Podcasts about RNC

We've now had a few weeks of a multicandidate race for the 2024 Republican presidential nomination. It's not where it eventually will be — some new candidates will undoubtedly join the race in the coming weeks and months. But there is more frequent polling than there was a few months ago, and it is possible to get an idea of the contours of the race as it stands at this moment.

Heather Digby Parton, contributing writer at Salon.com and proprietor of the blog Hullabaloo, to round up the week in news. Then, Sam and Emma are joined by Matthew Film Guy! First, Emma and Sam run through updates on Manhattan's prosecution of Donald Trump, Biden's new tax plans, the RNC teaming up with Ronny DeSantis (who privately has affirmed a 2024 presidential campaign), Santos' prolific history of scamming, a potential Saudi-Iran deal, and Manchin's possible run vs Biden in 2024. They also tackle Nikki Haley positioning herself to be Ron DeSantis' VP before Digby joins to dive deeper into this Republican rift that we see forming between Donald Trump's crazy CPAC coalition, and the Republican donor class' attempt to juxtapose Ron DeSantis' “moderate” fascism against it, looking particularly to the rhetoric about entitlements and the deficit that is coming out of the two camps. Looking forwards, Digby walks Emma and Sam through Donald Trump's likeliest routes to victory, before they wrap up the interview by tackling Joe Biden's confirmed and likely challengers in a Democratic Primary. Matthew Film Guy then joins to run his soft propaganda campaign for H. Jon Benjamin, assessing the (once again) lackluster Oscar nominations, and giving his own film suggestions of “Post Tenebras Lux” and “Margaret.” And in the Fun Half: Ed Markey goes after Norfolk Southern executives' desire to escape accountability for the disaster in East Palestine and JD Vance forgets that deregulation is actually what caused the incident. A GOP Lt. Gov faces accusations of twink love (who amongst us!) after promoting multiple homophobic bills, and Matt Taibbi gets smacked around by Democratic establishment shills because he genuinely makes it that easy. Plus, your IMs! Check out Digby's work at Salon here: https://www.salon.com/writer/heather_digby_parton Check out Hullaballoo here: http://digbysblog.net/ Check out Matthew's Letterboxd here: https://letterboxd.com/langdonboom/ Check out Matthew's film discussion group here: https://www.commonpointqueens.org/program/cultural-arts-and-jewish-heritage-classes/ Check out Matthew's eBay auction here! https://www.ebay.com/itm/115464749223 Check out "Bill Lee Is A Drag" here: https://www.billleeisadrag.com/ Become a member at JoinTheMajorityReport.com: https://fans.fm/majority/join Subscribe to the ESVN YouTube channel here: https://www.youtube.com/esvnshow Subscribe to the AMQuickie newsletter here: https://am-quickie.ghost.io/ Join the Majority Report Discord! http://majoritydiscord.com/ Get all your MR merch at our store: https://shop.majorityreportradio.com/ Get the free Majority Report App!: http://majority.fm/app Check out today's sponsors: Sunset Lake CBD: Sunset Lake CBD is introducing its newest topical product: Extra Strength Muscle Rub. All CBD topicals— salves, lotion, and the new muscle rub— are 25% off. Use code EXTRA at checkout. sunsetlakecbd is a majority employee owned farm in Vermont, producing 100% pesticide free CBD products. Great company, great product and fans of the show! Also, use code Leftisbest and get 20% off at http://www.sunsetlakecbd.com. Aura: Go to my sponsor https://aura.com/majority to try 14 days free and let Aura go to work protecting your private information online Follow the Majority Report crew on Twitter: @SamSeder @EmmaVigeland @MattBinder @MattLech @BF1nn @BradKAlsop Check out Matt's show, Left Reckoning, on Youtube, and subscribe on Patreon! https://www.patreon.com/leftreckoning Subscribe to Discourse Blog, a newsletter and website for progressive essays and related fun partly run by AM Quickie writer Jack Crosbie. https://discourseblog.com/ Check out Ava Raiza's music here! https://avaraiza.bandcamp.com/ The Majority Report with Sam Seder - https://majorityreportradio.com/

Jennifer Coleman, MSN, RNC is a labor & delivery postpartum NICU nurse, college professor and Certified Health Coach. Jen and I discuss her past struggles battling self image and her self-described "unhealthy relationship with food." Jen discusses how she turned her life around, her mission to live a healthy life and how she is helping hundreds of other people do the same.Connect with Jennifer Coleman, MSN, RNC, & Certified Health Coach:Facebook: Jennifer Coleman, MSN, RNC Email: jencoleman27@yahoo.com"Life is Built, Not Born."Joe Ciccarone

Veteran foreign-policy expert Ed Haugland joined the Two Mikes today to discuss a new organization that intends to mobilize public opinion against Biden's Administration and the domestic worldwide Deep State.With a bit more than 18 months until the next national election, the new organization -- "Citizens' Commission to Restore America" (CCRA) -- will work to make American citizens (1) much more aware of the most important issues which they must understand and defeat; to provide materials that will empower citizens to take political actions to rid the country of the lethal threats it faces; and (3) motivate citizens to take simple but impactful actions by going to CCRA websites (see below) printing letters that are addressed to multiple U.S. politicians, political candidates, the RNC and DNC, leading citizens, policymakers; read them, and, if the downloader concurs with its content, sign and mail them to the addressed recipients.For the cost of a postage stamp, the CCRA believes that the American citizenry can establish a constant and growing bombardment of the country's bipartisan governing elite with informed dissent and pointed opposition to Biden's quickly growing domestic tyranny, as well as the illegal and unconstitutional diktats of the New World Order, the WEF, and the UN.Time is growing short to save the republic, and Mr. Haugland today explained the full CCRA program of resistance in this lengthy episode. Both of us urge our listeners to listen to all of the podcast and give the CCRA program a thorough examination at the websites listed below.--Ed Haugland's website: https://www.informationequilibrium.blogspot.org--The CCRA website is under construction however, you can get the information on our WEBSITE wwwTwoMikes.US IN OUR BLOG POSTS SECTION “Listening to Two Mikes will make you smarter!” - Gov Robert L. Ehrlich, JrSponsorsCARES Act Stimulus (COVID-19) Employee Retention Tax Credits (ERC): https://www.jornscpa.com/snap/?refid=11454757 Cambridge Credit: https://www.cambridge-credit.org/twomikes/ EMP Shield: https://www.empshield.com/?coupon=twomikes Our Gold Guy: https://www.ourgoldguy.com www.TwoMikes.us

Presidential primary voters will cast their first ballots in less than a year. As the field begins to take shape and pressure mounts, divisions within the GOP are becoming clearer. Doug Heye, former communications director to House Majority Leader Eric Cantor and the RNC, and David Avella, chair of GOPAC, a Republican Super PAC that trains and assists candidates, join Amna Nawaz to discuss. PBS NewsHour is supported by - https://www.pbs.org/newshour/about/funders

Happy Fri-yay! Steve is joined in studio by democratic strategist, Joe Zepecki, and over the phone by Bill McCoshen! The trio tackle the latest political issues, the supreme court race & get in their grab bags! Plus, banning Tik-Tok - Good or bad idea? And, extended bar hours for the RNC? Tune in!

Department of Energy says it's likely covid leaked from Wuhan lab. Crisis of confidence in government, which lied, covered up and got everything wrong on covid. Woody Harrelson punctures SNL propaganda veil, blasts drug company "cartel" on vaccines. DeSantis beats Disney, signs bill, takes over Disney district. RNC chair says all debate participants must sign pledge not to run third party.Follow Clay & Buck on YouTube: https://www.youtube.com/c/clayandbuckSee omnystudio.com/listener for privacy information.

MSNBC's Ari Melber hosts "The Beat" on Tuesday, February 28, and reports on Dominion's $1.6 billion defamation suit against Fox News, GOP censorship, and Steve Bannon's latest court appearance. Emily Bazelon, Rick Wilson, and Chai Komanduri join.

In conversation with the Racine Dominicans, the Nuns discuss DIY scapulars, Purgatory, and indulgences. Read the transcript here: https://anunslife.org/podcasts/random-nun-clips/RNC-as068-blessing-scapular Hear the full Ask Sister episode at https://anunslife.org/podcasts/ask-sister/as068-ask-sister Don't forget to call us and leave a message. Tell us what you like, ask a question, or just say hi. Call 913-214-6087. Let us know your thoughts about the podcast by taking this short survey! Your input helps us shape the future of the Ask Sister podcast! Click HERE to take the survey. Thank you!

RNC chair Ronna McDaniel stated Sunday that Republican presidential hopefuls must support the eventual nominee to debate on the RNC stage. McDaniel says candidates must sign the commitment before the first primary debate in Milwaukee. But, former President Trump opposes the vow, citing his 2016 reluctance.

Air raid sirens rang through the Ukrainian night as Russia lobbed artillery, drones and missiles in every corner of the country. That as the United States delivered a public warning to China: Don't dispatch weapons to Vladimir Putin.  Plus: The chairwoman of the RNC thinks she can get Donald Trump to put pen to paper and say yes to supporting the party's 2024 nominee, even if it's not him.  And: New intelligence pushes the Energy Department to change its view of how the Covid pandemic began. The agency now believes the virus leaked from a Chinese lab. To learn more about how CNN protects listener privacy, visit cnn.com/privacy

Paul Ryan, a former House Speaker, has announced that if former President Donald Trump wins the party's nomination, he will not attend the Republican National Convention in 2024. Ryan is already campaigning for the nominee to be anyone "not called Trump" even though the RNC has set the location of the Republican convention to be in his home state of Wisconsin. Where will you be for the GOP convention in Milwaukee? inquired an ABC 12 reporter. Ryan answered, "It depends on who the candidate is. "If it's someone who isn't named Trump, I'll be here."

Department of Energy says it's likely covid leaked from Wuhan lab. Crisis of confidence in government, which lied, covered up and got everything wrong on covid. Woody Harrelson punctures SNL propaganda veil, blasts drug company "cartel" on vaccines. DeSantis beats Disney, signs bill, takes over Disney district. RNC chair says all debate participants must sign pledge not to run third party.Follow Clay & Buck on YouTube: https://www.youtube.com/c/clayandbuckSee omnystudio.com/listener for privacy information.

A listener is puzzled why gluttony is included among “the seven deadly sins.” The Nuns discuss! Read the transcript here: https://anunslife.org/podcasts/random-nun-clips/RNC-as238-why-is-gluttony-a-sin Listen to the full Ask Sister podcast here: https://anunslife.org/podcasts/ask-sister/as238 Don't forget to call us and leave a message. Tell us what you like, ask a question, or just say hi. Call 913-214-6087. Let us know your thoughts about the podcast by taking this short survey! Your input helps us shape the future of the In Good Faith podcast! Click HERE to take the survey. Thank you!

This week the Hacks were joined by Hackeroo (and very friendly guy) Doug Heye. Doug taps into his experience as the former communications director for the RNC and deputy chief of staff to Eric Cantor to discuss the 2024 primary field, Biden's recent trip to Ukraine, and how age will factor into both Biden and Trump's next steps. The Hacks also dive into the Midwest and look at a Wisconsin Supreme Court Race and the Chicago Mayor's race.

In conversation with Sister Mary Jane Hahner, CSFN, and students from the University of Notre Dame, the Nuns discuss ideas of what to do for Lent. Read the transcript here: https://anunslife.org/podcasts/random-nun-clips/RNC-as062-what-can-you-do-for-Lent Hear the full Ask Sister episode at https://anunslife.org/podcasts/ask-sister/as062-ask-sister Don't forget to call us and leave a message. Tell us what you like, ask a question, or just say hi. Call 913-214-6087. Let us know your thoughts about the podcast by taking this short survey! Your input helps us shape the future of the Ask Sister podcast!

This week on Breaking Battlegrounds, we are honored to be joined by former Congresswoman Mia Love of Utah and current Senator Marco Rubio of Florida. We also check in with our friend Alexander Raikin for an update on Canada's assisted suicide program. -Mia B. Love is a former Representative of the 4th Congressional District of Utah. Love was elected to office in 2014. She is the first and only Republican black female to ever serve in The United States Congress. Love was appointed as the only freshman to serve on the Select Panel for Infant Lives, to investigate the selling of organs on the free market. She was also selected to serve on the Financial Services Committee (which handles regulation of our nation's financial institutions) Terrorism and Illicit Finance, Financial Institutions and Monetary Policy and Trade subcommittees.While in office, she was a champion for reducing burdensome regulations and sponsoring legislation that make it easier for small and community banks to lend money to individuals and families. That bill (part of S. 2155) was signed into law in August of 2018. Rep. Love was also a leader in the push for immigration reform, and adamantly works to protect life at all stages of development, liberty and the pursuit of happiness for all. She was awarded the Marilyn Musgrave "Defender of Life Award" for her work in protecting life in Congress.Rep Love was a headline speaker at the 2012 RNC convention in Tampa FL. Prior to her work in Congress, Rep. Love served as a city councilwoman and mayor in her hometown of Saratoga Springs, Utah.Mia is currently a CNN correspondent and was recently appointed as a non-resident senior fellow at The United States Studies Centre at the University of Sydney.Mia is passionate about getting Americans out of government poverty programs that are meant to trap and destroy families and promoting free market principles. She has advocated for limited government, fiscal discipline and personal responsibility.Mia is currently a CNN correspondent and was recently appointed as a non-resident senior fellow at The United States Studies Centre at the University of Sydney. Most importantly, Mia is the daughter of legal immigrants from Haiti, a wife, a mother of three children and a proud American.-Marco Rubio has represented Florida in the United States Senate since 2010, where he has one guiding objective: bring the American Dream back into the reach of those who feel it slipping away.Senator Rubio's efforts have been successful and long-lasting. Non-partisan analyses by GovTrack and the Center for Effective Lawmaking ranked Rubio the Senate's number two leader and most effective Republican in 2020.Senator Rubio currently serves as Vice Chairman of the Senate Select Committee on Intelligence, where he oversees our nation's intelligence and national security apparatus. Senator Rubio is also a member of the Foreign Relations Committee, where he fights to promote human rights and America's interests around the globe; the powerful Appropriations Committee, which allocates funding for the federal government; and the Special Committee on Aging, dedicated to the needs of older Americans.In addition, Senator Rubio serves on the Committee on Small Business and Entrepreneurship, where works to help small businesses thrive in the 21st century. As former Chairman of this committee, Rubio authored the historic Paycheck Protection Program, which has been a lifeline to millions of small businesses and Americans workers as they battle economic hardship in the wake of the COVID-19 pandemic.Senator Rubio was born in Miami, after his parents came to the United States from Cuba in search of the American Dream. He lives there today with his wife Jeanette and their four children.-Alexander Raikin is a freelance journalist and a writer interested in medical ethics and bad statistics. His writings have been published in City Journal and The New Atlantis. Alexander is also a research fellow with Do No Harm. He can be found on Twitter at @AlexanderRaikin -Connect with us:www.breakingbattlegrounds.voteTwitter: www.twitter.com/Breaking_BattleFacebook: www.facebook.com/breakingbattlegroundsInstagram: www.instagram.com/breakingbattlegroundsLinkedIn: www.linkedin.com/company/breakingbattlegrounds This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit breakingbattlegrounds.substack.com

In today's episode:Tucker Carlson asks the right questionDominion claims Fox News hosts "knew" the elections weren't stolen, which doesn't matterA Georgia grand jury comes up empty in their Trump investigationCaptain Keshel on Georgia cities reclaiming power over electionsThe RNC says no to Ranked Choice VotingThe AZ legislature works to end voting machinesKari Lake looks toward the AZ Supreme Court.Connect with Be Reasonable: https://linktr.ee/imyourmoderatorHear the show when it's released. Become a paid subscriber at imyourmoderator.substack.comOther ways to support the work:ko-fi.com/imyourmoderatorbtc via coinbase: 3MEh9J5sRvMfkWd4EWczrFr1iP3DBMcKk5Merch site: https://cancelcouture.myspreadshop.com/Follow the podcast info stream: t.me/imyourmoderatorOther social platforms: Twitter, Truth Social, Gab, Rumble, or Gettr - @imyourmoderator Become a member at https://plus.acast.com/s/be-reasonable-with-your-moderator-chris-paul. Hosted on Acast. See acast.com/privacy for more information.

OSN #50A | THE RNC CAUGHT PLOTTING AGAINST TRUMP! [OPEN SOURCE NEWS. 19 FEB 23. MIDNIGHT SHOW] #BCPTODAY #TRUMP #RNC #MIKEPENCE 00:00 Did you even know this just happened?? 04:49 A big win for FREE SPEECH in an unlikely place with an unlikely player 10:23 Tinfoil hat fears ring true after all 17:29 Latest Ohio disaster aftermath 20:30 RNC's latest move against TRUMP 23:04 Mike Pence NOTHINGBURGER 24:12 U.S. foreign relations news 28:59 Democrats are liars and killers 3 Ways to watch my other show, BCP UNFILTERED: www.TheRealBCP.com www.BCPextras.com www.BCPpodcast.com Subscribe to our sister YouTube channel, The BCP REPORT: https://bit.ly/3BFyKhB Social Media: FaceBook: https://bit.ly/40Ayz3a Truth Social: @BCPtv Locals: @TheRealBCP GETTR: @Black_C_Patriot gab: @Black_Conservative

In today's episode:Tucker Carlson asks the right questionDominion claims Fox News hosts "knew" the elections weren't stolen, which doesn't matterA Georgia grand jury comes up empty in their Trump investigationCaptain Keshel on Georgia cities reclaiming power over electionsThe RNC says no to Ranked Choice VotingThe AZ legislature works to end voting machinesKari Lake looks toward the AZ Supreme Court.Connect with Be Reasonable: https://linktr.ee/imyourmoderatorHear the show when it's released. Become a paid subscriber at imyourmoderator.substack.comOther ways to support the work:ko-fi.com/imyourmoderatorbtc via coinbase: 3MEh9J5sRvMfkWd4EWczrFr1iP3DBMcKk5Merch site: https://cancelcouture.myspreadshop.com/Follow the podcast info stream: t.me/imyourmoderatorOther social platforms: Twitter, Truth Social, Gab, Rumble, or Gettr - @imyourmoderator Become a member at https://plus.acast.com/s/be-reasonable-with-your-moderator-chris-paul. Hosted on Acast. See acast.com/privacy for more information.

How long is the celebration of Mardi Gras? What exactly does it celebrate? For Lent, is it better to give something up, or take something up? The Nuns discuss! Read the transcript here: https://anunslife.org/podcasts/random-nun-clips/RNC-mardi-gras-lent Don't forget to call us and leave a message. Tell us what you like, ask a question, or just say hi. Call 913-214-6087. Let us know your thoughts about the podcast by taking this short survey! Your input helps us shape the future of the In Good Faith podcast! Click HERE to take the survey. Thank you!

This month on Episode 45 of Discover CircRes, host Cynthia St. Hilaire highlights four original research articles featured in the February 3rd and February 17th issues of Circulation Research. This episode also features an interview with Dr Hind Lal and Dr Tousif Sultan from the University of Alabama at Birmingham about their study Ponatinib Drives Cardiotoxicity by S100A8/A9-NLRP3-IL-1β Mediated Inflammation.   Article highlights:   Pi, et al. Metabolomic Signatures in PAH   Carnevale, et al. Thrombosis TLR4-Mediated in SARS-CoV-2 Infection   Cai, et al. Macrophage ADAR1 in AAA   Koide, et al. sEVs Accelerate Vascular Calcification in CKD   Cindy St. Hilaire:        Hi, and welcome to Discover CircRes, the podcast of the American Heart Association's journal, Circulation Research. I'm your host, Dr Cynthia St. Hilaire from the Vascular Medicine Institute at the University of Pittsburgh, and today I'm going to be highlighting the articles from our February 3rd and 17th issues of Circulation Research. I'm also going to have a chat with Dr Hind Lal and Dr Tousif Sultan from the University of Alabama at Birmingham about their study, Ponatinib Drives Cardiotoxicity by S100A8/A9-NLRP3-IL-1β Mediated Inflammation. But before I get to the interviews, here are a few article highlights.   Cindy St. Hilaire:        The first article I want to highlight comes from the laboratory of Dr Peter Leary at the University of Washington, and the title is Metabolomic Signatures Associated With Pulmonary Arterial Hypertension Outcomes. Pulmonary Arterial Hypertension or PAH is a rare but life-threatening disease in which progressive thickening of the walls of the lung's blood vessels causes increased blood pressure and that increased blood pressure ultimately damages the heart's right ventricle.   Interestingly, progression to heart failure varies considerably among patients, but the reasons why there is variability are not well understood. To find out, this group turned their attention to patient metabolomes, which differ significantly from those of healthy people and thus may also change with severity. Blood samples from 117 PAH patients were analyzed for more than a thousand metabolites by mass spectrometry and the patient's progress was followed for the next three years. 22 patients died within a three-year period and 27 developed significant right ventricle dilation. Other measures of severity included pulmonary vascular resistance, exercise capacity and levels of BNP, which is a metric of heart health. Two metabolic pathways, those relating to polyamine and histidine metabolism, were found to be linked with all measures of severity suggesting a key role for them in disease pathology. While determining how these pathways influence disease as a subject for further study, the current findings may nevertheless lead to new prognostic indicators to inform patient care.   Cindy St. Hilaire:        The next article I want to discuss is coming from our February 3rd issue of Circulation Research and this is coming from the laboratory of Dr Francisco Violi at the University of Rome and the title is Toll-Like Receptor 4-Dependent Platelet-Related Thrombosis in SARS-CoV-2 Infection. Thrombosis can be a complication of COVID-19 and it is associated with poor outcomes, including death. However, the exact mechanism by which the virus activates platelets, which are the cells that drive thrombosis, is not clear. For one thing, platelets do not appear to express the receptor for SARS-CoV-2. They do however, express the TLR4 receptor and that's a receptor that mediates entry of other viruses as part of the immune response. And TLR4 is ramped up in COVID-19 patient platelets. This group now confirms that, indeed, SARS-CoV-2 interacts with TLR4, which in turn triggers thrombosis.   The team analyzed platelets from 25 patients and 10 healthy controls and they found that the platelet activation and thrombic activity were both boosted in the patient samples and could not be blocked using a TLR4 inhibitor. Additionally, immunoprecipitation and immunofluorescent experiments further revealed colocalization between the virus protein and the TLR4 receptor on patient platelets. The team went on to show that the signaling pathway involved reactive oxygen species producing factors p47phox and Nox2, and that inhibition of phox 47, like that of the TLR4 receptor itsel,f could prevent platelet activation. As such, this study suggests that inhibiting either of these proteins may form the basis of an antithrombotic treatment for COVID-19.   Cindy St. Hilaire:        The third article I want to highlight is coming from the lab of Shi-You Chen at University of Missouri and the title of this article is ADAR1 Non-Editing Function in Macrophage Activation and Abdominal Aortic Aneurysm. Macrophage activation plays a critical role in abdominal aortic aneurysm development, or AAA development. Inflammation is a component of this pathology; however, the mechanisms controlling macrophage activation and vascular inflammation in AAA are largely unknown. The ADAR1 enzyme catalyzes the conversion of adenosine to inosine in RNA molecules and thus this conversion can serve as a rheostat to regulate RNA structure or the gene coding sequence of proteins. Several studies have explored the role of ADAR1 in inflammation, but its precise contribution is not fully understood, so the objective of this group was to study the role of ADAR1 in macrophage activation and AAA formation.   Aortic transplantation was conducted to determine the importance of nonvascular ADAR1 in AAA development and dissection and angiotensin II infusion of ApoE knockout mice combined with a macrophage specific knockout of ADAR1 was used to study the role of ADAR1 macrophage specific contributions to AAA formation and dissection. Allograft transplantation of wild type abdominal aortas to ADAR1 haploinsufficient recipient mice significantly attenuated AAA formation. ADAR1 deficiency in hematopoietic stem cells also decreased the prevalence and the severity of AAA and it also inhibited macrophage infiltration into the aortic wall. ADAR1 deletion blocked the classic macrophage activation pathway. It diminished NF-κB signaling and it enhanced the expression of a number of anti-inflammatory microRNAs. Reconstitution of ADAR1 deficient but not wild type human monocytes to immunodeficient mice blocked the aneurysm formation in transplanted human arteries. Together these results suggest that macrophage ADAR1 promotes aneurysm formation in both mouse and human arteries through a novel mechanism of editing the microRNAs that target NF-κB signaling, which ultimately promotes vascular inflammation in AAA.     Cindy St. Hilaire:        The last article I want to highlight is also from our February 17th issue of Circulation Research and it is coming from the lab of Shintaro Mandai at Tokyo Medical and Dental University and the title of the article is Circulating Extracellular Vesicle Propagated MicroRNA signatures as a Vascular Calcification Factor in Chronic Kidney Disease. Chronic Kidney Disease or CKD accelerates vascular calcification in part by promoting the phenotypic switching of vascular smooth muscle cells to osteoblast like cells. This study investigated the role of circulating small extracellular vesicles or SUVs from the kidneys in promoting this osteogenic switch. CKD was induced in rats and in mice by an adenine induced tubular interstitial fibrosis and serum from these animals induced calcification in in vitro cultures of A-10 embryonic rat smooth muscle cells. Intraperitoneal administration of a compound that prevents SEV biosynthesis and release inhibited thoracic aortic calcification in CKD mice under a high phosphorus diet. In Chronic Kidney Disease, the microRNA transcriptome of SUVs revealed a depletion of four microRNAs and the expression of the microRNAs inversely correlated with kidney function in CKD patients.   In vitro studies found that transected microRNA mimics prevented smooth muscle cell calcification in vitro. In silico analyses revealed that VEGF-A was a convergent target of all four microRNAs and leveraging this, the group used in vitro and in vivo models of calcification to show the inhibition of the VEGF-A, VEGFR-2 signaling pathway mitigated calcification. So in addition to identifying a new potential therapeutic target, these SUV propagated microRNAs are a potential biomarker that can be used for screening patients to determine the severity of CKD and possibly even vascular calcification.   Cindy St. Hilaire:        Today I have with me Dr Hind Lal who's an associate professor of medicine at the University of Alabama Birmingham and his post-doctoral fellow and the lead author of the study Dr Tousif Sultan. And their manuscript is titled Ponatinib Drives Cardiotoxicity by S100A8/A9-NLRP3-IL-1β Mediated Inflammation. And this article is in our February 3rd issue of Circulation Research. So thank you both so much for joining me today.   Tousif Sultan:              Thank you.   Hind Lal:                     Thank you for taking time.   Cindy St. Hilaire:        So ponatinib, it's a tyrosine kinase inhibitor and from my understanding it's the only treatment option for a specific group of patients who have chronic myelogenous leukemia and they have to harbor a specific mutation. And while this drug helps to keep these patients alive essentially, it's extremely cardiotoxic. So cardiotoxicity is somewhat of a new field. So Dr Lal, I was wondering how did you get into this line of research?    Hind Lal:                    So I was fortunate enough to be in the lab of Dr Tom Force and he was kind of father of this new area, now is very developed, it's called cardio-oncology. On those days there were basically everything started in cardio-oncology. So I just recall the first tyrosine kinase approved by FDA was in 2000 and that was... Imagine and our paper came in Nature Medicine 2005 and discovering there is... so to elaborate it a little bit, the cancer therapy broadly divided in two parts. One is called non-targeted therapy like chemotherapy, radiations, et cetera, and then there are cytotoxic drugs. So those cytotoxic drugs because they do not have any targeted name on it so they are, cardiotoxic are toxic to any organ was very obvious and understanding. When these targeted therapy came, which is mainly kinase inhibitor are monoclonal antibodies. So these are targeted to a specific pathway that is activated only in the cancer cells but not in any other cells in the body so they were proposed as like magic bullets that can take off the cancer without any cardiotoxity or minimal side effects. But even in the early phase like 2005 to 2010, these came out, these so-called targeted, they are not very targeted and they are not also the magic bullets and they have serious cardiotoxicity.   Cindy St. Hilaire:        And so what's the mechanism of action of ponatinib in the leukemia and how does that intersect with the cardiovascular system?   Hind Lal:                     Yeah, so this is very good question I must say. So what we believe at this point because, so leukemia if you know is driven by the famous Philadelphia chromosome, which is a translicational gene, one part of human chromosome nine and one part of human chromosome 22 and they translocate make a new gene which is BCR-ABL gene. And because it was discovered in Philadelphia UPENN, is named that Philadelphia chromosome, which is very established mechanism, that's how CML is driven. But what we have discovered that the cardiotoxicity driven by totally, totally different from the ponatinib is one of the inflammatory So it's kind of goodening. So this question is so good. One kind of toxicity is called on-target, when toxicity is mediated by the same mechanism, what is the mechanism of the drug to cure the cancer? So in that case your absolute is minimal because if you manipulate that, the drug's ability to cure the cancer will be affected but if the toxicity and the efficacy is driven by two different mechanism, then as in case of ponatinib seems like it's NLRP3 and inflammasome related mechanism. So this can be managed by manipulating this pathway without hampering the drug efficacy on the cancer.   Cindy St. Hilaire:        So what exactly is cardiotoxicity and how does it present itself in these patients?   Hind Lal:                     So these drugs like ponatinib, they call broader CVD effects. So it's not just cardiac, so they also in hypertensives and atherosclerosis and thrombosis, those kind of thing. But our lab is primarily focused on the heart. So that's why in this paper we have given impresses on the heart. So what we believe at this point that ponatinib lead to this proinflammatory pathway described in this paper, which is just 108A9-NLRP3-IL-1β and this inflammatory pathway lead to a cytokine storm very much like in the COVID-19 and these cytokine storms lead to excessive myocarditis and then finally cardiac dysfunction.   Cindy St. Hilaire:        Is the cytokine storm just local in the cardiac tissue or is it also systemic in the patients? Is cardiotoxicity localized only or is it a more systemic problem?   Tousif Sultan:              I would like to add in this paper we have included that we look this cytokine things and explain blood circulation, bone marrow. So the effect is everywhere, it's not local. So we didn't check other organs, maybe other organs also being affected with the ponatinib treatment.   Cindy St. Hilaire:        And what's the initial phenotype of a patient has when they start to get cardiotoxicity, what's kind of like a telltale symptom?   Hind Lal:                     So good thing that in recent years cardio-oncology developed. So initially the patient that were going for cancer treatment, they were not monitored very closely. So they only end up in cardiology clinic when they are having some cardiac events already. So thanks to the lot of development and growth in the cardio-oncology field, now most patients who going for a long-term cancer treatment, they are closely monitored by cardiology clinics.   Cindy St. Hilaire:        Got it. So they can often catch it before a symptom or an event. That's wonderful.   Hind Lal:                     Yeah, so there's a lot of development in monitoring.   Cindy St. Hilaire:        Wonderful. So you were really interested in figuring out why ponatinib induces cardiotoxicity and you mentioned that really up until now it's been very difficult to study and that's because of the limitation of available murine models. If you just inject a wild type mouse with ponatinib, nothing happens really. So what was your approach to finding relatively good murine models? How did you go about that?   Hind Lal:                     So this is the top scientific question you can ask. So like science, the field is try and try again. So initially this is the first paper with the ponatinib toxicity using the real in vivo models. Any paper before this including ours studies published, they were done on the cellular model in hiPSC, that isolated cardiomyocytes. So you directly putting the ponatinib directly the isolated cells. So this is first case when we were trying to do in vivo, maybe other attempt in vivo but at least not published. So first we also treated the animals with ponatinib and that failed, we don't see any cardiotoxic effect. And then when we going back to the literature, the clinical data is very, very clear from pharmacovigilance that ponatinib is cardiotoxic in humans. So when we're not able to see any phenotype in mouse, we realize that we are not mimicking what's happening in the humans.   So we certainly missing something. Now once again I quote this COVID-19, so many people get infected with COVID-19 but people are having preexisting conditions are on high risk to developing CVD. So there was some literature on that line. So we use this very, very same concept that if there is preexisting conditions, so likely who'd have developing future cardiac event will be more. So we use two model in this paper one atherosclerosis model which is APoE null mice mice, another is tag branding which is pressure overload model for the heart and as soon as we start using what we call comorbidity model like patient is having some preexisting conditions and we very clearly see the robust defect of ponatinib on cardiac dysfunction.   Cindy St. Hilaire:        Yeah, it's really, really well done and I really like that you use kind of two different models of this. Do you think it's also going to be operative in maybe like the diabetic mirroring models? Do you think if we expand to other comorbidities, you might also recapitulate the cardiotoxicity?   Hind Lal:                     So you got all the best questions.   Cindy St. Hilaire:        Thank you. I try.   Hind Lal:                     So because this is CML drug and lot of the risk factor for cardiovascular and cancer are common and even metabolic disease. So most of the time these patients are elderly patients and they're having metabolic conditions and most of the time they have blood pressure or something CVD risk factors. So I agree with you, it'll be very relevant to expand this to the diabetes or metabolic models, but these were the first study, we put all our focus to get this one out so news is there then we can expand the field adding additional models et cetera. But I agree with you that will be very logical next step to do.   Cindy St. Hilaire:        Yeah. And so I guess going back to what you know from the human study or the clinical trials or the human observations, are different populations of patients with CML more predisposed to cardio toxicity than others or is that not known yet?   Hind Lal:                     So one other area called pharmacovigilance. So what pharmacovigilance does patient all over the world taking these drugs. So WHO have their own vigilance system and FDA have their own, so it's called BG-Base for the WHO and it's called the FAERS for the FDA. So one can go back in those data sets and see if X patient taking this Y drug and what kind of symptoms or adverse effect they are seeing and if these symptoms are associated with something else. So there is data that if patients having CVD risk factor, they are more prone to develop ponatinib induced cardiac events. But it needs more polish like you asked the just previous question, diabetes versus maybe blood pressure means hypertension, atherosclerosis, or thrombosis. So it has not been delineated further but in a one big bucket if patients are having CVD risk factor before they are more prone and more likely to develop the cardiac events.   Cindy St. Hilaire:        So after you established that these two murine models could pretty robustly recapitulate the human phenotype, what did you do next? How did you come upon the S100A8/A9-NLRP3-IL-1β signaling circuit? How did you get to that?   Hind Lal:                     So in basic science work, whenever we do mouse is called until we get there is cardiac dysfunction, it's called phenotype, right? So mouse had a cardiac phenotype. So next step is, "Why? What is leading to that phenotype?" That's what we call mechanism. So there the best idea to fit the mechanism is using one of the unbiased approaches like you do unbiased proteomics, unbiased RNC analysis, something like this that will analyze the entire transcript like RNC and say, "Okay, these pathway are," then you can do further analysis that will indicate these pathway are different, are altered. So in this case we used RNC analysis and it came out that this yes A8 and yes A9, 100A8 and nine, they were the most upregulated in this whole set. And thereafter we were very lucky. So we started this study at Vanderbilt, where my lab was and thereafter we very lucky to move here and found Sultan who had a lot of experience with this inflammation and immune system and then Sultan may add something on this so he'll be the better person to say something on this.   Tousif Sultan:              So after our RNC analysis, so we got this S100A8 and nine as top hit with the ponatinib treatment. So then we validated this finding with our flow cytometric, qRT PCR aand then we started which pathway is going to release cytokine and all that. So we found that is NLRP3 inflammasome.   Cindy St. Hilaire:        Yeah and well and I guess maybe step back, what is S100A8/A9? What are those? Tousif Sultan:              Yeah, S10A8/A9 is a calcium binding protein. So that's also called alarmin and they basically binds with the pathogen associated pattern and other TLR2 like receptors and then start inflammatory pathway to release cytokine and all that and it's stable in heterodimer form. So S100A8 heterodimer with A9 and then bind with TLR and a start in this inflammatory pathway.   Cindy St. Hilaire:        And what type of cell is that happening in? Is that happening in the immune cells only or is it also in the cardiomyocyte, or...?   Tousif Sultan:              Yeah, we have included all this data. So from where this alarmin is coming with ponatinib treatment, so literature also suggested that neutrophils and monocytes, those cells are the potential to release the alarmin. So here we also found these two type of cells, neutrophils and monocytes. They release huge alarmin with the treatment of ponatinib.   Cindy St. Hilaire:        And so really taking this really neat mechanism to the next level, you then tried attenuating it by using broad anti-inflammatory steroid dexamethasone but also by targeting these specific components, the NLRP and the S100A specific inhibitors and they worked well. It worked really nicely. Does your data show that any of these therapies work better than the other and then are these viable options to use in humans?   Hind Lal:                     Yeah, we have some data in the paper. Are very broad which help a lot in COVID patients, far very acute infections. So in this case, situation is very different cause most of CML patients will going to take ponatinib for lifelong, there is no remission, right? So in those case, its certainly not a very attractive option. We have shown data in the paper that dexamethasone help with the heart but lead to some metabolic changes. So we have compared those with the NLRP3 inhibitors, those metabolic alterations, dexa versus the NLRP3 inhibitors, CY-09. And we demonstrated that targeting is specifically with paquinimod, our NLRP3 inhibitor CY-09, feel better. It can still rescue the cardiac phenotype without having those adverse effect on metabolic parameters.   Cindy St. Hilaire:        That's wonderful. Do you think though that because you have to take ponatinib for life, that long-term NLRP inhibition would also cause problems or...?   Hind Lal:                     So because not every patient who taking ponatinib would develop the cardiac phenotype, right? Which is like a 10%, 12%, patient developing cardiac dysfunction. So I think someone like I strongly believe paquinimod, which is inhibitor of S100A9, will be really good option or at least we have enough data that make us nail for at least a small clinical trial. And we quickly moving on that. At UAB we have our clinical cardio-oncology program and we are already in touch with the director for the clinical cardio-oncology program. So what we trying to do in that small trial is if one of the standard therapy for heart like beta blocker or ARBs inhibitor, is there any preference like one work better than the other in the standard care? So first we doing that project, then we obviously looking forward if one small clinical trial can be done with paquinimod. I strongly believe it should be helpful.   Cindy St. Hilaire:        That is wonderful. And so do you think... There's other chemotherapeutic agents or probably even other non-cancer drugs that cause cardiotoxicity, do you think this mechanism, this pathway, this S100A-NLRP-IL-1β axis is operative in all cardiotoxicities or do you think it's going to be very specific to the ponatinib?   Hind Lal:                     So it's certainly not all, but it'll be certainly more than ponatinib. So in our lab we are using another kinase inhibitor, which is osimertinib and it's not published yet, but now we know that it's also cardiotoxic because it's taking metabolic root or energetics disruption but not this pro-inflammatory part, but we're doing another project which is strep pneumonia induced cardiac dysfunction, which is called pneumonia. So strep pneumoniae, which leads to the pneumonia ,and lot patient die because of the failing heart we see here in the hospitals and we see these pathways operational over there and we gearing up to do clinical trial on that aspect as well, but it's not generalized like all kind of heart will have the same mechanism.   Cindy St. Hilaire:        It's wonderful to see you're already taking those next steps towards really kind of bringing this to a translational/clinical study. So what was the most challenging aspect of this study?   Tousif Sultan:              The challenging aspect, ponatinib is a kinase inhibitor and that was surprising for us how it's activating immune cells. Generally kinase inhibitors, inhibits all the cells like that. So that was challenging. So we repeated it many times did in vitro experiment to confirm that. So we just added, just treated in vitro immune cells with the ponatinib and confirmed it. So that was little challenging.   Cindy St. Hilaire:        So what's next? You mentioned you're going to try some clinical trials, early stage clinical trials. What's next mechanistically, what do you want to go after?   Hind Lal:                     So what we are doing next and we are very, very eagerly trying to do that. So what it was done, we used the cardiac comorbidity models, but as you know, anybody who will take ponatinib will have cancer, right? So we strongly believe that we miss one factor. There was no cancer on these. So that is very logical next step. What that will allow us to do, what rescue experiment we'll have done in this paper. So we saw, "Okay, this rescue the cardiac phenotype, which is taken care of now," but very same time, we not able to demonstrate that this is happening without hurting the cancer efficacy. So if we have the dual comorbid mouse, which have CML a real thing and we have cardiac thing, then that will allow us to demonstrate, "Okay, we got something that can take care of the cardiac problem without hurting the efficacy on the cancer." And it will be best if you also help little bit to more potentiate the cancer efficacy.   Cindy St. Hilaire:        Yes. Excellent. Well, congratulations on a beautiful study, really exciting findings. Dr Lal and Dr Sultan, thank you so much for taking the time to talk with me today.   Tousif Sultan:              Thank you so much.   Hind Lal:                     Well thank you, Cynthia. We really appreciate your time. Thank you for having us.   Cindy St. Hilaire:        Yeah, it was great.   Cindy St. Hilaire:        That's it for our highlights from the February 3rd and February 17th issues of Circulation Research. Thank you so much for listening. Please check out the Circulation Research Facebook page and follow us on Twitter and Instagram with the handle @CircRes and #DiscoverCircRes. Thank you to our guests, Dr Hind Lal and Dr Tousif Sultan. This podcast is produced by Ishara Ratnayake, edited by Melissa Stoner and supported by the editorial team at Circulation Research. Some of the copy text for the highlighted articles was provided by Ruth Williams. I'm your host, Dr Cynthia St. Hilaire, and this is Discover CircRes, you're on-the-go source for most exciting discoveries in basic cardiovascular research. This program is copyright of the American Heart Association 2023. And the opinions expressed by the speakers in this podcast are their own and not necessarily those of the editors or of the American Heart Association. For more information, please visit ahajournals.org.  

Hour 3: Doug Heye, 97.1 FM Talk Political Insider, former RNC spokesman joins Mark Reardon to discuss Nikki Haley's announcement that she is entering the 2024 GOP Presidential race. Then, the new Cardinals broadcaster for Bally Sports Midwest, Chip Carey joins the show to share on his new position and talk baseball. Later, Mark brings you the Audio Cut of the Day!

Ron Coleman, Partner at The Dhillon Law Group and the host of the "Coleman Nation" podcast, joins Josh to discuss the current state of the RNC, judicial reform in Israel, and national conservatism.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this podcast, we're going to talk about: Supposed prophet Julie Green's long string of failed prophecies over the past few months Michael flynn's weird love for russia and the underlying motives behind it Mike Lindell's failed campaign to become an extremely influential figure in the republican party. He tried to become RNC chair and failed miserably. Now he thinks he holds some kind of bargaining chip. If you want to leave a voicemail, the number is 1-800-701-8573. Become a channel member: https://www.youtube.com/channel/UCo6JSNp6SuUKf-yiaBQReNA/join Patreon: https://www.patreon.com/telltaleatheist Twitter: https://twitter.com/telltaleatheist Twitch: https://www.twitch.tv/telltaleatheist Telltale: https://www.youtube.com/c/TelltaleAtheist Telltale Fireside Chat: https://www.youtube.com/c/TelltaleFiresideChat Telltale Unfiltered: https://www.youtube.com/channel/UCOB86WpguzlOEs4z93iZ7kA Telltale Reads: https://www.youtube.com/channel/UCD4ggHfCpwK0oeY4aHqvWIg TikTok: https://www.tiktok.com/@telltaleatheist Discord: https://discord.gg/KeXmEq9 PayPal: http://paypal.me/telltaleatheist Teespring: https://teespring.com/stores/telltaleatheist Podcast on iTunes: https://podcasts.apple.com/us/podcast/telltale-podcast/id1399333418 Podcast on SoundCloud: https://soundcloud.com/user-450959803 Voicemail: 1-800-701-8573

"He Gets Us" has spent hundreds of millions of dollars on advertisements claiming Jesus was a refugee. On Sunday, they're spending $20 million on a Super Bowl ad. But is this Christian evangelism, or left-wing radicalism appropriating faith for its own ends? Allie Stuckey joins Charlie to talk about this disturbing story. Then, Michael Schlichter reacts to the tumult at Project Veritas, breaks down Biden's "MAGA-lite" SOTU message, and calls for a new election strategy from the RNC.Support the show: http://www.charliekirk.com/supportSee omnystudio.com/listener for privacy information.

On this episode of Ring of Fire! President Biden's State of the Union address angered Republicans in Congress, and their extreme behavior didn't go unnoticed by the American public. We'll talk about both the responses that happened during the speech, as well as the disastrous rebuttal issued by Sarah Huckabee Sanders. Cyber criminals have a new target: Republican campaigns. Multiple Republicans have been the victims of cyber crimes with thieves stealing money from their campaign accounts, so we'll examine why these targets are so enticing to criminals (and why they only seem to be targeting Republicans right now.) MyPillow CEO Mike Lindell says that the RNC is putting him in charge of a unit to go after "election crimes," but what they're really doing is opening themselves up for a massive defamation lawsuit. And a former New York prosecutor says that the Manhattan DA's office was just about to file criminal charges against Donald Trump before Alvin Bragg took over - we'll bring you the details. All that, and more, on this episode of Ring of Fire!

Don't be deceived! There is great humor – and much joy – in the Rule of Benedict. Benedictine Sister Pat Crowley explains. Read the transcript here: https://anunslife.org/podcasts/random-nun-clips/RNC-igf057-rule-of-benedict Listen to the full episode of In Good Faith podcast here: https://anunslife.org/podcasts/in-good-faith/igf057-pat-crowley Don't forget to call us and leave a message. Tell us what you like, ask a question, or just say hi. Call 913-214-6087. Let us know your thoughts about the podcast by taking this short survey! Your input helps us shape the future of Random Nun Clips! Click HERE to take the survey. Thank you!

Mike Lindell talks about his bid for the Chairman of the Republican National Committee (RNC) and how Governor Ron DeSantis held a "Truth" panel with a Dominion attorney, Libby Locke. Plus! His new MyPillow 2.0 pillow is amazing!--Get Doug's new book: “Re-Making the American Political System” at his website: www.DougBillings.usPlease subscribe to my show at www.DougBillings.usClick on the Subscribe tab! CHEAP! $10/month or $120/year. Even WOKE unemployed Commusocialists could afford this!

Dr. Jason Dean explains why people are getting more sick more often - and how to get WELL again!Mike Lindell talks about his bid for the Chairman of the Republican National Committee (RNC) and how Governor Ron DeSantis held a "Truth" panel with a Dominion attorney, Libby Locke. Plus! His new MyPillow 2.0 pillow is amazing!

With President Biden set to deliver his State Of The Union Address, what political achievements will he look back upon, and what policy will the President present to Congress moving forward? Democratic Strategist and Co-Host of The Five Jessica Tarlov, and Fox News Contributor and former Chairman of the House Oversight Committee Jason Chaffetz join to discuss the agenda that President Biden has been able to advance during his time in office, what his address to the nation will encompass, and the challenges that his administration faces heading into the 2024 election.   Last week, Ronna McDaniel was reelected to her fourth consecutive term as Chairwoman of the Republican National Committee. Many Republicans expressed concern over the party's future due to their disappointment with the 2022 Midterm Election results. Now, the RNC is looking ahead at elections in 2023 and 2024 to make gains and ignite its voter base. Former Senior Counselor to President Trump, President of KAConsulting, and FOX News Contributor Kellyanne Conway joins the Rundown to discuss Ronna McDaniel's legacy within the RNC, what her reelection means for the party's future, and what she can do to unite Republicans and pick up wins in upcoming elections. Learn more about your ad choices. Visit megaphone.fm/adchoices

Why do major donors donate to the RNC when it's so useless? Trying to de-fund the RNC. Did we back the right horse in WW2? Fixing America's 'flats' problem. The Democrats have shamed your values for decades; it's time to take their tactics and use them.See omnystudio.com/listener for privacy information.

Mike Lindell joins the show to discuss the unexpected and sudden death of Diamond, The RNC and his appearance on Jimmy Kimmel. Email all questions to DiamondandSilk@gmail.comDiamond Brought the Fire, Silk Will Stoke The Flames. Sponsors: Use Promo Code: TrumpWon 1. http://MaskDerma.com2. https://TheDrArdisShow.com/shop-all/3. http://CBSpray.com4. https://DrStellaMD.com5. https://MyPillow.com/TrumpWon Save up to 66% Visit http://SupportDiamondandSilk.com to Become a Monthly Supporter Follow Diamond and Silk on https://FrankSocial.com/u/DiamondandSilk Follow Diamond and Silk on https://TruthSocial.com/@DiamondandSilk Follow Diamond and Silk on https://Gettr.comSee omnystudio.com/listener for privacy information.

In this week's episode, North Dakota bans Heffalumps AND Woozles, long-winded priests are about to get the hook like Showtime at the Apollo, and we'll learn that Jehovah's Witnesses come pre-shunned. --- To make a per episode donation at Patreon.com, click here: http://www.patreon.com/ScathingAtheist To buy our book, click there: https://www.amazon.com/Outbreak-Crisis-Religion-Ruined-Pandemic/dp/B08L2HSVS8/ To check out our sister show, The Skepticrat, click here: https://audioboom.com/channel/the-skepticrat To check out our sister show's hot friend, God Awful Movies, click here: https://audioboom.com/channel/god-awful-movies To check out our half-sister show, Citation Needed, click here: http://citationpod.com/ To check out our sister show's sister show, D and D minus, click here: https://danddminus.libsyn.com/ To hear more from our intrepid audio engineer Morgan Clarke, click here: https://www.morganclarkemusic.com/ --- Headlines: Diatribe story: https://religionnews.com/2023/01/26/he-gets-us-organizers-hope-to-spend-1-billion-to-promote-jesus-will-anyone-care/ Idiot Bill in Montana would ban everything in science class except “scientific fact”: https://ncse.ngo/draft-antiscience-bill-montana Nebraska Democrat trolls anti-drag bill by filing an amended version to ban church camps: https://www.lgbtqnation.com/2023/01/democrat-files-bill-to-ban-church-youth-camps-as-hotbeds-of-child-abuse-religious-indoctrination/ ND bill aims to ban accommodations for students who identify as trans or 'animal species': https://www.christianpost.com/news/north-dakota-bill-seeks-to-ban-accommodations-for-trans-animal-students.html Mike Lindell will run “election crime unit” for RNC in 2024: https://www.rawstory.com/mike-lindell-election-crime-unit/ Pope says long homilies are terrible and priests need to keep it under 10 minutes: https://www.ncronline.org/vatican/vatican-news/long-homilies-are-disaster-keep-it-under-10-minutes-pope-says

Last Friday, Charlie watched in-person as more than a hundred RNC members voted to ignore their base and betray their interests. Today, he sits down with Tyler Bowyer to discuss what happened at the meeting: What was said, what the votes were, and what the RNC members really believe. Then, they turn to the most important question: What's next?Support the show: http://www.charliekirk.com/supportSee omnystudio.com/listener for privacy information.

Well, it's happened. Stigall's Chiefs of Kansas City versus his other broadcast home with the Eagles in Philadelphia. Philly sports talk host Mark Farzetta helps Stigall sort through his loyalties and the games yesterday. Former NYPD detective Rob O'Donnell discusses the police beating death in Memphis and Stigall discusses the open borders, the RNC fight, the Pelosi hammer attack, and Trump's sharp elbows with DeSantis.See omnystudio.com/listener for privacy information.

MSNBC's Ari Melber hosts "The Beat" on Friday, January 27, and reports on the newly-released footage of the attack on Paul Pelosi, the latest in Peter Navarro's criminal trial, and the RNC election. Maya Wiley, Josh Marshall, and Joyce Vance join.

While Charlie is down at RNC to fight for the Republican Party, Jack Posobiec steps in to cover the other huge stories of the day — the release of the Paul Pelosi bodycam footage, and new tape of a January 6 protester who died after being beaten by police. Jack breaks it all down with Julie Kelly, author of ‘January 6: How Democrats Used the Capitol Protest to Launch a War on Terror Against the Political Right.'Support the show: http://www.charliekirk.com/supportSee omnystudio.com/listener for privacy information.

On this episode of Top Hat - Ben, Travis, and Fernando breakdown the revealing emails showing Andrew Cuomo was only focused on his book (while his policies killed elderly New Yorkers), California's ban of doctor's misinformation, Ronna McDaniel leading the RNC, insurrectionist getting 6 years while protestors of Atlanta's proposed Cop City are charged with 35 years as well as the related killing of beloved protestor "Tortuguita", the boys react to the Pelosi attack video, Memphis preparing for the backlash to the police murder of Tyre Nichols video and so much more!

It's Casual Friday! Sam and Emma host David Dayen, executive editor at the American Prospect to round up the week in news. Then, they're joined by David Feldman of The David Feldman Show! First, Emma and Sam run through updates on the charging of five Memphis cops over the brutal murder of Tyre Nichols, the right bickering over the next RNC Chair, Adam Schiff entering the race for Feinstein's seat, and DeSantis bumping 1 million Floridians off of Medicaid, before watching Tyre Nichols' mother, RowVaugn Wells, reflect on the legacy of her son. Then, David Dayen joins as he dives right into the arrival of Jeffrey Zients as Biden's new Chief of Staff, parsing through his record as an “efficiency expert” and cost cutter, and his background in consulting as worrying features for the President's primary day-to-day filter, before reflecting on Democratic establishment media's defense of Zients as a “nice guy” whose past work you should somewhat ignore. Next, David walks Sam and Emma through Chuck Schumer cutting two massive bills that would have been a step towards breaking up Big Tech, including the American Innovation and Choice online Act – essentially preventing self-preferencing – and the Open Apps Market Act – which would take on the stipend that app monopolies (Google, Apple) take from in-app purchases – as well as exploring why Schumer has acted with such fealty to the Tech regime. Wrapping up, Dayen assesses Biden's massive 2021 executive order made up of 72 actions pushing government agencies to take on an understanding of economic competition beyond the impact on prices and consumers, discussing which agencies have actually seen the biggest shift in attitude, and the importance of these types of executive action in bolstering the programs of his anti-trust candidates like Lina Khan at the FTC and Jonathan Kanter at the DOJ, before briefly touching on Pete Buttigieg's floundering at the DOT and whether that will change. David Feldman also joins as he reflects on Sam's anti-cooperative work ethic, calls out the gated community that is the Majority Report, and check's in with Sam's child, Matt Lech. And in the Fun Half: Sam and Emma discuss the politics behind the Memphis Police's quick charging of their fellow cops for the murder of Tyre Nichols, Ron DeSantis asks why the hell the RNC is in DC, the nation's capital, and Matt Gaetz and Geraldo Rivera bring a tepid fight to Hannity over the debt ceiling debate. They also discuss Project Veritas' honey potting of a no-nothing Pfizer worker, Adam from Virginia talks to this show (of all shows) about day trading, and Garret from Michigan recommends the work of Nick Turse and discusses giving history teachers the freedom to discuss America's violent past, plus, your calls and IMs! Check out David's work at the Prospect here: https://prospect.org/topics/david-dayen/ Check out The David Feldman Show here: https://www.youtube.com/c/DavidFeldman/featured Become a member at JoinTheMajorityReport.com: https://fans.fm/majority/join Subscribe to the ESVN YouTube channel here: https://www.youtube.com/esvnshow Subscribe to the AMQuickie newsletter here: https://am-quickie.ghost.io/ Join the Majority Report Discord! http://majoritydiscord.com/ Get all your MR merch at our store: https://shop.majorityreportradio.com/ Get the free Majority Report App!: http://majority.fm/app Check out today's sponsors: Sunset Lake CBD: Sunset Lake CBD is a majority employee-owned business that pays a minimum wage of $20/hour. Visit https://sunsetlakecbd.com and use code TINCTURE at checkout to save 35% on all tinctures. Also, Use code Leftisbest and get 20% off your purchases! Aura: Go to my sponsor https://aura.com/majority to try 14 days free and let Aura go to work protecting your private information online Manukora Honey: If you head to https://manukora.com/MAJORITY you'll automatically get a free pack of honey sticks with your order-a $15 value! ZBiotics: Go to https://thld.co/zbiotics_majority_0123 and get 15% off your first order of ZBiotics Pre-Alcohol Probiotic by using my code MAJORITY at checkout. Follow the Majority Report crew on Twitter: @SamSeder @EmmaVigeland @MattBinder @MattLech @BF1nn @BradKAlsop Check out Matt's show, Left Reckoning, on Youtube, and subscribe on Patreon! https://www.patreon.com/leftreckoning Subscribe to Discourse Blog, a newsletter and website for progressive essays and related fun partly run by AM Quickie writer Jack Crosbie. https://discourseblog.com/ Check out Ava Raiza's music here! https://avaraiza.bandcamp.com/ The Majority Report with Sam Seder - https://majorityreportradio.com/

Why did Ronna McDaniel win another term as RNC Chair? Could it have something to do with leaders who define "the rules" as "whatever Ronna says"? The RNC race didn't go the way we wanted, but it wasn't for lack of effort from Charlie and friends. Charlie and John Fredericks join guest host Jack Posobiec live from the floor of the RNC meeting, sharing what they learned from face-to-face interactions with the RNC's voting members. Plus, the show listens in on the speeches of RNC officials, which may hint at what it cares about...and what it doesn't.Support the show: http://www.charliekirk.com/supportSee omnystudio.com/listener for privacy information.

Guests: Quinta Jurecic, Harry Litman, Rep. Ruben Gallego, Betsey StevensonHow Donald Trump's wild goose chase uncovered potential criminal conduct by Donald Trump. Tonight: new reporting on the weaponization of American government by way of the Durham probe—and how the MAGA House plans to go further. Then, Mike Pillow's last stand to run the RNC as a Trump rival takes his first poke. Plus, Congressman Ruben Gallego on his campaign to unseat Sinema in Arizona. And why the Biden White House is taking another victory lap on the economy—and warning about what Republicans have in store.

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Only one day is left before the climactic clash for the job of RNC chair. Charlie clues listeners into what the powers that be are trying to keep quiet, how the race currently stands, and why it matters so much. Then, Congressman Matt Gaetz joins with his own thoughts on what the GOP must do to turn things around, as well as offering a humorous summary of the FBI's own internal "Russian Collusion" scandal. Charlie also teases his exclusive interview with Ron DeSantis that is dropping VERY soon…Support the show: http://www.charliekirk.com/supportSee omnystudio.com/listener for privacy information.

The 2022 Red Wave turned out to be a Red Ripple...but not in Florida. In Florida, the Republican Party works, it fights, and it wins. Florida Governor Ron DeSantis joins Charlie for an exclusive interview, where he explains why his party has been so successful while becoming the national left's number-one enemy. Topics include his purge of CRT from the state's schools, his plan to transform a woke college into a "Hillsdale of the South," the GOP's crippling "consultant problem," and the need for change at the RNC. It's a wide-ranging interview with a Republican superstar you don't want to miss.Support the show: http://www.charliekirk.com/supportSee omnystudio.com/listener for privacy information.

Joe Biden's campaign "beat" Donald Trump. He got "the most votes in American history." So: Who was Joe Biden's campaign manager? Why aren't they more famous? Raheem Kassam joins Charlie to suggest a compelling theory as to why. Then, Kurt Schlichter joins to break down the final showdown between Harmeet Dhillon and Ronna Romney McDaniel just days ahead of the RNC's annual meeting to pick its new chair.Support the show: http://www.charliekirk.com/supportSee omnystudio.com/listener for privacy information.

Next Friday is the most important day for conservatism between the midterms and the 2024 primaries: They're the day the RNC will choose its next chair and by extension its strategy for the next two years.  Harmeet Dhillon joins to discuss her campaign and her reform agenda if she wins. Plus, Tyler Bowyer chats with Charlie about an important question: If the RNC race is so important, why is it happening quietly and behind closed doors?Support the show: http://www.charliekirk.com/supportSee omnystudio.com/listener for privacy information.

Republicans may have underperformed in the midterms, but the RNC chair fight is not about changing the party's direction. For the base, it's about out-suing the "cheating" Democrats. Plus, the free-for-all in Chicago's mayoral race, and the Oscar noms. Dave Weigel joins Charlie Sykes. Learn more about your ad choices. Visit podcastchoices.com/adchoices

On Wednesday's Mark Levin Show, the White House won't talk about Biden's classified documents, the DOJ won't talk, and the special counsel's office can't talk. The National Archives won't talk about this either, but they couldn't wait to comment on Trump's classified documents. The DOJ has put up an iron curtain around this issue. We are in the midst of a continuing cover-up. The Biden plan is delay, obstruct and counterattack. Then, USA Today wrote a phony fact check saying Biden had the power to declassify documents as Vice President. The president alone, not the VP, has the authority to classify and declassify at will solely because of his plenary power over the executive branch. Also, 16 high schools in Northern Virginia didn't notify students of their national merit recognition because of CRT and DEI. This equity crap, which is Marxism, is destroying your kids. Think of how much damage this does to students who work hard and study to be the best only not to be recognized with possible college scholarships. Have we lost all desire to be competitive and base success on merit? Parents should consider some kind of civil action against the school board and superintendent. Finally, Harmeet Dhillon calls in to discuss her race for RNC chair. Learn more about your ad choices. Visit podcastchoices.com/adchoices

The GOP has had three disappointing elections in a row, yet Ronna McDaniel still thinks she deserves a fourth term at the top of the RNC. Harmeet Dhillon joins Charlie to make her case for taking over, and describes how she would get the GOP back on a winning footing. Plus, Darren Beattie of Revolver News was the first person to demand a new Church-style Congressional Committee for bringing the intelligence apparatus to heel. Now, he joins the show to explain how changes to the U.S. deep state mean that just copying the original committee isn't enough.Support the show: http://www.charliekirk.com/supportSee omnystudio.com/listener for privacy information.