Podcasts about TH1

Most people are told: "If you have thyroid antibodies, you have Hashimoto's. If you don't, you don't." In this episode, Dr. Eric Balcavage, creator of the Adaptive Thyroid Model™, revisits that idea and shows why antibodies are only one piece of a much bigger picture. Discover how: ✅ Th1 and Th17 T-cells, CD8 T-cells, and low T-regs drive thyroid inflammation and tissue damage ✅ PAMPs (pathogen signals) and DAMPs (cell-danger signals) can bind to pattern-recognition receptors [PRRs] on thyroid cells, triggering cytokines and interferon activity ✅ Antibodies may confirm Hashimoto's, but their absence doesn't rule it out (seronegative Hashimoto's is real) ✅ Addressing the drivers of immune imbalance — gut permeability, sleep debt, oxidative stress, nutrient deficiencies — can help restore tolerance and thyroid function Dr. Balcavage breaks down the latest research on how inflammation starts inside the thyroid, why the body isn't "attacking" itself, and what a true recovery plan looks like.

In this episode of Tea with Dr D, host James Q. Del Rosso, DO, is joined by Christopher Bunick, MD, PhD, and later Lisa Swanson, MD, for a deep look at phosphodiesterase-4 (PDE4) inhibition in dermatology, with a special focus on topical roflumilast.  Dr Bunick opens with a primer on the science of PDE4, an enzyme that degrades cyclic AMP (cAMP), an intracellular messenger that regulates anti-inflammatory pathways. In conditions such as atopic dermatitis (AD) and psoriasis, overactive PDE4 leads to reduced cAMP and amplified inflammation. By “gumming up” PDE4, roflumilast restores a more balanced, anti-inflammatory state.  He explains why PDE4 inhibition is relevant across multiple inflammatory pathways, including Th1, Th2, and Th17, and why roflumilast has demonstrated stronger efficacy than earlier inhibitors like crisaborole. Molecularly, roflumilast mimics cyclic AMP's binding to PDE4 across 3 key sites, producing far tighter binding than apremilast and crisaborole, which translates to superior clinical potency.  Dr Bunick illustrates this with a case of palmoplantar pustular psoriasis that cleared dramatically within 8 weeks on topical roflumilast after multiple biologic and corticosteroid failures, highlighting its durability and barrier-restoring properties. He and Dr Del Rosso contrast this with the limitations of chronic steroid use, noting that roflumilast supports long-term control without barrier compromise.  The discussion also touches on vitiligo, where Dr Bunick shares an early case of repigmentation following roflumilast treatment, suggesting possible cAMP-mediated stimulation of melanogenesis. They highlight the molecule's innovative aqueous-based formulation, optimized for skin-compatible pH and excellent tolerability.  In Part 2, Dr Swanson joins to discuss pediatric use. She reviews the 0.15% cream for AD in patients ≥6 years and the 0.05% cream for ages 2–5, both once-daily, steroid-free options that minimize burning and stinging compared with earlier PDE4 inhibitors. They review clinical data that demonstrate rapid itch relief, strong efficacy across IGA and EASI end points, and sustained control with twice-weekly maintenance.  Tune in to hear how PDE4 inhibition, and particularly topical roflumilast, is redefining nonsteroidal therapy across age groups and disease states in dermatology. 

We are not talking about gluten, dairy, sugar, or even leaky gut. We're talking about the silent saboteurs—the things that are messing with your gut health every single day... and no one's warning you about them.Join the 60 Day gut reset and transform your health! $200OFF with code 'SECRETOFFER! https://checkout.teachable.com/secure/1716725/checkout/order_q9s5bzn3?coupon_code=SECRETOFFERINSTA: @wholistichomeopath

#56. Ting som nevnes i denne episoden: aktivering av T- og B-celler. Effektorceller versus hukommelsesceller. Th1 vs Th2 vs Th17 vs. follikulære T-hjelpeceller. CD40 og CD40 ligand (CD40L). Antistoffproduserende celler (plasmablaster og plasmaceller). Opsonisering. Antistoffavhengig cellemediert cytotoksisitet (ADCC). Komplementmediert cytotoksisitet (CDC).Tredje sesong er muliggjort gjennom et stipend fra Norsk revmatologisk forening. Hosted on Acast. See acast.com/privacy for more information.

There's been a lot of talk about allergy symptoms becoming more severe over the last few years. What is contributing to this change? And more importantly, what can we do to control our environments and help support our bodies' immune systems? Our guest today is double-board certified physician and allergist, Dr. Tania Elliot. She's joining us for an insightful conversation on allergies and immunology. You're going to learn what allergies are and how they develop, why there's an explosion of allergies happening right now, and what the main root cause is. Dr. Elliot is going to unpack how to reduce allergy exposures and how your immune system works when allergens are present. You're also going to learn practical tips for optimizing your environment, including air quality, sleep practices, and how to travel as healthily as possible. Dr. Tania Elliot is a leading authority in this subject matter, and I know you're going to love this episode of The Model Health Show. Enjoy! In this episode you'll discover:  What Dr. Elliot's driving force for becoming a doctor was. (7:45) Why working in allergy and immunology is like being a detective. (9:57) What an allergy actually is. (11:59) The connection between allergies, autoimmunity, and inflammation. (12:27) Three main reasons why allergies are more prevalent today. (12:46) The interesting role of Th2 cells. (14:39) How c-section deliveries impact the baby's immune system. (16:25) Why peanut allergies have become more common. (18:34) What a histamine reaction is. (22:10) The difference between Th1 cells and Th2 cells. (22:18) What super pollen is. (24:32) How our indoor microbiome can influence allergies. (25:18) The 3 main things Dr. Elliot would never order in a restaurant. (29:24) What to avoid if you struggle with indoor allergies. (34:03) Why you should never let your pets on your bed. (36:20) What to avoid in a hotel room for better health. (38:33) The best sleep-supportive supplements. (43:49) How the humidity level in your bedroom affects allergies. (45:03) What the first line of treatment against allergies is. (46:45) Which foods have the highest histamine levels. (50:34)  Items mentioned in this episode include:  Foursigmatic.com/model - Get an exclusive discount on your daily health elixirs! Myessentia.com/model - Get a discount on organic, supportive mattresses! Healthy Home Guide - Read Dr. Tania Elliot's e-book! Connect with Dr. Tania Elliot Website / Substack / Instagram  Be sure you are subscribed to this podcast to automatically receive your episodes:   Apple Podcasts Spotify Soundcloud Pandora YouTube   This episode of The Model Health Show is brought to you by Four Sigmatic and Essentia. Visit foursigmatic.com/model to get an exclusive discount on mushroom and adaptogen-packed blends to improve your life. Essentia makes the best performance certified non-toxic mattresses. Get a discount on any organic mattress when you use my link, myessentia.com/model.  

Description: Co-hosts Ryan Piansky, a graduate student and patient advocate living with eosinophilic esophagitis (EoE) and eosinophilic asthma, and Holly Knotowicz, a speech-language pathologist living with EoE who serves on APFED's Health Sciences Advisory Council, interview Dr. Melanie Ruffner, an Attending Physician with the Division of Allergy and Immunology and the Center for Pediatric Eosinophilic Disorders at Children's Hospital of Philadelphia. Dr. Ruffner describes her work in clinic and the paper she co-authored about pediatric and adult eosinophilic esophagitis (EoE). She covers the questions they considered in the paper and the conclusions they reached. Disclaimer: The information provided in this podcast is designed to support, not replace the relationship that exists between listeners and their healthcare providers. Opinions, information, and recommendations shared in this podcast are not a substitute for medical advice. Decisions related to medical care should be made with your healthcare provider. Opinions and views of guests and co-hosts are their own.   Key Takeaways: [:49] Co-host Ryan Piansky introduces the episode, brought to you thanks to the support of Education Partners Bristol Myers Squibb, GSK, Sanofi, Regeneron, and Takeda. Ryan introduces co-host Holly Knotowicz.   [1:17] Holly introduces today's topic, pediatric and adult eosinophilic esophagitis (EoE), and introduces today's guest, Dr. Melanie Ruffner.   [1:23] Dr. Melanie Ruffner is an attending physician with the Division of Allergy and Immunology in the Center for Pediatric Eosinophilic Disorders at Children's Hospital of Philadelphia. Holly welcomes Dr. Ruffner to Real Talk.   [1:50] As an attending physician in the Center for Pediatric Eosinophilic Disorders at Children's Hospital of Philadelphia, Dr. Ruffner sees patients who have eosinophilic esophagitis and other eosinophilic disorders, including eosinophilic GI tract disorders.   [2:09] Dr. Ruffner also leads a research group that studies how the immune system causes inflammation in response to certain foods, leading to EoE.   [2:20] Inflammation in the esophagus is tied to other diseases like epithelial barrier dysfunction and fibrosis.   [2:28] Our bodies use many different proteins that allow cells to communicate with one another. One type of signaling protein that causes inflammation is called cytokines.   [2:41] Dr. Ruffner's group is interested in how these signaling proteins called cytokines interact with epithelial cells and how that impacts the oral function of the esophagus in patients with EoE.   [3:02] In training, Dr. Ruffner became interested in eosinophilic esophagitis and other non-IgE-mediated food allergies because we don't have a lot of clear treatments or clear mechanisms that cause them.   [3:21] Dr. Ruffner felt there was a lot of work to be done in that area. It was rewarding to be in clinical encounters with those patients. Often, patients had spent a long time trying to find out what was happening and to find a treatment plan that worked for them.   [4:31] Dr. Ruffner's group sees some patients who have eosinophilic gastroenteritis and patients who are referred for hypereosinophilia with impacts of inflammation in other organ systems.   [5:06] Dr. Ruffner co-authored a paper about pediatric and adult EoE published in the Journal of Allergy and Clinical Immunology. It explored if EoE in pediatric patients and adult patients is a spectrum or distinct diseases.   [5:29] EoE is a chronic allergic condition that affects the esophagus. The esophagus carries food from the mouth to the stomach. In people with EoE, the immune system overreacts to foods and causes inflammation in the esophagus.   [5:47] Eosinophils are a type of white blood cell. Eosinophils infiltrate the tissue in the esophagus of people with EoE. Doctors look for eosinophils in the tissue of the esophagus as a sign that inflammation in the esophagus is EoE.   [6:04] The symptoms of EoE can vary in children and adults. That was one of the things the doctors were interested in when they were thinking about this paper. There are no blood or allergy tests that make it easy to diagnose EoE, which requires an endoscopy.   [6:31] An endoscopy is performed by a gastroenterologist. The gastroenterologists look at the appearance of the esophagus and take biopsies.   [6:49] A pathologist counts the eosinophils in the tissue to determine if there are eosinophils present. If there are more than 15 eosinophils in the high-powered field of the microscope and symptoms and clinical conditions are present, EoE is diagnosed.   [7:25] One of the variables Dr. Ruffner considers is that symptoms can be different in children versus adults. In older adolescents and adults, the classic symptom is difficulty swallowing or dysphagia. That is often caused by fibrosis in the esophagus.   [7:54] In younger children this is often not how EoE presents. They may vomit or refuse food. They may experience more weight loss. Symptoms vary over the lifespan. Pediatric EoE symptoms of nausea and abdominal pain can also show up in adults.   [9:54] Atopy refers to allergic conditions. In the paper, a history of atopy means a history of allergic conditions, like atopic dermatitis, IgE-mediated food allergy, allergic rhinitis, or asthma.   [10:37] These disorders tend to cluster together, over time, because they share many common genetic risks. They cluster in families because some of the genetic risks are the same. Not every family member will have the same atopic or allergic conditions.   [11:07] In families, perhaps one person will have atopic dermatitis and allergic rhinitis while another will have atopic dermatitis, allergic rhinitis, asthma, and EoE. They may have inherited different genetics or had different environmental exposures.   [11:50] Ryan says that describes his family. They each have different atopic conditions. Ryan got them all! Dr. Ruffner says it describes her family, as well.   [12:26] Dr. Ruffner says it's understandable for families to stress about atopic conditions. Unfortunately, right now, there's no way to predict who will develop which atopic conditions. It's on the minds of the medical and research communities.   [13:10] IgE is an antibody that binds to food allergens and mediates anaphylaxis, usually within 30 minutes, with hives, vomiting, and difficulty breathing. Not everyone with a diagnosed food allergy will be given an epinephrine auto-injector.   [13:44] IgE-mediated food allergies are influenced by type 2 cytokines. Cytokines are immune system signaling proteins that have been labeled as groups. The group that is involved in allergy most heavily is under the label type 2.   [14:15] These type 2 cytokines are responsible for influencing B cells to make IgE. In the tissue in EoE, we find that there is a large amount of these type 2 cytokines present.   [14:37] This is quite relevant because dupilumab, the monoclonal antibody that has been approved to treat EoE, targets type 2 inflammation by blocking type 2 cytokines.   [16:04] Dr. Ruffner says one of the biggest challenges in the field of EoE is we don't have a way to stratify who should get which treatment for EoE. Patients have to choose between diet and pharmacologic therapy.   [16:48] We don't know enough about the inflammatory profiles to give any patient the specific guided information that one therapy would be better than another.   [17:11] Pediatric and adult patients are given the same treatment options. Some dosing, such as proton pump inhibitors and dupilumab, is weight-based so different doses are needed.   [17:36] Over time, people's needs change. From early school age to when people leave home, they may have very different needs. They may do well on diet therapy when their diet is controlled by parents, but, on their own, that may not be the best option for them.   [18:20] Therapy may change over time to support each patient's individual goals. It can be challenging because therapies are imperfect. Each therapy has a percentage probability of success. Not every therapy is guaranteed to work for every individual.   [19:01] There is some flexibility and possibility of switching between therapies to support people. Ryan shares one of his experiences in changing treatments.   [20:03] Some patients are stable on a therapy for a time but then see symptoms creep back up. Dr. Ruffner strongly suggests they talk to their care team for an endoscopy and biopsy to see if they need to switch therapy and if their diet has changed.   [21:31] In young children, Dr. Ruffner sees a much higher incidence of feeding refusal. The child may have a preferred food or a preferred texture like puree, long past when that would be appropriate for the age.   [22:41] It can be very difficult to move past this learned behavior even if remission is achieved through therapy. The child may need feeding therapy to help with that. [22:59] Feeding behaviors in older individuals may be much more subtle. Talk about them with your care team. Needing water to eat, cutting food very small, and fearing to eat around people are common eating behaviors to discuss in older patients.   [23:53] These eating behaviors affect people's well-being deeply because they affect how social they feel when they are around people. Ideally, you want to be around people and share in social times.   [24:16] Holly has used these eating behaviors herself and notices them in other people. When adults come to her for therapy, she asks how many times they refill their water when they eat, and if food ever gets stuck. They are surprised that those are symptoms.   [26:01] Dr. Ruffner says it's important to recognize the difference in symptoms in diagnosing EoE. The main risk factor of EoE is fibrosis, over time. The thought is that early in EoE there is an inflammatory phenotype, but later, there is a fibrotic phenotype.   [26:51] The phenotype refers to the presentation or characteristic of disease. What is the appearance at endoscopy? What do we see in the biopsied tissue? Is there fibrosis or not?   [27:15] This is the crux of the paper: Is this on a spectrum, that the inflammation is driving the fibrosis, or are these two different things altogether? There is some evidence to suggest that the inflammation contributes to this fibrosis over time.   [27:40] One thing that is missing is following a group of patients from the start and having that evidence. There is mechanistic evidence from studies to show that inflammation can contribute to fibrosis. That was one of the discussions in the paper.   [28:29] In endoscopies, something that can be seen with fibrosis or fibrostenotic features is more of an appearance of rings and narrowing of the esophagus. A proportion of patients with strictures or narrowing need to have them dilated.   [29:11] For patients who have dilation, it can help with symptoms significantly. When pathologists look at the tissue with fibrosis, they can see changes in the protein structure. There is more collagen and other changes in the tissue, causing fibrosis.   [30:03] Some patients use adaptive eating behaviors to adapt to significant changes in their esophagus and go for many years without being diagnosed until they present with an impaction when food becomes stuck in their esophagus.   [30:46] This makes EoE a challenging disorder for many because it can be very difficult to diagnose. The journey to a diagnosis is very individual. As a group, adults are much more likely to have fibrosis, leading to dysphagia, strictures, or impaction.   [31:25] Statistically, across all patients, you see fibrosis more in adults than in children.   [32:42] In the paper, Th1 cells are mentioned. Th1 is an immune system term referring to a cell that produces interferon-gamma. Studies show there may be differences in interferon signaling in different age groups but it needs to be studied further.   [33:57] Dr. Ruffner's team had looked at a small group and saw that interferon signaling seemed to be relatively similar between children and adults. Both CD4 and CD8 T cells (types of immune system cells) are potentially producing interferon in the esophagus.   [34:32] More study needs to be done around those immune system cells and their potential significance in EoE, if any.   [35:33] The paper suggests that EoE in children and adults is essentially a spectrum of the same disorder rather than distinct diseases.   [35:42] Aspects of immunology, responses to different treatments across children and adults, the similar responses to diet and different medications, and over time in the same individuals, indicate these are changes and complications over time.   [36:41] Dr. Ruffner suggests that medical researchers need to understand which patients are at the highest risk of complications and work to identify the best treatments to prevent those.   [37:14] Dr. Ruffner is thinking about the response to proton pump inhibitor therapy. One of the things she is looking at is whether or not proton pump inhibitors affect how eosinophils migrate into the tissue.   [37:33] They are finding that it seems that PPIs can decrease the degree of migration of eosinophils into the tissue. They are very interested in looking at that. Ryan says when Dr. Ruffner gets that paper published, she'll have to come back on the show!   [38:06] Ryan thanks Dr. Ruffner. For our listeners who would like to learn more about eosinophilic disorders, including EoE, please visit APFED.org and check out the links in the show notes.   [38:15] If you're looking to find a specialist who treats eosinophilic disorders, we encourage you to use APFED's Specialist Finder at APFED.org/specialist.   [38:24] If you'd like to connect with others impacted by eosinophilic diseases, please join APFED's online community on the Inspire Network at APFED.org/connections.   [38:33] Ryan thanks Dr. Ruffner for participating in the podcast episode. Holly also thanks APFED's Education Partners Bristol Myers Squibb, GSK, Sanofi, Regeneron, and Takeda for supporting this episode.   Mentioned in This Episode: Dr. Melanie Ruffner, MD, PhD, Attending Physician with the Division of Allergy and Immunology and the Center for Pediatric Eosinophilic Disorders at Children's Hospital of Philadelphia “Pediatric and adult EoE: A spectrum or distinct diseases?” by Stanislaw J. Gabryszewski, Melanie A. Ruffner, and Jonathan M. Spergel   APFED on YouTube, Twitter, Facebook, Pinterest, Instagram Real Talk: Eosinophilic Diseases Podcast apfed.org/specialist apfed.org/connections   Education Partners: This episode of APFED's podcast is brought to you thanks to the support of Bristol Myers Squibb, GSK, Sanofi, Regeneron, and Takeda.   Tweetables:   “EoE is a chronic allergic condition that affects the esophagus. The esophagus carries food from the mouth to the stomach. In people with EoE, the immune system overreacts to food allergens and causes inflammation in the esophagus.” — Dr. Melanie Ruffner   “In EoE, there are no blood or allergy tests that make it easy to diagnose EoE without an endoscopy.” — Dr. Melanie Ruffner   “Is EoE on a spectrum, that the inflammation is driving the fibrosis, or are these two different things altogether? There is some evidence to suggest that the inflammation contributes to fibrosis over time.” — Dr. Melanie Ruffner   “When pathologists look at the tissue with fibrosis, they can see the changes in the protein structure.” — Dr. Melanie Ruffner   “There are some folks who have adapted their eating behavior quite significantly and may have quite a number of chronic changes in their esophagus that they have adapted around, and they go for many years without being diagnosed.” — Dr. Melanie Ruffner

This episode contains insights into a relatively new perspective on immune health that will really fascinate and engage you. JP and Dr Stewart discuss things we hear about in our profession on a daily basis – auto immune issues, allergies, food intolerance, symptoms that indicate deeper issues – and look into what actions are afoot in peoples immune systems that can lead to their problems. Are they dominant in a catabolic (TH1) pathway for example, and if so, where did it all start? It gets more interesting as they examine where initial ‘insults' to immune health begin (mental, emotional and physical), where they lead if unchecked and just as importantly, what we can do about it through accessible changes in lifestyle. You'll never look at stress, inflammation and the nervous system the same again! Dr Stewart Gillespie is a functional medicine practitioner with over 20 years of clinical experience. Trained as an osteopath in London and a chiropractor in New York, Stewart has worked closely with Dr Eric Berg for 4 years – dealing with hormones and weight loss, as well as interpreting blood work & functional lab testing. Stewart has also undertaken many training programs & mentorships, including learning from Charles Poliquin, Datis Kharrazian, Functional Medicine University & the Kalish Institute. Dr Stewart Gillespie is best-known for his expertise in the immune system & his quick, effective protocols based on the 7 different types of inflammation. He teaches this signature method to health professionals around the globe through live workshops and functional medicine mentorship programs. Website: https://functionalmedicineservices.com Instagram: https://www.instagram.com/functionalmedicineservices/ and IG Handle: @functionalmedicineservices & @drstewartgillespie Facebook: https://www.facebook.com/functionalmedicineservices How to learn more: Functional Medicine Foundations Course (7 hours): https://functionalmedicineservices.com/course/foundations/ Inflammation Mastery Mentorship (10 Weeks): https://functionalmedicineservices.com/inflammation-mastery/ Functional Medicine Mentorship (6 months): https://functionalmedicineservices.com/mentorship/

In this special episode of the RWS Clinician's Corner, we have the privilege of hosting Dr. Chris Turnpaugh, a renowned figure in the field of functional medicine and the medical director of Restorative Wellness Solutions. Dr. Turnpaugh delves into the critical relationship between toxin exposure and susceptibility to infectious diseases such as Lyme and Long Covid. He shares groundbreaking insights on how the accumulation of environmental toxins can shift immune responses, potentially increasing vulnerability to infections, as well as offering strategies to support detoxification, adjust immune system balance, and improve overall resilience. Whether you're a seasoned functional health practitioner or just delving into this field, the clinical pearls Dr. Turnpaugh shares in this episode provide a vital understanding of how to tackle complex health challenges in today's increasingly toxic world.   In this interview, we discuss:    - Increased susceptibility to chronic infections due to environmental toxins and the influence   of toxins on TH2 dominance in the immune system   - Testing options and how to address complex client cases   - Strategies for addressing toxic burden (e.g., detoxification, supplementation, etc.)   - Prevention and maintenance strategies The Clinician's Corner is brought to you by Restorative Wellness Solutions.  Follow us: https://www.instagram.com/restorativewellnesssolutions/   Connect with Dr. Chris Turnpaugh: Website: TurnpaughHWC.comFacebook: https://www.facebook.com/TurnpaughHWC/ Instagram: TurnpaughHealth   Timestamps:  00:00 "Linking Toxin Burden to Infections" 05:00 Chemicals Weaken Immune Response 09:06 Decreased Resilience to Modern Stressors 12:22 Chemical Exposure in Daily Life 14:14 Exploring Tailored Detox Strategies 16:55 Challenges in Treating Fragile Patients 21:44 Hormone Health: Reducing Toxic Burden 24:55 Chronic Illness Resolutions Compared 28:00 Root-Cause Health Training Program 29:16 "Symptom Differentiation in Clinical Process" 34:44 Digital PCR for Bartonella Testing 35:29 Understanding Post-Infection Symptoms 38:42 "Fish vs. Digital PCR Testing" 42:24 Balancing Tregs and Th1/Th2 46:59 Preventive Health: Balancing the Immune System 48:26 Essential Desert Island Supplement: NAC 54:16 Understanding Patient Conditions and Treatment Priorities 56:39 "Clinician's Corner Podcast Highlights"   Speaker bio: Dr. Chris Turnpaugh is a practitioner and CEO at Turnpaugh Health, a Functional Medicine wellness center, which he founded in 1999. The center, one of the largest in the country, has grown to over 20 healthcare providers and a team of more than 50 in five locations.  Turnpaugh Health provides in-depth holistic care focusing on functional medicine, investigating the mechanisms of dysfunction in patients. The clinic also provides integrative family medicine, lifestyle medicine, and many complementary wellness services.  Over his twenty years in practice, Dr. Turnpaugh has joined ILADS and is known as a thought leader in Lyme disease and associated co-infections. He also traveled to Lake Como to participate on the PANDAS International board. He has a deep interest and extensive knowledge in pediatric neurological disorders and methods of supporting these children holistically. Dr. Turnpaugh has lectured on a broad variety of health topics, both nationally and internationally.  His application of functional medicine as it relates to the neuro/endocrine/immune systems is a unique clinical approach to non-pharmacological treatments. He is well respected among his peers and patients as a provider and functional medicine instructor. He has treated thousands of patients in his practice and mentored hundreds of practitioners. His true passion is teaching functional medicine to other practitioners and helping patients to optimize their health. Keywords: Restorative Wellness Clinicians Corner, functional health professionals, functional medicine, toxin burden, infectious diseases, chronic infections, TH1 and TH2 immune system, Lyme disease, Long Covid, autoimmune conditions, root cause medicine, total tox burden, detox pathways, environmental toxins, mold exposure, Cryptolepis, immune system balance, TH2 dominance, glutathione, NAC supplementation, environmental toxicity, reducing toxic exposure, tick bite prevention, laboratory testing, immune dysregulation, chronic illness recovery, viral infections, vitamin D, quercetin, microbiome health, detoxification   Disclaimer: The views expressed in the RWS Clinician's Corner series are those of the individual speakers and interviewees, and do not necessarily reflect the views of Restorative Wellness Solutions, LLC. Restorative Wellness Solutions, LLC does not specifically endorse or approve of any of the information or opinions expressed in the RWS Clinician's Corner series. The information and opinions expressed in the RWS Clinician's Corner series are for educational purposes only and should not be construed as medical advice. If you have any medical concerns, please consult with a qualified healthcare professional. Restorative Wellness Solutions, LLC is not liable for any damages or injuries that may result from the use of the information or opinions expressed in the RWS Clinician's Corner series. By viewing or listening to this information, you agree to hold Restorative Wellness Solutions, LLC harmless from any and all claims, demands, and causes of action arising out of or in connection with your participation. Thank you for your understanding.  

In this podcast, I discuss many of the HY skin and soft tissue infections you need to know for your exam. Easy points if you devote time to learning them. Quick errata: for leprosy, the lepromatous form is a TH2 issue, the tuberculoid form is a TH1 issue. I mixed the numbers up in the … Continue reading DIP Ep 570: The Clutch Skin and Soft Tissue Infections Podcast (Step 1-3) + Minor Correction

Liz & Becca dive deep into the complexities of the immune system, breaking down the difference between TH1 and TH2 responses. Discover how an imbalanced immune system could be the root cause of everything from chronic fatigue and autoimmunity to recurring infections and inflammation. They explore the triggers, symptoms, and actionable strategies to restore balance, from fasting and peptides to functional testing. If you've ever wondered why your body feels stuck in a cycle of stress and symptoms, this episode will give you the tools and insights to finally move forward. ***

In this episode of Derms and Conditions, host James Q. Del Rosso, DO, welcomes Mona Shahriari, MD, associate director of clinical trials at Central CT Dermatology and assistant clinical professor at Yale University, to discuss the challenges of treating pregnant and breastfeeding patients, particularly those with atopic dermatitis (AD). The conversation addresses a crucial yet often unclear topic for dermatologists: balancing safety and efficacy when managing AD in patients during pregnancy and lactation. Dr Shahriari emphasizes the importance of addressing uncontrolled inflammation, which can have potential consequences for both the mother and baby, such as premature birth and maternal sleep disruption. She shares insights into the physiological changes during pregnancy, including the shift from a Th1 to a Th2 immune state, and how this can impact conditions like AD and psoriasis. The discussion highlights the limited data available for systemic treatments in this population, as pregnant women are excluded from clinical trials. Despite this, therapies like dupilumab and cyclosporine are discussed for their safety profiles, with dupilumab often considered when patients need effective control with minimal risk. Dr Shahriari also addresses strategies to involve partners in treatment decisions, ensuring patients feel supported and informed. Drs Del Rosso and Shahriari emphasize the importance of open communication with patients, managing risk tolerance, and understanding the nuances of systemic treatment in pregnancy and lactation. Dr Shahriari shares real-world cases, including the use of dupilumab in a pregnant patient with severe AD and counseling a patient with psoriasis who unintentionally administered a biologic injection during the first trimester. Tune in to the full episode for practical guidance on navigating these complex cases and balancing patient care with available evidence. This episode is a must-listen for dermatologists managing pregnant or breastfeeding patients with inflammatory skin conditions.  

Dr. Charlie and Nurse Lauren dive into listener questions on boosting white blood cell count, managing nerve pain, detoxing post-vaccine, and more. Learn practical tools, supplements, and lifestyle tips in this episode. What Can I Do to Increase White Blood Cell Count? Optimal Range: 5-8 Above 8? Indicates active infection. Below 5? Often points to chronic infection (viruses and mold are common culprits). Suggested Supplements: Immune RMOR – SHOP HERE Golden Thread Supreme – SHOP HERE Scutellaria Supreme – SHOP HERE VerVita InspiraCell – SHOP HERE SuperStratum Mold Cleaner – SHOP HERE (Use code REDPILL for 10% off) Astragalus Supreme – SHOP HERE Reishi Supreme – SHOP HERE Lifestyle Tip: Eat ginger to boost TH1 and white blood cell count. How to Manage Long-Term Nerve Pain from Shingles Find a Quantum Neurologist for nerve recovery. Check the Directory Here. Tools and Supplements: Red Light Therapy by Fringe – SHOP HERE Melia Supreme – SHOP HERE VerVita Klenz+ – SHOP HERE Woad Supreme – SHOP HERE Reishi Supreme – SHOP HERE Camu Supreme – SHOP HERE Nutrient Support: High doses of Folate, B12, Vitamin C, and Cod Liver Oil. Fullscript Recommendations: Biotics Research B12 2000 Biotics Research Lipoic Acid Cod Liver Oil 1025  Detox from the COVID Vaccine Key Supplements: BodyBio PC – SHOP HERE GlyphoX Supreme – SHOP HERE Cat's Claw Supreme – SHOP HERE Klenz+ – SHOP HERE Camu Supreme – SHOP HERE D Spike – SHOP HERE Resource: Shop Rooted Remedies Products Here. Use code:naturalnursemomma How to Manage High DHEA Recommended Supplements: Scutellaria Supreme –  VerVita Black Cumin – SHOP HERE VerVita RegenerZyme Heart – SHOP HERE Schisandra Supreme – SHOP HERE Lifestyle Tip: Use castor oil packs for hormonal balance. Shop Castor Oil Packs on Amazon. How to Handle Psoriasis Recommended Supplements and Tools: Golden Thread Supreme – SHOP HERE Melia Supreme – SHOP HERE Klenz+ – SHOP HERE Red Light Therapy- SHOP HERE Cir Q Tonic – SHOP HERE Quinton Isotonics – Fullscript Fish Oil - Fullscript Gastro Digest – SHOP HERE

Your immune system is so much more than just fighting off the occasional cold. It is deeply connected to EVERYTHING in your body and can be a primary root cause of many common (but not normal) health issues! From chronic fatigue, IBS, and painful periods to stubborn weight loss resistance, skin issues, and more the immune system plays a role! In this episode, we're diving deep into how your immune system works, what happens when TH1, TH2, and TH17 cells go into overdrive, and the signs that your immune system might be out of balance. If you're dealing with autoimmune conditions, chronic inflammation, or mysterious symptoms that just won't go away, this episode is for you. I'll be breaking down how to spot the signs, understand your body's signals, and most importantly, what you can do to support and rebalance your system based on your unique symptoms and health history. If you need help getting to the root cause of your health issues or symptoms click here to apply for coaching!

TWiP reviews a study showing that intestinal helminth infection impairs vaccine-induced T cell responses through an IL-10 pathway, which compromised protection against antigenically drifted SARS-CoV-2 variants. Hosts: Vincent Racaniello, Daniel Griffin and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Worms impair COVID vaccines (Sci Trans Med) Heligmosomoides image (Wiki Commons) Become a patron of TWiP  Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

BUFFALO, NY- August 16, 2024 – A new #review was #published as the #cover paper of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 15, entitled, “Types of cell death and their relations to host immunological pathways”. Various immune pathways in the host, such as TH1, TH2, TH3, TH9, TH17, TH22, TH1-like, and THαβ, have been identified. While TH2 and TH9 responses primarily target multicellular parasites, host immune pathways against viruses, intracellular microorganisms (like bacteria, protozoa, and fungi), and extracellular microorganisms utilize programmed cell death mechanisms to initiate immune responses and effectively eliminate pathogens. In their review, researchers Kuo-Cheng Lu, Kuo-Wang Tsai, Yu-Kuen Wang, and Wan-Chung Hu from Taipei Tzu Chi Hospital, Fu Jen Catholic University, Taoyuan Armed Forces General Hospital, Tri-Service General Hospital and Ming Chuan University, reviewed these cell death pathways associated with the host immunological pathways. "These relationships can help us understand the host defense mechanisms against invading pathogens and provide new insights for developing better therapeutic strategies against infections or autoimmune disorders.” DOI - https://doi.org/10.18632/aging.206035 Corresponding authors - Wan-Chung Hu - Wanchung.Hu09@tzuchi.com.tw Video short - https://www.youtube.com/watch?v=oPaevm0vpR8 Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206035 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, apoptosis, autophagy, ferroptosis, necroptosis, NETosis, pyroptosis About Aging-US The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population. The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.) Please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Die faszinierende Verbindung von Schulter und Leber (Podcastshort) --> Aus Folge 36: Podcast - Selbstheilung durch Gedanken Hier geht es zur ganzen Folge: https://open.spotify.com/episode/7q7xXRThHhRifHexUJPdsB?si=T-jUWf-cTkSiZUFDtRl83g Jeden Samstag um 12 Uhr gibt es wie gewohnt eine reguläre (lange) Folge in meinem Podcast: "Selbstheilung durch Gedanken" Die Leber wird von einer Leberkapsel (Faszie) umhüllt, die dem Zwerchfell von unten anliegt und mit diesem verbunden ist. Sowohl die Leberkapsel als auch das Zwerchfell selbst werden durch den N. Phrenicus nerval versorgt. Der N. Phrenicus entspringt den Halswirbeln C3 bis C5. Neben dem N. Phrenicus gibt es im Halsbereich zwei große Nervengeflechte: den Plexus Cervicalis (C1 bis C4) und den Plexus Brachialis (C5 bis Th1). Probleme mit der Leber können zu Irritationen des N. Phrenicus führen, was wiederum den Plexus Cervicalis und Plexus Brachialis beeinflussen kann. Diese Nervengeflechte versorgen die gesamte Schultermuskulatur motorisch. Dadurch können muskuläre Dysbalancen im Schulterbereich entstehen, die langfristig zu Schmerzen führen können. Emotionen spielen eine bedeutende Rolle in unserer körperlichen Gesundheit. Unangenehme Gefühle und Emotionen wie Wut können körperliche Symptome hervorrufen oder bestehende Beschwerden verschlimmern. Die Leber wird oft als „Sitz der negativen Emotionen“ angesehen, insbesondere in der traditionellen chinesischen Medizin (TCM), wo sie sehr eng mit der Emotion Wut in Verbindung gebracht wird. Allerdings können hier noch weitere Verbindungen zu Emotionen in Betracht gezogen werden. Und genau aus dieser Gefühlslage können sich Schulterschmerzen entwickeln. Denn nicht nur über das nervale System ist die Leber mit der Schulter in Verbindung, sondern auch über das psychosomatische System. D.h. Menschen, die innerlich eine große Last tragen, tragen diese in Form von negativen Gefühlen wie z. B. Kummer, Schuld, Traurigkeit, Eifersucht und Neid, die sich nicht selten in Aggression verwandelt. Diese innere Last kommt zu der äußeren Last hinzu und ist ein Spiegel der Verantwortung, die sich unbewusst auf die Schulter gezwungen wird. Jeden Samstag um 12 Uhr gibt es wie gewohnt eine reguläre (lange) Folge in meinem Podcast: "Selbstheilung durch Gedanken"

In today's episode, we explore the role of Thymosin Alpha 1 Peptide in modulating the immune system, specifically its effects on Th1 and Th2 responses. The episode further delves into the mechanisms by which Borrelia burgdorferi evades immune detection and offers strategies to enhance immune effectiveness against this stealthy pathogen. Additionally, we discuss the broader implications of immune modulation in chronic Lyme disease and mold exposures. Topics: Introduction Recap of the series on Lyme and mold Highlighting the key steps in the biotoxin illness resolution process Importance of working with a medical professional Key Steps in Biotoxin Illness Resolution Lowering inflammation Lipid replacement therapy (phospholipids) Use of antimicrobial and antiparasitic herbs for Lyme and coinfections Employing binders to eliminate toxins and reduce inflammation Checking for MARCoNS and utilizing treatments like silver spray or biofilm busters (e.g., xylitol) Detoxification post-MARCoNS clearance using agents like chlorella and glutathione Assessing and normalizing various health markers (e.g., ADH, osmolality, MMP9, C4a, C3a, TGF-beta, sex hormones) Additional Resources and Episodes Early stages of Lyme infection and Herxheimer reaction: Episode 116 Chronic inflammation and biotoxin management: Episode 117 Role of binders in interrupting enterohepatic circulation and toxin elimination Discussion on Biofilm Importance of addressing biofilm in antimicrobial therapies Potential supplements and strategies (e.g., garlic, oil of oregano, stevia) Overview of Lyme Disease Impact & Immune Function Chronic inflammation due to miscommunication between the innate and adaptive immune systems + dysregulated adaptive responses How borrelia evades the immune responses Immunomodulation in Lyme Disease Background on immune modulation Role of T cells in adaptive immune response Th1 and Th2 cell imbalance in chronic Lyme Strategies to support Th1 cells and decrease Th2 response Focus on Thymosin Alpha 1 Benefits of Thymosin Alpha 1 in modulating immune function Promoting Th1 response and managing Th2 dominance Effects on regulatory T cells (Tregs) and immune tolerance Conclusion Reminder to work with a Lyme literate or biotoxin illness literate medical professional Thanks for tuning in! Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more! Or visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠linktr.ee/synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

Allergy season is upon us, and many are relying on medications like Benadryl, NyQuil, and Dramamine, which have been linked to an increased risk of dementia with long-term use. In this informative episode, I share the comprehensive protocol that helped me and numerous patients overcome allergies once and for all. We'll dive deep into the underlying causes of allergies, exploring the intricate interplay between the immune system, environmental factors, and gut health. From reducing toxic burdens and balancing the Th1/Th2 immune response to healing the gut and restoring beneficial bacteria, this episode provides a holistic blueprint for resolving allergies at their root. Get ready to bid farewell to the misery of sneezing, congestion, and itchy eyes as we uncover the path to lasting relief without the side effects of conventional medications. Show Notes: Understanding Allergies: Causes, Symptoms, and Common Allergens Genetic and environmental factors contributing to allergies Type I hypersensitivity reaction and the role of IgE antibodies Common allergens: environmental, food, insect, drug, and contact allergens The Overflowing Cup: Why Allergies Worsen Over Time Toxic burdens: environmental toxins, home toxins, inflammatory foods The impact of stress on the immune system's capacity Conventional Allergy Treatments: Effectiveness and Side Effects Over-the-counter and prescription medications: antihistamines, decongestants, corticosteroids Potential side effects: drowsiness, dry mouth, cognitive impairment, dementia risk The Naturopathic Approach: Treating the Whole Person and Getting to the Root Reducing the toxic burden Balancing the Th1 and Th2 immune response Healing the Gut: A Four-Step Process Recommended Resources and Further Reading: https://ndnr.com/autoimmuneallergy-medicine/allergies-a-route-to-resolution/ === Thank you to our sponsors! AquaTru https://aquatru.com and use code DRG for 20% off all products. Nuzest https://nuzest-usa.com/drg and use code DRG for 20% off all products. === Be sure to like and subscribe to #HealThySelf Hosted by Doctor Christian Gonzalez N.D. Follow Doctor G on Instagram @doctor.gonzalez https://www.instagram.com/doctor.gonzalez/ Visit https://www.elm.health/ to work directly with Dr. G.

Whether you're a parent concerned about your child's allergies or an allergy sufferer seeking relief, this episode promises to broaden your understanding and bring hope about available treatments! Dr. Gina Dapul-Hidalgo is a board-certified pediatric and adult allergy and immunology specialist, and she explains what allergies really are: the immune system's overreactions to typically harmless substances in the environment. She and Dr. Amigues discuss the different types of allergies, how antibodies work, and the effect of environment on allergies. Dr. Dapul also dives into allergen immunotherapy (desensitization), one of the oldest and most helpful methods for treating allergies. You've probably heard of allergy shots; these can decrease the sensitivity to allergens, reduce the need for medication, and are the closest thing to a cure for allergies! We'll end on a discussion about TH1 and TH2 cells, and the benefits of exposing children to dirt and germs for a resilient immune system. Getting dirty in nature is good for us!

With several health-promoting factors, dark chocolate has numerous health benefits and is considered a functional food due to its anti-diabetic, anti-inflammatory, and antimicrobial properties.Despite that, dark chocolate is excluded from an autoimmune paleo (AIP) diet, and there are a few reasons people with thyroid and autoimmune thyroid conditions should be cautious about eating it.Today, I'm sharing what you need to know about the potential downside of dark chocolate, why you should be cautious, and why I continue to eat dark chocolate on a regular basis.In this episode, you'll learn:- How dark chocolate's phytic acid content can affect nutrient absorption- The effects of cacao's polyphenols on T2 and TH1 helper cell activity- The risk of heavy metal contamination in chocolate products- Whether you should be concerned about chocolate's oxalate content- Safer choices for dark chocolateAs always, I hope you find this episode valuable, and I look forward to catching you in the next episode!To learn more, visit the show notes at https://savemythyroid.com/podcast/can-dark-chocolate-be-safely-eaten-by-those-with-thyroid-conditions/. Do You Want Help Saving Your Thyroid? Access hundreds of free articles at www.NaturalEndocrineSolutions.com Visit Dr. Eric's YouTube channel at www.youtube.com/c/NaturalThyroidDoctor/ To work with Dr. Eric, visit https://savemythyroid.com/work-with-dr-eric/

In this episode, hosts Jordan Briggs and Marcus White are joined by the insightful Dr. Stewart Gillespie to unravel the mysteries of the immune system. Dr. Gillespie provides valuable insights into the innate and acquired immune systems, shedding light on crucial concepts such as Th1, Th2, Th9, and Th17. Explore the complexities of immunology as the conversation delves into practical tools and hacks to fortify your immunity in the face of modern health challenges. Dr. Gillespie shares actionable tips to empower your immune system and enhance overall well-being.

Who has ever felt travel hungover? Who fears travel because you might have a chronic illness flare or the unknown away from your healing home?  Look I get it, travel used to make me so dang anxious. It took a whole entire routine just to feel good at home, throwing travel in as a variable to the mix was just plain hard! Until I learned the secret tricks and tools that helped me heal my 8 different autoimmune diseases into remission while I traveled, and see the world all at the same time! Nowadays, I feel like my superhuman self and enjoy traveling at least 1-2 times a month. I want you to remember that your body is not broken, if you have AUTOIMMUNE DISEASE you can 100% heal.  Travel may just be one of the necessary ingredients with a few necessary directions. So buckle up, press play, and let's go full speed ahead into this episode!   Show notes: WATCH this episode here: https://www.inspirehealthbyjen.com/heal-your-autoimmune-symptoms-signup   AUTOIMMUNE HEALING RESEARCH GROUP WAITLIST: https://www.inspirehealthbyjen.com/heal-your-autoimmune-symptoms-signup   WORK WITH JEN 1-1 https://www.inspirehealthbyjen.com/discovery-call HEALING RETREAT: https://www.inspirehealthbyjen.com/retreats IN-HOME INFRARED SAUNA: https://www.inspirehealthbyjen.com/infrared-therapy CONNECT WITH JEN: https://www.inspirehealthbyjen.com/work-with-jen  INSPIRE HEALTH FACEBOOK GROUP: https://www.facebook.com/groups/inspirehealthhealing/ Have a question? Send a request and we may feature it on a future episode!: https://forms.gle/bbpYJKTPhmsezYs3A Study mentioned:Assaf, A. M., Al-Abbassi, R., & Al-Binni, M. (2017). Academic stress-induced changes in Th1- and Th2-cytokine response. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 25(8), 1237–1247. https://doi.org/10.1016/j.jsps.2017.09.009   Free Guide(s): One Day Detox Recipes: https://www.inspirehealthbyjen.com/subscribe-to-pdf Full Moon Meditation: http://www.inspirehealthbyjen.com/subscribe-for-full-moon-meditation Energy Healing Audio: https://www.inspirehealthbyjen.com/energy-healing-audio-download  Find Out More: www.inspirehealthbyjen.com  Blog: www.middaypigeon.com   If you have questions or would like me to help you get started… Let's get in touch and begin your true path of healing today. Your body and your mind will eternally thank you!

This amazing study demonstrates the influence of plant-based (high-fiber) and/or fermented food diets on our immune system. Researchers found that fermented foods like yogurt, kimchi, and kombucha caused a reduction of 19 cytokines including IL-6, IL-12b, and IL-10. This reduction may potentially lead to reduction in chronic inflammation. Let's review this study. DrBeen: Medical Education Online https://www.drbeen.com/ FLCCC | Front Line COVID-19 Critical Care Alliance https://covid19criticalcare.com/ References (August 18, 2023) Gut Microbiota-Targeted Diets Modulate Human Immune Status - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020749/ Figure - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020749/figure/F6/ Interleukin-6 as a Multifunctional Regulator: Inflammation, Immune Response, and Fibrosis - Ernest Choy, Stefan Rose-John, 2017 https://journals.sagepub.com/doi/10.5301/jsrd.5000265#:~:text=IL%2D6%20is%20produced%20by,cells%2C%20fibroblasts%2C%20and%20hepatocytes . Role of Interleukin 10 Transcriptional Regulation in Inflammation and Autoimmune Disease - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410706/#:~:text=In%20vivo%2C%20major%20sources%20of,granulocytes%20like%20neutrophils%20and%20eosinophils . Regulation of IL-10 and IL-12 production and function in macrophages and dendritic cells - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754024/#:~:text=Interleukin%2D12%20signaling,dendritic%20cells%20(DCs)%202 . Interleukin-10 production by effector T cells: Th1 cells show self control - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118719/ Disclaimer: This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.

Please Follow us and hit the bell to be notified when new episodes drop. Don't forget to Rate this episode and leave a comment. Rate and review your favorite episodes to let me know the things you like so I can keep delivering great content that brings value to your life and health. Check out my online store for self-learning/DIY programs for thyroid, gut health and detox.  You can use this form to reach out and request an Initial Consultation! Visit my LabShop store to self-order the same tests I use with my one-on-one coaching clients.  https://www.drnoseworthy.com/site/contact Follow us on social media Facebook Instagram You can also listen on Apple and Spotify - and all other major podcast platforms.    https://www.instagram.com/drnoseworthyhttps://www.facebook.com/becomeautonomoushttps://www.tiktok.com/@drsnoseworthy

In pursuit of mechanisms and evidence-based approaches, gut health has been revealed as a critical cornerstone of neurological health. In this episode, we're going into detail on what the gut layers are. I hope this video will help someone else who's trying to understand how the gut works for purposes of biohacking with functional medicine, nutrition, supplements, etc. For any intervention, is there evidence of a relationship, and is there data that it worked in other humans? We talk about: what the gut mucus is made out of elements of the gut barrier - the many ways the body keeps microbes and partially digested food away kinds of intestinal epithelial cells (Goblet cells, Paneth cells, M cells, etc.) and their functions types of gut associated lymphoid tissue (GALT) and their distinctions - lamina propria, Peyer's patches, lymph nodes the enteric nervous system and enteroendocrine cells different types of CD4+ T cells: Th1, Th2, Th17, and Treg, what they respond to, and their major outputs the mechanism of nutrient absorption the mechanism of leaky gut (paracellular transport through tight junctions) Here's the video: https://youtu.be/sIn_VxH6zDA Transcript of the video, for those who are pressed for time: https://www.brainforest.org/post/leaky-gut-anatomy I hope this helps someone understand their gut a little better on the path to health. Stay tuned for our next podcast on the relationship between leaky gut and aging. Share this resource with others who are studying gut anatomy on the path to health!

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.05.03.539317v1?rss=1 Authors: Kirkland, J. M., Patel, I., Ardeshna, M. S., Kopec, A. M. Abstract: Strong social support promotes a variety of positive health outcomes in humans and rodent models, while social isolation in rodents shortens lifespan, perceived social isolation (i.e. loneliness) can increase mortality by up to 50% in humans. How social relationships lead to these drastic health effects is unclear, but may involve modulation of the peripheral immune system. The reward circuitry of the brain and social behaviors undergo a critical period of development during adolescence. We published that microglia-mediated synaptic pruning occurs in the nucleus accumbens (NAc) reward region during adolescence to mediate social development in male and female rats. We hypothesized that if reward circuitry activity and social relationships directly impact the peripheral immune system, then natural developmental changes in the reward circuitry and social behaviors during adolescence should also directly impact the peripheral immune system. To test this, we inhibited microglial pruning in the NAc during adolescence, and then collected spleen tissue for mass spectrometry proteomic analysis and ELISA validation. We found that the global proteomic consequences of inhibiting microglial pruning in the NAc were similar between the sexes, but target-specific examination suggests that NAc pruning impacts Th1 cell-related immune markers in the spleen in males, but not females, and broad neurochemical systems in the spleen in females, but not males. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.26.538419v1?rss=1 Authors: Willet, A. H., Ren, L., Chen, J.-S., Gould, K. Abstract: Myosin-1s are monomeric actin-based motors that function at membranes. Myo1 is the single myosin-1 isoform in Schizosaccharomyces pombe that works redundantly with Wsp1-Vrp1 to activate the Arp2/3 complex for endocytosis. Here, we identified Ank1 as an uncharacterized cytoplasmic Myo1 binding partner. We found that in ank1{Delta} cells, Myo1 dramatically redistributed from endocytic patches to decorate the entire plasma membrane and endocytosis was defective. Biochemical analysis and structural predictions suggested that the Ank1 ankyrin repeats bind the Myo1 lever arm and the Ank1 acidic tail binds the Myo1 TH1 domain to prevent TH1-dependent Myo1 membrane binding. Indeed, Ank1 over-expression precluded Myo1 membrane localization and recombinant Ank1 blocked purified Myo1 liposome binding in vitro. Based on biochemical and cell biology analyses, we propose budding yeast Ank1 and human OSTF1 are functional Ank1 orthologs and that cytoplasmic sequestration by small ankyrin repeat proteins is a conserved mechanism regulating myosin-1s in endocytosis. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

It's hard to slow down when you're dopamine-dominant. Being highly motivated, fast-paced, and competitive has many benefits, but how can you slow down when it starts negatively impacting your health? Kris Gethin is on the podcast today to answer that, and much more! In this episode, Kris and Joe discuss their thoughts on stem cell therapy, how to choose what supplements to add and remove for optimal fitness, and how Kris uses biohacking to balance his training with his focus on living a long and healthy life. Kris also gives us an inside look at his daily routine and what he focuses on to optimize his diet and nutrition, which has resulted in him achieving a glycan age of 26 at the current chronological age of 48! Kris Gethin is the co-owner of KAGED supplements, co-owner of the Kris Gethin Gyms, owner of Kris Gethin coaching and a hybrid athlete. He is the former editor in chief of bbcom, former editor at large of FLEX and came 2nd in Natural World bodybuilding championships in 2006. - Find Kris Gethin on Instagram @krisgethin - Check out SelfDecode - Join Joe's online community - Follow Joe on Instagram & TikTok Timestamps: (0:00) - Introduction (2:56) - Kris' Daily Routine (10:42) - How Kris chooses his supplements (15:24) - HRV and training (21:18) - The neurochemistry behind overtraining and mood (26:13) - Kris labs and supplements (31:34) - Stem cells (33:50) - Longevity and bodybuilding (42:36) - How to improve glycan age (45:43) - Th1 vs Th2 and megadosing supplements

During this edition of the Thrivality:OutLoud Podcast, Steven Wright is back on the show to discuss his new creation - HoloImmune - which uses a new class of ingredients called ParaProbiotics - or heat treated young probiotics - to rebalance the two branches of your immune system, the Innate and Adaptive or TH1 and TH2. These branches modulate each other but can become imbalanced through stress or illness resulting in a host of problems from respiratory, skin, gut, or overall immune imbalances.And while HoloImmune uses something sounding like a ProBiotic - aka ParaProbiotics - this product is NOT intended for traditional gut flora repopulation; rather, HoloImmue re-estabishes proper cell to cell communication in the gut. Think of Vitamin C, Zinc, Quercertin, NAC as ingredients the immune system uses to do its job. And HoloImmune as the intelligence or “flight plans” to get the immune system rebalanced and “flying” in the right direction.Why you should listen: podcast topics & outline1. Why Steven and his team created the new HoloImmune cell signaling product that reboots the immune systems flight plans2. What are the two (2) branches of the immune system, Innate and Adaptive, where they are located and how they actually work3. The five (5) different ways the immune system can become dis regulated 4. How HoloImmune is different than traditional Immune System ingredients such as Vitamin C, Zinc, Quercertin, etc.5. How HoloImmune supports the Upper Respiratory System, Skin Health, and even those dealing with more complex health issues like Lyme or Mold6. HoloImmune's unique ParaProbiotic ingredients that don't act like a traditional probiotic, but rather intelligently rebalance and modulate the immune system7. Who HoloImmune is for and how much to takeSponsors and Linksa) Discount link for HoloImmune or use the discount code Thrive15 for $15 your first order @ www.HealthGut.com. Offer expires 10/31/2022b) for more information about me, journey, and offerings: http://www.thrivality.com

This episode of the podcast may be one of my all-time favorites. Dr. Vojdani is one of the leaders in the science and study of the immune system and autoimmunity. If you have hypothyroidism, Hashimoto's thyroiditis, another autoimmune condition, or food intolerances you are going to want to listen to this podcast. (Maybe multiple times.) In this episode we discuss: The basics of the immune system Th1 vs TH2 The role of the immune system in thyroiditis and why thyroid antibodies may not be the bad boys we thought they were. What causes immune activation and autoimmunity Loss of tolerance Food intolerance testing And so much more... This episode is packed with awesome information from one of the leaders in the industry. Aristo Vojdani obtained his MSc and PhD in microbiology and clinical immunology from Bar-Ilan University, Israel, with postdoctoral studies in comparative immunology at UCLA and tumor immunology at Charles Drew/UCLA School of Medicine and Science. He is a Clinical Professor at Loma Linda University in California, and an Adjunct Professor at the Lincoln College of Professional, Graduate and Continuing Education at the National University of Health Sciences.   Dr. Vojdani's ongoing research focuses on the role of environmental triggers in complex diseases, and he has developed more than 300 antibody assays for the detection of autoimmune disorders and other diseases. He has 17 US patents, over 200 articles, and two books, “Neuroimmunity and the Brain- Gut Connection” and “Food-Associated Autoimmunities: When Food Breaks Your Immune System,” to his name. He is the CEO of Immunosciences Lab in Los Angeles, California; the Chief Scientific Advisor for Cyrex Labs in Phoenix, Arizona; and, sits on the editorial board of five scientific journals. His many awards include the Herbert J. Rinkel Award (American Academy of Environmental Medicine), the Linus Pauling, PhD Award (American College for Advancement in Medicine), and the Personalized Lifestyle Medicine Institute Lifetime Achievement Award. Presently, Dr Vojdani is an Adjunct Associate Professor in the Department of Preventive Medicine at Loma Linda University in California, and an Adjunct Professor at the Lincoln College of Professional, graduate and continuing education at the National University of Health Sciences. He lectures at scientific and medical conferences around the world, spreading his knowledge and thereby improving the lives of patients once thought lost.

Guar Gum may be a potent Immune regulator Diets high in guar gum, a common food additive and dietary fibre, limited inflammation and delayed the onset of multiple sclerosis (MS) symptoms in mice, according to new research by members of the University of British Columbia (UBC) Microbiology and Immunology department. #guargum #ms # neuroinflammation Fettig NM, Robinson HG, Allanach JR, Davis KM, Simister RL, Wang EJ, Sharon AJ, Ye J, Popple SJ, Seo JH, Gibson DL, Crowe SA, Horwitz MS, Osborne LC. Inhibition of Th1 activation and differentiation by dietary guar gum ameliorates experimental autoimmune encephalomyelitis. Cell Rep. 2022 Sep 13;40(11):111328. doi: 10.1016/j.celrep.2022.111328. PMID: 36103823. Guar gum, fiber, fibre, autoimmune, neuroinflammation, th1, autoimmune encephalomyelitis, dietary fiber, microbiota, experimental autoimmune encephalomyelitis, EAE, multiple sclerosis, MS, CD4+ T cells --- Support this podcast: https://anchor.fm/ralph-turchiano/support

Guar Gum may be a potent Immune regulator Diets high in guar gum, a common food additive and dietary fibre, limited inflammation and delayed the onset of multiple sclerosis (MS) symptoms in mice, according to new research by members of the University of British Columbia (UBC) Microbiology and Immunology department. #guargum #ms # neuroinflammation Fettig NM, Robinson HG, Allanach JR, Davis KM, Simister RL, Wang EJ, Sharon AJ, Ye J, Popple SJ, Seo JH, Gibson DL, Crowe SA, Horwitz MS, Osborne LC. Inhibition of Th1 activation and differentiation by dietary guar gum ameliorates experimental autoimmune encephalomyelitis. Cell Rep. 2022 Sep 13;40(11):111328. doi: 10.1016/j.celrep.2022.111328. PMID: 36103823. Guar gum, fiber, fibre, autoimmune, neuroinflammation, th1, autoimmune encephalomyelitis, dietary fiber, microbiota, experimental autoimmune encephalomyelitis, EAE, multiple sclerosis, MS, CD4+ T cells --- Support this podcast: https://anchor.fm/ralph-turchiano/support

Microbigals are finishing up our series of the microbiome by bringing you a gut microbiome DaBOM. Tess, Julie, and Jon bring you articles on how the gut microbiome affect the bodies response to cancerous cells, how certain diet and feeding patterns affect the gut microbiome composition, and how administering a bacteria in mice positively affects obesity and type II diabetes. They also bring some industry news including self replicating ribosomes and a microbiome product filing for licensing. check out the links below. Articles and links Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota Diet and feeding pattern modulate diurnal dynamics of the ileal microbiome and transcriptome The microbiome restrains melanoma bone growth by promoting intestinal NK and Th1 cell homing to bone SERES THERAPEUTICS ANNOUNCES COMPLETION OF ROLLING BLA SUBMISSION TO FDA FOR INVESTIGATIONAL MICROBIOME THERAPEUTIC SER-109 FOR RECURRENT C. DIFFICILE INFECTION Self-replicating protein factories are a step towards artificial life   Thanks to our sponsor Zymo Research. you can find out more about the company and their products here.  Visit our website at microbigals.com where we are updating with new content, including blog posts, regularly. you can also find us on twitter @MicrobiGals. Also, if you would like to donate to our show, we have started a kofi page. you can donate on our website or visit https://ko-fi.com/microbigals.  

Ok so let's talk about gut health. Gut health and detox are pretty much the two most important topics, and toxins affect gut health....but good gut health is necessary for proper detoxification.....I think gut health wins. At least for this next podcast series :) Gut health is foundational to health, inflammation, and aging. It's so crucial, but so few people seem to have it mastered IF they are still experiencing symptoms, and I mean ANY symptoms - joint pain, fatigue, anxiety, depression, bipolar, metabolic, certainly autoimmune flares, not just digestive symptoms. I'm going to go deeper into some specific topics in the next few episodes, but this one is an overview, and I made a list of the 10 most important things for gut health. The first 3 are symptoms, the next 4 are mechanisms, and the last 3 are infections, and understanding these 10 things will give you a pretty good grasp on understanding gut health and digestion overall!Diarrhea - I talk about IBS, IBD, low microbiome and good bacteria/probiotics, glutamine, mast cells, and hydrogen SIBO....Constipation - I talk dysbiosis/methane, and a LOT about vagal motor outflow and vagus nerve activity that controls motility as well as HCL, bile, enzymes....Bloating - When I hear bloating I think small intestine and fermentation. Dysbiosis is often at the root, which includes proper digestion (HCL and bile), and I touch on SIBO/SIFO, avoiding FODMAPs foods....Digestion - This is critical!! Chewing your food, being in parasympathetic mode, then proper stomach acid - it can be too high (mast cells) or too low (more common), pancreatic digestive enzymes, bile from the gallbladder (steatocrit), and of course VAGUS BABY!Dysbiosis - The 10 lbs of bacteria in your gut can become imbalanced. Low good bacteria, general microbiome imbalances…..and LPS!!!!!Leaky Gut - Everyone can have some intestinal permeability, is yours pathological, and if so what kind is it - paracellular or transcellular? Food Sensitivities - IgG testing, and how food sensitivities can drive autoimmune reactivity, general inflammatory tone, and initiate T cell mediated tissue damageSIBO - Bloating! Fermentation of fibers, starches, sugars, FODMAPs ...why you need HCL, bile, vagus outflow……Why I think SIBO testing is dumb….Candida - OMG….the single biggest thing I see. Antibiotics, sugar, stress, birth control, mold exposure, can drive a Th17 inflammatory response (autoimmune), can also drive Th2 (and both will decrease Th1)......and why I love urinary organic acids testing for fungal issues.Parasites - this I am going to do a whole episode on because it's crazy, it's quite frankly pretty controversial in the autoimmune world, is it better to have or to not have them??? The answer is IT DEPENDS. But I do talk about someone who was diagnosed with Ulcerative Colitis and it actually seemed to be a parasitic infection, pretty interesting story :)Share this with someone, subscribe, leave a rating and review, and follow me elsewhere!

A stuffy nose (allergic rhinitis) is one of the most common symptoms of allergies, aka hay fever.Millions suffer seasonally, or just randomly, unable to fully appreciate blooming flowers, grassy meadows, furry four-legged pet friends, or other beauties in the environment.I, Dr. Ben, know this quite well first hand, as allergies and asthma kept me from feeling my best during soccer and baseball seasons as a kiddo. The prescription antihistamines and bronchodilating inhalers hardly worked to manage my chronic allergies... but then, everything changed when nature helped to put my immune system into balance. In today's Medicinal Monday episode we cover everything from managing allergy symptoms naturally, the power of nasal diaphragmatic breathing to help the body function in its best form, as well as the intricacies of immune balancing (Th1 and Th2).As always, you can join us live each Monday at 12 PT / 3 ET on the Alter Health YouTube Channel! https://www.youtube.com/alterhealthSome highlights from today's episode on Nose/Sinuses...The nose and sinuses filter and humidify air, providing first line of defense against invading pathogens and toxinsChronic congestion from allergies increases risk for upper respiratory infection including sinus infection and ear infectionAllergy symptoms can be immediately relieved from steam inhalation or alternating compress, as well as some herbs and supplements (nettels, butterbur, NAC, etc)The power of nose breathing to both prevent and reverse chronic congestion (and balance blood pressure, nervous system, oral microbiome, and more)How being too clean/sterile can chronically imbalance the immune system and exacerbate allergies (and other conditions related to Th2 dominance)Links to some more good stuff-  Join Alter Health on Locals: https://alterhealth.locals.com/- Cleanse with Us during the next Alter Health Cleanse: https://www.alter.health/cleanse- Work with us in the Thrive on Plants program: https://www.alter.health/thrive-on-plants- ATTN Health Practitioners! Learn more and apply to the Plant Based Mind Body Practitioner Program: https://www.alter.health/pbmb-practitionerPeace and Love.

Between 10-30% of the global population experiences allergic rhinitis, otherwise known as "hay fever," which is the most common presentation of environmental allergies.Honestly, I thought allergies were even more prevalent than this. The wide range is likely due to the fact that allergies tend to come and go, which can make them even more difficult to understand and get a handle on.Nevertheless, prescription and over-the-counter allergy medications, such as anti-histamines, are some of the most common pills to be swallowed in our world today. Even with such meds, it can be difficult to manage these symptoms... until now!No, no, no... there aren't any quick fixes to allergies. In fact, reversing allergies is a prime example of playing the long game to allow and encourage the immune system to find its innate balance.In a nutshell, the "allergens" that trigger an immune response aren't bad and we shouldn't have to fear or avoid them. The goal is to retrain and nourish the immune system to offer more resilience. We cover lots of science and strategies for managing and reversing allergy symptoms in today's episode.If you'd like to join these conversations live, be sure to Subscribe to the Alter Health YouTube Channel! https://www.youtube.com/alterhealthSome highlights from today's MM episode...Managing allergy symptoms (+ cold/URI) naturally with steam inhalation,  netti pot, and alternating hot/cold compressThe allergy/anti-histamine herbs and nutrients like nettles, butterbur, eyebright, quercetin, Vit C, NACReducing the load of environmental triggers by removing shoes indoors, washing sheets regularly, dusting/vacuuming, HEPA air filter, etcThe importance of balancing Th1 and Th2 immune responses - resolving system inflammation, avoiding immunogenic foods, gut healing, exposure to bacteria/virusesUnderstanding the stress response and its role in the immune systemLinks to some more good stuff-  Join Alter Health on Locals: https://alterhealth.locals.com/- Cleanse with Us during the next Alter Health Cleanse: https://www.alter.health/cleanse- Work with us in the Thrive on Plants program: https://www.alter.health/thrive-on-plants- ATTN Health Practitioners! Learn more and apply to the Plant Based Mind Body Practitioner Program: https://www.alter.health/pbmb-practitionerPeace and Love.

In this episode, Dr. Carmen explains how cortisol helps regulate the immune systems TH1 and TH2. What TH1 combats for us and how cortisol impacts it. What TH2 combats and again how cortisol impacts it. Understanding this relationship can help us better understand our labs, how we fight chronic and why we can't (sometimes) fight chronic infection. TH1, TH2, and Cortisol relationship impacts our health, energy, recovery, and the ability for our body to get fitter. If you want to take this work deeper, and apply it to your life we invite you to join us in the New Beginnings Program. We take this work apply it to your daily life, practice it. Unwinding the beliefs that don't serve you and go to work creating ones that move your life to that place you want it to be. Click here for more information: https://www.kimberlyjarmancoaching.com/the-path-to-success-program/ If you are ready to jump in click here to schedule a complimentary consultation call: https://calendly.com/kimberlyjarmancoaching/free-consultation-call For more information about working with Dr. Carmen Jones ND https://www.drcarmenjones.com

HIGHLIGHTS[00:48] Relating the winter Olympics to the nobility of the sports[05:15] Unravelling Nathalie's identity, purpose in life and her passion for sharing information[09:05] Living a life of gratitude in a world of abundance but not contentment[11:35] What is a peptide? What does it do to the body?[17:35] The proper way of introducing peptides to the body[21:49] A starter peptide that may work for an individual who just started to take a peptide[26:00] What is a Th1 and Th2 cell?[34:30] Utilizing both conventional and alternative medicine to provide medical solutions[38:15] Bioregulator peptides and the untapped benefits it provides to the body[43:35] Getting your hands on a peptide[50:14] Natalie relates her experience with peptides and the most profound benefits it has[56:06] The unquantifiable effects of good sleep and Nathalie's hacks for a great sleepUPGRADE YOUR WELLNESSClaim your free toxicity consult through this LINKAMD Ion Cleanse: https://calendly.com/ioncleanse/detoxCellcore - https://freddiesetgo.com/favorites/cellcore/ My favorite BindersLightPath LED https://lightpathled.com/?wpam_id=2 Discount Code - beautifullybrokenCelsius Network Website - https://celsius.network/ My Fav CRYPTO BankingBioStrap:https://biostrap.com/order-evo?ref=freddiekimmelp My Favorite Recovery Tracker Discount: BEAUTIFULLYBROKENUpgraded Formulas: LINK Code: FREDDIE10CONNECT WITH FREDDIECheck out my website and download “The Beautifully Broken Buyer's Guide” - https://freddiesetgo.com/Join my membership program -https://www.buymeacoffee.com/freddiesetgoInstagram - https://www.instagram.com/freddiesetgo/

Today I'm with guest Dr Rahul Vangala This episode gets straight to the point in answering the grand question of “Why does a mother's immune system not reject a developing baby as foreign tissue?” Dr. Rahul Vangala's most interesting answer is compared to a person's rejection of organ transplants. He explains that along with the immune changes a mother experiences, the placenta's close knit anatomy is a certain immune privilege site that has the attributes of a nematode using neurokinines in order to remain “hidden” and not be detected by the host. If the host's body cannot recognize foreign substances, then it lacks the ability to enable defense mechanisms that would attack that foreign material. This is most favorable for a fetus and perpetuates gestation. He moves on to break down the complex immune responses our bodies have antigens, or foreign materials, by mentioning the main role of the TH1 T Helper Cell and it's critical function to rejecting organs. Dr. Vangala mentions this because during pregnancy it necessary that there be an ideal degree of immune suppression of TH1 responses by the presence of TH2 responses. Not only are TH1 cells suppressed but Natural Killer cells are also dampened. He then goes on to explain how the beginning stages of the placenta during implantation resembles a semi-allograft meaning that the tissues grafted in are only partially foreign. The two doctors then discuss a major topic of autoimmune disorders and the complications of attempting to get pregnant. They unveil the way the autoimmune diseases decrease the likelihood of an optimal environment for viable gestation. Although, it is not impossible for women who live with autoimmune disorders to get pregnant and deliver a health baby. However, all in all there are many adjustments to the mechanics in order to make what we see as precious miracles. #immunechanges #placenta #pregnancy #immunesystem #TCells #THelperCells #semiallograft #autoimmune #graft #host #Surrogacy #AllergyImmunology #Rashes #Hives #Hormones

Dr. Karla Mehlenbacher Founder of Take Root Brain & Body joins us today, she is also a Board Certified Chiropractic Neurologist, and a Holistic Auto-Immune Practitioner. She had an auto-immune disease as a child and a later discovery of Lyme Disease. This is what drew her into holistic health and healing. She has multiple degrees in anatomy, biology and clinical neuroscience. She weaves perspectives from all of these disciplines to support full body wellness. She uses integrative neurology and functional medicine to help people struggling with post concussion syndrome, childhood developmental disorders, chronic pain, and many other neurological and auto-immune conditions. Her hope is to build a community where anyone suffering from chronic illness can seek wellness and feel supported by a wide variety of resources specific to the healing journey.     In this episode, we discuss: Dr. Karla's auto-immune disease and what lead her to holistic health Is auto-immune rooted in childhood trauma? Self Regulation – children vs. adults What is Lyme disease and who is susceptible to it? TH1, TH2 & Parasites When she found functional neurology Childhood disorders she treats   Work with Jennifer Get 25% Off a Private Coaching Session with me Sign-up for the Newsletter and stay up to date on my latest workshops, services, and speaking events.  Become a Member & Support the Illuminated Podcast on Patreon FREE 1 Year Supply of Vitamin D + 5 Travel Packs from Athletic Greens when you use My exclusive offer: AthleticGreens.com/Illuminated  Work with Dr. Karla Mehlenbacher Book an appointment for a consultation Find out more about Functional Medicine   Connect with Jennifer Website Patreon YouTube Facebook Instagram   Connect with  Website     Facebook Instagram

Besides 2-methoxy-17beta-estradiol, cell cycle arrest via chromatin deacetylation can mitigate cell proliferation by decreasing global transcription while promoting the expression of tumor suppressor genes like p16INK4a while DNA Damage Repair (DDR) from pro-inflammatory cytokine production from senescent cells and Th1 lymphocytes can inhibit commitment to mitosis and cytokinesis by generating the paracrine SASP paradigm. Refs. Am J Physiol Cell Physiol 2012;302:C1026-C1034 Steroids Volume 75, Issue 10, October 2010, Pages 625-631 Oncotarget. 2013 Oct; 4(10): 1552–1553 Cancer Metastasis Rev. 2020; 39(3): 681–709 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message Support this podcast: https://anchor.fm/dr-daniel-j-guerra/support

This is the tenth of a series of short videos on Low dose Medicine and in particular Cytokines. This video introduces the cytokine Interleukin 12. IL 12 is also known as a T cell-stimulating factor because it can stimulate the growth and function of T cells and especially the differentiation of naive T cells into Th1 cells (cell mediated immunity). IL-12 enhances the cytotoxic activity of NK cells and CD8+ cytotoxic T lymphocytes and also induces the synthesis of IFN-gamma, IL2, and TNF-alpha (TNF-α). IL-12 inhibits the synthesis of IgE induced by IL-4 and can therefore be useful in allergic diseases. IL 12 has anti-angiogenic (it can block the formation of new blood vessels), anti-tumoral and anti-metastatic activity, and because of this, it has been proposed by immunologists as a possible anti-cancer drug (although in pharmacological doses it can cause many side-effects). IL 12 is the most important cytokine with IL 2 and interferon gamma (IFN-gamma) in neoplastic pathologies (cancer support therapy) in general and especially melanomas and kidneys carcinoma. More information about this and other health topics can be found in my books "Low Dose Medicine" and "Cure Without Side effects" by following these links: ►►►https://amzn.to/3Bbx8fd ►►►https://amzn.to/36iaqDU To check the Low dose Medicine health kit follow this link: ►►►https://kit.co/cureswithoutsideffect/low-dose-medicine DISCLAIMER: Nothing contained in this video is intended nor can be taken to diagnose, treat, or cure any disease. It is for informational purposes only. This episode is also available as a blog post: https://cureswithoutsideffects.wordpress.com/2021/11/17/cytokines-series-interleukin-12-the-allergy-support-cytokine/ --- Send in a voice message: https://anchor.fm/cureswithoutsideeffects/message

This is the ninth of a series of short videos on Low dose Medicine and in particular Cytokines. This video introduces the cytokine Interleukin 10. IL10 regulates the reactivity of the organism and inhibits the synthesis of most pro- inflammatory cytokines such as IL1, IL6, IL8, IL12, IL23 and tumor necrosis factor (TNF) and also the Th1 sub populations of T-cells such as IFN-gamma and IL2. IL 10 regulates cell cycles and prevents nitric oxides and oxidative stress, it suppresses metastasis and tumor invasion. Since it inhibits the release of IL 1 and TNF it is able to slow down cartilage erosion. IL-10 can stimulate the synthesis of IgE antibodies and acts synergically with IL 4 to inhibit cell mediated immunity. It also prevents insulin resistance and insulin sensitivity. More information about this and other health topics can be found in my books "Low Dose Medicine" and "Cure Without Side effects" by following these links: ►►►https://amzn.to/3Bbx8fd ►►►https://amzn.to/36iaqDU To check the Low dose Medicine health kit follow this link: ►►►https://kit.co/cureswithoutsideffect/low-dose-medicine This episode is also available as a blog post: https://cureswithoutsideffects.wordpress.com/2021/11/12/cytokines-series-interleukin-10-the-master-anti-inflammatory-cytokine/ DISCLAIMER: Nothing contained in this video is intended nor can be taken to diagnose, treat, or cure any disease. It is for informational purposes only. --- Send in a voice message: https://anchor.fm/cureswithoutsideeffects/message

Why You Should Listen: In this episode, you will learn about the numerous contributors to conditions associated with brain inflammation. About My Guest: My guest for this episode is Dr. Kenneth Bock. As a leader in integrative medicine, Kenneth Bock, MD has accumulated over 35 years of experience diagnosing the root cause of chronic illnesses and restoring balance to his patients' immune systems. He founded Bock Integrative Medicine in response to the increasing need for board-certified medical providers who take a unique “whole body” approach to diagnosing and treating chronic illness. Dr. Bock is a well-respected integrative medicine doctor and autism expert who focuses on the treatment of autism and co-occurring conditions, PANS/PANDAS, Infection-Triggered Autoimmune Brain Inflammation, tick-borne illnesses, and adult conditions such as Chronic Fatigue Syndrome, Fibromyalgia, and heart disease. He integrates alternative modalities with conventional medicine into a comprehensive integrative medicine practice. His natural curiosity and expertise in working with medical problems that have been difficult to diagnose and treat make him sought after by patients throughout the world as an expert at tackling complex medical problems. Key Takeaways: How often do psychiatric conditions find themselves rooted in underlying biological factors such as infections and environmental toxicants? What is Infection-Triggered Autoimmune Brain Inflammation (ITABI)? What is Mood Dysregulation Spectrum and the symptoms that may present? What are some of the common nutrient deficiencies observed? How can immune tolerance be improved? Is it the bug or the host response that makes the disease? What are the common infections seen in ITABI? What tools can be helpful in quenching the fire of inflammation? What role do Th1, Th2, Th17, and Treg cells play? How can intestinal barrier function be improved? What role does the vagus nerve play in healing? How are the underlying triggers for PANS or ITABI identified? Can CBD be helpful for neuroinflammation? Is IVIG a helpful tool in children with ITABI? Which Lyme-associated microbe is the hardest to treat? Does mold exposure in water-damaged building play a role? What is the role of evaluating and supporting mitochondrial function in ITABI recovery?   Connect With My Guest: https://BrainInflamed.com https://BockIntegrative.com Related Resources: https://BockNutritionals.com Interview Date: September 29, 2021 Transcript: To review a transcript of this show, visit http://BetterHealthGuy.com/Episode153 Additional Information: To learn more, visit http://BetterHealthGuy.com. Disclaimer: The content of this show is for informational purposes only and is not intended to diagnose, treat, or cure any illness or medical condition. Nothing in today's discussion is meant to serve as medical advice or as information to facilitate self-treatment. As always, please discuss any potential health-related decisions with your own personal medical authority.

Investigating the anti-hypertensive effects of pumpkin seed oil Marymount University and University of Guilan (Iran), September 29, 2021 In a study, researchers from Iran and the U.S. found that pumpkin seed oil can potentially treat hypertension in postmenopausal women. Their report was published in Complementary Therapies in Clinical Practice. Postmenopausal women are more likely to develop hypertension than men of the same age. In vivo studies reveal that pumpkin seed oil has anti-hypertensive activity. The team investigated the effects of pumpkin seed oil supplementation on vascular function and heart rate variability in postmenopausal women with elevated blood pressure. Participants were assigned to take either a pumpkin seed oil supplement or a placebo for the six-week study. Those in the experimental group took 3 grams of pumpkin seed oil every day. Brachial and central blood pressure, wave reflection (augmentation index, AIx), arterial stiffness (SI) and various HRV parameters were measured at baseline and at the end of the study. Those who took pumpkin seed oil had significantly lower AIx, brachial and systolic blood pressure after treatment. SI and HRV parameters remained unchanged for the treatment group and the placebo group at the end of the study. In sum, taking pumpkin seed oil may improve arterial hemodynamics in postmenopausal women.     Health benefits of evening classes revealed   Oxford University, September 20, 2021    Those with a taste for adult education classes have long known it, but now Oxford University scientists have confirmed that taking part in the weekly sessions can boost wellbeing – regardless of the subject studied.   In partnership with the Workers' Educational Association (WEA), the largest voluntary sector provider of adult education in England and Scotland, a team from Oxford's department of experimental psychology studied attendees at seven separate day-time adult education classes. Their findings are published in a series of papers.   Each class took place over seven months and included a break in the middle. Attendees completed questionnaires before and after their class three times over the seven months: at the beginning of their courses, after 3 months, and at the end of the seven months. Participants were involved in one of three activities: singing, crafts or creative writing.   Overall, attendees at all seven classes had improved mental and physical health and reported more satisfaction with their lives at the end of their courses.   Dr Eiluned Pearce led the research. She said: 'The students reported benefits including increased self-confidence, a greater feeling of control over their lives and more willingness to take on new challenges. Some said the classes made them more motivated to be more active, despite the classes not specifically involving physical activity.   'Participants also said that the classes broadened their networks of friends and gave them an increased sense of belonging. We also found that the more someone felt part of their group, the more their health and wellbeing improved.' An intriguing finding was in the singing and creative writing classes. Building on the results of an earlier paper from the same study, which found that people in singing classes felt closer to their group more quickly than those in the other classes, the team looked at how relationships formed between individuals in the classes.   Each person was asked to name those other people in the class whose name they could remember, whether or not they felt connected to each person they named, and whether they had talked to that person during class.   Dr Pearce said: 'The results showed that those in the singing and creative writing groups built up relationships with other individuals more quickly than the crafters, and singers felt more connected to the class as a whole more quickly than both the other groups. 'While this confirms our earlier finding that singing has an 'ice-breaker effect' compared to other activities, it shows that other activities may enable people to increase their social networks just as much, even if it takes them longer to feel connected to their group as a whole.'   Co-author Dr Jacques Launay adds: 'While much of our previous work has demonstrated the importance of music, it is likely that the most socially bonding activities are always those that are personally chosen and enjoyed. This research adds to growing support for the relevance of creative activities in creating happy communities and improving health and well-being, with consequent benefits for public services and society.'   Dr Pádraig Mac Carron, Dr Anna Machin and Professor Robin Dunbar were also involved in the research.   Howard Croft, WEA Regional Education Manager, said: 'The findings reiterate the feedback that we have had from our students over the years: learning is a fantastic way to boost your self-esteem and confidence. Also of note, is its therapeutic effect. For many students, creative courses are a means of finding a new outlet for expressing their feelings. This can be of immense help during times of personal difficulty or emotional upheaval, such as divorce or bereavement. Simply going to a course can offer much-needed respite.   'For others, learning can be an opportunity to reignite a former passion. This could be anything from a subject which you enjoyed at school to an area which you are interested in. Whatever your reason, there are so many benefits to be gained by signing up to a course.'       Want to live forever? Theoretically, you could, study says Swiss Federal Institute of Technology, September 29, 2021 Humans can probably live to at least 130, and possibly well beyond, though the chances of reaching such super old age remain vanishingly small, according to new research. The outer limit of the human lifespan has long been hotly debated, with recent studies making the case we could live up to 150 years, or arguing that there is no maximum theoretical age for humans. The new research, published Wednesday in the Royal Society Open Science journal, wades into the debate by analyzing new data on supercentenarians—people aged 110 or more—and semi-supercentenarians, aged 105 or more. While the risk of death generally increases throughout our lifetime, the researchers' analysis shows that risk eventually plateaus and remains constant at approximately 50-50. "Beyond age 110 one can think of living another year as being almost like flipping a fair coin," said Anthony Davison, a professor of statistics at the Swiss Federal Institute of Technology in Lausanne (EPFL), who led the research. "If it comes up heads, then you live to your next birthday, and if not, then you will die at some point within the next year," he told AFP. Based on the data available so far, it seems likely that humans can live until at least 130, but extrapolating from the findings "would imply that there is no limit to the human lifespan," the research concludes. The conclusions match similar statistical analyses done on datasets of the very elderly. "But this study strengthens those conclusions and makes them more precise because more data are now available," Davison said. The first dataset the team studied is newly released material from the International Database on Longevity, which covers more than 1,100 supercentenarians from 13 countries. The second is from Italy on every person who was at least 105 between January 2009 and December 2015. 'One in a million' The work involves extrapolating from existing data, but Davison said that was a logical approach. "Any study of extreme old age, whether statistical or biological, will involve extrapolation," he said. "We were able to show that if a limit below 130 years exists, we should have been able to detect it by now using the data now available," he added. Still, just because humans can theoretically reach 130 or beyond, doesn't mean we're likely to see it anytime soon. For a start, the analysis is based on people who have already achieved the relatively rare feat of making it to well over 100. And even at age 110, your chances of making it to 130 are "about one in a million... not impossible but very unlikely," said Davison. He thinks we could see people reaching 130 within the century, as more people make it to supercentenarian status, increasing the chances of one becoming that one in a million. "But in the absence of major medical and social advances, ages much over this are highly unlikely ever to be observed," he added. For now, the oldest person on record is Frenchwoman Jeanne Calment, who died in 1997 at the confirmed age of 122. Her true age was the subject of some controversy, with claims of a possible fraud, but in 2019 several experts said a review of the evidence confirmed her age. Other pretenders to the throne of oldest person ever have a long way to go. The oldest verified living person in the world is Japan's Kane Tanaka, a comparatively youthful 118.     Psychological treatment shown to yield strong, lasting pain relief, alter brain networks University of Colorado, September 29, 2021 Rethinking what causes pain and how great of a threat it is can provide chronic pain patients with lasting relief and alter brain networks associated with pain processing, according to new University of Colorado Boulder-led research. The study, published Sept. 29 in JAMA Psychiatry, found that two-thirds of chronic back pain patients who underwent a four-week psychological treatment called Pain Reprocessing Therapy (PRT) were pain-free or nearly pain-free post-treatment. And most maintained relief for one year. The findings provide some of the strongest evidence yet that a psychological treatmentcan provide potent and durable relief for chronic pain, which afflicts one in five Americans. "For a long time we have thought that chronic pain is due primarily to problems in the body, and most treatments to date have targeted that," said lead author Yoni Ashar, who conducted the study while earning his Ph.D. in the Department of Psychology and Neuroscience at CU Boulder. "This treatment is based on the premise that the brain can generate pain in the absence of injury or after an injury has healed, and that people can unlearn that pain. Our study shows it works." Misfiring neural pathways Approximately 85% of people with chronic back pain have what is known as "primary pain," meaning tests are unable to identify a clear bodily source, such as tissue damage. Misfiring neural pathways are at least partially to blame: Different brain regions—including those associated with reward and fear—activate more during episodes of chronic pain than acute pain, studies show. And among chronic pain patients, certain neural networks are sensitized to overreact to even mild stimuli. If pain is a warning signal that something is wrong with the body, primary chronic pain, Ashar said, is "like a false alarm stuck in the 'on' position." PRT seeks to turn off the alarm. "The idea is that by thinking about the pain as safe rather than threatening, patients can alter the brain networks reinforcing the pain, and neutralize it," said Ashar, now a postdoctoral researcher at Weill Cornell Medicine.or the randomized controlled trial, Ashar and senior author Tor Wager, now the Diana L. Taylor Distinguished Professor in Neuroscience at Dartmouth College, recruited 151 men and women who had back pain for at least six months at an intensity of at least four on a scale of zero to 10. Those in the treatment group completed an assessment followed by eight one-hour sessions of PRT, a technique developed by Los Angeles-based pain psychologist Alan Gordon. The goal: To educate the patient about the role of the brain in generating chronic pain; to help them reappraise their pain as they engage in movements they'd been afraid to do; and to help them address emotions that may exacerbate their pain.  Pain is not 'all in your head' "This isn't suggesting that your pain is not real or that it's 'all in your head'," stressed Wager, noting that changes to neural pathways in the brain can linger long after an injury is gone, reinforced by such associations. "What it means is that if the causes are in the brain, the solutions may be there, too." Before and after treatment, participants also underwent functional magnetic resonance imaging (fMRI) scans to measure how their brains reacted to a mild pain stimulus. After treatment, 66% of patients in the treatment group were pain-free or nearly pain-free compared to 20% of the placebo group and 10% of the no-treatment group. "The magnitude and durability of pain reductions we saw are very rarely observed in chronic pain treatment trials," Ashar said, noting that opioids have yielded only moderate and short-term relief in many trials. And when people in the PRT group were exposed to pain in the scanner post-treatment, brain regions associated with pain processing—including the anterior insula and anterior midcingulate —had quieted significantly. The authors stress that the treatment is not intended for "secondary pain"—that rooted in acute injury or disease. The study focused specifically on PRT for chronic back pain, so future, larger studies are needed to determine if it would yeild similar results for other types of chronic pain.  Meanwhile, other similar brain-centered techniques are already ememrging among physical therapists and other clinicians who treat pain. "This study suggests a fundamentally new way to think about both the causes of chronic back pain for many people and the tools that are available to treat that pain," said co-author Sona Dimidjian, professor of psychology and neuroscience and director of the Renee Crown Wellness Institute at CU Boulder. " It provides a potentially powerful option for people who want to live free or nearly free of pain."     Citicoline (CDP-choline) and Memory Function in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial  Kyowa Hakko Bio (Japan), September 2021 Supplementation of citicoline (CDP-choline), a naturally occurring mononucleotide, has shown beneficial effects on memory function and behavior in populations with a wide range of impairments. However, few studies have investigated its effect in healthy older populations. Objective The objective of this study was to investigate the effects of citicoline, on memory in healthy elderly populations with age-associated memory impairment (AAMI). Methods A total of 100 healthy men and women aged between 50 and 85 y with AAMI participated in this randomized, double-blind, placebo-controlled trial. Participants were randomized to receive placebo (n = 51) or citicoline (n = 49; 500 mg/d) for 12 wk. Memory function was assessed at baseline and end of the intervention (12 wk) using computerized tests (Cambridge Brain Sciences, Ontario, Canada). Safety measurements included adverse events query, body weight, blood pressure, and hematology and metabolic panel. Intent-to-treat analysis was conducted using ANCOVA for the primary and secondary outcome variables with Bonferroni correction for multiple comparisons. Results A total of 99 out of 100 participants completed the study in its entirety. After the 12-wk intervention, participants supplemented with citicoline showed significantly greater improvements in secondary outcomes of episodic memory (assessed by the Paired Associate test), compared with those on placebo (mean: 0.15 vs. 0.06, respectively, P = 0.0025). Composite memory (secondary outcome), calculated using the scores of 4 memory tests, also significantly improved to a greater extent following citicoline supplementation (mean: 3.78) compared with placebo (mean: 0.72, P = 0.0052). Conclusions Dietary supplementation of citicoline for 12 wk improved overall memory performance, especially episodic memory, in healthy older males and females with AAMI. The findings suggest that regular consumption of citicoline may be safe and potentially beneficial against memory loss due to aging.      Sleep may strengthen long-term memories in the immune system   University of Tuebingen (Germany) September 29, 2021   More than a century ago, scientists demonstrated that sleep supports the retention of memories of facts and events. Later studies have shown that slow-wave sleep, often referred to as deep sleep, is important for transforming fragile, recently formed memories into stable, long-term memories. Now, in an Opinion article published  in Trends in Neurosciences, part of a special issue on Neuroimmunology, researchers propose that deep sleep may also strengthen immunological memories of previously encountered pathogens.   "While it has been known for a long time that sleep supports long-term memoryformation in the psychological domain, the idea that long-term memory formation is a function of sleep effective in all organismic systems is in our view entirely new," says senior author Jan Born of the University of Tuebingen. "We consider our approach toward a unifying concept of biological long-term memory formation, in which sleep plays a critical role, a new development in sleep research and memory research."   The immune system "remembers" an encounter with a bacteria or virus by collecting fragments from the bug to create memory T cells, which last for months or years and help the body recognize a previous infection and quickly respond. These memory T cells appear to abstract "gist information" about the pathogens, as only T cells that store information about the tiniest fragments ever elicit a response. The selection of gist information allows memory T cells to detect new pathogens that are similar, but not identical, to previously encountered bacteria or viruses.   Studies in humans have shown that long-term increases in memory T cells are associated with deep slow-wave sleep on the nights after vaccination. Taken together, the findings support the view that slow-wave sleep contributes to the formation of long-term memories of abstract, generalized information, which leads to adaptive behavioral and immunological responses. The obvious implication is that sleep deprivation could put your body at risk.   "If we didn't sleep, then the immune system might focus on the wrong parts of the pathogen," Born says. "For example, many viruses can easily mutate some parts of their proteins to escape from immune responses. If too few antigen-recognizing cells [the cells that present the fragments to T cells] are available, then they might all be needed to fight off the pathogen. In addition to this, there is evidence that the hormones released during sleep benefit the crosstalk between antigen-presenting and antigen-recognizing cells, and some of these important hormones could be lacking without sleep."   Born says that future research should examine what information is selected during sleep for storage in long-term memory, and how this selection is achieved. In the end, this research could have important clinical implications.   "In order to design effective vaccines against HIV, malaria, and tuberculosis, which are based on immunological memory, the correct memory model must be available," Born says. "It is our hope that by comparing the concepts of neuronal and immunological memory, a model of immunological memory can be developed which integrates the available experimental data and serves as a helpful basis for vaccine development."         Standardized astragalus extract for attenuation of the immunosuppression induced by strenuous physical exercise: randomized controlled trial University of Physical Sciences (Poland), September 3, 2021 This paper aimed to verify how a supplementation of rower's diet with Astragalus Membranaceus Root (AMR) modulated their immune system response to maximal physical exertion. Methods The double-blind study included 18 members of the Polish Rowing Team assigned to the supplemented group (n = 10), and the placebo group (n = 8). The participants performed a 2000 m test on a rowing ergometer at the beginning and at the end of the six-week of intensive training camp during which the supplemented group received 500 mg of AMR. Blood samples were obtained prior to, 1 min after completing, and 24 h after the exertion test. The levels of interleukin 2 (IL2), interleukin 4 (IL4), interleukin 10 (IL10), interferon ɤ (IFN-ɣ), and lactic acid were determined. Subpopulations of T regulatory lymphocytes [CD4+/CD25+/CD127−] (Treg), cytotoxic lymphocytes [CD8+/TCRαβ+] (CTL), natural killer cells [CD3−/CD16+/CD56+] (NK), and TCRδγ-positive cells (Tδγ) were determined with flow cytometry. Results After the camp, the initial NK and Treg levels sustained at the baseline, while Tδγ counts increased relative to the levels in the placebo group. In the supplemented subgroup, a decrease in IL2 level in reaction to maximal exertion clearly deepened while the change in IL-2/IL-10 level induced by the recovery after this exertion clearly increased, relative to the changes in the placebo group. Conclusions AMR restored the immunological balance in strenuously trained athletes through a stabilization of NK and Treg cells with a positive trend in Tδγ towards Th1 response during restitution by cytokine IL2 modulation.

Macrophage polarization and differentiation works in conjunction with CD4+ T lymphocyte differentiation into Th1 and Th2 subclasses and both NK and B cell activities. The aging human loses feedback control over the pro-inflammatory and anti-inflammatory pathways from these classical cellular differentiations contributing to hyperinflammation and/or hypoinflammatory responses ultimately resulting in pathological cell degeneration or proliferation, morbidity and death. Dr. Daniel J. Guerra Authentic Biochemistry Production. 18.9.21. Reference Nature Immunology June 2018 19: 561–570 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message Support this podcast: https://anchor.fm/dr-daniel-j-guerra/support

這集感謝網友幫我做筆記，讓我很快的可以整理好內容！大感謝！　 1.Pauline：分享英國疫苗工作組專家感想：當時牛津大學有很多計劃在進行，可以選擇要跟歐盟還是自己研發疫苗，後來選後者。在疫苗初期發展過程也是有遇到問題，但我們比歐盟提早三個月，所以有時間解決這些問題。當初也花四千兩百萬英鎊買斷印度的生產線，一開始也被問很多立場和政治取向，他也是很傷心，但是還是把救人放在第一位，研發設計疫苗就是讓英國全國都可以施打，還有全球，其他防疫方面也要進行不要忽略。此外輝瑞在英國區的經理提到，英國在批准和接種速度是前所未有，企業和政府都在分擔風險，是全國性的活動。所以今天聽到國產疫苗的進展很感動。 2.Nobuhiro：今天高端記者會感想：一般人最在乎就是有打安慰跟沒打的差別，但看完下午的資料看不太懂。 3.Yvonne：剛剛有提到疫苗的有效性除了中和抗體，也要考慮 TH1 T細胞的反應，請問臨床實驗上已有正式將 TH1 的 cytokines 如 TNFa 列為可量化的正式指標了嗎？本來 AZ 有要找台灣的 CDMO 代工，但產能沒有做到國際要求，會不會覺得很可惜，有哪些面向是可以加強的，以後也有機會接到單子？ 04b：報導者有報導過國衛院牽線想代工，今天阿中記者會證實了此事，要求是要年產三億，但我們只能一億。另外還有萬一接了單，國產疫苗就沒辦法量產了，現在回頭看新冠疫苗的策略，國外幾乎都是先外購，再來代工，最後就是扶植國產。可以參考鄰近兩國例子，想一下如果先代工，可能會不一樣。今天也有說我們想代工莫德納，陳培哲老師也有說蛋白疫苗很難做也花時間，所以可以回頭討論這樣做是不是有可以改進的空間。 疫苗新布局：爭取牛津授權、台廠代工有望，國家隊產能為何恐受影響？ 04b：中和抗體也沒有標準化，更何況是更難做的 T 細胞相關，這也是麻煩的地方。WHO 也沒討論到 TH1 指標。 這樣如果要跟國際接軌？ 04b：不用太擔心，就給大人決定，總會有個出路的。後面還有這麼多疫苗，卡在高端聯亞一樣的狀況，目前的疫苗明顯不夠供給全世界，WHO 的立場應該是會解決這件事。 4.台灣佈局的疫苗數量就是不夠一千五百萬人接種兩劑，疫苗做出來的數據也沒有國際通用的標準，不知道國產跟 AZ 的血清比結果如何，但現在就是不能比別人差，目前的佈局會達到群體免疫嗎，如果不行要怎麼控制下來？ 04b：時勢所逼還是會持續買疫苗，進入下半年會不會進入賣家市場，可能會比較容易買到，狀況可能會改變。 5.日本代工疫苗： 日本有 AZ，武田有申請莫德納，但不知道會不會做，Novavax 確定有代工。 Shuman：武田如果代工莫德納預計最快第三季會開始生產，台灣如果有需要會是第一優先合作夥伴。 6.Wendy：美國疫苗現在是過剩，會大幅度加快供應。聽說台灣做 PCR 測試 CT 值降低了，測出來的人就會少一點？ 04b：我們出院的標準是 30，跟檢測不一樣，台灣的資料在康復者追蹤的PCR做到 30 以上幾乎沒有活病毒。現在美國 CDC 不用 follow PCR，台灣還是有點小心，十天後如果沒症狀，CT 值 30 以上就可以回去。追蹤和確診不一樣，目前確診陽性是訂在 35，但如果 35~40 之間還是有機會判定陽性。 7.Ariel：國產疫苗有預計去印度或巴西做第三期嗎？ 04b：高端計畫去印度，聯亞計畫去中美洲，有計劃，目前不知道是否真的會成行。今天高端也說想做第三期，困難的是，第二期作完前不能直接審，再來是跨國的臨床實驗資金，言下之意好像又不會去做了。有去跟歐盟諮詢，第二期做到這樣，如果想在歐盟做臨床或正式申請，可以做哪些規劃。 8.一開始設計是原始株，不是針對變種，這樣對變種病毒是否有效？ 04b：可以在實驗室做，國產兩家都有在做了，初期報告跟國際疫苗有點像，雖然中和抗體有掉下來，但都在有保護的範圍內。如果真的要認證有沒有效，還是要做臨床。現在莫德納也是實驗做一做就說有效，理論上可以保護，就繼續了，沒有做臨床試驗。因為在南非臨床就做出中和抗體下降特別多，不管是輝瑞莫德納 Novavax 就有在研發下一代疫苗。 04b 爆卦：何美鄉老師說他比調擔心聯亞，兩家都是蛋白質，但因為聯亞是小分子， 很小很小的分子要產生抗體是很難的。高端有兩個佐劑，抗體可能產生比較好。老師有參加聯亞的人體實驗。 9.Sarah：有人問部長說英國病毒株是否可預防，部長說可能會打到三劑。另外下星期 75 歲長輩就會開始接種，由區公所統籌，請民眾稍安勿躁，是以戶籍地做通知對象。 04b：英國變種病毒沒有明顯免疫逃逸現象，各大疫苗廠都做了實驗室的中和抗體，本身疫苗是有效的，原本是針對武漢株，但沒有免疫逃逸。阿中說的第三針，在蛋白疫苗理論上是可行的，蛋白疫苗相對比較安全。B 肝疫苗也是要打三針，中國滅活疫苗也有在想要不要打三針。今天衛福部有評估報告，未來要因應變種病毒，因為蛋白疫苗的速度慢，曠日費時，mRNA 是調整最快的，六個星期內就可以做出新的疫苗，所以今天就有討論是否要代工。未來病毒一直變，可能還是要 mRNA 才能應變。 衛福部：建立核酸疫苗自主生產技術刻不容緩 爭取疫苗代工！ 陳時中：已向莫德納表達「有興趣與有能力」 10.Po Chun：高端計畫去荷蘭、連亞去印度做三期，以現在的時空環境，雙北地區是否可做三期的場域？美國去年就補助藥廠研發，但台灣有點像是里程碑式的補助，前面的研發過程就是民間企業要承擔，如果政府補助很大筆錢，會有圖利的疑慮，對比美國是更超前在補助疫苗廠。 04b：美國是神速計畫，要不是川普投資這麼多，疫苗不會做這麼快做出來。回頭來想新冠疫苗的策略，目前做出來的也就那幾國，日本也沒做出來。我們是否一定要做出自己培植國產，日韓走代工，但沒放棄走國產，日本投入的金額一樣是我們的幾倍之多，有六家藥廠，前期一樣也是搶代工，他們生技產業技術在我們之上，連他們都是這樣做，我們的佈局是否太保守，歐洲這麼多國也只有英國做出國產。可能台灣有買不到疫苗的問題，但國產真的做得出來嗎，也不是很確定的事情。 雙北做三期？看之後疫情控制到什麼程度，就算做三期，也不是做原來的三期（食鹽水組）所以 WHO 在想要改變這件事，可能要正式上市的疫苗相比，現在很多新藥都是這樣，證明沒有比他差，怎麼證明，測中和抗體或兩邊到底多少人得病，也可以要做比他好的設計，但藥廠通常不敢做這樣的設計。現在真的是不確定的時候，未來看法規單位會怎麼要求第三期、給 EUA、甚至上市。 11.Howard：感覺疫苗實驗的人數、安全性、保護力以及相關的副作用，會是專家或民眾考量疫苗是否可信或是願意施打的原因，目前國內疫苗的中和抗體幾何平均效價與國外的定義不太相同，該如何正確判斷及比較國內外疫苗的安全性或保護力呢？ 04b：中和抗體做法每個臨床實驗都不一樣，現在沒有訂出一個中和抗體要怎麼測的標準，流感早就訂出來了。每家臨床的數據不能互相比較，現在想出來的方法是用康復者血清比，現在可能會往這個方向去，但不知道 WHO 會不會訂出來。台灣想出來的是跟某個疫苗，像是AZ比。 12.Nathan：COVID-19 疫苗注射完，抗體消退後或病毒一直變種 etc，如果接下來要一直打，每年都要補打，目前為什麼要一直擔心國產疫苗跟國際接軌的問題？策略是先代工的印度一月開打、日韓二月底開打，台灣四月開打真的有很慢嗎？ 04b：我也很糾結為什麼大家一直糾結打不到疫苗這件事，如果不是本土疫情爆發，應該大家還在嫌棄AZ的副作用吧。進入疫情前兩週媒體都在討論疫苗，瘋狂追疫苗，企業地方政府都去買，但明顯沒那麼好買，新聞炒了兩週，一場空，什麼都沒買到。處理現在的疫情，至少要先把檢驗量能提升，疫苗是最後，打完也不是沒事，打完還是上學前要檢測，還是有可能會得到。不要陷入打不到疫苗就焦慮，打到疫苗就沒事。也許年底明年就可以出國，如果是兩三年後，輝瑞滿街跑，沒有短缺，就不是問題，現在不用擔心。能否會跟國際接軌可以先放一旁，是否有效、能否為控制疫情出一份力，是目前比較重要的。 13.Trivien：請問得過武漢肺炎的人，痊癒之後還需要打疫苗嗎？請問打過高端疫苗的人，如果高端疫苗不被國際承認，要出國的話還可以打 AZ、輝瑞等四大疫苗嗎？ 04b：美國建議得過了都還是要打，打了產生的中和抗體是比康復者抗體還高，康復者的抗體是會慢慢消退的，有些無症狀也不知道你有沒有得過，反正就都打。台灣因為之前案例不多，沒有特別針對這個做建議，因為在疫苗短缺時候，得過新冠的人大概半年內是不用打的。第二個問題，混打，不知道。蛋白疫苗 EUA 最快的是 Novavax，英國有在做花式混打研究，目前台灣因為疫苗不夠，指揮中心說不能混打。但等可以出國的時候，也不知道狀況是怎樣，到那時候再來煩惱。 14.Nobuhiro、Shuman 分享日本打疫苗的政策和被浪費的疫苗 Nobuhiro：大家都想打疫苗，但把防疫做好比較實際。今天拿到了疫苗兌換券，要比賽搶到時段才能打。在日本從疫情到現在拿到疫苗兌換券，等了一年三個月。大家努力做好防疫比較重要。日本目標在秋季之前全部打完，要開放職場和學校可以打，多管齊下。 Shuman：現在只有東京圈的年輕人才有券。現在有產業醫的公司就可以打，包含員工眷屬。 Pauline：法國打法是先測抗體，有測到抗體，打一針。 Wendy：美國也有這樣推薦，但因為美國疫苗太多了，就沒有這樣做。 15.四X貓：問混打。一開始打好像有簽切結書，如果第二劑沒有AZ，要打別的疫苗。 04b：現在不能混打。切結書第二劑打有可能是打國產疫苗，但接下來 AZ 可能不會缺，後續日本可能還會送，原廠也有訂。第二劑莫德納就不用想了。英國是 AZ 和輝瑞的資料會先出來，AZ和莫德納混打的資料要再晚些。 16.Shuman：高雄說優先讓懷孕醫護打莫德納？ 04b：美國孕婦打 mRNA 有報告，有一定安全性。 Wendy：有研究，將近三萬六千個孕婦打的都挺安全，幾乎都是輝瑞莫德納，有一些 J&J。 04b：有一定安全性的報告，AZ 應該不是孕婦會出問題，是懷孕本身就有形成血栓的風險。莫德納本來就優先給第一線，看醫護要再怎麼分也可以。 Sarah：AZ 有四萬劑會留給自費第二劑劑的人施打。23 價公費肺炎鏈球菌疫苗 75 歲都還有量。台中有另外開放 60 歲以上，可能很快就打完了。提醒長輩待在家減少風險暴露。 高端 聯亞 國產疫苗懶人包 第二期結束就緊急授權可行嗎？ https://linshibi.com/?p=39547 新冠快篩懶人包 普篩 抗體快篩 抗原快篩 https://linshibi.com/?p=36564 新冠肺炎疫情下的防疫須知 常見問題解答FAQ https://linshibi.com/?p=35408 新冠疫苗常見問題懶人包 https://linshibi.com/?p=38945 林氏璧醫師的電子名片 https://lit.link/linshibi 歡迎贊助我喝咖啡 https://pay.firstory.me/user/linshibi Powered by Firstory Hosting

Is it the host or the bug that is most important? The worse thing you can do is weaken the immune system when there is a pandemic.  H1N1 changed its glycoprotein spike arrangement in 1915.  In 1918 , it was called the Spanish Flu and killed 675,000 Americans and 100 million Worldwide!  But the human immune system adapted and fought back.  In June 2009 H1N1 changed a bit again and killed 13,000 Americans.  I personally was very worried about H1N1 (still am). Its nastier than most. H1N1 still causes 90% of all FluA outbreaks and infections today!   But the human immune system adapted and fought back.  Herd immunity as a group, better Th1 & Th2 and Killer T cells as an individual put us back on top of the food chain.  Natural selection rocking us on!  Dr. Fred Clary, founder of Functional Analysis Chiropractic Technique and lifting and life coach and gym chalk covered philosopher opens a conversation on the history of a pandemic. Prayers and positive thoughts to all those affected physically, emotionally, economically and spiritually by the current crisis!  

Using Spore-Based Probiotics (Sporebiotics) to Improve Your Health - Live Podcast #157 Get Show Updates Here: http://www.beyondwellnessradio.com/newsletter  Show Transcription: https://justinhealth.com/sporebiotics-to-improve-your-health-live-podcast-157/  You-tube Podcast Subscribe: http://www.youtube.com/subscription_center?add_user=justinhealth  In this podcast, Dr. Justin Marchegiani and Evan Brand digs deep into the topic of probiotics, or more specifically, spore-based probiotics (sporebiotics). Basically, the cell wall of these bacteria which is the spore is known for having awesome benefits of modulating the immune system. One of the benefits of probiotics or sporebiotics is the way it combats the negative effects of electromagnetic fields (EMFs). We may not beware of it, but constant exposure to EMF can actually increase the virulence of infections, parasites, and inflammation in the body, which is why we always try to boost the good bacteria in our system so we could counteract this negative effect. Also, learn about bacillus spores and how it prevents immune system problems like allergies, etc. For more information about the effects of spore-based probiotics, kindly watch this podcast. In this episode, we cover: 03:00             EMF's and Infections 06:29             L. Gasseri and Histamine 09:16             Th1, Th2 immune system and vaccines 18:55             Paleo template and bowel irregularity 24:48             Lectins Subscribe on I-Tunes: http://www.beyondwellnessradio.com/itunes  Review us at: http://www.beyondwellnessradio.com/itunes  Visit us at: http://www.beyondwellnessradio.com  Have a question: http://www.beyondwellnessradio.com/question  References: https://justinhealth.com/products/megasporbiotic/  https://justinhealth.com/products/probio-flora/  https://www.topochicousa.net/  https://www.drberg.com/blog/the-truth-on-vaccines 

Natural ways to strengthen your immune system – Podcast #66 Get Show Updates Here: http://www.beyondwellnessradio.com/newsletter Get the show transcripts here: http://justinhealth.com/natural-ways-to-strengthen-your-immune-system-podcast-66/ Dr. Justin Marchegiani and Evan Brand talk about the various natural ways we can do and supplements we can take to help boost our immune system, especially when we're experiencing an acute illness. Find out about what you can do to enhance your immune system and stay away from illnesses. There are a lot of techniques that you'll learn about how you can supercharge your immune system in this podcast. Dr. Justin breaks down the different branches of the immune system to help us better understand how it works. Learn about what Vitamins A, C, and D, zinc, and silver can do for the immune system as well as what medicinal mushrooms and adaptogenic herbs can do to help. In this episode, topics include: 5:28 foundational info for immune health 11:48 Th1, Th2, IgA, IgG, and IgM 14:16 herbs to boost immune system 17:34 flu viruses and the flu vaccine, symptoms and viruses 24:40 nutrients and vitamins Write us a review: http://www.beyondwellnessradio.com/itunes Visit us at: http://www.beyondwellnessradio.com Have a question: http://www.beyondwellnessradio.com/question