Podcasts about s1 s2

This discussion of Netflix's The Witcher Season 3 was recorded in June 2023 and originally released in July prior to the Hollywood writers' and actors' strikes. Elsa from the UK and James from the US join Alyssa for our pre-premiere discussion of Netflix's The Witcher Season 3. Very important bits include: our standout moments from Season 1 and 2, our characters to watch, and our wildest Season 3 predictions. [00:00] Cold Open [01:33] Introduction [04:48] Guest Introductions [09:34] S1 & S2 Recap [10:50] Standout Moments from S1 & S2 [16:22] S3 of The Witcher [30:31] Characters to Watch [40:30] Wildest S3 Predictions [46:16] Easter Eggs [52:25] Why You Should Watch S3 [55:55] Outro [56:55] End Credits The full episode transcript, show notes, merchandise store, and access to our social platforms are available at breakfastinbeauclair.com.

This is the final installment of my chat with the animator, artist, and publisher, Aaron Smith. He and his father have built a legacy full of intrigue, art, and, well...serial killers. Get bonus content on PatreonSupport this show http://supporter.acast.com/circumstance. Hosted on Acast. See acast.com/privacy for more information.

A month later we look back on the highs and lows of Season 1 of Netflix's Avatar and speculate on how they might do Season 2 including Toph! Join the From the Spirit World crew as they recap & review […]

In this episode, we chat with Aaron, a remarkable artist whose canvas tells more than just stories. We explore his journey, the strokes of genius defining his career, and his father's profound influence on his art. From haunting sketches to captivating paintings, Aaron's work is a testament to the power of legacy and the enduring nature of creativity. Join us as we unravel the layers behind each masterpiece! Get bonus content on PatreonSupport this show http://supporter.acast.com/circumstance. Hosted on Acast. See acast.com/privacy for more information.

Join us as we explore how the unassuming orange Volkswagon rabbit played a pivotal role in retracing the chilling steps of the Zodiac Killer and a scary encounter with suspect Arthur Leigh Allen. From anonymous phone calls to the letter sent to journalist Paul Avery, we unravel the threads that led to the creation of Zodiac, the groundbreaking book that forever changed the true crime genre. Get bonus content on PatreonSupport this show http://supporter.acast.com/circumstance. Hosted on Acast. See acast.com/privacy for more information.

Aaron Smith and I delve into the intriguing world of ciphers, letters, and phone calls. Our deep dive explores the impact of trauma—because, let's face it, most of us navigate life with some form of it. We discuss providing support to trauma victims, coping mechanisms, accepting the healing journey, and the conscious effort required to emerge stronger on the other side.And that's not all! We continue our riveting conversation about Robert Graysmith's account during his investigation of the Zodiac, the In-Nig-Matic Arthur Leigh Allen, the chilling case of the Trailside Killer, and more. Get bonus content on PatreonSupport this show http://supporter.acast.com/circumstance. Hosted on Acast. See acast.com/privacy for more information.

Join Professor Michael Solomon, Dr Kilian Brown and Dr Jacob Waller from Royal Prince Alfred Hospital in Sydney, Australia, for this special four part series on pelvic exenteration surgery for locally advanced and recurrent rectal cancer. Learn about these ultra-radical procedures which go beyond the traditional TME planes that we learn during surgical training, and into all compartments of the pelvis. Episode 3 outlines the radical technical approaches to posterior and laterally invasive tumours, including en bloc iliac vascular resection and reconstruction, as well as radical sacrectomy techniques. Each episode in this series features a different international guest surgeon. In episode 3, the RPA team are joined by Dr Oliver Peacock from the University of Texas MD Anderson Cancer Centre, USA. Technical descriptions and videos: Shaikh I, Holloway I, Aston W, Littler S, Burling D, Antoniou A, Jenkins JT; Complex Cancer Clinic St Mark's Hospital London. High subcortical sacrectomy: a novel approach to facilitate complete resection of locally advanced and recurrent rectal cancer with high (S1-S2) sacral extension. Colorectal Dis. 2016 Apr;18(4):386-92. doi: 10.1111/codi.13226. PMID: 26638828. https://pubmed.ncbi.nlm.nih.gov/26638828/ Brown KGM, Solomon MJ, Austin KKS, Lee PJ, Stalley P. Posterior high sacral segmental disconnection prior to anterior en bloc exenteration for recurrent rectal cancer. Tech Coloproctol. 2016 Jun;20(6):401-404. doi: 10.1007/s10151-016-1456-0. Epub 2016 Mar 21. PMID: 27000857. https://pubmed.ncbi.nlm.nih.gov/27000857/ Sutton PA, Solomon M, Sasidharan P, Lee P, Austin K. Abdominolithotomy sacrectomy for the management of locally recurrent rectal cancer: video vignette. Br J Surg. 2021 Aug 19;108(8):e257. doi: 10.1093/bjs/znab105. PMID: 34089593. https://pubmed.ncbi.nlm.nih.gov/34089593/ Drami I, Fletcher JA, Corr A, West MA, Aston W, Hellawell G, Burns EM, Jenkins JT. Total pelvic exenteration with 'high and wide' sacrectomy for recurrent rectal cancer: A video vignette. Colorectal Dis. 2022 Dec;24(12):1625-1626. doi: 10.1111/codi.16230. Epub 2022 Jul 18. PMID: 35730692. https://pubmed.ncbi.nlm.nih.gov/35730692/ References: Rajendran S, Brown KGM, Solomon MJ. Oncovascular surgery for advanced pelvic malignancy. Br J Surg. 2023 Jan 10;110(2):144-149. doi: 10.1093/bjs/znac414. PMID: 36427187. https://pubmed.ncbi.nlm.nih.gov/36427187/ Austin KK, Solomon MJ. Pelvic exenteration with en bloc iliac vessel resection for lateral pelvic wall involvement. Dis Colon Rectum. 2009 Jul;52(7):1223-33. doi: 10.1007/DCR.0b013e3181a73f48. PMID: 19571697. https://pubmed.ncbi.nlm.nih.gov/19571697/ Rogers AC, Jenkins JT, Rasheed S, Malietzis G, Burns EM, Kontovounisios C, Tekkis PP. Towards Standardisation of Technique for En Bloc Sacrectomy for Locally Advanced and Recurrent Rectal Cancer. J Clin Med. 2021 Oct 25;10(21):4921. doi: 10.3390/jcm10214921. PMID: 34768442; PMCID: PMC8584798. https://pubmed.ncbi.nlm.nih.gov/34768442/ van Kessel CS, Waller J, Steffens D, Lee PJ, Austin KKS, Stalley PD, Solomon MJ. Improving Surgical Outcomes in Pelvic Exenteration Surgery: Comparison of Prone Sacrectomy with Anterior Cortical Sacrectomy Techniques. Ann Surg. 2023 Jul 24. doi: 10.1097/SLA.0000000000006040. Epub ahead of print. PMID: 37485983. https://pubmed.ncbi.nlm.nih.gov/37485983/  ***Fellowship Application - https://forms.gle/5fbYJ1JXv3ijpgCq9*** Please visit https://app.behindtheknife.org/home to access other high-yield surgical education podcasts, videos and more.  If you liked this episode, check out our recent episodes here https://app.behindtheknife.org/listen

Hello Everyone! We're back from our unplanned Thanksgiving hiatus. As I mentioned at the start of the show, I had some unexpected family stuff occur and it pulled us away from being able to do the show. We're back though! And with that extra time, we used it to also watch what is currently available of Invincible Season 2. We tried to make this episode longer than usual to make up for the unplanned absence. Hope you enjoy our discussion. Next Time: Krampus Write to us and we'll read it on the show! HiMomPod@Gmail.com You can find both Jacob and I on these platforms: Instagram: @kevin0nline @⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Jacob_the_cookie⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ (@keii0n is now a private account) Threads: @keii0n Bluesky: @kevin0nline.bsky.social Twitter: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@kevin0nline⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ @⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠BlinkAdict⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Youtube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠itsumo⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠: https://www.youtube.com/channel/UCzGVl_JPv3ClWHd42A6pLdQ Check Out Jacob on Twitch: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠blink_mom

過去談到企業永續發展，大家的第一印象可能與道德相關，透過慈善捐款等公益活動就算善盡社會責任，然而隨著永續發展的概念愈來愈清晰，各種國際規範準則漸次問世，甚至已經成為法律。各企業面對永續要求，已經不再只是選擇加分，而是非做不可的必修學分。 歷經多年整合，國際財務報導準則基金會(IFRS Foundation)轄下的國際永續準則理事會(ISSB)2023年6月發布永續揭露準則第S1號「永續相關財務資訊揭露之一般規定」及第S2號「氣候相關揭露」，我國金管會也預定自2026年起，分三階段規範國內上市櫃企業逐步適用。這些新規範背後的意義是什麼？企業又應該如何面對這些新的規範？歡迎收聽本集節目。 本文節選自中廣新聞網《當地球發燒時》廣播2023.08.19 節目。 #氣候變遷 #永續發展 #IFRS

Elsa from the UK and James from the US join Alyssa for our pre-premiere discussion of Netflix's The Witcher Season 3. Very important bits include:  our standout moments from Season 1 and 2, our characters to watch, and our wildest Season 3 predictions. [00:00] Cold Open [01:24] Introduction [04:37] Guest Introductions [10:40] Standout Moments from S1 & S2 [16:12] S3 of The Witcher [30:21] Characters to Watch [40:31] ‘Tidings from Toussaint', Mid-Episode News Segment [44:41] ‘Dear Friend', Listener Call-in Segment [46:03] Wildest S3 Predictions [51:54] Easter Eggs [58:01] Why You Should Watch S3 [1:02:27] Outro & Credits The full episode transcript, show notes, merchandise store, and access to our social platforms are available at breakfastinbeauclair.com.

Subscriber-only episodeMy group of guests continue discussing the limited series inspired by Bridgerton, Queen Charlotte: A Bridgerton Story in this part 2 episode.  We talk relationships, story-building, and give it a Good reads rating among other topics.As in all of our review chats, there are spoilers of the series and the books (Bridgerton, S1-S2; Queen Charlotte: A Bridgerton Story novel by Julia Quinn & Shonda Rimes), so watch the series first (and read the book) if you don't want to be spoiled.We talked about:What we liked about the relationships between the charactersWhy Queen Charlotte is, so far, better than BridgertonShonda Rhimes storytelling technique and signature touchesOur Goodreads rating for the seriesThe Accidental Swipe is a steamy contemporary romance with a couple of jaded lovers, online dating hijinks, and a few fun Golden Girls references. Add it to your Goodreads want to read list, and subscribe to my newsletter to keep up with the latest on this fun story with HEA included!Contact Nerdy Romantics Podcast: https:// nerdyromanticspodcast.com for show notes Get a FREE romance eBook when you subscribe to my newsletter. Follow me on Instagram, Facebook, and TikTok Get premium episodes in your email or in your podcast feed. Have a show idea? Want to be on the show? Find out how at https://nerdyromanticspodcast.com/contact Thank you for listening!

Happy St. Patrick's Day! Our faves are making their way back to our screen and we couldn't be more excited. On todays episode, we're reflecting on some of the most intense moments from Powerbook II and sharing our predictions for the highly anticipated season 3. Grab a glass and join us for the season 1 & 2 recap. ________ Wine/Cocktail of the Night Cece: Rosè x 14 Hands Princess: Sauvignon Blanc x Bay Moon ________ Chat with us on social media! Cece: Twitter: _jadorececexo Instagram: _jadorececexo Princess: Twitter: @princess_vogue Instagram: @purelypicturesque --- Support this podcast: https://podcasters.spotify.com/pod/show/rewine--recap/support

Can you answer 15 questions about The Mandalorian on Disney+ ? This focuses on Season 1 and 2. And if you'd like to support Kidd's Kids and make a donation, visit https://kiddskids.org/donateThanks and be sure to subscribe and check out all of our episodes!

Y. M. Nelson and Nerdy Romantics guests Jen and new guest Perry dive into DC superhero Superman as we discuss CW TV Series Superman & Lois, Seasons 1 and 2. We get pretty nerdy as we go in depth on the show's storylines, characters, and culture, especially since Perry is an avid comic book reader and author. The Accidental Swipe is a steamy contemporary romance with a couple of jaded lovers, online dating hijinks, and a few fun Golden Girls references. Add it to your Goodreads want to read list, and subscribe to my newsletter to keep up with the latest on this fun story with HEA included!Support the showContact Nerdy Romantics Podcast: https:// nerdyromanticspodcast.com for show notes Get a FREE romance eBook when you subscribe to my newsletter. Follow me on Instagram, Facebook, and TikTok Get premium episodes in your email or in your podcast feed. Have a show idea? Want to be on the show? Find out how at https://nerdyromanticspodcast.com/contact Thank you for listening!

This is it! Albert and Jonesy return with their full retrospective and review of Andor, Season 1, then have a little fun as they speculate what Season 2 may bring! Feedback and Promotion: Subscribe on YouTube: Cantina Cast Send feedback and comments to hellothere@cantinacast.com Follow us on Twitter @TheCantinaCast Like us on Facebook: The Cantina Cast Follow us on Instagram: The Cantina Cast Follow us on Tumblr: Cantina Cast Discord Channel: Cantina Cast Channel Ear Glue Media: Web Site Cantina Cast: Web Site Pandora Link: Pandora Call or Text the Cantina Cast: 803-717-CAST Ear Glue Media YouTube: EGM Support the show: Cantina Cast Patreon page TeePublic Store

こんにちは。 ジェニのピカピカ日本語へようこそ。 今日の日本語学習は、「S1ですか、S2ですか」 これは雑誌（S1)ですか。新聞（S2)ですか？ 音声を聴いて学習してください。 Hello. Welcome to Jenni's Pika Pika Japanese. Today's Japanese study is "Is this S1 or S2?" Is this a magazine (S1)? Is this a newspaper (S2)? Please listen to the audio to learn. Hola. Bienvenido a Jenni's Pika Pika Japanese. La lección de japonés de hoy es "¿Esto es S1 o S2? ¿Es una revista (S1)? ¿Es un periódico (S2)? Escucha el audio y aprende.

Podcast #133 has arrived with special guest Jillian Hall! Listen as What We Watching returns as well as an in depth review of the new Disney+ film, Pinocchio (2022). Make sure to check out Newsly for all your podcast listening! Go to https://newsly.me and use the promo code TMPals to get a one month free premium subscription! 00:00 - Intro 01:10 - What We Watching? Jill's Watchlist: - Only Murders in the Building (Hulu, S1-S2, 2021-2022) - On the Count of Three (Hulu, 2022) Nabil's Watchlist: - The Resort (Peacock, S1, 2022) - Locke & Key (Netflix, S3, 2022) James' Watchlist: - The Lord of the Rings: The Rings of Power (Prime Video, S1, 2022) - Barbarian (Theaters, 2022) Marco's Watchlist: For All Mankind (Apple TV+, S1-S3, 2019-2022) Jaws IMAX Re-Release (Theaters, 1975) 32:51 - Review of, "Pinocchio" (2022) Overall Movie Pals Rating: 2/5 Stars 1:18:01 - Outro/How To Reach Us/What's Next? Please subscribe and leave a review! We appreciate you listening! Thank you to Michael Parkham for Designing Our Logo. Contact us at our email: themoviepalspodcast@gmail.com for any submissions for topics! Follow Us on Instagram: @moviepalspod Subscribe to us on: iTunes, Soundcloud, Google Podcasts, iHeartRadio & Spotify! Follow Us On Twitter: @moviepalspod - our podcast Twitter page (submit a topic!) @rufio1617 - James' Twitter @marcore - Marco's Twitter @nlothae - Nabil's Twitter Follow Us On Letterboxd: Rufio1617 - James Marcore83 - Marco Lothae - Nabil Follow Us On Facebook: Facebook.com/moviepalspod (once again submit a topic or movie!) Be sure to check out @waterfrontcomics for a variety of comics and collectibles!

こんにちは。 ジェニのピカピカ日本語へようこそ。 今日の日本語学習は「or を表す質問」＝「S1 か S2」です。 （例文） これは雑誌です「か」、新聞です「か」？ 音声を聞いて学習して下さい。

Season 3 starts off with our Pilot Episode. If you are a new listener, this is a great place to figure out who we are and why we are here. If you've already listened to S1 & S2, welcome back! Join Peter and Chris as they preview Season 3: Wizard of the Hood, the much-anticipated solo debut of Violent J.  Sit back and listen as we discuss the history of the songs that predated this album, debate the significance of the Wizard of Oz to popular culture and tackle important topics like how Intelligence and Violence was truly uncovered and the history of Delray.      Twitter: @JuggaloRWD IG: @JuggaloRWD Facebook: @JuggaloRWD  TikTok: @JuggaloRWD Website - www.JuggaloRewind.com    LinkTree - https://linktr.ee/juggalorwd    Email us - juggalorwd@gmail.com Call us - 810-666-1570 Additional music provided by Steve O of the IRTD.     Powered by the 20x20 Apparel.     All music played is owned by the respective publishers and copywrite holders and is reproduced for review purposes only under fair use.  #ForTheJuggaloCulture

Hello. Welcome to Jenni's Pika Pika Japanese. Today's Japanese lesson is "S1 desu ka, S2 desu ka." For example, you can use it in sentences like this. Koreha Magazin(S1) Desuka? Shinbun (S2) desuka? Listen to the podcast to learn. According to the 24 solar terms of the Japanese calendar, the period from July 7 to around July 22 is called "Shosho,” which means "small heat. Shosho is the time when the rainy season is over, cicadas begin to cry, and the heat is in full swing, and summer festivals are held in various places. This weekend, the Gion Festival, which I mentioned earlier, is being held in grand style. From the beginning of July until last week, Hakata in Kyushu was the site of the Hakata Gion YamaGasa festival. Hakata Gion YamaGasa is a Shinto ritual dedicated to Susanoo-no-Mikoto (GionGuu) enshrined at Kushida Shrine, the main deity of Hakata, and has been held since 1241 (Ninji 2) of the Kamakura period. The festival has been registered as a UNESCO Intangible Cultural Heritage. Various events will be held every day from July 1, when the decorated mountain is open to the public, to July 15, when the festival is over. Hola. Bienvenidos al japonés de Jenni Pika Pika. La lección de japonés de hoy es "S1 desu ka, S2 desu ka". Por ejemplo, puedes usarlo en frases como esta. Korewa Magazin(S1) ¿Desuka? Shinbun (S2) desuka? Escuche el podcast para aprender. Según los 24 términos solares del calendario japonés, el periodo que va del 7 al 22 de julio, aproximadamente, se llama "Shousho", que significa "pequeño calor". El Shousho es la época en la que se acaba la temporada de lluvias, las cigarras empiezan a llorar y el calor está en pleno apogeo, y se celebran festivales de verano en varios lugares. Este fin de semana se celebra a lo grande el Festival de Gion, que ya he mencionado. Desde principios de julio hasta la semana pasada, Hakata, en Kyushu, fue el lugar donde se celebró el festival Hakata Gion YamaGasa. Hakata Gion YamaGasa es un ritual sintoísta dedicado a Susanoo-no-Mikoto (GionGuu) consagrado en el santuario de Kushida, la principal deidad de Hakata, y se celebra desde 1241 (Ninji 2) del periodo Kamakura. El festival ha sido registrado como Patrimonio Cultural Inmaterial de la UNESCO. Desde el 1 de julio, fecha en la que la montaña decorada se abre al público, hasta el 15 de julio, fecha en la que finaliza el festival, se celebran diversos actos todos los días. こんにちは。 ジェニのピカピカ日本語へようこそ。 今日の日本語学習は、「S1ですか、S2ですか」 例えばこのような文章に使えます。 これは雑誌（S1)ですか。新聞（S2)ですか？ Podcastを聴いて学習してください。 さて、日本の暦二十四節気では7月7日から22日頃までの今を小さな暑さと書いて「小暑」と言います。小暑とは、梅雨が明け、セミが泣き始めて暑さが本格的になる頃で、夏祭りも各所で行われます。 この週末は以前にご紹介した祇園祭が盛大に行われていますが、7月の最初から先週まで九州の博多では博多祇園山笠が行われました。 博多祇園山笠は博多の総鎮守・櫛田神社にまつられる素戔嗚尊すさのおのみこと(祗園宮)に対して奉納される神事で鎌倉時代の仁治２年（1241年）から続くユネスコ無形文化遺産にも登録されているお祭りで、7月1日の飾り山一般公開から15日の追い山まで連日さまざまな行事が行われます。

Welcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is: Murphyjitsu: an Inner Simulator algorithm, published by CFAR!Duncan on June 30, 2022 on LessWrong. Epistemic status: Firm The concepts underlying the Inner Simulator model and the related practical technique of Murphyjitsu are well-known and well-researched, including Kahneman's S1/S2, mental simulation, and mental contrasting. Similarly, the problems that this unit seeks to address (such as optimism bias and the planning fallacy) have been studied in detail. There is some academic support for specific substeps of Murphyjitsu (e.g. prospective hindsight), and strong anecdotal support (but no formal research) for the overall technique, which was developed through iterated experimentation and critical feedback. See the Further Resources section for more discussion. Claim: there is a part of your brain (not a specific physical organ, but a metaphorical one) which is keeping track of everything. It's not actually recording all of the information in a permanent fashion. Rather, what it's doing is building up a consistent, coherent model of how things work. It watches objects fall, and builds up anticipations: heavy objects drop straight down, lighter ones flutter, sometimes wind moves things in chaotic ways. It absorbs all of the social interactions you observe, and assembles a library of tropes and clichés and standard patterns. Whenever you observe something that doesn't match with your previous experience, you experience (some amount of) surprise and confusion, which eventually resolves in some kind of update. You were surprised to see your partner fly off the handle about X, and now you have a sense that people can be sensitive about X. You were surprised by how heavy the tungsten cube was, and now you have a sense that objects can sometimes be really, really dense. You can think of this aggregated sense of how things work as a simulated inner world—a tiny, broad-strokes sketch of the universe that you carry around inside your head. When you move to catch a falling pen, or notice that your friend is upset just by the way they entered the room, you're using this inner simulator. It's a different sort of processing from the explicit/verbal stuff we usually call "thinking," and it results in a very different kind of output. Inner Simulator: Intuitive; part of the cluster we label "System 1" Outputs feelings, urges, reflexes, and vivid predictions Learns well from experience and examples; responds to being shown Good at social judgment, routine tasks, and any situation where you have lots of experience and training data Explicit/Verbal models Analytical; part of the cluster we refer to as "System 2" Outputs arguments, calculations, and other legible content Learns well from facts and explanations; responds to being told Good at comparisons and reframings (e.g. noticing that $1/day ≈ $350/year) We don't have to think about how to catch a falling pen, or send explicit instructions to our body about how to move to do it, because our inner simulator "knows" how falling objects move, and it "knows" how to make our hand go to a particular place. Similarly, it knows what facial expressions mean, what it's like to drive from home to work, and what sorts of things tend to go wrong given a set of circumstances. It's a powerful tool, and learning how to access it and when to trust it is one of the first steps to becoming a whole-brain thinker. That's not to say that your inner simulator is superior to your explicit model maker—each has both strengths and weaknesses, and can be either the right tool or the wrong one, depending on the situation. In any given moment, you're probably receiving feedback from both of these “advisors,” as well as other sources of information like your friends or the internet. In a sense, it's your job to balance the competing recommendations from all of th...

Link to original articleWelcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is: Murphyjitsu: an Inner Simulator algorithm, published by CFAR!Duncan on June 30, 2022 on LessWrong. Epistemic status: Firm The concepts underlying the Inner Simulator model and the related practical technique of Murphyjitsu are well-known and well-researched, including Kahneman's S1/S2, mental simulation, and mental contrasting. Similarly, the problems that this unit seeks to address (such as optimism bias and the planning fallacy) have been studied in detail. There is some academic support for specific substeps of Murphyjitsu (e.g. prospective hindsight), and strong anecdotal support (but no formal research) for the overall technique, which was developed through iterated experimentation and critical feedback. See the Further Resources section for more discussion. Claim: there is a part of your brain (not a specific physical organ, but a metaphorical one) which is keeping track of everything. It's not actually recording all of the information in a permanent fashion. Rather, what it's doing is building up a consistent, coherent model of how things work. It watches objects fall, and builds up anticipations: heavy objects drop straight down, lighter ones flutter, sometimes wind moves things in chaotic ways. It absorbs all of the social interactions you observe, and assembles a library of tropes and clichés and standard patterns. Whenever you observe something that doesn't match with your previous experience, you experience (some amount of) surprise and confusion, which eventually resolves in some kind of update. You were surprised to see your partner fly off the handle about X, and now you have a sense that people can be sensitive about X. You were surprised by how heavy the tungsten cube was, and now you have a sense that objects can sometimes be really, really dense. You can think of this aggregated sense of how things work as a simulated inner world—a tiny, broad-strokes sketch of the universe that you carry around inside your head. When you move to catch a falling pen, or notice that your friend is upset just by the way they entered the room, you're using this inner simulator. It's a different sort of processing from the explicit/verbal stuff we usually call "thinking," and it results in a very different kind of output. Inner Simulator: Intuitive; part of the cluster we label "System 1" Outputs feelings, urges, reflexes, and vivid predictions Learns well from experience and examples; responds to being shown Good at social judgment, routine tasks, and any situation where you have lots of experience and training data Explicit/Verbal models Analytical; part of the cluster we refer to as "System 2" Outputs arguments, calculations, and other legible content Learns well from facts and explanations; responds to being told Good at comparisons and reframings (e.g. noticing that $1/day ≈ $350/year) We don't have to think about how to catch a falling pen, or send explicit instructions to our body about how to move to do it, because our inner simulator "knows" how falling objects move, and it "knows" how to make our hand go to a particular place. Similarly, it knows what facial expressions mean, what it's like to drive from home to work, and what sorts of things tend to go wrong given a set of circumstances. It's a powerful tool, and learning how to access it and when to trust it is one of the first steps to becoming a whole-brain thinker. That's not to say that your inner simulator is superior to your explicit model maker—each has both strengths and weaknesses, and can be either the right tool or the wrong one, depending on the situation. In any given moment, you're probably receiving feedback from both of these “advisors,” as well as other sources of information like your friends or the internet. In a sense, it's your job to balance the competing recommendations from all of th...

Hello. Welcome to Jenni's Pika Pika Japanese. Today's Japanese study is "S1 or S2? Is this a magazine (S1) or a newspaper (S2)? Please listen to the podcast to learn. Well, the temperature in Tokyo today is 36.4 degrees Celsius, the hottest day in June. Such heat makes you want to go to the beach, but if you can't take a break to go to Okinawa, how about Zushi Marina, which is only an hour away from the center of Tokyo? You will definitely feel refreshed if you have a meal while looking at the sea and yachts, or spend a relaxing night at a hotel. Hola. Bienvenido a Jenni's Pika Pika japonés. El estudio japonés de hoy es "¿S1 o S2? ¿Es una revista (S1) o un periódico (S2)? Escuche el podcast para aprender. Hoy la temperatura en Tokio es de 36,4°C, el día más caluroso de junio. Con tanto calor apetece ir al mar, pero si no puedes tomarte un respiro para ir a Okinawa, ¿qué tal el puerto deportivo de Zushi, al que sólo se tarda una hora en llegar desde el centro de Tokio? Sin duda, se sentirá renovado tras una comida y una relajante estancia en un hotel mientras observa el mar y los yates. こんにちは。 ジェニのピカピカ日本語へようこそ。 今日の日本語学習は、「S1かS2か」です。 これは雑誌（S1)ですが、新聞(S2)ですか。 Podcastを聞いて学習してください。 さて、今日の東京の気温は36.4度と6月としては一番暑い日になっています。 こんなに暑いと海に行きたくなりますが、沖縄に行くにはなかなか休みも取れないという場合には、都心から来るまで1時間程度で到着する逗子マリーナなどはいかがでしょうか？ 海やヨットを見ながら食事をしたり、ホテルで1泊ゆったりとしたらリフレッシュできること間違いなしです。

This week we forge for food, search for hidden cameras and channel our inner “Ben Folds” as we cover two seasons of The Wilds on Prime Video. We breakdown each character, the highs and lows of each season, and where we think the show is headed. As always, we end with our SOTW (57:27).

Place your bet by submitting a story you'd like the BOOKIE take on to: bookiepodcast@gmail.com

Join Christian and Jamie as one returns from vacation refreshed and recharged to talk some soccer! They briefly preview the upcoming USWNT friendlies before develing into an exciting and engaging start of the season for the San Diego Wave. As Jamie always says, come ride the wave! Follow us on Twitter to ask us questions that we can answer on the pod at SurfBreakPod and on Instagram for live takeovers, fun photos from gamedays, and other goofy stuff at surfbreakpod. We appreciate your support as we start this fun project!

接續上集！細聊停更期看的8部韓國戀愛實境秀

Esteemed members of the Ton,Welcome to the tenth episode of the What the Austen? podcast! I'm your host Izzy, and I am joined by my friend and fellow Janeite Martha from @marthabethanreads. In anticipation for the new season which airs next month, in this episode we will be discussing Bridgerton! We will specifically focus on Season 1 of the the Netflix series which is based on Julia Quinns book The Dunk and I (Book 1 in the Bridgerton series), but we will also discuss the other books in the series and our expectations for Season 2. If you watched season 1 last year and want to join the discussion,  or if you want to join us in getting excited for the new season which comes out next month! tune in. NOTE: BIG SPOILER ALTERS FOR BOTH THE BOOKS AND SEASON 1. Julia Quinns Bridgerton: The Duke and I: Bridgerton Family, Book 1Book | Audiobook (Audible) Youtube videos on Race and Diversity in Bridgerton: The World According to Chyna - The Unspoken Racism & Colorism in BridgertonThe Feminine Fancy - My Unpopular Opinions About "Bridgerton"This podcast is about Janeites coming together, discussing Jane Austen's work, and having a few laughs along the way. We really enjoyed making this episode and we hope you like it. Please follow and subscribe to keep up with all the upcoming episodes.Buzzsprout - Let's get your podcast launched! Start for FREEAudible | 30 day free trial Izzy's recommendation: The Jane Austen Collection: An Audible Original Drama Support the show

I review and breakdown the series Quintessential Quintuplets both season 1 and season 2! Check us out facebook and Winnin Rome on youtube! --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/tenmen/support

On the season premier for Story n Things Season TWO, Yajaira and Cheli discuss the first and second season of The Witcher on Netflix. The story was originally written by Andrzej Sapkowski. Join them as they gush over Henry Cavill, Yennefer, Ciri and Jaskier!

Aloha Food Lovers! Food Wars the well-known ecchi, life-of-slice, food anime. Our dad hasn't watched many animes but this is his favorite one (wonder why

Welcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is: RadVac Commercial Antibody Test Results, published by johnswentworth on the LessWrong. Background: Making Vaccine Results are in from the commercial antibody tests. Both my girlfriend and I came back negative - the test did not detect any Spike antibody response in the blood. This post will talk about how I'm updating based on these results, and the next steps. Here's our timeline so far; more info on the vaccine is in the original post and the radvac whitepaper: We've taken five doses, spaced apart weekly (on Tuesdays). The first three doses only included six of the nine peptides, due to delays from the manufacturer. (Spike 660, Spike 1145, and Orf1 5471T were the three missing.) The blood draw for this test took place the day after the fifth dose. I expect this is too soon to notice significant impact from the last two doses; vaccines in general seem to typically take 2-3 weeks to kick in, and that is my expectation for this one as well. (Also, it was an "IgG antibody test", and WebMD says these antibodies typically take about 2 weeks to show up after covid symptoms show from an actual infection.) This is intended to mainly be a test of the first three doses. The test apparently used the "DiaSorin Liaison(R) SARS-CoV-2 S1/S2 IgG assay" (I didn't know this until the results came in). According to the FDA, it has about 92% sensitivity and 99% specificity. The "S1/S2" part indicates that it's testing for response to the S1 and S2 subunits of the spike protein - together, these are essentially the whole spike protein. Important thing to notice: the test was looking for Spike antibodies, and two of our three missing peptides were Spike peptides. Indeed, there were only 3 Spike peptides among the full 9, so with two missing, we only had one Spike peptide in our first three doses. (The rest target other parts of the virus.) So that makes the test significantly less useful than it would otherwise be, and makes me more inclined to get another test in 2-3 weeks when the doses with the other three peptides have had time to kick in. How I'm Updating In the original post, I called this test "searching under the streetlamp". It wasn't super likely to come back positive even assuming the vaccine worked as intended, but it was relatively cheap and easy to run the test, so it was our first check. Given the missing Spike peptides and the test only checking against Spike, it was even more likely to come back negative than I originally estimated. In Jacob's prediction questions, I gave roughly a 25% chance that a commercial antibody test would pass for most people, given three doses and all 9 peptides. I gave the vaccine about 75% chance of working overall, distributed over several different possible worlds. In this specific scenario, it's clear that the prior on test passing should be even lower. (Reminder on the possible worlds: the vaccine could induce antibody response in the blood and mucus, only mucus, or not at all. It could induce T-cell response separate from antibody response. It could work sometimes, much like how the first dose of commercial mRNA vaccines tend to work in 75% or 85% of people, and in that case I expect more doses/more time to make it work more often.) After updating on the results, I'm down to about 60-70% chance of working overall. Unfortunately this test just didn't give us very much information - at least about the vaccine working. Aside from the test result, we do have one more small piece of information to update on: I was quite congested for 1-2 days after the most recent three doses (and I was generally not congested the rest of the week). That's exactly what we'd expect to see if the vaccine is working as intended, and it's pretty strong evidence that it's doing something. Updating on both that and the test results, I'm at ~70% that it works overall...

No, Your eyes are not deceiving you! We've come back with our reviews of Tangled The Series... Or is it Rapunzel's Tangled Adventure? Either way Jacob and Drew talk about their thoughts on Season 1 in this episode and what they are looking forward to in Season 2! Join us on this adventure, won't you? Facebook - https://www.facebook.com/TheCelCast Twitch - https://www.twitch.tv/thecelcastgaming YouTube - https://www.youtube.com/channel/UCQcGNpWEc5qP7oKkxPWQEsw Twitter - https://twitter.com/cast_cel Instagram - https://www.instagram.com/thecelcast/   Apple Podcasts - https://podcasts.apple.com/us/podcast/id1452118040 Google Play - https://podcasts.google.com/feed/aHR0cHM6Ly90aGVjZWxjYXN0LnBvZGJlYW4uY29tL2ZlZWQueG1s Stitcher - https://www.stitcher.com/show/the-cel-cast Spotify - https://open.spotify.com/show/4ETrW9WhJ44uLhr4bU03uK   This Podcast is apart of Pop Americana, For more great shows like this one visit https://popamericana.wixsite.com/popamericana    and    This Podcast is apart of the Culture Box, For more great shows like this one visit https://culturebox.media

Banyak mahasiswa yang bingung tentang lingkup penelitian yang akan dilakukan. Ini adalah opini saya tentang S1, S2, dan S3.

Hai semuaaa

Good day! Here's another episode for PARA PO! Most of the informations are taken from: Animelist.com This is a non-profit podcast

We welcome Matt Goldman. Matt was the first credited writer on "Seinfeld," other thank Larry David and Jerry Seinfeld. He worked as a Writer/Story Editor on "Seinfeld" for Season 1 and Season 2. Matt is an Emmy Award Winning Writer and New York Times Best-Selling Author. He has written for several hit shows including, "Ellen," "Wizards of Waverly Place," "Call Your Mother" and "Dirk Gently's Holistic Detective Agency." Social: https://linktr.ee/ThisThirsty Matt: https://www.mattgoldman.com "This Podcast Is Making Me Thirsty" is The Place to Be for "Seinfeld" fans. We are the #1 destination for all things "Seinfeld," the last, great sitcom of our time.

CaBreon Wise reacts to Kevin Durant's huge Game 5 performance versus the Milwaukee Bucks which includes a rant on a special person, the remainder of NBA semifinal playoff games, and the unexpected NBA news from Wednesday morning! The episode closes with his NBA playoff pick 'ems and a special CaBreon's Closer. Make sure to follow the podcast's official Instagram and Twitter pages: Instagram: @thewisetalkpodcast Twitter: @WiseTalkPodcast --- Support this podcast: https://podcasters.spotify.com/pod/show/wise-talk-podcast/support

There's still some stutters smh I've made the sound design a little more better now. Information taken from: https://myanimelist.net/ This is a Non-profit Podcast

Hi, selamat datang kembali di segmen Talk and Share. Pada podcast kali ini saya bersama Aprilia Hapsari, penerima Beasiswa Unggulan Berprestasi dari Kemendikbud. Di podcast ini April berbagi apa saja persyaratan yang harus dipenuhi agar bisa lolos beasiswa Unggulan dari Kemendikbud. Untuk tahu lebih lanjut, silahkan simak podcastnya sampai selesai. Semoga bermanfaat.

On the first of a four part series of Pop Goes To The Couch, Andy Atherton is joined by Shawn Kidd, Scott Shifflett & Tim Capel to discuss the series Cobra Kai. The guys deep dive and break down Seasons 1 & 2 before giving their thoughts on Episode 1 of Season 3 "Aftermath". So after you binge the latest series, give a listen and don't forget one to post one of those hash browns when you do.

Maaandooo! This week we discuss the first season of The Mandalorian as well as the season premier of season 2. *SPOILER ALERT*

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.13.337212v1?rss=1 Authors: Anand, G. S., Palur, R., Tulsian, N. K., Samsudin, F., Qian, X., Purushotorman, K., Yue, G., McQueen, M. K., Lescar, J., Bond, P., McAry, P. A. Abstract: The Spike (S) protein is the main handle for SARS-CoV-2 to enter host cells through surface ACE2 receptors. How ACE2 binding activates proteolysis of S protein is unknown. Here, we have mapped the S:ACE2 interface and uncovered long-range allosteric propagation of ACE2 binding to sites critical for viral host entry. Unexpectedly, ACE2 binding enhances dynamics at a distal S1/S2 cleavage site and flanking protease docking site ~27 [A] away while dampening dynamics of the stalk hinge (central helix and heptad repeat) regions ~ 130 [A] away. This highlights that the stalk and proteolysis sites of the S protein are dynamic hotspots in the pre-fusion state. Our findings provide a mechanistic basis for S:ACE2 complex formation, critical for proteolytic processing and viral-host membrane fusion and highlight protease docking sites flanking the S1/S2 cleavage site, fusion peptide and heptad repeat 1 (HR1) as allosterically exposed cryptic hotspots for potential therapeutic development. Copy rights belong to original authors. Visit the link for more info

ORIGINAL POSTING: SEPTEMBER 29, 2019 Your hosts for today: Mia, Chantal, and special guest Dylan We're putting our spots on and getting our claws out to discuss the superhero transformations and relationships in Miraculous Ladybug! YouTube link: https://www.youtube.com/watch?v=eSGj6RcJT80 Dylan's YouTube Channel: https://www.youtube.com/channel/UCPa8oH00kixAXylkNthPgdg Sub to the Q4U Channel: https://www.youtube.com/channel/UCBfT61A-Pnc53sgpE3CieqQ Follow us on Twitter: https://twitter.com/queue_gals

ORIGINAL POSTING: JUNE 15, 2019 Your hosts for today: Mia, Chantal, Erica We discuss our first sports anime on this show! Batter up! It's time to find out if first-year high school student, Eijun Sawamura, is able to become his high school team's ace pitcher! YouTube link: https://www.youtube.com/watch?v=QHMqOzwDcrs Sub to the Q4U Channel: https://www.youtube.com/channel/UCBfT61A-Pnc53sgpE3CieqQ Follow us on Twitter: https://twitter.com/queue_gals

Resources:ADCES resources for sick day management: DiabetesEducator.org/SickDay.This episode was provided by Ascensia Diabetes Care, Makers of the CONTOUR®NEXT Brand of Blood Glucose Meters and Test Strips.  To learn more about the accuracy of CONTOUR®NEXT Brand Meters and receive sample for your clients, visit CONTOURNEXTPRO.com.References:Butler, S.O., Btaiche, I.F. & Alaniz, C. (2005) Relationship between hyperglycemia and infection in critically ill patients.  Pharmacotherapy. 25(7), 963-76. https://doi.org/10.1592/phco.2005.25.7.963 Carey,l. et al. (2018) Risk of Infection in Type 1 and Type 2 Diabetes Compared With the General Population: A Matched Cohort Study. Diabetes Care 2018 41(3): 513-521.Kim, E.J et. al. (2019) Diabetes and the Risk of Infection A National Cohort Study. Diabetes and Metabolism Journal, 804-814.  DOI: https://10.4093/dmj.2019.0071Peleg A, et al. (2007).  Common Infections in Diabetes: Pathogenesis, Management and Relationship to Glycaemic Control. Diabetes/Metabolism Research and Review 2007;(23) 3–13Casqueiro, J. et al.  Infections in patients with diabetes mellitus: A review of pathogenesis.  Indian Journal of Endocrinology and Metabolism 2012 (16 Suppl. 1):S27–S36Ketoacidosis (DKA). American Diabetes Association. http://www.diabetes.org/living-with-diabetes/complications/ketoacidosis-dka.html. Accessed May 20, 2020. Brutsaert, E (2019). Diabetic ketoacidosis (DKA). Merck Manual Professional Version. http://www.merckmanuals.com/professional/endocrine-and-metabolic-disorders/diabetes-mellitus-and-disorders-of-carbohydrate-metabolism/diabetic-ketoacidosis-dka. Accessed May 20, 2020.Tonyushkina, K. et al. (2009) Glucose Meters: A Review of Technical Challenges to Obtaining Accurate Results.  Journal of Diabetes Science and Technology. 3(4): 971–980. Maahs, D.M. et al. (2015) Effect of Acetaminophen on CGM Glucose in an Outpatient Setting.  Diabetes Care 2015 (38) e158-e159.  https://doi.org/10.2337/dc15-1096Centers for Disease Control and Prevention. (2020, March). Managing Sick Days. Retrieved from www.cdc.gov/diabetes/managing/flu-sick-days.html.Noti J. D. et al. (2013). High Humidity Leads to Loss of Infectious Influenza Virus from Simulated Coughs, PLoS ONE 8(2): e57485. https://doi.org/10.1371/journal.pone.0057485, American Diabetes Association (2020, Jan).  Introduction: Standards of Medical Care in Diabetes—2020 Diabetes Care 2020 Jan; 43(Supplement 1): S1-S2. https://doi.org/10.2337/dc20-Sint Retrieved from (https://care.diabetesjournals.org/content/43/Supplement_1)

Thank you for joining us for our 2nd Cabral HouseCall of the weekend! I’m looking forward to sharing with you some of our community’s questions that have come in over the past few weeks… Let’s get started!    Anthony: Been taking EN's Digestive Enzyme for almost a year now daily. I understand that the body can become reliant and produce less of its own enzymes because of exogenous enzymes. Given that I did the CBO and have a clean OAT in the re-test, with the occasional reflux/burping -- what are the best ways to wean off so I don't have to rely on them? Currently taking 1 every meal and would prefer to not carry them around and be "dependent." Thank you Dr. Cabral! Deb: What approach can be made to calm low back nerve pain? I have a S1-S2 that is degenerating and can press the nerves in the lower back against my spine. Western medicine wants to do back surgery that had a 60% chance of 80% or more relief. This is not an option for me. I still exercise and try to eat right. But at night have nerve pain that can have a dull spasm running up and down my legs which will wake me from a sound sleep. Need your thoughts Salil: Do you have any free courses? Jimmy: Hi Dr Cabral, I had a CT scan on my spine (not because of any real pain, it's a long story but basically I had one) and it came back that I had a minor wedge fracture of the C6 and C7 spine.The Doctor said this could be from degenerative bone disease. Every now an then I will get a shooting pain in my neck and its very painful, but it happens very infrequently. I just wondered if there is anything I could do to combat this, apparently it's normal as we get older that the spine can start to decay, I wonder if it's my posture of diet that's making it worse though? I am only in my twenties so not old. Any tips on how to heal or combat this? Thanks Dr.Cabral Donna: Dr. Cabral, I appreciate you being a voice to educate thousands of people so that they can make informed decision to improve their overall health and to stay healthy.I've been watching The Truth About Vaccines. Could you do a future podcast to give us the understanding between being immunized or vaccinated? Also, some insight into the ingredients in vaccines and how they can play a role in our health. Finally, can you teach us how to detox our bodies from any harmful substances that may be injected into us from vaccines whether we receive them by choice or by forced mandates. Grateful to hear your knowledge on this topic. Sincerely, DC Anonymous: Hi Dr. Cabral, Thank you for all you do. I have three very embarrassing symptoms that have been bothering me off and on for years. I don’t know if they’re related. The first is a bad smell coming from my vaginal area. I try to follow all recommended advice (breathable fabrics, loose fitting clothes, etc.) but it starts almost immediately after showering and won’t go away. I also have extremely smelly gas. It will last for a few days to a week. It usually comes back every few weeks. I haven’t been able to connect it back with a particular food.Lastly, I have a lot of pain/itchiness around my anus. I have switched to gentle soap, using a bidet and hypo-allergenic toilet paper. It usually bothers me the most after I wipe with toilet paper but will also irritate me at night.I look forward to any insight you may have! James: Hi Dr Cabral, I asked a question a while back about healthy bulking and your answer really helped. Vata body type here so had to be a bit more diligent when deciding how to bulk, anyway, it's going well. I'll be transitioning into a cut in a few months when I reached my desired pre-cut weight goal, and my question was simply a reverse of my old one: How can I cut effectively and efficiently? There's not too much information out there on how to cut, mainly only how to bulk so I wondered if you could point me in the right direction on how I should cut for best results, obviously I want to lose mainly fat and very little muscle. I've heard just go on a slight calorie deficit? Is it that simple? I should mainly be reducing carbs right? Any tips? Thanks Doc, James Thank you for tuning into this weekend’s Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right! - - - Show Notes & Resources:  http://StephenCabral.com/1584 - - - Dr. Cabral's New Book, The Rain Barrel Effect https://amzn.to/2H0W7Ge - - - Join the Community & Get Your Questions Answered: http://CabralSupportGroup.com - - -   Dr. Cabral’s Most Popular Supplements: > “The Dr. Cabral Daily Protocol” (This is what Dr. Cabral does every day!) - - - > Dr. Cabral Detox  (The fastest way to get well, lose weight, and feel great!) - - - > Daily Nutritional Support Shake  (#1 “All-in-One recommendation in my practice) - - - > Daily Fruit & Vegetables Blend  (22 organic fruit & vegetables “greens powder”) - - - > CBD Oil  (Full-spectrum, 3rd part-tested & organically grown) - - - > Candida/Bacterial Overgrowth, Leaky Gut, Parasite & Speciality Supplement Packages - - - > See All Supplements: https://equilibriumnutrition.com/collections/supplements  - - -   Dr. Cabral’s Most Popular At-Home Lab Tests: > Hair Tissue Mineral Analysis (Test for mineral imbalances & heavy metal toxicity) - - - > Organic Acids Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Thyroid + Adrenal + Hormone Test  (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Adrenal + Hormone Test (Run your adrenal & hormone levels) - - - > Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Omega-3 Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - > Stool Test (Use this test to uncover any bacterial, h. Pylori, or parasite overgrowth) - - - > Genetic Test (Use the #1 lab test to unlocking your DNA and what it means in terms of wellness, weight loss & anti-aging) - - - > Dr. Cabral’s “Big 5” Lab Tests (This package includes the 5 labs Dr. Cabral recommends all people run in his private practice) - - -

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.06.03.130559v1?rss=1 Authors: Zhou, J., Lin, Y., Huynh, T., Noguchi, H., Bush, J., Pleasure, S. Abstract: Callosal projections from primary somatosensory cortex (S1) are key for processing somatosensory inputs and integrating sensory-motor information. How the callosal innervation pattern in S1 is formed during early postnatal development is not clear. We found that the normal termination pattern of these callosal projections is disrupted in cortex specific NMDAR mutants. Rather than projecting selectively to the primary/secondary somatosensory cortex (S1/S2) border, axons were uniformly distributed throughout S1. In addition, the density of this projection increased over postnatal life until the mice died by P30. By combining genetic and antibody-mediated loss of function, we demonstrated that it is NR2B-containing NMDA receptors in target S1 that mediate this guidance phenotype, thus playing a central role in interhemispheric connectivity. Furthermore, we found that this function of NMDA receptors in callosal circuit formation is independent of ion channel function and instead depends on interactions with EPHRIN-B/EPHB. Thus, NMDAR cooperates with EPHRIN-B/EPHB in target S1 to control the formation callosal circuits by acting as an accessory axon guidance receptor modulating EPH-dependent repulsion. Copy rights belong to original authors. Visit the link for more info

Your daily COVID-19 LST Report: — An analysis of ultraviolet-C (UVC) decontamination of N95 respirators coated in MRSA or a bacteriophage found high variability of viral or bacterial persistence by different locations on the respirators and reduction levels that did not meet the criteria for decontamination. — The cellular protease Furin, was found to cleave the SARS-CoV-2 S protein S1/S2 multibasic site, which mediates cell to cell fusion and entry into human lung cells. Thus, Furin is suggested for therapeutic potential. — In a recent case report, a 47 year old man died from small bowel perforation from acute bowel ischemia secondary to COVID-19. The ischemia was characterized by yellow discoloration, necrosis, with patent mesenteric vasculature, which draws attention to direct tissue injury in the gastrointestinal tract from SARS-CoV-2 and possible microvascular thrombosis. — Of the 55 imported cases of COVID-19 detected through mandatory testing in Brunei, almost half were asymptomatic upon entry suggesting that symptom-based screening at entry points will likely miss a large proportion of cases. — Visit COVID19LST.org for our full report with links to the articles. — Reach out to us at: contact@covid19lst.org --- Support this podcast: https://anchor.fm/covid19lst/support

Favorite anime of 2019: 00:00:00-00:21:54 Most anticipated anime of 2020: 00:21:54-00:28:19 Waifu - Froppy: 00:28:19-00:36:09 Seasonal Anime (Spoilers) My Hero Academia S4E18: 00:36:27-00:44:57 Demon Slayer S1E17: 00:44:57-00:49:58 Other Anime We're Watching (Spoilers) JoJo's Bizarre Adventure S1E7-23: 00:48:58-00:54:00 Dr. Stone S1: 00:54:00-00:59:30 Kokoro Connect S1: 00:59:30-01:03:05 Sounds of Life S2: 01:03:05-01:05:00 Eureka 7 S1: 01:05:00-01:06:22 Tada Never Falls In Love S1: 01:06:22-01:07:24 Gabriel Dropout S1E3: 01:07:24-01:09:37 Yu Yu Hakusho E46: 01:09:37-01:11:56 Yona of the Dawn S1E4: 01:11:56-01:13:12 Mob Psycho 100 S1-S2: 01:13:12-01:27:36

Hayley is joined for this episode by Blake Smith and Jeb Card to discuss S1 & S2 of Hellier (produced by Planet Weird), and the shifting landscape of paranormal research. Blake Smith is a writer, researcher, and podcaster and hosts the MonsterTalk Podcast and the In ReSearch Of Podcast which he co-hosts with Jeb Card, an Archaeologist and author of 'Spooky Archaeology'. Episode notes: https://spooktator.co.uk/index.php/2020/03/28/exploring-hellier/

Westworld Season 1 Recap - Your “hosts” Kelly and Don take a look back at Season 1 (with an occasional mention of Season 2) as they prepare for Season 3 to kick off. (NOTE: Much like the interesting timelines on the show, the S1/S2 recaps take place before the S3 premiere, but got released after. Delos orders.) Host Kelly Guimont with Don Melton.

Your “hosts” Kelly and Don dig into Season Two and all the twists and turns as they look forward to the Season Three premiere. (NOTE: Much like the interesting timelines on the show, the S1/S2 recaps take place before the S3 premiere, but got released after. Delos orders.) Host Kelly Guimont with Don Melton.

Westworld Season 1 Recap - Your “hosts” Kelly and Don take a look back at Season 1 (with an occasional mention of Season 2) as they prepare for Season 3 to kick off. (NOTE: Much like the interesting timelines on the show, the S1/S2 recaps take place before the S3 premiere, but got released after. Delos orders.) Host Kelly Guimont with Don Melton.

Your “hosts” Kelly and Don dig into Season Two and all the twists and turns as they look forward to the Season Three premiere. (NOTE: Much like the interesting timelines on the show, the S1/S2 recaps take place before the S3 premiere, but got released after. Delos orders.) Host Jason Snell.

Your “hosts” Kelly and Don dig into Season Two and all the twists and turns as they look forward to the Season Three premiere. (NOTE: Much like the interesting timelines on the show, the S1/S2 recaps take place before the S3 premiere, but got released after. Delos orders.) Host Jason Snell.

Your “hosts” Kelly and Don take a look back at Season 1 (with an occasional mention of Season 2) as they prepare for Season 3 to kick off. (NOTE: Much like the interesting timelines on the show, the S1/S2 recaps take place before the S3 premiere, but got released after. Delos orders.) Host Kelly Guimont with Don Melton.

In this episode, we recap S1 & S2 before we jump into harnessing the power of Gratitude. We discuss why gratitude is so powerful and I share a guided meditation centered on moments of Gratitude that you can listen to daily as an addition to your practice. Listen, enjoy, and share with someone who needs a reminder to be grateful everyday

Inspired【女性images系列】 #01期#【This is my vagina！】 主播：Maggie&删删 BGM：Ezra Furman - Love You So Bad（也是Sex education的OST） 提到的书影音： 《sex education》(S1S2) 《sex and city（欲望都市）》 《退步集》陈丹青 《古怪的身体》[日] 鷲田清一 这是Inspired女性Images系列的第一期，我们用了【vagina】作为第一个想表达的意向。 不允许被提起的生理期，被削去的长发，被隐藏的痛苦，一个女性的成长似乎充满了省略号。 当生理期成为敏感词汇，我们的生活里到底还有多少省略号？ 这些看似平静的省略号里，有被忽视的痛苦，被误解的烦恼。 在这个系列中，我们想将目光更多的放在女性领域当中，去讨论那些普遍却尖锐、我们习以为常却不那么合理的【问题】。 希望所有的女孩，都能挺起胸膛，勇敢的抓住属于自己的选择权！ 如果你对这个话题感兴趣，或者有故事分享给我们，欢迎留言或者email至 inspired00@163.com，我们一直在！

Inspired【女性images系列】 #01期#【This is my vagina！】主播：Maggie&删删BGM：Ezra Furman - Love You So Bad（也是Sex education的OST）提到的书影音：《sex education》(S1S2)《sex and city（欲望都市）》《退步集》陈丹青《古怪的身体》[日] 鷲田清一这是Inspired女性Images系列的第一期，我们用了【vagina】作为第一个想表达的意向。不允许被提起的生理期，被削去的长发，被隐藏的痛苦，一个女性的成长似乎充满了省略号。当生理期成为敏感词汇，我们的生活里到底还有多少省略号？这些看似平静的省略号里，有被忽视的痛苦，被误解的烦恼。在这个系列中，我们想将目光更多的放在女性领域当中，去讨论那些普遍却尖锐、我们习以为常却不那么合理的【问题】。希望所有的女孩，都能挺起胸膛，勇敢的抓住属于自己的选择权！如果你对这个话题感兴趣，或者有故事分享给我们，欢迎留言或者email至 inspired00@163.com，我们一直在！

Ben and Tim as explore in depth ‘the power of ebay.’ This week’s newbie tip: ebay for the beginning trader. Ken Castille, talks about the S1 S2 and S3 of Achafalaya Lodge 563. Ken is a former Lodge Chief of Lodge 563 from 1971-1972. Our guest, Jason Spangler, former Lodge Chief of Santee Lodge and section Chief of the Dixie Fellowship talks about his site www.PatchBlanket.com and ebay how many collectors are treating ebay happenings as news. Are prices going up or down? What about the custom made private issues? What’s Jason’s favorite patch and which one does he wish he had?

Nenito day corillo terminamos el season 2 de Nenito hoy un recuento de los mejores momentos del S1 & S2 de Nenito con el JMOW, CHUY, EGEA, DUROSKY mas hablamos un poquito del season 3 y el tema pendiente cracks aquí las redes sociales y KITS nos vemos recuerden enviar su voice sexy al final de la descripción para saber de ustedes.. Season 3 donde lo vas a escuchar?   Instagram @gustavo.egea @chuy_113_ @goodmorales @nenitopr • twitter & snapchat @nenitocriolla • Podcast Gear https://kit.com/nenitocriolla/podcast-nenito-kit + https://kit.com/nenitocriolla/podcast-nenito-duo-kit • Summer Start Camera https://kit.com/nenitocriolla/start-low-budget --- Send in a voice message: https://anchor.fm/nenito/message Support this podcast: https://anchor.fm/nenito/support

BROPISODE: Round The Twist (S1-S2) by San Dimas School of Film

WARNING: THERE BE SPOILERS HERE. It’s finally here!!!!! After many previous mini chats within other episodes, we are, at last, sitting down to talk about Riverdale and our complicated feelings on this nuts-o show. Listen on to hear us discuss teen gangs, how much we love Cheryl Blossom, and some of the many, many theories … Continue reading Riverdale S1 + S2 (So Far) →

WARNING: THERE BE SPOILERS HERE. It’s finally here!!!!! After many previous mini chats within other episodes, we are, at last, sitting down to talk about Riverdale and our complicated feelings on this nuts-o show. Listen on to hear us discuss teen gangs, how much we love Cheryl Blossom, and some of the many, many theories … Continue reading Riverdale S1 + S2 (So Far) →

Sean (@seanzie_udk) and Scott (@ChasenScott) discuss all things Riverdale and hand out grades and awards for the popular TV show. Music credit: bensound.com.

S1 • S2

Paul Wang:         Welcome to the monthly podcast On The Beat for Circulation, Arrhythmia and Electrophysiology. I'm Dr. Paul Wang, editor-in-chief, with some of the key highlights from this month's issue. We'll also hear from Dr. Suraj Kapa, reporting on new research from the latest journals in the field.                                 In our first article, Elyar Ghafoori and associates examined the ability of late gadolinium enhancement MRI done immediately after ablation to predict edema and chronically even size. In a canine model, the authors created ventricular radiofrequency ablation lesions. All animals underwent MRI immediately after ablation. After one, two, four and eight weeks, edema and microvascular obstruction MVO, in enhanced volumes were identified in MRI. Immediately after contrast administration, the microvascular obstruction region was 3.2 times larger than the chronic lesion volume size in acute MRI. The authors found that microvascular obstruction region on acute late gadolinium enhancement images acquired 26 minutes after contrast administration most accurately predicts chronic lesion volume.                                 In the next article, Elad Anter and associates characterized the atrial substrate in patients with paroxysmal atrial fibrillation and obstructive sleep apnea. The authors examined 86 patients with paroxysmal atrial fibrillation, 43 with moderate obstructive sleep apnea and 43 without obstructive sleep apnea. The right atrial and left atrial voltage distribution conduction velocities in electrogram characteristics were examined. The authors found that patients with obstructive sleep apnea had lower atrial voltage amplitude, slower conduction velocities, and higher prevalence of electrogram fractionation. Most commonly, the left atrial septum was an area of atrial abnormality while at baseline the pulmonary veins with the most frequent triggers for atrial fibrillation in both groups after pulmonary vein isolation in patients with obstructive sleep apnea had an increased incidence of extrapulmonary vein triggers, 41.8% versus 11.6%, p=0.003. The one year arrhythmia-free survival are similar between patients with and without obstructive sleep apnea, 83.7% and 81.4%, respectively.                                 In comparison, control patients with paroxysmal atrial fibrillation and obstructive sleep apnea who underwent pulmonary vein isolation alone without ablation of extrapulmonary vein triggers had an increased risk of arrhythmia recurrence, 83.7% versus 64.0%, p=0.03, suggesting that ablation of these triggers resulted in improved arrhythmia-free survival. A randomized trial would be needed to prove this relationship.                                 In the next article, Iolanda Feola and associates demonstrated that optogenetics may be used to induce and locally target a rotor in atrial monolayers. The authors used neonatal rat atrial cardiomyocyte monolayers expressing a depolarizing light-gated ion channel, calcium-translocating channelrhodopsin. These monolayers were subjected to patterned illumination to induce the single, stable, and centralized rotor by optical S1-S2 cross-field stimulation. Next, the core region of these rotors was specifically and precisely targeted by light to induce local conduction blocks of circular or linear shapes. Conduction blocks crossing the core region, but not reaching an unexcitable boundary, did not lead to termination. Instead, electrical waves started to propagate along the circumference of block. If, however, core-spanning lines of block reached at least one unexcitable boundary, reentrant activity was consistently terminated by wave collision, suggesting that this may be a key mechanism for rotor elimination.                                 In our next study, Adam Barnett and associates used data from the outcomes registry for better informed treatment of atrial fibrillation ORBIT-AF to determine how frequently patients receive care that was concordant with 11 recommendations of the 2014 AHA, ACC, HRS A-fib guidelines pertaining to antithrombotic therapy rate control in anti-arrhythmic medications. The authors also analyzed the association between guideline concordant care and clinical outcomes at both the patient's level and center level. The authors study 9,570 patients with the median A 275, median CHA2DS2-VASc score of 4. A total of 62.5% or 5,5977 patients received care that was concordant with all guideline recommendations for which they were eligible. Rates of guideline concordant care was higher in patients treated with providers, with greater specialization in arrhythmias; 60.0%, 62.4%, 67.0% for primary care physicians, cardiologists and electrophysiologist, respectively; p less than 0.001. During a median of 30 months of follow up, patients treated with guideline concordant care had a higher risk of bleeding hospitalization; hazard ratio, 1.21. Similar risk of death, stroke, major bleeding can all cause hospitalization.                                 In our next article, Hui-Chen Han and associates conducted electronic search of PubMed and Embase for English scientific literature articles to characterize the clinical presentation, procedural characteristics, diagnostic investigations and treatment outcomes of all reported cases of atrioesophageal fistula. Out of 588 references, 120 cases of atrioesophageal fistula were identified. Clinical presentation occurred between 0 and 60 days postablation with a median of 21 days. The most common presentations were fever 73%, neurological 72%, gastrointestinal 41%, and cardiac 40% symptoms. Computed tomography of the chest was the commonest mode of diagnosis, 68% although six cases required repeat testing. Overall mortality was 55%. In conclusion, the authors reported that atrioesophageal fistula complicating atrial fibrillation is associated with a very high mortality 55% with significantly reduced mortality in patients undergoing surgical repair 33% compared to endoscopic treatment 65%, and conservative management 97%. Odds ratio adjusted 24.9; p less than 0.01 compared to surgery. Neurological symptoms adjusted odd ratio 16.0. In GI bleed, adjusted odds ratio 4.2, were the best predictors of mortality.                                 In the next article, Wei Ma and associates reported that the site origin of left posterior fascicular ventricular tachycardia may be predicted using 12-lead EC morphology in the HIS-ventricular or H-V interval. The authors studied 41 patients who underwent successful catheter ablation of left posterior fascicular ventricular tachycardia. The location of the site of origin was separated into proximal, middle, and distal groups with H-V being greater than zero milliseconds in the proximal group, H-V zero to minus 15 milliseconds in the middle group, and H-V less than negative 15 milliseconds in the distal group. The earliest presystolic potential ratio that is PP-QRS interval during VT divided by the H-V interval during sinus rhythm was statistically significantly different between the three groups, 0.59, 0.45 and 0.31, respectively. In addition, the QRS ratio in the proximal group 114 milliseconds was significant nearer compared to the middle group 128 milliseconds and the distal group 140 milliseconds. The QRS duration in the ratio R to S in leads V6 and lead-1 could predict a proximal or distal origin of left posterior fascicular ventricular tachycardia with high sensitivity and specificity.                                 In our next article, Niv Ad and associates examined the safety and success of on-pump minimally invasive stand-alone Cox-Maze 3/4 procedure via right mini-thoracotomy in 133 patients with nonparoxysmal atrial fibrillation five years after surgery. The mean follow-up was 65 months in a patient population with a mean age of 57.3 years, mean left atrial size of 4.9 centimeters, mean AF duration of 51 months and 78% with longstanding persistent atrial fibrillation. All procedures were performed with no conversion to mid-sternotomy. No renal failure, strokes or operative mortality in less than 30 days. They reported a TIA in one patient, re-operation for bleeding in two patients, and median length of stay in four days. At five years, 73% of patients were in sinus rhythm off anti-arrhythmic drugs following a single intervention.                                 In the next article, Richard Soto-Becerra and associates reported that unipolar endocardial electro-anatomic mapping may be used to identify scar epicardially in chagasic cardiomyopathy. In 19 sick patients, a total of 8,494 epicardial and 6,331 endocardial voltage signals in 314 epicardial and endocardial match pairs of points were analyzed. Basolateral left ventricular scar involvement was observed in 18 out of 19 patients. Bipolar epicardial and endocardial voltages within scar were low, 0.4 and 0.54 millivolts, respectively in confluent indicating a dense transmural scarring process. The endocardial unipolar voltage value with the newly proposed less than of equal to four-millivolt cutoff predicted the presence and extent of epicardial bipolar scar, p less than 0.001.                                 In our next article, Bing Yang and associates reported the results of the stable SR study, which is a multicenter clinical trial of 229 symptomatic nonparoxysmal atrial fibrillation patients random-eyed one-to-one to two ablation strategies. In the stable SR group following pulmonary vein isolation, cavotricuspid isthmus ablation in conversion to sinus rhythm left atrial high density mapping was performed. Areas of low voltage and complex electrogram were further homogenized and eliminated, respectively. Dechanneling was done if necessary. In the step-wise group, additional linear lesions and defragmentation were performed. The primary endpoint was freedom of documented atrial tachyarrhythmias lasting 30 seconds or more after a single ablation procedure without anti-arrhythmic medications at 18 months. At 18 months, success according to intention-to-treat analysis was similar in the two arms with 74.0 success in the stable SR group and 71.5% success in the step-wise group; p=0.3. However, shorter procedure time reduced fluoroscopic time after pulmonary vein isolation and shorter energy delivery time were observed in the stable SR group compared to the step-wise group.                                 In the final paper, Alan Sugrue and associates studied the performance of a morphological T-wave analysis program in defining breakthrough long QT syndrome arrhythmic risk beyond the QTc value. The author studied 246 genetically confirmed LQT1 patients and 161 LQT2 patients with a mean follow-up of 6.4 years. A total of 23 patients experienced more than one breakthrough cardiac arrhythmic event with 5 and 10-year event rates of 4% and 7%. Two independent predictors of future long Qt syndrome-associated cardiac events were identified from the surface ECG using a proprietary novel T-wave analysis program. The authors found that the most predictive features included the left slope of T-wave in V6, hazard ratio of 0.40, and T-wave center of gravity X-axis in lead-1, hazard ratio 1.9, C statistic of 0.77. When added to QTc, discrimination improved from 0.68 for QTc alone to 0.78. Genotype analysis showed weaker association between these T-wave variables in LQT1 triggered events while these features were stronger in patients with LQT2 and significantly outperformed the QTc interval.                                 That's it for this month, but keep listening. Suraj Kapa will be surveying all journals for the latest topics of interest in our field. Remember to download the podcast On the Beat. Take it away, Suraj. Suraj Kapa:          Thank you, Paul. This month, we will again focus on hard-hitting articles from across the electrophysiological literature. I am Suraj Kapa and we're particularly focusing on articles published in October 2017.                                 The first article we will focus on is within the realm of atrial fibrillation specifically related to anticoagulation. In Journal of the American Heart Association in Volume 6, Issue 10, Lin, et al. sought to develop a prediction model for time in therapeutic range in older adults taking vitamin K antagonists. As we know, time in therapeutic range is critical for management of patients on vitamin K antagonists. As poor time in therapeutic range either due to subtherapeutic or supratherapeutic INRs, can lead to increased bleeding or thromboembolic risk. While novel oral anticoagulants have improved care of patients requiring anticoagulation, many patients either due to cost or due to other factors are unable to take the novel oral anticoagulants and thus must be maintained on vitamin K antagonists. In this study, Lin, et al. Used well-over 2,500 patients to create training and validation sets and thereby create two models for estimating time in therapeutic range. Through this, they created a simple model term PROSPER consisting of seven variables including pneumonia, renal dysfunction, prior bleeding, hospital stay more than seven days, pain medication use, lack of access to structured anticoagulation services, and treatment with antibiotics.                                 Using this, they showed that they can predict time in therapeutic range greater than 70% as well as thromboembolic and bleeding outcomes better than other existing time in therapeutic range scoring systems, such as the same TT2R2 score. The reason these scores are important are both to help patients understand when they may be at risk for not maintaining a time in therapeutic range and to assist them in identification of the right anticoagulant methodology or strategy. Also, perhaps to prospectively consider if we can identify patients who may require more intensive monitoring or structured therapy strategies. However, one must also consider that for scores like this, utilization is always critical. In other words, continuous validation of the scoring system must be done in order to make sure it's applicable across populations and across different groups of people in different communities.                                 Next, within the realm of anticoagulation and atrial fibrillation, we'll review the article by Chang, et al. published in JAMA in Volume 318, Issue 13 entitled Association Between Use of Non-Vitamin K Oral Anticoagulants With and Without Concurrent Medications and Risk of Major Bleeding Non-Valvular Atrial Fibrillation. With any new drug that comes out, there's always the possibility of various medication interactions. The source of these medication interactions might be variable. They might include direct effects of other medications on systems by which the primary drug is metabolized. Also, might be due to synergistic effects of medications that might be unpredictable or effects on different aspects of systems the drugs are trying to treat. Thus oftentimes, larger population studies are required before one can appreciate drug interactions that might exist. This is particularly true with novel oral anticoagulant drugs. Part of the promise of the novel oral anticoagulants was that because of the extensive medication interactions associating vitamin K antagonists, the availability of the drug perhaps with fewer medication interactions resulting in alteration and bleeding or thromboembolic tendency will be very important.                                 In this important paper, Chang, et al. reviewed the effect of other medications on major bleeding events in patients on non-vitamin K oral anticoagulants such as dabigatran, apixaban, and rivaroxaban. Amongst over 91,000 patients, they noted that the concurrent use of amiodarone, fluconazole,  rifampin, and phenytoin compared with the novel oral anticoagulant alone was associated with a significant increase many times by odds ratio of 100 in risk of major bleeding. Several drugs including atorvastatin, digoxin, erythromycin or clarithromycin when used concurrently with NOACs interestingly were associated with the reduced risk of bleeding without elevating thromboembolic risk. The recent advent of NOACs in clinical use especially in patients who might be taking other medications always need to be considered in the context of how the other medications might affect the bleeding or thromboembolic risk. One of the key findings in this publication is the potential interaction with amiodarone and how concurrent use of amiodarone may increase the risk of major bleeding. Because of the general lack of tools to monitor the effects of NOACs on bleeding risk in patients, one needs to consider these population studies and whether or not there might be synergistic effects between medications going forward.                                 Unfortunately, we cannot adopt guidelines purely based on this data as to whether or not a dose adjustment should occur or whether or not the medication can be used at all. However, it does highlight the care that should be taken when using many of these drugs in conjunction with NOACs.                                 Finally within the realm of anticoagulation and atrial fibrillation, we'll review the article by Cannon, et al. in The New England Journal of Medicine entitled Dual Antithrombotic Therapy with the Dabigatran After PCI in Atrial Fibrillation. In this study, Cannon, et al. sought to systematically review the role of a warfarin strategy post-PCI versus dabigatran strategy post-PCI. They randomized patients to use of a combination of warfarin, aspirin, and a P2Y12 inhibitors such as clopidogrel post-PCI versus using dabigatran plus a P2Y12 inhibitor. They demonstrated that dual therapy approach with dabigatran resulted in significantly lower bleeding events than the triple antithrombotic/antiplatelet therapy group. There was no difference in adverse events including thromboembolism, unplanned revascularization or death between the groups. These findings were irrespective of whether patients were on 110 mg of dabigatran or 150 mg of dabigatran. These findings suggest that a dual therapy approach in the post-PCI setting with the NOACs as the dabigatran and the P2Y12 inhibitors such as clopidogrel lowers bleeding risk without increasing risk of major adverse events including thromboembolism or stent thrombosis after PCI.                                 However, it should be noted that one major criticisms of this trial is that the incremental bleeding risk conferred by aspirin could not be accounted for in the triple therapy cohort as aspirin was not used in the dual therapy cohorts. Thus, one cannot necessarily say whether the same finding would have been noted in a warfarin plus P2Y12 inhibitor versus dabigatran plus P2Y12 inhibitor especially given recent evidence suggesting no incremental benefit of aspirin particularly for thromboembolic risk associated with atrial fibrillation. However, the critical element of these findings is that a strategy excluding aspirin where dabigatran plus the P2Y12 inhibitor are used post-PCI might be actually safe.                                 Changing gears, we will next focus on an article within the realm of cardiac mapping and ablation in atrial fibrillation. This was published in the Journal of the American College of Cardiology in Volume 70, Issue 16 by Prabhu, et al. entitled Catheter Ablation Versus Medical Rate Control in Atrial Fibrillation and Systolic Dysfunction: The CAMERA-MRI Study. In this study, Prabhu, et al. studied in the multicenter randomized clinical trial the effect of catheter ablation for atrial fibrillation in the setting of left ventricular systolic dysfunction versus medical rate control. They looked at the change in ejection fraction over a follow-up of six months. A total of 68 patients were randomized in the study. They demonstrated an absolute improvement in EF by 18% in the ablation group versus 4% in the rate control group, with also a greater rate of EF normalization with ablation. In fact, over 50% of patients had EF normalization after ablation whereas only about 9% had a good medical rate control.                                 Furthermore, the improvements in EF correlated with the absence of late gadolinium enhancement on MRI and in the medical rate control group an average heart rate less than 90 beats per minute was achieved across the population randomized this approach. These findings are somewhat contrary to other studies that suggested that a rate versus a rhythm control approach were not really much different in patients with reduced left ventricular systolic function. These challenges are paradigm by suggesting that in fact successful restoration of normal rhythm in patients postablation can actually confer improvement in ejection fraction in some patients even when rate controlled. The success rates that should be noted in this study were similar to those published in most existing literature with about 56% of patients without further atrial fibrillation after a single ablation off medications and a success rate of 75% after a single ablation on medications. While the number of patients included are small and thus may be difficult to challenge the paradigm that was created, the rate versus rhythm control are equivalent in patients with reduced systolic function.                                 This finding should raise awareness that it is quite possible that there might actually be benefits in restoring normal rhythm by modern approaches in patients with reduced systolic function.                                 Moving on, still within the realm of atrial fibrillation, however, we'll next review the article by Aronsson, et al. in Europace Volume 19, Issue 10 entitled Designing an Optimal Screening Program for Unknown Atrial Fibrillation: A Cost-Effectiveness Analysis. More and more with an understanding that atrial fibrillation is essentially of epidemic proportions, but many patients tend to be asymptomatic and yet having an elevated stroke risk. People are focusing on how do we screen these populations in a manner that is both cost-effective as well as strategic. Aronsson, et al. tried to use computer simulation modeling to determine what the optimal age was to initiate screening for atrial fibrillation. They ran more than two billion different design screening programs that could be implemented at different age ranges and using data from published scientific literature. They tested these various screening programs. They demonstrated that the screening starting at the age of 75 was associated with the relatively low cost per gained quality adjusted life year. The overall cost at this level was 4,800 euros across the population for quality adjusted life year gained across that population.                                 The relevance of this publication while simulation model lies in highlighting the importance of considering what programs can we actually achieve in the modern day to better identify patients with atrial fibrillation who are not yet identified. Across the literature and in recent clinical meetings, there's a number of articles that are being published regarding the role of different strategies in identifying the asymptomatic, not yet diagnosed atrial fibrillation patients. This study presents an initial foray into systematizing programs that might be applied to recognition of these patients.                                 Along a similar course, we'll also review an article by Reiffel, et al. in JAMA Cardiology Volume 2, Issue 10 entitled Incidence of Previously Undiagnosed Atrial Fibrillation using Insertable Cardiac Monitors in a High-Risk Population: The REVEAL AF Study. In this study, Reiffel, et al. Reviewed the incidence of atrial fibrillation identified using implantable loop recorders in those with a high risk of stroke nearly a CHADS2 score of 3 or greater, but had not been previously diagnosed. It should be noted that while these patients have never been diagnosed with atrial fibrillation, 90% had nonspecific symptoms such as fatigue, dyspnea or palpitations, then theory could be attributed to atrial fibrillation. A total of 385 patients received monitors. They noted that by 30 months of monitoring, about 40% of patients have been identified as having atrial fibrillation that had not been diagnosed. If patients were only monitored for the first 30 days, however, the incident rate of atrial fibrillation in terms of new diagnosis was only 6%. In fact, the median time from device insertion to first episode of atrial fibrillation was almost four months at about 123 days.                                 In line with the previous discussed study by Arosson, et al., this study notes the importance of consideration of how we monitor patients at risk for stroke. The issue at hand is when we do screening, what is enough. The strategies used to identify atrial fibrillation of patients raised from advising on twice daily poll checks, which when done by the patient regularly might allow for identification of atrial fibrillation if they do it well to doing a single ECG, to doing a 24-hour Holter, to doing a 30-day monitor, to doing things like implantable loop recorders. However, this study by Reiffel, et al. suggests the a 30-day continuous monitor is truly insufficient if there is a high concern for atrial fibrillation. Thus with the goals to identify atrial fibrillation on high-risk patients or whether a significant clinical suspicion, one should always consider longer term monitoring by this study.                                 Finally, within the realm of atrial fibrillation, we'll review the article by Tilz, et al. published in Europace Volume 19, Issue 10 on left atrial appendage occluder implantation in Europe, indications anticoagulation post-implantation, results of the European Heart Rhythm Association survey. Currently, there's a high level of utilization of left atrial appendage occlusion for patients with atrial fibrillation who cannot otherwise be on a novel oral anticoagulants in Europe. Tilz, et al. performed a survey of providers performing these procedures. They found that about 52% of those centers performing left atrial appendage occlusion had electrophysiologist performing it as opposed to the remainder using interventional cardiologists. The most common indication for implantation was in those with high risk for stroke and with absolute contraindication to oral anticoagulation or history of bleeding. However, was most interesting from their study was that there was a very wide ranging practice in management after implantation in terms of use of antiplatelets for anticoagulants with 41% prescribing no therapy after implantation. There is even greater variability in therapies for patients who are found to have a thrombus after left atrial appendage occlusion ranging from no therapy to surgery.                                 These findings highlight the difficulty in managing practice patterns with novel technologist and in particular with left atrial appendage occlusion. The highly heterogeneous practice pattern found here suggests that large-scale population outcomes will be difficult to understand unless we understand the individual practice variation that is occurring such as considering what medications patients were prescribed on in the post-implant period or how patients were included in terms of whether or not they met the standard criteria. Furthermore, when a complication occurs such a thrombus septal left atrial appendage occlusion one might suspect that the implications of different strategies such as not doing any therapy all the way to routinely doing surgery tumor to clot should be considered.                                 Next, we will move on to the realm of ICDs, pacemakers, and CRT. First, reviewing the article by Pokorney, et al. published in Circulation in Volume 136, Issue 15 entitled Outcomes Associated With Extraction Versus Capping and Abandoning Pacing and Defibrillator Leads. In this study, Pokorney, et al. reviewed these two different approaches in abandoned leads amongst 6,859 patients. They found that extraction was associated with the lower risk of device infection, but there was no association between difference in mortality, need for future lead revision, or need for future extraction. This involved patients in the Medicare age group, but extraction patients of note, tended to be younger with fewer comorbidities, more often female and had a shorter lead dwell time. While they're statistically different, however, the actual number of years by which patients tended to be younger or to have a shorter lead dwell time was only a year.                                 The fact is that it is always hard to know what to do with an abandoned lead. Having more leads in the vascular system might lead to venous stenosis or might lead to patients having future problems when they need an extraction because of infection, or might make it harder to manipulate this in the vascular space. Thus whether extracting abandoned leads as opposed to just capping them and leaving there needs to be considered when taking any patient in for a lead revision or a lead addition for other reasons. These findings suggest that extraction confer similar mortality risk but lower long-term infection risk than capping them. However, it should be noted this is retrospective data set and given the extraction patients already were younger and had their leads for relatively shorter durations with your comorbidities, they might have reflected to healthier population anyway. However, these data are suggestive and highly the need for further study into whether a more aggressive approach with abandoned lead should be considered. Without randomized data, it will not be for certain.                                 Next, also within the realm of lead extraction, we'll review the article by Bongiorni, et al. published in the European Heart Journal in Volume 38, Issue 40 entitled The European Lead Extraction Controlled Study: A European Heart Rhythm Association Registry of Transvenous Lead Extraction Outcomes. This prospect of registry on lead extraction the largest to dates, Bongiorni, et al. reviewed safety and complications in addition to relationship to the type of center. They noted that the overall hospital major complication rate was 1.7% with mortality rate of 0.5% associated with lead extraction. The most common complication was actually pericardial synthesis, need for a chest tube or need for surgical repair. Overall, success rates for lead extraction in terms of complete removal of all lead components was 97%. However, it should be noted the overall complication rate and success rates were better in high-volume centers than low-volume centers. These findings are consistent with prior data published by [Desmott 35:22] and others, suggesting that more experience associates with better outcomes in lead extraction. However, these data represent the largest prospective registry on lead extraction and confirm the safety and efficacy of overall current practices.                                 These better data on modern lead extraction may help facilitate discussions with patients regarding actual outcomes and also decisions on whether or not extraction should be engaged in individual practices.                                 Next, we'll review the article by Aro, et al. in the realm of sudden death cardiac arrest entitled Electrical Risk Score Beyond Left Ventricular Ejection Fraction: Prediction of Sudden Cardiac Death in the Oregon Sudden Unexpected Death Study in the Atherosclerosis Risk and Communities Study, published in the European Heart Journal in Volume 38, Issue 40. In this study, Aro, et al. reviewed what features beyond ejection fraction could predict sudden death in community cohorts. They specifically focus on the electrocardiogram and demonstrated an electrocardiogram risk score based on the presence or absence of a number of features related to heart rate, left ventricular hypertrophy, QRS transition zone, QTc, and others. They found that amongst those patients with a left ventricular ejection fraction greater than 35%, the presence of four more of these ECG abnormalities confer an odd ratio of sudden death of 26.1. The importance of this article is highlighting how more complex considerations of clinical risk might help in further adjudication of sudden death in poorly characterized cohorts.                                 While most studies have concluded that addition of a variety of additional features such a T-wave alternans do not really confer incremental benefit beyond the ejection fraction in adjudicating sudden death risk and in helping decision making regarding ICD implantation. The fact is that more complex analyses that might exist in more nonlinear approaches or consider more advanced features, the ECG and combination, might confer some benefit in poorly characterized populations such as those with moderately reduced ejection fraction between 35 and 50. We know that while those with an ejection fraction less than 35% is a population have a higher risk within that population, the majority of patients who suddenly die do not have an EF less than 35%. Thus, identifying patients without an EF less than 35% who might be at risk is important. This study by Aro, et al. indicates one potential option to help discriminate patients who might not fit within normal categories for sudden death adjudication and did not fit neatly within the trials. However, prospect of evaluation of application of scoring systems either this one or others that may come in the future will be critical.                                 Changing realms yet again, we'll focus on cellular electrophysiology on an article by Kofron, et al. entitled Gq-Activated Fibroblasts Induce Cardiomyocyte Action Potential Prolongation and Automaticity in a Three-Dimensional Microtissue Environment, published in The American Journal of Physiology, Heart and Circulatory Physiology in Volume 313, Issue 4. In this publication, Kofron, et al. demonstrated that in this three-dimensional microtissue model, fibroblasts cause effects on the normal action potential in the surrounding environment leading to proarrhythmogenic automaticity. This model effectively demonstrated the activation of this fibroblast alone taken out of context by other triggers such as abnormalities of innervation, et cetera, could probably contribute to arrhythmogenicity into these hearts. It is well recognized in other studies that fibroblasts don't just cause proarrhythmic effects because of myocardial disarray. In fact, they can have paracrine effects on surrounding cells. This study by Kofron, et al. further highlights those potential effects. The presence of fibroblast amidst cardiomyocytes do not cause proarrhythmic tendency purely by shift in myocardial conduction direction, but also results from the effects of fibroblast once activated on these running cardiomyocytes action potentials of cells.                                 This study is suggesting specifically proarrhythmogenic arrhythmogenicity related to automaticity in those cardiomyocytes that are adjacent to fibroblast, highlights potential future targets for therapies and also highlights potential mechanisms by which arrhythmias might occurrence population.                                 Changing gears, we next look at genetic channelopathies in one article within the realm of Brugada syndrome and the second article within the realm of predicting QT interval. First, Hernandez-Ojeda, et al. published an article in The Journal of the American College of Cardiology Volume 70, Issue 16 entitled Patients With Brugada Syndrome and Implanted Cardioverter-Defibrillators: Long-Term Follow-Up. Amongst the 104 patients with long-term follow-up nearly greater than nine years on average, they noted a rate of appropriate therapy was very common especially in secondary prevention patients, however, was as much as 9% in otherwise asymptomatic patients. Appropriate ICD therapies, however, especially amongst asymptomatic patients were exclusively in those spontaneous type I Brugada ECG patterns and inducible ventricular arrhythmias, or those obviously the secondary prevention devices who have prior spontaneous ventricular arrhythmias. However, what is more interesting is that more than 20% of patients had some ICD-related complication. Furthermore, the overall incidence of inappropriate shocks was 8.7%, nearly the same rate as appropriate ICD therapies in the primary prevention population. These findings highlight that there is in fact a reasonable incidence of ventricular arrhythmic events needing ICD therapy even in asymptomatic Brugada patients.                                 However, I think the most striking finding is the high incidence of device-related complications of a follow-up, which highlights the need for considered selection and adequate device programming to avoid inappropriate ICD shocks and finally the need for regular follow-up of these relatively young patients receiving ICDs who might be more prone to complication with the long-term.                                 Changing gears, we'll next review an article by Rosenberg, et al. published in Circulation Genetics in Volume 10, Issue 5 entitled Validation of Polygenic Scores for QT Interval in Clinical Populations. Using more extensive genomic analyses, Rosenberg, et al. used populations and real-world cohorts including 2,915 individuals of European ancestry and 366 individuals of African ancestry. They demonstrated that clinical variables could account for about 9 to 10% of variation in QTc in Europeans and 12 to 18% in African ancestry individuals. However, interestingly, polygenic scores provided incremental explanation of a QTc variation but only in individuals of European ancestry. The reason we find this article interesting is the importance of understanding how much genetics can actually tell us and how what it can tell us might vary between difference, individuals of different backgrounds thus how we apply findings from one study to any other study. In the area of genetic testing, the Holy Grail is fully identifying overall risk scores to tell the patient what they may have without having to rely on clinical studies or other clinical variables. However, we do know that there is both an environmental component as well as the genetic components.                                 This study by Rosenberg highlights the importance of potentially considering both. The issue with the article, however, is the fact that while there was clear benefit of the polygenic score in patients of European ancestry, the African ancestry patients reflect the much smaller population almost one-eighth that of the patients included of European ancestry. Also, European versus African ancestry tend to be very broad-based terms. Whether or not there is greater polygenic variation within those of African ancestry as compared to those Europeans ancestry is relatively unclear. Thus while this study should be taken with grain of salt, it should also be considered in the context of providing a foray into seeing how polygenic scores could augment or understanding of how question intervals might vary in a population of people and might be identified immigrant patients.                                 Moving to the realm of ventricular arrhythmias, we'll first review the article by Siontis, et al. published in Heart Rhythm Volume 14, Issue 10 entitled Association of Preprocedural Cardiac Magnetic Resonance Imaging with Outcomes of Ventricular Tachycardia Ablation in Patients with Idiopathic Dilated Cardiomyopathy. In this study, Siontis, et al. tried to identify whether or not use of preprocedural MRI had any impact on overall procedural outcomes. They compared in a more modern practice where they are routinely obtaining cardiac MRI versus prior practice where they do not routinely obtain preprocedural MRI for ablation in patients with idiopathic dilated cardiomyopathy. They demonstrated that moderate use of preprocedural MRIs was associated with significantly greater procedural success mainly 63% in the modern approach versus 24% previously. The importance of the study why is in trying to understand what the actual value of preprocedural cardiac MRI is when patients are undergoing VT ablation particularly with non-ischemic cardiomyopathy. VT ablation outcomes are notoriously even harder to predict in non-ischemic cardiomyopathy cohorts than ischemic cardiomyopathy cohorts. Improved procedural experience, however, or different technologies may also alter long-term outcomes.                                 Thus, because the populations were not randomized and rather retrospective with a discrete change in practice that occurred temporally and just did not vary in terms of utilization over the course of periods of time when success rates might not have been affected just by incremental procedural success is difficult. However, these data suggest that future studies into the incremental role of MRI for VT ablation are needed to determine its utility.                                 Next, we'll review an article by Ho, et al. published in The Journal of Cardiovascular Electrophysiology in Volume 28, Issue 10 entitled ECG Variation During Ventricular Fibrillation Than Focal Sources Due to Wavebreak, Secondary Rotors, and Meander. Ho, et al. in this publication reviewed the role of rotors and focal sources in ventricular fibrillation. They attempted VF induction of 31 patients and use the combination of surface ECG and biventricular basket catheters to create face mask. They showed there's three differences between those with ventricular fibrillation that was mediate by rotors and those with ventricular fibrillation mediated by focal sources. Specifically those with rotor-based VF had greater voltage variation, which they demonstrated zero wavebreak, secondary rotor formation and rotor meander. One of the most critical findings of this study is the fact that a one-size-fits-all approach to consideration of the mechanism of fibrillation is likely unreasonable in most patients. They discriminate between rotor-based ventricular fibrillation and focal source-based ventricular fibrillation and highlighted there are discrete features that differentiate the two populations.                                 While this should be considered an initial foray into understanding these patients, clinical and computational size will be important into understand how we can discriminate mechanisms of complex arrhythmias between patients to help understand, which patients might most benefit from a specific ablation approach or therapeutic decision. This might also apply to atrial fibrillation where multiple mechanisms may coexist in the same patient for the pathogenesis of the arrhythmia.                                 Finally, we'll review an animal model by Patterson, et al. published in The Journal of Cardiovascular Electrophysiology in Volume 28, Issue 10 entitled Slow Conduction Through an Arc of Block: A Basis for Arrhythmia Formation Postmyocardial Infarction. In this study performed in the University of Oklahoma, Patterson, et al. reviewed a novel basis for arrhythmia formation after MI in an animal model. Amongst 108 anesthetized dogs, they demonstrated the delay potentials may decrement over shorter pacing cycle lengths leading to potential premature ventricular beat initiation after sufficient delay of the second potential. Thus, they demonstrated that there is a Wenckebach-like patterns of delayed activation specifically within this arc of conduction block associated with the region infarcted. These findings suggest that even across line of apparent conduction block there may be a potential for premature beat formation due to very slow conduction and thus a novel mechanism of PVC formation following myocardial infarction. Furthermore, it might highlight the mechanism by which to induce PVCs in this patient population                                 Just because there is conduction block the region of baseline mapping further provocative maneuvers to initiate or to discriminate where there might be very slow conduction might be critical to elicit arrhythmia in some patients.                                 Next, within the realm of syncope. We focus on article by Baron-Esquivias, et al. published in The Journal of American College of Cardiology Volume 70, Issue 14 entitled Dual-Chamber Pacing With Closed Loop Stimulation in Recurrent Reflex Vasovagal Syncope: The SPAIN Study. In this randomized double blind control study, Baron-Esquivias, et al. study the value of closed loop stimulation in the specific cohort of patients with cardio-inhibitory vasovagal syncope above 40 years of age. They demonstrated amongst 46 patients the closed loops stimulation was associated with the more than 50% reduction in syncopal spells in nearly three quarters of patients. However, it should be noted that up to 9% of patients continue to have syncope in your consistent frequency to prior. However, it should also be noted that sham cohort 46% of patients continue to have syncope while only a quarter were relieved. Syncope is one of the most challenging diagnosis to manage in electrophysiologic practice. This is both due to the heterogeneity of manifestation of syncope in terms of cause as well as the lack of many therapies that affect some of the autonomic features that mediate syncope. Largely, vasovagal syncope can be strategized into cardio-inhibitory and vasodilatory groups.                                 Generally, pacing will be more effective in theory for those more of a cardio-inhibitory than a vasodilatory component thus certainly patients can have both and thus that might be only partial attenuation of syncopal events by fixing the cardio-inhibitory by pacing but not the vasodilatory, which often requires medications. In this study, the use of closed loops stimulation seems to offer significant benefit in the specific population with cardio-inhibitory vasovagal syncope in age greater than 40 years. However, care should be taken not to necessarily apply these findings to patients not within this age group or within this diagnosis group.                                 Next within the realm of electrocardiography, we'll review an article by Yasin, et al. published in The Journal of Electrocardiology Volume 50, Issue 5 entitled Noninvasive Blood Potassium Measurement Using Signal-Processed, Single-Lead ECG Acquired from a Handheld Smartphone. Yasin, et al. reviewed the ability to determine changes in potassium level using the ECG. They demonstrated amongst 22 patients undergoing hemodialysis in whom estimation models could then be trained. The mean absolute error of ambulatory follow-up between the potassium estimated off of a single lead handheld smartphone-enabled ECG in the actual blood potassium was 0.38 milliequivalents per liter or a difference of 9% of the average potassium level. These findings suggest that in terms of clinical robustness a single lead smartphone-enabled handheld base ECG might be sufficient to estimate ambulatory potassium levels in patients who might be at high risk especially of hyperkalemia. The fact is that electrolytes and other abnormalities of a body homeostasis may be reflected in the ECG. However, whether the ECG may in turn be used to finally determine changes in characteristics such as electrolytes levels has not been very well described.                                 Previous work by the same group has suggested that the 12-lead ECG may be utilized to determine find potassium changes in patients undergoing hemodialysis. These findings while in small number of patients in this particular article highlights that ambulatory technologies such as the one they used here might in fact be utilized to discriminate potassium levels in patients who might be at risk of variations of potassium levels that can sometimes be life-threatening. Further validation will be required in larger populations, but this initial foray might create a paradigm for use of the ECG in ways beyond just looking for arrhythmias.                                 The final article we'll review is by Calzolari, et al. published in The Journal of American College of Cardiology, Clinical Electrophysiology in Volume 3, Issue 10 entitled In Vitro Validation of the Lesion Size Index to Predict Lesion Width and Depth After Irrigated Radiofrequency Ablation in a Porcine Model. In this paper published in the special of JACCEP focused on biophysics of ablation, Calzolari, et al. reviewed in vitro validation of lesion size indexing using radiofrequency ablation. Specifically, they reviewed the novel measure that incorporates not just contact force, power and time, but also impedance into predicting lesion quality. They noted that while lesion with in depth did not correlate with power or contact force alone, it did with either the lesion size indexing tool that they created and also with the force-time integral. However, the lesion size indexing where impedance was included was incrementally better than force-time integral. The truth is that improved prediction model lesion size inadequacy are critical during radiofrequency ablation.                                 Predicting lesion formation might help physicians know whether or not they have done adequate intervention at the time of application. They demonstrated incorporating impedance along with contact force, power, and time. The predictive value of their lesion indexing approach was quite good. However, further validation in association with an outcome is necessary to look at the incremental value. It also should be noted that this lesion size indexing tool did not necessarily predict steam pop formation, which is more often associated with power.                                 I appreciate everyone's attention to this key and hard-hitting articles that we have just focused on from this past month of cardiac electrophysiology across the literature. Thanks for listening. Now back to Paul. Paul Wang:         Thanks Suraj. You did a terrific job surveying all journals for the latest articles on topics of interest in our field. There's none an easier way to stay in touch with the latest advances. These summaries and a list of major articles in our field each month could be downloaded from Circulation, Arrhythmia, Electrophysiology website. We hope you'll find the journal to be the go-to place for everyone interested in the field. See you next month.    

  In our April journal club podcast Ben and Vic discuss the paper of the month – a classic debriefing article.   Jenny W. Rudolph, PhD, Robert Simon, EdD, Ronald L. Dufresne, MS, and Daniel B. Raemer, PhD There’s No Such Thing as “Nonjudgmental” Debriefing: A Theory and Method for Debriefing with Good Judgment. Simulation in Healthcare • Volume 1, Number 1, Spring 2006    We then reviewed some recent papers  The Simnovate series - all FREE for now Rajesh Aggarwal. Simnovate: simulation, innovation and education for better healthcare. BMJ Simulation and Technology Enhanced Learning Mar 2017, 3 (Suppl 1) S1-S2; DOI: 10.1136/bmjstel-2016-000184  Philip H Pucher, et al. Simulation research to enhance patient safety and outcomes: recommendations of the Simnovate Patient Safety Domain Group. BMJ Simulation and Technology Enhanced Learning Mar 2017, 3 (Suppl 1) S3-S7;   Wayne Choi, et al. Engagement and learning in simulation: recommendations of the Simnovate Engaged Learning Domain Group. BMJ Simulation and Technology Enhanced Learning Mar 2017, 3 (Suppl 1) S23-S32; DOI: 10.1136/bmjstel-2016-000177  Simulation Fellowship Programs: An International Survey of Program Directors.  Natal, Brenda MD, MPH; Szyld, Demian MD, EdM; et al. Academic Medicine April 4, 2017  An Innovative Approach: Using Simulation to Teach Primary Care Gynecologic Procedures. Hellier, Susan D. et al. Simulation in Healthcare: The Journal of the Society for Simulation in Healthcare January 9, 2017    And Ben introduced next month’s 2 papers – a complementary duo focused on Rapid Cycle Deliberate Practice.  Structuring feedback and debriefing to achieve mastery learning goals Eppich WJ1, Hunt EA, Duval-Arnould JM, Siddall VJ, Cheng A. Acad Med. 2015;90:00–00.  First published online doi: 10.1097/ACM.0000000000000934  Pediatric resident resuscitation skills improve after “Rapid Cycle Deliberate Practice” training Hunt EA, Duval-Arnould JM, Nelson-McMillan KL, Bradshaw JH, Diener-West M, Perretta JS, Shilkofski NA. Resuscitation. 2014 Jul;85(7):945-51. doi: 10.1016/j.resuscitation.2014.02.025. Epub 2014 Mar 4.    Looking forward to another great discussion   Vic 

In the 70th episode of ToonCast Beyond Joe Reed joins TFG1Mike for the first time here on Toon Beyond! This time we are here to talk about Voltron!!!! Yup the 1984 Voltron cartoon started it all! However the focus here is on the current series Legendary Defender We go over the plots of Seasons 1 and 2, the voice cast, the animation, and more. So get those dynatherms connected with us here on ToonCast Beyond as we form the head of Voltron!!!Geeks:Mike “TFG1" BlanchardJoe ReedSubscribe to us using iTunes or use any other podcatching client by using:http://feeds.feedburner.com/TooncastBeyond

In the 70th episode of ToonCast Beyond Joe Reed joins TFG1Mike for the first time here on Toon Beyond! This time we are here to talk about Voltron!!!! Yup the 1984 Voltron cartoon started it all! However the focus here is on the current series Legendary Defender We go over the plots of Seasons 1 and 2, the voice cast, the animation, and more. So get those dynatherms connected with us here on ToonCast Beyond as we form the head of Voltron!!!Geeks:Mike “TFG1" BlanchardJoe ReedSubscribe to us using iTunes or use any other podcatching client by using:http://feeds.feedburner.com/TooncastBeyond

"WE'RE BACK, BITCHES!" --Octavia Blake (and also us) Welcome back to Meta Station for the launch of our hiatus S1-S2 rewatch! We're kicking off with the pilot, about which you will be unsurprised to learn that we had a LOT to say. Join us for a trip down memory lane to talk about all your late lamented faves - Wells! Finn! Jake! Callie! Shumway! HA HA JUST KIDDING NOBODY LIKES SHUMWAY - along with Ark politics, class structure, character development, leadership parallels on the Ark and the ground, why Jaha saving Abby actually makes him terrible, the tonal shift from "CW teen drama" to "dark dystopian sci-fi", the origin story of both our ships, why Wells is the greatest and Finn is the worst, the glorious majestic wonderfulness of the Griffin women, and how despite S1 taking a few episodes to really find its footing, the pilot works remarkably well as a pilot. ALSO! Stay tuned at the end because we have A VERY! SPECIAL! ANNOUNCEMENT! ABOUT! A THING! Claire's really bad at keeping secrets so WE'RE REALLY EXCITED WE CAN TALK ABOUT THIS NOW Yay! We missed you! Hope you enjoy the episode and tune back in on 7/28 for our next podcast where we'll be discussing "Earth Skills" and "Earth Kills". Thanks for tuning in! ------------------------------------ 0:00 – HELLO AND WELCOME BACK AND SPOILER WARNING 0:02 – Clarke Griffin: Immediately Kickass Protagonist 0:09 – Rule Followers vs. Rule Breakers 0:12 – Um of Course Claire Can Quote the Kabby Arrest Scene Verbatim What the Hell Kind of Question is That Erin 0:22 – Soooooo, We Have to Talk About Finn 0:31 – Erin’s New Segment: “Why Is Jaha the Worst in This Episode?” 0:36 – Casual Reminder That S1 of This Show Is ALL About Class Conflict 0:39 – R.I.P. Wells Jaha, Literally Too Good for This World: Part I 0:45 – “Loopholes for the Privileged”: The Ark’s Fucked-Up Social Hierarchy 0:52 – R.I.P. Wells Jaha, Literally Too Good for This World: Part II 0:58 – ERIN SINGS! … And Then We Yell About Finn Some More 1:15 – The Secret Theme of This Show Is “Everyone Does Crazy Things For Love” 1:27 – We Haven’t Talked About Bellamy Yet and Erin’s Getting Twitchy 1:45 - GOD THIS CAST IS SO GOOD 1:50 - “She’s Got the Leslie Knope Problem”: The Truest Thing Anyone Has Ever Said About Clarke Griffin’s Leadership Skills 1:57 - Clarke/Kane and Bellamy/Abby Leadership Parallels 2:08 - A VERY SPECIAL ANNOUNCEMENT ABOUT A VERY COOL THING WITH SOME VERY SPECIAL GUESTS!

8 Years have gone by since the 1st Sports Card Show podcast. Glad to still be around the hobby and thanks to everyone that has tuned in over the years. Upper Deck's Digital/Physical Card Set - It's called Upper Deck Fusion and it only costs $0.79 per pack. - Trade cheaper Fusion for S1/S2 young guns?? Ben Simmons Signs Exclusive with Upper Deck - In a cock-block move Upper Deck signs the #1 overall pick to an exclusive deal. If the Lakers' Brandon Ingram and other players don't emerge, Panini's NBA products could really suffer slow year 1 sales. 2016 National Sports Collectors Convention First COMC eBay sales - Sales data seemed to be imported into your seller dashboard over in a 1 hour(ish) window. - Sold 3 cards so far. One card I wasn't the lowest price on the site, which is one advantage of the cross-listing feature is that sellers like me might not have to adjust to the lowest price. Kevin Durant to the Golden State Warriors NBA Summer League has been going in Orlando & Las Vegas. This is a really good time to get a look at NBA prospects that you can target to purchase during the 16/17 NBA Season. Last season I really like Myles Turner of the Indiana Pacers - and he had a really nice rookie season. Held for the Pelicans can pull his own shot. Brandon Ingram reminds me of a young Kevin Durant body-wise & footwork. His defense ability is better than Durant's. Zubac of the Lakers is a young center with very good footwork. Expect fans to bid his cards up in year one. Jared Goff's mom is buying his cards off eBay. Here's the thread on blowout about it.

027 - Molly Walker Detection System #3 - S1-S2 Hiatus Graphic Novels/Heroes Reborn Casting News    Lilith and Ricky discuss the Graphic Novels between season 1 and season 2. They include, Its Takes a Village, Betty, Golden Handshake, Heroism is Found in the Heart, and Blackout. They also discuss Heroes Reborn news. This includes Rya Kihlstedt Dylan Bruce, Nazeen Contractor (known as Farah Nazan), Jake Manley being cast, the three pictures released at upfronts, character names for Kiki Sukezane (Miko Otomo), and Zachary Levi (Luke Collins), Greg Grunberg, Sendhil Ramamurthy, Noah Gray Cabey, Greg Beeman returning, IGN’s breakdown of the Sizzle Reel (http://uk.ign.com/articles/2015/05/11/weve-seen-the-first-heroes-reborn-trailer), Tersyne’s breakdown of the sizzle reel (http://primatechfiles.tumblr.com/post/119144741699/tersyne-hr-promo-screencap-analysis-if-someone), small talks about the Canadian upfront trailer, and theory crafting.   Follow Primatech Files on their social media – just search “Primatech Files” on facebook, tumblr, youtube, twitter or clammr. You can also email primatechfiles@gmail.com or find them on their individual twitters @rickyjdiaz or @lilithhellfire   NB There may be spoilers in this review