Podcasts about mmrc

Coming up this Saturday and Sunday from 10am-4:30pm at the CN Community Centre, the MMRC is hosting their annual Model Train Show! Ron stopped by to tell us all about it.

In this episode, Dr Stephanie Martin has a discussion with Jamie Agunsday, MA, MSN, RNC-OB, a nurse abstractor for the New Jersey Maternal Mortality Review Committee. We talk about what is an MMRC, how maternal deaths are reviewed and the importance of the data that is leaned from an MMRC. She also outlines what she wants every OB healthcare provider to know about an MMRC.Jamie Agunsday is a master's prepared Registered Nurse who has spent the last decade serving women and birthing families in New Jersey. As a staff nurse in Labor and delivery in one of NJ's busiest birthing hospitals, Jamie was deeply impacted by seeing women experience serious pregnancy related complications. For the last 4 years, Jamie has worked to support the review of maternal deaths as a maternal mortality nurse abstractor where she tells the stories of those who died from complications of their pregnancies. Through all of her work, Jamie seeks to center the voices and amplify the stories of those most impacted by adverse outcomes to help make meaningful improvements in the health of all people giving birth.https://www.cdc.gov/maternal-mortality/php/data-research/mmrc-2017-2019.htmlhttps://www.cdc.gov/maternal-mortality/php/data-research/index.html#:~:text=Characteristics%20of%20Pregnancy%2DRelated%20Deaths,in%2038%20U.S.%20States%2C%202020&text=Race%20or%20ethnicity%20was%20missing,1.3%25)%20pregnancy%2Drelated%20deaths.The experts at Clinical Concepts in Obstetrics pool their decades of experience caring for critically ill pregnant women to discuss the challenges encountered in caring for these vulnerable women. Dr Stephanie Martin is the Medical Director for Clinical Concepts in Obstetrics and a Maternal Fetal Medicine specialist with expertise in critical care obstetrics. Suzanne McMurtry Baird, DNP, RN is the Nursing Director for Clinical Concepts in Obstetrics with many years of experience caring for critically ill pregnant women. Julie Arafeh, RN, MS is the Simulation Director for Clinical Concepts in Obstetrics and a leading expert in simulation.Follow us: Instagram: https://www.instagram.comDr Martin's LinkedIn: http://linkedin.com/in/stephanie-martin-65b07112aCCOB LinkedIn: https://www.linkedin.com/company/clinical-concepts-in-obstetrics/Twitter/X: https://twitter.com/OBCriticalCareCCOB Facebook: https://www.facebook.com/clinicalconceptsinobstetricsDr Martin's Facebook: https://www.facebook.com/profile.php?id=100024366859192

This episode, Dr. Danielle Tate is joined by Bethany Scalise from the TN Maternal Mortality Review Committee. Listen in as they discuss the important work the MMRC does for the state of TN and the impact this work has on maternal health. Want to learn more? Visit: https://www.tn.gov/health/health-program-areas/fhw/maternal-mortality-review.html Want to join the task force? https://stateoftennessee.formstack.com/forms/maternal_health_task_force_membership_information Question for Bethany? Email her at bethany.scalise@tn.gov No content or comments made in any TIPQC Healthy Mom Healthy Baby Podcast is intended to be comprehensive or medical advice. Neither healthcare providers nor patients should rely on TIPQC's Podcasts in determining the best practices for any particular patient.  Additionally, standards and practices in medicine change as new information and data become available and the individual medical professional should consult a variety of sources in making clinical decisions for individual patients. TIPQC undertakes no duty to update or revise any particular Podcast. It is the responsibility of the treating physician or health care professional, relying on independent experience and knowledge of the patient, to determine appropriate treatment.  

Eine sehr diverse Community trifft sich in Theatern und ähnlichen Räumen, um ihre „Balls“ abzuhalten. Diese Wettbewerbe im Vogueing sind eine Mischung aus Tanz und Performance, aber es sind auch Partys und Feste. Entstanden ist diese kulturelle Praxis in New York, als Ausdrucksform queerer Identität. Im Rahmen der jährlichen Lecture des Music and Minorities Research Center (MMRC) wurde Vogueing an der mdw zum Thema: Karin Cheng vom Kiki House of Dive trat als Performerin auf, Julia Fent vom MMRC organisierte den Rahmen. Zwischen Performance und Wissenschaft vermittelt Katrin Blantar, die von der Performance zur Forschung kam und einst als Mother eines Wiener Vogue Clubs bzw. Balls fungierte.

With about 700 pregnancy-related deaths every year, the United States has the worst maternal mortality rates among developed countries.One response to this crisis has been the creation of state and local maternal mortality review committees (MMRCs), which are multidisciplinary committees that examine the context in which maternal deaths occur.The October 2021 issue of Health Affairs is focused on the topic of perinatal mental health. MMRC reports provide a treasure trove of information that can help us understand the role perinatal mental health plays in maternal mortality and what it might take to achieve better results.Susanna Trost, an Oak Ridge Institute for Science and Education Fellow at the Centers for Disease Control and Prevention, joins Health Affairs Editor-in-Chief Alan Weil on A Health Podyssey to discuss addressing perinatal mental health as a factor in maternal mortality.Trost and co-authors published a paper in the October 2021 issue of Health Affairs analyzing data from 14 state and local MMRCs regarding pregnancy-related maternal death. Studying these determinations from 2008 to 2017, they identified the characteristics of, and factors contributing to, pregnancy-related deaths caused by mental health conditions, including substance use disorder.They found that mental health conditions are the underlying cause of nearly one-in-nine pregnancy-related deaths, all of which were considered preventable by MMRCs. This episode is sponsored by the University of Pennsylvania's Master of Health Care Innovation.If you like this interview, order the October Perinatal Mental Health Theme Issue.Subscribe: RSS | Apple Podcasts | Spotify | Stitcher | Google Podcasts

Today, Ethan talks to Sydnee from the MMRC. Follow us on instagram @uvutoday.  As always, leave us a rating and tell your friends!     Produced by Ethan Morse Music by Indigo Wave  Sound Engineering by Michael Bratsman

Today, Daniel and Ethan interview Kayla Greer from the MMRC. Follow us on instagram @uvutoday.  As always, leave us a rating and tell your friends!     Produced by Ethan Morse Music by Indigo Wave  Sound Engineering by Michael Bratsman

In this podcast Dr. Demetri Yannopoulos, a interventional cardiologist with M Health Fairview and Interventional Cardiology Researcher Director with the University of Minnesota-Twin Cities, discusses ECPR (ECMO Cardiopulmonary Resuscitation), the recent Arrest Trial and the Mobile ECMO program. Enjoy the podcast! Objectives:     Upon completion of this podcast, participants should be able to: Define the importance of time and quality of CPR on outcomes from out-of-hospital cardiac arrest (OHCA). Explain the role of ECPR and ECMO teams in the management of out-of-hospital cardiac arrest (OHCA) refractory cardiac arrest. Review the current state of the art management of cardiac arrest and the reorganization of EMS/hospital response to out-of-hospital cardiac arrest (OHCA). CME credit is only offered to Ridgeview Providers & Allied Health Staff for this podcast activity. Complete and submit the online evaluation form, after viewing the activity.  Upon successful completion of the evaluation, you will be e-mailed a certificate of completion within approximately 2 weeks.  You may contact the accredited provider with questions regarding this program at  rmccredentialing@ridgeviewmedical.org. Click on the following link for your CME credit: CME Evaluation: "ECPR (ECMO CPR): The Cardiac Resuscitation Frontier with Dr. Demetri Yannopoulos (**If you are listening to the podcasts through iTunes on your laptop or desktop, it is not possible to link directly with the CME Evaluation for unclear reasons. We are trying to remedy this. You can, however, link to the survey through the Podcasts app on your Apple and other smart devices, as well as through Spotify, Stitcher and other podcast directory apps and on your computer browser at these websites. We apologize for the inconvenience.)  DISCLOSURE ANNOUNCEMENT  The information provided through this and all Ridgeview podcasts as well as any and all accompanying files, images, videos and documents is/are for Continuing Education (CE) and other institutional learning and communication purposes only and is/are not meant to substitute for the independent medical judgment of a physician, healthcare provider or other healthcare personnel relative to diagnostic and treatment options of a specific patient's medical condition; and are property/rights of Ridgeview and Ridgeview Clinics.  Any re-reproduction of any of the materials presented would be infringement of copyright laws.  It is Ridgeview's intent that any potential conflict should be identified openly so that the listeners may form their own judgments about the presentation with the full disclosure of the facts. It is not assumed any potential conflicts will have an adverse impact on this presentation. It remains for the audience to determine whether the speaker’s outside interest may reflect a possible bias, either the exposition or the conclusions presented. Demetri Yannopoulos, MD has received honoraria from Helmsley Charitable Trust and the National Institute of Health (NIH) within the past 24 months, as a grant for research studies. Upon an independent review of his presentation, confirms he is following ACCME guidelines, and there is no commercial tie to the named agencies and no impact on his podcast presentation. Ridgeview's Continuing Education Committee members and presenter(s) have disclosed they have no significant financial relationship with a pharmaceutical company and have disclosed that no conflict of interest exists with the presentation/educational event. SHOW NOTES: Chapter 1: CPR was introduced in the 1960s. At the time, research at John Hopkins was being conducted on pigs in ventricular fibrillation and ventricular tachycardia who required defibrillation.  It was noted that when pushing defibrillation paddles against the chest wall, the arterial pressure of the subjects increased. It was concluded that with compression, pulsatile flow was generated. This was essentially the first iteration of closed chest CPR. Over the next 50 years or so, clinicians have been looking for better ways to improve survival outcomes. Key factors include early identification, early CPR, along with obtaining resources and assistance to improve ventilation, perfusion, and defibrillation. Poor predictors of survival for cardiac arrest include CPR for greater than 30 minutes and individuals with coronary artery blockage. With the integration of ECMO, it was found that by bypassing the heart and lungs and essentially taking on their functions, outcomes improved. Dr. Yannopoulos reiterates that CPR for greater than 30 minutes results in poor outcomes, thereby creating a goal to both normalize pressures during this time while also fixing the offending cause, such as a coronary artery occlusion.  Around 2015, in the Minnesota metro area, visionary EMS directors implemented an alternative option: If a patient fails three shocks, with ongoing CPR, the patient was transferred to a tertiary care facility with ECMO cannulation capabilities. Once on ECMO, these patients were transferred to the University of MN where they underwent PCI to evaluate for reversible causes such as occluded coronary vessels, PE, etc. Outcomes of this therapy showed 30-40% patient survival, which is a game changing result, thus the need for a randomized control trial, the ARREST Trial. Chapter 2: The ARREST Trial studied a group of patients with out-of-hospital cardiac arrest (OHCA) in ventricular fibrillation, refractory to defibrillation and initial ACLS treatment. This was a randomized control trial where one group was randomized to an ECMO intervention arm, versus a standard ACLS therapy arm. It was a phase 2, single center, open-label, adaptive, safety and efficacy randomized clinical trial.  Specific subject criteria included adults aged 18-75 with OHCA, refractory ventricular fibrillation, with no return of spontaneous circulation (ROSC) after three shocks, with an automated cardiopulmonary resuscitation device or LUCAS device and estimated transfer time shorter than 30 minutes. The primary outcome of the trial was survival to hospital discharge. Secondary outcomes included safety, survival and functional assessment at hospital discharge, at 3 months and 6 months after discharge. Results of the ACLS arm showed a 7% survivability, and zero at both three and six months, while the ECMO arm fared better with a 43% survivability. After enrolling 30 patients, the study was terminated at the first pre-planned interim analysis by the National Heart, Lung and Blood Institute after a unanimous recommendation from the Data Safety Monitoring Board, because the posterior probability of ECMO superiority exceeded the prespecified monitoring boundary. Cumulative 6-month survival was significantly better in the early ECMO group compared to the standard ACLS group. No unanticipated serious adverse events were observed. Conclusion: early ECMO-facilitated resuscitation for patients with OHCA and refractory ventricular fibrillation, significantly improved survival to hospital discharge compared with standard ACLS treatment. Chapter 3:  The Minnesota Mobile Resuscitation Consortium or MMRC, which was the first program to serve an entire metropolitan area in order to rapidly deliver extracorporeal membrane oxygenation (ECMO)-facilitated resuscitation to patients with refractory ventricular fibrillation/ventricular tachycardia (VF/VT) out-of-hospital cardiac arrest (OHCA). This was an observational cohort study that analyzed consecutive patients prospectively enrolled in the MMRC's ECMO-facilitated resuscitation program. Entry criteria were identical to the ARREST Trial, adults 18-75 with an out-of-hospital cardiac arrest in VF or CT with no return of spontaneous circulation post 3 shocks, use of a LUCAS or automated cardiopulmonary resuscitation device, and an estimated transfer time of less 30 minutes. The primary endpoint was functionally favorable survival to hospital discharge with Cerebral Performance Category (CPC) 1 or 2. CPC 1 results in good cerebral performance: conscious, alert, able to work, that might have some mild neuro or psych deficits. CPC 2 results in moderate cerebral disability; conscious, sufficient cerebral function for independent activities of daily living (ADLS). Secondary endpoints included 3-month functionally favorable survival. Between the period of December 1, 2019 and April 1, 2020, 63 consecutive patients were transported, and of these 58 were treated by the mobile ECMO service. Post EMCO treatment 25 of the 58 or 43% were both discharged from the hospital and alive at 3 months with CPC 1 or 2. This first, community-wide ECMO-facilitated resuscitation program in the US demonstrated 100% successful cannulation, 43% functionally favorable survival rates at hospital discharge and 3 months. Chapter 4:  As the research continues, reaching 25-30% positive outcomes would be adequate to start a viable program. Dr. Yannopoulos speculates that with overall system improvement and refined protocols, that number can be as high as 70-80%, which is an incredible number. The future of ECPR will require a combined effort of the healthcare systems, policy makers, administrators, and communities. With a successful program in the urban and suburban areas, future research can hopefully expand access to more rural populations. Dr. Yannopoulos emphasizes that this is not a hospitalized based program, it relies on the EMS system, and those providers, especially medics, are key to the success of the program. At the time of this interview, the mobile ECMO program was on hold due to COVID, but currently the mobile ECMO program has a pending restart date of March 1st. Thanks for listening.

Michele M. Rebeor is the Owner and Philanthropy Consultant at Michele M Rebeor Consulting (MMRC). MMRC specializes in helping not-for-profit organizations of all sizes enhance their current resources to build more deliberate practices that garner increases in contributions, donor loyalty, and sustainable giving. As a seasoned philanthropic and community engagement professional, Michele helps not-for-profit organizations create strategies to cultivate and build meaningful relationships with donors.  Michele has also developed niche expertise in women-focused philanthropy, applying a decade of hands-on experience in preparing, educating, and advancing organized aid organizations to effectively establish practices that recognize the significant role and substantial impact women have on the future of philanthropy. Michele also led the Arizona State University Foundation's Women and Philanthropy program. In this episode… Women have a history of being philanthropic and recent research indicates that women give more than men—and are happier when giving more.  According to Philanthropy Consultant Michele Rebeor, the data shows a massive wealth transfer where women will inherit 70% of the intergenerational wealth. What's more, these women are more likely to put that money into philanthropic endeavors. Because of this (and more), it's crucial that nonprofits and donor development professionals understand women's transformative role in philanthropic opportunities and how to engage them.  In this episode of Philanthropy212 Podcast, host Penny Cowden engages Michele M. Rebeor, Philanthropy Consultant at Michele M Rebeor Consulting (MMRC), in a conversation about engaging women in philanthropy. They delve deep into women's role in philanthropy, how dynamic it is to engage women, and strategies for engaging women donors in the right way.

Aaron, Nate & Doug make a final appeal for GOTV support in the final weekend. Amy sends us a special message to help win this race at the close of the campaign. Make sure to join the MMRC in Lexington Saturday for the big final visibility event with Mike Broihier and state Senator Reggie Thomas. 3pm at Harrodsburg Rd & Corporate Dr. Details and RSVP here: https://fb.me/e/1MpgyQq3r Join us for the news and strategy to #DitchMitch! Support our campaign! https://secure.actblue.com/donate/mmrc2020 Twitter: https://twitter.com/committeemitch Website: http://www.retirementformitch.com/ Facebook: https://www.facebook.com/MMRC2020 Instagram: http://instagram.com/mmrc2020/ Youtube: https://www.youtube.com/channel/UCRmA-EhvIxXTe3UcmCpTayA Medium: https://medium.com/@MMRC/ "Mitch, Please!" by Nato: Listen, laugh, hum, VOTE! https://www.youtube.com/watch?v=XmaqgszCYgU&t=1s Weekly live stream conversation and interview with The Mitch McConnell Retirement Committee #MoscowMitchMonday Live Mondays at 7pm Live and Post Production by www.couchfiremedia.com

Aaron Viles hosts the almost-live show solo this week, as MMRC has Labor Day off. We've got a replay of Doug Price's classic "Following Mitch's Money" deep dive on NRA cash and Russian spies, we're thrilled to talk with Kathy Hobart Spicer and Ella McCutcheon about Moms (& Students) Demand Action for Gun Sense in America and how Mitch is failing Kentucky on gun safety efforts. We've also got Congressman John Yarmuth on how Mitch is destroying our democratic norms in the Senate and sitting on gun safety legislation overwhelmingly passed by the House, and KY AFL-CIO prez Bill Londrigan schools Aaron on the state of the Labor movement. Join the Mitch McConnell Retirement Committee (MMRC), an all-volunteer group of activists from central Kentucky committed to educating Kentucky voters about how Mitch McConnell's dangerous agenda threatens our commonwealth, on our weekly podcast, #MoscowMItchMonday. The Mitch McConnell Retirement Committee #MoscowMitchMonday Support our campaign! https://secure.actblue.com/donate/mmrc2020 Facebook Live - Mondays at 7pm https://www.facebook.com/MMRC2020/live/ Facebook: https://www.facebook.com/MMRC2020/ Twitter: https://twitter.com/CommitteeMitch Instagram: http://instagram.com/mmrc2020/ Youtube: https://www.youtube.com/channel/UCRmA-EhvIxXTe3UcmCpTayA Medium: https://medium.com/@MMRC/ Website: http://retirementformitch.com/ "Mitch, Please!" by Nato: Listen, laugh, hum, VOTE! https://www.youtube.com/watch?v=XmaqgszCYgU&t=1s Live and Post Production by www.couchfiremedia.com

Former Obama speechwriter David Litt joins the MMRC to chat with Nate Orshan, Aaron Viles and Kimberly Cecil Jones about how Mitch is destroying our democracy as described in his new book, "Democracy in One Book or Less," Doug follows some dark, dark Mitch money, and Nate, Kimberly & Aaron dive into ads, forums, and the RNC as the race between #RichMitch and Amy McGrath heats up! Join the Mitch McConnell Retirement Committee (MMRC), an all-volunteer group of activists from central Kentucky committed to educating Kentucky voters about how Mitch McConnell's dangerous agenda threatens our commonwealth, on our weekly podcast, #MoscowMItchMonday. The Mitch McConnell Retirement Committee #MoscowMitchMonday Support our campaign! https://secure.actblue.com/donate/mmrc2020 Facebook Live - Mondays at 7pm https://www.facebook.com/MMRC2020/live/ Facebook: https://www.facebook.com/MMRC2020/ Twitter: https://twitter.com/CommitteeMitch Instagram: http://instagram.com/mmrc2020/ Youtube: https://www.youtube.com/channel/UCRmA-EhvIxXTe3UcmCpTayA Medium: https://medium.com/@MMRC/ Website: http://retirementformitch.com/ "Mitch, Please!" by Nato: Listen, laugh, hum, VOTE! https://www.youtube.com/watch?v=XmaqgszCYgU&t=1s Live and Post Production by www.couchfiremedia.com

Hosts Aaron Viles and Nate Orshan are joined by guest cohost, Annabel Nagel, with the Kentucky High School Democrats. MMRC's Research Director, Doug Price, connects the dots between Mitch's demand for legal protections for irresponsible corporations as a piece of any coronavirus relief package and massive corporate political contributions in this episode of "Following Mitch's Money." Finally, we interview Kentucky AFL-CIO President Bill Londrigan who details how Mitch fails Kentucky's workers. Join the Mitch McConnell Retirement Committee (MMRC), an all-volunteer group of activists from central Kentucky committed to educating Kentucky voters about how Mitch McConnell's dangerous agenda threatens our commonwealth, on our weekly podcast, #MoscowMItchMonday. The Mitch McConnell Retirement Committee #MoscowMitchMonday Support our campaign! https://secure.actblue.com/donate/mmrc2020 Facebook Live - Mondays at 7pm https://www.facebook.com/MMRC2020/live/ Facebook: https://www.facebook.com/MMRC2020/ Twitter: https://twitter.com/CommitteeMitch Instagram: http://instagram.com/mmrc2020/ Youtube: https://www.youtube.com/channel/UCRmA-EhvIxXTe3UcmCpTayA Medium: https://medium.com/@MMRC/ Website: http://retirementformitch.com/ "Mitch, Please!" by Nato: Listen, laugh, hum, VOTE! https://www.youtube.com/watch?v=XmaqgszCYgU&t=1s Live and Post Production by www.couchfiremedia.com

Join the Mitch McConnell Retirement Committee (MMRC), an all-volunteer group of activists from central Kentucky committed to educating Kentucky voters about how Mitch McConnell's dangerous agenda threatens our commonwealth, on our weekly podcast, #MoscowMItchMonday. This is a HUGE Episode, with cohosts Nate Orshan, Denise Gray & Aaron Viles joined by Congressman and Budget Committee Chairman John Yarmuth (D-KY 3), and Sandy Downs, MMRC's voter registration leader. Also, it's #NewMusicMonday with the premier of Nate Orshan's (Nato's) catchy, anti-Mitch anthem, "Mitch, Please" & as on every episode, MMRC's treasurer and research director, Doug Price follows the Kentucky Republican Party's money. The Mitch McConnell Retirement Committee #MoscowMitchMonday Support our campaign! https://secure.actblue.com/donate/mmrc2020 Facebook Live - Mondays at 7pm https://www.facebook.com/MMRC2020/live/ Facebook: https://www.facebook.com/MMRC2020/ Twitter: https://twitter.com/CommitteeMitch Instagram: http://instagram.com/mmrc2020/ Youtube: https://www.youtube.com/channel/UCRmA-EhvIxXTe3UcmCpTayA Medium: https://medium.com/@MMRC/ Website: http://retirementformitch.com/ Live and Post Production by www.couchfiremedia.com

Our Lives, Our Fortunes, and Our Sacred Honor | JULY FOURTH SPECIAL MMRC | Episode 065   Monday Morning Roll Call is released every week by On The Blue Line and provides a quick overview of issues that matter to you and provides encouragement for the week ahead.    Whiskey Coffee?! Be sure to check out our friends at campfireblend.com and use the promo code BLUELINE for 10% off your first order.   WATCH VIDEO OF THIS EPISODE ON YOUTUBE: OnTheBlueLine   In this episode I discuss: This week is an INDEPENDENCE DAY SPECIAL Two special Guests join me to celebrate the Fourth of July, to talk about freedom and to encourage all Americans to pledge to each other their Lives, their Fortunes, and their Sacred Honor. May we reclaim the principles we were founded on as a country. God Bless America!     After the episode:  Join our exclusive closed Facebook Group, On The Blue Line Guild. Join our Email List for up-to-date information, Contests, and News. Leave us an iTunes rating and review! Visit our Website regularly for the most up-to-date information. Be sure to check out our friends at campfireblend.com and use the promo code BLUELINE for 10% off your first order.   On The Blue Line was founded and is operated by active-duty law enforcement to fulfill the mission of providing guidance, resources and community for law enforcement officers, first responders, and military personal in their off-duty lives.   HONOR | EMPOWER | EDUCATE | DEFEND

I hope you are excited to go through this 10-day journey which is starting on Monday, which will cause you a lifetime transformation. Don't forget to use the hashtag #TheMillionaireMoringRoutineChallenge or #MMRC and #ojontalks so I can know you are involved and we can help others cultivate a better lifestyle. Do not forget the sequence; wake up 5:30 am WAT Meditation easy 2-3 minute work out cold shower breakfast to-do list, to-be list, Journaling. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/ojontalks/message

A new monoclonal antibody called Isatuximab is advancing through clinical trials and is getting closer to FDA approval. This antibody targets CD38. Learn more from Dr. Ravi Vij of Washington University as he discusses the findings from recent clinical trials, how this drug will be used in the clinc and how it is different from other monoclonal antibodies previously approved. Dr. Vij was the senior author on the first Isatuximab paper published in Blood and has been involved in several clinical trials to date.  Dr. Ravi Vij is Associate Professor of Medicine at the Washington School of Medicine in the Bone Marrow Transplant section. He received his medical degree in India and did follow-up training and residency at Rush-Presbyterian St. Luke’s Medical Center in Chicago and fellowships in Oncology and Bone Marrow Transplantation with Stem Cell Biology at Washington University. He’s a member of ASCO, ASH, the St. Louis Society of Clinical Oncology, and the American Association for the Advancement of Science. He serves on numerous national committees including the Myeloma, Transplant, Leukemia Committees of the Alliance for Clinical Trials in Oncology and the Steering Committee of the MMRC. His honors include the Multiple Myeloma Research Foundation Innovator Award in 2013 and the MMRC Center of Excellence Award. He’s the author of over 100 peer-reviewed publications, as well as a book called Contemporary Management of Multiple Myeloma, and several book chapters. He served as a reviewer for several journals, including Blood, Journal of Clinical Oncology, Bone Marrow Transplantation, Experimental Hematology, and Haematologica.

At the University of Michigan, Dr. Craig Cole is working on a collaboration with the MMRC to perform genomic sequencing on 500 hundred relapsed and refractory myeloma patients over a two year period. The goal is to share each patient's genomic profile to identify patient-specific treatment options. The study will be open at 11 myeloma academic centers to begin, with more to open in the future. The tissue samples collected at these centers are shipped to the University of Michigan Comprehensive Cancer Center, which then evaluates the alterations of 1700 genes. The study aims to find the specific mutations that are "actionable," or that have a drug that can be used. The study goal is to make myeloma treatment more precise for a disease that varies widely from patient to patient.  Thanks to our episode sponsor, Takeda Oncology

Hintergrund: Von den weltweit mehr als zwei Milliarden mit Würmern (griech. Helminthen) infizierten Menschen sind schätzungsweise etwa 22 Millionen zusätzlich mit HIV koinfiziert und verbleiben durch die krankheitsbedingte Produktivitäts- und Leistungsminderung in einer Abwärtsspirale. Trotz großangelegter globaler Versuche, Helminthosen mit präventiven Massenbehandlungen einzudämmen, gibt es weiterhin großen Forschungs- und Handlungsbedarf. Eine sensitivere und zuverlässigere Diagnostikmethode als die klassische Stuhlmikroskopie ist dringend erforderlich. Problemstellung und Zielsetzung: Etablierung eines molekularen Wurmdiagnostikverfahrens (Multiplex-Real- Time-Polymerase Chain Reaction) am Mbeya Medical Research Center (MMRC)-Labor im einkommensschwachen Tansania zur Detektion verschiedener Helminthen im Stuhl und direkter Vergleich mit der Merthiolat- Jod-Formalin (MIF)-Mikroskopie sowie dem derzeitigen Diagnostikgoldstandard der Kato-Katz (KK)-Mikroskopie. Klärung der Frage, ob das neue Verfahren wirklich sensitiver und für weitere Untersuchungen einsetzbar ist. Prüfung der Wirksamkeit von zur Massenbehandlung eingesetzten Medikamenten und Untersuchung von Besonderheiten bei HIV-Helminthen-koinfizierten Probanden mit Hilfe des neuen Verfahrens. Material und Methoden: Zwischen 2008 und 2011 Probensammlung, Erhebung der HI-Viruslast und CD4-Zellzahl, Stuhlmikroskopie nach der MIF- und KK-Methode, sowie Etablierung, Validierung, Durchführung und Evaluierung der Real-Time-PCR (RT-PCR) für 179 Probanden in Mbeya, Tansania. 118 Studienteilnehmer wurden nach einer Einmalgabe von 400 mg Albendazol gegen intestinale Nematoden und 40 mg/kg Praziquantel gegen Schistosomeninfektionen mit der Mikroskopie sowie der RT-PCR nachuntersucht. Zusammenfassung 108 Ergebnisse: Bei fast allen Probanden lagen laut WHO-Klassifikation leichte Infektionen vor. Eine externe sowie interne Qualitätskontrolle bestätigte die Validität unserer RT-PCR. Der Methodenvergleich ergab eine hohe Diskordanz zwischen den einzelnen Verfahren. Die RT-PCR wies 2,2 mal mehr Infektionen als MIF und 1,4 mal mehr Infektionen als KK nach. Bei etwa 17% der untersuchten Probanden lag ein Polyparasitismus vor. Mit der RT-PCR wurden mehr Mischinfektionen nachgewiesen. Ein niedriger Cycle Threshold (CT) korrelierte mit einer hohen Eizahl und umgekehrt. Die Infektionsstärke bei HIV-Wurmkoinfizierten Probanden unterschied sich nicht von der HIV-negativer Probanden. HIV-Positive schieden trotz ihrer Immunschwäche nicht weniger Schistosomeneier am Tag aus als Nichtinfizierte. Ein Polyparasitismus lag bei HIV-Positiven (37% Mischinfektionen) nicht häufiger als bei HIV-Negativen (43% Mischinfektionen) vor. Schlussfolgerung und Ausblick: Die RT-PCR erwies sich als wesentlich sensitiver als die Mikroskopie bei der Detektion von Hakenwürmern und Schistosomeninfektionen; nicht aber bei Askarideninfektionen. Als alleinig eingesetztes Diagnostikverfahren am MMRC hat sie daher keinen Bestand. Sie wird für zukünftige Studien als sensitives Zweitverfahren, das Hakenwurm-, Schistosomen- und Mischinfektionen besser nachweisen kann, neben der klassischen Kato-Katz-Mikroskopie Anwendung finden. Durch diese Arbeit konnte der Grundstein für die Diagnostik zukünftiger Studien am MMRC gelegt werden, die im Rahmen des IDEA-Projektes, einer großen afrikanisch-europäischen Forschungsinitiative, die unter anderem wurminduzierte Immunantworten in Bezug auf Koinfektionen mit HIV, Malaria und Tuberkulose und den Einfluss von Würmern auf Impfstoff-induzierte Immunantworten untersucht, durchgeführt werden. Es sollten weitere Studien zur Sensitivität der verwendeten RT-PCR-Protokolle an anderen Standorten durchgeführt werden. In Mbeya wurde das Verfahren nach meiner Abreise erfolgreich weitergeführt, sodass inzwischen fast 1000 Stühle mit der RT-PCR untersucht worden sind.

Well……. you ever wonder why Batman never let Robin fight crime on his own with just batwomen? Well if you ever did this is why. Kate and Paul do a show without Dr. John to start off the new season of MMRC with a bang… Try to enjoy.

Did you miss us? We missed you sooooo much. Now, with the Holidays out of the way, we are super excited to get back into the recap groove. This is our first (and only) recap recap. Yes, we are recapping "Guy Walks into an Advertising Agency" from season three, and this was our very first recap over 2 years ago. And in true MMRC fasion we explore the dangers of office lawn furniture, the peril of having stupid fingers and the shame of being related to Paris Hilton. Amazingly you stayed with us during this most prolonged of offseasons, and we thank you and look forward to revving the recap wagon up to full speed as season five draws near.

Back and better than ever with our take on The Arrangements, the MMRC demonstrates how to rehearse a commercial and creep out your significant other, that medals should be handed out for more than valor, and when chocolate smells like oranges your in trouble. The off season emails keep rolling in, and we love it!