Podcasts about neuroendocrine

In this video, I debunk all the recovery myths that keep you stuck. They might seem to work temporarily, but in the long run, they are a waste of your time. Whether you have long COVID, ME/CFS, Lyme, adrenal fatigue, chronic fatigue, fibromyalgia, or MCAS, this 20-minute video will save you years of time.Join our Q&A: https://releasecfs.com/contact/ Blog: https://releasecfs.com/developing-the-cfs-personality/Time Stamps: 00:59 The myth of the magic recovery moment 01:48 The myth of the baseline and pacing 03:40 The Cell Danger Response (CDR) by Dr. Robert Naviaux 04:22 Overcomplicating your recovery and healing journey 05:01 How to simplify your condition and understand different symptoms 07:15 The myth of the false danger response 07:44 The MindBody theory and lots of research 11:57 What is the best way to heal? 14:52 Myth - There is something wrong with your body (infections, immune system, genetics, mitochondria 16:42 The myth about Brain Retraining 19:04 Myth- Different things work for different people 19:46 The 4 steps to heal in the Release Program 21:13 Myth - Calming down the nervous system 21:36 Final Thoughts and tips.

This episode is part of a collaboration with the FlaNET Carcinoid Community, focusing on financial toxicity. We explore some of the major costs that can arise throughout the neuroendocrine cancer journey and share guidance on how to find helpful resources. NET specialists included in this episode Use our episode infographics to get a visual picture […] The post Managing the Financial Burden of Neuroendocrine Cancer appeared first on NETRF.

The episode features Dr. David Bartlett, a retired GP and neuroendocrine cancer patient, offering a dual perspective as both clinician and patient.Key Learnings from this episode.Patient Experience and Diagnostic ChallengesDr. Bartlett's symptoms began with severe, intermittent abdominal pain, starting in 2001, but he did not seek medical help for several years due to a combination of stoicism, not wanting to trouble others, and a belief in the commonality of benign causes. Over 15 years, he experienced repeated misdiagnoses, primarily being labeled as having irritable bowel syndrome (IBS) despite atypical features (severe pain, minimal bowel habit change, and no systemic symptoms). Multiple opinions and investigations (including ultrasounds and CT scans) failed to identify the underlying cause, with a key scan being misread by local radiologists. The correct diagnosis of a small bowel neuroendocrine tumour was only made after a tertiary centre re-examined previous scans, highlighting the importance of specialist review and persistence in unexplained cases.Clinical Red Flags and SymptomatologyDr. Bartlett's case underscores that neuroendocrine tumors can present with isolated, severe abdominal pain without classic red flags (vomiting, weight loss, significant bowel changes)[1]. He retrospectively identified subtle signs of carcinoid syndrome (flushing, one episode of profound diarrhoea, and skin changes), which are present in only about 10% of small bowel neuroendocrine tumour cases. The lack of awareness about neuroendocrine tumors, even among experienced clinicians, contributed to the diagnostic delay[1].Lessons for Primary Care and CliniciansThe story illustrates the risk of anchoring on common diagnoses (like IBS) and the need to reconsider the diagnosis when symptoms are severe, persistent, or atypical. It highlights the value of listening to the patient's narrative, especially when symptoms do not fit classic patterns, and the importance of considering rare conditions in the differential diagnosis. The episode emphasises the need for ongoing education about neuroendocrine tumours and the importance of keeping rare but serious conditions on the diagnostic radar in primary care.Management InsightsStandard treatment for small bowel neuroendocrine tumours often includes monthly somatostatin analog injections (e.g., lanreotide). Surgical intervention may be considered, but it carries specific risks such as carcinoid crisis, requiring specialised perioperative management. The decision for surgery is individualised, weighing potential symptomatic improvement against procedural risks.Systemic and Human FactorsDr. Bartlett's experience reflects how personal traits (stoicism, reluctance to seek help) and systemic issues (misinterpretation of scans, diagnostic inertia) can delay diagnosis. The narrative also demonstrates the importance of patient advocacy, persistence, and the value of second (or third) opinions, especially in complex or unresolved cases.Educational ValueThe episode serves as a reminder for clinicians to maintain a broad differential, revisit diagnoses when the clinical picture changes, and to be aware of their own cognitive biases. It also advocates for the inclusion of patient voices in medical education to better understand the lived experience and challenges of rare diseases like neuroendocrine cancer.Summary Table: Key LearningsThemeKey PointsDiagnostic Delay15 years from symptom onset t... Chapters (00:00:10) - Ingest(00:02:07) - David Bartlett on neuroendocrine cancer(00:05:32) - Irritable bowel syndrome, 15 years after first bout(00:12:09) - Carcinoid syndrome in small bowel neuroendocrine tumors(00:16:10) - Neuroendocrine tumour, surgery and recovery(00:20:43) - Somaostatin analogues for neuroendocrine cancer(00:25:43) - The role of the multidisciplinary team in bowel cancer care(00:28:21) - The battle with depression in your 50s(00:30:00) - General Practice and the Art of Medicine(00:33:13) - General Practice: The challenge of slowing down(00:35:35) - Neuroendocrine Cancer UK support group(00:39:28) - David's story of cancer(00:40:38) - David's Neuroendocrine Cancer Episode 1

In this special episode, medical oncologist and NET expert Dr. Diane Reidy-Lagunes engages in an open and honest discussion on sensitive topics, including sexual health, family planning and end-of-life discussions. She also answers common questions regarding cannabis use with cancer, as well as the relationship between sugar and cancer. Dr. Reidy shares information and insights from her decades of experience as well as from the award-winning “Cancer Straight Talk” podcast from Memorial Sloan Kettering Cancer Center (MSKCC) that she created and hosted, and she relates these topics to NET patients and their loved ones.TOP TEN QUESTIONS What is cancer? Is NET cancer?Should I follow a certain diet? Does sugar feed cancer? Can I exercise if I have metastatic neuroendocrine cancer?What does having neuroendocrine cancer mean for my romantic life? How does it affect dating?What does having neuroendocrine cancer mean for my sexual health?What does having neuroendocrine cancer mean for fertility and family planning? Can I have children?How do I talk to my kids about cancer?How will I know when it's time for end-of-life discussions?Should I consider cannabis?What advice do you have about improving communication with my doctor?For more information, visit LACNETS.org.

What is Carcinoid Heart Disease (CHD)? Which NET patients develop CHD?  Retired cardiologist and carcinoid heart disease specialist Dr. Jerome Zacks provides an overview of CHD and describes the appropriate screening, diagnosis, and treatment. MEET DR. JEROME ZACKSDr. Jerome Zacks is a Cardiologist/Carcinoid Heart Disease Specialist; retired since December of 2021; but remain active as Associate Clinical Professor of Medicine at the Icahn Medical School at Mount Sinai in New York City and founding member of the Center for Carcinoid and Neuroendocrine Tumors at the Icahn Medical School at Mount Sinai; founder of the Carcinoid Heart Center; formerly on the Medical Advisory Board of the Carcinoid Cancer Foundation;  currently head the Electrocardiography course for the 4th Year Medical Student elective at the Mt. Sinai Medical Center which has resulted in an international reputation among students seeking Cardiology training in the United States.  He has expertise in matters of health care Insurance Carriers' theft of funds from the Medicare program, has studied patterns of abuse in the Medicaid program and has extensive knowledge of pharmaceutical company abusive practices. Dr. Zacks continues to devote time to the care of patients with Carcinoid Heart Disease. He has served as a member of the Guidelines Committees of the European Neuroendocrine Tumor Society (ENETS) and of the North American Neuroendocrine Tumor Society (NANETS).   He developed a new approach to compression stockings for patients with leg edema; he was granted a patent for this innovation.  He has authored two national petitions urging Congress to mandate that any health care professional who uses one's license, in making decisions which influence a patient's care, be held to the SAME STANDARD OF CARE as the patient's treating professional. (These two petitions were blocked by Senator Cory Booker.)  In his role as patients' physician, he has attempted to remove barriers of communication.  His business card includes his personal mobile phone number as well as his email address and website information; He encourages patients to phone for immediate answers to urgent matters.  Along with his wife, Yelena - an RN- they have devoted their professional lives to patients with heart disease from rare Neuroendocrine tumors. They have mentored 5 children, and are now learning from them and their 6 grandchildren have provided the real fuel and excitement for their lives.For more information, visit https://www.ncf.net/podcast/43For more information, visit LACNETS.org.

Artificial intelligence (AI) has become a hot topic, making its way into everyday conversations and industries worldwide. While AI technologies have been around for years, recent advancements are accelerating their impact—especially in healthcare. From improving cancer research to enhancing diagnosis and treatment, AI is reshaping the future of medicine. In this episode of NETWise, we […] The post NETWise Episode 43: How Could AI Change Neuroendocrine Cancer? appeared first on NETRF.

Happiness is something that can be difficult to find in life, no matter what. Having an uncommon cancer can make it infinitely harder. The post NETWise Episode 42: Finding Happiness While Living with Neuroendocrine Cancer appeared first on NETRF.

Sol Wertkin is a former rock climber, cancer survivor, nurse, and avid mountain biker. We talked about new routing in the PNW, the “Golden Era” of Leavenworth climbing, the passing of Johnny Goicoechea, Sol's cancer diagnosis in 2020, the long and difficult road to recovery, how e-biking saved his life, sailing, why life feels richer now that he doesn't climb, and nuggets to help your own health journey.Feel free to message Sol on Instagram if you have any questions about cancer diagnosis or long covid. AG1:drinkAG1.com/NUGGETUse this link to get a free year's supply of vitamin D + 5 travel packs.Arc'teryx:Women's climbing clothingMen's climbing clothingCheck out the Psiphon and Serratus Alpine Kits launching January 15th.Rúngne:rungne.info/nugget

From the elusive neuroendocrine tumours like Rathke's Cleft Cysts and pituitary gland tumours to the broader impacts these conditions have on daily life, we explore it all. Join us as we navigate through the complexities of the body's inner workings, discuss the latest medical research, and hear firsthand accounts from those on the front lines of their own medical journeys. Whether you're a medical professional, a patient, or simply curious about the oddities of human biology, The Mutation Station offers insights and inspiration for everyone. Tune in to discover more about the mysteries of the human body and the resilience of the human spirit.

This special podcast highlights the papers chosen to be part of the #FGCup, the annual Frontline Gastroenterology competition to choose the readers favourite review paper in 2024. Dr Giovanna McGinty, a Trainee Associate Editor for FG and Gastroenterology Registrar at North Bristol Trust interviews (and contributes to the discussion) Dr Philip Smith, Editor in Chief of FG and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK, Dr Aditi Kumar, Deputy Editor for FG and Consultant Gastroenterologist at Royal Wolverhampton NHS Trust, Wolverhampton, UK and Dr Oliver Tavabie Deputy Editor for FG and Consultant Hepatologist at Leeds Hospitals NHS Trust, Leeds, UK.   They discuss the following papers: Improving management of eosinophilic oesophagitis in adults in the UK: proposal for an integrated care pathway British Society of Gastroenterology Endoscopic Retrograde Cholangiopancreatography (ERCP) Quality Improvement Programme: minimum service standards and good practice statements   From O'Shaughnessy to opportunity: innovating Hepatology Trials in the UK  Chronic abdominal pain in inflammatory bowel disease: a practical guide Colonic stents: who, where, when Investigation of abnormal liver blood tests in patients with inflammatory bowel disease Recent advances in the diagnosis and management of amoebiasis  Neuroendocrine tumours found at endoscopy: diagnosis and staging We hope you enjoy the #FGPodcast and join the #FGCup on X starting 6th January 2025. Please follow @‌FrontGastro_BMJ  

ABOUT THIS EPISODEWhat is radiation oncology, and how is it used for neuroendocrine cancer? UCSF radiation oncologists Dr. Will Chen and Dr. Alexandra Hotca-Cho describe external radiation therapy (SBRT) and how, when, and where it may be used for select patients with neuroendocrine cancers. They address common concerns about the planning process, safety concerns, and treatment sequencing.TOP TEN QUESTIONS ABOUT EXTERNAL RADIATION THERAPY FOR NEUROENDOCRINE CANCERS:1. What is radiation oncology? How does it work? How is it different from other types of radiation?2. What are the types of radiation therapies used for neuroendocrine cancer? 3. Which neuroendocrine cancers are they used for, and when are they used? How do you decide who is a good candidate and if it will be effective?Where in the body can SBRT be used? (bone, liver, pancreas, rectal?) Where can it not be used in the body, and when is SBRT NOT used?Is there a number or size limit of the tumor(s)?4. For Bone: How do NETs affect the bones? Are they “on” or “in” the bone, and does the tumor tend to weaken it?If given to the bone, does SBRT weaken the bone? What are the chances of fracture with radiation to the bone? Does it matter which area of the bone/body is treated? What other factors influence fracture risk? (age, dose, number of treatments)? Should patients have a bone density scan before SBRT?If bone lesions are causing pain, how soon after treatment might a patient expect to have pain alleviated?How common is increased pain after treatment to the bone? What causes that?5. Safety: How much radiation is given with these procedures? Is there a concern about radiation safety following the procedures? (Do patients need to avoid others in the hours or days after the treatment?)Is there a lifetime limit to the amount of radiation one can receive, especially considering surveillance CT & PET scans?How often can these procedures be repeated? Does it damage other tissues or organs? How common are secondary cancers? What types and how treatable are they?Is there a risk with fertility?What other risks are there?6. How do these therapies compare to PRRT or radioembolization in terms of safety? If someone has had PRRT or radioembolization, can they also receive radiation therapy to the liver or bones? Is there increased risks if someone has had PRRT, radioembolization or CAPTEM or alkylating agents? 7. Is there an optimal sequence for treatments? 8. What is SBRT like for patients? What is the planning and preparation process? How do you determine how many treatments and what dose to give?9. What does the patient experience during and after the procedure? Does it hurt? What are the side effects? How much time do I need to take off of work? 10. How effective is SBRT in terms of managing symptoms? How effective is SBRT in controlling or destroying the tumor?  How do you know if the treatment “worked”?Bonus: What is the future of radiation therapy in neuroendocrine cancer treatment?For more information, visit LACNETS.org.

My guests today are Laney and Bridgette Casey. Last year I interviewed their parents, Matt and Celeste. Over three years ago Matt was diagnosed with an extremely rare illness called Neuroendocrine cancer. It almost took his life and so often so much of the attention, although well deserved, goes to the person suffering. Often times the family can sometimes get overlooked even as they are suffering along side the sick or injured one. This is Matt's story through THEIR eyes. The eyes of the children. Have your tissues handy. Listen to Matt and Celeste's original story here https://podcasts.apple.com/us/podcast/parrish-the-thought/id1348128086?i=1000636743479 #NeuroendocrineCancer #CancerSucks #FamilyFirst #NetCancer #ZebraStrong #CancerCard  #CaseyFamily

Neuroendocrine tumors have a multitude of different names, including carcinoid disease, carcinoid syndrome neuroendocrine tumor, and neuroendocrine neoplasia. Join Chris Curry as he learns about these 'zebra' tumors, and why they can be so difficult to diagnose .

In this episode, we discuss the clinical and diagnostic markers when identifying a rare sub type of NSCLC, large-cell neuroendocrine carcinomas (LC-NEC), and provide insights into the management of these patients and future treatment developments. Associate Professor Rachel Wong, Deputy Director Oncology Eastern Health and Medical Oncologist at Epworth East in Melbourne is joined by Dr Patrick Hosking, Senior Histopathologist at Eastern Health Pathology; Dr Mal Itchins, Thoracic Medical Oncologist at Royal North Shore Hospital and Chris O'Brien LifeHouse in Sydney and Dr Sagun Parakh, Medical Oncologist at the Austin Hospital, Lung Cancer Lead. https://www.omico.com.au/our-programs/cancer-screening-program-casp/

Simron Singh, MD, MPH - Addressing the Challenges of Treating Highly Proliferative Neuroendocrine Tumours: Review of the Latest Evidence

Simron Singh, MD, MPH - Addressing the Challenges of Treating Highly Proliferative Neuroendocrine Tumours: Review of the Latest Evidence

After experiencing gastrointestinal issues in 2022, it took a total of four visits to ERs and an urgent care before a CT scan revealed Sarah Bennett had a mass in her duodenum, near her pancreas.  The mass later led to a diagnosis of a rare cancer, neuroendocrine.  She did not have to undergo a Whipple procedure, but did have to take an oral form of chemotherapy.  That preceded a successful surgical removal of the mass.  Sarah achieved survivorship and said her health is very close to what it was before her diagnosis.

What is supportive care or supportive oncology? What is cancer-related distress? How might NET patients benefit from supportive care? Yale oncologist Dr. Maryam Lustberg suggests strategies to manage cancer-related fatigue, diarrhea, nausea, mouth sores, peripheral neuropathy, distress, anxiety, and anxiety. She also addresses considerations for fertility and sexual health.MEET DR. MARYAM LUSTBERGDr. Maryam Lustberg is an American breast oncologist. She is the Director of The Breast Center at Smilow Cancer Hospital and Chief ofBreast Medical Oncology at Yale Cancer Center. Dr. Lustberg previously served as the Medical Director of Cancer Supportive Care Services atOhio State's Comprehensive Cancer Center. She is the Immediate Past President of the Multinational Association of Supportive Care in Cancer. She is also an Associate Editor for the Journal of Cancer Survivorship.TOP TEN QUESTIONS ABOUT SUPPORTIVE CARE: What is supportive care in cancer (or supportive oncology)? What is survivorship? How do these concepts apply to the NET community?What is the 1st step for patients to get supportive care?What are the most common treated-related adverse events or side effects? What are risk factors for them? (Will all patients experience all potential side effects?)What causes cancer-related fatigue (CRF)? What are some strategies to manage cancer-related fatigue?What are some strategies to manage diarrhea?What are some strategies to manage nausea?What are some strategies to manage mouth sores?What is peripheral neuropathy? When do patients experience it and what can be done to prevent it?What should patients understand about sexual health and fertility?How can psychosocial needs such as distress, anxiety, and depression be addressed and supported?For more information, please visit https://www.lacnets.org/podcast/37. For more information, visit LACNETS.org.

Send us a Text Message.SummaryIn this episode of the Next Level Human Podcast, Dr. Teta interviews Megan Lyons, a nutrition consultant, about the neuroendocrine-immune system and its impact on overall health. They discuss the effects of stress, exercise, and nutrition on the body, as well as the symptoms and signs of neuroendocrine dysfunction. Megan shares her personal journey of overcoming adrenal hormonal dysfunction and how it led her to focus on real nutrition. They also explore the role of the hypothalamus in regulating the endocrine system and the importance of addressing the root causes of dysfunction. In this conversation, Megan Lyons and Jade Teta discuss the role of testing in functional medicine and the complexity of interpreting test results. They also explore the importance of gut health and the impact of childhood development on the nervous system. They touch on the connection between thoughts, feelings, and the neuroendocrine-immune system and the potential for mind-body practices to improve health outcomes. Megan shares her personal experience with trauma and its impact on her nervous system, highlighting the need for a holistic approach to healing.Keywordsneuroendocrine-immune system, stress, exercise, nutrition, adrenal hormonal dysfunction, hypothalamus, root causes, functional medicine, testing, gut health, nervous system, childhood development, trauma, neuroendocrine-immune system, mind-body practicesChapters00:00- Introduction and Overview05:41- Personal Journey: Overcoming Adrenal Hormonal Dysfunction08:28- The Impact of Stress, Exercise, and Nutrition13:30- The Role of the Hypothalamus in Neuroendocrine Regulation16:45- Recognizing Symptoms of Neuroendocrine Dysfunction19:07- Addressing Root Causes for Restoring Balance24:08- The Complexities of Testing in Functional Medicine25:56- The Importance of Gut Health in Overall Well-being33:46- The Connection Between Thoughts, Feelings, and Health45:28- Taking a Holistic Approach to Healing Connect with Next Level HumanWebsite: www.nextlevelhuman.comsupport@nextlevelhuman.comConnect with Dr. Jade TetaWebsite: www.jadeteta.comInstagram: @jadeteta

#192 In this episode of 'Chemistry for Your Life,' hosts Melissa and Jam introduce special guest Claire Caballero, a pharmacology and neuroscience PhD student, to discuss how antidepressants work. Claire explains the role of neurotransmitters like serotonin, dopamine, and GABA in mental health, the mechanisms of various antidepressants such as SSRIs, tricyclic antidepressants, and monoamine oxidase inhibitors, and touches on the effects and side effects of drugs like Wellbutrin. The episode provides an insightful look at the chemistry and neuroscience behind how these medications help manage depression and anxiety. 00:00 Introduction and Special Guest Announcement 00:52 Meet Claire: Our Expert in Pharmacology and Neuroscience 01:32 Understanding Pharmacology and Neurotransmission 05:16 The Role of Neurotransmitters in Anxiety and Depression 14:16 Deep Dive into Neurotransmitters: GABA, Dopamine, and Serotonin 17:10 Exploring the Mechanisms of Depression and Anxiety 22:21 Ready to Learn About Antidepressant Drugs? 33:20 Understanding SSRIs and Their Uses 34:14 How SSRIs Work in the Brain 36:23 Challenges and Side Effects of SSRIs 43:08 Exploring Tricyclic Antidepressants 48:35 Monoamine Oxidase Inhibitors: The First Antidepressants 54:59 Benzodiazepines: Uses and Risks 01:00:01 Other Notable Drugs: Bupropion and Beta Blockers 01:05:07 Conclusion and Final Thoughts   References from this episode: https://www.ncbi.nlm.nih.gov/books/NBK554406/ https://www.ncbi.nlm.nih.gov/books/NBK557791/ https://www.ncbi.nlm.nih.gov/books/NBK539848/ https://www.ncbi.nlm.nih.gov/books/NBK470159/#:~:text=Benzodiazepines%20are%20effective%20for%20sedation,potential%20to%20develop%20physical%20dependence. https://www.nami.org/about-mental-illness/mental-health-conditions/anxiety-disorders/#:~:text=Anxiety%20disorders%20are%20the%20most,develop%20symptoms%20before%20age%2021. https://mhanational.org/conditions/depression#:~:text=Major%20depression%20is%20one%20of,are%20affected%20by%20major%20depression. https://www.cdc.gov/nchs/products/databriefs/db377.htm https://www.ncbi.nlm.nih.gov/books/NBK470212/ https://www.jneurosci.org/content/28/28/7040 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303399/ https://www.ncbi.nlm.nih.gov/books/NBK551683/#:~:text=Anxiety%20disorders%20such%20as%20panic,with%20decreased%20levels%20of%20GABA. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684250/#:~:text=Neuroendocrine%20and%20Neurotransmitter%20Pathways&text=Well%2Ddocumented%20anxiolytic%20and%20antidepressant,of%20mood%20and%20anxiety%20disorders. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950973/#:~:text=The%20monoamine%2Ddeficiency%20theory%20posits,in%20the%20central%20nervous%20system. https://www.health.harvard.edu/depression/depression-chemicals-and-communication https://www.ncbi.nlm.nih.gov/books/NBK539894/ https://www.sciencedirect.com/science/article/pii/S1476179306700246?via%3Dihub https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610616/ We want to give a special thanks to Bri McAllister for illustrating molecules for some episodes! Please go check out Bri's art, follow and support her at entr0pic.artstation.com and @McAllisterBri on twitter!   Thanks to our monthly supporters Scott B Jessie Reder Ciara Linville J0HNTR0Y Jeannette Napoleon Cullyn R Erica Bee Elizabeth P Sarah Moar Rachel Reina Letila Katrina Barnum-Huckins Suzanne Phillips Venus Rebholz Lyn Stubblefield Jacob Taber Brian Kimball Emerson Woodhall Kristina Gotfredsen Timothy Parker Steven Boyles Chris Skupien Chelsea B Bri McAllister Avishai Barnoy Hunter Reardon ★ Support this podcast on Patreon ★ ★ Buy Podcast Merch and Apparel ★ Check out our website at chemforyourlife.com Watch our episodes on YouTube Find us on Instagram, Twitter, and Facebook @ChemForYourLife

Neuroendocrine neoplasms (NENs) can arise in many locations throughout the body; they can grow rapidly; and they can occur under unique circumstances. In this episode of NETWise, we talk through some of the more uncommon locations – and situations – where neuroendocrine neoplasms arise. This episode is devoted to some of those more uncommon situations. […] The post NETWise Episode 37: Uncommon Neuroendocrine Neoplasms (NENs) appeared first on NETRF.

Have you ever wondered why weight management seems like an uphill battle? In this episode, I dive deep into the topic of weight management and the role of the neuroendocrine system. Discover how our hormones play a crucial role in weight regulation and why traditional weight loss approaches often fall short.   Join me as I discuss the impact of modern lifestyle on our hormones, the rise of obesity, and the pharmaceutical arms race in the quest for weight loss solutions. Learn about medications like ozempic and semaglutide and their effects on weight loss, alongside the importance of holistic approaches to address weight loss resistance.   If you're ready to unlock the secrets of sustainable weight management, understand the influence of processed foods on our endocrine system, and gain practical tips for achieving a healthy weight, this episode is a must-listen. Tune in now for valuable insights and strategies to conquer weight challenges in today's world.   And hey, speaking of unlocking secrets, don't forget to grab your FREE E-book, "A Woman's Guide to Kick-Ass Sleep." If you're over 40 and struggling with sleep, this E-book is tailored just for you. Visit https://bit.ly/4cblYcT to download your copy and embrace rejuvenating sleep nights starting tonight. Key Takeaways: [00:02:10] Struggling with weight loss efforts. [00:06:03] Neuroendocrine system and weight management. [00:10:01] Incretin hormones affecting food intake. [00:14:18] Lifestyle drugs and weight regain. [00:16:27] Impact of processed foods on health. [00:21:39] Endocrine disruption in daily products. [00:25:30] Whole foods focused. [00:29:16] Root cause of weight issues. Memorable Quotes: "You have a recipe for weight loss resistance that had nothing to do with your ability to control what you can eat and to control how much you exercise. Because again, it's not a simple bank account of calories in calories out. These hormones will supersede what your body is up to." – Betty Murray   "The weight is not the problem. It is a symptom of the problem. And that's the ultimate root cause answer that you need to understand." – Betty Murray Links Mentioned: FREE E-Book: https://bit.ly/4cblYcT   Connect with Betty Murray: Living Well Dallas Website: https://www.livingwelldallas.com/ Hormone Reset Website: https://hormonereset.net/ Betty Murray Website: https://www.bettymurray.com/ Facebook: https://www.facebook.com/BettyAMurrayCN/ Instagram: https://www.instagram.com/bettymurray_phd/  

Menstruation, pregnancy, birth, breastfeeding, motherhood, menopause… let's do this.In today's episode Jessica and Madeleine demystify the neuroendocrine system, and explain the interconnectedness of a woman's hormones and her nervous system throughout the various stages of her life.Weaving neuroscience research together with our own personal experiences, the conversation delves into the female menstrual cycle and its influence on the brain and nervous system. We also discuss the hormonal changes that take place during pregnancy and breastfeeding, as well as the social factors that can make the early months of parenthood so challenging, especially when returning to work.We explore many facets of childbirth including the importance of birth education, the experience of pain, the different states of the nervous system at play, spiritual perspectives, and the importance of the mother-baby dyad.Until recently there's been very little research into the brain changes that occur during menopause. We discuss the emerging research and some methods to better understand, validate and support women's experiences during this important rite of passage. Takeaways•The female brain is dynamic, and there is a need for a shift in perspective on women's health and well-being, recognizing the interconnectedness of the neuroendocrine system•The female menstrual cycle has a significant impact on the female nervous system, with fluctuating hormones influencing brain function and behavior.•Returning to work after maternity leave can be challenging for women, as hormonal changes and fatigue can affect cognitive function and memory.•During pregnancy and birth, the body undergoes profound hormonal changes that support the bonding process between mother and baby. Touch and connection are crucial for babies' healthy development, particularly in the areas of attachment and regulation.•The social factors impacting parenting have changed, with many women lacking the support of extended family and facing the challenges of balancing work and parenting.•Postpartum hormonal changes can both have a significant impact on women's well-being, and it is important to recognize and support women during this time.•Menopause is a significant transition that affects the neuroendocrine system, and it is important to understand and support women during this phase of life.•The biopsychosocial model of health provides a framework for understanding the biological, psychological, and social factors that influence women's health.•The conversation around women's health is evolving, and there is a growing recognition of the importance of addressing the unique needs and challenges faced by women.If you'd like to learn more about cultivating interoceptive accuracy to support yourself through times of change and transition, head to nervoussystemschool.com/female to access your free worksheet.If you enjoy our work, we'd love it if you could take a minute to follow us wherever you get your podcasts, and leave a rating and review. This helps to spread the word about the power of healing via neuroplasticity!Disclaimer

When and how often do NETs spread to the bones or brain? How are they found? What is the treatment? Dr. Robert Ramirez of Vanderbilt University addresses concerns surrounding bone metastases (or “mets”) as well as rare brain metastases.MEET DR. ROBERT RAMIREZ, DO, FACP Dr. Robert Ramirez is a medical oncologist specializing in the treatment of thoracic and neuroendocrine malignancies and an Associate Professor of Medicine at Vanderbilt University Medical Center in Nashville, TN.  He earned his medical degree from the University of Medicine and Dentistry of New Jersey School of Osteopathic Medicine. He completed an internal medicine residency at Cooper University Hospital in Camden, New Jersey. He then completed a hematology and medical oncology fellowship at the University of Tennessee Health Sciences Center in Memphis, Tennessee and served as chief fellow. He is a Fellow of the American College of Physicians, and a member of American Society of Clinical Oncology, the International Association for the Study of Lung Cancer (IASLC), and the North American Neuroendocrine Tumor Society (NANETS).  He serves on the Board of Directors for NANETS as well as the Scientific Review and Research Committee.His clinical and research interests include neuroendocrine tumors (NETs) and lung cancer.  He has a specific interest in NETs of the lung ranging from diffuse idiopathic pulmonary neuroendocrine tumor cell hyperplasia (DIPNECH) and carcinoid tumors to small cell lung cancer and other high-grade neuroendocrine carcinomas. He is active in clinical trial design including investigator-initiated trials. He enjoys teaching residents and fellows and has multiple publications and given many lectures for the scientific community on the topics of NETs and lung cancers.TOP TEN QUESTIONSBone mets:1. When and how often do NETs spread to the bones? 2. Where in the bones are tumors? What does it mean when NETs spread to the bones? How does this compare to other cancers?3. How are bone spots found and monitored? Should they be biopsied?4. What is the treatment for bone mets? Should I have radiation? Would radiation limit my ability to get PRRT?5. Should I be on bone strengthening medication? Am I at higher risk for fractures (or breaking my bones) if I have NETs in the bones?6. Do bone mets respond to PRRT?7. Does having bone mets put me at a higher risk of MDS?Brain mets:8. When and how often do NETs spread to the brain? Do all types of NETs have the potential to spread to the brain?9.    How are brain mets found and monitored? When should I suspect this?10.  How are brain mets treated? What does having brain mets mean for my life?*Bonus: What final words of hope do you have for the neuroendocrine cancer community?For more information, visit LACNETS.org.

Learn about the evidence-based techniques and tools of Stress Reappraisal. We delve into how changing your perception of your stress response can lead to better performance in settings like exams and public-speaking, can change your physiology and can positively impact those around you. Dr. Emily Hangen is a Visiting Assistant Professor at Fairfield University, Instructor at Harvard Extension School and is about to commence as an Assistant Professor at State University of New York Brockport. Chapters 0:00 Show Intro 2:35 Beliefs about stress 18:40 Stress vs. Stressor 23:00 Stress Reappraisal 36:20 Outcomes of Stress Reappraisal 50:08 Limitations of Stress Reappraisal 53:45 Implementing Stress Reappraisal Show Notes "Stress reappraisal during a mathematics competition: Testing effects on cardiovascular approach-oriented states and exploring the moderating role of gender" by Hangen et. al. (2019) "Get Excited: Reappraising Pre-Performance Anxiety as Excitement" by Brooks (2014) "Emotion regulation contagion: Stress reappraisal promotes challenge responses in teammates" by Oveis et. al. (2020) "Turning the knots in your stomach into bows: Reappraising arousal improves performance on the GRE" by Jamieson et. al. (2010) "Reappraising Stress Arousal Improves Performance and Reduces Evaluation Anxiety in Classroom Exam Situations" by Jamieson et. al. (2016) "Reappraising Stress Arousal Improves Affective, Neuroendocrine, and Academic Performance Outcomes in Community College Classrooms" by Jamieson et. al. (2022)

We all know that sleep is important, but sometimes we just don’t get enough. We also know the normal side effects from lack of sleep, but are there other, metabolic, and neuronendocrine effects from short sleep that we don’t know about. Host Aaron Lohr talks about this with Iris CM Pelsma, an academic researcher at Leiden University Medical Center in the Netherlands. She and her colleagues presented a study earlier this year, at ENDO 2023, titled, “Metabolic and Neuroendocrine Adaptability Following One Night of Partial Sleep Restriction in Dutch Males.” Show notes are available at https://www.endocrine.org/podcast/enp80-metabolic-and-neuroendocrine-effects-of-short-sleep — for helpful links or to hear more podcast episodes, visit https://www.endocrine.org/podcast

We all know that sleep is important, but sometimes we just don’t get enough. We also know the normal side effects from lack of sleep, but are there other, metabolic, and neuronendocrine effects from short sleep that we don’t know about. Host Aaron Lohr talks about this with Iris CM Pelsma, an academic researcher at Leiden University Medical Center in the Netherlands. She and her colleagues presented a study earlier this year, at ENDO 2023, titled, “Metabolic and Neuroendocrine Adaptability Following One Night of Partial Sleep Restriction in Dutch Males.” Show notes are available at https://www.endocrine.org/podcast/enp80-metabolic-and-neuroendocrine-effects-of-short-sleep — for helpful links or to hear more podcast episodes, visit https://www.endocrine.org/podcast

We all know that sleep is important, but sometimes we just don’t get enough. We also know the normal side effects from lack of sleep, but are there other, metabolic, and neuronendocrine effects from short sleep that we don’t know about. Host Aaron Lohr talks about this with Iris CM Pelsma, an academic researcher at Leiden University Medical Center in the Netherlands. She and her colleagues presented a study earlier this year, at ENDO 2023, titled, “Metabolic and Neuroendocrine Adaptability Following One Night of Partial Sleep Restriction in Dutch Males.” Show notes are available at https://www.endocrine.org/podcast/enp80-metabolic-and-neuroendocrine-effects-of-short-sleep — for helpful links or to hear more podcast episodes, visit https://www.endocrine.org/podcast

My guests today are Matt and Celeste Casey. A little over 2 years ago, a serious thing happened to him. His golf game started to suffer when he was losing to his friend Fuji. Real problems right.    After being poked, prodded, and scanned, Matt was found to have neuroendocrine cancer or NET, neuroendocrine tumors which took them to the gates of hell and back.    Join us for a lengthy tale of how a devoted and loving wife advocated for, and may have saved the life of, her husband by challenging the medical experts. It's a miracle he is still with us which gives him plenty of time to improve his golf skills. Neuroendocrine Cancer Awareness Huntsman Cancer Institute Neuroendocrine Cancer Awareness Institute Healing NET Foundation   Contact Matt and Celeste Email - mintjulepmomma@gmail.com Instagram - https://www.instagram.com/celeste.casey/ Facebook - https://www.facebook.com/Mintjulepmomma/   #GolfSavedMyLife #TIPSProcedure #CancerIsComplicated #NueroendocrineCancer #NETCancer #HuntsmanCancerInstitute #MyOncologistHasCancer #ZebraPrint #WeHaveCancer #MattAndCelesteCasey #LoudMouthWife #PatientAdvocate #AdvocateForYourself #Misdiagnosis #RenalFailure #HumbleDoctors #LaughterIsMedicine #SmallThroatHole

This 30-min CME program provides an overview of the latest clinical research presented at ENDO 2023 involving Cushing's disease.FacultyLisa Nachtigall, MDClinical Director, Neuroendocrine & Pituitary Tumor Clinical CenterMassachusetts General HospitalAssociate Professor of MedicineHarvard Medical SchoolLearning Objectives- After participating in the activity, learners should be better able to:- Describe the latest research being presented to better manage individuals with Cushing's disease and its clinical relevance.- Share new information with their clinical team.Supported by an educational grant from Recordati Rare Diseases, Inc.To obtain CME credit, go to https://checkrare.com/learning/p-cushings-disease-research-highlights-endo-2023/

It is frequently said that it takes a village to treat a patient with cancer. However, beyond the nuts and bolts of medical and allied health treatment, there exists a whole other world of advocacy and education. Charitable and not-for-profit foundations, both nationally and internationally, have done incredible work for many years in raising awareness and funding for cancer treatment and prevention, as well as providing both patient- and doctor-centred education. Oncology for the Inquisitive Mind is incredibly privileged to welcome the CEO of one such organisation, Meredith Cummins of Neuroendocrine Cancer Australia. Meredith brings decades of experience in oncology nursing, governance, fundraising and advocacy, and has done invaluable work in shining a light on the lesser-known challenges facing patients and doctors dealing with neuroendocrine cancers.Links from this episode:Neuroendocrine Cancer Australia: https://neuroendocrine.org.au/PLANET registry: https://neuroendocrine.org.au/planetregistry/COMPOSE study information: https://trials.cancervic.org.au/details.aspx?ID=feed-cta-trial444MoST framework: https://www.rarecancers.org.au/page/105/molecular-screening-and-therapeutics-most-#:~:text=MoST%20is%20a%20two%20part,treatments%20and%20new%20drug%20combinations.For more episodes, resources and blog posts, visit www.inquisitiveonc.comPlease find us on Twitter @InquisitiveOnc!If you want us to look at a specific trial or subject, email us at inquisitiveonc@gmail.comArt courtesy of Taryn SilverMusic courtesy of Music Unlimited: https://pixabay.com/users/music_unlimited-27600023/Disclaimer: This podcast is for educational purposes only. If you are unwell, seek medical advice. Hosted on Acast. See acast.com/privacy for more information.

"I have not failed, I've just found 10,000 ways that won't work!" so said Thomas Edison in describing his journey to the incandescent light bulb. This quote seemed appropraite as Michael and Josh conclude their journey in the neuroendocrine space and discuss neuroendocrine carcinomas (and poorly differentiated metastatic neuroendocrine tumours). Sometimes when you working in the oncological world, we all feel a bit like Thomas Edison, pouring sweat and tears into research that doesn't live up to expectations. But much like Thomas Edison, each step in this journey could revolutionise humanity or oncology, much like the CDK4/6 inhibitors, immunotherapy or tyrosine kinase inhibitors.But we aren't there yet. This week, Michael discusses the immunotherapy agent (Spartalizumab) while Josh goes old-school and discusses the TOPIC-NEC Japanese trial comparing etoposide and cisplatin (EP) to irinotecan and cisplatin (IP). Michael and Josh smell small cell similarities coming aboard the neuroendocrine express!Links to studies discussed in this episode (subscription may be required):TOPIC-NEC: https://jamanetwork.com/journals/jamaoncology/fullarticle/2795418Immunotherapy (Spartalizumab): https://erc.bioscientifica.com/view/journals/erc/28/3/ERC-20-0382.xml For more episodes, resources and blog posts, visit www.inquisitiveonc.comPlease find us on Twitter @InquisitiveOnc!If you want us to look at a specific trial or subject, email us at inquisitiveonc@gmail.comArt courtesy of Taryn SilverMusic courtesy of Music Unlimited: https://pixabay.com/users/music_unlimited-27600023/Disclaimer: This podcast is for educational purposes only. If you are unwell, seek medical advice. Hosted on Acast. See acast.com/privacy for more information.

Neuroendocrine Tumours could be described as an impassable obstacle, more complicated the more you research. That's where Michael and Josh come in, and this week, explore Grade 3 metastatic neuroendocrine tumours. Michael provides a brilliant overview of this well-differentiated cohort and the lack of efficacy platinum chemotherapies have, while Josh discusses CAPTEM (temozolomide and capecitabine) through a systematic review. Interestingly many of the current data is retrospectively collected, highlighting how challenging it is to collect enough patients to pursue meaningful research.Note- there is a quote from Lance Armstrong, who was stripped of his titles due to illegal doping (which we do not endorse); he did start the Livestrong Foundation to support those affected by cancer.Links to studies discussed in this episode (subscription may be required):1. Review - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158108/2. Cape/tem - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790144/3. Platinum-based chemo: https://erc.bioscientifica.com/view/journals/erc/20/5/649.xmlFor more episodes, resources and blog posts, visit www.inquisitiveonc.comPlease find us on Twitter @InquisitiveOnc!If you want us to look at a specific trial or subject, email us at inquisitiveonc@gmail.comArt courtesy of Taryn SilverMusic courtesy of Music Unlimited: https://pixabay.com/users/music_unlimited-27600023/Disclaimer: This podcast is for educational purposes only. If you are unwell, seek medical advice. Hosted on Acast. See acast.com/privacy for more information.

What are Grade 3 Poorly Differentiated Neuroendocrine Carcinoma (NEC)? What makes NEC unique? Can a NET transform to NEC? Dr Nitja Raj from Memorial Sloan Kettering Cancer Center in New York City explains NEC tumor biology and how it guides treatment strategy. She also discusses current clinical trials and research.For more information, visit LACNETS.org/podcast/24. For more information, visit LACNETS.org.

"We go to the moon and other places not because they are easy, but because they are hard." So spoke US President John F. Kennedy, in a speech that galvanised the American public and fostered widespread support for the space race and the Apollo space program that would culminate in Neil Armstrong and Buzz Aldrin landing on the Moon on July 20, 1969. A similar approach must be taken to the treatment of neuroendocrine tumours, a rare and difficult-to-treat cancer type requiring inventiveness, preparation and lateral thinking (almost) on the level of the Apollo and Soyuz astronauts.Last week, Michael and Josh discussed the front-line treatment of low-grade, well-differentiated neuroendocrine tumours. However, it always pays to be prepared. To that end, today our intrepid "onconauts" explore the lesser-known frontiers of later options, focussing on the competing everolimus and sunitinib. Will one option triumph over the other and reach the surface of the tumour first? Listen on to find out.Links to studies discussed in this episode (subscription may be required):RADIANT: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)00817-X/fulltextRaymond et al (sunitinib): https://www.nejm.org/doi/full/10.1056/nejmoa1003825For more episodes, resources and blog posts, visit www.inquisitiveonc.comPlease find us on Twitter @InquisitiveOnc!If you want us to look at a specific trial or subject, email us at inquisitiveonc@gmail.comArt courtesy of Taryn SilverMusic courtesy of Music Unlimited: https://pixabay.com/users/music_unlimited-27600023/Disclaimer: This podcast is for educational purposes only. If you are unwell, seek medical advice. Hosted on Acast. See acast.com/privacy for more information.

Neuroendocrine tumours (commonly referred to as NETs) is the topic for this week's episode of Oncology for the Inquisitive Mind. Michael and Josh thought it could be easily covered in a single episode, but they were wrong. This is not dissimilar to the recurrent cancellation of Futurama, a television series with nine lives saved by every network in existence.Neuroendocrine tumours are a diverse, heterogeneous, rare group of cancers that can occur throughout the body. The most common location is the gastrointestinal tract, lung, and pancreas. Of course, these aren't the only locations with NETs forming in the thymus, prostate, breast and skin. To complicate things further, the classification of NETs has changed multiple times over the past two decades.This first episode of our four-part "tour de force" will summarise well-differentiated neuroendocrine tumours and the pivotal studies of lanreotide and PRRT (peptide receptor radionucleotide therapy) with lutetium dotatate.Links to studies discussed in this episode (subscription may be required):1. Lanreotide - https://www.nejm.org/doi/full/10.1056/nejmoa13161582. PRRT - https://www.nejm.org/doi/full/10.1056/nejmoa16074273. NCCN guidelines: https://www.nccn.org/professionals/physician_gls/pdf/neuroendocrine.pdfFor more episodes, resources and blog posts, visit www.inquisitiveonc.comPlease find us on Twitter @InquisitiveOnc!If you want us to look at a specific trial or subject, email us at inquisitiveonc@gmail.comArt courtesy of Taryn SilverMusic courtesy of Music Unlimited: https://pixabay.com/users/music_unlimited-27600023/Disclaimer: This podcast is for educational purposes only. If you are unwell, seek medical advice. Hosted on Acast. See acast.com/privacy for more information.

David McBee is a highly accomplished keynote speaker, digital marketing expert, and sought-after marketing consultant. As an industry veteran, he provides updates and comprehensive training on programmatic advertising, targeted ads, and connected TV through his podcast, Simpli.fi TV and in-person presentations. David has helped numerous business owners with SEO, paid search, social media, and web design. Besides his professional achievements, he is also the author of the self-improvement book, Everyday Lessons Every Day as well as the popular children's book series, DJ's Off-Road Adventures. David enjoys reading, healthy living, the outdoors, and traveling with his family. In this episode, David shares his journey with neuroendocrine tumor cancer (NETs), a rare form of cancer. He discusses the symptoms he experienced and provides insights into his treatment and recovery. This episode offers a unique perspective on navigating cancer and life.  Tune in to hear his inspiring story!  ✨A few highlights from the show:    [00:02:52] Neuroendocrine tumor cancer.  [00:04:35] Major surgery and recovery.  [00:10:00] Anger and cancer correlation.  [00:13:14] Stress and its impact on health.  [00:15:52] The monster in the closet.  [00:20:05] Work why and reason for living.  [00:26:29] Taking proactive steps for cancer prevention.  [00:31:10] David's books and inspiration. [00:36:18] Doing what you love. Resources Mentioned: Man Up to Cancer, https://www.manuptocancer.com/  Dream Do, https://youtu.be/k8NtbM62cwQ?si=BIDNHEX4DatF8W8J   

The episode focuses on increasing dopamine, a neurotransmitter involved in focus, motivation, reward, pleasure, and happiness. Nurse Doza recommends taking vitamin B9, particularly the methylated form called 5MTHF, to support dopamine production. He explains that many people are deficient in B9 and warns against using the inferior form called folic acid. The host also mentions his personal experience with methylation difficulties and the importance of methylation for dopamine production.   TIMESTAMPS: 00:00 START 02:30 Increasing dopamine. 03:42 Vitamin B9 and dopamine production. 07:21 Vitamin B9 and focus. 11:17 Boost for natural energy. 15:28 Increasing healthy dopamine. 18:49 The role of SAMe in depression. 21:33 Increase dopamine for productivity. 25:12 Supporting the COMT Gene. 27:38 Supporting genetics and mental health.   --- Today's podcast episode is sponsored by BLISS, the newest tart lemon flavored sublingual supplement in the wellness market. Designed to give your serotonin and dopamine levels a healthy boost, BLISS not only supports your mood but also enhances your overall well-being. Just a quick drop under your tongue for 30 seconds, and you'll experience the difference. Click the link in our description to get your hands on BLISS.  https://www.mswnutrition.com/collections/best/products/bliss/?ref=baldo use CODE: NURSEDOZA for a discount --- Show Notes Today, we're sharing scientifically-backed tips to naturally enhance your dopamine levels. Get ready to take notes!  Tip 1: B9 Vitamin Intake^1,2^ Vitamin B9 plays a crucial role in the synthesis of serotonin and dopamine, the neurotransmitters that regulate mood^1^. It's associated with psychiatric symptoms, and its neuroprotective benefits are lost when patients lack a specific genetic enzyme, which converts folate/folic acid to its most usable form, L-methylfolate. This allows for the synthesis of the three major neurochemicals-serotonin, nor-epinephrine, and dopamine-across the blood-brain barrier^2^.  Studies:  1. [Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019700/)  2. [Vitamin B Supplementation: What's the Right Choice for Your Patients?](https://pubmed.ncbi.nlm.nih.gov/28671236/) Tip 2: Vitamin B6 Intake^1,2^ Vitamin B6-dependent enzyme in the brain, the aromatic L-amino acid decarboxylase, catalyzes the synthesis of dopamine from phenylalanine^1^. Evidence suggests that B6 undernutrition can lead to a loss of dopamine in the brain^2^. Studies: 1. [Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019700/) 2. [Effect of vitamin B-6 nutrition on the levels of dopamine, dopamine metabolites, dopa decarboxylase activity, tyrosine, and GABA in the developing rat corpus striatum](https://pubmed.ncbi.nlm.nih.gov/2761676/) Tip 3: Take SAMe^1,2,3,4^ SAMe is an endogenous amino acid metabolite and enzyme co-substrate involved in multiple biochemical pathways, including biosynthesis of hormones and neurotransmitters. Studies suggest that SAMe may increase the dopaminergic tone in the brain^2,3,4^. Studies: 1. [THE ADRENAL GLANDS PART I: THE ADRENAL MEDULLA](https://www.sciencedirect.com/science/article/abs/pii/B9780702033728000057) 2. [S-Adenosylmethionine (SAMe) for Neuropsychiatric Disorders: A Clinician-Oriented Review of Research](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501081/) 3. [Oral S-adenosylmethionine (SAM) Administration Increases Whole Brain Concentrations of Dopamine and Norepinephrine in Rats](https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.29.1_supplement.134.3) 4. [Neuroendocrine effects of S-adenosyl-L-methionine, a novel putative antidepressant](https://pubmed.ncbi.nlm.nih.gov/2120432/) Tip 4: Copper Intake^1^ Dietary copper deficiency is associated with a reduction in dopamine^1^.  Studies:  1. [Copper: from neurotransmission to neuroproteostasis](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080678/) Tip 5: Support the COMT Gene - Quercetin^1,2,3,4,5,6,7^ The catechol-O-methyltransferase (COMT) gene, involved in dopamine metabolism, and the MTHFR gene, affecting COMT methylation and function, are critical in maintaining dopamine levels. Quercetin, through its COMT-inhibiting properties, might potentiate dopamine effects^6^. Studies:  1. [Catechol-O-Methyltransferase Genotype and Dopamine Regulation in the Human Brain](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742018/) 2. [Quantitative role of COMT in dopamine clearance in the prefrontal cortex of freely moving mice](https://onlinelibrary.wiley.com/doi/epdf/10.1111/j.1471-4159.2010.06889.x) 3. [Role of catechol-O-methyltransferase (COMT)-dependent processes in Parkinson's disease and L-DOPA treatment](https://pubmed.ncbi.nlm.nih.gov/22483291/) 4. [Tyrosine Hydroxylase and Regulation of Dopamine Synthesis](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065393/) 5. [A potential interaction between COMT and MTHFR genetic variants in Han Chinese patients with bipolar II disorder](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351536/) 6. [Quercetin potentiates L-Dopa reversal of drug-induced catalepsy in rats: possible COMT/MAO inhibition](https://pubmed.ncbi.nlm.nih.gov/12711835/) 7. [Quercetin increased bioavailability and decreased methylation of green tea polyphenols in vitro and in vivo](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590855/) --- Before we sign off, don't forget about our sponsor BLISS. Just drop under the tongue and you're paving the way to healthier levels of serotonin and dopamine. This tart lemon sublingual supplement is a game-changer, bringing a blissful transformation to your day-to-day life. Don't miss out on this wellness opportunity! Click the link in our description to purchase BLISS now. Remember, a healthier, happier you is just a drop away! https://www.mswnutrition.com/collections/best/products/bliss/?ref=bliss ---

References Dr. Guerra's lipid lectures J Diabetes Investig. 2019 Nov; 10(6): 1430–1437. --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message

References Dr. Guerra's lecture archives. --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message

A new editorial paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 8, entitled, “The senescence-associated secretory phenotype induces neuroendocrine transdifferentiation.” In this editorial, researchers Anda Huna, Nadine Martin and David Bernard from the Université de Lyon discuss the senescence-associated secretory phenotype (SASP). SASP, in addition to stable proliferation arrest, is one of the most remarkable characteristics of senescent cells. Indeed, these cells secrete a variety of factors including cytokines, growth factors and matrix metalloproteases among others. In response to stress, through their SASP, senescent cells are able to modify and instruct their microenvironment. “The SASP is known to have several, sometimes contradictory, effects on phenotypes, including the induction or reinforcement of senescence in neighboring cells, promotion or inhibition of stemness, modification of extracellular matrix, activation or inhibition of immune responses and induction of epithelial-mesenchymal transition and cell migration.” Although cellular senescence and its SASP can initially display some beneficial effects, for instance favoring wound healing or blocking tumor initiation, accumulation of senescent cells and their secretome during aging or chronic stresses (tobacco, obesity, alcohol among others) plays a significant role in promoting aging-associated features and pathologies, like fibrosis, steatosis, chronic inflammation or cancer. In the context of cancer, senescence initially has an antitumoral role, as it promotes proliferation arrest and favors an anti-tumoral immune surveillance in response to oncogenic stress or DNA damage accumulation. However, SASP plays a dual role in tumor initiation and progression, as it first has a tumor suppressive action by reinforcing senescence in neighboring cells and recruiting immune cells, but also plays a tumor promoting role by promoting stemness, epithelial-mesenchymal transition and cell migration and by inhibiting immune responses. “Overall our work reveals a new effect of senescent cells and their SASP in tumors and offers new insights into NED [neuroendocrine transdifferentiation] in breast and prostate cancer biology. It also provides a new vision of the contribution of senescent cells and their SASP to aging-related pathologies, which could involve NED induction in some contexts.” DOI - https://doi.org/10.18632/aging.204669 Corresponding author - David Bernard - david.bernard@lyon.unicancer.fr Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.204669 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, cellular senescence, aging, cancer, NF-κB, calcium signaling About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at https://www.Aging-US.com​​ and connect with us: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ Twitter - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM

Today Maria opens up about her recent cancer & health journey and answers all of your burning questions! She shares about her initial symptoms, the scan she received that led to her diagnosis, and how she healed and recovered. She also shares the best advice on how to be the CEO of your health and truly advocate for yourself!  WE talk: -Maria's in-depth symptoms -How and why she got the Prenuvo scan  -Maria's surgery & hospital stay -Why googling your symptoms may actually be a good thing -What to do when you don't feel heard by your doctor -Why we have to prioritize our health -What Maria's energy healers told her through the process -Getting healthy for the arrival of her baby -How Maria stayed so strong throughout -Neuroendocrine vs. pancreatic cancer -Prenuvo scan giveaway & discount code  To get a $300 discount to the price of a whole body scan across current locations (LA, SF, NYC, Dallas, Boca Raton, Chicago and Minneapolis) and upcoming (Boston, DC and Atlanta) US locations go to: prenuvo.com/Maria (full link must be clicked and discount is automatically applied) For over the phone bookings: Simply mention the code Maria  HEAL SQUAD SOCIALS IG: @HealSquad TikTok: @HealSquadxMaria APPLE PODCASTS: https://podcasts.apple.com/us/podcast/heal-squad-x-maria-menounos/id1320060107 SPOTIFY: https://open.spotify.com/show/2kXrmaNDQQ4i6prZe6LO89?si=19af23c6154943d0 HEAL SQUAD RESOURCES: Website: www.mariamenounos.com Curated Macy's Page: macys.com/healsquad Amazon Storefront: https://www.amazon.com/shop/mariamenounos Patreon: https://patreon.com/HealSquad?utm_medium=clipboard_copy&utm_source=copyLink&utm_campaign=creatorshare_creator&utm_content=join_link ABOUT MARIA MENOUNOS: Emmy Award-winning journalist, TV personality, actress, 2x NYT best-selling author, former pro-wrestler and brain tumor survivor, Maria Menounos' passion is to see others heal and to get better in all areas of life. ABOUT HEAL SQUAD x MARIA MENOUNOS: A daily digital talk-show that brings you the world's leading healers, experts, and celebrities to share groundbreaking secrets and tips to getting better in all areas of life. DISCLAIMER: This Podcast and all related content [published or distributed by or on behalf of Maria Menounos or Mariamenounos.com] is for informational purposes only and may include information that is general in nature and that is not specific to you. Any information or opinions expressed or contained herein are not intended to serve as or replace medical advice, nor to diagnose, prescribe or treat any disease, condition, illness or injury, and you should consult the health care professional of your choice regarding all matters concerning your health, including before beginning any exercise, weight loss, or health care program. If you have, or suspect you may have, a health-care emergency, please contact a qualified health care professional for treatment. Any information or opinions provided by guest experts or hosts featured within website or on Company's Podcast are their own; not those of Maria Menounos or the Company. Accordingly, Maria Menounos and the Company cannot be responsible for any results or consequences or actions you may take based on such information or opinions.

References Int J Mol Sci. 2020 Jun; 21(11): 4098. --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message

Fabiola Gomes is a personal trainer and dance instructor who is originally from Brazil and now lives in San Diego. She is passionate about health and fitness and describes herself as a “health nut”, often using all-natural products whenever possible as cancer was one of her biggest fears. She eventually had to face that fear when she was diagnosed with a Neuroendocrine tumor on her pancreas in 2021. This was the start of a long and difficult journey that she feels has made her even stronger today. Tune in to episode 244 of the podcast to hear Fabiola's story, learn about her mental approach to fighting cancer, and much more. To stay in touch with Fabiola and follow her journey, visit https://www.instagram.com/fabulousfabdancefit/ or https://www.facebook.com/fabiolagomesdance To learn more about Project Purple, visit https://www.projectpurple.org/ or follow us on social media at these links: https://www.facebook.com/Run4ProjectPurple https://www.instagram.com/projectpurple/ https://twitter.com/Run4Purple https://www.youtube.com/channel/UCgA8nVhUY6_MLj5z3rnDQZQ

In this episode of CUBIST, Amanda and Don discuss the article, "Relation of mild traumatic brain injury history to abnormalities on a preliminary neuroendocrine screen; a Multi-Center LIMBIC-CENC Analysis,” by Bill Walker and colleagues and published in Brain Injury in May of 2022. Article Citation:
Walker, W. C., Werner, J., Agyemang, A., Allen, C., Resch, J., Troyanskaya, M., & Kenney, K. (2022). Relation of Mild Traumatic Brain Injury history to abnormalities on a preliminary Neuroendocrine screen; A multicenter LIMBIC-CENC analysis. Brain injury, 36(5), 607–619. https://doi.org/10.1080/02699052.2022.2068185 Article LINK: https://pubmed.ncbi.nlm.nih.gov/35507697/ CUBIST is a podcast for healthcare providers produced by the Traumatic Brain Injury Center of Excellence. We discuss the latest research on traumatic brain injury (TBI) most relevant to patient care. For more about TBI, including clinical tools, go to www.health.mil/TBICoE or email us at dha.ncr.j-9.mbx.tbicoe-info@mail.mil. The views, opinions, and/or findings in this podcast are those of the host and subject matter experts. They should not be construed as an official Department of Defense position, policy, or decision unless designated by other official documentation. Our theme song is “Upbeat-Corporate' by WhiteCat, available and was used according to the Creative Commons Attribution-Noncommercial 4.0 license.

In today's podcast we talk about stress related to grief. One of the greatest stresses that we experience as humans and that is the loss of a loved one. Loss, stress and grief can also be related to the end of a relationship for example because of a divorce or a breakup or even the end of a friendship. It could be related to the loss of a job, needing to move homes or the loss of a pet.   The stages of grief are not necessarily linear; we can even go through all of them in a day.   We may feel denial, being in shock, anger, guilt and fear. We may also experience depression and sadness.    It's also important to allow ourselves to experience grief the way that it happens for each of us individually.   I want to share with you more about the research related to how loss and grief create stress on our bodies. In a study from 2012 they found there is definitely a change in our cortisol and adrenaline levels when we experience loss.1   One of the areas that I have been researching for over 20 years is measuring cortisol and adrenaline levels in myself and my patients and understanding how we are all unique in terms of how our cortisol and adrenaline shifts when we're under stress.   I find it very interesting that the studies on loss and death of a loved one showed that it's more common for cortisol and adrenaline to be elevated in the first two weeks to six months after the loss. A year after the loss, if people continue to have symptoms of grief, they are more likely to have low cortisol levels.    It's really important to know how your body is responding because then we can do something about it and recover. We can start regulating our adrenaline and cortisol levels so this doesn't become a long term or permanent issue.    We can work to reset the HPA Axis (hypothalamic pituitary adrenal axis) to tell our bodies to produce more or less cortisol and adrenaline and regulate our stress response.   Studies also show that when a person experiences loss, it can increase the likelihood of experiencing anxiety and depression. Also, our immune system can be affected, and we can experience higher levels of inflammation in the body.2   Many other health problems can develop when under high stress, such as insomnia, heart attacks, strokes, cancer, increased susceptibility to viruses, such as HPV, and other infections. There is even a condition known as broken heart syndrome, or Takotsubo, when the heart muscle is weakened from grief and severe stress.3   When we're in a grieving process that has disrupted our neuroendocrine (nervous system and hormones) is when we need to have our cortisol and adrenaline levels measured.    This is not done in the standard medical office so that's why I offer these tests through my office, so you can do them yourself at home. You can find these on the links below. Then you and I can meet, and I can help you understand your results and how to address them and use the right protocol of nutrients and herbs for you.   https://doctordoni.com/product/assess-your-stress-type/    And this is not a one-size-fits-all treatment. Not everyone needs the same nutrients and herbs. It is crucial that we understand how our bodies respond to stress as an individual, and what doses and supplements are needed for our bodies to start healing.     In my latest book “Master Your Stress, Reset Your Health” (https://doctordoni.com/master-your-stress/) I identified the correct sequence for helping you to get your cortisol, adrenaline and neurotransmitters back to optimal again, and it's based on what I refer to as your unique Stress Type.    Once we know your Stress Type, we can help you to efficiently implement the nutrients and herbs that will help bring your levels back to optimal.    -   You can find which is your unique Stress Type by taking my Stress Quiz here: https://doctordoni.com/quiz      I have also set up the stress type supplement bundles where you can get just the right supplements for your specific stress type. You can find these bundles in my store here: https://doctordoni.com/product-category/dr-doni-products/dr-doni-packages/    This is how passionate I am about helping you to recover from stress, including stress from loss of a loved one, so you can prevent the health issues associated with grief and so that you can be thriving in your life.    If I can be of more assistance, please don't hesitate to reach out to me to set up a one-on-one appointment if you prefer: https://doctordoni.com/work-with-me/    You can also check out my most recent free masterclass: Transform Your Life: Get to the Root of Anxiety and Depression: https://doctordoni.com/transformanxiety/#blank-1    We're here to help you!   -   References:    Buckley T, Sunari D, Marshall A, Bartrop R, McKinley S, Tofler G. Physiological correlates of bereavement and the impact of bereavement interventions. Dialogues Clin Neurosci. 2012 Jun;14(2):129-39. doi: 10.31887/DCNS.2012.14.2/tbuckley. PMID: 22754285; PMCID: PMC3384441.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384441/   Hopf, D, Eckstein, M, Aguilar-Raab, C, Warth, M, Ditzen, B. Neuroendocrine mechanisms of grief and bereavement: A systematic review and implications for future interventions. J Neuroendocrinol. 2020; 32:e12887. https://doi.org/10.1111/jne.12887   What is takotsubo cardiomyopathy?   https://www.bhf.org.uk/informationsupport/conditions/cardiomyopathy/takotsubo-cardiomyopathy#:~:text=What%20is%20takotsubo%20cardiomyopathy%3F,extreme%20emotional%20or%20physical%20stress  -   Connect with Dr. Doni:    Facebook HTTPS://FACEBOOK.COM/DRDONIWILSON   Instagram HTTPS://INSTAGRAM.COM/DRDONIWILSON   YouTube HTTPS://YOUTUBE.COM/USER/DONIWILSONND   Weekly Wellness Wisdom Newsletter: HTTPS://DOCTORDONI.COM/WWW     -   Books and Resources:    Order My New Book: https://www.amazon.com/Master-Your-Stress-Reset-Health/dp/1953295576   Stress Warrior Book (FREE)  HTTPS://DOCTORDONI.COM/STRESSWARRIOR      Stress Warrior Stress Resiliency Facebook Group (FREE)  HTTPS://FACEBOOK.COM/GROUPS/STRESSWARRIOR     7-day Stress Reset (FREE)  HTTPS://DOCTORDONI.COM/STRESS-RESET     HPV & Cervical Dysplasia Guide (FREE)  HTTPS://DOCTORDONI.COM/HPV-AND-CERVICAL-DYSPLASIA-GUIDE/     -   Personalized Solutions:    If you'd like to meet with Dr. Doni one-on-one for your health, request a Health Breakthrough Session: HTTPS://DOCTORDONI.COM/BREAKTHROUGH     To get an idea of more comprehensive options, read about Dr. Doni's Signature Consultation Programs: HTTPS://DOCTORDONI.COM/SERVICES   Disclosure: Some of the links in this post are product links and affiliate links and if you go through them to make a purchase I will earn a commission at no cost to you. Keep in mind that I link these companies and their products because of their quality and not because of the commission I receive from your purchases. The decision is yours, and whether or not you decide to buy something is completely up to you.

Dr Pamela Kunz from the Yale Cancer Center in Palo Alto, California, discusses recent therapeutic advances in neuroendocrine tumors. CME information and select publications here (http://www.researchtopractice.com/OncologyTodayNeuroendocrine22).

Drs Iams and Shah discuss the process of diagnosing Lambert-Eaton myasthenic syndrome in neuroendocrine cancers, how the condition affects patient prognoses, and the primary goals of delivering coordinated care with in combination with cancer treatments.

Neuroendocrine tumors represent an uncommon type of cancer that is best managed with a multidisciplinary approach by experts in this disease.  There is a wide range of tumor aggressiveness, prognosis, and potential treatment options which largely depends on how the cancer cells appear under the microscope.   In this episode of the All In Against Cancer podcast powered by the Ochsner Cancer Institute, host Dr. Jonathan Mizrahi talks with Ochsner medical oncologist, Dr. Lingling Du, and Ochsner interventional radiologist, Dr. Andrew Marsala, about neuroendocrine tumors.  Both Dr. Du and Dr. Marsala specialize in the management of neuroendocrine tumors and are members of the Ochsner Neuroendocrine Tumor Team. Tune in to hear more about the approach to diagnosis and treatment of neuroendocrine tumors.

Today's guest is Andrew Heyman, MD, Fellowship Director, Integrative Medicine Programs (INTM), at the GW School of Medicine and Health Sciences. Founding medical director of the INTM Programs, Dr. Heyman is an expert on stress response and neuroendocrine system. We discuss the physiologic stress response, evaluate the impact of cortisol on nervous and immune system, examine common illnesses in the context of hypocortisol states that mediated disease progression and prognosis, and treatment strategies. Dr. Heyman's research interests include the stress response and neuroendocrinology, cardiometabolic disease, men's health, and clinical outcome research methodologies. (Originally published in April 2019) ◘ Related Content Chronic Stress and the HPA Axis: Clinical Assessment and Therapeutic Considerations bit.ly/3hYgJk0 The effects of chronic stress on health: new insights into the molecular mechanisms of brain–body communication bit.ly/31YXl0T Understanding the stress response: Chronic activation of this survival mechanism impairs health bit.ly/3jFVYKm ◘ Transcript bit.ly/2QVe12R ◘ This podcast features the song “Follow Your Dreams” (freemusicarchive.org/music/Scott_Ho…ur_Dreams_1918) by Scott Holmes, available under a Creative Commons Attribution-Noncommercial (01https://creativecommons.org/licenses/by-nc/4.0/) license. ◘ Disclaimer: The content and information shared in GW Integrative Medicine is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in GW Integrative Medicine represent the opinions of the host(s) and their guest(s). For medical advice, diagnosis, and/or treatment, please consult a medical professional.