Neurotech Pub

This episode features Paradromics CEO Matt Angle in a compelling discussion with Grayson Zulauf, CEO of Resonant Link; Alex Yeh, CTO and VP of R&D at Neuspera Medical; and Jacob Robinson, Founder and CEO of Motif Neurotech. They explore the latest advancements in neurotechnology, focusing on wireless power transfer, implantable devices, and brain-computer interfaces (BCIs). The conversation highlights transformative innovations in treating mental health conditions like major depressive disorder, OCD, and ADHD with less invasive wireless devices, enhancing patient care and acceptance. Personal stories and insights on market expansion and patient-friendly treatments are shared, along with valuable advice for investors on the potential of neurotechnology in improving overall mental health and medical care.Guest Quote:“The message that I would want to send is, there is a future in which we look at neurotechnologies no differently than we look at cardiac pacemakers.These are life saving devices, in many cases less invasive than a device that goes in your heart. There's no reason why  anybody wouldn't want to feel better. To be healthier mentally and just live a better quality of life. So that's what we're trying to enable” - Jacob RobinsonShow Notes:*(00:00) Welcome to Neurotech Pub*(00:46) Meet the Guests*(02:45) Discussing Industry Competitors*(09:54) Wireless Power Transfer in Medical Devices*(16:38) Exploring Inductive and Magnetoelectric Power*(27:35) Ultrasound in real-world devices*(33:31) Patient Experience and Device Miniaturization*(36:24) Designing for Patient Comfort and Practicality*(38:20) Innovations in Power and Data Transmission*(39:32) Miniaturization and Its Impact*(41:12) Battery Technology in Medical Devices*(43:19) Future of Implantable Batteries*(45:16) Implanted Battery Companies Integer and Resonetics*(46:31) Intermittent Stimulation and Therapy*(49:28) Power Consumption in Future Implants*(59:52) Data Transmission and Compression*(01:05:42) Reflections on the Journey of Medical Innovation*(01:08:36) Final Thoughts and Messages to InvestorsWant More?Follow Neurotech Pub on TwitterFollow Paradromics on Twitter, LinkedIn, and InstagramFollow Matt on LinkedIn and Twitter

We're back with Part II of our two-part series on Connectomics! In part one we speculated on the legal and ethical implications of emerging technologies in the connectomics field. In part two, we don our lab coats and take a deep dive into the latest research tools, from fixation protocols for the preservation of neural tissue, to multimodal imaging techniques, to the machine intelligence designed to interpret massive data sets and reconstruct the vast neural circuits that make up the connectome. Our guests are:  Kenneth Hayworth, PhD, President and Co-Founder of the Brain Preservation Foundation, Senior Scientist at the Howard Hughes Medical Institute's Janelia Farm Research Campus (JFRC) Robert McIntyre, CEO at Nectome Jeremy Maitin-Shepard, PhD, Software Engineer–Connectomics at Google In this episode, Ken and Robert from part one return to the pub, and we are also joined by Jeremy Maitin-Shepard, an engineer and researcher at Google, who shares insights into some of the machine intelligence modalities being used to decode previously uncharted neural networks. Check out Jeremy's recent paper on BioRxiv, as well as his published work at Google. If you missed part one, you can listen and explore the show notes here. Cheers!Show Notes: 0:00 | Intro1:03 | Kenneth Hayworth, PhD1:12 | Robert McKintyre, CEO, Nectome1:17 | Jeremy Maitin-Shepard, PhD1:51 | Setting the record straight 3:09 | The nucleotide sequence of bacteriophage φX1744:22 | Frozen Zoo at San Diego Zoo12:01| Glutaraldehyde and reduction techniques for immunolabeling 17:39 | SWITCH Framework19:14 | Population Responses in V1 Encode Different Figures by Response Amplitude Enhanced mirror neuron network activity and effective connectivity during live interaction among female subjects Permeabilization-free en bloc immunohistochemistry for correlative microscopy 19:57 | Synaptic Signaling in Learning and Memory Structure and function of a neocortical synapse Engineering a memory with LTD and LTP Synapse-specific representation of the identity of overlapping memory engrams 20:28 | Ultrastructure of Dendritic SpinesStructure–stability–function relationships of dendritic spines 24:25 | Reconstructing the connectome 24:32 | Connectomics Research Team at Google 24:55 | Google x HHMI: Releasing the Drosophila Hemibrain Connectome 28:38 | Serial Block-Face Scanning Electron Microscopy 29:22 | Automated Serial Sections to Tape29:45 | Mapping connections in mouse neocortex30:59 | A connectome and analysis of the adult Drosophila central brain 32:14 | Expansion Microscopy34:37 | The future of connectomics 45:13 | Contribution of apical and basal dendrites to orientation encoding in mouse V1 L2/3 pyramidal neurons49:49 | Mice and rats achieve similar levels of performance in an adaptive decision-making task Want More?Follow Neurotech Pub on TwitterFollow Paradromics on Twitter, LinkedIn, and InstagramFollow Matt on LinkedIn and Twitter

Welcome back to Neurotech Pub! In this first installment of two episodes on Connectomics, host and Paradromics CEO Matt Angle kicks off a lively discussion on the rapidly accelerating research in the mapping, preservation, and reconstruction of the human connectome. We explore the ethical and legal ramifications of disruptive technology, and some of the unique challenges faced when driving innovation in emerging industries. Our guests are:  Nita Faraheny, JD, PhD, Everett Distinguished Professor of Law & Philosophy at Duke Law School, the Founding Director of Duke Science & Society, the Faculty Chair of the Duke MA in Bioethics & Science Policy, and principal investigator of SLAP Lab.  Kenneth Hayworth, PhD, President and Co-Founder of the Brain Preservation Foundation, Senior Scientist at the Howard Hughes Medical Institute's Janelia Farm Research Campus (JFRC) Robert McIntyre, CEO at Nectome As an exciting new development since the recording of this episode, Nita recently published a book, The Battle for Your Brain, which examines many topics in neuroethics, from Connectomics to Brain-Computer Interfaces. It is currently available on Amazon.Keep an eye out for part two in this series, which will take a deep dive into the latest technical and engineering innovations in the connectomics ecosystem. Coming soon!Please be advised that this episode contains a brief discussion of assisted suicide in a medical setting.Show Notes: 0:00 | Episode Intro 1:16 | Nita A. Farahany, JD, PhD1:21 | Kenneth Hayworth, PhD1:27 | Robert McKintyre, CEO, Nectome1:56 | Meeting of the minds 2:53 | Aldehyde-stabilized cryopreservation wins final phase of brain preservation prize3:56 | The Brain Preservation Foundation4:09 | Documentary series on the Brain Preservation Foundation5:21 | Letter of Support for Aldehyde Stabilized Cryopreservation (and ‘next steps' caveats)5:51 | Nita's 2018 Neuroethics Ted Talk 5:54 | International Neuroethics Society6:25 | Connectomics & new paths in neuroscience 8:10 | Allen Institute for Brain Science8:47 | A connectome and analysis of the adult Drosophila central brain9:33 | A visual intro to synaptic imaging in connectomics10:28 | The structure of the nervous system of the nematode Caenorhabditis elegans 11:16 | Mouse Connectome Project at CIC14:59 | Cryonics controversy 19:00 | Death, taxes, and synapses 20:51 | Uniform Law Commission21:08 | The Uniform Determination of Death Act24:25 | Watch Altered Carbon on Netflix25:49 | Understanding the “Loss of Chance” Doctrine 37:13 | Understanding Physician-Assisted Death, or ‘Death with Dignity' 40:21 | Euthanasia in the Netherlands46:01 | Autonomy, Dignity, and Consent to Harm, Rutgers Law Review Want More?Follow Neurotech Pub on TwitterFollow Paradromics on Twitter, LinkedIn, and InstagramFollow Matt on LinkedIn and Twitter

Welcome back to Neurotech Pub! In this episode we're talking about sleep–why we sleep, how sleep works on a neurophysiological level, and some of the emerging sleep technologies that are about to revolutionize this essential neural activity.  Our guests are Amy Kruse, PhD, General Partner at Prime Movers Lab, Ram Gurumoorthy, PhD, Founder and CTO of Stimscience & Somnee, and Luis de Lecea, PhD, Professor of Psychiatry and Behavioral Sciences at Stanford University School of Medicine. This episode also features a video introduction to sleep stages by Paradromics Intern Zoe Lalji. This is essential viewing if you're unfamiliar with the stages of sleep and want to follow along later in the episode. Cheers!Show Notes:  00:00 | Episode intro with Matt Angle and Amy Kruse1:07 | StimScience in Fast Company5:05 | Learned Motor Patterns Are Replayed in Human Motor Cortex during Sleep6:43 | Connect with Prime Movers Lab7:01 | PML on Medium7:45 | Introduction to Sleep StagesReferences: Stages of Sleep Overview REM vs Non-REM SleepSleep WalkingBenefits of REM SleepConsequences of low REM sleepImportance of Deep SleepCheck out Zoe's nonprofit organization, ALS Heroes, and her Ted Talk12:24 | Pulling all-nighters12:50 | Amy Kruse, PhD13:00 | Ram Gurumoorthy, PhD13:07 | Stimscience, now Somnee13:30 | Luis de Lecea, PhD18:26 | Gordon Rule, PhD18:40 | Knights of the Old Republic II: The Sith Lords (2004)19:50 | Why do we sleep?20:26 | Sleep drives metabolite clearance from the adult brain20:35 | Sleep & DNA Repair22:13 | Neural Activity can cause DNA damage23:22 | Jerry Seigal24:26 | DARPA Sleep Research24:55 | Fur seals and sleep25:08 | How do Whales and Dolphins Sleep Without Drowning?25:54 | Putting Humans in Stasis Is the Best Way of Getting Us to Mars27:36 | Sleep and Mortality28:09 | The Sleeping Brain: Harnessing the Power of the Glymphatic System through Lifestyle Choices28:27 | Giulio Tononi, MD, PhD28:45 | Sleep, Memory, and Plasticity28:52 | Sleep Cognition and Memory29:00 | Sleeping up and down the phylogenetic tree29:05 | Actually...worms do sleep29:20 | Decoding sleep29:36 | Fruit flies and their mini sleeps29:44 | Mapping sleep in the brain30:35 | Hypocretin-positive neurons31:17 | Clearly Matt slept through his midterm... again31:57 | The hypocretins/orexins: integrators of multiple physiological functions32:05 | Stress-sleep interactions33:30 | The Science of Narcolepsy35:08 | Equivalence of sleep deprivation and intoxication | Additional reference36:21 | Sleep Pressure: Homeostatic Sleep Drive 40:38 | EEG Visualization of electrodermal activity during sleep44:08 | Circuitry of Sleep Stages45:00 | Regional slow waves and spindles in human sleep | Local sleep in awake rats48:00 | Emerging Sleep Technologies1:00:56 | Hypothalamus and SleepWant More?Follow Neurotech Pub on TwitterFollow Paradromics on Twitter, LinkedIn, and InstagramFollow Matt on LinkedIn and Twitter

The Panel: Jan Scheuermann is an author and public speaker, and self-styled “professional lab rat.” She has spoken at DARPA, the Johns Hopkins Applied Physics Laboratory, and the National Convention of the ALS Association about her experience as a BCI trial participant at UPitt. She is the author of a fictional mystery novel, Sharp as a Cucumber, available on Amazon. You can find out more about Jan and book her for public speaking events on her website or connect with her on LinkedIn. Ian Burkhart is the President of the Ian Burkhart Foundation, which provides equipment not typically covered by insurance that improves independence for those with spinal cord injuries. He is also the Vice President of the North American Spinal Cord Injury Consortium, an advocacy organization that brings individuals with lived experience together with researchers to improve research, care, cure, and policy. In addition, Ian consults on medical device development and user interaction. Ian's latest project is the BCI Pioneers Coalition, a platform to connect BCI users, researchers, industry, and other stakeholder groups to discuss the future of Brain Computer Interfaces. You can visit him on his website or connect with him on LinkedIn, Twitter, and Instagram. Nathan Copeland is a neurotechnology consultant, speaker, and digital artist. He has spoken at numerous conventions around the world about his experiences in the lab and has been featured in many prominent publications including, but not limited to, Wired, MIT Tech Review, NPR, Fortune, and the Atlantic. He is the creator of the first BCI NFTs, available on OpenSea. You can connect with Nathan on Instagram, Twitter, and Linkedin. 00:00 | Intro0:14 | Neurotech Pub Episode 13: BCI Pioneers Part I0:47 | Neurotech Pub Episode 10: Business Models in Neurotech1:30 | BCI & Identity1:30 | New Yorker - Do Brain Implants Change Your Identity?2:09 | The Utah Array (Blackrock Neurotech)16:05 | Learn more about Hector in Part 117:14 | Talking Form Factors18:36 | CerePlex System22:36 | Support Systems in BCI Adoption38:35 | Get in Touch38:54 | The Ian Burkhart Foundation39:13 | Book Ian as a speaker39:25 | North American Spinal Cord Injury Consortium (NASCIC)40:04 | Where to find Ian40:19 | Contact Nathan40:25 | Nathan on Instagram, LinkedIn, and Twitter40:32 | Nathan's NFTs on OpenSeaLinks to Jan's lab photos and how to get in touch can be found hereWant More?Follow Paradromics on Twitter, LinkedIn, and InstagramFollow Blackrock Neurotech on Twitter, LinkedIn, and InstagramFollow Taryn on LinkedIn, Instagram, and TwitterFollow Matt on LinkedIn and Twitter

In this very special two part series in collaboration with Blackrock Neurotech, Paradromics CEO Matt Angle and Blackrock Creative Director Taryn Southern co-host a discussion with BCI research pioneers Jan Scheuermann, Ian Burkhart, and Nathan Copeland. In part one, we discuss their personal journeys to becoming BCI pioneers, implant experiences with the Utah Array,  their time in the lab, and some of their current projects. Learn more about Jan, Ian, and Nathan below and stay tuned for part two, coming in July 2022! The Panel: Jan Scheuermann is an author and public speaker, and self-styled “professional lab rat.” She has spoken at DARPA, the Johns Hopkins Applied Physics Laboratory, and the National Convention of the ALS Association about her experience as a BCI trial participant at UPitt. She is the author of a fictional mystery novel, Sharp as a Cucumber, available on Amazon. You can find out more about Jan and book her for public speaking events on her website or connect with her on LinkedIn. Ian Burkhart is the President of the Ian Burkhart Foundation, which provides equipment not typically covered by insurance that improves independence for those with spinal cord injuries. He is also the Vice President of the North American Spinal Cord Injury Consortium, an advocacy organization that brings individuals with lived experience together with researchers to improve research, care, cure, and policy. In addition, Ian consults on medical device development and user interaction. Ian's latest project is the BCI Pioneers Coalition, a platform to connect BCI users, researchers, industry, and other stakeholder groups to discuss the future of Brain Computer Interfaces. You can visit him on his website or connect with him on LinkedIn, Twitter, and Instagram. Nathan Copeland is a neurotechnology consultant, speaker, and digital artist. He has spoken at numerous conventions around the world about his experiences in the lab and has been featured in many prominent publications including, but not limited to, Wired, MIT Tech Review, NPR, Fortune, and the Atlantic. He is the creator of the first BCI NFTs, available on OpenSea. You can connect with Nathan on Instagram, Twitter, and Linkedin. 00:00 | Intro6:10 | Who came first?7:07 | Jan Scheuermann7:18 | Tim Hemmes & the UPitt/UPMC Team8:05 | New Yorker profile of Jan and the UPitt team8:55 | View Jan's photos from the lab10:10 | Nathan Copeland13:00 | Parietal Cortex13:22 | Saccade Movements14:12 | The Pioneer Experience16:04 | Neuro Life Study | Additional Reference | Interview with Ian | Archives of PMR18:15 | Mirror Therapy23:50 | Jan in the Pilot Seat25:07 | Ian's Experience in the Car Simulator25:53| Thinking About Thinking31:24 | Jan's novel, Sharp as a Cucumber37:37 | View Jan's photos from the lab38:04 | Andy Schwartz38:45 | Nathan's NFTs43:22 | Nathan's Instagram45:03 | 15 Minutes of Fame45:12 | A Presidential Greeting45:45 | Jan on 60 Minutes45:54 | Jan in SciAM46:00 | Book Jan as a keynote speaker46:32 | SfN47:05 | Investment in BCI47:17 | The Ian Burkhart FoundationWant More?Follow Paradromics on Twitter, LinkedIn, and InstagramFollow Blackrock Neurotech on Twitter, LinkedIn, and InstagramFollow Taryn on LinkedIn, Instagram, and TwitterFollow Matt on LinkedIn and Twitter

Welcome back to Neurotech Pub!This episode is part two of a two part series on optical methods for recording and stimulating neural activity. Our guests on this episode are Elizabeth Hillman, PhD,  Mark Schnitzer, PhD, and Jacob Robinson, PhD. Last time we talked about optical recording methods, but in this episode we focus on optical stimulation methods. Cheers!Check out video and full transcript here: https://www.paradromics.com/podcast/episode-12-mind-control-with-lasers00:00 | Intro1:37 | Aspirational Papers1:56 | Packer Lab 2:10 | What is the claustrum?2:30 | Ian's paper (but only part of it!)3:02 | Two-Photon Bidirectional Control and Imaging In Vivo3:29 | Inferring Spikes from Calcium Imaging5:45 | Neuropixels are now in humans7:12 | Paper by Pachitariu et al 7:55 | Ian Oldenburg10:02 | Kaufman Lab11:21 | Cortical activity in the null space: permitting preparation without movement12:08 | Motor cortical dynamics shaped by multiple distinct subspaces during naturalistic behavior12:33 | Tickling Cells with Light14:41 | Light-activated ion channels for remote control of neuronal firing14:50 | Remote Control of Behavior through Genetically Targeted Photostimulation of Neurons15:20 | Millisecond-timescale, genetically targeted optical control of neural activity16:03 | Red-shifted Opsins16:52 | eNpHR: a Natronomonas halorhodopsin enhanced for optogenetic applications17:26 | Genetically Targeted Optical Control of an Endogenous G Protein-Coupled Receptor18:16 | Neural Dust18:41 | Wireless magnetothermal deep brain stimulation19:05 | Neural Stimulation Through Ultrasound19:20 | Methods and Modalities: Sculpting Light21:35 | Recent advances in patterned photostimulation for optogenetics22:50 | Two-photon microscopy is now over 30 years old (Denk 1990)25:22 | Optical Recording State of the Art27:06 | Challenges of Deep Tissue 2-Photon Imaging28:21 | Deisseroth Lab28:29 | Temporal Precision of Optical Stimulation29:09 | Simultaneous all-optical manipulation and recording 30:40 | Targeted Ablation in Somatosensory Cortex 33:29 | Commercially Available Fast Opsins34:41 | Recent paper from Deisseroth Lab41:17 | Cortical layer–specific critical dynamics triggering perception42:21 | The Utah Array from Blackrock Neurotech44:52 | Principles of Corticocortical Communication50:43 | The Cost of Cortical Computation51:27 | Behaviour-dependent recruitment of long-range projection neurons in somatosensory cortex (2013) | Spatiotemporal convergence and divergence in the rat S1 "barrel" cortex (1987) | Diverse tuning underlies sparse activity in layer 2/3 vibrissal cortex of awake mice (2019) 52:56 | Gollisch and Meister 200853:22 | Spike Timing-Dependent Plasticity (STDP)1:05:09 | Neurotech Pub Episode 11 -  Let There Be Light1:05:20 | Forecasting the Future1:05:41 | Temporally precise single-cell-resolution optogenetics1:06:16 | Large Scale Ca++ Recordings from Vaziri Lab1:07:11 | Cohen Lab1:07:19 | All Optical Electrophysiology 1:14:19 | Emiliani et al 20151:16:33 | All-Optical Interrogation of Neural Circuits1:16:53 | Mice Strains @ Jackson Lab1:17:00 | The Allen Institute1:20:39 | Neuroscience and Engineering Collaborations1:18:39 | Nicolas Pegard1:18:47 | Adesnik Lab1:24:41 | Shenoy, Sahani, and Churchland 20131:24:52 | Dimensionality reduction for large-scale neural recordings1:25:17 | Matlab: Understanding Kalman Filters1:25:58 | Two-photon excitation microscopy1:26:37 | Emiliani Lab Holography course1:26:57 | Optics by Eugene Hecht1:28:05 | Intro to Optics Course1:29:41 | What the Heck Is a Claustrum?1:33:53 | Cortical activity in the null space: permitting preparation without movement1:34:33 | Neural Manifolds and Learning1:35:19 | Locked-in Syndrome1:36:58 | Sabatini Lab1:37:07 | Probing and regulating dysfunctional circuits using DBS1:39:36 | Sliman Bensmaia | Nicho Hatsopoulos1:39:43 | The science and engineering behind sensitized brain-controlled bionic hands1:41:20 | Michael Long's singing rodents1:42:12 | Engram1:43:06 | Chang Lab1:43:19 | Tim Gardner | Michale FeeWant more? Follow Paradromics & Neurotech Pub on Twitter  Follow Matt A, Ian, Adam, & Matt K on Twitter

Welcome back to Neurotech Pub! This episode is one of a two part series on optical methods for recording and stimulating neural activity. Our guests on this episode are Elizabeth Hillman, PhD,  Mark Schnitzer, PhD, and Jacob Robinson, PhD. So far, our technical dives have focused mainly on direct electrical recording and stimulation of neural activity, but in this episode we deep dive into advantages that all-optical interfaces might have over electrical interfaces, and the challenges in developing them. In addition, we talk about running highly collaborative, interdisciplinary projects that span traditional physics and engineering with biology, a theme that is ever-present in neurotech and is also highlighted in part two of this series. Cheers!Check out full video with transcript here: https://www.paradromics.com/podcast/episode-11-let-there-be-lightShow NotesLatest news & publications since recording: >> Hillman Lab: New publication on SCAPE in Nature Biomedical Engineering>> Robinson Lab: Review article in Optica on Recent advances in lensless imaging>> Robinson Lab: BioRxiv pre-print on in vivo fluorescence imaging1:23 | The Heart and Soul of a Paper2:32| Ultrasmall Mode Volumes in Dielectric Optical Microcavities3:01 | Robinson Lab4:01 | Hillman Lab4:07 | Zuckerman Institute4:15 | Schnitzer Lab4:25 | Howard Hughes Medical Institute4:41| Miniature Fluorescence Microscope9:02 | Discovery of DNA Structure and Function10:25 | Hodgkin–Huxley Equations13:49 | Vessel Dilation in the Brain16:03 | State of the art of Neural Optical Recording18:03 | Long-Term Optical Access to an Estimated One Million Neurons in Mouse Cortex24:56 | Watch the Crystal Skull video27:45 | High-Speed Cellular-Resolution Light Beads Microscopy29:54 | Relationship between spiking activity and calcium imaging32:50 | Analytical & Quantitative Light Microscopy [AQLM]32:59 | Imaging Structure & Function in the Nervous System35:22 | NIH Brain Initiative Cell Census Network (BICCN)35:54 | Allen Brain Atlas: Cell Types40:17 | A Theory of Multineuronal Dimensionality, Dynamics and Measurement46:19 | Dr. Laura Waller's DIY Diffuser Cam50:38 | FlatCam by Robinson Lab53:42 | Advantages of MEG55:06| Random Access Two Photon Scanning Techniques56:07 | Swept Confocally-Aligned Planar Excitation (SCAPE)58:47 | Optics Systems for Implantable BCIs1:00:43 | GCaMP - Janelia GECI reagents1:01:33 | DARPA NESD Program1:04:06 | SCAPE Microscopy for High-Speed Volumetric Imaging of Behaving Organisms1:07:00 | Glial Response to Implanted Electrodes1:07:07 | Brain Tissue Responses to Neural Implants1:09:36 | Two Deaths in Gene Therapy Trial for Rare Muscle Disease1:10:46 | Intrinsic Optical Signal due to Blood Oxygenation1:11:11 | Coupling Mechanism and Significance of the BOLD Signal1:12:10 | DARPA invests in Treating Mood Disorders1:12:57 | Amygdalar Representations of Pain1:13:48 | Fast Optical Signals: Principles, Methods, and Experimental Results1:14:12 | Dr. Larry Cohen's early work in Neurophotonics1:14:42 | Linear Systems Analysis of Functional Magnetic Resonance Imaging | Additional Resource1:16:20 | Flavoprotein Fluorescence Imaging in Neonates | Additional Resource1:18:02 | Pumped Probe Microscopy1:19:26 | Biological Imaging of Chemical Bonds by Stimulated Raman Scattering Microscopy1:19:36 | Coherent Anti-Stokes Raman Scattering microscopy (CARS)1:19:55 | Min Lab @ Columbia1:20:06 | Glucose Analog for Stimulated Raman Scattering1:20:39 | Emerging Paradigms for Aspiring NeurotechnologistsWant more? Follow Paradromics & Neurotech Pub on Twitter  Follow Matt, Elizabeth, Jacob & Mark 

Welcome back to the Season 2 premiere of Neurotech Pub!In this episode, host and Paradromics CEO Matt Angle sits down with fellow Founder/CEOs Carolina Aguilar, Brian Pepin, and Kunal Ghosh to talk shop about building cutting edge neurotech companies from the ground up. We dive deep into business strategies, the neurotech fundraising landscape, emerging therapeutics, and more. We also provide an insider's view of the intersections of data, pharma, and med devices that are shaping the future of healthcare. Pour yourself a cold one and settle in! Check out full video with transcript here: Check out video and a full episode transcript here. 00:00 | Updates & News >> INBRAIN Neuroelectronics raised a $17M Series A >> Rune Labs raised a $22.8 Million Series A >> Inscopix Launched Cloud-Based Platform for Data Management and Analysis2:15 | Meet the panel and pick up a book1:54 | Jester King Brewery  2:25 | Rune Labs  2:50 | Neurostimulator for deep brain stimulation therapy  3:23 | INBRAIN Neuroelectronics  4:11 | Inscopix  5:24 | Ursula K. Le Guin's 'The Dispossessed'  6:19 | Yuval Noah Harari's 'Sapiens: A Brief History of Humankind'  6:32 | Daniel G. Miller's 'The Tree of Knowledge'  6:40 | Jiddu Krishnamurti's 'The Book of Life'  7:34 | Barack Obama's 'A Promised Land,' ‘Dreams from my Father,' & ‘The Audacity of Hope'  7:56 | Karl Popper's 'The Open Society and Its Enemies'9:25 | Venture Capital in Neurotech34:44 | Business Strategy in Neurotech40:32 | Tom Oxley, CEO, Synchron  43:58 | Dr. Thomas Insel  44:06 | Mindstrong Mental Health Care  44:35 | Aduhelm controversy  52:25 | Galvani Bio  59:39 | Percept Neurostimulator  1:00:32 | Neuromodulation and the future of treating brain disease  1:07:21 | Software as a Medical Device FDA Guidance1:09:12 | State of Animal Model Systems1:14:28 | α-Synuclein in Parkinson's Disease  1:18:01 | Alto Neuroscience  1:18:36 | Flatiron Foundation  1:18:45 | Gaurdent Health  1:19:03 | Melanoma Trends & Rates1:21:41 | The Pharma-Data-Device Ecosystem 1:21:42 | Frank Fischer, Chairman of Neuropace  1:22:28 | Neurotech Pub Season 1, Episode 9  1:26:35 | Roche acquisition of Flatiron Health & merger with Foundation Medicine   1:27:12 | Companion Diagnostics  1:28:29 | Adhulem and PET imaging  1:29:09 | Resignations at the FDA over Alzheimer's Drug  1:29:32 | Derek Lowe's take on the Aducanumab Approval, FDA Committee Votes, Halting the Aducanumab Trials, & The FDA Advisory Committee Briefing Document on Aducanumab  1:31:39 | Donanemab receives breakthrough therapy designation in 2021  1:36:58 | Mapping the Frontal-Vagal Pathway  1:37:09 | The Human Connectome Project  1:40:07 | Teal Organizations and Holacracy  1:41:18 | Society for Neuroscience  1:44:37 | Affymetrix (Thermo Fisher Scientific)  1:44:39 | IlluminaWant more?Follow Paradromics & Neurotech Pub on Twitter  Follow Matt, Brian, Carolina, & Kunal on Twitter

Welcome to the Season 1 finale of Neurotech Pub! In this episode, host and Paradromics CEO, Matt Angle, speaks with fellow Neurotech CEOs, Konstantinos Alataris, Frank Fischer, and Marcus Gerhardt. "We cover a lot in this discussion, but one of the big themes is how challenging it can be to raise money, to build neuro devices. This episode was originally recorded last winter, and it was instantly one of my favorite episodes. So like a fine wine, I laid it down until the time was right to share it with friends.Since the episode was recorded, Nesos, Paradromics, and BlackRock all had major funding announcements. Nesos and BlackRock underwent rebranding campaigns, and NeuroPace went public on Nasdaq. This podcast was recorded during a bleak winter, but our optimism proved prescient. The podcast aged well, and now the field is the strongest, best funded, and most exciting that it's ever been. I know you'll enjoy the discussion."- Matt Angle, CEO, ParadromicsCheck out full video with transcript here: https://www.paradromics.com/podcast/neurotech-pub-episode-9-building-and-funding-neurotech-companies 01:08 | Meeting Heros08:02 | Company Origins: NeuroPace, Blackrock Neuro, and Nēsos25:28 | Now vs Then, a Decade of Neurotech Entrepreneurship1:04:50 | Investor Backing in Neurotech1:20:44 | BCI Future Is UnderwayWant more? Follow Paradromics & Neurotech Pub on Twitter  Follow Matt A, and Blackrock Neurotech on Twitter

Welcome back to Neurotech Pub!In this episode, host and Paradromics CEO, Matt Angle, brings together memory-researchers Nanthia Suthana (Assist. Prof. of Neurosurgery and Bioengineering, UCLA School of Medicine) and Gyorgy Buzsaki (Biggs Professor of Neuroscience, NYU School of Medicine), and scientist-entrepreneurs Dan Rizzuto (CEO of Nia Therapeutics) and Nick Halper (Co-Founder of Braingrade) to discuss memory, and memory enhancement applications of BCI. Like many of you I approached, and to some extent still do approach, the concept of memory enhancement with skepticism. But the conversation today is going to be a grounded one, and I think you will see that there is some real science here that can give us reason to be cautiously optimistic about the future of memory and BCI. I hope you enjoy the episode.- Matt AngleCheck out full video with transcript here: https://www.paradromics.com/podcast/neurotech-pub-episode-8-the-drinks-bring-back-all-the-memories 00:43 | Guest Introductions07:38 | Types of Memory26:47 | Building a Memory Prosthetic38:05 | Predicting the Future: BCI to Decode/Reconstruct Memory46:26 | Clinical Evidence of Modulating Memory1:02:52 | New Approaches For Enhancing Memory1:17:48 | Closing the Research-Clinical GapWant more? Follow Paradromics & Neurotech Pub on Twitter  Follow Matt A, Nanthia Suthana, Dan Rizzuto, and Nick Halper on Twitter

Welcome back to Neurotech Pub!In this episode, host and Paradromics CEO, Matt Angle, brings together Karen Rommelfanger (Neurotech Ethicist, Strategist, and Associate Professor at Emory), Anna Wexler (Assistant Professor of Medical Ethics and Health Policy at UPenn), Ana Maiques (CEO of Neuroelectrics), and Stephanie Naufel Thacker (Technical Program Manager at Facebook Reality Labs). We talk about the role of ethicists in tech. Stephanie announces a new collaboration between Facebook and the Columbia NeuroRights program. We discuss data privacy, and I am mostly listening except for two excursions on 409A valuations and Disney's The Little Mermaid.Check out full video with transcript here: https://www.paradromics.com/podcast/neurotech-pub-episode-7-neurotechnology-startups-and-the-e-word00:30 | Guest IntroductionsKaren Rommelfanger, PhDAna MaiquesStephanie Naufel Thacker, PhDAnna Wexler, PhD01:00 | The E Word27:29 | Innovative Businesses and Ethicists Collaboration44:05 | What Neural Data Can Reveal56:39 | Voices Not in the Room1:01:18 | Eroding Privilege of Mind-Body DualityWant more? Follow Paradromics & Neurotech Pub on Twitter  Follow Matt A, Karen Rommelfanger, Ana Maiques, & Anna Wexler, PhD on Twitter

Welcome back to Neurotech Pub!In this episode, host and Paradromics CEO, Matt Angle, discusses the science of olfaction with Andreas Schaefer, Gabe Lavella, and Dima Rinberg. Gabe and Dima also unveil their new startup, Canaery, which uses BCI-enhanced animals to digitize the olfactory world. Check out full video with transcript here: https://www.paradromics.com/podcast/neurotech-pub-episode-6-cyborgs-that-smell00:10 | Guest Introductions00:43 | What They Wanted to Be When They Were 8 Years Old09:21 | What You Don't Know About Olfaction That You Should 16:17 | Dimensionality in Olfactory Space22:26 | Architecture of the Olfactory System31:24 | Natural and Artificial Olfaction38:19 | State of the Art of Olfaction Neural Recording Modalities46:21 | Engineered Olfactory Receptors51:32 | Implications of High Data-Rate Olfactory BCI1:06:19 | Olfaction ResourcesWant more? Follow Paradromics & Neurotech Pub on Twitter  Follow Matt A Andreas Schaefer and Dima Rinberg on Twitter

Welcome back to Neurotech Pub!In this episode, host and Paradromics CEO, Matt Angle, discusses ethical considerations around brain-computer interfaces. Our guests are Tim Brown, Leigh Hochberg, Sydney Cash, and Amanda Pustilnik. A central theme in the discussions will be how neuroethics differ from traditional medical ethics or bioethics and what we can draw from other fields and experiences to prepare for a world where BCI is more prevalent and more powerful.Check out full video with transcript here: https://www.paradromics.com/podcast/neurotech-pub-episode-5-a-lawyer-a-philosopher-and-two-neurologists-walk-into-a-bar00:15 | Guest IntroductionsAmanda Pustilnik at Harvard LawDr. Tim Brown at University of WashingtonDr. Leigh Hochberg and BraingateDr. Syd Cash's Cortical Physiology Lab at MGH01:00 | Innately-Held Unproven Moral Beliefs01:00 | Neuroethics: A Field of Its Own06:57 | Device vs Pharmacological Brain Therapies21:01 | When Patients and Clinicians Don't See Eye-to-Eye41:11 | Researchers' Burden in Equitable BCI Dissemination51:05 | Data and Privacy in a BCI World1:06:04 | Legal Brain Data Protections, or Lack Thereof1:22:20 | Should BCI Eradicate Disability1:35:36 | Balancing Near-Term Utility and Long-Term HarmsNeurotech Pub is a podcast from Paradromics Inc, that features heavy-hitters from academia and industry in the field of Neurotech. But unlike a traditional panel, we bring you conversations that would normally happen after the conference, while unwinding at the pub. We hope you have enjoyed this discussion, for more please checkout our other episodes.Want more? Follow Paradromics & Neurotech Pub on Twitter  Follow Matt A, Tim Brown, Leigh Hochberg, Sydney Cash, and Amanda Pustilnik on Twitter

Welcome back to Neurotech Pub!In this episode, Vikash Gilja reprises his role as Vikash Gilja. We are also joined by Konrad Kording, Chethan Pandarinath, and Carsen Stringer. We talk about how dimensionality reduction is used to better understand large scale neural recordings. This episode is fairly technical, but it contains many great references if you are interested in learning more. We open with a brief explainer video by Paradromics' own Aditya Singh.Check out full video with transcript here: https://www.paradromics.com/podcast/neurotech-pub-episode-4-trading-spaces-dimensionality-reduction-for-neural-recordings00:40 | Dimensionality Intro04:42 | Podcast Start07:50 | Janelia Research Campus08:56 | Translational Neuroengineering Lab09:35 | Stanford Neural Prosthetics Translational Lab10:10 | Shenoy Lab12:00 | Deep Brain Stimulation12:57 | Chethan's work on retinal prosthetics15:00 | Immunology15:20 | Jonathan Ruben15:30 | Byron Yu15:41 | Gatsby Computational Neuroscience Unit18:00 | Joshua Tenenbaum18:30 | Kording Lab at UPenn18:46 | Neuromatch Academy19:47 | Neuromatch Academy Q&A21:21 | Dimensionality reduction for neural recordings26:22 | The Curse of Dimensionality30:11 | Principal Component Analysis32:20 | Neural Firing as a Poisson Process33:13 | Shared Variance Component Analysis35:18 | Cross validation in large scale recording38:29 | A theory of multineuronal dimensionality39:10 | Random projections explained with visuals42:24 | Correcting a reductionist bias48:30 | Noise Correlations49:35 | More on Noise Correlations57:40 | LFADS01:01:51 | What is a stationary process?01:06:02 | Inferring single-trial neural population dynamics01:06:46 | Task Specificity01:07:28 | Lee Miller01:08:18 | “I don't know, I might be wrong”01:13:16 | Neural Constraints on Learning01:15:00 | A recent exciting paper from Yu and Batista Labs01:19:01 | Hume on CausationWant more? Follow Paradromics & Neurotech Pub on Twitter  Follow Matt A, Konrad Kording, Chethan Pandarinath, and Carsen Stringer on Twitter.

Welcome back to Neurotech Pub!In this episode, host and Paradromics CEO, Matt Angle, speaks with Stuart Cogan, Vanessa Tolosa, Thomas Stieglitz, and Loren Rieth about how to protect neural implants from the harsh environment of the body. This discussion is all about longevity and endurance, and, fittingly, it's almost 2 hours long. Loren leaves early for a faculty meeting--wonder if his colleagues know that he came straight from the pub?Check out full video with transcript here: https://www.paradromics.com/podcast/neurotech-pub-episode-3-connectors-cans-and-coatings03:27 | UTD Neural Interfaces Lab03:39 | EIC Labs03:59 | Cogan's highly-cited review paper04:16 | Lawrence Livermore National Lab04:56 | Rieth Lab at the Feinstein Institute05:18 | Loren's work with the Utah Array05:39 | Human peripheral nerve stimulation05:58 | Preclinical Vegus Nerve stimulation06:11 | Stieglitz Lab06:22 | Flexible Electrodes06:41 | Long Lasting Electrodes07:41 | Jerry Loeb: Materials Legend08:29 | Phil Troyk09:24 | North American Neuromodulation Society10:44 | Melosh Lab at Stanford12:53 | Packaging Development17:02 | Helium Leak Test19:01  | Work by Pancrazio21:34 | Finetech-Brindley Stimulator29:05 | Emerging technology @ University of Sydney33:10 | Calvin and Hobbes34:12 | Revolutionizing Prosthetics35:00 | Canned Utah Array35:35 | Flip-chip connecting36:04 | Nick Donaldson: Mr. Clean36:47 | Failure mode analysis36:55 | Scaling up the Utah Array37:54 | DARPA's NESD Program38:28 | High density Utah Array39:52 | The Michigan Probe40:00 | Vanessa's work with Loren Frank42:05 | Parylene C encapsulation42:56 | Thin film44:15 | Clean rooms46:50 | NeuroRoots47:28| Test structures49:17 | Implant size50:35 | Testing strategies52:40 | NeuroNexus53:59 | Tissue response studies54:27 | Cogan Lab's work on Silicon Carbide56:10 | DARPA's HAPTIX Program56:30 | Reactive Accelerated Aging (RAA)58:15 | RAA with hydrogen peroxide58:55 | Deep Brain Stimulation01:02:55 | Hydrolysis01:09:00 | Silicon Carbide device01:10:26 | Neuropixels collaboration01:19:05 | Atomic Layer Deposition01:26:55 | Focused research orgs01:36:14 | Second Sight01:43:48 | Search for Paradise by Jens NaumaunnWant more? Follow Paradromics & Neurotech Pub on Twitter  Follow Matt A on Twitter.

Welcome back to Neurotech Pub!In this episode, host and Paradromics CEO, Matt Angle, speaks with Beata Jarosiewicz, Vikash Gilja, Sergey Stavisky, and Frank Willett about how brain computer interfaces can be used to restore communication in patients with tetraplegia. They take a deep dive into state of the art thought-to-text technology compared with the current state of speech decoding.Check out full video with transcript here: https://www.paradromics.com/podcast/neurotech-pub-episode-2-what-weve-got-here-is-failure-to-communicate 1:49 Braingate Clinical Trial Program |2:32 Beata's New Job at Neuralink |2:43 Stanford Neural Prosthetics Translational Laboratory |2:53 Leigh Hochberg |3:05 Andy Schwartz |5:14 2020 BCI Award|8:44 Subjective Experience of Control |10:39 Closed Loop Calibration |12:08 Animal Models for Prosthesis Development |14:21 Keyboard Optimization |15:33 Tablet PC Control Papers | See Also |16:01 Palm Pilot Graffiti |16:24 Frank's Preprint on Handwriting |17:40 Video Abstract on Frank's Work |21:38 Penfield and Boldrey 1937 |22:04 A Quick, Lay Summary of Penfield's Work |24:21 Hand Knob |26:43 Output-Null Neural State Space Dimensions |34:23 Matt Kaufman's Work |38:29 Vikash's work with Paul Nuyujukian |39:07 Mark Churchland |42:01 Review Paper by Eb Fetz |44:18 Chang Lab at UCSF |44:46 Robert Knight's Group on Speech Decoding | Imagined Speech |50:38 Speech Decoding in Hand Knob |50:55 Phoneme Decoding |52:48 Auditory Decoding in NHPs |54:58 Moses et al., 2019|55:12 Makin et al., 2020 |1:07:11 Nir's Paper on Error Signals |Want more? Follow Paradromics & Neurotech Pub on Twitter  Follow Matt A and Sergey Stavisky on Twitter

Welcome to Neurotech Pub, hosted by Paradromics Inc and SynBioBeta. In this episode, host and Paradromics CEO, Matt Angle, speaks with Tim Harris, Cindy Chestek, and Philip "Flip" Sabes about the big programmatic challenges in neurotechnology. We talk about the differences between labs, startups, and large research consortia. We discuss the difference between neuroscience and neuroengineering, and Tim explains how one of the biggest breakthroughs in neurophysiology was the product of….lawyers.Check out full video with transcript here: https://www.paradromics.com/podcast/neurotech-pub-episode-1-biologists-engineers-and-lawyers 2:04 Jester King Brewery, Dripping Springs, TX | 3:03 Bell Labs | 7:31  Michael Jordan | 9:05 Krishna Shenoy and Reid Harrison | 9:49 Stevenson's Law | 12:10 The Utah Array | 13:43 Neuropixels | 14:06 Dendrites by Nelson Sprusten, Greg Stuart, and Michael Häusser | 24:47 Low-power neural signal processing by Chestek Lab | 26:54 Spike sorting, Dimensionality, and Decoding | 27:30 Neural Task Complexity | 28:43 A 16-beam system that records ~1,000 neurons @ ~10 Hz | 32:16 The Braingate clinical trials | 34:15 Using Muscles as Bioelectronic Amplifiers in Peripheral Nerve Applications | 35:28 Jack Judy, University of Florida | 37:59 Touch Sensation | 38:06 DARPA HAPTIX Program | 39:22 Muscle Taco | 41:22 Janelia Research Campus | 45:59 Steliglitz Lab | 50:50 Power Consumption | 54:31 Eddie Chang and Chang Lab | 55:20 Buzsaki Paper | 55:45 BioRxiv pre-print on the Paradromics Argo System | 56:16 NeuroGrid: Recording Action Potentials from the Surface of the Brain | 1:01:30 Physical Principles for Scalable Neural Recording | 1:02:03 Pierebone lab's work with DARPA |1:04:18 Carbon Fiber Ultramicroelectrodes | 1:05:05 IMEC work with nanolaminate | 1:05:05 Picosun and Brown University |1:05:16 Stuart Cogan | 1:05:18 Michel Maharbiz | 1:07: 08 Takashi Kozai and Daryl Kipke | 1:09:44 Utah Array, Blackrock Microsystems | 1:12:29 DBS for Depression | 1:18:37 The Sewing Machine | 1:22:32 Paradromics Laser Surgical Tool | 1:22:42 Recent Papers from Schaefer and Melosh Group | 1:23:46 Tim Gardner's work on Carbon Fiber Arrays | 1:23:54 Mechanics of Microwire Penetration | 1:25:38 FDA scientists work on Accelerated Aging | Want more? Follow Paradromics & Neurotech Pub on Twitter  Follow Matt A, Tim Harris, Cindy Chestek, and Philip "Flip" Sabes on Twitter