NARCH) Partnership between Diné College and Northern Arizona University through federal funding from the National Institute of Health's National Institute of General Medical Sciences, award number S06GM142121. The views expressed are the sole responsibility of the program staff and do not necessarily reflect the views of the Arizona Department of Health Services or the United States Government.

Healthy Navajo K'é
Pregnancy and Birthing Stories Series Part 3

Healthy Navajo K'é

Play Episode Listen Later Jun 21, 2023 82:23 Transcription Available


Yá'á'tééh! For the third installment of our birthing series, co-hosts Amber-Rose Begay and Lexa Ingram interview Alyssa Peaches Armendez, a young Diné woman, mother, wife, and small business owner will be sharing her pregnancy with twins and birthing experiences in this episode.We appreciate Alyssa for sharing her beautiful stories with us. The purpose of this series is to provide a space for birthing families to share their experiences to help other birthing families become informed about the ways pregnancy and birthing can happen.Disclaimer: We'd like to let our audience know that these birthing stories include real people with real stories and may include topics on traumatic pregnancy and birthing experiences leading to loss of life, miscarriage, depression, suicide, and grief. If you are listening, please take breaks as needed. If these topics are too much for you to handle, please join us again for our next episode and take care of yourself in the meantime.Check out our social media pages! Facebook: @Navajo Maternal and Child Health Project at Diné College Instagram: @navajomchPlease email us if you have any questions, comments, or suggestions: navajomchproject@dinecollege.eduThis podcast was sponsored by the Arizona Department of Health Services through federal funding from the Health Resources & Services Administration, with support from the Navajo Native American Research Centers for Health (NARCH) Partnership between Diné College and Northern Arizona University through federal funding from the National Institute of Health's National Institute of General Medical Sciences, award number S06GM142121. The views expressed are the sole responsibility of the program staff and do not necessarily reflect the views of the Arizona Department of Health Services or the United States Government.

Healthy Navajo K'é
Navajo Birth Cohort Study

Healthy Navajo K'é

Play Episode Listen Later May 23, 2023 76:25


Yá'át'ééh. Join cohosts DeeDee James and Stacey Litson in a discussion with Navajo Birth Cohort Study's (NBCS) field staff, Maria Welch, to better understand the relationship between uranium exposures and birth outcomes and early developmental delays. The Navajo Birth Cohort Study's responsibility to the Navajo People is to conduct research while remembering that childbirth is one of the most sacred events for Navajo families. We appreciate your continued support!Check out the NBCS website linked on our social media pages.  Check out our social media pages! Facebook: @Navajo Maternal and Child Health Project at Diné College Instagram: @navajomchPlease email us if you have any questions, comments, or suggestions: navajomchproject@dinecollege.eduThis podcast was sponsored by the Arizona Department of Health Services through federal funding from the Health Resources & Services Administration, with support from the Navajo Native American Research Centers for Health (NARCH) Partnership between Diné College and Northern Arizona University through federal funding from the National Institute of Health's National Institute of General Medical Sciences, award number S06GM142121. The views expressed are the sole responsibility of the program staff and do not necessarily reflect the views of the Arizona Department of Health Services or the United States Government.

Healthy Navajo K'é
Eating on a Budget

Healthy Navajo K'é

Play Episode Listen Later Apr 13, 2023 41:37 Transcription Available


Join co-hosts Amber-Rose and Lexa Ingram in a discussion with Northern Arizona University Nutrition and Food majors Ramsi Geiser and Samantha Soulsby about the nutrition and health journey and trying to find what works for you. They will be sharing 8 budget grocery shopping tips, budget-friendly meal planning, sharing recipes, and snack ideas including tips for diabetics and prediabetics, how to read a nutrition label, and more. We appreciate your continued support!Check out our social media pages! Facebook: @Navajo Maternal and Child Health Project at Diné College Instagram: @navajomchPlease email us if you have any questions, comments, or suggestions: navajomchproject@dinecollege.eduThis podcast was sponsored by the Arizona Department of Health Services through federal funding from the Health Resources & Services Administration, with support from the Navajo Native American Research Centers for Health (NARCH) Partnership between Diné College and Northern Arizona University through federal funding from the National Institute of Health's National Institute of General Medical Sciences, award number S06GM142121. The views expressed are the sole responsibility of the program staff and do not necessarily reflect the views of the Arizona Department of Health Services or the United States Government.

Healthy Navajo K'é
Pregnancy and Birthing Stories Series Part 2

Healthy Navajo K'é

Play Episode Listen Later Feb 17, 2023 52:39 Transcription Available


Yá'áh'tééh! For the second installment of our birthing series, co-hosts Amber-Rose Begay and Lexa Ingram will be interviewing Kiara Tom, a young Diné woman and mother, will be sharing her pregnancy and birthing experiences on this episode. We appreciate Kiara for sharing her beautiful stories with us. The purpose of this series is to provide a space for birthing families to share their experiences to help other birthing families become informed about the ways pregnancy and birthing can happen.Disclaimer: We'd like to let our audience know that these birthing stories include real people with real stories and may include topics on traumatic pregnancy and birthing experiences leading to loss of life, miscarriage, depression, suicide, and grief. If you are listening, please take breaks as needed. If these topics are too much for you to handle, please join us again for our next episode and take care of yourself in the meantime.Check out our social media pages! Facebook: @Navajo Maternal and Child Health Project at Diné College Instagram: @navajomchPlease email us if you have any questions, comments, or suggestions: navajomchproject@dinecollege.eduThis podcast was sponsored by the Arizona Department of Health Services through federal funding from the Health Resources & Services Administration, with support from the Navajo Native American Research Centers for Health (NARCH) Partnership between Diné College and Northern Arizona University through federal funding from the National Institute of Health's National Institute of General Medical Sciences, award number S06GM142121. The views expressed are the sole responsibility of the program staff and do not necessarily reflect the views of the Arizona Department of Health Services or the United States Government.

Aging-US
Transcriptomic Analysis of Human ALS Skeletal Muscle Reveals…

Aging-US

Play Episode Listen Later Jan 12, 2023 3:33


A new research paper was published in Aging (Aging-US) Volume 14, Issue 24, entitled, “Transcriptomic analysis of human ALS skeletal muscle reveals a disease-specific pattern of dysregulated circRNAs.” Circular RNAs are abundant, covalently closed transcripts that arise in cells through back-splicing and display distinct expression patterns across cells and developmental stages. While their functions are largely unknown, their intrinsic stability has made them valuable biomarkers in many diseases. In this new study, researchers Dimitrios Tsitsipatis, Krystyna Mazan-Mamczarz, Ying Si, Allison B. Herman, Jen-Hao Yang, Abhishek Guha, Yulan Piao, Jinshui Fan, Jennifer L. Martindale, Rachel Munk, Xiaoling Yang, Supriyo De, Brijesh K. Singh, Ritchie Ho, Myriam Gorospez, and Peter H. King from the National Institutes of Health's National Institute on Aging, The University of Alabama at Birmingham, Birmingham Veterans Affairs Medical Center, and Cedars-Sinai Medical Center set out to examine circRNA patterns in amyotrophic lateral sclerosis (ALS). By RNA-sequencing analysis, the researchers first identified circRNAs and linear RNAs that were differentially abundant in skeletal muscle biopsies from ALS compared to normal individuals. “By RT-qPCR analysis, we confirmed that 8 circRNAs were significantly elevated and 10 were significantly reduced in ALS, while the linear mRNA counterparts, arising from shared precursor RNAs, generally did not change.” Several of these circRNAs were also differentially abundant in motor neurons derived from human induced pluripotent stem cells (iPSCs) bearing ALS mutations, and across different disease stages in skeletal muscle from a mouse model of ALS (SOD1G93A). Interestingly, a subset of the circRNAs significantly elevated in ALS muscle biopsies were significantly reduced in the spinal cord samples from ALS patients and ALS (SOD1G93A) mice. In sum, the researchers identified differentially abundant circRNAs in ALS-relevant tissues (muscle and spinal cord) that could inform about neuromuscular molecular programs in ALS and guide the development of therapies. “As our studies advance, we will investigate the function of the most promising and abundant circRNAs, among the 18 circRNAs reported here. We are especially interested in those that appeared to be specific for ALS (Figure 2), as they may help to characterize disease-associated molecular pathways that could be targeted therapeutically.” DOI: https://doi.org/10.18632/aging.204450 Corresponding Authors: Myriam Gorospe - GorospeM@grc.nia.nih.gov, Dimitrios Tsitsipatis - dimitrios.tsitsipatis@nih.gov, Peter H. King - phking@uabmc.edu Keywords: amyotrophic lateral sclerosis, circular RNAs, neurodegenerative disease, human skeletal muscle, human spinal cord tissue About Aging-US: Launched in 2009, Aging (Aging-US) publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at www.Aging-US.com​​ and connect with us: SoundCloud – https://soundcloud.com/Aging-Us Facebook – https://www.facebook.com/AgingUS/ Twitter – https://twitter.com/AgingJrnl Instagram – https://www.instagram.com/agingjrnl/ YouTube – https://www.youtube.com/agingus​ LinkedIn – https://www.linkedin.com/company/aging/ Reddit – https://www.reddit.com/user/AgingUS Pinterest – https://www.pinterest.com/AgingUS/ For media inquiries, please contact media@impactjournals.com.

Healthy Navajo K'é
Pregnancy and Birthing Stories Series Part 1

Healthy Navajo K'é

Play Episode Listen Later Dec 22, 2022 41:31


Yá'áh'tééh! To kick off our series, Chantal Dominguez, a Diné wife and mother, will be sharing her pregnancy and birthing experiences on this episode. We appreciate Chantal for sharing her beautiful stories with us. The purpose of this series is to provide a space for birthing families to share their experiences to help other birthing families become informed about the ways pregnancy and birthing can happen.   Disclaimer: We'd like to let our audience know that these birthing stories include real people with real stories and may include topics on traumatic pregnancy and birthing experiences leading to loss of life, miscarriage, depression, suicide, and grief. If you are listening, please take breaks as needed. If these topics are too much for you to handle, please join us again for our next episode and take care of yourself in the meantime. Facebook: @Navajo Maternal and Child Health Project at Diné CollegeInstagram: @navajomch Please email us if you have any questions, comments or suggestions: navajomchproject@dinecollege.edu This podcast was sponsored by the Arizona Department of Health Services through federal funding from the Health Resources & Services Administration, with support from the Navajo Native American Research Centers for Health (NARCH) Partnership between Diné College and Northern Arizona University through federal funding from the National Institute of Health's National Institute of General Medical Sciences, award number S06GM142121. The views expressed are the sole responsibility of the program staff, and do not necessarily reflect the views of the Arizona Department of Health Services or the United States Government.

Healthy Navajo K'é
Interview with Indian Health Services Health Professional on COVID-19 Vaccinations for Children

Healthy Navajo K'é

Play Episode Listen Later Dec 13, 2022 24:09


Guest hosts Shawndeena George and Tressica Johnson with the Navajo NARCH Project at Diné College, interview Dr. Diana Hu, a Pediatrician at Tuba City Regional Health Care Corporation and the vaccine coordinator for Navajo Area Indian Health Services. Dr. Hu discusses the importance and benefits of covid vaccinations for children, covid vaccine side affects and risks, and how to discuss vaccines with children. If you have questions about covid or covid vaccines, please call the TCRHCC hotline 928-606-4647 or 928-707-4865. Please email us if you have any questions, comments or suggestions: navajomchproject@dinecollege.eduThis podcast was sponsored by the Arizona Department of Health Services through federal funding from the Health Resources & Services Administration, with support from the Navajo Native American Research Centers for Health (NARCH) Partnership between Diné College and Northern Arizona University through federal funding from the National Institute of Health's National Institute of General Medical Sciences, award number S06 GMS-142121. The views expressed are the sole responsibility of the program staff, and do not necessarily reflect the views of the Arizona Department of Health Services or the United States Government.

EntheoRadio
DMT Dr Rick Strassman and The Psychedelic Handbook P2

EntheoRadio

Play Episode Listen Later Aug 29, 2022 48:29


Hugh T Alkemi, host of EntheoRadio, is honored for a second time with Psychedelic Research Renaissance Founding Father Rick Strassman, MD who has been on The Joe Rogan Experience just this month and on Entheoradio about two years ago. It's always a fun time discussing the impact of psychedelics from both a research and a cultural standpoint with Dr Rick. This part 2 of 2 of the interview becomes particularly intense and includes both powerful wisdom and cautionary speculation about the future of Psychedelics in the USA.Bio for Rick Strassman, MD:Rick Strassman was born in Los Angeles, California in 1952. He attended public schools in southern California's San Fernando Valley and graduated from Ulysses S. Grant High School in Van Nuys in 1969. As an undergraduate, he majored in zoology at Pomona College in Claremont California for two years before transferring to Stanford University, where he graduated with departmental honors in biological sciences in 1973. During summers in college, he worked for RedKen Laboratories, developing cosmetics and a line of hair dyes. In addition, he performed laboratory research at Stanford, on the development of the chicken embryo's nervous system. He attended the Albert Einstein College of Medicine of Yeshiva University in the Bronx, New York, where he obtained his medical degree with honors in 1977.Dr. Strassman took his internship and general psychiatry residency at the University of California, Davis, Medical Center in Sacramento, and received the Sandoz Award for outstanding graduating resident in 1981. After graduating, he worked for a year in Fairbanks, Alaska in community mental health and private psychiatric practice. From 1982-1983, he obtained fellowship training in clinical psychopharmacology research at the University of California, San Diego's Veteran's Administration Medical Center. He then served on the clinical faculty in the department of psychiatry at UC Davis Medical Center, before taking a full-time academic position in the department of psychiatry at the University of New Mexico School of Medicine in Albuquerque in 1984.At UNM, Dr. Strassman performed clinical research investigating the function of the pineal hormone melatonin in which his research group documented the first known role of melatonin in humans. He also began the first new US government approved clinical research with psychedelic drugs in over twenty years, focusing on DMT and to a lesser extent, psilocybin. He received grant support from the National Institutes of Health's National Institute on Drug Abuse, as well as from the Scottish Rite Foundation for Schizophrenia Research. Before leaving the University in 1995, he attained the rank of tenured Associate Professor of Psychiatry and was awarded the UNM General Clinical Research Center's Research Scientist Award.In 1984, he received lay ordination in a Western Buddhist order, and co-founded, and for several years administered, a lay Buddhist meditation group associated with the same order. Dr. Strassman underwent a four-year personal psychoanalysis in New Mexico between 1986 and 1990.From 1996 to 2000, while living in the Pacific Northwest of the United States, Dr. Strassman worked in community mental health centers in Washington State in Bellingham and Port Townsend. For the next four years, he had a solo private practice in Taos, New Mexico. After two years working near the Navajo Nation in Gallup NM, he returned to northern New Mexico in 2006, where he provided psychiatric services at a mental health center in Espanola. Since mid-2008, he has been writing full-time.Dr. Strassman's “DMT: The Spirit Molecule,” an account of his DMT and psilocybin studies, has sold a quarter-million copies as of mid-2021, and been translated into over a dozen languages, including Mandarin. He co-produced an independent documentary by the same name, which was the most-streamed independent drug documentary on Netflix. He also is the author of “DMT and the Soul of Prophecy,” “Joseph Levy Escapes Death,” and a co-author of “Inner Paths to Outer Space.”He has published over 40 peer-reviewed scientific papers and has served as a reviewer for 20 psychiatric research journals. He has been a consultant to the US Food and Drug Administration, National Institute on Drug Abuse, Veteran's Administration Hospitals, Social Security Administration, and other state and local agencies. He has provided consultation to many of the psychedelic startups that began appearing in 2020, including Atai, MindMed, and The Noetic Fund. He is on the Scientific Advisory Boards for Alexander Shulgin Research Institute and Ninnion Therapeutics.He currently is Clinical Associate Professor of Psychiatry at the University of New Mexico School of Medicine and lives in Gallup, New Mexico.ENTHEORADIO IS SPONSORED BY:Mushroom Shaman Brand Supplements and ServicesHttps://linktr.ee/mushroomshaman/Alkemi Ormus Products and ExtractsAlkemi.gold Buy his book through his site to get a personal inscription: https://www.rickstrassman.com/publications/the-psychedelic-handbook/The Psychedelic Handbook:Entering the world of psychedelic drugs can be challenging, and many aren't sure where to start. As research continues to expand and legalization looms on the horizon for psychedelics like psilocybin, you may need a guide to navigate what psychedelics are, how they work, and their potential benefits and risks.The Psychedelic Handbook is a complete manual that is accessible to anyone with an interest in these “mind-manifesting” substances. Packed with information on psilocybin, LSD, DMT/ayahuasca, mescaline/peyote, ketamine, MDMA, ibogaine, 5-methoxy-DMT (“the toad”), and Salvia divinorum/salvinorin A, this book is your ultimate reference for understanding the science and history of psychedelics; discovering their potential to treat depression, PTSD, substance abuse, and other disorders, as well as to increase wellness, creativity, and meditation; learning how to safely trip and explaining what we know about microdosing; and recognizing and caring for negative reactions to psychedelics.Clinical research psychiatrist, father of the American psychedelic research renaissance, and best-selling author of DMT: The Spirit Molecule, Dr. Rick Strassman shares his experience and perspectives as neither advocate nor foe of psychedelics in order to help readers understand the effects of these remarkable drugs.

EntheoRadio
DMT-Dr Rick Strassman and the Psychedelic Handbook P1

EntheoRadio

Play Episode Listen Later Aug 29, 2022 39:00


Hugh T Alkemi, host of EntheoRadio, is honored for a second time with Psychedelic Research Renaissance Founding Father Rick Strassman, MD who has been on The Joe Rogan Experience just this month and on Entheoradio about two years ago. It's always a fun time discussing the impact of psychedelics from both a research and a cultural standpoint with Dr Rick. This show includes suggestions and speculations about consciousness and the ongoing hype filled, psychedelic trend in the United States and gets especially intense in the part two of this episode. This is part 1 of 2.Bio for Rick Strassman, MD:Rick Strassman was born in Los Angeles, California in 1952. He attended public schools in southern California's San Fernando Valley and graduated from Ulysses S. Grant High School in Van Nuys in 1969. As an undergraduate, he majored in zoology at Pomona College in Claremont California for two years before transferring to Stanford University, where he graduated with departmental honors in biological sciences in 1973. During summers in college, he worked for RedKen Laboratories, developing cosmetics and a line of hair dyes. In addition, he performed laboratory research at Stanford, on the development of the chicken embryo's nervous system. He attended the Albert Einstein College of Medicine of Yeshiva University in the Bronx, New York, where he obtained his medical degree with honors in 1977.Dr. Strassman took his internship and general psychiatry residency at the University of California, Davis, Medical Center in Sacramento, and received the Sandoz Award for outstanding graduating resident in 1981. After graduating, he worked for a year in Fairbanks, Alaska in community mental health and private psychiatric practice. From 1982-1983, he obtained fellowship training in clinical psychopharmacology research at the University of California, San Diego's Veteran's Administration Medical Center. He then served on the clinical faculty in the department of psychiatry at UC Davis Medical Center, before taking a full-time academic position in the department of psychiatry at the University of New Mexico School of Medicine in Albuquerque in 1984.At UNM, Dr. Strassman performed clinical research investigating the function of the pineal hormone melatonin in which his research group documented the first known role of melatonin in humans. He also began the first new US government approved clinical research with psychedelic drugs in over twenty years, focusing on DMT and to a lesser extent, psilocybin. He received grant support from the National Institutes of Health's National Institute on Drug Abuse, as well as from the Scottish Rite Foundation for Schizophrenia Research. Before leaving the University in 1995, he attained the rank of tenured Associate Professor of Psychiatry and was awarded the UNM General Clinical Research Center's Research Scientist Award.In 1984, he received lay ordination in a Western Buddhist order, and co-founded, and for several years administered, a lay Buddhist meditation group associated with the same order. Dr. Strassman underwent a four-year personal psychoanalysis in New Mexico between 1986 and 1990.From 1996 to 2000, while living in the Pacific Northwest of the United States, Dr. Strassman worked in community mental health centers in Washington State in Bellingham and Port Townsend. For the next four years, he had a solo private practice in Taos, New Mexico. After two years working near the Navajo Nation in Gallup NM, he returned to northern New Mexico in 2006, where he provided psychiatric services at a mental health center in Espanola. Since mid-2008, he has been writing full-time.Dr. Strassman's “DMT: The Spirit Molecule,” an account of his DMT and psilocybin studies, has sold a quarter-million copies as of mid-2021, and been translated into over a dozen languages, including Mandarin. He co-produced an independent documentary by the same name, which was the most-streamed independent drug documentary on Netflix. He also is the author of “DMT and the Soul of Prophecy,” “Joseph Levy Escapes Death,” and a co-author of “Inner Paths to Outer Space.”He has published over 40 peer-reviewed scientific papers and has served as a reviewer for 20 psychiatric research journals. He has been a consultant to the US Food and Drug Administration, National Institute on Drug Abuse, Veteran's Administration Hospitals, Social Security Administration, and other state and local agencies. He has provided consultation to many of the psychedelic startups that began appearing in 2020, including Atai, MindMed, and The Noetic Fund. He is on the Scientific Advisory Boards for Alexander Shulgin Research Institute and Ninnion Therapeutics.He currently is Clinical Associate Professor of Psychiatry at the University of New Mexico School of Medicine and lives in Gallup, New Mexico.ENTHEORADIO IS SPONSORED BY:Mushroom Shaman Brand Supplements and ServicesHttps://linktr.ee/mushroomshaman/Alkemi Ormus Products and ExtractsAlkemi.gold Buy his book through his site to get a personal inscription: https://www.rickstrassman.com/publications/the-psychedelic-handbook/The Psychedelic Handbook:Entering the world of psychedelic drugs can be challenging, and many aren't sure where to start. As research continues to expand and legalization looms on the horizon for psychedelics like psilocybin, you may need a guide to navigate what psychedelics are, how they work, and their potential benefits and risks.The Psychedelic Handbook is a complete manual that is accessible to anyone with an interest in these “mind-manifesting” substances. Packed with information on psilocybin, LSD, DMT/ayahuasca, mescaline/peyote, ketamine, MDMA, ibogaine, 5-methoxy-DMT (“the toad”), and Salvia divinorum/salvinorin A, this book is your ultimate reference for understanding the science and history of psychedelics; discovering their potential to treat depression, PTSD, substance abuse, and other disorders, as well as to increase wellness, creativity, and meditation; learning how to safely trip and explaining what we know about microdosing; and recognizing and caring for negative reactions to psychedelics.Clinical research psychiatrist, father of the American psychedelic research renaissance, and best-selling author of DMT: The Spirit Molecule, Dr. Rick Strassman shares his experience and perspectives as neither advocate nor foe of psychedelics in order to help readers understand the effects of these remarkable drugs.

The Gary Null Show
The Gary Null Show - 05.09.22

The Gary Null Show

Play Episode Listen Later May 9, 2022 59:08


Lower risk of dementia found among people with higher carotenoid levels National Institutes of Health's National Institute on Aging, May 6 2022.  An article appearing on in Neurology® reported an association between higher levels of several carotenoids and a lower risk of developing Alzheimer disease and other dementias during a 16 to 17-year average period. Carotenoids are a family of yellow to red plant pigments, including beta-carotene, which have an antioxidant effect.  Participants whose levels of the carotenoids lutein, zeaxanthin and beta-cryptoxanthin were highest were likelier to develop dementia later in life than individuals with lower levels. Among those aged 65 and older upon enrollment, each approximate 15.4 micromole per liter increase in lutein and zeaxanthin was associated with a 7% decrease in dementia risk during follow-up. For beta-cryptoxanthin, each 8.6 micromole per liter increase was associated with a 14% reduction among those older than 45 at the beginning of the study.  “Further studies are needed to test whether adding these antioxidants can help protect the brain from dementia,” Dr Beydoun concluded.     A Mediterranean-style diet decreases the levels of the inflammatory marker called C-reactive protein University of Bologna (Italy), May 3, 2022    Sticking to a Mediterranean style diet decreases the levels of the inflammatory marker called C-reative protein, linked to ageing, finds the EU funded project NU-AGE.  Another positive effect of this diet was that the rate of bone loss in people with osteoporosis was reduced. Other parameters such as insulin sensitivity, cardiovascular health, digestive health and quality of life are yet to be analysed.   This is the first project that goes in such depths into the effects of the Mediterranean diet on health of elderly population. We are using the most powerful and advanced techniques including metabolomics, transcriptomics, genomics and the analysis of the gut microbiota to understand what effect, the Mediterranean style diet has on the population of over 65 years old" said prof. Claudio Franceschi, project coordinator from the University of Bologna, Italy.   The project was conducted in five European countries: France, Italy, the Netherlands, Poland and the UK and involved 1142 participants. There are differences between men and women as well as among participants coming from the different countries. Volunteers from five countries differed in genetics, body composition, compliance to the study, response to diet, blood measurements, cytomegalovirus positivity and inflammatory parameters.       Resveratrol's blood pressure benefits may pass from mother to child University of Alberta and University of Adelaide, May 4, 2022   Hereditary hypertension may not pass the generations if the mother is given resveratrol supplements during pregnancy, suggests a new study with lab rats. Offspring of spontaneously hypertensive rats were found to be protected from elevated blood pressure once they reached adulthood if their mothers had received resveratrol supplementation during pregnancy.   “Maternal perinatal resveratrol supplementation prevented the onset of hypertension in adult offspring  and nitric oxide synthase inhibition normalized these blood pressure differences, suggesting improved nitric oxide bioavailability underlies the hemodynamic alterations,” wrote the researchers in the journal Hypertension .   The new study supplemented the diets of spontaneously hypertensive female rats with 0 or 4 g/kg diet of resveratrol from gestational day 0.5 until postnatal day 21. The offspring of these rats were then followed to adulthood.   Results showed that the adult offspring had significantly lower blood pressure than their mothers. Additional tests indicated that the potential blood pressure lowering activity observed in the resveratrol-fed animals was not linked to nitric oxide       Krill oil may be beneficial to muscle function and size in healthy people over the age of 65 University of Glasgow (Scotland), May 6, 2022   The study—led by the University of Glasgow's Institute of Cardiovascular and Medical Sciences (ICAMS) and published in Clinical Nutrition—found that krill oil supplementation of four grams per day could have beneficial effects on skeletal muscle function and size in this age group. The research found that healthy adult participants who had received daily krill oil supplementation for six months showed statistically and clinically significant increases in muscle function and size. Krill oil contains high concentrations of the omega-3 fatty acids DHA and EPA, which previous scientific studies have shown are important nutrients for the body as it ages. The randomized, double blind, controlled trial included 102 men and women all above 65 years of age. The participants were relatively inactive to engaging in less than one hour of self-reported exercise each week on entry to the study. The study found that participants receiving daily krill oil supplements showed the following improvements (from baseline) at the end of the study: Increase in thigh muscle strength (9.3%), grip strength (10.9%) and thigh muscle thickness (3.5%), relative to control group. Increase in red blood cell fatty acid profile for EPA 214%, DHA 36% and the omega-3 index 61%, relative to control group. Increased M-Wave of 17% (relative to the control group), which shows the excitability of muscle membranes.       New research shows cannabis flower is effective for treating fatigue University of New Mexico, May 6, 2022 Researchers at The University of New Mexico have used a mobile software app to measure the effects of consuming different types of common and commercially available cannabis flower products on fatigue levels in real-time. As part of the study, researchers showed that over 91 percent of people in the study sample that used cannabis flower to treat fatigue reported symptom improvement.  In their recent study, titled "The Effects of Consuming Cannabis Flower for Treatment of Fatigue," published in the journal Medical Cannabis and Cannabinoids, the UNM researchers showed that using cannabis results in immediate improvement for feelings of fatigue in the majority of users. This was the first large-scale study to show that on average, people are likely to experience a 3.5 point improvement of feelings of fatigue on a 0-10 scale after combusting cannabis flower products The study was based on data from 3,922 cannabis self-administration sessions recorded by 1,224 people.  "One of the most surprising outcomes of this study is that cannabis, in general, yielded improvements in symptoms of fatigue, rather than just a subset of products, such as those with higher THC or CBD levels or products characterized as sativa rather than indica," said co-author and Associate Professor Sarah Stith. "We're excited to see real-world data and studies support the use of cannabinoids for helping individuals manage their fatigue and energy levels," says Tyler Dautrich. "This obviously has implications for patients experiencing fatigue as a symptom of their medical condition, but we also feel this can lead to healthier options to the current energy drink and supplement market."   Study: Coconut oil contains molecules found to be effective against coronavirus Ateneo de Manila University (Philippines), May 2, 2022 New research out of the Philippines has uncovered yet another potentially viable candidate for treating and preventing the Wuhan coronavirus (COVID-19) without the need for pharmaceuticals or vaccines, and it is lovingly known to many of our readers as coconut oil. Dr. Fabian M. Dayrit, PhD, from Ateneo de Manila University, along with the help of Dr. Mary T. Newport, MD, from Spring Hill Neonatology in Florida, looked at the known antiviral benefits of coconut oil to see if they may also apply to the Wuhan coronavirus (COVID-19). Lauric acid (C12), along with its derivative monolaurin, has been known for many years to possess natural antiviral activity. A medium-chain fatty acid that comprises about 50 percent of coconut oil's makeup, lauric acid is widely recognized as a “super” nutrient, as is monolaurin, which is produced by the body's own enzymes upon ingestion of coconut oil. These nutrients work in tandem to disintegrate the “envelopes” that surround viruses, and this includes the Wuhan coronavirus (COVID-19). These two nutrients can also inhibit late-stage maturation in the replicative cycle of viruses, as well as prevent the binding of viral proteins to the host cell membrane. Another antiviral compound found in coconut oil that also plays a protective role is capric acid (C10), along with its derivative monocaprin. Though it only makes up about seven percent of coconut oil, capric acid has shown effectiveness against HIV-1, which is important because evidence has emerged to suggest that the Wuhan coronavirus (COVID-19) may contain HIV DNA. Videos: 1. Brazil's Lula proposes creating Latin American currency to ‘be freed of US dollar' dependency (part 1)   2. Bonhoeffer‘s Theory of Stupidity (5:58)   3.  2022.05.08 Ihor Kolomoisky Is In Trouble (6:52)

Aging-US
Paper Spotlight: Protein Linked to Aging-Related Muscle Loss

Aging-US

Play Episode Listen Later Apr 14, 2022 7:00


Listen to a blog summary of this priority research paper published in Volume 13, Issue 11, entitled, "GRSF1 deficiency in skeletal muscle reduces endurance in aged mice." ________________________________ Skeletal muscle is responsible for regulating physical movement and comprises between 30 and 40% of the human body's mass. The loss of skeletal muscle has major impacts on overall health and quality of life—leading to frailty and a decreased ability to perform activities of daily living. The most common cause of muscle loss is aging, and a prevalent pattern of aging-associated muscular decline is known as sarcopenia. “With advancing age, the progressive loss of skeletal muscle mass and function, known as sarcopenia, leads to reduced muscle strength and diminishes individual mobility, quality of life, and lifespan [12].” In a research paper published in Aging (Aging-US) Volume 13, Issue 11, researchers from National Institutes of Health's National Institute on Aging and Chungnam National University investigated a protein that may play a role in aging-related muscle loss. Their paper was published on June 2, 2021, and entitled, “GRSF1 deficiency in skeletal muscle reduces endurance in aged mice.” Full blog - https://aging-us.org/2022/04/protein-linked-to-aging-related-muscle-loss/ DOI - https://doi.org/10.18632/aging.203151 Corresponding authors - Chang-Yi Cui - cuic@grc.nia.nih.gov, and Myriam Gorospe - myriam-gorospe@nih.gov Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.203151 Keywords - aging, skeletal muscle aging, GRSF1, RNA-binding protein, mouse aging About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at http://www.Aging-US.com​​ and connect with us: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ Twitter - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/agingus​ LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Aging-US is published by Impact Journals, LLC: http://www.ImpactJournals.com​​ Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM

Aging-US
Trending With Impact: Worms Reveal Early Event in Neurodegeneration

Aging-US

Play Episode Listen Later Nov 19, 2021 5:12


Many aging-associated neurodegenerative disorders, including Alzheimer's disease, involve the aggregation of abnormal tau in nerve cells (neurons). Normally, tau proteins function to stabilize microtubules in the brain. Tauopathy occurs when tau proteins become misfolded and misshapen (which turns tau into toxic tau). They then continue to proliferate and bind to each other, forming tau oligomers. These tau oligomers are more toxic and have a greater potential to spread tau pathology. Before toxic tau snowballs into neurodegenerative disorders, the events that lead up to abnormal tau have remained elusive to researchers. “While the association between tau levels and energy metabolism is established, it is not clear whether mitochondrial dysfunction is an early pathological feature of high levels of tau or a consequence of its excessive formation of protein aggregates.” Previous studies have demonstrated an association between tau levels and mitochondrial metabolism, however, determining which one proceeds the other has yet to be fully illuminated. Shedding light on this subject, researchers—from the University of Copenhagen, National and Kapodistrian University of Athens and the National Institutes of Health's National Institute on Aging—used a Caenorhabditis elegans (C. elegans; roundworm/nematode) model of tau to examine mitochondrial changes over time. Their paper was chosen as the cover of Aging (Aging-US) Volume 13, Issue 21, published in November of 2021 and entitled, “Alteration of mitochondrial homeostasis is an early event in a C. elegans model of human tauopathy”. Full blog - https://www.impactjournals.com/journals/blog/aging/trending-with-impact-worms-reveal-early-event-in-neurodegeneration/ Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.203683 DOI - https://doi.org/10.18632/aging.203683 Full Text - https://www.aging-us.com/article/203683/text Correspondence to: Konstantinos Palikaras email: palikarask@med.uoa.gr, Mansour Akbari email: akbari@sund.ku.dk and Vilhelm A. Bohr email: bohrv@grc.nia.nih.gov Keywords: aging, Alzheimer's disease, C. elegans, energy metabolism, mitochondria, tau, tauopathy About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at http://www.Aging-US.com​​ or connect with us on: SoundCloud - https://soundcloud.com/aging-us​ Facebook - https://www.facebook.com/AgingUS/ Twitter - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/agingus​ LinkedIn - https://www.linkedin.com/company/aging​ Pinterest - https://www.pinterest.com/AgingUS/ Aging-US is published by Impact Journals, LLC please visit http://www.ImpactJournals.com​​ or connect with @ImpactJrnls Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM

Aging-US
Trending With Impact: Machine Learning Predicts Human Aging

Aging-US

Play Episode Listen Later Nov 5, 2021 6:36


Will you age quickly or slowly? Is it possible to predict how long you will live based on your genetics, lifestyle and other traits? In a new study, a team of researchers—from the National Institutes of Health's National Institute on Aging, University of California San Diego, University of Michigan, Consiglio Nazionale delle Ricerche, Azienda Sanitaria di Firenze, and ViQi, Inc.—sought to answer these questions by developing a novel framework designed to estimate human physiological age and aging rate. Their trending paper was published by Aging (Aging-US) in October 2021, and entitled, “Predicting physiological aging rates from a range of quantitative traits using machine learning”. “We present machine learning as a promising framework for measuring physiological age from broad-ranging physiological, cognitive, and molecular traits.” Full blog - https://www.mishablagosklonny.com/2021/11/05/trending-with-impact-machine-learning-predicts-human-aging/ Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.203660 DOI - https://doi.org/10.18632/aging.203660 Full Text - https://www.aging-us.com/article/203660/text Correspondence to: Luigi Ferrucci email: ferruccilu@grc.nia.nih.gov, David Schlessinger email: schlessingerd@grc.nia.nih.gov, Ilya Goldberg email: ilya@viqi.org and Jun Ding email: jun.ding@nih.gov Keywords: physiological aging rate, quantitative trait, machine learning, aging clock, mortality, personalized medicine About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at http://www.Aging-US.com​​ or connect with us on: SoundCloud - https://soundcloud.com/aging-us​ Facebook - https://www.facebook.com/AgingUS/ Twitter - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/agingus​ LinkedIn - https://www.linkedin.com/company/aging​ Pinterest - https://www.pinterest.com/AgingUS/ Aging-US is published by Impact Journals, LLC please visit http://www.ImpactJournals.com​​ or connect with @ImpactJrnls Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM

The Bio Report
Characterizing the Immunome at Scale

The Bio Report

Play Episode Listen Later Apr 29, 2021 23:51


When variants of the COVID-19 virus emerged in late 2020, it raised concerns about whether people already infected with the original virus, or vaccinated against it, would be able to generate a protective immune response that would confer protection against these new strains. Researchers at the National Institutes of Health's National Institute of Allergy and Infectious Diseases and Johns Hopkins University recently reported encouraging findings from a study that took a detailed look at the antibodies in the blood from COVID-19 patients. To do this, they used a deep immunomics technology platform developed by ImmunoScape. We spoke to Brian Abel, senior director of business development at ImmunoScape and lead of the company's COVID-19 Vaccine Task Force, about the COVID-19 study, the company's technology, and how it is being used to develop the next generation of immunotherapies.

Best Of The Bay
Neurological Impact of COVID-19 & Childhood Hunger

Best Of The Bay

Play Episode Listen Later Apr 12, 2021 29:46


Ryan Gorman hosts an iHeartRadio nationwide special featuring Dr. Walter Koroshetz, Director of the National Institutes for Health's National Institute of Neurological Disorders and Stroke, on the potential neurological impact of COVID-19. Also, Pamela Taylor, chief communications and marketing officer at Share Our Strength, the organization behind the No Kid Hungry campaign, joins the show to discuss the state of childhood hunger across the U.S.  Learn more about your ad-choices at https://www.iheartpodcastnetwork.comSee omnystudio.com/listener for privacy information.

The Talking DLD Podcast
Language Screening & Early Detection of DLD

The Talking DLD Podcast

Play Episode Listen Later Mar 5, 2021 54:55


Should Australia introduce universal screening for Developmental Language Disorder (DLD) ? How common is dyslexia co-occurring alongside DLD? In this episode of The Talking DLD Podcast we're talking language screening with special guest Dr.Tiffany P. Hogan, PhD CCC-SLP, Director of the Speech and Language (SAiL) Literacy Lab and Professor in the Department of Communication Sciences and Disorders at MGH Institute of Health Professions in Boston. In this episode Tiffany will: talk about language screening practices in the US for DLD discuss the implications of introducing mass language screening on service delivery explain the connection between dyslexia and DLD About DR Hogan Dr. Hogan studies the genetic, neurologic, and behavioral links between oral and written language development, with a focus on implementation science for improving assessment and intervention for young children with speech, language and/or literacy impairments. Her research is funded by the National Institutes of Health's National Institute on Deafness and Other Communication Disorders and the Department of Education's Institute of Education Sciences.  Dr. Hogan teaches online graduate courses in literacy assessment and intervention and leading literacy change. She is an advocate for children with communication disorders including Developmental Language Disorders, Dyslexia, and Speech Sound Disorders.   She is co-founder of the DLD informational website: www.dldandme.org, she hosts a podcast, SeeHearSpeak Podcast (www.seehearspeakpodcast.com), and she is an elected board member for the Society for the Scientific Studies of Reading.  Her career achievements have been acknowledged through receipt of numerous awards and fellowships including an Award for Early Career Contributions in Research and Lifetime Fellow bestowed by the American Speech-Language-Hearing Association, and a Faculty Excellence in Research Award from the MGH Institute. Find her on twitter (@tiffanyphogan), Facebook (sailliteracylab), Instagram (@seehearspeakpodcast) or the web (www.mghihp.edu/sail).  Resources Discussed in the Podcast Tools chart: https://charts.intensiveintervention.org/ascreening List of DLD screeners: https://docs.google.com/spreadsheets/d/1o5U6QSztiJb0qE_a0wjzPeWg7_816GmquEagQi0XPpo/edit Translational science paper: https://ila.onlinelibrary.wiley.com/doi/abs/10.1002/rrq.357 DLD & dyslexia paper: https://pubs.asha.org/doi/10.1044/2018_LSHSS-DYSLC-18-0049 Special journal issue on dyslexia for SLPs: https://academy.pubs.asha.org/2018/10/lshss-clinical-forum-what-slps-need-to-know-about-dyslexia/ Five ways speech-language pathologists can positively impact children with dyslexia: https://pubs.asha.org/doi/10.1044/2018_LSHSS-DYSLC-18-0102 SSDs and dyslexia: https://pubs.asha.org/doi/10.1044/2018_LSHSS-DYSLC-18-0008 Argument for screening language in schools:https://journals.sagepub.com/doi/full/10.1177/2372732219839075 Shortened argument for language screeners: https://dldandme.org/school-language-screening/ Paper on efficacy of classroom-based language stimulation program: Early ID of reading paper: https://mydigitalpublication.com/publication/?i=671218 Prevention of dyslexia paper: https://www.thereadingleague.org/wp-content/uploads/2021/01/TRLJ-Table-of-Contents-January-2021.pdf    

Science Signaling Podcast
The worst year ever and the effects of fasting

Science Signaling Podcast

Play Episode Listen Later Nov 15, 2018 33:29


When was the worst year to be alive? Contributing Correspondent Ann Gibbons talks to host Sarah Crespi about a contender year that features a volcanic eruption, extended darkness, cold summer, and a plague. Also on this week's show, host Meagan Cantwell talks with Andrea Di Francesco of the National Institutes of Health's National Institute on Aging in Baltimore, Maryland, about his review of current wisdom on fasting and metabolism. Should we start fasting—if not to extend our lives maybe to at least to give ourselves a healthy old age?  In a special segment from our policy desk, Deputy Editor David Malakoff discusses the results of the recent U.S. election with Senior Correspondent Jeffrey Mervis and we learn what happened to the many scientist candidates that ran and some implications for science policy. This week's episode was edited by Podigy. Download a transcript (PDF) Listen to previous podcasts. About the Science Podcast [Photo: Scott Suchman; Styling: Nichole Bryant; Music: Jeffrey Cook]