Podcasts about stem cell biology

Welcome to Episode 255 of Autism Parenting Secrets. This week's conversation spotlights a powerful intervention more parents are getting curious about—EBOO.Our guest is Dr. Phillip Yoo, an expert in regenerative medicine and a featured speaker at the Autism Health Summit.He unpacks why this therapy is gaining attention as a “blood oil change” that helps the body eliminate what it can't detox on its own. From inflammation to allergies to overall vitality, clean blood makes a difference. Dr. Yoo explains how EBOO works, who it's for, and what outcomes are possible, especially for adults and older children with the right support.We also explore simple, foundational strategies that are free and essential for healing, from grounding to sunlight to strength-building.This episode is about equipping parents with knowledge so they can explore better options and take the next right step for their child.The secret this week is…EBOO Cleans The Blood, Calms The FireYou'll Discover:Why EBOO Is Like A “Blood Oil Change” (2:16)How EBOO Helps With Chronic Inflammation & Allergies (7:05)The Importance of Testing the Microbiome Before Supplementing (10:36)How Light, Water, Air, and Grounding Support Healing (13:15)What To Do Before Trying High-End Interventions (14:09)About Our Guest:Dr. Phillip Yoo is currently doing regenerative medicine research as part of his Ph.D. program in Stem Cell Biology from the Panama College of Science. His focus includes keeping the blood vessels clean, extracorporeal blood oxygenation/ozonation (EBOO), and treating chronic inflammation and pain. He's a passionate advocate for detoxifying the body and restoring health by optimizing how the body heals itself.Learn more about his work: www.dryooeboo.comAdditional Resources:To learn more about personalized 1:1 support, go to www.elevatehowyounavigate.comTake The Quiz: What's YOUR Top Autism Parenting Blindspot?If you enjoyed this episode, share it with your friends.

Listen to ASCO's Journal of Clinical Oncology Art of Oncology poem, "The First Hero” by Christopher Kim, who is a research assistant at Institute for Stem Cell Biology and Regenerative Medicine at Stanford University. The poem is followed by an interview with Kim and host Dr. Mikkael Sekeres. Kim reflects on his post-surgery sonnet. TRANSCRIPT Narrator: The First Hero, by Christopher Kim, BS  When he is like this—eyes closed, face still— he is unfamiliar. He wears a face younger than usual; fragile limbs washed in fluorescent light, eyes blurred with a diagnosis or ripe hyacinths or the last words we shared. Be good, son. Be bright. When he is still, anesthetized into memory, so too are the aphids in the garden. Lines of buzzing bodies descended from flight but clustered in quiet surrender. Fathers of sons who are trying to heal, who are failing, who retreat into the silence of sterile rooms. A heartbeat stutters and everything sings. Like the birds we watch outside the ICU window: how they peck at unyielding concrete and fill themselves with sharpness, their bodies frenzied, their bodies temporary.   Mikkael Sekeres: Hello and welcome to JCO's Cancer Stories: The Art of Oncology, which features essays and personal reflections from authors exploring their experience in the oncology field. I'm your host, Mikkael Sekeres. I'm Professor of Medicine and Chief of the Division of Hematology at the Sylvester Comprehensive Cancer Center, University of Miami. Today, I am so thrilled to be joined by Christopher Kim. He's a research assistant at the Institute for Stem Cell Biology and Regenerative Medicine at Stanford University. In this episode, we will be discussing his Art of Oncology poem, “The First Hero.” At the time of this recording, our guest has no disclosures. Both he and I have agreed to address each other by first names during the podcast. Chris, welcome to our podcast and thank you for joining us. Christopher Kim: Of course. Thank you so much for having me. It's just such an honor to be here. Mikkael Sekeres: We absolutely loved your poem. It was incredible and addressed a topic I think a lot of us face at some point in our lives and that's when we see a family member who's sick. Before we get into that, I was wondering if you can tell us a little bit about yourself. Where are you from and how did you get to this point? Christopher Kim: Absolutely, yeah. As you mentioned before, I'm working as a research assistant at the Stanford Medical School and I pretty much only recently graduated from college so I feel like I'm still in this like ‘in between' stage. I'm a Bay Area native. I went to Stanford for undergrad, just kind of stayed on with the lab that I worked with while I was an undergrad. I would like to go on to medical school in the future. I'm learning a lot working as a research assistant, getting some hands-on experience with basic biology research. And another thing about myself is I'm an avid musician, play violin, play guitar. I like to sing. And of course, I really enjoy writing as well. Mikkael Sekeres: That's a great background. Well, we definitely need more doctors who are writers, musicians and singers. So you fit that bill. And then the fact that you do some lab based research is just amazing. You sound like a polymath. Christopher Kim: Oh, I don't know about that. I try my best. Mikkael Sekeres: Can you tell us a little bit about your own story as a writer? How long have you been writing poetry? When did you get started? And how did you get started? Christopher Kim: Yeah, absolutely. So, I've always written sort of on my own, so I don't think I ever had the courage to share my writing with others because, you know, it's kind of a vulnerable thing to share your inner thoughts with someone. So I have been kind of writing on my own since maybe late middle school and early high school. That's when I started putting my thoughts onto paper. But I only recently started to submit my poetry to, you know, these journals because, you know, after a while I was thinking, I think they're worth sharing with others because maybe some people may be going through similar situations where they can feel a little bit encouraged by the words that I write in terms of, you know, feeling the emotions that they feel. Mikkael Sekeres: Well, lucky for us, you made that decision. So when you were an undergrad, did you take any writing courses? Because it's interesting, you've been in the area of writing since you were in middle school, high school. That must have continued through college. And sometimes formal courses help us refine those skills. But then there are also plenty of examples of people who just did it on their own. Christopher Kim: Absolutely. The main writing course I took, funnily enough, they weren't really creative writing courses. They were more rhetoric based or kind of just like the regular English writing classes at college undergraduates take. However, I did have a group of friends who I would share my writing with. I think that was like the most important part of my sort of evolution as a writer. Because before I would just kind of write on my own and maybe kind of hide it away, you know, in my little locked box, I guess. But then having this opportunity to meet other people my age, my peers, who, you know, I finally gained enough kind of courage to– I say courage, but I really mean, like I finally gained enough comfort to share it with them. And, you know, gaining their feedback and seeing their response was really the most important part of, I think, my writing in college. So not necessarily like formal classes, but more like the people I met and how they responded to my writing, which is- I'm really thankful for them. Mikkael Sekeres: You know, it's so interesting because there is this temptation to be like Emily Dickinson and write your poems and squirrel them away in your desk and never show them to anyone. And then, you know, the body of your work is discovered posthumously, which I think is kind of sad. I mean, you know, great that we have Emily Dickenson poetry, but it would have been nice that, you know, she had known how appreciated she was during her lifetime. Christopher Kim: Oh, absolutely. Mikkael Sekeres: And I think the hardest first step is that word that you use, courage. The courage to identify people outside of ourselves, to share our poetry with, or our narrative pieces. So how did you find those people? Christopher Kim: It's often the case that, you know, you make your closest friends when you kind of struggle together. So I think a lot of these friends I met were through taking courses together that were difficult and that sort of combined, I don't want to say misery, that's maybe too strong a word, combined struggle against one common goal. I think that's when we started becoming close. And then it was like outside of a writing context. But I think, I don't know, it's like part luck and part finding these people in these classes and then having conversations with them late at night and then eventually going towards sharing your arts, whatever. Some of them are musicians. They share their music. Some of us share our writing. Mikkael Sekeres: Yeah. No, I hear you. There's that shared experience of being in difficult situations. I think a lot of us who've gone through undergrad and med school and then became doctors and started our training, we have incredibly close friends. We met in our residencies and fellowship because those were major stressor points in our lives and major transitional phases also when we felt that we grew. The other aspect that I've heard in identifying people to be first readers of your poetry or prose is to identify people you trust. People who are friends will give you a good read, will be appropriately critical, and will also be encouraging. You need those people to feed back to you truth about the quality of your writing and provide substantive criticism that helps you grow as a writer. Christopher Kim: Definitely agree. You know, you've found your true friends when they're not afraid to criticize you because they're so close to you and they really want you to be better. So, yeah, I definitely agree with that. Mikkael Sekeres: Yeah. And those who will take it seriously where, I think plenty of times in my own life where I've given a piece of writing to somebody, hoping for good feedback, and then you feel like you have to hound them to finally get that feedback. And obviously they're not invested in it, as opposed to a trusted body of readers where they are going to take it seriously, they're going to read it closely, and then they're going to get back to you without you feeling as if you're imposing on them. Christopher Kim: Absolutely. Yeah. It's very valuable once you've found that group of people or friends, and you know, I still contact them regularly today. So, yeah, as you mentioned, you know, I think it's definitely like maybe a lifelong process or lifelong friendship where you can always go back to them for sort of that support. And you also are able to provide that support for your friends, too. Mikkael Sekeres: Yeah. I'm curious about your writing process. What triggers you to start a poem? And, you know, how do you face that dreaded blank page? Christopher Kim: Bay Area traffic can be very long and the commute can be pretty rough. Mikkael Sekeres: Not at all like that in Miami, by the way. In Miami, we just breeze through traffic. Yeah, not at all. Christopher Kim: I would love to visit someday to compare. But yeah, Bay Area traffic can be pretty rough. As much as I love podcasts and music, there comes a point where I kind of run out of things to listen to after a while. So I really found myself driving along, but then letting my thoughts wander. And funnily enough, that's when my creative inspirations hit. Maybe it's because there's something about driving that's like the perfect amount of not thinking. You know, it's like an automatic process and that let's your– obviously I'm paying attention to the road - but you kind of let your mind wander through creative thoughts, and that's on place of creative inspiration. I've had close family members who have struggled with cancer specifically, and other serious health issues, and I've had experiences being a caretaker for them, like ‘The First Hero'. Being in that position really inspires you to write, I think, for me. Mikkael Sekeres: So I wonder if I could follow up on that and if you're only comfortable doing so. Can you tell us what prompted you to write “The First Hero”? Christopher Kim: So it's kind of a combination of experiences. My grandfather struggled with cancer for a long time, and eventually he passed away from cancer. Mikkael Sekeres: I'm sorry. Christopher Kim: I appreciate that. Thank you. And he had cancer when I was a young child, which luckily went into remission for a couple years. But then later on, you know, as I started college, that's when it came back, and that's when he passed. And I think seeing his struggles with cancer, that was one big part of inspiration for this poem. But also another thing was my father also went through some health issues where he had to go through surgery and a long period of recovery, and he still kind of struggles with some issues today. And seeing people that you love that much in a position where it's really hard, especially when they're father figures in your life. They're your grandfather and your father. And, you know, when you're a kid, you know, your dad is like, they're a superhero. Your dad is the hero who can do anything, who can achieve any answer, any question you have, who can build anything you want, can buy you things, you know, all that stuff. But now seeing them in this reverse state of being vulnerable and not being able to do too much, it really affected me. And those two experiences were my main inspiration for this poem. Mikkael Sekeres: That was really beautifully said, Chris. I'm a parent of three, and I think that it comes with a lot of responsibility to remember that just carrying the title of mom or dad implies so much to one of your own children that you have to remember the import of everything that you do for them, for your kids, and everything that you say. And it carries just that much added significance because of the role we play as parents. It's so interesting to hear it enunciated by you in that way as well. And I think part of what makes good parents, there are a thousand things that go into the formula of a good parent, and we only know for sure if we made it, if, depending on the amount of therapy our kids have to go through when they're older, right? I think part of that, though, is remembering the great responsibility that comes with just simply the title of being a parent. Christopher Kim: Absolutely. Mikkael Sekeres: You started to talk a little bit about this. I'm curious about how the dynamic between parents and children changes when a parent is sick. Christopher Kim: Yeah, it's kind of a reversal of roles in a way, because your parents, when you're born, you're the most vulnerable. They're responsible for sort of ushering you into this world, keeping you alive. Seeing your parents grow older and seeing them aging is a tough experience. And my mom often tells me whenever she would see her parents, after a while, in her mind, she still sees her parents as when they were their younger selves, when she was younger. But then suddenly it would hit her that they're, like, much older and that also makes you feel a little bit more aware of how you are aging and how much older you are. But at the end of the day, they're always going to be your parents. Mikkael Sekeres: They really are. Our parents age and we age with them, and we evolve in how we view parents, and we all go through this, and I don't think it ever ends until your parents pass. I'm sure you're familiar with this. There's a saying that you never really become an adult until your parents pass. Christopher Kim: You mentioned that you're more aware of what parenthood is as you get older. I mean, obviously I don't have any kids myself, but I'm sure my parents always USED say to me, you know, “You'll understand when you have kids.” Mikkael Sekeres: You sort of do. You sort of do. Christopher Kim: I sort of do. Right, exactly. Mikkael Sekeres: My dad always said to me that parenting is unskilled labor. So you sort of get it when you're a parent, you're still really figuring it out. Christopher Kim: Absolutely. Yeah. And the older I get, it's like I realize. I think I've gained more appreciation for the sacrifices my parents have made for me, and I've definitely taken their parenthood lessons to heart for whenever, if I choose to have kids later on. Mikkael Sekeres: So that's great. I'm sure they'd be thrilled to hear that, Chris. I wanted to end with one last question for you. Are there poets who've been a particular influence on you or favorite poets you want to name? Christopher Kim: One name that kind of comes to mind is there's a poet named Ocean Vuong. Their work blends together personal history and like, family history with beautiful lyricism. They always feel like musical in a way. Their words kind of often linger on with you long after. Mikkael Sekeres: That's great. Well, listen, Chris Kim, I'd like to thank you so much for joining us on today's podcast and for your absolutely beautiful poem, “The First Hero.” Christopher Kim: Thank you so much for having me. I'm super thrilled to be on. This is my first podcast ever, so it was such a great experience. I felt so welcomed. So thank you for, you know, hearing my thoughts or listening to my thoughts. I appreciate it. Mikkael Sekeres: Well, you're good at them. Keep them up. Until next time. Thank you for listening to JCO's Cancer Stories: The art of Oncology. Don't forget to give us a rating or review and be sure to subscribe so you never miss an episode. You can find all of the ASCO shows at asco.org/podcasts. Until next time. Thanks so much for joining us.   The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity or therapy should not be construed as an ASCO endorsement. Like, share and subscribe so you never miss an episode and leave a rating or review.  Guest Bio: Christopher Kim is a research assistant at the Institute for Stem Cell Biology and Regenerative Medicine at Stanford University.

I hope you're having a great week so far. We're currently on a little podcast break at Working Hard, Hardly Working whilst we work on something hugely exciting which is coming very soon and I focus on opening the first ever TALA store which I still cannot believe is happening! But you know I would never leave you without inspiring content on a monday morning! So I've picked my absolute favourite episodes from the nearly 130 we've released. Today's is with the geneticist & fertility researcher Dr Helen O'Neill. Dr O'Neill is a leading expert in reproductive science, she's a lecturer in reproductive and molecular genetics at University College London, she has a Masters in Prenatal Genetics and Fetal Medicine and a PhD in Stem Cell Biology. She is also the founder and CEO of Hertility Health, an award-winning bio-tech business specialising in fertility testing that has raised over £5 million since launch.Fertility is obviously a hugely sensitive topic, but it's also one that we never talk about for exactly that reason. When I started this podcast, I wanted it to cover the important topics that we never get taught, and I learnt so so much from Helen that I really couldn't believe I haven't researched or known before. If you're thinking about switching off right now because you find the idea of fertility testing terrifying like I do, I promise you it's worth sticking it out and listening to this one. However, if you are someone who is currently struggling to conceive, or finds fertility conversations particularly hard, this is an episode to skip.+HELEN'S LINKS:Hertility: https://hertilityhealth.com/Instagram: https://www.instagram.com/dr.helenoneill/?hl=en +MY LINKS: https://gracebeverley.komi.io/+SHREDDY, TALA and THE PRODUCTIVITY METHOD are my own brands, therefore any mention of them - whilst not being a sponsorship - is monetarily endorsed. As usual, sponsorships do not change my opinions nor my honesty, but I will always disclaim to make sure motives are clear

Daniel Tausan holds a graduate degree from the University of British Columbia in Stem Cell Biology with a Bachelor of Science in General Biology. He worked in research in the molecular profiling of exercise, looking into comprehensive blood panels in search of biomarkers for predictive health analytics with Molecular You and UBC's School of Kinesiology to develop methods for biological age calculation.He spent his early 20s with the Canadian National Waterpolo Team and coached the next generations of athletes to participate in the youth Pan-American games and World Championships. He personally trained clients for general fitness goals and athletic performance and continued to share the biological knowledge of the molecular world from his scientific pursuits.Asthma, allergies and gastrointestinal challenges throughout his early years kept him eager to explore regenerative principles and the healthcare systems. Although the academic and industry surrounding the molecular biological revolution were exploding few professionals were present to help the public interact and integrate with the newfound biological knowledge. With a love for education and working directly with people he stepped away from academics. He launched Timeline Sciences to put “you” on the timeline aligned with your unique genome and goals.https://timelinesciences.com/Sponsors:https://skylum.evyy.net/c/3290446/179...https://invideo.sjv.io/c/3290446/1543...https://mindbloom.sjv.io/c/3290446/15...https://daily-high-club-affiliate-pro...https://www.opus.pro/?via=a28600https://goodbru.com/?sca_ref=8203535....DONATE TO THE CHANNEL: https://www.paypal.com/donate/?hosted...Join this channel to get access to perks:   / @minddog  https://tweetscraper.io?via=minddog

Dr. Marius Wernig is a Professor of Pathology and a Co-Director of the Institute for Stem Cell Biology and Regenerative Medicine at Stanford University, where his research interests include direct reprogramming and neurological disease modeling. He talks about his early work reprogramming neuronal cells from fibroblasts, adopting iPSCs, and growing his lab. He also discusses his recent research on cell therapy for brain and skin diseases, as well as his musical talents outside of the lab.

In this episode of Hope Natural Health, Dr. Erin chats w/guest Daniel Tausan about how to transform your health through science.   Daniel Tausan holds a graduate degree in Stem Cell Biology from the University of British Columbia. He spent 4 years into his PhD exploring molecular profiling of exercise before the pandemic pushed him to work with clients and clinics starting his scientific consultancy, Timeline Sciences, helping bridge the gap between novel biotechnology, individualized data and human health.   He shares the regenerative principles of stem cell biology complete with nutrition, exercise, and mindset to bring people up to their best selves. Whether they've lost their health and need help dismantling disease or want to cut through the noise and follow fundamental principles for lifelong health and longevity. During this episode you will learn about: How stem cell biology principles help us better understand and support women's hormonal health and wellness Specific lifestyle changes recommended for women interested in longevity The basics of stem cell regeneration Website:  https://timelinesciences.com/ Social Media: https://www.instagram.com/timelinesciences/   For more on Dr. Erin: Work with Dr. Erin here: https://p.bttr.to/3E88ps4 Buy Dr. Erin's Supplements here: https://drerinellis.com/shop Get the Period Productivity Planner here:  https://www.amazon.com/dp/B0BBYBRT5Q?ref_=pe_3052080_397514860 Download the FREE Menstrual Cycle Nutrition Guide here: https://detox.drerinellis.com/ Watch The Free Video "7 Hormones Affecting Your Weight Loss Goals" here: https://weightloss.drerinellis.com/ Let's Be Friends: Follow Dr. Erin on Instagram: https://www.instagram.com/dr.erinellis/ Follow Dr. Erin on Facebook: https://www.facebook.com/drerinellisnmd Follow Dr. Erin on TikTok: https://www.tiktok.com/@dr.erinellis?lang=en Join the Fix My Period Private Facebook Group: https://www.facebook.com/groups/470429440943215 Bookmark Dr. Erin's Website: https://drerinellis.com/ Subscribe to Hope Natural Health on YouTube: https://www.youtube.com/channel/UChHYVmNEu5tKu91EATHhEiA Follow Hope Natural Health on FB: https://www.facebook.com/hopenaturalhealth Sign up for Newsletters here: https://dashboard.mailerlite.com/forms/129653/99504448452166810/share Link to Testing: https://hopenaturalhealth.wellproz.com/   #WomensHealth #HormoneHealth #PeriodHealth #HormoneBalance #MenstrualHealth #HolisticHealth #NaturalHealing #WellnessJourney #PersonalizedHealth #RegenerativeHealth #WomenInWellness #ScienceLiteracy #HormonalHealth #LongevityTips #TimelineSciences #WellnessJourney #NaturalHealth  

Continuing Adrienne's look back at some of her favourite episodes of the Power Hour, we look at the brilliant episode with Dr Helen O'Neill, founder of Hertility.From the show notes...Dr Helen is the co-founder and CEO of Hertility, and is a lecturer in reproductive and molecular genetics and a leading expert in reproductive science. She has a Masters in Prenatal Genetics and Fetal Medicine and a PhD in Stem Cell Biology from UCL. Her research focuses on pre-implantation embryo development and the use of CRISPR genome editing to assess understanding and treatment of disorders of infertility.You can follow Dr Helen @dr.helenoneill and Hertility @hertility_healthWhy Hertility was born…For too long, women have been dismissed by the healthcare system. Their bodies are 'too complicated' to understand and their health conditions remain ‘elusive'. So, we're revolutionising reproductive healthcare and putting women front and centre of everything we do.By bringing reproductive science out of the lab and into the hands of every single woman worldwide, we're setting a new standard of scientific rigour and education in female health to nurture the Mother of all movements - one powered by a new generation of women who back their bodies and their life choices. Hosted on Acast. See acast.com/privacy for more information.

PART 1 OF OUR EPISODE WITH DR. HELEN O'NEILL. This episode we focus on hormone health and answer the questions you've always wanted to ask. Dr. Helen O'Neill is a top expert in reproductive science and teaches reproductive and molecular genetics at University College London. She has a Master's in Prenatal Genetics and Fetal Medicine, along with a PhD in Stem Cell Biology. She's also the founder and CEO of Hertility Health, an award-winning biotech company specializing in fertility testing. Listen to the end for a discount on Hertility Health tests! Helen's Instagram: https://www.instagram.com/dr.helenone... Hertility: https://hertilityhealth.com/team

Daniel Tausan believes that you control your health.  If you understand some basic principles about the importance of sleep, fasting, mental attitude and nutrition you can lead a long and healthy life.Daniel Tausan holds a graduate degree from the University of British Columbia in Stem Cell Biology with a Bachelor of Science in General Biology. He worked in research in the molecular profiling of exercise, looking into comprehensive blood panels in search of biomarkers for predictive health analytics with Molecular You and UBC's School of Kinesiology to develop methods for biological age calculation so that you control your health.  You can learn more about Daniel's work here.https://timelinesciences.com/

Part 2 of 4. My guest for this week's episode is Barbara Alcaraz Silva, Executive Director of Early Stage Life Sciences and Healthcare, Startup Banking at J.P. Morgan. She is also a former scientist-entrepreneur whose graduate studies focused on Telomeres and DNA Repair. Barbara has worked with many startups, including co-founding her own company, BioChron. While at the Manos Accelerator, she worked as an advisor for Biotech and Medtech companies, providing mentorship in business, fundraising, and capital, and offering guidance to startup companies. Additionally, Barbara worked as a Senior Investment Fellow at Life Science Angels, investing in up-and-coming biotechs and managing investor relationships.

How to Transform Healthcare and Take control of your wellness Journey Based on your Unique Genome with Daniel Tausan! Join us in this enlightening episode as we meet Daniel Tausan, a visionary in the world of personalized healthcare. After facing his own health challenges with asthma, allergies, and gastrointestinal issues, Daniel dedicated his life to exploring regenerative principles and the complexities of healthcare systems. With a graduate degree in Stem Cell Biology from the University of British Columbia and a Bachelor of Science in General Biology, he has a deep understanding of molecular biology and its impact on health. In this video, Daniel shares his journey from academia to founding Timeline Sciences, a company focused on integrating individual genomic data with personal health goals. Discover how Daniel's innovative approach aims to revolutionize healthcare by making genetic insights accessible and actionable for everyone. Learn about his extensive background, including research on biomarkers for predictive health analytics, coaching athletes, and his passion for education. This episode is a must-watch for anyone interested in the future of personalized medicine, the role of genetics in health, and how you can take control of your wellness journey based on your unique genome. https://timelinesciences.com/ Don't forget to like, share, and subscribe for more inspiring content that empowers you to make informed health decisions! #PersonalizedHealthcare #Genomics #DanielTausan #TimelineSciences #HealthInnovation #Asthma #RegenerativeMedicine #MolecularBiology #WellnessJourney

How to Transform Healthcare and Take control of your wellness Journey Based on your Unique Genome with Daniel Tausan! Join us in this enlightening episode as we meet Daniel Tausan, a visionary in the world of personalized healthcare. After facing his own health challenges with asthma, allergies, and gastrointestinal issues, Daniel dedicated his life to exploring regenerative principles and the complexities of healthcare systems. With a graduate degree in Stem Cell Biology from the University of British Columbia and a Bachelor of Science in General Biology, he has a deep understanding of molecular biology and its impact on health. In this video, Daniel shares his journey from academia to founding Timeline Sciences, a company focused on integrating individual genomic data with personal health goals. Discover how Daniel's innovative approach aims to revolutionize healthcare by making genetic insights accessible and actionable for everyone. Learn about his extensive background, including research on biomarkers for predictive health analytics, coaching athletes, and his passion for education. This episode is a must-watch for anyone interested in the future of personalized medicine, the role of genetics in health, and how you can take control of your wellness journey based on your unique genome. https://timelinesciences.com/ Don't forget to like, share, and subscribe for more inspiring content that empowers you to make informed health decisions! #PersonalizedHealthcare #Genomics #DanielTausan #TimelineSciences #HealthInnovation #Asthma #RegenerativeMedicine #MolecularBiology #WellnessJourney

Introduction: Host Eric welcomes Daniel, a leader in regenerative health and personalized medicine. Daniel's journey began with personal health challenges, leading to his exploration of molecular biology and stem cell research. He founded Timeline Sciences to align individuals with their unique genetic makeup and health goals. Daniel's Journey: Daniel shares his childhood struggles with severe asthma and gastrointestinal problems. His curiosity and questioning nature led him away from becoming a doctor and towards a career in science. He discusses the fascination with cellular biology and the complexity of human life at the cellular level. Stem Cell Biology and Regeneration: Daniel explains the role of stem cells in various organs and their regenerative capabilities. He highlights the differences in regenerative potential across organs, such as the intestines and the brain. The conversation delves into the importance of the stroma, the connective tissue that plays a crucial role in healing and regeneration. Science Literacy: The importance of science literacy in today's society is discussed, with Daniel emphasizing the ability to discern science from marketing and stories. He provides examples of how historical scientific data, even if initially misinterpreted, can still be valuable for contemporary research and understanding. Personalized Medicine and Regenerative Health: Daniel addresses common misconceptions about personalized medicine, stressing the importance of preventative approaches to health. He explains how Timeline Sciences helps individuals anticipate potential health issues and take proactive measures. The episode concludes with insights into how simple lifestyle changes can have significant impacts on long-term health and disease prevention. Key Takeaways: The body's innate healing capabilities are immense when supported by proper care and understanding. Science literacy empowers individuals to make informed health decisions and differentiate between factual information and marketing tactics. Personalized medicine and regenerative health are not just about treating problems but preventing them through a deeper understanding of one's body and health trajectory.

Dr Helen O'Neill is a leading expert in reproductive science, she's a lecturer in reproductive and molecular genetics at University College London, she has a Masters in Prenatal Genetics and Fetal Medicine and a PhD in Stem Cell Biology. She is also the founder and CEO of Hertility Health, an award-winning bio-tech business specialising in fertility testing that has raised over £5 million since launch. Fertility is obviously a hugely sensitive topic, but it's also one that we never talk about for exactly that reason. When I started this podcast, I wanted it to cover the important topics that we never get taught, and I learnt so so much from Helen that I really couldn't believe I haven't researched or known before. If you're thinking about switching off right now because you find the idea of fertility testing terrifying like I do, I promise you it's worth sticking it out and listening to this one. However, if you are someone who is currently struggling to conceive, or finds fertility conversations particularly hard, this is an episode to skip. Helen's Instagram: https://www.instagram.com/dr.helenoneill/?hl=enHertility: https://hertilityhealth.com/team+Download Revolut for free and get £20 when you use your card! www.revolut.com/graceCashback subject to availability. Max £200 cashback per month. T&Cs apply. £20 Reward only available until 30th April 2024 and other T&Cs apply.+TALA:Website: https://www.wearetala.com/?utm_source...Instagram: https://www.instagram.com/wearetala/?...Need help? hello@wearetala.comSHREDDY:Website: https://shreddy.comNeed help? Support.shreddy.comTHE PRODUCTIVITY METHOD:Website: https://productivitymethod.com/Need help? https://theproductivitymethod.zendesk...+THE PRODUCTIVITY METHOD, SHREDDY and TALA are my own brands, therefore any mention of them - whilst not being a sponsorship - is monetarily endorsed. As usual, sponsorships do not change my opinions nor my honesty, but I will always disclaim to make sure motives are clear. Hosted on Acast. See acast.com/privacy for more information.

Dr Helen is the co-founder and CEO of Hertility, and is a lecturer in reproductive and molecular genetics and a leading expert in reproductive science. She has a Masters in Prenatal Genetics and Fetal Medicine and a PhD in Stem Cell Biology from UCL. Her research focuses on pre-implantation embryo development and the use of CRISPR genome editing to assess understanding and treatment of disorders of infertility.You can follow Dr Helen @dr.helenoneill and Hertility @hertility_healthWhy Hertility was born…For too long, women have been dismissed by the healthcare system. Their bodies are 'too complicated' to understand and their health conditions remain ‘elusive'. So, we're revolutionising reproductive healthcare and putting women front and centre of everything we do.By bringing reproductive science out of the lab and into the hands of every single woman worldwide, we're setting a new standard of scientific rigour and education in female health to nurture the Mother of all movements - one powered by a new generation of women who back their bodies and their life choices. Hosted on Acast. See acast.com/privacy for more information.

To kick off 2024, we're bringing you an episode that's been one of our most popular. The timing is just right as many of us are headed into the new year thinking about how to live better. In this episode, Professor Helen Blau, a stem cell biologist, tells us all about how she's recruiting stem cells to regenerate youthful muscle in older people. We're thrilled to bring this episode out of the archives for another listen and renewed hope about possibilities ahead in the world of health.  Happy New Year from Russ and the team here at The Future of Everything. Contact Links:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads or Twitter/XConnect with School of Engineering >>> Twitter/XChapters:(00:00:00) Introduction & Importance of Muscles in AgingHost Russ Altman introduces the episode, the ways that muscles weakening with age affects us, and how guest, Professor Helen Blau's work with stem cells  is addressing this.(00:02:03) Regenerative Medicine & Stem CellsThe goals of regenerative medicine in enhancing the quality of life as people age. Overview of different types of stem cells and their potential.(00:04:28) Focus on Muscle: Sarcopenia and AgingEmphasizing the desire to age well, and the centrality of muscles in daily activities and how they atrophy with age.(00:07:44) Approaches to Combating Muscle AgingLack of available drugs addressing muscle wasting and potential research directions. Targeting stem cells and mature muscle fibers for rejuvenation.(00:09:09) Lab Discoveries and ChallengesDr.  Blau's lab experiments to identify and maintain functional stem cells, the breakthrough in bioengineering microenvironments & it's impact.(00:12:41) Stem Cell RejuvenationInsights into rejuvenating stem cell functions through cell therapy that lead to. (00:14:37) Inflammatory Pathways and Stem Cell ResponseDr Blau explains the importance of the wave of inflammation for stem cells, and the discoveries this lead to. (00:17:55) Broad-Scale Muscle RejuvenationExploring systemic alterations targeting inflammation pathways for global muscle regeneration. Identification of PGE-2 degrading enzyme and results of limiting this enzyme.(00:21:33) Human Trials, Challenges & Drug DevelopmentDiscussion on the prospects of translating findings to human treatments and developing an oral drug(00:24:42) Timeline and Clinical TrialsAnticipated timelines for the drug's availability for human trials and potential applications. Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads or Twitter/XConnect with School of Engineering >>> Twitter/X

Here Dr Seranova talks about the supplements she takes, and a couple that she does not. Also sleeping and a hack for getting better deep sleep. The new brain supplement that Dr Seranova talks about is now available. Dr. Seranova is a serial entrepreneur, holds an MSc in Translational Neuroscience from the University of Sheffield and a PhD in Stem Cell Biology and Autophagy from the University of Birmingham, UK.

Here Dr Seranova talks about her diet and exercise and how she thinks about these. Some links are affiliate links so we will earn a commission when they are used to purchase products. Dr. Seranova is a serial entrepreneur, holds an MSc in Translational Neuroscience from the University of Sheffield and a PhD in Stem Cell Biology and Autophagy from the University of Birmingham, UK.

Dr. Seranova is a serial entrepreneur, holds an MSc in Translational Neuroscience from the University of Sheffield and a PhD in Stem Cell Biology and Autophagy from the University of Birmingham, UK.

Here Dr Seranova answers some questions on the paper from the first interview (https://youtu.be/fsuhtgKUZRg). Particular topics we discuss, mitochondria fragmentation, de novo pathway in neurons, difference between NR & NMN. Dr. Seranova is a serial entrepreneur, holds an MSc in Translational Neuroscience from the University of Sheffield and a PhD in Stem Cell Biology and Autophagy from the University of Birmingham, UK.

Here Dr Seranova talks through her latest paper on the impact of NAD precursors (NR & NMN) on autophagy in human neuron Dr. Seranova is a serial entrepreneur, holds an MSc in Translational Neuroscience from the University of Sheffield and a PhD in Stem Cell Biology and Autophagy from the University of Birmingham, UK.

In this episode, we sit down with Dr. Khoshal Latifzai, the Co-Founder of Rocky Mountain Regenerative Medicine and an expert in regenerative and advanced non-surgical orthopedics. Specializing in advanced medical solutions, Rocky Mountain Regenerative Medicine offers a wide range of services – including stem cell therapy, hormone replacement therapy, peptide therapy, and more… Dr. Latifzai was born in Afghanistan, and in the 1990s, he emigrated to the United States at the age of 10. He is a Dartmouth Medical School and Yale University Emergency Medicine Residency program graduate and is Board Certified in Emergency Medicine. Currently, he is on a mission to optimize health with revolutionary diagnostics and custom-tailored therapeutics. Join us now to learn about: What drove Dr. Latifzai out of conventional medicine.  What peptide therapy is, how it is administered, and how it impacts the body's health.  The importance of enabling our own biology to heal itself.  How long stem cell therapy optimization lasts.  The top problems that Rocky Mountain Regenerative Medicine helps clients overcome.  You can find out more about Dr. Latifzai and his work with Rocky Mountain Regenerative Medicine by clicking here now! Take advantage of a 5% discount on Ekster accessories by using the code FINDINGGENIUS. Enhance your style and functionality with premium accessories. Visit bit.ly/3uiVX9R to explore latest collection. Episode also available on Apple Podcasts: http://apple.co/30PvU9C

Dr. Helen Blau is the Donald E. and Delia B. Baxter Foundation Professor and Director of the Baxter Laboratory for Stem Cell Biology at Stanford University. Dr. Blau's research focuses on the basic molecular mechanisms of stem cells and muscle and their application to aging, regenerative medicine, and disease. Her lab aims to understand and apply biology to improve quality of life, and their current primary focus is on understanding the gerozyme 15-PGDH. She talks about the roles of NSAIDs and CD47 in muscle regeneration. She also discusses growing cultured meat and writing a children's book!

#621: Today, we're sitting down with Carolina Reis Oliveira, co-founder of OneSkin. Carolina holds her Ph.D. in Stem Cell Biology and Tissue Engineering & in 2016, Carolina relocated to Silicon Valley from Latin America to co-found OneSkin and lead the development of the company's disruptive skin age reversal technologies. Today, Carolina joins us to discuss skincare from a scientific perspective. We dive into all things aging and anti-aging, identify which "hot" products can actually damage your skin in the long run, and she reveals the top 5 free things you can do for your skin in terms of anti-aging. We also explore which products are best for achieving better skin, why the skin around your eyes ages differently than the rest of your body, and why the health of your skin serves as a direct indicator of your overall health.   To connect with OneSkin click HERE To connect with Lauryn Evarts Bosstick click HERE To connect with Michael Bosstick click HERE Read More on The Skinny Confidential HERE To subscribe to our YouTube Page click HERE For Detailed Show Notes visit TSCPODCAST.COM To Call the Him & Her Hotline call: 1-833-SKINNYS (754-6697) This episode is brought to you by The Skinny Confidential & OneSkin Visit www.oneskin.co and use code SKINNY15 for 15% off your first purchase. This episode is brought to you by Fable Pets Fable Pets designs gear that solves problems for you and your pet, so the two of you can enjoy exploring the world together. Go to fablepets.com/skinny for 20% off sitewide and up to 35% off sets. This episode is brought to you by JSHealth JSHealth Vitamins is a science-focused vitamin and wellness brand that provides targeted formulas to help you meet your personal health goals, created using the highest quality ingredients backed by research. Go to jshealthvitamins.com/skinny and use code SKINNY for 20% your order or first subscription. This episode is brought to you by Hiya Health Hiya Health fills in the most common gaps in modern children's diet to provide full-body nourishment our kids need with a yummy taste they love. Go to hiyahealth.com/skinny to receive 50% off your first order. This episode is brought to you by AG1 If you want to take ownership of your health, it starts with AG1. Go to drinkAG1.com/SKINNY to get a free 1-year supply of Vitamin D3K2 AND 5 free AG1 Travel Packs with your first purchase. This episode is brought to you by MOON MOON Oral Beauty is reimagining oral care by elevating the everyday oral care routine into an oral care beauty experience. Get 20% off your first device purchase by using code SKINNY at moonoralbeauty.com . This episode is brought to you by Momentous Visit livemomentous.com/skinny and use code SKINNY at checkout for 15% off your first purchase. Produced by Dear Media  

Ana Faro is an Equality, Diversity & Inclusion (EDI), Culture and Workplace Wellbeing specialist, with over 15 years of experience in the Higher Education sector and with the commitment to create positive social impact. She joins Jo on this podcast to talk about mental health and her work as a specialist in Diversity, Equality, & Inclusion (DEI). Ana studied Molecular Biology & Genetics at University of Lisbon, Portugal, and has a PhD in Stem Cell Biology & Cancer from Utrecht University, The Netherlands. In 2010, Ana moved to the UK to pursue her postdoctoral studies in Developmental Neurobiology, at University College London. Throughout her career as a scientist, Ana was always committed to creating opportunities for students from underrepresented and disadvantaged backgrounds to access experience and gain insight into a career in academia. A few years ago, Ana left the bench and followed her passion for EDI to carve a new career path where she supports Academic institutions in building inclusive workplace cultures with a focus on equity of experiences, belongingness, mental health and wellbeing. Find more podcast episodes here: ⁠⁠⁠⁠⁠⁠https://access2perspectives.pubpub.org/podcast⁠⁠⁠ Host:⁠⁠⁠⁠⁠⁠ Dr Jo Havemann⁠⁠⁠⁠⁠⁠, ORCID iD ⁠⁠⁠⁠⁠⁠0000-0002-6157-1494 ⁠⁠⁠⁠⁠⁠Editing: ⁠⁠⁠⁠⁠⁠Ebuka Ezeike⁠⁠⁠⁠⁠⁠ Music:⁠⁠⁠⁠⁠⁠ Alex Lustig⁠⁠⁠⁠⁠⁠, produced by⁠⁠⁠⁠⁠⁠ Kitty Kat ⁠⁠⁠⁠⁠⁠License:⁠⁠⁠⁠⁠⁠ Attribution 4.0 International (CC BY 4.0)   ⁠⁠⁠⁠⁠⁠ At Access 2 Perspectives, we guide you in your complete research workflow toward state-of-the-art research practices and in full compliance with funding and publishing requirements. Leverage your research projects to higher efficiency and increased collaboration opportunities while fostering your explorative spirit and joy. Website: ⁠⁠⁠⁠⁠⁠https://access2perspectives.pubpub.org⁠⁠⁠⁠ --- Send in a voice message: https://podcasters.spotify.com/pod/show/access2perspectives/message

Today's episode is a conversation I had with Dan Cortes  who is an Associate research scientist in the Pera Lab at The Jackson Laboratory. Dan is originally from Mexico City, and he holds both an MD and a PhD; his research is focused on genetics, and he has a particular interest in exploring strokes.Dan was a 5 Minute Genius™ speaker for the 2023 Maine Science Festival; you can watch his talk on our YouTube Channel: https://youtu.be/77fDkYJTjHYOur conversation was recorded in June 2023.~~~~~~The Maine Science Podcast is a production of the Maine Science Festival and Maine Discovery Museum. It was recorded at Discovery Studios, at the Maine Discovery Museum, in Bangor, ME. The Maine Science Podcast is hosted and executive produced by Kate Dickerson; edited and produced by Scott Loiselle.The Discover Maine theme was composed and performed by Nick Parker.If you want to support the Maine Science Podcast and/or the Maine Science Festival, you can do so at our website mainesciencefestival.org at our donation page. Find us online:Website - Maine Science FestivalMaine Science Festival on social media: Facebook    Twitter     InstagramMaine Science Podcast on social media: Facebook    Twitter     Instagram© 2023 Maine Science FestivalA program of the Maine Discovery Museum 

"The Hidden Artists podcast is about people who haven't been discovered yet—entrepreneurs, musicians, someone who is creative in what they do. People have all these talents, but they don't all have an opportunity to be known for what they do. I just want to give these people a chance to be able to do what they love for a living." – Natalie DayanIn this episode, Raghu and Natalie dive into:What it's like for Natalie being born Jewish, being raised in India, and now living in Los AngelesExploring the various parts of your identityThe inspiration behind starting her podcast, The Hidden Artists, which helps artists and entrepreneurs get discoveredObtaining her Masters degree in Stem Cell Biology and Regenerative MedicineWorking with feeling lost in life, and using fear as a way to motivate yourselfThe similarities and crossovers between Hinduism and JudiasmHow we are not our thoughts, we are not our storyRaghu's adventures through India, and learning Sab Ek (All One) wisdom from Maharaj-jiHaving faith that the universe is always working for you, as well as helping you be of serviceZaChoeje Rinpoche's wisdom to "stop struggling with struggle"How with people like Natalie, the future is going to be okay"You're not your story, you're not your thoughts; who you are, of course, is way behind all of that." – Raghu MarkusSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Over the last 10 years of Stem Cell Reports, the journal has published nearly 2,000 papers across the breadth of stem cell research. In this special episode of the podcast, we are celebrating the anniversary of the journal by talking with the authors from some of the most highly cited publications in the journal's history.The guests on this episode of the podcast have collective expertise that makes them the “dream team” of muscle stem cell biology and its application to treat disease.   Akitsu Hotta is a Principal Investigator and Associate Professor in the Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University and was the recipient of the 2020 Japanese Society for Regenerative Medicine Award. His laboratory published the 2015 paper, Precise correction of the dystrophin gene in Duchenne muscular dystrophy patient induced pluripotent stem cells by TALEN and CRISPR-Cas9. Thomas Rando is the Director of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Biology at the University of California Los Angeles, where he is also Professor of Neurology and of Molecular, Cell and Developmental Biology. Dr Rando is a board-certified neurologist and a member of the National Academy of Medicine and a member of the American Academy of Arts and Sciences. He is also the 2023 recipient of the ISSCR Achievement Award, which recognizes the transformative body of work of an investigator that has had a major impact on the field of stem cell research or regenerative medicine. His laboratory published the 2015 paper, entitled, the Ex vivo expansion and in vivo self-renewal of human muscle stem cells. April Pyle is an Associate Professor in the Department of Microbiology, Immunology and Molecular Genetics at the University of California Los Angeles and a member of the Eli and Edythe Broad Stem Cell Center, the Center for Duchenne Muscular Dystrophy, and the Jonsson Comprehensive Cancer Center at UCLA. She is also an Associate Editor of Stem Cell Reports. HostMartin Pera, PhD, Editor-in-Chief, Stem Cell Reports and The Jackson LaboratoryTwitter: @martinperaJAXAbout ISSCRWith more than 4,600 members from 75+ countries, the International Society for Stem Cell Research (@ISSCR) is the preeminent global, cross-disciplinary, science-based organization dedicated to stem cell research and its translation to the clinic. The ISSCR mission is to promote excellence in stem cell science and applications to human health.ISSCR StaffKeith Alm, Chief Executive OfficerYvonne Fisher, Managing Editor, Stem Cell ReportsKym Kilbourne, Director of Media and Strategic CommunicationsJack Mosher, Scientific AdvisorVoice WorkBen Snitkoff

How do our bodies build our bodies? What does a stem cell look like? How do they know what to do? What diseases could stem cells cure? And why is Canada such a hot place for research? Dr. Samantha Yammine – known by many as Science Sam – is a stem cell biologist and science communicator and takes us back to the discovery of stem cells, chats ethical questions, spotting scams, cloning, gene-edited babies, helping your body heal faster and what advancements are being made, albeit by slowly growing in a dish. Visit Dr. Samantha Yammine's website, Links and follow her on Instagram, Twitter and TikTokDonations went to A Closer Look at Stem Cells and The Marsha P. Johnson InstituteMore episode sources and linksOther episodes you may enjoy: Genicular Traumatology (BAD KNEES), Dolorology (PAIN), Molecular Neurobiology (BRAIN CHEMICALS), Ophthalmology (EYES), Neuropathology (CONCUSSIONS), Bovine Neuropathology (HEADBUTTING), Oreamnology (MOUNTAIN GOATS ARE NOT GOATS), Malacology (SLUGS & SNAILS), Glycobiology (CARBS)  Biogerontology (AGING), Microbiology (GUT BIOME), Systems Biology (MEDICAL MATHEMATICS)Sponsors of OlogiesTranscripts and bleeped episodesSmologies (short, classroom-safe) episodesBecome a patron of Ologies for as little as a buck a monthOlogiesMerch.com has hats, shirts, masks, totes!Follow @Ologies on Twitter and InstagramFollow @AlieWard on Twitter and InstagramEditing by Mercedes Maitland of Maitland Audio Productions and Jarrett Sleeper of MindJam Media and Mark David ChristensonTranscripts by Emily White of The WordaryWebsite by Kelly R. DwyerTheme song by Nick Thorburn

The University Kidney Research Organization ( UKRO - https://ukrocharity.org/ ) is a Los Angeles-based nonprofit charity, co-founded prominent entertainment attorney Kenneth Kleinberg, inspired by his personal journey with kidney disease, focused on supporting medical research and education related to the causes, treatment, and eradication of all forms of kidney disease. Dr. Andrew McMahon, Ph.D. ( https://keck.usc.edu/faculty-search/andrew-p-mcmahon/ ) is Director of the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Provost Professor and the inaugural holder of the W. M. Keck Professorship of Stem Cell Biology and Regenerative Medicine, and is responsible for overseeing UKRO's Synthetic Kidney Project. In addition, Dr. McMahon chairs the recently created Department of Stem Cell Biology and Regenerative Medicine at the Keck School. He also holds an appointment in the Department of Biological Sciences in the USC Dornsife College of Letters, Arts, and Sciences. Previously Dr. McMahon served as professor in the Department of Stem Cell and Regenerative Biology, Department of Molecular and Cellular Biology and principal faculty member in the Harvard Stem Cell Institute, as well as led the Department of Cell and Developmental Biology at the Roche Institute for Molecular Biology. Dr. McMahon received his bachelor's degree from St. Peter's College, Oxford University and his Ph.D. from University College in London. He subsequently worked for three years as a postdoctoral fellow at the California Institute of Technology. Lewis Kleinberg, a board member of UKRO and son of Kenneth Kleinberg, is a writer/producer who has written, developed and produced projects for Sony Pictures, Walt Disney Pictures, New Regency, 21st Century Fox, TNT, Anonymous Content, BBC Productions, Renegade 83, Kapital Entertainment, and USA Network, among others, and currently creates and produces films for UKRO's website, media outreach, and benefit dinners. A graduate of the USC School of Cinematic Arts, he serves as an advisor to Donate Life Hollywood and as a mentor for USC's Compass program, which supports undergraduate students pursuing careers in regenerative medicine. Support the show

Vadim Gladyshev is a Professor of Medicine at Harvard Medical School, Director of the Center for Redox Medicine at Brigham and Women's Hospital, and Associate Member of the Broad Institute. Mahdi Moqri is an NIH Postdoctoral Fellow in Aging Research at the Sebastiano Lab at the Institute for Stem Cell Biology and Regenerative Medicine at Stanford, and a visiting scholar at the Gladyshev Lab at Harvard Medical School. Mahdi Moqri is an NIH Postdoctoral Fellow in Aging Research at the Sebastiano Lab at the Institute for Stem Cell Biology and Regenerative Medicine at Stanford, and a visiting scholar at the Gladyshev Lab at Harvard Medical School.  With the rapid expansion of aging biology research, identification and evaluation of longevity interventions in humans have become key goals of this field. Biomarkers of aging are critically important tools in achieving these objectives over realistic timeframes. Here, we advance a framework for characterizing and assessing biomarkers of aging, including consensus terminology for several key concepts in this space. We propose classification of existing biomarkers and evaluate their feasibility, age-sensitivity, mechanistic underpinnings, and response criteria.  Session summary: V. Gladyshev, M. Moqri, V.Sebastiano | Quantifying Aging - Foresight InstituteThe Foresight Institute is a research organization and non-profit that supports the beneficial development of high-impact technologies. Since our founding in 1987 on a vision of guiding powerful technologies, we have continued to evolve into a many-armed organization that focuses on several fields of science and technology that are too ambitious for legacy institutions to support.Allison Duettmann is the president and CEO of Foresight Institute. She directs the Intelligent Cooperation, Molecular Machines, Biotech & Health Extension, Neurotech, and Space Programs, Fellowships, Prizes, and Tech Trees, and shares this work with the public. She founded Existentialhope.com, co-edited Superintelligence: Coordination & Strategy, co-authored Gaming the Future, and co-initiated The Longevity Prize. Apply to Foresight's virtual salons and in person workshops here!We are entirely funded by your donations. If you enjoy what we do please consider donating through our donation page.Visit our website for more content, or join us here:TwitterFacebookLinkedInEvery word ever spoken on this podcast is now AI-searchable using Fathom.fm, a search engine for podcasts.  Hosted on Acast. See acast.com/privacy for more information.

Dr. Lorenz Studer is the Director of the Center for Stem Cell Biology at Memorial Sloan Kettering Cancer Institute. His lab exploits recent advances in stem cell biology to develop new therapies for degenerative diseases and cancer. Their projects involve directing the fate and age of hPSCs, modeling diseases, and developing cell therapies. He talks about his journey into the stem cell field and co-founding BlueRock Therapeutics. He also discusses the challenges of developing cell therapies at scale, strategies to target cognition loss in Parkinson's disease, and combining basic and translational research.

At the recent American Society of Hematology (ASH) Annual Meeting in New Orleans, Dr. Irving Weissman, Director of the Institute of Stem Cell Biology and Regenerative Medicine at Stanford University, received the 2022 Wallace H. Coulter Award for Lifetime Achievement in Hematology. In this interview, Dr. Weissman tells the story of how he entered the field, describes the monumental contributions he has made in hematology and oncology, and shares advice for medical students who are interested in becoming involved in basic science research.

In this podcast molecular Biologist Dr Elena Seranova joins us to talk through some of the exciting anti-aging and longevity compounds on the market currently, the research behind them and what they do in the body. We consider  what you should think about when deciding to take a supplement what each compound does, it's mechanism of action what aging hallmarks each compounds combats. what senescent cells are and what senolytics do, the importance of methylation  we cover Quercetin, Trimethylglycine, Nicotinamide Mononucleotide and Berberine Tune in to get the latest information on this exciting compounds and where the research is headed next.     About Dr. Elena Dr. Elena Seranova is a scientist, serial entrepreneur, and business mentor. She has now founded multiple innovative biotechnological businesses. She first studied at the University of Ioannina with a major in Psychology. Dr. Elena then started a private practice before developing an interest in neuroscience. Dr. Elena continued her studies and earned her Master's Degree in Translational Neuroscience at the University of Sheffield. She now also holds a Doctorate Degree in Stem Cell Biology and Autophagy from the University of Birmingham. Dr. Elena's expertise in these fields led her to co-found the biotech start-up SkyLab Bio. She has written several peer-reviewed articles on autophagy. Her latest business is NMN Bio. Her own experiences with supplements have inspired her to expand the market to include cutting-edge anti-ageing supplements. NMN Bio reaches New Zealand, the UK, and Europe. Dr. Elena found her passion for drug discovery and autophagy. She has endeavoured to share this with the public through her research and work as an entrepreneur.  To learn more about Dr. Elena and her work, visit NMN Bio.   Health Optimisation Consulting with Lisa  Are you struggling with a health issue and need someone who looks outside the square and someone  connected to some of the greatest science and health minds in the world? Then reach out to us at lisa@lisatamati.com, we can jump on a call to see if we are a good fit for you or visit  Lisa's Health Consulting If you have a big challenge ahead, are dealing with adversity or want to take your performance to the next level and want to learn how to increase your mental toughness, emotional resilience, foundational health, and more, contact us at lisa@lisatamati.com.   Order Lisa's Books My latest book Relentless chronicles the inspiring journey about how my mother and I defied the odds after an aneurysm left my mum Isobel with massive brain damage at age 74. The medical professionals told me there was absolutely no hope of any quality of life again. Still, I used every mindset tool, years of research and incredible tenacity to prove them wrong and bring my mother back to full health within three years. Get your copy here: https://shop.lisatamati.com/collections/books/products/relentless.   Lisa's Anti-Ageing and Longevity Supplements  Lisa's full range of anti-aging, longevity and health optimisation supplements curated by Lisa herself working with some of the best supplement producers in the world.  https://shop.lisatamati.com/ NMN: Nicotinamide Mononucleotide, an NAD+ precursor   Feel Healthier and Younger* Researchers have found that Nicotinamide Adenine Dinucleotide or NAD+, a master regulator of metabolism and a molecule essential for the functionality of all human cells, decreases dramatically over time.   What is NMN? NMN Bio offers a cutting edge Vitamin B3 derivative named NMN (beta Nicotinamide Mononucleotide) that can boost the levels of NAD+ in muscle tissue and liver. Take charge of your energy levels, focus, metabolism and overall health so you can live a happy, fulfilling life. Founded by scientists, NMN Bio offers supplements of the highest purity and rigorously tested by an independent, third-party lab. Start your cellular rejuvenation journey today.   Support Your Healthy Ageing We offer powerful third-party tested NAD+ boosting supplements so you can start your healthy ageing journey today. Shop now: https://nmnbio.nz/collections/all NMN (beta Nicotinamide Mononucleotide) 250mg | 30 capsules NMN (beta Nicotinamide Mononucleotide) 500mg | 30 capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 250mg | 30 Capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 500mg | 30 Capsules   Quality You Can Trust — NMN Our premium range of anti-ageing nutraceuticals (supplements that combine Mother Nature with cutting edge science) combats the effects of aging while designed to boost NAD+ levels. Manufactured in an ISO9001 certified facility   Boost Your NAD+ Levels — Healthy Ageing: Redefined Cellular Health Energy & Focus Bone Density Skin Elasticity DNA Repair Cardiovascular Health Brain Health  Metabolic Health   Perfect Amino Supplement by Dr David Minkoff Introducing PerfectAmino PerfectAmino is an amino acid supplement that is 99% utilized by the body to make protein. PerfectAmino is 3-6x the protein of other sources with almost no calories. 100% vegan and non-GMO. The coated PerfectAmino tablets are a slightly different shape and have a natural, non-GMO, certified organic vegan coating on them so they will glide down your throat easily. Fully absorbed within 20-30 minutes! No other form of protein comes close to PerfectAminos   Ketone-IQ Get your fuel from ketones. Ketones are nature's superfuel, proven to support energy, focus, endurance, and more. Developed alongside the U.S. military and top universities, Ketone-IQ™ delivers all those benefits in one drink. No caffeine, no sugar—just clean, on-demand energy for superior physical and cognitive performance. You can read about it here and  https://shop.lisatamati.com/products/ketone-iq%E2%84%A2?_pos=2&_sid=727714231&_ss=r   My  ‘Fierce' Sports Jewellery Collection For my gorgeous and inspiring sports jewellery collection, 'Fierce', go to https://shop.lisatamati.com/collections/lisa-tamati-bespoke-jewellery-collection.   Resources Gain exclusive access and bonuses to Pushing the Limits Podcast by becoming a patron! You can also connect with Matty on his Website YOUR DNA 360 REPORT + ONE-ON-ONE CONSULTATION    Enjoyed This Podcast? If you did, subscribe and share it with your friends! Post a review and share it! If you enjoyed tuning in, then leave us a review. You can also share this with your family and friends so they can discover the benefits of an infrared sauna. Have any questions? You can contact me through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts. To pushing the limits, Lisa    

Helen Blau is a stem cell biologist and expert in why, as we age, our muscles weaken, even if we get exercise and try to stay fit. In an age when humans are living longer, our muscles are critical to living life to the fullest and Blau is helping them keep pace by recruiting stem cells to regenerate youthful muscle in older people.Join us on this episode of Stanford Engineering's The Future of Everything podcast as Blau and host Russ Altman discuss the science of muscle regeneration.

When we talk about living healthier for longer we must also include oral health, which plays a crucially important role in physical and mental health. According to the World Health Organization, over a billion people worldwide (~20% of the human population) experience trauma to their teeth at some point in their life, which can lead to tooth loss and lower quality of life.Current treatments are costly, lengthy, and often require additional procedures throughout the patient's life, which can be financially and emotionally draining.Scientists working on the dental regeneration technology (known as "Biotooth") aim to create a treatment that could regenerate your damaged or lost tooth using your stem cells.We talk all about Biotooth with none other than Dr. Paul Sharpe, who is one of the pioneers and leaders in this field.Dr. Paul Sharpe is head of the Department of Craniofacial Development and Stem Cell Biology at the historic King's College London, which is a wellspring of biomedical pioneers and innovation. As department head, Dr. Sharpe leads multiple academic research groups consisting of world-class biomedical researchers aiming to unravel the causes of diseases and translate discoveries into treatments to improve health worldwide.Dr. Sharpe's research focuses on the molecular control of tooth development, dental stem cell biology, and stem-cell-based therapies in clinical dentistry. He's been at this for 30 plus years and counting, publishing over 300 research papers to date.In 2004 Dr. Sharpe was awarded the Craniofacial Biology Research Award by the International Association for Dental Research, in recognition of his contribution to the understanding of how teeth develop. There's no one else better to talk with about this amazing Biotooth technology, which has the potential to restore smiles and improve an incredible amount of lives.In this interview with Dr. Sharpe, we focus on how Biotooth came to be, its current status, where it's headed in the near future, and what needs to happen for it to become a clinical treatment.For all questions related to Biotooth and Dr. Sharpe's work, please send all questions and comments to our team here: https://bit.ly/3tHEIKRConnect with Further Health-WEBSITE: https://furtherhealth.org-TWITTER: https://twitter.com/further_health-INSTAGRAM: https://www.instagram.com/furtherhealthproject/-YOUTUBE: https://bit.ly/2XpwdIGSupport this podcast at — https://redcircle.com/further-health-podcast/exclusive-content

It's typical for athletic performance to decline with age. (And, athletes may experience signs of accelerated aging caused by intense training.) If you're worried about your declining performance, start looking at how you train and what you eat. We may not be able to reverse our chronological age, but we can guide our bodies through the ageing process.  Did you know that there are longevity strategies specifically for athletes? These strategies consider long-term performance, health, and muscle growth!  In this episode, Dr. Elena Seranova joins us to discuss how ageing can affect our bodies and our athletic performance. She shares her strategies, from supplements to lifestyle changes, that can help athletes combat the effects of ageing. If you're overwhelmed by all of the information out there, remember: you need to build a good foundation first. Start with eating right and sleeping well; from there, you can eventually incorporate Dr. Elena's other recommendations. If you want to learn longevity strategies for athletes and how to improve athletic performance, then this episode is for you! Here are three reasons why you should listen to the full episode: Discover how ageing affects athletic performance and why athletes may experience signs of accelerated ageing.  Learn longevity strategies that will support athletic performance and your general health, like how to activate your autophagy pathways. Understand that longevity is a process of building good habits; you can start out by focusing on the basics, like diet and sleep.  Get Customised Guidance for Your Genetic Make-Up For our epigenetics health programme, which is all about optimising your fitness, lifestyle, nutrition and mental performance for your particular genes, go to  https://www.lisatamati.com/page/epigenetics-and-health-coaching/. Customised Online Coaching for Runners CUSTOMISED RUN COACHING PLANS — How to Run Faster, Be Stronger, and Run Longer  Without Burnout or Injuries Have you struggled to fit training into your busy life? Maybe you don't know where to start, or you have done a few races but struggle with motivation or injuries? Do you want to beat last year's time, or finish at the front of the pack? Do you want to run your first 5-km, or run a 100-miler? ​​Do you want a holistic programme that is personalised & customised to your ability, goals, and lifestyle?  Go to www.runninghotcoaching.com for our online run training coaching. Health Optimisation and Life Coaching Are you struggling with a health issue and need people who look outside the square and are connected to some of the greatest science and health minds in the world? Then reach out to us at support@lisatamati.com, we can jump on a call to see if we are a good fit for you. If you have a big challenge ahead, are dealing with adversity or want to take your performance to the next level and want to learn how to increase your mental toughness, emotional resilience, foundational health, and more, contact us at support@lisatamati.com. Order My Books My latest book, Relentless, chronicles the inspiring journey about how my mother and I defied the odds after an aneurysm left my mum, Isobel, with massive brain damage at age 74. The medical professionals told me there was absolutely no hope of any quality of life again. Still, I used every mindset tool, years of research and incredible tenacity to prove them wrong and bring my mother back to full health within three years. Get your copy here: https://shop.lisatamati.com/collections/books/products/relentless. For my other two best-selling books Running Hot and Running to Extremes, chronicling my ultrarunning adventures and expeditions all around the world, go to https://shop.lisatamati.com/collections/books. Lisa's Anti-Ageing and Longevity Supplements  NMN: Nicotinamide Mononucleotide, an NAD+ precursor Feel Healthier and Younger* Researchers have found that Nicotinamide Adenine Dinucleotide or NAD+, a master regulator of metabolism and a molecule essential for the functionality of all human cells, is being dramatically decreased over time. What is NMN? NMN Bio offers a cutting edge Vitamin B3 derivative named NMN (beta Nicotinamide Mononucleotide) that can boost the levels of NAD+ in muscle tissue and liver. Take charge of your energy levels, focus, metabolism and overall health so you can live a happy, fulfilling life. NMN Bio offers pure supplements that are rigorously tested by an independent, third-party lab. Start your cellular rejuvenation journey today. Support Your Healthy Ageing We offer powerful third-party-tested NAD+ boosting supplements so you can start your healthy ageing journey today. Shop now: https://nmnbio.nz/collections/all NMN (beta Nicotinamide Mononucleotide) 250mg | 30 capsules NMN (beta Nicotinamide Mononucleotide) 500mg | 30 capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 250mg | 30 Capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 500mg | 30 Capsules Quality You Can Trust — NMN Our premium range of anti-ageing nutraceuticals (supplements that combine Mother Nature with cutting edge science) combats the effects of ageing, and is designed to boost NAD+ levels. Manufactured in an ISO9001 certified facility. Boost Your NAD+ Levels — Healthy Ageing: Redefined Cellular Health Energy & Focus Bone Density Skin Elasticity DNA Repair Cardiovascular Health Brain Health  Metabolic Health Episode Highlights [02:32] Why Athletic Performance Drops as We Age The main cause of athletic performance decline is mitochondrial decline. Mitochondrial decline is linked to senescence cells.  Senescence cells stop dividing and do nothing. As we age, we may have 5-20% senescence cells in different tissues.  This causes inflammation and causes the mitochondria to function improperly, thus increasing reactive oxygen species within cells.  Nuclear DNA is usually packed in histones, which preserve genetic material. However, mitochondrial DNAs lack histones, making it prone to oxidative stress and mutations.    As we age, our epigenetic processes become less efficient; it becomes a vicious cycle with more reactive oxygen species and less capacity to deal with them.  [08:23] How Else Do Our Bodies Respond to Ageing Ageing declines autophagy, which recycles cellular organelles.  When there's nothing to clean up dysfunctional mitochondria, problems with energy generation arise. Athletes who have exercised intensely their whole life will have worn-off tissues and lactic acid buildup.  Remember, exercise is good, since we want some level of oxidative stress; however, we don't want more oxidative stress than what our body can cope with.  Lisa shares how running ultramarathons accelerated her ageing process, wear and tear, and inflammation.  [12:29] How to Support Autophagy and Athletic Performance?  Intermittent fasting is when people have a certain feeding window a day. After eating, mTOR switches off and AMPK is activated which allows for autophagy.   If you want to build muscle, Dr. Elena recommends eating after exercising so you can activate mTOR which helps with muscle growth.    You need to create a cycle going of mTOR and AMPK since autophagy recycles cells back into amino acids, which can help cells build new proteins.  Don't create a feeding window that's too narrow; you need to have enough fuel for your body. Eat chicken, meat, and foods rich in amino acids.  Make sure you're sleeping properly, as this can affect your muscle growth.  [18:30] Supplements to Support Autophagy and Longevity You can also support autophagy through supplements like berberine.  Dr. Elena recommends adding supplements to specifically target senescence cells. Senolytics help kill senescence cells while senomorphics modify the senescence cells.  Quercetin added with Vitamin C can help kill senescence cells. By itself, quercetin can produce toxic metabolites, so it needs Vitamin C to serve as an antioxidant.  She also recommends taking their quercetin product with NAC and acetylcysteine to boost glutathione, a potent antioxidant.  Quercetin has many benefits including anti-inflammatory properties, and can be used to combat cardiovascular disease, fight seasonal allergies, and can fight cancer.     [26:51] How to Take Quercetin Quercetin can be found naturally in fruits and vegetables like strawberries and onions.  If you've never taken compounds for their senescent action before, start by taking quercetin at 500 mg every day. After a month of taking it, check in on how you feel.  You can also implement detox protocols with a higher dosage of quercetin(around 2 - 2 ½ grams). If you want to implement this protocol, start with 5 days first.  Quercetin can be combined with 500mg of chlorella to boost the detoxifying reaction. People with kidney diseases should consult with a doctor before taking quercetin.   [32:43] How NMN Can Help Athletes  In addition to mitochondrial decline, athletes can experience loss of endurance and muscle loss as they age.  Dr. Elena recommends increasing your fasting window depending on your goals.  You want more oxygenation in your tissues to preserve endurance and muscle.  Dr. Elena offers an NMN product that can increase both endurance and prevent age-related muscle loss.    This can help increase insulin sensitivity, activating longevity genes and DNA repair.  [36:37] How to Optimise NMN  NMN functions optimally when it's attached to a methyl group. Unfortunately, our body's methylation process also declines with age.  NMN should be paired with TMG, as it is a rich methyl donor.  When you combine NMN, TMG, and quercetin, you'll optimise your performance and endurance. [39:11] Longevity is Your Biological Age, Not Your Chronological Age Many people over 40 are insulin resistant. Insulin resistance is a gateway to biological decline.  You can check your insulin resistance by checking your waist to hip ratio.  After the age of 40, it's much easier to experience hormonal dysfunction.  We need to make a conscious effort to improve our health. Ageing can cause issues to spiral if left uncontrolled.   [42:50] Be Careful With Your Food 80% of adults in the west are insulin resistant.  The food industry worsens the condition by offering so many processed carbohydrates.  Many people have false ideas about what a healthy diet is. You can't have too many carbohydrates and sugar, even if they're coming from fruits.  Cut down on carbohydrates, avoid processed foods, and take good oils.  [45:21] Start with the Basics Start with the basics. You don't need to add supplements immediately.  Just eat clean and good food. There's no such thing as a universal diet.  Taking cold showers in the morning can improve hormonal balance. You can start with just 10 seconds of cold exposure.  Manage your stress levels and make sure you move regularly.  You don't need to be perfect.  [50:47] How Some People Live to 100  There were two hypotheses surrounding centenarians: good habits and the absence of high-risk genes. However, some centenarians were found to have bad habits and mutations for Alzheimer's disease.  Centenarians have genes that mitigate risks from bad mutations. They also have low IGF 1 levels.  When people are young, IGF 1 can improve muscle and tissue growth, but it can be harmful when people grow older. Centenarians' genetic combination allowed for IGF to decrease as they grow older. Listen to the episode to learn more about how centenarians' hormonal processes are being regulated. Commit to regularly regulating and balancing your hormones. This process starts with clean food, caloric restriction, and exercise.     About Dr. Elena Dr. Elena Seranova is a scientist, serial entrepreneur, and business mentor. She has now founded multiple innovative biotechnological businesses. She first studied at the University of Ioannina with a major in Psychology. Dr. Elena then started a private practice before developing an interest in neuroscience. Dr. Elena continued her studies and earned her Master's Degree in Translational Neuroscience at the University of Sheffield. She now also holds a Doctorate Degree in Stem Cell Biology and Autophagy from the University of Birmingham. Dr. Elena's expertise in these fields led her to co-found the biotech start-up SkyLab Bio. She has written several peer-reviewed articles on autophagy. Her latest business is NMN Bio. Her own experiences with supplements have inspired her to expand the market to include cutting-edge anti-ageing supplements. NMN Bio reaches New Zealand, the UK, and Europe. Dr. Elena found her passion for drug discovery and autophagy. She has endeavoured to share this with the public through her research and work as an entrepreneur.  To learn more about Dr. Elena and her work, visit NMN Bio. Resources Gain exclusive access and bonuses to Pushing the Limits Podcast by becoming a patron!  Want to learn more from Dr Dom? Check out our previous episode with her:  Episode 238 - Reverse Ageing to Live Longer and Healthier with Dr. Elena Seranova Episode 189: Understanding Autophagy and Increasing Your Longevity with Dr Elena Seranova  Episode 183: Sirtuins and NAD Supplements for Longevity with Dr Elena Seranova        Want to dive deeper into longevity and work out a protocol for yourself? Take the Foundations of Longevity and Life Extension Online Course by Dr Elena Seranova and Jesse Coomer  Deep Nutrition: Why Your Genes Need Traditional Food by Catherine Shanahan, M.D.  Centenarians, metformin, and longevity | Nir Barzilai, M.D., Episode 204 from the Peter Attia podcast  Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38 Therapeutic Potential of Quercetin: New Insights and Perspectives for Human Health Visit NMN Bio to know more about NMN supplements!  

Rong Lu is an associate professor of stem cell biology and regenerative medicine, biomedical engineering, medicine, and gerontology at USC. She joins George Shannon to discuss her research into the complex and surprising behavior of individual blood stem cells and what it could mean for treating diseases associated with aging. Quotes from this episode On stem cells and what makes them so promising for medical research Stem cells are the special cells in the body that can produce other type of cells. So in particular there are two type of stem cells, one called embryonic stem cells that only exist in the embryonic stages. And the other type of stem cells are called somatic stem cells that are also exist in adulthood. And these somatic stem cells can produce only a specific subset of the cell types in the body. For example, skin stem cells can only produce skin cells and blood stem cells can only produce blood and immune cells. But all the stem cells share the general special property called self-renewal and differentiation. So differentiation describes their ability to produce a different type of cells and self-renewal refers to their ability of making more of themselves over time and sustain the long-term differentiation and tissue regeneration. On the ability of stem cells to regenerate as we age …that's what makes stem cells super special because they are the only long-lasting cells in the body that continuously regenerate and sustain the tissue. But over time, stem cells capacity in terms of self-renewal are reducing and therefore the tissue as homeostasis decline when the body ages. On whether stem cells might offer protection against age-related immune decline Sure. So over aging stem cells become less and less competent in producing immune cells. And, the hope is if we can maintain the stem cells capacity over time then we could make the stem cells offer the protection. Again, this is very much a research in progress and many research labs are working on this important question, including my own lab. On the focus of research in her lab In our lab, we're interested in understanding how are individual stem cells different from each other and how different stem cells work together to maintain an overall balanced blood pool. And in particular, over aging, we want to understand how individual blood stem cells change during aging and how their change lead to the aging phenotype of the animal. And what we found is that there are a specific subset of blood stem cells that age, particularly faster than the others. And there's also another group of stem cells that actually can change in the opposite way during aging and provide more immune cells and their presence really correlate with the delayed aging phenotype of the animal. So we're very excited about this finding and we're following up on this study using our bar coding tool to track these anti-aging stem cells and study what make them so special. On the development and use of a tool to label individual cells with unique “barcodes”  The barcoding tool was developed a couple of decades ago by several labs simultaneously. At that time they used the viral insertion site as a marker to track individual cells. So about 10 to 20 years ago, high throughput sequencing technology started to emerge. And at that time,  I started to combine the new capacity of this high throughput sequencing to quantify the cellular behavior at a single cell level. So instead of using viral insertion site, I provide a particular DNA barcode sequence into the virus and use that as a marker to track individual cells. And what this allow us is a high precise quantification of the cellular behavior and also the high throughput that is needed to track hundreds and thousands of stem cells in the body. We can use this tool to study cancer cells and understand the heterogeneity among individual cancer cells. For example, a recent study from my group used it to track the primary acute lymphoblastic leukemia cells in xenograph mouse model. And what we found is that individual leukemia cells have different ability to grow to metastasize and to respond to the drug treatment. And we found that some cancer stem cells that are particularly resistant to drugs to drug treatment In particular, some leukemia cells that are particular resistant to chemotherapy treatment, exhibit distinct gene expression signature compared to others. On gene expression signatures The gene expression signature means these particular subset of cells express a distinct subset of genes that make them different and potentially may cause their specific drug response behavior. So these particular gene expression signature can allow us first to identify these cells and to detect whether these cells exists and whether the patient has the potential of resist chemotherapy. And secondly, these gene expression signature can also be potential drug treatment targets to allow us to particularly target these cancer or leukemia cells in the therapeutic treatment. On future directions in aging research So in the context of aging, we are very excited about our recent discovery of these anti-aging, uh, stem cells. And we would like to further understand how to activate these anti-aging behavior and how to expand their function in the animal. And we are also very excited about our discovery on the cellular heterogeneity in disease, in particular, in their response to chemo drug treatment. And we would like to further identify the potential functions of the gene expression signature that we discovered. In addition, we also want to understand whether the microenvironment of the stem cell play a role in terms of instructing their heterogeneous behavior.

This content was recorded during a Retina UK webinar on Thursday 28 April 2022. You can watch the full version, which includes slides, on our YouTube channel: https://www.youtube.com/c/RetinaUK. This webinar will be presented by Avril Watson. Avril is a PhD candidate of Stem Cell Biology in Professor Majlinda Lako's group at Newcastle University and also a Scientist at Newcells Biotech Ltd. She is funded through the Marie Curie Actions project StarT which focuses on diagnosis, treatment and modelling of Stargardt disease. Her research is focused on modelling Stargardt disease with mini-retinas generated from patients with late-onset Stargardt disease. Avril has always had an interest in retinal disease and has worked in various retinal research groups in Ireland before moving to the UK to continue her studies. Aside from her interest in retinal research, Avril plays guitar, loves to swim and is a big fan of dogs! Inherited retinal disorders affect nearly one in 2,000 people in the world. Despite such a high frequency, there are limited treatment options available. There are a number of factors responsible for this. One of the main issues is the difference in early symptoms and also in the progression of disease over time, even in cases where individuals have the same genetic diagnosis. Considering this, each case of retinal blindness turns out to be quite rare, and so it can be difficult to make personalised medicine for each and every person. The trick is to identify common symptoms between different retinal diseases, so that the therapy can be used to help as many people as possible. However, this is easier said than done! With the help of mini-retinas, we can study these diseases in a patient-specific manner and on a much more in-depth scale. Mini-retinas are essentially mini eyeballs in a dish. They contain all of the cell types in the human retina and we can perform many experiments on these to figure out the missing pieces in the puzzle. This allows us to identify new patterns in retinal disease that drugs can later be developed for. As mini-retinas are very similar to the real thing in human, we can also use them to test out these new treatments to ensure that they do what they're supposed to. This testing strategy allows therapies to proceed through all the regulatory processes quicker and with more confidence so that they can be one step closer to being used in the clinic to prevent/treat vision loss. In this webinar, Avril will discuss some of the existing therapies available for retinal disease, and some that are being developed for a number of different retinal conditions, highlighting how mini-retina are important in the drug development process.

No one is exempt from ageing, and with aging comes diseases and sickness. Decreased performance and cell production also occur because of this phenomenon. Lifestyle changes may be inadequate to help your body function properly. Over the past years, longevity science has been evolving, with the emergence of several anti-ageing supplements in the market. However, the body may not absorb these supplements effectively enough to slow down the effects of ageing. In this episode, Dr Elena Seranova explains how the ageing process works. She details how to use supplements, complemented by lifestyle changes, to reverse ageing. She also shares how NMN can be coupled with TMG to create the ultimate longevity supplement. There's no one supplement to optimise your health, but good habits and lifestyle changes are integral to having a longer and healthier life! If you want to learn how to reverse ageing through supplements and lifestyle changes, then this episode is for you! Here are three reasons why you should listen to the full episode: Understand the aging process, its vicious cycle, and how it affects and changes our bodies.  Learn how you can slow down and reverse the effects of aging. Discover how you can combine TMG with NMN for better results. Get Customised Guidance for Your Genetic Make-Up For our epigenetics health programme, all about optimising your fitness, lifestyle, nutrition and mind performance to your particular genes, go to  https://www.lisatamati.com/page/epigenetics-and-health-coaching/. Customised Online Coaching for Runners CUSTOMISED RUN COACHING PLANS — How to Run Faster, Be Stronger, Run Longer  Without Burnout & Injuries Have you struggled to fit in training in your busy life? Maybe you don't know where to start, or perhaps you have done a few races but keep having motivation or injury troubles? Do you want to beat last year's time or finish at the front of the pack? Want to run your first 5-km or run a 100-miler? ​​Do you want a holistic programme that is personalised & customised to your ability, goals, and lifestyle?  Go to www.runninghotcoaching.com for our online run training coaching. Health Optimisation and Life Coaching Are you struggling with a health issue and need people who look outside the square and are connected to some of the greatest science and health minds in the world? Then reach out to us at support@lisatamati.com, we can jump on a call to see if we are a good fit for you. If you have a big challenge ahead, are dealing with adversity or want to take your performance to the next level and want to learn how to increase your mental toughness, emotional resilience, foundational health, and more, contact us at support@lisatamati.com. Order My Books My latest book Relentless chronicles the inspiring journey about how my mother and I defied the odds after an aneurysm left my mum Isobel with massive brain damage at age 74. The medical professionals told me there was absolutely no hope of any quality of life again. Still, I used every mindset tool, years of research and incredible tenacity to prove them wrong and bring my mother back to full health within three years. Get your copy here: https://shop.lisatamati.com/collections/books/products/relentless. For my other two best-selling books Running Hot and Running to Extremes, chronicling my ultrarunning adventures and expeditions all around the world, go to https://shop.lisatamati.com/collections/books. Lisa's Anti-Ageing and Longevity Supplements  NMN: Nicotinamide Mononucleotide, an NAD+ precursor Feel Healthier and Younger* Researchers have found that Nicotinamide Adenine Dinucleotide or NAD+, a master regulator of metabolism and a molecule essential for the functionality of all human cells, is being dramatically decreased over time. What is NMN? NMN Bio offers a cutting edge Vitamin B3 derivative named NMN (beta Nicotinamide Mononucleotide) that can boost the levels of NAD+ in muscle tissue and liver. Take charge of your energy levels, focus, metabolism and overall health so you can live a happy, fulfilling life. Founded by scientists, NMN Bio offers supplements of the highest purity and rigorously tested by an independent, third-party lab. Start your cellular rejuvenation journey today. Support Your Healthy Ageing We offer powerful third-party tested NAD+ boosting supplements so you can start your healthy ageing journey today. Shop now: https://nmnbio.nz/collections/all NMN (beta Nicotinamide Mononucleotide) 250mg | 30 capsules NMN (beta Nicotinamide Mononucleotide) 500mg | 30 capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 250mg | 30 Capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 500mg | 30 Capsules Quality You Can Trust — NMN Our premium range of anti-ageing nutraceuticals (supplements that combine Mother Nature with cutting edge science) combats the effects of aging while designed to boost NAD+ levels. Manufactured in an ISO9001 certified facility Boost Your NAD+ Levels — Healthy Ageing: Redefined Cellular Health Energy & Focus Bone Density Skin Elasticity DNA Repair Cardiovascular Health Brain Health  Metabolic Health My  ‘Fierce' Sports Jewellery Collection For my gorgeous and inspiring sports jewellery collection, 'Fierce', go to https://shop.lisatamati.com/collections/lisa-tamati-bespoke-jewellery-collection. Episode Highlights [01:53] How Longevity Science Is Growing There are a growing number of anti-ageing products as we understand the ageing process better. Multiple cellular processes decline or become imbalanced as people age. There are 9 hallmarks of ageing, and the study recently added another hallmark to include inflammation.  The top four killer diseases are cancer, cardiovascular disease, neurodegeneration, and diabetes. The older you are, the higher your chance of developing one of these diseases.  Our body peaks at 25 and starts the aging process from there. [06:06] Why Is NMN Important?  NMN stands for nicotinamide mononucleotide and is a Vitamin B3 derivative.  It's a natural molecule that you can get from food, but getting an efficient dosage requires supplementation. NMN is a precursor to help our metabolism, and it boosts NAD levels. NAD serves as fuel for SIRTUIN proteins that are involved in rejuvenation processes.  NAD is vital to keep our cells healthy and ensure they don't lose their identity. [09:23] What Happens in the Body as We Age Cell identity is vital. What differentiates cells is how certain parts of the genomes are read. As we age, this process can become chaotic.  Chromatin is a substance in a chromosome. Lightly packed chromatin under active transcription is called euchromatin. Heterochromatin, on the other hand, is more condensed and transcriptionally silent. Epigenetic changes can dictate which areas will be active or inactive. This defines how a cell can be expressed. Sirtuins are crucial in making sure the right genes are active and mediating DNA repair. However, they become less efficient as we age.  This is how our epigenetic regulation becomes loose, leading to genomic instability and loss of cellular identity.  [15:33] How Aging Can Create a Vicious Cycle NAD is the fuel source of sirtuin genes. When these genes are depleted, our DNA can't be repaired. As we age, NAD production depletes. DNA breaks and genome instability also increase.  This becomes a vicious cycle of needing more energy but with less production.  Furthermore, genome instability can increase senescence or zombie cells. These can further increase genome instability.  Senescent cells are cells that forget how to do their function well and stop replicating. These cells can further drain NAD levels. [18:19] The Link Between Fasting and Cell Autophagy Autophagy is the process where cells can get rid of toxins and other things that are not needed anymore. Autophagy ensures housekeeping and can be triggered by fasting.  12 hours of fasting can start autophagy in the liver, while 20 hours of fasting can start the process in other tissues.    Eating can activate mTOR, which is another vital cell regulator. This process is deactivated through supplements like Berberine. Learn to balance both eating and fasting. Hear about Dr Elena's fasting schedule and supplements in the full episode! [27:48] Why Dr Elena Launched TMG Methylation is vital for the body's most critical functions. These include creating neurotransmitters, cell division, energy production, metabolism, and epigenetics.  Dr Elena launched TMG to boost NMN's effectiveness and metabolism.  Methylation and TMG can control homocysteine levels, which correlate with cardiovascular diseases. TMG may also enhance athletic performance. It also has a good safety profile with no side effects despite higher dosage. Dr Elena recommends a 1:2 or 1:3 ratio of NMN to TMG. For every 500 milligrams of NMN, take 1 to 2 grams of TMG. [33:31] Do We Need to Worry about Hyper-methylation?  It's difficult to hyper-methylate. However, individual genetic factors can affect homocysteine levels.  To check your homocysteine levels, you can undergo a blood test or check your gene variants with a genetic test TMG is an osmoregulator that helps regulate cell balance and can optimize methylation. After taking over 20 grams, a laxative effect may appear. [39:41] Where to Start Dr Elena recommends taking NMN, TMG, and extra virgin olive oil for anti-ageing. NMN can also help increase insulin sensitivity and boost collagen production, as seen in human clinical trial in prediabetic women. The market has a lot of collagen supplements, but not all of them are absorbed by the body effectively. Insulin sensitivity decreases as we age. This is the body's ability to let glucose flow freely into cells. You can reverse ageing problems with a better lifestyle and supplements. Dr Elena recommends avoiding carbohydrates in your diet. [42:55] How to Have a Healthier Diet Around 80% of adults in the West may be pre-diabetic. So many foods nowadays are made to be addictive.  While a vegan diet can help you detox at first, you will eventually experience amino acid depletion. Dr Elena prefers a carnivore diet. She also does fasting with a three-hour eating window. You can start with a longer eating window and slowly reduce it.  You don't want a glucose spike in the morning. [48:06] You Don't Need to Be Perfect  You don't have to be perfect every day, but make sure you stay consistent with your overall longevity routine.  Exercise and saunas activate Sirtuins. Try to have a routine for one or both. Optimize your routine and find out what works for you.  [50:52] NMN Bio's Growth Dr Elena shares that her company has been growing rapidly. They now have a UK warehouse, UK Amazon FBA, and another warehouse in Europe.  They are also expanding to the United States.  Remember that no one supplement will do everything for you. You also need to change your lifestyle, which includes diet, exercise, and even biorhythms.   There's a lot of information about longevity online, and it can become overwhelming. This is why Dr Elena created an online course about longevity.  Dr Elena recommends making sure your circadian rhythm is not disrupted.  Resources Gain exclusive access and bonuses to Pushing the Limits Podcast by becoming a patron! Tune in to more Pushing the Limits episodes on health and ageing! Episode 231: The Immune System and How It Fights Cancer Cells and Viruses with Dr Elizabeth Yurth  Episode 196: Rethinking the Function of Mitochondria for Our Health with Dr Elizabeth Yurth  Episode 189: Understanding Autophagy and Increasing Your Longevity with Dr Elena Seranova  Episode 187: Back to Basics: Slow Down Ageing and Promote Longevity with Dr Elizabeth Yurth Episode 183: Sirtuins and NAD Supplements for Longevity with Dr Elena Seranova  Want to dive deeper into longevity and work out a protocol for yourself? Take the Foundations of Longevity and Life Extension Online Course by Dr Elena Seranova and Jesse Coomer  The Ultimate Anti-Aging Combination: TMG & NMN to Live Significantly Longer? By NMN Bio  The Hallmarks of Aging  Nicotinamide Mononucleotide Increases Muscle Insulin Sensitivity in Prediabetic Women Visit NMN Bio to know more about NMN supplements!      Lifespan by Dr David Sinclair    7 Powerful Quotes [04:28] ‘The older you are, the highest your risk of getting one of these diseases; so if it's not gonna be one of them, it's gonna be the other one… Now we start realising when does aging start, which is actually at quite a young age, basically at the age of 25. Because this is where our hormones peak…' [12:25] ‘There are multiple functions that Sirtuins need to attend to within the cell. With age, this function becomes less and less efficient, basically, because sirtuins become more forgetful.' [16:02] ‘So as we age, the production of NAD is declining. So this means that there is less NAD available for sirtuins to use as their fuel to do their job.' [39:52] ‘There are so many collagen supplements on the market, but not all of them are efficient. And actually not all of them are being absorbed properly because when you do take collagen orally, basically, it's broken down into amino acids in your digestive system. And then those amino acids may or may not be used to produce more collagen.' [47:56] ‘We're all on this road of re-educating ourselves and don't go for perfection. Just go for better, I think is a message as well, you don't have to be perfect.' [52:22] ‘With regards to the longevity field, I think that it's very important for people to understand that there is no such thing as the fountain of youth. There is no one supplement that you're going to take that is going to do everything for you.' [56:40] ‘If your melatonin is disrupted, then you will have less defense against reactive oxygen species and that there is another plethora of processes that melatonin is also implicated in and then you don't have all these benefits. And then you're basically aging faster… Takeaway message from today's podcasts. Make sure that you go to sleep early, everyone.' About Dr Elena  Dr Elena Seranova is a scientist, serial entrepreneur and business mentor. She has now founded multiple innovative biotechnological businesses. She first studied at the University of Ioannina with a major in Psychology. Dr Elena then started a private practice before developing an interest in neuroscience. She continued her studies and earned her Master's Degree in Translational Neuroscience at the University of Sheffield. She now also holds a Doctorate Degree in Stem Cell Biology and Autophagy from the University of Birmingham. Dr Elena's expertise in these fields has led her to become the co-founder of a biotech start-up, SkyLab Bio. She has written several peer-reviewed articles on autophagy throughout her career. In addition to these accomplishments, she started her latest business, NMN Bio. Her own experiences with the use of supplements have inspired her to expand the market to supply the public with cutting-edge anti-ageing supplements. NMN Bio reaches New Zealand, the UK, and Europe. Dr Elena found her passion for drug discovery and autophagy. She has endeavoured to share this with the public through her research and work as an entrepreneur.  To learn more about Dr Elena and her work, visit NMN Bio. Enjoy The Podcast? If you did, be sure to subscribe and share it with your friends! Post a review and share it! If you enjoyed tuning in, then leave us a review. You can also share this with your family and friends so they can know how to optimise sleep.  Have any questions? You can contact me through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts. To pushing the limits, Lisa  

Dr. Kelly McNagny is a Professor of Medical Genetics and Biomedical Engineering at the University of British Columbia. His research program is focused on hematopoietic stem cell biology, specifically in understanding the signaling networks that regulate stem cell differentiation and how these cells interact with their microenvironment. He talks about how hematopoietic stem cell differentiation is related to chronic inflammatory disorders, targeting glycosylation in solid tumors, and his international career path.

Dr. Kenta Nakamura joins us on this week's episode to discuss the history of stem cell research and how he plans to help lead it into the future.   His educational foundation in stem cell biology has intersected with an interventional clinical focus at UW Medicine to now lead a new clinical trial with human vascular endothelial growth factor (VEGF) to induce therapeutic angiogenesis (revascularization).  Episode topics:0:38 - Stem Cell Biology and Interventional Cardiology Career3:55 - Rocky Road of Stem Cell Therapies 9:25 - Thoughtful process of new clinical trials10:20 - Techniques and delivery of stem cells17:50 - Diagnostically measuring success21:43 - EXACT Clinical Trial - Refractory Angina 26:20 - Patient Criteria32:20 - Potential for Young Patients 37:29 - Motivation for Medicine39:47 - Advice for Translational Basic Science Careers43:28 - Outside of work45:50 - Referrals for Trialhttps://clinicaltrials.gov/ct2/show/NCT04125732@KentaMDnakamur@uw.edu

Today's guest is Dr. Thomas Rando, Professor, Neurology; Molecular, Cell and Developmental Biology, and a pioneer in stem cell biology and the biology of aging. Dr. Rando is the Director of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at the University of California, Los Angeles, and the co-founder and Chair of the Board of Directors at Fountain Therapeutics. In today's episode, he shares information surrounding cell cycle, parabiosis, and replacement therapy. Dr. Rando begins by explaining why the cell cycle is important and the place of aging cells in the world of cell cycle. He explains the quiescent states of cells and how heterochronic parabiosis has been tested on animals to determine if cells in a younger animal can be used to activate those in an older animal. He also discusses how three factors impact aging: genetics, diet, and exercise. In this episode, you'll learn the meaning and importance of cell cycle and parabiosis and how they both relate to aging. Episode Highlights: Dr. Rando's transition from neurology to stem cell biology The importance of cell cycle Why aging cells do not repair tissues Exploring the quiescent state How heterochronic parabiosis works Chronic inflammation in older people Does exercise benefit the tissues in the body? The connection between exercise and replacement therapy The relation between diet and longevity What are ketogenic diets? Dr. Rando's thoughts on supplementation The future of stem cell therapy Can bone marrow be used to rejuvenate older people? Can stem cell therapy treat Alzheimer's disease? Transitioning from an academic to a founder Quotes: “Why is it that we heal our injuries and wounds less well as we age?” “The older we get, the more difficult it is to activate these cells out of that state. And you can imagine that if a cell is dormant, and you can't wake it up, it's not going to do very well in terms of repairing tissues.” “There's no free lunch here. What benefits the old animal hurts the young animal.” “The only reason why a species survives and thrives and continues is because of reproduction.” “No one wants to calorically restrict for their whole life. I mean, no one wants to go through their life eating 30%.” “Anything that we can do to find a healthy diet that is palatable and sustainable, and prevents obesity will be a good thing.” Links: Email questions, comments, and feedback to podcast@bioagelabs.com Translating Aging on Twitter:https://twitter.com/BioAgePodcast ( @bioagepodcast) BIOAGE Labs Websitehttps://bioagelabs.com/ ( BIOAGELabs.com) BIOAGE Labs Twitterhttps://twitter.com/bioagelabs?lang=en ( @bioagelabs) BIOAGE Labshttps://www.linkedin.com/company/bioage-labs/ ( LinkedIn) https://fountaintx.com/ (Fountain Therapeutics)

Mark a geneticist with PhD in Stem Cell Biology from Imperial College and founder of research data company figshare linked up with Aldo, the business guy and founder of EdTech company to launch Genomes. They added several other smart and talented team members, including the GenomesDAO Intern who brings experience in pharmacology and very excited about DAOs, NFTs and  the crypto world. Together this dynamic team is not only pushing the NFT space forward, but potentially the human race!Certainly not just another PFP project, tune into the show to find out how this team plans to change the world and head over to Genomes Discord to learn more about the $GENE and $GNOME tokens and one of the hottest new DAOs. dGen Networkhttps://dgen.network/https://twitter.com/dGenNetwork Show Mentions:https://twitter.com/GenomesDAOhttps://twitter.com/dazza9x Show Linkshttps://genomes.io/Discord.gg/genomes   The Ape and Pony Show is proud to be part of The dGen Network https://twitter.com/dGenNetworkhttps://dgen.network/     Swørn - Sorry https://chll.to/b851483fB.P. and his guests are not registered investment advisors. Nothing discussed should be relied on for investment decisions, nor is it investment advice. This show is solely for information and entertainment only. 

"Designer babies" have become a hot topic over the past few years, but to anyone who is familiar with CRISPR/Cas9 genome editing (or even those who have seen the 1997 film Gattaca) the concept of genetically modified babies is not a new one. In fact, the technology has been around for quite awhile. So why are "designer babies" making headlines now, what are they, and why are scientists so concerned? Tune in this week as we discuss with Güneş Taylor about the subject. Güneş Taylor is a Postdoctoral Training Fellow in the Lovell-Badge Lab at the Francis Crick Institute of London. The lab's work revolves around Stem Cell Biology and Developmental Genetics, and she's specifically looking at methods of sex-determination during development. Güneş has spoken many times on the subject of "designer babies" and will be sharing her views and ideas with us during this week's episode. Güneş is also a mental health first aider through her work and believes the two go hand in hand. Tune in to hear the interview and learn more about the interesting subject of CRISPR and designer babies!

Sponsored by Delight Cafe. Our guest, Nick Holdreith, works in Stem Cell Biology to improve treatments for blood-based diseases. He talks about research into that area, his take on COVID-19, and the paths he's taken as he attains a PhD. --- Send in a voice message: https://anchor.fm/thehpodcastcle/message

In this episode of La Verdad Duele Podcast, our guest Francis Aguisanda who graduated with his bachelor's degree from George Mason University and Master's degree in Stem Cell Biology from Stanford University opened up about mental health, and how he dedicates his free time as a crisis counselor with the National Suicide Prevention Hotline and Santa Clara County, CA Behavioral Health Services. Francis shared his personal experiences with mental health, the articles he has written about mental health in college campuses across the U.S and the necessary changes that must happen in these institutions. France has written articles about science, mental health, research, and many more. Francis' day job is at a Bay Area Biotech Company. A fascinating interview with a brilliant guest. Worth the listen! Our Social Media (IG): @laverdadduelepod Join Our Listserv: LVD Podcast Listserv Resources: Francis website @ https://www.aguisanda.com/ publications/articles can be found on his website.  Francis IG & twitter: @ atpandme

On this week's episode, I chat with Elena Seranova. Elena is from the UK and we met in a facebook group. I am so grateful for technology right now and its ability to connect us. Elena has a BSc in Psychology, MSc in Neuroscience, and is currently a Phd candidate in Stem Cell Biology. In the past Elena has ran a 6-figure wellness business and was a co-founder of a biotech start up. With her impressive resume and a wealth of knowledge, she shares her secrets on how she became so successful in her businesses. She also gives us a few books that have changed her life and they way she looks at business. Get ready to be inspired to go to the next level in your business!Make sure to visit www.olesyaoligradska.com/podcast for show notes, offers, and juicy details.For more inspo head over to Instagram and follow us @olesyaoligradska and @guiltofgrowth

As you age, your cells divide over and over again, leading to minute changes in their genomes. New research reveals that in the lining of the esophagus, mutant cells run rampant, fighting for dominance over normal cells. But they do this without causing any detectable damage or cancer. Host Sarah Crespi talks to Phil Jones, a professor of cancer development at the University of Cambridge in the United Kingdom, about what these genome changes can tell us about aging and cancer, and how some of the mutations might be good for you. Most Western farmers apply their pesticides using drones and machinery, but in less developed countries, organophosphate pesticides are applied by hand, resulting in myriad health issues from direct exposure to these neurotoxic chemicals. Host Meagan Cantwell speaks with Praveen Vemula, a research investigator at the Institute for Stem Cell Biology and Regenerative Medicine in Bengaluru, India, about his latest solution—a cost-effective gel that can be applied to the skin to limit pesticide-related toxicity and mortality. This week's episode was edited by Podigy. Download a transcript of this episode (PDF) Listen to previous podcasts. About the Science Podcast [Image:Navid Folpour/Flickr; Music: Jeffrey Cook]

Dr. Jalees Rehman is an Associate Professor of Medicine at the University of Illinois College of Medicine at Chicago. He is also a science writer for magazines including Aeon and Science Blogger with his own blog in the SciLogs called The Next Regeneration. He received his MD from the Medical School of the University of Munich and completed a postdoctoral fellowship in the Department of Medicine at the University of California San Diego. Jalees is here with us today to tell us about his journey through life and science.