Podcasts about In Depth

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Best podcasts about In Depth

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Latest podcast episodes about In Depth

In Depth With Graham Bensinger
Skateboarding Legend

In Depth With Graham Bensinger

Play Episode Listen Later Oct 3, 2022 60:35


Graham goes In Depth with seven-time X Games medalist Ryan Sheckler as they spend two days together in Southern California in 2021. The former star of his own MTV reality show looks back on wild years as a teenager at the top of skateboarding, including celebrity-filled house parties and awkward breakups in front of TV cameras. Now married in his early 30s and expecting a child, Sheckler opens up about a drastically different lifestyle, focused on sobriety, abstinence and faith.

1010 WINS In Depth
The new controversial ketamine craze

1010 WINS In Depth

Play Episode Listen Later Sep 30, 2022 21:47


On this week's episode of In Depth we're joined by comedian Phillip Markle. While he's not a medical expert that can talk at length about the dangers of the drug, he is someone who undergoes ketamine therapy frequently. We also chat with Dr. John Mann, a professor of translational neuroscience in psychiatry and radiology at Columbia University.  Listen as we join Philip on one of his sessions and discuss the history of Ketamine in an effort to determine whether the drug has changed or our perception of it. Producers: Jill Webb and Dempsey Pillot Audio Engineer: Anddy Egan-Thorpe Host and Managing Producer of Podcasts: Femi Redwood 

KNX In Depth
KNX In Depth: Hurricane Ian lashes South Carolina as Florida relief efforts begin--Is southern California prepared for a natural disaster?--California young adults struggle with mental health--Record turkey prices ahead of Thanksgiving

KNX In Depth

Play Episode Listen Later Sep 30, 2022 48:04


Hurricane Ian is on the move again. It's smacking the coast of South Carolina right now, bringing winds and heavy rain to a state hoping it doesn't meet the same fate as Florida. Rescue groups and aid workers are combing through the wreckage and devastation left behind in Florida to assess the damage and help those in need. We go In Depth into Hurricane Ian.   The damage and destruction in Florida could happen here in southern California in the form of the Big One. Are we prepared for a major quake?   Russia formally takes land away from Ukraine following those referendums in occupied regions of Ukraine that have been called shams. Ukraine responds by trying to get into NATO that much quicker. We go In Depth into what's being labeled as a major escalation of the war.   We know the pandemic has taken a toll on mental health. But a new survey shows an alarming number of young adults in California dealing with anxiety, depression and suicidal thoughts.  A bad bird flu outbreak has led to a turkey supply issue which could have a major impact on your Thanksgiving dinner.  To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

The RCWR Show with Lee Sanders
Episode 971-Sarya Bombs on DYNAMITE! Malakai Black Getting Death Threats! The RCWR Show 9/28/22

The RCWR Show with Lee Sanders

Play Episode Listen Later Sep 30, 2022 136:18


411MANIA.COM reporter & columnist Lee Sanders is back with his AEW DYNAMITE September 28th live results & review as Sarya Knight speaks for the first time since arriving in AEW! Man did she bomb big time! MJF appears, Toni Storm vs Serena Deeb, latest in headlines including Malakai Black trying to clarify his AEW status while getting death threats! and more in action!!!-Rest in Peace Coolio. Dead at 59.-Shout out to listeners in Florida suffering from Hurricane Ian-AEW Dynamite Recap and takeaways-Naomi responds to fan calling Lash Legend a Naomi Knockoff-Malakai Black clarifies AEW status while tackling being sent death threats-LOADS MORE!!!===SUPPORT OUR SPONSORS BELOW AS THEY SUPPORT THIS SHOW===KORRUPTIONSTUDIOS.COM VIA https://korruptionstudios.com/FOR THE LATEST IN ENTERTAINMENT, LIFE, FASHION, AND CULTURE WITHOUT ALL THE SPYWARE AND ANOYING POPUPS, CHECK OUT KORRUPTIONS STUDIOS WEBSITE! ANIME, SCIENCE, MOVIES, AND SO SO MUCH MORE!BROUGHT TO YOU IN PART BY NY WEIGHT LOSS MD VIAhttps://www.nyweightlossmd.com/Do you struggle to Lose weight or do you lose weight only to gain it back again? Have you tried numerous diets and exercise plans unsuccessfully? We know how it's challenging to maintain and lose weight. You are not alone. NY Weight loss MD program is designed to get you results you want in a safe and effective way. The Weight Loss MD program is virtual/online, that's doctor supervised serving all NY residents. No need to leave your home or endure long wait times to see the doctor. Schedule a free online consultation to find out how we can help you.BROUGHT TO YOU IN PART BY TRAVEL AGENT SPECIALIST LE ANDRA BRATTON VIA https://evotravelagent.com/leandra NEED HELP BOOKING FLIGHTS, HOTELS, CRUISES, TOURS, SCORING SOME SWEET SPORT EVENT TICKETS, OR RENTING A CAR? IF YOU'RE ALWAYS ON THE GO AND DON'T REALLY HAVE THE TIME OR ENERGY OR MAYBE YOU NEED SOMEONE THAT'S VERY RESOURCEFUL AND WELL CONNECTED TO DO THE LEGWORK FOR YOU, YOU'VE GOTTA HIT UP MY LE ANDRA! SHE WILL DO HER BEST TO FIND YOU THE BEST DEALS THAT'S OUT THERE WHILE MAKING SURE THE OVERALL EXPERIENCE YOU HAVE WHEREEVER YOU FIND YOURSELF TRAVELING IS A GOOD ONE! ALL WHILE PROVIDING PERSONAL RECCOMMENDATIONS, AND GREAT ATTENTION TO DETAIL! VISIT HER SITE OR GIVE HER A CALL AT 951-525-6010.FOR THE BEST HOSTING SOLUTIONS FOR INDIVIDUALS AND BUSINESSES VISIT ARKHOST.ORG OR ARK.HOST VIA https://arkhost.org/ARKHOST, MOVING AT THE SPEED OF THE WEB! ARKHOST OFFERS SHARED HOSTING, DOMAIN NAMES, VIRTUAL PRIVATE SERVERS, BUSINESS EMAIL HOSTING, WEBSITE SECURITY SOLUTIONS WITH MANY MORE ADDONS AND OPTIONS. ARKHOST FOCUS IS TO PROVIDE YOU THE BEST PERFORMANCE, PLUS AN EASY TO-MANAGE SYSTEM. YOU CAN ALWAYS RELY ON THEIR STATE-OF-THE-ART ENVIRONMENT-FRIENDLY INFRASTUREBROUGHT TO YOU IN PART BY HEALTHYSPIN1.COM VIA https://healthyspin1.com/IF YOU'RE IN NEED OF THE BEST HEALTHY AND DELICIOUS GUMMY VITAMINS WITHOUT THAT NASTY AFTERTASTE AND MADE WITH GREAT QUALITY, YOU'VE GOTTA CHECK OUT HEALTHYSPIN1.COM AND USE PROMO CODE SANDERS15 TO SAVE 15% OFF YOUR ORDER!BROUGHT TO YOU IN PART BY EXPODIGITALS.COM VIA https://www.expodigitals.com/YOUR SOURCE FOR ACCESSING HUNDRES OF DIGITAL PRODUCTS! GET ACCESS TO THEIR ENTIRE LIBRARY OF VIDEO COURSES AND MATERIALS!! WANT TO LEARN ABOUT BOOSTING YOUR IMMUNE SYSTEM? UNDERSTANDING INSTAGRAM OR OTHER PLATFORMS? BOOSTING YOUR ONLINE SALES FOR YOUR ECOMMERCE STORE?EATING HEALTHIER OR WORKING OUT? YOU CAN FIND THAT AND MORE AT EXPODIGITALS.COM YOUR ELEARNING ONLINE MARKETPLACE WHERE YOU CAN PAY ONE LIFETIME FEE TO ACCESS HUNDREDS OF CONTENT, COURSES, AND EBOOKS!BROUGHT TO YOU IN PART BY https://www.cheapsoftwarelicenses.co.ukNeed Microsoft office but can't afford the yearly subscription of £80? Don't worry! Here at Cheap Software Licenses LTD, we will give you a LIFETIME license for only £60! No need to ever renew your license again! If your computer running too slow, outdated or can't play the games your friends are playing with? Show off with the latest high end models at half the retail price! Alienware laptops from only £800! That's 64gb ram, 1tb SSD storage and NVIDIA GeForce RTX 2080! Incredible savings!BROUGHT TO YOU IN PART BY GIVECBDTHANKS.COM VIA https://givecbdthanks.com/IF YOU NEED CBD PRODUCTS FULL OF GREAT QUALITY AND SATISFICATION GUARENTEED, HEAD OVER TO GIVECBDTHANKS.COM GIVECBDTHANKS.COM OFFERS 100% ALL NATURAL CBD OIL AND MOSTLY ORGANIC INGREDIENTS WITH NO PRESERVATIVES! FROM LOLIPOPS, GUMMIES, SHATTERS, GIVECBDTHANKS.COM OFFERS GREAT VARIETY!BROUGHT TO YOU IN PART BY ESHOPONLINEUSA.COM VIA https://www.eshoponlineusa.com/ESHOPONLINEUSA.COM IS YOUR ULTIMATE DESTINATION FOR ALL THINGS MALE ENHANCEMENT SUPPLEMENTS. GET THAT LION ROARING AGAIN AS THEY OFFER SUPPLEMENTS FOR MEN, EVEN SPRAYS, RHINO PILLS, EVEN PRODUCTS FOR HER! ESHOPONLINEUSA.COMBROUGHT TO YOU IN PART BY CORECHAIR.COMTHE CORECHAIR IS GREAT FOR OPTIMIZED SITTING POSTURE. CORECHAIR IS THE ONLY OFFICE CHAIR ON THE MARKET THAT TACKLES SLUMPING, STIMULATES MUSCLES AND SO MUCH MORE! GET A A 60-DAY TRIAL NOW TO TEST OUT THEIR CHAIRS.ALSO BROUGHT TO YOU IN PART BY MYLASTINGWISH.COMLOOKING TO CREAT YOUR OWN WILL THAT'LL DOCUMENT YOUR WANTS AND WISHES? OR MAYBE WANTING TO LEAVE A MESSAGE OR VIDEO WITH FAMILY AND FRIENDS ONCE YOU'RE GONE? MYLASTINGWISH.COM CAN HELP!BROUGHT TO YOU IN PART BY THISDAYINWINEHISTORY.COMThis Day in Wine History is for history and wine lovers alike. If you enjoy pairing world-class wine with award-winning documentaries, then this site is for you! Our articles are broken into DAYS (this day in wine history for all 365 days!), ARTICLES, and IN-DEPTH, which focus on deeper research, academic citations, and longer essays return here for the true history lover!SUPPORT THE SHOW FOR EVEN MORE GREAT, NEW, AND EXCLUSIVE CONTENT! PATREON: patreon.com/rcwrshow​​​​DISCORD CHANNEL: https://rebrand.ly/rcwrshowdiscordLISTEN THE RCWR SHOW ON THE FOLLOWING PLATFORMS:AMAZON MUSIC & AUDIBLE! https://rebrand.ly/jdt4b9vITUNES: https://rb.gy/rsax57PANDORA! https://rb.gy/3v3oc8iHEARTRADIO: https://rb.gy/j0isjnSTITCHER: https://rebrand.ly/rcwrshowstitcherTUNE IN: https://rebrand.ly/fgxyotx===========================FOLLOW THE RCWR SHOW ALL THROUGHOUT SOCIAL MEDIA!!!http://www.twitter.com/TheRCWRshowhttp://www.Twitch.tv/RCWRshowhttp://www.YouTube.com/THERCWRSHOWhttp://www.instagram.com/THERCWRSHOWhttp://www.facebook.com/THERCWRSHOW===========================

KNX In Depth
KNX In Depth: Hurricane Ian devastates Florida--January 6th Committee and Ginni Thomas--Tips to deal with soaring gas prices--High School girls flag football--Rocky Horror Picture Show goes on tour

KNX In Depth

Play Episode Listen Later Sep 29, 2022 47:58


Death and destruction. Hurricane Ian has ripped through Florida leaving behind immense damage. There are reports that at least 15 people have been confirmed killed across the state but officials say that number could grow much higher as rescue crews wade through massive floodwaters from Fort Myers to Orlando and Daytona Beach. We go In Depth into one of the worst hurricanes to ever hit Florida.  Gas prices here at home are skyrocketing. We're going to help you figure out the best ways to deal with them.  The wife of Supreme Court Justice Clarence Thomas has talked to the January 6th Committee. Ginni Thomas answered questions for a while. We go In Depth into what she told them.  Russia is formally taking land away from Ukraine but will anyone other than Russia acknowledge it?  Girls football is set to become the newest high school sport next year in southern California. This as more and more girls are playing the sport.  The Rocky Horror Picture Show is a cult classic. It's going on tour now. We look into why it's still so popular.   To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

The Ben and Ashley I Almost Famous Podcast
Almost Famous In Depth: Genevieve Parisi

The Ben and Ashley I Almost Famous Podcast

Play Episode Listen Later Sep 29, 2022 22:15


Fresh from the sand in Paradise, Genevieve Parisi sits down with Ben to go IN DEPTH about her experience on The Bachelor and what really happened down on BIP. Genevieve gets real about what it's like in Paradise because she completely disagrees with Ashley about how much “fun” it is to film the show.   Discover the less than glamorous situation that might lead to a lifetime relationship… or at least a sleepover with some tropical raccoons.See omnystudio.com/listener for privacy information.

KNX In Depth
KNX In Depth: Hurricane Ian lashes Florida--Katie Couric breast cancer treatment--Alzheimer's drug shows promise--Bill O'Reilly talks politics, midterm elections and his new book

KNX In Depth

Play Episode Listen Later Sep 28, 2022 50:49


Hurricane Ian finally slams into Florida. It's now smashing into the southwest part of the state in the Fort Myers area as a Category 4 storm with winds of about 150 miles an hour. There's already been power outages, flooding and storm surges in the region. We go In Depth into what damage it might do to Florida.  A couple million people have been told to evacuate but some people are staying home to weather this colossal storm. We talk to a relative of mine who's doing just that in the Tampa area.   Russia is trying to keep people from leaving the country while the U.S. is trying to get its own citizens out. We look into why.  Katie Couric announced she's been treated for breast cancer but it may have been caught earlier if not for the pandemic.  A new study shows some promise for a new drug to treat Alzheimer's Disease. We go In Depth into what it shows and when it might be available for people.  Bill O'Reilly joins us. The former Fox News host will share his thoughts on what's happening in Washington D.C. and discuss his new book about the deaths of three major celebrities.  To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

The RCWR Show with Lee Sanders
Episode 970-Edge Returns! White Rabbit Strikes Again! The RCWR Show 9/26/22

The RCWR Show with Lee Sanders

Play Episode Listen Later Sep 28, 2022 95:57


411MANIA.COM reporter & columnist Lee Sanders is back with his WWE RAW September 26th 2022 recap and review as we get our latest White Rabbit clue, AJ Styles being stalked by Judgement Day, latest in headlines and more in action!!!===SUPPORT OUR SPONSORS BELOW AS THEY SUPPORT THIS SHOW===KORRUPTIONSTUDIOS.COM VIA https://korruptionstudios.com/FOR THE LATEST IN ENTERTAINMENT, LIFE, FASHION, AND CULTURE WITHOUT ALL THE SPYWARE AND ANOYING POPUPS, CHECK OUT KORRUPTIONS STUDIOS WEBSITE! ANIME, SCIENCE, MOVIES, AND SO SO MUCH MORE!BROUGHT TO YOU IN PART BY NY WEIGHT LOSS MD VIAhttps://www.nyweightlossmd.com/Do you struggle to Lose weight or do you lose weight only to gain it back again? Have you tried numerous diets and exercise plans unsuccessfully? We know how it's challenging to maintain and lose weight. You are not alone. NY Weight loss MD program is designed to get you results you want in a safe and effective way. The Weight Loss MD program is virtual/online, that's doctor supervised serving all NY residents. No need to leave your home or endure long wait times to see the doctor. Schedule a free online consultation to find out how we can help you.BROUGHT TO YOU IN PART BY TRAVEL AGENT SPECIALIST LE ANDRA BRATTON VIA https://evotravelagent.com/leandra NEED HELP BOOKING FLIGHTS, HOTELS, CRUISES, TOURS, SCORING SOME SWEET SPORT EVENT TICKETS, OR RENTING A CAR? IF YOU'RE ALWAYS ON THE GO AND DON'T REALLY HAVE THE TIME OR ENERGY OR MAYBE YOU NEED SOMEONE THAT'S VERY RESOURCEFUL AND WELL CONNECTED TO DO THE LEGWORK FOR YOU, YOU'VE GOTTA HIT UP MY LE ANDRA! SHE WILL DO HER BEST TO FIND YOU THE BEST DEALS THAT'S OUT THERE WHILE MAKING SURE THE OVERALL EXPERIENCE YOU HAVE WHEREEVER YOU FIND YOURSELF TRAVELING IS A GOOD ONE! ALL WHILE PROVIDING PERSONAL RECCOMMENDATIONS, AND GREAT ATTENTION TO DETAIL! VISIT HER SITE OR GIVE HER A CALL AT 951-525-6010.FOR THE BEST HOSTING SOLUTIONS FOR INDIVIDUALS AND BUSINESSES VISIT ARKHOST.ORG OR ARK.HOST VIA https://arkhost.org/ARKHOST, MOVING AT THE SPEED OF THE WEB! ARKHOST OFFERS SHARED HOSTING, DOMAIN NAMES, VIRTUAL PRIVATE SERVERS, BUSINESS EMAIL HOSTING, WEBSITE SECURITY SOLUTIONS WITH MANY MORE ADDONS AND OPTIONS. ARKHOST FOCUS IS TO PROVIDE YOU THE BEST PERFORMANCE, PLUS AN EASY TO-MANAGE SYSTEM. YOU CAN ALWAYS RELY ON THEIR STATE-OF-THE-ART ENVIRONMENT-FRIENDLY INFRASTUREBROUGHT TO YOU IN PART BY HEALTHYSPIN1.COM VIA https://healthyspin1.com/IF YOU'RE IN NEED OF THE BEST HEALTHY AND DELICIOUS GUMMY VITAMINS WITHOUT THAT NASTY AFTERTASTE AND MADE WITH GREAT QUALITY, YOU'VE GOTTA CHECK OUT HEALTHYSPIN1.COM AND USE PROMO CODE SANDERS15 TO SAVE 15% OFF YOUR ORDER!BROUGHT TO YOU IN PART BY EXPODIGITALS.COM VIA https://www.expodigitals.com/YOUR SOURCE FOR ACCESSING HUNDRES OF DIGITAL PRODUCTS! GET ACCESS TO THEIR ENTIRE LIBRARY OF VIDEO COURSES AND MATERIALS!! WANT TO LEARN ABOUT BOOSTING YOUR IMMUNE SYSTEM? UNDERSTANDING INSTAGRAM OR OTHER PLATFORMS? BOOSTING YOUR ONLINE SALES FOR YOUR ECOMMERCE STORE?EATING HEALTHIER OR WORKING OUT? YOU CAN FIND THAT AND MORE AT EXPODIGITALS.COM YOUR ELEARNING ONLINE MARKETPLACE WHERE YOU CAN PAY ONE LIFETIME FEE TO ACCESS HUNDREDS OF CONTENT, COURSES, AND EBOOKS!BROUGHT TO YOU IN PART BY https://www.cheapsoftwarelicenses.co.ukNeed Microsoft office but can't afford the yearly subscription of £80? Don't worry! Here at Cheap Software Licenses LTD, we will give you a LIFETIME license for only £60! No need to ever renew your license again! If your computer running too slow, outdated or can't play the games your friends are playing with? Show off with the latest high end models at half the retail price! Alienware laptops from only £800! That's 64gb ram, 1tb SSD storage and NVIDIA GeForce RTX 2080! Incredible savings!BROUGHT TO YOU IN PART BY GIVECBDTHANKS.COM VIA https://givecbdthanks.com/IF YOU NEED CBD PRODUCTS FULL OF GREAT QUALITY AND SATISFICATION GUARENTEED, HEAD OVER TO GIVECBDTHANKS.COM GIVECBDTHANKS.COM OFFERS 100% ALL NATURAL CBD OIL AND MOSTLY ORGANIC INGREDIENTS WITH NO PRESERVATIVES! FROM LOLIPOPS, GUMMIES, SHATTERS, GIVECBDTHANKS.COM OFFERS GREAT VARIETY!BROUGHT TO YOU IN PART BY ESHOPONLINEUSA.COM VIA https://www.eshoponlineusa.com/ESHOPONLINEUSA.COM IS YOUR ULTIMATE DESTINATION FOR ALL THINGS MALE ENHANCEMENT SUPPLEMENTS. GET THAT LION ROARING AGAIN AS THEY OFFER SUPPLEMENTS FOR MEN, EVEN SPRAYS, RHINO PILLS, EVEN PRODUCTS FOR HER! ESHOPONLINEUSA.COMBROUGHT TO YOU IN PART BY CORECHAIR.COMTHE CORECHAIR IS GREAT FOR OPTIMIZED SITTING POSTURE. CORECHAIR IS THE ONLY OFFICE CHAIR ON THE MARKET THAT TACKLES SLUMPING, STIMULATES MUSCLES AND SO MUCH MORE! GET A A 60-DAY TRIAL NOW TO TEST OUT THEIR CHAIRS.ALSO BROUGHT TO YOU IN PART BY MYLASTINGWISH.COMLOOKING TO CREAT YOUR OWN WILL THAT'LL DOCUMENT YOUR WANTS AND WISHES? OR MAYBE WANTING TO LEAVE A MESSAGE OR VIDEO WITH FAMILY AND FRIENDS ONCE YOU'RE GONE? MYLASTINGWISH.COM CAN HELP!BROUGHT TO YOU IN PART BY THISDAYINWINEHISTORY.COMThis Day in Wine History is for history and wine lovers alike. If you enjoy pairing world-class wine with award-winning documentaries, then this site is for you! Our articles are broken into DAYS (this day in wine history for all 365 days!), ARTICLES, and IN-DEPTH, which focus on deeper research, academic citations, and longer essays return here for the true history lover!SUPPORT THE SHOW FOR EVEN MORE GREAT, NEW, AND EXCLUSIVE CONTENT! PATREON: patreon.com/rcwrshow​​​​DISCORD CHANNEL: https://rebrand.ly/rcwrshowdiscordLISTEN THE RCWR SHOW ON THE FOLLOWING PLATFORMS:AMAZON MUSIC & AUDIBLE! https://rebrand.ly/jdt4b9vITUNES: https://rb.gy/rsax57PANDORA! https://rb.gy/3v3oc8iHEARTRADIO: https://rb.gy/j0isjnSTITCHER: https://rebrand.ly/rcwrshowstitcherTUNE IN: https://rebrand.ly/fgxyotx===========================FOLLOW THE RCWR SHOW ALL THROUGHOUT SOCIAL MEDIA!!!http://www.twitter.com/TheRCWRshowhttp://www.Twitch.tv/RCWRshowhttp://www.YouTube.com/THERCWRSHOWhttp://www.instagram.com/THERCWRSHOWhttp://www.facebook.com/THERCWRSHOW===========================

The Ben and Ashley I Almost Famous Podcast
Almost Famous In Depth: Victoria Fuller

The Ben and Ashley I Almost Famous Podcast

Play Episode Listen Later Sep 27, 2022 12:27 Very Popular


Ben in Las Vegas with Victoria Fuller from Peter Weber's season! We're sitting down with Victoria and going IN DEPTH to know her beyond what you saw on The Bachelor.   We hear all about her experience in Paradise and she spills everything about WHO she wanted to meet on the beach.   Plus, she shares who caused the most drama on this upcoming season of Paradise!  See omnystudio.com/listener for privacy information.

KNX In Depth
KNX In Depth: Hurricane Ian approaches Florida--Karen Bass and Scientology--NASA's DART hits asteroid--Debt piling up for Americans--Hot Girl Walk

KNX In Depth

Play Episode Listen Later Sep 27, 2022 45:47


More than 2.5 million people in Florida are packing up and heading away from the state's west coast as they've been told to evacuate ahead of incoming Hurricane Ian. It just tore into western Cuba as a Category 3 storm and has left one million people without electricity. We go In Depth into what to expect when Ian slams Florida.  The latest attack ad in the LA mayor's race tries to link Karen Bass to Scientology. We look into whether it's working.   NASA's DART spacecraft hits its target. Now we look into whether the plan to save humanity can work.  Debt is piling up for people unless you're rich. We go In Depth into how long people can keep putting things on their credit cards.  The Federal Reserve's plan to help the American economy could be ruining economies across the world.  Doctors and other medical experts are wondering if this is the calm before another Winter COVID storm.  Social media sparks lots of trends and crazes. The latest one is the Hot Girl Walk. We explain what that is.  To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

Saying it outloud!
EP 66: Excuses

Saying it outloud!

Play Episode Listen Later Sep 27, 2022 34:58


We talk about some of the most common excuses we get and our biggest excuse when it came to fitness. Then we touch on how excuses set you back. Lastly, we rant about people putting their health on the back burner because they are afraid to invest in it.Follow us on social media:   @Leos_fitness_adventure   @Stephmoralessfit  Join our free Facebook group where go Indepth on all kinds of topics:  https://m.facebook.com/groups/804195770472212/?ref=group_browse   Buy the latest fitness apparel:Valhalla-Athletics (valhalla-athleticsapparel.com)   Apply for 1:1 coaching and get the results you are looking for:  https://www.valhalla-athletics.com  Don't forget to like, share, comment, and leave a 5-star review if you learned something new.

Dean Delray's LET THERE BE TALK
#666 : King Diamond / Mercyful Fate

Dean Delray's LET THERE BE TALK

Play Episode Listen Later Sep 26, 2022 143:50 Very Popular


Episode 666 is here and what better guest to have than the legend himself King Diamond of Mercyful Fate. King and I sat down today for a long In-Depth conversation on all things King Diamond including, Influences, Songwriting, Lyrics, Mercyful Fate and even some Car Talk. Mercyful Fate and King Diamond have been a massive influence to the metal world and it was an Honor to sit down with the King. I hope you all enjoy this episode. Brought to you by Better Help. If you want online therapy Better Help is the spot. Hit the link for a Delraiser deal. https://www.betterhelp.com/delray  

In Depth
IN DEPTH: Deidre DeJear, Candidate for Governor

In Depth

Play Episode Listen Later Sep 26, 2022 17:08


A candidate for Governor paid a visit recently. Join us today as Dr. Bob Leonard goes “In Depth” with Democrat Deidre DeJear.

ChirpCast Podcast
In Depth with Ball State (Football Week 4 @ Georgia Southern)

ChirpCast Podcast

Play Episode Listen Later Sep 26, 2022 2:35


In Depth with Ball State is a weekly preview of Ball State Football's next opponent.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

KNX In Depth
KNX In Depth: Hurricane Ian eyes Florida--Governor Newsom vetoes mandatory kindergarten bill--Are long ranges for electric cars worth it?--James Earl Jones steps down as voice of Darth Vader

KNX In Depth

Play Episode Listen Later Sep 26, 2022 51:48


Hurricane Ian is slowly creeping up toward Florida and could pack a massive punch. It might hit the Tampa area as a Category 4 storm as early as Wednesday. Hundreds of thousands of people could face mandatory evacuation orders. Officials are already saying if you're told to leave and don't--they won't come save you. We go In Depth into what to expect from Ian.  The January 6th Committee is back in action this week. We look into whether Governor Newsom had a good reason to veto a bill to make kindergarten mandatory in California.  A study conducted by LinkedIn is being criticized because it may have cost people job opportunities without them really knowing it.  A new survey shows people want EVs with long ranges but is it practical for car makers to do that?  Italy is getting its first far-right government since the second World War. We go In Depth into what could happen there and how it could effect the rest of Europe and the U.S.  You know the voice--Darth Vader. You know the man behind it--James Earl Jones. He says he's done. Who will replace him? It'll be himself--in a way.  To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

nowyouknow's podcast
Teslabot Will Take Your Job | In Depth

nowyouknow's podcast

Play Episode Listen Later Sep 23, 2022 26:45 Very Popular


Get Surfshark VPN at https://www.surfshark.deals/NYK and enter promo code NYK for 83% discount and 3 extra months for free!  To enter for a chance to win a Tesla Model S Plaid go to https://www.speroworldwide.org/ Your odds have never been better! To get the 100 pk of blades for free, make sure to add it to your shopping cart, and use the code 'nowyouknow'. Thanks again to Henson Shaving for sponsoring this episode of In Depth! https://bit.ly/3CMf5Mq Now You Know Clips Channel: https://www.youtube.com/channel/UCacwzDEdpVEO2UjIO00CpqQ Disruptive Investing Channel: https://www.youtube.com/channel/UCTuFDdZdVXgfeZAxTubID0g   Find the shirts that Zac & Jesse are wearing over at Ecowear: https://nowyouknow.ecowear.us/ Use promo code “NowYouKnow” to get your free trial of A Better Route Planner Premium. https://abetterrouteplanner.com/ref/NOWYOUKNOW Check out our Now You Know Clips channel here! https://www.youtube.com/channel/UCacwzDEdpVEO2UjIO00CpqQ Check out Energy Pals here: https://energypal.com/nowyouknow/ Patreon: https://www.patreon.com/nowyouknow

The RCWR Show with Lee Sanders
Episode 969-Sarya Knight aka Paige is ALL ELITE! Three's a Charm! The RCWR Show 9/21/22

The RCWR Show with Lee Sanders

Play Episode Listen Later Sep 23, 2022 106:35


411MANIA.COM reporter & columnist Lee Sanders is back to cover AEW Dynamite 9/21/22 Grandslam fallout as a new AEW World Champion is crowned from Jon Moxley vs Bryan Danielson! Get the lowdown from the show along with the latest in headlines and beyond!===SUPPORT OUR SPONSORS BELOW AS THEY SUPPORT THIS SHOW===BROUGHT TO YOU IN PART BY MYBUBBLESLIPPER.COM VIA https://mybubbleslipper.com/OFFERING FREE SHIPPING AND HASSLE FREE EXCHANGES IF YOU'RE NOT COMPLETLY SATISFIED WITH YOUR SELECTION! RIGHT NOW AT MYBUBBLESLIPPER.COM IS THEIR SHARK DESIGN SLIPPERS AVAILABLE FOR JUST $23! ACT NOW AS THIS ITEM IS SELLING FAST AND IS AVAILABLE ONLY FOR A LIMITED TIME! MYBUBBLESLIPPER.COMKORRUPTIONSTUDIOS.COM VIA https://korruptionstudios.com/FOR THE LATEST IN ENTERTAINMENT, LIFE, FASHION, AND CULTURE WITHOUT ALL THE SPYWARE AND ANOYING POPUPS, CHECK OUT KORRUPTIONS STUDIOS WEBSITE! ANIME, SCIENCE, MOVIES, AND SO SO MUCH MORE! BROUGHT TO YOU IN PART BY NY WEIGHT LOSS MD VIA https://www.nyweightlossmd.com/Do you struggle to Lose weight or do you lose weight only to gain it back again? Have you tried numerous diets and exercise plans unsuccessfully? We know how it's challenging to maintain and lose weight. You are not alone. NY Weight loss MD program is designed to get you results you want in a safe and effective way. The Weight Loss MD program is virtual/online, that's doctor supervised serving all NY residents. No need to leave your home or endure long wait times to see the doctor. Schedule a free online consultation to find out how we can help you.BROUGHT TO YOU IN PART BY TRAVEL AGENT SPECIALIST LE ANDRA BRATTON VIA https://evotravelagent.com/leandra NEED HELP BOOKING FLIGHTS, HOTELS, CRUISES, TOURS, SCORING SOME SWEET SPORT EVENT TICKETS, OR RENTING A CAR? IF YOU'RE ALWAYS ON THE GO AND DON'T REALLY HAVE THE TIME OR ENERGY OR MAYBE YOU NEED SOMEONE THAT'S VERY RESOURCEFUL AND WELL CONNECTED TO DO THE LEGWORK FOR YOU, YOU'VE GOTTA HIT UP MY LE ANDRA! SHE WILL DO HER BEST TO FIND YOU THE BEST DEALS THAT'S OUT THERE WHILE MAKING SURE THE OVERALL EXPERIENCE YOU HAVE WHEREEVER YOU FIND YOURSELF TRAVELING IS A GOOD ONE! ALL WHILE PROVIDING PERSONAL RECCOMMENDATIONS, AND GREAT ATTENTION TO DETAIL! VISIT HER SITE OR GIVE HER A CALL AT 951-525-6010.FOR THE BEST HOSTING SOLUTIONS FOR INDIVIDUALS AND BUSINESSES VISIT ARKHOST.ORG OR ARK.HOST VIA https://arkhost.org/ARKHOST, MOVING AT THE SPEED OF THE WEB! ARKHOST OFFERS SHARED HOSTING, DOMAIN NAMES, VIRTUAL PRIVATE SERVERS, BUSINESS EMAIL HOSTING, WEBSITE SECURITY SOLUTIONS WITH MANY MORE ADDONS AND OPTIONS. ARKHOST FOCUS IS TO PROVIDE YOU THE BEST PERFORMANCE, PLUS AN EASY TO-MANAGE SYSTEM. YOU CAN ALWAYS RELY ON THEIR STATE-OF-THE-ART ENVIRONMENT-FRIENDLY INFRASTUREBROUGHT TO YOU IN PART BY HEALTHYSPIN1.COM VIA https://healthyspin1.com/IF YOU'RE IN NEED OF THE BEST HEALTHY AND DELICIOUS GUMMY VITAMINS WITHOUT THAT NASTY AFTERTASTE AND MADE WITH GREAT QUALITY, YOU'VE GOTTA CHECK OUT HEALTHYSPIN1.COM AND USE PROMO CODE SANDERS15 TO SAVE 15% OFF YOUR ORDER!BROUGHT TO YOU IN PART BY EXPODIGITALS.COM VIA https://www.expodigitals.com/YOUR SOURCE FOR ACCESSING HUNDRES OF DIGITAL PRODUCTS! GET ACCESS TO THEIR ENTIRE LIBRARY OF VIDEO COURSES AND MATERIALS!! WANT TO LEARN ABOUT BOOSTING YOUR IMMUNE SYSTEM? UNDERSTANDING INSTAGRAM OR OTHER PLATFORMS? BOOSTING YOUR ONLINE SALES FOR YOUR ECOMMERCE STORE?EATING HEALTHIER OR WORKING OUT? YOU CAN FIND THAT AND MORE AT EXPODIGITALS.COM YOUR ELEARNING ONLINE MARKETPLACE WHERE YOU CAN PAY ONE LIFETIME FEE TO ACCESS HUNDREDS OF CONTENT, COURSES, AND EBOOKS!BROUGHT TO YOU IN PART BY https://www.cheapsoftwarelicenses.co.ukNeed Microsoft office but can't afford the yearly subscription of £80? Don't worry! Here at Cheap Software Licenses LTD, we will give you a LIFETIME license for only £60! No need to ever renew your license again! If your computer running too slow, outdated or can't play the games your friends are playing with? Show off with the latest high end models at half the retail price! Alienware laptops from only £800! That's 64gb ram, 1tb SSD storage and NVIDIA GeForce RTX 2080! Incredible savings!BROUGHT TO YOU IN PART BY GIVECBDTHANKS.COM VIA https://givecbdthanks.com/IF YOU NEED CBD PRODUCTS FULL OF GREAT QUALITY AND SATISFICATION GUARENTEED, HEAD OVER TO GIVECBDTHANKS.COM GIVECBDTHANKS.COM OFFERS 100% ALL NATURAL CBD OIL AND MOSTLY ORGANIC INGREDIENTS WITH NO PRESERVATIVES! FROM LOLIPOPS, GUMMIES, SHATTERS, GIVECBDTHANKS.COM OFFERS GREAT VARIETY!BROUGHT TO YOU IN PART BY ESHOPONLINEUSA.COM VIA https://www.eshoponlineusa.com/ESHOPONLINEUSA.COM IS YOUR ULTIMATE DESTINATION FOR ALL THINGS MALE ENHANCEMENT SUPPLEMENTS. GET THAT LION ROARING AGAIN AS THEY OFFER SUPPLEMENTS FOR MEN, EVEN SPRAYS, RHINO PILLS, EVEN PRODUCTS FOR HER! ESHOPONLINEUSA.COMBROUGHT TO YOU IN PART BY CORECHAIR.COMTHE CORECHAIR IS GREAT FOR OPTIMIZED SITTING POSTURE. CORECHAIR IS THE ONLY OFFICE CHAIR ON THE MARKET THAT TACKLES SLUMPING, STIMULATES MUSCLES AND SO MUCH MORE! GET A A 60-DAY TRIAL NOW TO TEST OUT THEIR CHAIRS.ALSO BROUGHT TO YOU IN PART BY MYLASTINGWISH.COMLOOKING TO CREAT YOUR OWN WILL THAT'LL DOCUMENT YOUR WANTS AND WISHES? OR MAYBE WANTING TO LEAVE A MESSAGE OR VIDEO WITH FAMILY AND FRIENDS ONCE YOU'RE GONE? MYLASTINGWISH.COM CAN HELP!BROUGHT TO YOU IN PART BY THISDAYINWINEHISTORY.COMThis Day in Wine History is for history and wine lovers alike. If you enjoy pairing world-class wine with award-winning documentaries, then this site is for you! Our articles are broken into DAYS (this day in wine history for all 365 days!), ARTICLES, and IN-DEPTH, which focus on deeper research, academic citations, and longer essays return here for the true history lover!SUPPORT THE SHOW FOR EVEN MORE GREAT, NEW, AND EXCLUSIVE CONTENT! PATREON: patreon.com/rcwrshow​​​​DISCORD CHANNEL: https://rebrand.ly/rcwrshowdiscordLISTEN THE RCWR SHOW ON THE FOLLOWING PLATFORMS:AMAZON MUSIC & AUDIBLE! https://rebrand.ly/jdt4b9vITUNES: https://rb.gy/rsax57PANDORA! https://rb.gy/3v3oc8iHEARTRADIO: https://rb.gy/j0isjnSTITCHER: https://rebrand.ly/rcwrshowstitcherTUNE IN: https://rebrand.ly/fgxyotx===========================FOLLOW THE RCWR SHOW ALL THROUGHOUT SOCIAL MEDIA!!!http://www.twitter.com/TheRCWRshowhttp://www.Twitch.tv/RCWRshowhttp://www.YouTube.com/THERCWRSHOWhttp://www.instagram.com/THERCWRSHOWhttp://www.facebook.com/THERCWRSHOW===========================

In Depth
IN DEPTH: The Well Wheels Program

In Depth

Play Episode Listen Later Sep 23, 2022 14:55


Do you have an old car that you would like to put to good use? Considering donating it to the Well Wheels program. Join us today as Dr. Bob Leonard goes “In Depth” with Eden Koolmees with

KNX In Depth
KNX In Depth: Brutal week for Wall Street--LA County ends mask mandate on public transit--NASA spacecraft to slam into asteroid--Fetuses like and don't like certain foods

KNX In Depth

Play Episode Listen Later Sep 23, 2022 49:30


The Dow is down big today in a brutal week that ravaged the stock market. It's now on track to close the week 1,000 points below where it started. This comes after the Federal Reserve raised interest rates. We go In Depth into whether we're moving full speed toward a recession.  NASA is smashing a spacecraft into an asteroid, and it if works, it could save human civilization.  Hurricane Fiona is far from done wreaking havoc. It's about to smash into Canada in what could be one of the worst storms to ever hit the country.  LA County is easing its mask requirements again. You can take them off now on public transit and at airports. But how long will that last and is the county using the right metrics? We go In Depth.  Russia is holding a vote in occupied areas of Ukraine to let people decide if they want to join Russia. We head to Ukraine where many are calling it a "sham." Living in a nursing home and other assisted-living facilities is getting more expensive for seniors.  And fetuses can't taste food, can they? New research hints at why kids might not like certain foods.  To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

Bibles, Babies, & Business - Christian Entrepreneur, Stay at Home Mom, Coaching Business, Making Money Online, Marketing and
78 \\ 5 Practical Ways to Overcome Laziness & Develop a Disciplined Morning Routine as a Christian Mom Entrepreneur. Bible Study Breakdown | Proverbs

Bibles, Babies, & Business - Christian Entrepreneur, Stay at Home Mom, Coaching Business, Making Money Online, Marketing and

Play Episode Listen Later Sep 22, 2022 28:22


If there was one book of the Bible that is most relevant to the Christian entrepreneur, it would be Proverbs. & one of the biggest threats coming against the success of online coaches is… the spirit of laziness. Which is discussed IN DEPTH inside the book of Proverbs. Today's episode is going to probably sting a little… Instead of shying away from that, I challenge you to embrace it. We're all being refined together, friend! Here's the thing though… being refined doesn't feel good... “No discipline is enjoyable while it is happening - it's painful! But afterward there will be a peaceful harvest of right living for those who are trained in it's way.” ~ Hebrews 12:11 Isn't it interesting how the most disciplined business owners also tend to be the most financially successful business owners? That's not a coincidence… So today we're going to tackle laziness head on, TOGETHER! Here are 5 practical ways to overcome laziness & develop a disciplined morning routine as a Christian Mom Entrepreneur. Grab your Bibles & let's do this! Xoxo, Camie

KNX In Depth
KNX In Depth: LA mayor's race heats up with first debate--LAUSD to tackle drug overdoses--STDs on the rise--Famous historical interracial friendships and lessons for today's divided political climate

KNX In Depth

Play Episode Listen Later Sep 22, 2022 49:14


We have more questions than answers now that Karen Bass and Rick Caruso have debated for the first time. They tried to skirt around some questions about conflicts of interest and a potential scandal. We go In Depth into whether we all really learned more about what each candidate stands for and if either one stood out.  The LA School District plans to do something about a recent rash of teenage drug overdoses. We look into whether schools can actually help.  Russia and Iran have hardline governments but current protests show those governments might not be as powerful as they project.  Former President Trump says the president can declassify documents just by saying or thinking about it. We go In Depth to clear that up.  STDs are on the rise nationally. We try to find out what's going on. Friendships could unite us in troubled political times. We talk to a scholar and author about how his new book about famous interracial friendships can heal us today.  To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

Physician's Weekly Podcast
An inDEPTH Look at Chronic Myeloid Leukemia

Physician's Weekly Podcast

Play Episode Listen Later Sep 21, 2022 26:42


To acknowledge the Philadelphia Chromosome translocation t(9;22) in chronic myeloid leukemia (CML), every September 22 (9/22) is World CML Day. Today's podcast episode looks at this topic through different lenses. First, two members of the Lancet Haematology's committee on adverse events—Jan Geissler, co-founder of the CML Advocates Network, and Gita Thanarajasingam, MD, the committee chair and a hematologist at the Mayo Clinic—discuss how side effects are reported and analyzed and how the committee intends to change that. Geissler also talks about how his experience as a patient with CML led him to become and expert advocate. Additional reading:Geissler J, Huber S. Improving outcomes through patient-generated evidence-the next step in patient advocacy. Lancet Haematol. 2022 Jun;9(6):e399-e400. Thanarajasingam G, et al. Reaching beyond maximum grade: progress and future directions for modernising the assessment and reporting of adverse events in haematological malignancies. Lancet Haematol. 2022 May;9(5):e374-e384Basch E, Deal AM, Dueck AC, Scher HI, Kris MG, Hudis C, Schrag D. Overall Survival Results of a Trial Assessing Patient-Reported Outcomes for Symptom Monitoring During Routine Cancer Treatment. JAMA. 2017 Jul 11;318(2):197-198. 

KNX In Depth
KNX In Depth: New York sues former President Trump--LA mayor's race intensifies--Federal Reserve interest rate hike--Ken Burns on his new documentary "The U.S. and the Holocaust"

KNX In Depth

Play Episode Listen Later Sep 21, 2022 50:30


The first of what could possibly be several legal dominoes has fallen on former President Trump. New York Attorney General Letitia James has filed a civil lawsuit against Trump, three of his children and two longtime company executives.  The lawsuit alleges business fraud. We go In Depth into what this means for other cases against Trump moving forward.  Russia is calling up more troops to fight in Ukraine.  More than one million people are still without power in Puerto Rico following Hurricane Fiona.  The LA Mayor's race is kicking into high gear. The first debate between Rick Caruso and Karen Bass is tonight. The Federal Reserve raised interest rates again. We go In Depth into whether it can slow down inflation.  We end the show with filmmaker Ken Burns to talk about his new documentary series The U.S. and the Holocaust and what it means in today's political climate.  To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

In Depth
IN DEPTH: Wowbrary! KNIA and KRLS

In Depth

Play Episode Listen Later Sep 21, 2022 17:09


What's Wowbrary? Join us today as Dr. Bob Leonard goes “In Depth” with Mara Strickler, with the Pella Public Library.

The RCWR Show with Lee Sanders
Episode 968-Roman Reigns Past Foes Unite for WAR GAMES at Survivor Series? The RCWR Show 9/19/22

The RCWR Show with Lee Sanders

Play Episode Listen Later Sep 20, 2022 135:35


411MANIA.COM reporter & columnist Lee Sanders returns to review WWE RAW September 19th 2022 fallout as Lashley vs Seth Rollins, Damage Control faces Bliss, Belair, and Asuka! ===Reminder of loads of great content pumped out over the weekend===Check out Lee, Mish Thomas of WRESTLING SOUP, and Julian Cannon of Digiday.com and THE WRESTLING COURT SUPERSHOW special===Reminder: Check out the new QUANTUM LEAP show===RAW recap===Listener questions===Trish Stratus health scare===Importance of listening to your body===Lee's idea on former foes of Roman Reigns past unite to face him and The Bloodline at WAR GAMES===Malakai Black speaks on stepping away from wrestling, SHINE WRESTLING 74 and Progress Wrestling weekend results===EC3 responds to Velveteen Dream and loads more!!!===SUPPORT OUR SPONSORS BELOW AS THEY SUPPORT THIS SHOW===BROUGHT TO YOU IN PART BY NY WEIGHT LOSS MD VIA https://www.nyweightlossmd.com/Do you struggle to Lose weight or do you lose weight only to gain it back again? Have you tried numerous diets and exercise plans unsuccessfully? We know how it's challenging to maintain and lose weight. You are not alone. NY Weight loss MD program is designed to get you results you want in a safe and effective way. The Weight Loss MD program is virtual/online, that's doctor supervised serving all NY residents. No need to leave your home or endure long wait times to see the doctor. Schedule a free online consultation to find out how we can help you.BROUGHT TO YOU IN PART BY TRAVEL AGENT SPECIALIST LE ANDRA BRATTON VIA https://evotravelagent.com/leandra NEED HELP BOOKING FLIGHTS, HOTELS, CRUISES, TOURS, SCORING SOME SWEET SPORT EVENT TICKETS, OR RENTING A CAR? IF YOU'RE ALWAYS ON THE GO AND DON'T REALLY HAVE THE TIME OR ENERGY OR MAYBE YOU NEED SOMEONE THAT'S VERY RESOURCEFUL AND WELL CONNECTED TO DO THE LEGWORK FOR YOU, YOU'VE GOTTA HIT UP MY LE ANDRA! SHE WILL DO HER BEST TO FIND YOU THE BEST DEALS THAT'S OUT THERE WHILE MAKING SURE THE OVERALL EXPERIENCE YOU HAVE WHEREEVER YOU FIND YOURSELF TRAVELING IS A GOOD ONE! ALL WHILE PROVIDING PERSONAL RECCOMMENDATIONS, AND GREAT ATTENTION TO DETAIL! VISIT HER SITE OR GIVE HER A CALL AT 951-525-6010.FOR THE BEST HOSTING SOLUTIONS FOR INDIVIDUALS AND BUSINESSES VISIT ARKHOST.ORG OR ARK.HOST VIA https://arkhost.org/ARKHOST, MOVING AT THE SPEED OF THE WEB! ARKHOST OFFERS SHARED HOSTING, DOMAIN NAMES, VIRTUAL PRIVATE SERVERS, BUSINESS EMAIL HOSTING, WEBSITE SECURITY SOLUTIONS WITH MANY MORE ADDONS AND OPTIONS. ARKHOST FOCUS IS TO PROVIDE YOU THE BEST PERFORMANCE, PLUS AN EASY TO-MANAGE SYSTEM. YOU CAN ALWAYS RELY ON THEIR STATE-OF-THE-ART ENVIRONMENT-FRIENDLY INFRASTUREBROUGHT TO YOU IN PART BY HEALTHYSPIN1.COM VIA https://healthyspin1.com/IF YOU'RE IN NEED OF THE BEST HEALTHY AND DELICIOUS GUMMY VITAMINS WITHOUT THAT NASTY AFTERTASTE AND MADE WITH GREAT QUALITY, YOU'VE GOTTA CHECK OUT HEALTHYSPIN1.COM AND USE PROMO CODE SANDERS15 TO SAVE 15% OFF YOUR ORDER!BROUGHT TO YOU IN PART BY EXPODIGITALS.COM VIA https://www.expodigitals.com/YOUR SOURCE FOR ACCESSING HUNDRES OF DIGITAL PRODUCTS! GET ACCESS TO THEIR ENTIRE LIBRARY OF VIDEO COURSES AND MATERIALS!! WANT TO LEARN ABOUT BOOSTING YOUR IMMUNE SYSTEM? UNDERSTANDING INSTAGRAM OR OTHER PLATFORMS? BOOSTING YOUR ONLINE SALES FOR YOUR ECOMMERCE STORE?EATING HEALTHIER OR WORKING OUT? YOU CAN FIND THAT AND MORE AT EXPODIGITALS.COM YOUR ELEARNING ONLINE MARKETPLACE WHERE YOU CAN PAY ONE LIFETIME FEE TO ACCESS HUNDREDS OF CONTENT, COURSES, AND EBOOKS!BROUGHT TO YOU IN PART BY https://www.cheapsoftwarelicenses.co.ukNeed Microsoft office but can't afford the yearly subscription of £80? Don't worry! Here at Cheap Software Licenses LTD, we will give you a LIFETIME license for only £60! No need to ever renew your license again! If your computer running too slow, outdated or can't play the games your friends are playing with? Show off with the latest high end models at half the retail price! Alienware laptops from only £800! That's 64gb ram, 1tb SSD storage and NVIDIA GeForce RTX 2080! Incredible savings!BROUGHT TO YOU IN PART BY GIVECBDTHANKS.COM VIA https://givecbdthanks.com/IF YOU NEED CBD PRODUCTS FULL OF GREAT QUALITY AND SATISFICATION GUARENTEED, HEAD OVER TO GIVECBDTHANKS.COM GIVECBDTHANKS.COM OFFERS 100% ALL NATURAL CBD OIL AND MOSTLY ORGANIC INGREDIENTS WITH NO PRESERVATIVES! FROM LOLIPOPS, GUMMIES, SHATTERS, GIVECBDTHANKS.COM OFFERS GREAT VARIETY!BROUGHT TO YOU IN PART BY ESHOPONLINEUSA.COM VIA https://www.eshoponlineusa.com/ESHOPONLINEUSA.COM IS YOUR ULTIMATE DESTINATION FOR ALL THINGS MALE ENHANCEMENT SUPPLEMENTS. GET THAT LION ROARING AGAIN AS THEY OFFER SUPPLEMENTS FOR MEN, EVEN SPRAYS, RHINO PILLS, EVEN PRODUCTS FOR HER! ESHOPONLINEUSA.COMBROUGHT TO YOU IN PART BY CORECHAIR.COMTHE CORECHAIR IS GREAT FOR OPTIMIZED SITTING POSTURE. CORECHAIR IS THE ONLY OFFICE CHAIR ON THE MARKET THAT TACKLES SLUMPING, STIMULATES MUSCLES AND SO MUCH MORE! GET A A 60-DAY TRIAL NOW TO TEST OUT THEIR CHAIRS.ALSO BROUGHT TO YOU IN PART BY MYLASTINGWISH.COMLOOKING TO CREAT YOUR OWN WILL THAT'LL DOCUMENT YOUR WANTS AND WISHES? OR MAYBE WANTING TO LEAVE A MESSAGE OR VIDEO WITH FAMILY AND FRIENDS ONCE YOU'RE GONE? MYLASTINGWISH.COM CAN HELP!BROUGHT TO YOU IN PART BY THISDAYINWINEHISTORY.COMThis Day in Wine History is for history and wine lovers alike. If you enjoy pairing world-class wine with award-winning documentaries, then this site is for you! Our articles are broken into DAYS (this day in wine history for all 365 days!), ARTICLES, and IN-DEPTH, which focus on deeper research, academic citations, and longer essays return here for the true history lover!SUPPORT THE SHOW FOR EVEN MORE GREAT, NEW, AND EXCLUSIVE CONTENT! PATREON: patreon.com/rcwrshow​​​​DISCORD CHANNEL: https://rebrand.ly/rcwrshowdiscordLISTEN THE RCWR SHOW ON THE FOLLOWING PLATFORMS:AMAZON MUSIC & AUDIBLE! https://rebrand.ly/jdt4b9vITUNES: https://rb.gy/rsax57PANDORA! https://rb.gy/3v3oc8iHEARTRADIO: https://rb.gy/j0isjnSTITCHER: https://rebrand.ly/rcwrshowstitcherTUNE IN: https://rebrand.ly/fgxyotx===========================FOLLOW THE RCWR SHOW ALL THROUGHOUT SOCIAL MEDIA!!!http://www.twitter.com/TheRCWRshowhttp://www.Twitch.tv/RCWRshowhttp://www.YouTube.com/THERCWRSHOWhttp://www.instagram.com/THERCWRSHOWhttp://www.facebook.com/THERCWRSHOW===========================

KNX In Depth
KNX In Depth: Anxiety screening for adults--Help arriving in Puerto Rico after Hurricane Fiona--LEDs and light pollution--Human composting law

KNX In Depth

Play Episode Listen Later Sep 20, 2022 49:30


The mental health crisis in the U.S. has now reached the point to where an influential group of medical experts is now recommending all adults under 65 years old get screened for anxiety. The U.S. Preventive Services Task Force made similar recommendations earlier this year to begin anxiety screening in children and teens. We go In Depth into this growing problem.  President Biden apparently won't commit to running for re-election in 2024. If he doesn't, a familiar name to everyone in California probably will.  The Supreme Court may have to decide for good if social media companies can censor political speech.  People in California will have the choice in a few years of becoming compost when they die. We go In Depth into how that works and how it might be better for the environment than cremation.  Aid organizations are now helping people in Puerto Rico after Hurricane Fiona swept through. Many people are still without power.  Your breathing muscles could be key to lowering your blood pressure.  LED lights are being criticized because of the light pollution they cause at night. To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

KNX In Depth
KNX In Depth: Queen Elizabeth's grand funeral--Hurricane Fiona slams into Puerto Rico--California inflation relief checks--Purple tomatoes--Phantom of the Opera to shut down on Broadway

KNX In Depth

Play Episode Listen Later Sep 19, 2022 47:49


A country lays to rest its Queen of 70 years. The UK honored Queen Elizabeth today with a massive state funeral--the first since Winston Churchill. Crowds of people lined the streets of London and around Windsor Castle to pay tribute to the only monarch many of them had ever known. We go In Depth into the funeral of Queen Elizabeth.  President Biden says the COVID pandemic is over but not everyone agrees.  Puerto Rico is hit with another big hurricane that left the whole island without electricity. The damage is being called "catastrophic."  If you're bank account is getting drained by rising prices, some relief is coming soon thanks to the state. But is it enough? We go In Depth.  Pharmacies are running short of a drug to help people with ADHD. A new food item might be coming soon to the produce section---a purple tomato. Yes, purple.  The Phantom of the Opera's famous chandelier will drop on Broadway for the final time in a few months. The popular musical is ending its record-setting run.  To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

In Depth
IN DEPTH: Ag Safety Week

In Depth

Play Episode Listen Later Sep 19, 2022 17:04


It's National Farm Safety and Health Week. Join us today as Dr. Bob Leonard goes “In Depth” with Professor Steven Freeman, an Agricultural Engineer at Iowa State University.

The Grumpy Surfer Podcast
OMBE Surf Coach - Luke Hardacre

The Grumpy Surfer Podcast

Play Episode Listen Later Sep 19, 2022 82:23


Luke Hardacre is part of the OMBE Team, he works behind the scenes as a surf coach and is the host of the OMBE Podcast, In-Depth.  Adz and Luke talk surf technique, line-ups, Adz rubbish surfing and much much more.................

Saying it outloud!
EP 65: How to train while injured

Saying it outloud!

Play Episode Listen Later Sep 19, 2022 37:29


Today we go in depth about why you should train even while injured, depending upon the severity. We also touch on how people get injured and how they remain injured. Lastly, we go over how to avoid injury and why having a proper plan is important.Follow us on social media:   @Leos_fitness_adventure   @Stephmoralessfit  Join our free Facebook group where go Indepth on all kinds of topics:  https://m.facebook.com/groups/804195770472212/?ref=group_browse   Buy the latest fitness apparel:Valhalla-Athletics (valhalla-athleticsapparel.com)   Apply for 1:1 coaching and get the results you are looking for:  https://www.valhalla-athletics.com  Don't forget to like, share, comment, and leave a 5-star review if you learned something new.

The RCWR Show with Lee Sanders
Episode 967: Logan Paul Wants Roman Reigns! Prelude to AEW Grand Slam! The RCWR Show 9/16/22

The RCWR Show with Lee Sanders

Play Episode Listen Later Sep 17, 2022 136:16


411MANIA.COM reporter & columnist Lee Sanders returns to review AEW RAMPAGE September 16th fallout as Samoa Joe faced Josh Woods in a classic match! Chris Jericho wants the ROH World Championship! And...WWE Smackdown September 16th fallout as Logan Paul vs Roman Reigns is official for Crown Jewel through a Press Conference going down this weekend AND loads more!!!===SUPPORT OUR SPONSORS BELOW AS THEY SUPPORT THIS SHOW===BROUGHT TO YOU IN PART BY THE INTELLIGENCE QUOTES APP VIAhttps://apps.apple.com/us/app/intelligence-quotes/id1625654754VISIT THEIR WEBSITE VIA https://intelligenceapp.square.site/THE INTELLIGENCE QUOTES APP OFFERS FREE DAILY MOTIVATIONAL QUOTES, SPORTS QUOTES, SCHOOL QUOTES, AND INSPIRING QUOTES FROM INFLUENCERS TODAY! DOWNLOAD THE APP TO HAVE ACCESS TO THEIR DATABASE! DOWNLOAD NOW!ONCE AGAIN DOWNLOAD THE INTELLIGENCE QOUTES APP IN THE APPLE STORE!BROUGHT TO YOU IN PART BY NY WEIGHT LOSS MD VIA https://www.nyweightlossmd.com/Do you struggle to Lose weight or do you lose weight only to gain it back again? Have you tried numerous diets and exercise plans unsuccessfully? We know how it's challenging to maintain and lose weight. You are not alone. NY Weight loss MD program is designed to get you results you want in a safe and effective way. The Weight Loss MD program is virtual/online, that's doctor supervised serving all NY residents. No need to leave your home or endure long wait times to see the doctor. Schedule a free online consultation to find out how we can help you.BROUGHT TO YOU IN PART BY TRAVEL AGENT SPECIALIST LE ANDRA BRATTON VIA https://evotravelagent.com/leandra NEED HELP BOOKING FLIGHTS, HOTELS, CRUISES, TOURS, SCORING SOME SWEET SPORT EVENT TICKETS, OR RENTING A CAR? IF YOU'RE ALWAYS ON THE GO AND DON'T REALLY HAVE THE TIME OR ENERGY OR MAYBE YOU NEED SOMEONE THAT'S VERY RESOURCEFUL AND WELL CONNECTED TO DO THE LEGWORK FOR YOU, YOU'VE GOTTA HIT UP MY LE ANDRA! SHE WILL DO HER BEST TO FIND YOU THE BEST DEALS THAT'S OUT THERE WHILE MAKING SURE THE OVERALL EXPERIENCE YOU HAVE WHEREEVER YOU FIND YOURSELF TRAVELING IS A GOOD ONE! ALL WHILE PROVIDING PERSONAL RECCOMMENDATIONS, AND GREAT ATTENTION TO DETAIL! VISIT HER SITE OR GIVE HER A CALL AT 951-525-6010.FOR THE BEST HOSTING SOLUTIONS FOR INDIVIDUALS AND BUSINESSES VISIT ARKHOST.ORG OR ARK.HOST VIA https://arkhost.org/ARKHOST, MOVING AT THE SPEED OF THE WEB! ARKHOST OFFERS SHARED HOSTING, DOMAIN NAMES, VIRTUAL PRIVATE SERVERS, BUSINESS EMAIL HOSTING, WEBSITE SECURITY SOLUTIONS WITH MANY MORE ADDONS AND OPTIONS. ARKHOST FOCUS IS TO PROVIDE YOU THE BEST PERFORMANCE, PLUS AN EASY TO-MANAGE SYSTEM. YOU CAN ALWAYS RELY ON THEIR STATE-OF-THE-ART ENVIRONMENT-FRIENDLY INFRASTUREBROUGHT TO YOU IN PART BY HEALTHYSPIN1.COM VIA https://healthyspin1.com/IF YOU'RE IN NEED OF THE BEST HEALTHY AND DELICIOUS GUMMY VITAMINS WITHOUT THAT NASTY AFTERTASTE AND MADE WITH GREAT QUALITY, YOU'VE GOTTA CHECK OUT HEALTHYSPIN1.COM AND USE PROMO CODE SANDERS15 TO SAVE 15% OFF YOUR ORDER!BROUGHT TO YOU IN PART BY EXPODIGITALS.COM VIA https://www.expodigitals.com/YOUR SOURCE FOR ACCESSING HUNDRES OF DIGITAL PRODUCTS! GET ACCESS TO THEIR ENTIRE LIBRARY OF VIDEO COURSES AND MATERIALS!! WANT TO LEARN ABOUT BOOSTING YOUR IMMUNE SYSTEM? UNDERSTANDING INSTAGRAM OR OTHER PLATFORMS? BOOSTING YOUR ONLINE SALES FOR YOUR ECOMMERCE STORE?EATING HEALTHIER OR WORKING OUT? YOU CAN FIND THAT AND MORE AT EXPODIGITALS.COM YOUR ELEARNING ONLINE MARKETPLACE WHERE YOU CAN PAY ONE LIFETIME FEE TO ACCESS HUNDREDS OF CONTENT, COURSES, AND EBOOKS!BROUGHT TO YOU IN PART BY https://www.cheapsoftwarelicenses.co.ukNeed Microsoft office but can't afford the yearly subscription of £80? Don't worry! Here at Cheap Software Licenses LTD, we will give you a LIFETIME license for only £60! No need to ever renew your license again! If your computer running too slow, outdated or can't play the games your friends are playing with? Show off with the latest high end models at half the retail price! Alienware laptops from only £800! That's 64gb ram, 1tb SSD storage and NVIDIA GeForce RTX 2080! Incredible savings!BROUGHT TO YOU IN PART BY GIVECBDTHANKS.COM VIA https://givecbdthanks.com/IF YOU NEED CBD PRODUCTS FULL OF GREAT QUALITY AND SATISFICATION GUARENTEED, HEAD OVER TO GIVECBDTHANKS.COM GIVECBDTHANKS.COM OFFERS 100% ALL NATURAL CBD OIL AND MOSTLY ORGANIC INGREDIENTS WITH NO PRESERVATIVES! FROM LOLIPOPS, GUMMIES, SHATTERS, GIVECBDTHANKS.COM OFFERS GREAT VARIETY!BROUGHT TO YOU IN PART BY ESHOPONLINEUSA.COM VIA https://www.eshoponlineusa.com/ESHOPONLINEUSA.COM IS YOUR ULTIMATE DESTINATION FOR ALL THINGS MALE ENHANCEMENT SUPPLEMENTS. GET THAT LION ROARING AGAIN AS THEY OFFER SUPPLEMENTS FOR MEN, EVEN SPRAYS, RHINO PILLS, EVEN PRODUCTS FOR HER! ESHOPONLINEUSA.COMBROUGHT TO YOU IN PART BY CORECHAIR.COMTHE CORECHAIR IS GREAT FOR OPTIMIZED SITTING POSTURE. CORECHAIR IS THE ONLY OFFICE CHAIR ON THE MARKET THAT TACKLES SLUMPING, STIMULATES MUSCLES AND SO MUCH MORE! GET A A 60-DAY TRIAL NOW TO TEST OUT THEIR CHAIRS.ALSO BROUGHT TO YOU IN PART BY MYLASTINGWISH.COMLOOKING TO CREAT YOUR OWN WILL THAT'LL DOCUMENT YOUR WANTS AND WISHES? OR MAYBE WANTING TO LEAVE A MESSAGE OR VIDEO WITH FAMILY AND FRIENDS ONCE YOU'RE GONE? MYLASTINGWISH.COM CAN HELP!BROUGHT TO YOU IN PART BY THISDAYINWINEHISTORY.COMThis Day in Wine History is for history and wine lovers alike. If you enjoy pairing world-class wine with award-winning documentaries, then this site is for you! Our articles are broken into DAYS (this day in wine history for all 365 days!), ARTICLES, and IN-DEPTH, which focus on deeper research, academic citations, and longer essays return here for the true history lover!SUPPORT THE SHOW FOR EVEN MORE GREAT, NEW, AND EXCLUSIVE CONTENT! PATREON: patreon.com/rcwrshow​​​​DISCORD CHANNEL: https://rebrand.ly/rcwrshowdiscordLISTEN THE RCWR SHOW ON THE FOLLOWING PLATFORMS:AMAZON MUSIC & AUDIBLE! https://rebrand.ly/jdt4b9vITUNES: https://rb.gy/rsax57PANDORA! https://rb.gy/3v3oc8iHEARTRADIO: https://rb.gy/j0isjnSTITCHER: https://rebrand.ly/rcwrshowstitcherTUNE IN: https://rebrand.ly/fgxyotx===========================FOLLOW THE RCWR SHOW ALL THROUGHOUT SOCIAL MEDIA!!!http://www.twitter.com/TheRCWRshowhttp://www.Twitch.tv/RCWRshowhttp://www.YouTube.com/THERCWRSHOWhttp://www.instagram.com/THERCWRSHOWhttp://www.facebook.com/THERCWRSHOW===========================

KNX In Depth
KNX In Depth: Rick Caruso's massive TV ad budget--Donald Trump and QAnon--Mortgage rates on the rise--JPL's big discovery on Mars

KNX In Depth

Play Episode Listen Later Sep 16, 2022 51:22


Can 17 million dollars worth of television ads sway enough voters to side with Rick Caruso in the LA Mayor's race? He apparently hopes so which is why he's launching a big advertising blitz as he trails in the polls. We go In Depth into whether flooding TV sets with ads will pay off in the end.  Former President Trump seems to be embracing the big QAnon conspiracy theory about him. We look into why.  A judge has finally appointed a Special Master to review those Mar-a-Lago documents. We talk to a lawyer who worked under the person.  If you're hoping a calming of home prices will make for a smaller mortgage payment you're out of luck. Mortgage rates keep going higher.  The line to walk past Queen Elizabeth's coffin is so long that the wait is more than a day and people say they're fine with it.  Doctors and health officials are growing more and more worried about the rollout of the new COVID-19 shots.  Scientists at JPL make a big discovery on Mars.  To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

In Depth
IN DEPTH: Worldclass Triathlete Joyce Burch

In Depth

Play Episode Listen Later Sep 16, 2022 17:00


A local woman is one of the finest triathletes in the world in her age group. Join us today as Dr. Bob Leonard goes “In Depth” with Joyce Burch from Pella.

nowyouknow's podcast
F-150 Lightning vs. Rivian R1T - Electric Pickup Truck Features

nowyouknow's podcast

Play Episode Listen Later Sep 16, 2022 14:01


Go to https://www.freedomraffle.org for your chance to win a 2022 Tesla Model S Plaid! To get the 100 pk of blades for free, make sure to add it to your shopping cart, and use the code 'nowyouknow'. Thanks again to Henson Shaving for sponsoring this episode of In Depth! https://bit.ly/3CMf5Mq Now You Know Clips Channel: https://www.youtube.com/channel/UCacwzDEdpVEO2UjIO00CpqQ Disruptive Investing Channel: https://www.youtube.com/channel/UCTuFDdZdVXgfeZAxTubID0g   Find the shirts that Zac & Jesse are wearing over at Ecowear: https://nowyouknow.ecowear.us/ Use promo code “NowYouKnow” to get your free trial of A Better Route Planner Premium. https://abetterrouteplanner.com/ref/NOWYOUKNOW Check out our Now You Know Clips channel here! https://www.youtube.com/channel/UCacwzDEdpVEO2UjIO00CpqQ Check out Energy Pals here: https://energypal.com/nowyouknow/ Patreon: https://www.patreon.com/nowyouknow #ford #f150lightning #rivian

The RCWR Show with Lee Sanders
Episode 966-Jericho vs Moxley Set for GRAND SLAM! Velveteen Dream Responds! The RCWR Show 9/14/22

The RCWR Show with Lee Sanders

Play Episode Listen Later Sep 15, 2022 127:20


411MANIA.COM reporter & columnist Lee Sanders returns to cover AEW Dynamite September 14th 2022 fallout as Chris Jericho vs Bryan Danielson! Also, Jon Moxley vs Sammy Guevara as the quest to crown a new AEW World Champion draws to a close!! AEW DARK results! Velveteen Dream responds to EC3's allegations! Loads more!!!===SUPPORT OUR SPONSORS BELOW AS THEY SUPPORT THIS SHOW===BROUGHT TO YOU IN PART BY NY WEIGHT LOSS MD VIA https://www.nyweightlossmd.com/Do you struggle to Lose weight or do you lose weight only to gain it back again? Have you tried numerous diets and exercise plans unsuccessfully? We know how it's challenging to maintain and lose weight. You are not alone. NY Weight loss MD program is designed to get you results you want in a safe and effective way. The Weight Loss MD program is virtual/online, that's doctor supervised serving all NY residents. No need to leave your home or endure long wait times to see the doctor. Schedule a free online consultation to find out how we can help you.BROUGHT TO YOU IN PART BY TRAVEL AGENT SPECIALIST LE ANDRA BRATTON VIA https://evotravelagent.com/leandra NEED HELP BOOKING FLIGHTS, HOTELS, CRUISES, TOURS, SCORING SOME SWEET SPORT EVENT TICKETS, OR RENTING A CAR? IF YOU'RE ALWAYS ON THE GO AND DON'T REALLY HAVE THE TIME OR ENERGY OR MAYBE YOU NEED SOMEONE THAT'S VERY RESOURCEFUL AND WELL CONNECTED TO DO THE LEGWORK FOR YOU, YOU'VE GOTTA HIT UP MY LE ANDRA! SHE WILL DO HER BEST TO FIND YOU THE BEST DEALS THAT'S OUT THERE WHILE MAKING SURE THE OVERALL EXPERIENCE YOU HAVE WHEREEVER YOU FIND YOURSELF TRAVELING IS A GOOD ONE! ALL WHILE PROVIDING PERSONAL RECCOMMENDATIONS, AND GREAT ATTENTION TO DETAIL! VISIT HER SITE OR GIVE HER A CALL AT 951-525-6010.FOR THE BEST HOSTING SOLUTIONS FOR INDIVIDUALS AND BUSINESSES VISIT ARKHOST.ORG OR ARK.HOST VIA https://arkhost.org/ARKHOST, MOVING AT THE SPEED OF THE WEB! ARKHOST OFFERS SHARED HOSTING, DOMAIN NAMES, VIRTUAL PRIVATE SERVERS, BUSINESS EMAIL HOSTING, WEBSITE SECURITY SOLUTIONS WITH MANY MORE ADDONS AND OPTIONS. ARKHOST FOCUS IS TO PROVIDE YOU THE BEST PERFORMANCE, PLUS AN EASY TO-MANAGE SYSTEM. YOU CAN ALWAYS RELY ON THEIR STATE-OF-THE-ART ENVIRONMENT-FRIENDLY INFRASTUREBROUGHT TO YOU IN PART BY HEALTHYSPIN1.COM VIA https://healthyspin1.com/IF YOU'RE IN NEED OF THE BEST HEALTHY AND DELICIOUS GUMMY VITAMINS WITHOUT THAT NASTY AFTERTASTE AND MADE WITH GREAT QUALITY, YOU'VE GOTTA CHECK OUT HEALTHYSPIN1.COM AND USE PROMO CODE SANDERS15 TO SAVE 15% OFF YOUR ORDER!BROUGHT TO YOU IN PART BY EXPODIGITALS.COM VIA https://www.expodigitals.com/YOUR SOURCE FOR ACCESSING HUNDRES OF DIGITAL PRODUCTS! GET ACCESS TO THEIR ENTIRE LIBRARY OF VIDEO COURSES AND MATERIALS!! WANT TO LEARN ABOUT BOOSTING YOUR IMMUNE SYSTEM? UNDERSTANDING INSTAGRAM OR OTHER PLATFORMS? BOOSTING YOUR ONLINE SALES FOR YOUR ECOMMERCE STORE?EATING HEALTHIER OR WORKING OUT? YOU CAN FIND THAT AND MORE AT EXPODIGITALS.COM YOUR ELEARNING ONLINE MARKETPLACE WHERE YOU CAN PAY ONE LIFETIME FEE TO ACCESS HUNDREDS OF CONTENT, COURSES, AND EBOOKS!BROUGHT TO YOU IN PART BY https://www.cheapsoftwarelicenses.co.ukNeed Microsoft office but can't afford the yearly subscription of £80? Don't worry! Here at Cheap Software Licenses LTD, we will give you a LIFETIME license for only £60! No need to ever renew your license again! If your computer running too slow, outdated or can't play the games your friends are playing with? Show off with the latest high end models at half the retail price! Alienware laptops from only £800! That's 64gb ram, 1tb SSD storage and NVIDIA GeForce RTX 2080! Incredible savings!BROUGHT TO YOU IN PART BY GIVECBDTHANKS.COM VIA https://givecbdthanks.com/IF YOU NEED CBD PRODUCTS FULL OF GREAT QUALITY AND SATISFICATION GUARENTEED, HEAD OVER TO GIVECBDTHANKS.COM GIVECBDTHANKS.COM OFFERS 100% ALL NATURAL CBD OIL AND MOSTLY ORGANIC INGREDIENTS WITH NO PRESERVATIVES! FROM LOLIPOPS, GUMMIES, SHATTERS, GIVECBDTHANKS.COM OFFERS GREAT VARIETY!BROUGHT TO YOU IN PART BY ESHOPONLINEUSA.COM VIA https://www.eshoponlineusa.com/ESHOPONLINEUSA.COM IS YOUR ULTIMATE DESTINATION FOR ALL THINGS MALE ENHANCEMENT SUPPLEMENTS. GET THAT LION ROARING AGAIN AS THEY OFFER SUPPLEMENTS FOR MEN, EVEN SPRAYS, RHINO PILLS, EVEN PRODUCTS FOR HER! ESHOPONLINEUSA.COMBROUGHT TO YOU IN PART BY CORECHAIR.COMTHE CORECHAIR IS GREAT FOR OPTIMIZED SITTING POSTURE. CORECHAIR IS THE ONLY OFFICE CHAIR ON THE MARKET THAT TACKLES SLUMPING, STIMULATES MUSCLES AND SO MUCH MORE! GET A A 60-DAY TRIAL NOW TO TEST OUT THEIR CHAIRS.ALSO BROUGHT TO YOU IN PART BY MYLASTINGWISH.COMLOOKING TO CREAT YOUR OWN WILL THAT'LL DOCUMENT YOUR WANTS AND WISHES? OR MAYBE WANTING TO LEAVE A MESSAGE OR VIDEO WITH FAMILY AND FRIENDS ONCE YOU'RE GONE? MYLASTINGWISH.COM CAN HELP!BROUGHT TO YOU IN PART BY THISDAYINWINEHISTORY.COMThis Day in Wine History is for history and wine lovers alike. If you enjoy pairing world-class wine with award-winning documentaries, then this site is for you! Our articles are broken into DAYS (this day in wine history for all 365 days!), ARTICLES, and IN-DEPTH, which focus on deeper research, academic citations, and longer essays return here for the true history lover!SUPPORT THE SHOW FOR EVEN MORE GREAT, NEW, AND EXCLUSIVE CONTENT! PATREON: patreon.com/rcwrshow​​​​DISCORD CHANNEL: https://rebrand.ly/rcwrshowdiscordLISTEN THE RCWR SHOW ON THE FOLLOWING PLATFORMS:AMAZON MUSIC & AUDIBLE! https://rebrand.ly/jdt4b9vITUNES: https://rb.gy/rsax57PANDORA! https://rb.gy/3v3oc8iHEARTRADIO: https://rb.gy/j0isjnSTITCHER: https://rebrand.ly/rcwrshowstitcherTUNE IN: https://rebrand.ly/fgxyotx===========================FOLLOW THE RCWR SHOW ALL THROUGHOUT SOCIAL MEDIA!!!http://www.twitter.com/TheRCWRshowhttp://www.Twitch.tv/RCWRshowhttp://www.YouTube.com/THERCWRSHOWhttp://www.instagram.com/THERCWRSHOWhttp://www.facebook.com/THERCWRSHOW===========================

ChirpCast Podcast
In Depth with Ball State (Football Week 3 vs. Murray State)

ChirpCast Podcast

Play Episode Listen Later Sep 15, 2022 2:19


In Depth with Ball State is a weekly preview of Ball State Football's next opponent.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

KNX In Depth
KNX In Depth: LA County Sheriff Alex Villanueva defends search of Supervisor Sheila Kuehl's home--Multivitamins and brain health--Hollywood and Queen Elizabeth--Iowa radio legend Pat Powers on 44 years at the same station

KNX In Depth

Play Episode Listen Later Sep 15, 2022 49:38


LA County Supervisor Sheila Kuehl goes on the offensive, slamming the search of her home by sheriff's investigators as a politically motivated act by the sheriff himself--Alex Villanueva--who's had several conflicts with the Board of Supervisors. A court affidavit shows the search is connected to non-competitive contracts awarded by Metro to a nonprofit organization run by a friend of Kuehl's. We go In Depth to sort this out with Sheriff Villanueva.  Working from home, higher rent and sky high home prices are just some of the impacts the pandemic has had around the country. We look into the results of a big new survey.  Russia and China are getting closer. Their two leaders met today with one criticizing the U.S.  A new study finds a positive impact on brain health through a daily multivitamin. We go In Depth into what was found.  Could the death of Queen Elizabeth lead to less interest from Hollywood and the American public in Britain's royal family?  We end the show by talking to a radio legend most people here probably have never heard of--until now. He's been at the same radio station in the Midwest for 44 years. Pat Powers is a master story teller who will share what he's seen during that time in his home state of Iowa, the country and the world.  To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

Rocky Mountain Calvary Podcast

Luke 4:13. Wednesday night - In-Depth study.

Physician's Weekly Podcast
An inDEPTH Look at Lymphoma

Physician's Weekly Podcast

Play Episode Listen Later Sep 14, 2022 24:23


September 15 is World Lymphoma Awareness Day, with the theme We Can't Wait. To honor the leaps and bounds that research into this rare cancer has made, today's podcast views the current state of lymphoma through different lenses. First, Dr. Constantine Tam, Head of Lymphoma Service at Alfred Hospital and Professor of Hematology at Monash University in Melbourne, Australia talks about the SEQUOIA trial on the efficacy of BTK inhibitor zanubrutinib versus bendamustine and rituximab in untreated chronic lymphocytic leukemia and small lymphocytic lymphoma, recently published in Lancet Oncology. Also, Lorna Warwick, CEO of the Lymphoma Coalition, based in Canada as a federation of more than 80 lymphoma patient organizations worldwide that runs the World Lymphoma Awareness Day project, discusses the more than 80 subtypes of non-Hodgkin's lymphoma. She has some great insights into the unmet needs of patients with lymphoma and how to budge the needle on care.Enjoy listening!

KNX In Depth
KNX In Depth: Congress members and questions over stock trades--White collar layoffs--Queen Elizabeth and colonialism--CDC health warning and kids--Is Christianity on the decline?

KNX In Depth

Play Episode Listen Later Sep 14, 2022 48:34


Have you ever wondered how so many former members of Congress leave Washington D.C. far wealthier than when they got there? Well, a New York Times analysis may help answer that question. It found 97 lawmakers or their families bought or sold financial assets over a three-year span in industries that could be affected by their legislative committee work. One of them is Senator Dianne Feinstein. Two others are House members here in southern California. We go In Depth.  That looming rail workers strike could have a major immediate impact on the economy.  Speaking of the economy, we could soon see a spike in layoffs in the white collar world.  Queen Elizabeth has left Buckingham Palace for the final time. People are now lining up in London to view her coffin and pay their final respects.  The death of the queen has raised issues about colonialism. We go In Depth into the queen's legacy when it comes to that issue.  The CDC has a new health alert about respiratory illnesses in kids and the chance of them developing something even worse.  More and more people around the country are no longer identifying as Christian. We try to find out why.  To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

RNZ: Morning Report
Minister wants credit cards banned for online gambling

RNZ: Morning Report

Play Episode Listen Later Sep 14, 2022 3:18


The Minister of Internal Affairs Jan Tinetti wants Lotto to ban the use of credit cards for online gambling. But Lotto says it doesn't want to impose that on its customers and claims it already has some of the strongest safeguards of any state lottery in the world. Guyon Espiner has been investigating Lotto as part of a series for RNZ's In Depth team, and filed this report.

The RCWR Show with Lee Sanders
Episode 965-Damage Control Captures Gold! Ric Flair Goodie Unboxing | The RCWR Show 9/12/22

The RCWR Show with Lee Sanders

Play Episode Listen Later Sep 14, 2022 93:11


Hosted by 411MANIA.COM reporter and columnist Lee Sanders. WWE RAW September 12th 2022 fallout as Damage Control (Bayley's Delights) capture tag team gold! AEW Dark Elevation card for this week, Ric Flair goodie unboxing, heads up about an almost lost episode of WRESTLING with the TOPICS, wrestling ratings are in for last week and loads more!!!===SUPPORT OUR SPONSORS BELOW AS THEY SUPPORT THIS SHOW===BROUGHT TO YOU IN PART BY NY WEIGHT LOSS MD VIA https://www.nyweightlossmd.com/Do you struggle to Lose weight or do you lose weight only to gain it back again? Have you tried numerous diets and exercise plans unsuccessfully? We know how it's challenging to maintain and lose weight. You are not alone. NY Weight loss MD program is designed to get you results you want in a safe and effective way. The Weight Loss MD program is virtual/online, that's doctor supervised serving all NY residents. No need to leave your home or endure long wait times to see the doctor. Schedule a free online consultation to find out how we can help you. BROUGHT TO YOU IN PART BY TRAVEL AGENT SPECIALIST LE ANDRA BRATTON VIA https://evotravelagent.com/leandra NEED HELP BOOKING FLIGHTS, HOTELS, CRUISES, TOURS, SCORING SOME SWEET SPORT EVENT TICKETS, OR RENTING A CAR? IF YOU'RE ALWAYS ON THE GO AND DON'T REALLY HAVE THE TIME OR ENERGY OR MAYBE YOU NEED SOMEONE THAT'S VERY RESOURCEFUL AND WELL CONNECTED TO DO THE LEGWORK FOR YOU, YOU'VE GOTTA HIT UP MY LE ANDRA! SHE WILL DO HER BEST TO FIND YOU THE BEST DEALS THAT'S OUT THERE WHILE MAKING SURE THE OVERALL EXPERIENCE YOU HAVE WHEREEVER YOU FIND YOURSELF TRAVELING IS A GOOD ONE! ALL WHILE PROVIDING PERSONAL RECCOMMENDATIONS, AND GREAT ATTENTION TO DETAIL! VISIT HER SITE OR GIVE HER A CALL AT 951-525-6010.FOR THE BEST HOSTING SOLUTIONS FOR INDIVIDUALS AND BUSINESSES VISIT ARKHOST.ORG OR ARK.HOST VIA https://arkhost.org/ARKHOST, MOVING AT THE SPEED OF THE WEB! ARKHOST OFFERS SHARED HOSTING, DOMAIN NAMES, VIRTUAL PRIVATE SERVERS, BUSINESS EMAIL HOSTING, WEBSITE SECURITY SOLUTIONS WITH MANY MORE ADDONS AND OPTIONS. ARKHOST FOCUS IS TO PROVIDE YOU THE BEST PERFORMANCE, PLUS AN EASY TO-MANAGE SYSTEM. YOU CAN ALWAYS RELY ON THEIR STATE-OF-THE-ART ENVIRONMENT-FRIENDLY INFRASTUREBROUGHT TO YOU IN PART BY HEALTHYSPIN1.COM VIA https://healthyspin1.com/IF YOU'RE IN NEED OF THE BEST HEALTHY AND DELICIOUS GUMMY VITAMINS WITHOUT THAT NASTY AFTERTASTE AND MADE WITH GREAT QUALITY, YOU'VE GOTTA CHECK OUT HEALTHYSPIN1.COM AND USE PROMO CODE SANDERS15 TO SAVE 15% OFF YOUR ORDER!BROUGHT TO YOU IN PART BY EXPODIGITALS.COM VIA https://www.expodigitals.com/YOUR SOURCE FOR ACCESSING HUNDRES OF DIGITAL PRODUCTS! GET ACCESS TO THEIR ENTIRE LIBRARY OF VIDEO COURSES AND MATERIALS!! WANT TO LEARN ABOUT BOOSTING YOUR IMMUNE SYSTEM? UNDERSTANDING INSTAGRAM OR OTHER PLATFORMS? BOOSTING YOUR ONLINE SALES FOR YOUR ECOMMERCE STORE?EATING HEALTHIER OR WORKING OUT? YOU CAN FIND THAT AND MORE AT EXPODIGITALS.COM YOUR ELEARNING ONLINE MARKETPLACE WHERE YOU CAN PAY ONE LIFETIME FEE TO ACCESS HUNDREDS OF CONTENT, COURSES, AND EBOOKS!BROUGHT TO YOU IN PART BY https://www.cheapsoftwarelicenses.co.ukNeed Microsoft office but can't afford the yearly subscription of £80? Don't worry! Here at Cheap Software Licenses LTD, we will give you a LIFETIME license for only £60! No need to ever renew your license again! If your computer running too slow, outdated or can't play the games your friends are playing with? Show off with the latest high end models at half the retail price! Alienware laptops from only £800! That's 64gb ram, 1tb SSD storage and NVIDIA GeForce RTX 2080! Incredible savings!BROUGHT TO YOU IN PART BY GIVECBDTHANKS.COM VIA https://givecbdthanks.com/IF YOU NEED CBD PRODUCTS FULL OF GREAT QUALITY AND SATISFICATION GUARENTEED, HEAD OVER TO GIVECBDTHANKS.COM GIVECBDTHANKS.COM OFFERS 100% ALL NATURAL CBD OIL AND MOSTLY ORGANIC INGREDIENTS WITH NO PRESERVATIVES! FROM LOLIPOPS, GUMMIES, SHATTERS, GIVECBDTHANKS.COM OFFERS GREAT VARIETY!BROUGHT TO YOU IN PART BY ESHOPONLINEUSA.COM VIA https://www.eshoponlineusa.com/ESHOPONLINEUSA.COM IS YOUR ULTIMATE DESTINATION FOR ALL THINGS MALE ENHANCEMENT SUPPLEMENTS. GET THAT LION ROARING AGAIN AS THEY OFFER SUPPLEMENTS FOR MEN, EVEN SPRAYS, RHINO PILLS, EVEN PRODUCTS FOR HER! ESHOPONLINEUSA.COMBROUGHT TO YOU IN PART BY CORECHAIR.COMTHE CORECHAIR IS GREAT FOR OPTIMIZED SITTING POSTURE. CORECHAIR IS THE ONLY OFFICE CHAIR ON THE MARKET THAT TACKLES SLUMPING, STIMULATES MUSCLES AND SO MUCH MORE! GET A A 60-DAY TRIAL NOW TO TEST OUT THEIR CHAIRS.ALSO BROUGHT TO YOU IN PART BY MYLASTINGWISH.COMLOOKING TO CREAT YOUR OWN WILL THAT'LL DOCUMENT YOUR WANTS AND WISHES? OR MAYBE WANTING TO LEAVE A MESSAGE OR VIDEO WITH FAMILY AND FRIENDS ONCE YOU'RE GONE? MYLASTINGWISH.COM CAN HELP!BROUGHT TO YOU IN PART BY THISDAYINWINEHISTORY.COMThis Day in Wine History is for history and wine lovers alike. If you enjoy pairing world-class wine with award-winning documentaries, then this site is for you! Our articles are broken into DAYS (this day in wine history for all 365 days!), ARTICLES, and IN-DEPTH, which focus on deeper research, academic citations, and longer essays return here for the true history lover!SUPPORT THE SHOW FOR EVEN MORE GREAT, NEW, AND EXCLUSIVE CONTENT! PATREON: patreon.com/rcwrshow​​​​DISCORD CHANNEL: https://rebrand.ly/rcwrshowdiscordLISTEN THE RCWR SHOW ON THE FOLLOWING PLATFORMS:AMAZON MUSIC & AUDIBLE! https://rebrand.ly/jdt4b9vITUNES: https://rb.gy/rsax57PANDORA! https://rb.gy/3v3oc8iHEARTRADIO: https://rb.gy/j0isjnSTITCHER: https://rebrand.ly/rcwrshowstitcherTUNE IN: https://rebrand.ly/fgxyotx===========================FOLLOW THE RCWR SHOW ALL THROUGHOUT SOCIAL MEDIA!!!http://www.twitter.com/TheRCWRshowhttp://www.Twitch.tv/RCWRshowhttp://www.YouTube.com/THERCWRSHOWhttp://www.instagram.com/THERCWRSHOWhttp://www.facebook.com/THERCWRSHOW===========================

KNX In Depth
KNX In Depth: Stocks tumble following the latest inflation numbers--King Charles III built a financial empire--Sick sea lions--LA County monkeypox death

KNX In Depth

Play Episode Listen Later Sep 13, 2022 49:08


The latest inflation numbers are out and Wall Street isn't too thrilled. Consumer prices surged more than eight percent in August compared to a year earlier. That rate is down from a four-decade high of just over nine percent in June but investors didn't react well as the Dow plunged downward today. We go In Depth into inflation.  King Charles apparently refused to sit idly by over the years and count his riches. He took his wealth and turned it into even more wealth. We look into how.  LA County is now home to the first confirmed monkeypox death in the country.   Hundreds of sea lions off the coast of southern California are getting sick because of toxic algae. We go In Depth into how this is being called an emergency by wildlife experts.  Companies may soon be required to post pay ranges on their job ads in California. We look into how that could impact work morale.  The Emmys last night show just how far the big four networks have fallen.  French film director Jean-Luc Godard has died. We look into the legacy of one of the most influential people in movie industry history.  To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

Circulation on the Run
Circulation September 13, 2022 Issue

Circulation on the Run

Play Episode Listen Later Sep 12, 2022 25:28 Very Popular


This week, please join authors Svati Shah and Senthil Selvaraj as well as Guest Editor and Editorialist Manuel Mayr as they discuss the article "Metabolomic Profiling of the Effects of Dapagliflozin in Heart Failure With Reduced Ejection Fraction: DEFINE-HF" and the editorial "SGLT2 Inhibitors in Heart Failure: Targeted Metabolomics and Energetic Metabolism." Dr. Carolyn Lam: Welcome to Circulation On Run, your weekly podcast summary and backstage pass to the journal and its editors. We're your co-hosts, I'm Dr. Carolyn Lam, Associate Editor from the National Heart Center and Duke National University of Singapore. Dr. Greg Hundley: And I'm Dr. Greg Hundley, Associate Editor, Director of the Pauley Heart Center at VCU Health Richmond, Virginia. Dr. Carolyn Lam: In today's feature paper, we will be talking about the metabolomic profiling of the effects of dapagliflozin in heart failure, and this is from the DEFINE-HF trial. It's just such a cool paper with a lot of insights you have to hear from the authors. But, before we get there, let's talk about some of the other papers in today's issue. Shall we, Greg? Dr. Greg Hundley: You bet, Carolyn. Well, how about if I go first? Dr. Carolyn Lam: Please. Dr. Greg Hundley: Thank you, Carolyn. My first paper comes to us from Professor Paulus Kirchhof from the Universitäres Herzzentrum in Hamburg. Carolyn, in the randomized EAST-AFNET 4 study, so the early treatment of atrial fibrillation for stroke prevention, these trial investigators demonstrated that systematic initiation of early rhythm control reduced adverse cardiovascular outcomes in patients with recently diagnosed atrial fibrillation and stroke risk factors. However, the effectiveness and safety of early rhythm control in patients with multiple cardiovascular comorbidities is not known. Carolyn, in this study, it was a prespecified sub-analysis of the EAST-AFNET 4 trial and it compared the effectiveness and safety of early rhythm control with usual care stratified into patients with high CHA2DS2-VASc scores of greater than or equal to 4. Dr. Carolyn Lam: Nice. Okay. Important question, what did they find? Dr. Greg Hundley: Right, Carolyn. Quite a bit of data in this study, so let's walk through it carefully. First, in regards to the study population, the EAST-AFNET 4 randomized 1093 patients with CHA2DS2-VASc scores of greater than or equal to 4, these were predominantly women, 61% female, and then also 1,696 patients with CHA2DS2-VASc of less than four, and these were predominantly men, so only 37% women. Now let's get to the date. Early rhythm control reduced the composite primary efficacy outcome of cardiovascular death, stroke, or hospitalization for worsening heart failure or for acute coronary syndrome in patients with high CHA2DS2-VASc scores of greater than 4, but not in patients with CHA2DS2-VASc scores of less than 4. Second, now Carolyn, the primary safety outcome, so death, stroke, or serious adverse events of rhythm control therapy, was not different between study groups in patients with high CHA2DS2-VASc scores of greater than 4, but occurred more often in patients with low CHA2DS2-VASc scores randomized to early rhythm control. Now Carolyn, life threatening events or death were not different between the groups. When female sex was ignored for the creation of high and lower groups, the interaction P was not significant for the primary efficacy outcome, but remained significant for the primary safety outcome. Dr. Carolyn Lam: Oh, you are right. A lot of interesting data here. What's a take home message? Dr. Greg Hundley: Right, Carolyn. So the take home message is the following. Patients with recently diagnosed atrial fibrillation and multiple cardiovascular comorbidities should be considered to have priority access to early rhythm control to reduce cardiovascular outcomes, and a specific trial of early rhythm control in these patients is really needed as a next step. Dr. Carolyn Lam: Oh, thank you, Greg. The next paper focuses on arrhythmogenic right ventricular cardiomyopathy, which we know is characterized by a high propensity to life threatening arrhythmias and progressive loss of heart muscle. More than 40% of reported genetic variants linked to arrhythmogenic right ventricular cardiomyopathy, or ARVC, reside in a gene called plakophilin-2, or PKP2. In today's paper, Dr. Delmar and Lundby from NYU Grossman School of Medicine and University of Copenhagen, respectively, and their colleagues, described a comprehensive characterization of the ARVC molecular landscape using a multidisciplinary approach including human samples from ARVC patients with PKP2 mutations and left ventricular ejection fraction above 45%, as well as PKP2-deficient murine and human induced pluripotent stem cell-derived cardiomyocytes. They studied all of these with comprehensive proteomics and functional analysis. Dr. Greg Hundley: Wow, Carolyn, another great study in circulation combining both preclinical murine models as well as data from human subjects. So, what did they find? Dr. Carolyn Lam: Precisely, Greg. Here's what they found. Loss of nuclear envelope integrity and subsequent DNA damage is a key substrate in the molecular pathology of AR VC. The authors further showed transcriptional down regulation of proteins of the electron transcript chain as an early event in the molecular pathophysiology of the disease prior to an ejection fraction falling below 45%. This associates with increased oxidant production, with the clinical message being, therefore, that the authors propose therapies that limit oxidant formation may be a possible intervention to restrict DNA damage in ARVC. Dr. Greg Hundley: Very nice, Carolyn. Okay, our next paper comes from Dr. Donald Lloyd-Jones from Northwestern University, the Feinberg School of Medicine. Carolyn, you can tell the change in inflection of my voice because it's time for another Carolyn's quiz. Carolyn, open-ended question. Can you remind us of life's essential eight? Dr. Carolyn Lam: Oh boy, Greg. It's like asking me to name the dwarfs. I know I'm going to forget one, but here you go. Diet, exercise, cholesterol, weight, smoking, sugar must be there, diabetes, blood pressure. You see, I got seven. What's the eighth? Dr. Greg Hundley: Yeah. Remember seven dwarfs, Sleepy. Dr. Carolyn Lam: Sleep. Dr. Greg Hundley: Very good. Great job, Carolyn. Dr. Carolyn Lam: Thank you. Dr. Greg Hundley: Recently, the American Heart Association recently published an updated algorithm for quantifying cardiovascular health, the Life's Essential 8 score. In this study, the investigative team quantified US levels of cardiovascular health using the new score. They included non-pregnant, non-institutionalized individuals aged 2 through 79 years who were free of cardiovascular disease from the National Health and Nutrition Examination Surveys that were conducted between 2013 and 2018. Now, for all participants, they calculated the overall cardiovascular health score, and it ranged from 0, which is really low, to 100, which is the highest, as well as the score for each component. And Carolyn, yes, you are very close. Remember the eight? Diet, physical activity, nicotine exposure, sleep duration, body mass index, blood lipids, blood glucose, and blood pressure, and they used published American Heart Association definitions of these. The cardiovascular health scores were assessed across strata of age, sex, race, ethnicity, family income, and depression. Dr. Carolyn Lam: Okay, Greg. What did they find? Dr. Greg Hundley: Right, Carolyn. There were 23,400 plus participants, representing 201,728,000 adults and 74 million children. The overall mean cardiovascular health score was 64.7 among adults using all eight metrics, and it was 65.5 for the three metrics available of diet, physical activity, and BMI among the children and adolescents that were aged 2 through 19 years. Now, for the adults there were significant differences in mean cardiovascular health scores by sex, age, and racial ethnic group. Mean scores were lowest for diet, physical activity, and the BMI metrics. There were large differences in mean scores across demographic groups for diet, nicotine exposure, blood glucose, and blood pressure. In children, diet scores were low, 40.6, and were progressively lower in higher age groups. Large differences were also noted in mean physical activity and BMI by sociodemographic group. Carolyn, this study basically identifies wide ranges of scores across multiple domains of the essential eight, and thus, this new Life's Essential 8 score helps identify large group and individual differences in cardiovascular health. Additionally, overall, cardiovascular health in the US population remains well below optimal levels, and there are both broad and targeted opportunities to monitor, preserve, and improve cardiovascular health across the life course in both individuals, as well as the population at large. Dr. Carolyn Lam: Wow. Thanks, Greg. Truly really interesting. Everyone's going to have to pick up that paper and all the other papers in this issue, because there's also an In Depth paper by Dr. Whelton on “Harmonization of the ACC/AHA and ESC/ESH Blood Pressure Hypertension Guidelines, Comparisons, Reflections, and Recommendations. There's a Research Letter by Dr. Munshi on the accurate classification of cardiomyopathy etiology by chromatin accessibility. Dr. Greg Hundley: Carolyn, I have got to report an exchange of letters from Professor Sun and Weng regarding the article, “Legumain Is an Endogenous Modulator of Integrin αvβ3 Triggering Vascular Degeneration, Dissection, and Rupture.” And then Carolyn, lastly, there's a Perspective piece from Professor Vidal-Petiot entitled, “Thresholds for Hypertension Definition, Treatment Initiation, and Treatment Targets: Recent Guidelines at a Glance.” Well, Carolyn, how about we get on to that feature discussion? Dr. Carolyn Lam: Yes, let's go Greg. Wow, we have a star stud cast for today's feature discussion, and on a star studied topic, if I may. It's on the SGLT2 inhibitors, this time in the DEFINE-HF study and really going into the mechanism of action of SGLT2 inhibitors. Now, that's one question I personally get all the time. How do these things work? Today's paper brings us one step closer, for sure, in the understanding. I'm so grateful to have the first author, Dr. Senthil Selvaraj from University of Pennsylvania, as well as the corresponding author of the paper, Dr. Svati Shah, associate editor, as well as the corresponding author from Duke Molecular Physiology Institute. We also have Dr. Manuel Mayr who was both the guest editor and editorialist for this paper, and Dr. Mayr is from Kings College London, British Heart Foundation Center. Welcome, everyone. Senthil, get us started here. The DEFINE-HF study, just a quick summary, what that was about and then what you did, what you found. Dr. Senthil Selvaraj: Absolutely. Good morning, everyone, or maybe good evening for your time, Carolyn, but we were very excited about this study and the ability to do targeted metabolomic profiling in DEFINE. This audience is well familiar with the fact that SGLT2 inhibitors are foundational therapy in heart failure reduced ejection fraction, and the interesting thing is, despite a lot of literature, we still don't know why. Whether it relates to change in inflammation or endothelial function, but given the mechanism of action, metabolism is sort of at its core. So in this study we sought to identify metabolic pathways that were associated with dapagliflozin treatment using this targeted metabolomics platform in which we assayed 63 metabolites, acylcarnitine, which are markers of fatty acid oxidation, several amino acids, and ketone-related metabolites. To do this, we studied 234 participants from DEFINE, which is a 12-week placebo-controlled trial of dapagliflozin in this population, and we perform principal components analysis for dimensionality reduction techniques. In this study, briefly we found that, first, our principal components analysis yielded 13 different factors that accounted for the substantial proportion in the variation of the data, and that two in particular, ketone-related metabolites and short acylcarnitines in factor 6, as well as medium-chain acylcarnitines in factor 7 were differentially associated with dapagliflozin treatment. Specifically, there were increases in several ketone-related metabolites and short acylcarnitines, as well as several medium-chain acylcarnitines, really speaking to, potentially, changes in fatty acid as well as ketone biology with dapagliflozin treatment. The second aim of our study was to look at changes in metabolites and changes in endpoint studying DEFINE, which included NT-proBNP as well as KCCQ scores. We found that dicarboxylate long-chain acylcarnitines and aromatic amino acids really related to worsening heart failure endpoints there. So, a lot to impact, a lot that we found, and appreciative about the opportunity. Dr. Carolyn Lam: Oh, wow. Thank you so much for that amazing summary. Svati, I've heard you speak so many times on metabolomics on our calls, but this is really so important. First, I think the question is, congratulations for thinking ahead of time to collect the samples and to do all of this. Congratulations on that. Could I ask if you went in with any specific hypothesis or were you surprised by these findings, Svati? Dr. Svati Shah: Yeah, Carolyn, thank you so much. It was such a pleasure to work with Senthil on this and I really want to highlight what an incredible early career investigator he is. He's really going to set the metabolism world on fire. I also wanted to say thank you to the PI of the clinical trial, the parent clinical trial DEFINE-HF Mikhail Kosiborod, who did the really hard work of collecting the samples along with the clinical trial itself. To me, what's really cool is to be able to take a clinical trial like this with really important clinical outcomes well adjudicated and to be able to dig into the mechanism at a metabolic level of what might be going on with SGLT2 inhibitors. Going into this, Carolyn, we suspected that ketone-related biology was at play. There have been studies in other populations, non-HFrEF populations, that have shown that SGLT2 inhibitors have what appears to be beneficial impacts on ketone biology and induced ketosis. So, going into this, we suspected that this ketone pathway was going to come up. I think what's exciting is, not only did we find that the ketone pathway was differential modified by dapagliflozin, but that it wasn't at the level of severe ketosis that we would be concerned about. And then secondly, we found pathways of fatty acid oxidation. Some related to the effects of the medication and some related to changes in functional outcome. So it really enhanced beyond what we already knew about ketone biology, expanded our understanding of potential mechanisms of SGLT2 inhibitors, and expanded this into the HFrEF space, Carolyn. Dr. Carolyn Lam: Oh, that's so nice. I'm bursting with questions, but I really, really have to ask Dr. Manuel Mayr, first, could you put these findings into context for us and tell us what they mean clinically? Dr. Manuel Mayr: Yeah, Carolyn. First of all, I want to join you in congratulating the authors to this important study. As Svati mentioned, previous studies have reported effects of SGLT2 inhibitors on ketone bodies, but the present study really adds to the literature because it uses the state of the art metabolomic techniques. It uses a technique called mass spectrometry, but they also have a rating of, I think, in total, 63 metabolites in over 200 patients. Mass spectrometry is becoming increasingly important for cardiovascular precision medicine because we can use it in clinical trials to provide an unbiased assessment of metabolites and proteins. So it's a very versatile technology. I think this study really adds to the rapidly growing literature that SGLT2 inhibition is a principle of unloading the failing heart from metabolic stress. Dr. Carolyn Lam: Wow, I really like that and your editorial is just beautiful. I love that you say, "After the serendipitous findings of improved heart failure outcomes with SGLT2 inhibitors, mechanisms were postulated, but studies, such as the one we're discussing, are needed to really uncover what's the real thing." Now, I know this may sound really oversimplified and so on, but I'd really love for Senthil or Svati to just bear with me as I ask, what are you going to say to people who go, "Okay, then we should just be downing ketones," Or, "We should be Working on the fatty acid parts of it," Or taking conclusions like that. What would you say to something like that? Dr. Senthil Selvaraj: I'm happy to go first. It's a really wonderful question and I do think that this study raises the question of whether we should be exogenously increasing ketone levels to provide some sort of benefit. I would say the jury's still out there. I think it's a hot topic right now. But there are also differences between how we raise key tone levels, whether you do that endogenously in the body, or whether you give something like a ketone supplement, so exogenous ketone supplementation. And I think that there are completely different physiologies there. So more to come. I think there are a lot of studies in this space. The ketogenic diet is something that I'm often asked as well, whether that might provide benefit to heart failure. There are a lot of ways that I can, but one thing that we need to be mindful of is the fact that it will reduce glycogen stores as well, which may impact exercise capacity. So, we need more data. I would say the other thing that we found in our studies, while they were increased in ketone levels and markers of fatty acid oxidation with dapagliflozin treatment, we aren't necessarily sure that those mediate the benefits of SGLT2 inhibitors. DEFINE has important clinically relevant endpoints, but it is not an event-based trial. And so we don't know and we can't link the changes in metabolites with changes in outcomes quite yet. Dr. Svati Shah: Carolyn, just to add to the wonderful response that Senthil just gave, I think we do have to be careful. We don't know whether these are direct effects of SGLT2 inhibitors or whether these are related to the caloric loss that we know happens with these medications. I think it's important to point out that we're looking in the blood, we don't actually know what's happening at the tissue level, so we do have to be a little bit careful. We have made inferences that this is reporting on substrate fuel selection in the heart, but we also suspect that skeletal muscle and other organs are heavily involved in some of the pathways we're seeing. So I just wanted to make those important caveat to the epidemiologic work that we do. Dr. Carolyn Lam: And those are so important, so thank you Senthil and Svati. Manuel, I'd love to invite your thoughts because you did sort of point out some of these points in your editorial. Could you maybe discuss a bit of those and raise any questions, perhaps? Dr. Manuel Mayr: Yes. I think Svati and Senthil have nicely mentioned already that these measurements are performed in plasma. So the changes in plasma could be due to, for example, increased production in the liver due to decreased consumption in other tissues. So I guess the next step would be, and I would be really interested on what the authors want to pursue, is to provide direct evidence for the energetic hypothesis, that really the heart is consuming these keto bodies and what type of measurements could be performed to provide direct evidence in humans for these metabolic hypothesis. Dr. Senthil Selvaraj: That's a really great question, Manuel. There was a really nice study that was published about a year or two ago in Science in which the authors did coronary sinus sampling. So really to get arterial venous gradients, measure substances in the arterial system as well as the coronary sinus venous system and get extraction. I think that that study would be very interesting to understand. You take patients on SGLT2 inhibitors, those who are not, and to understand what is the heart chewing on. Obviously more invasive than some other approaches, but other studies that I think would be really interesting in those space would be flux studies and stable isotope studies. Again, as Svati really nicely mentioned, these are systemic physiology snapshots whenever we do less localized techniques like that, but they're still very important because heart failure is a systemic process. Dr. Carolyn Lam: Anything to add, Svati? Dr. Svati Shah: No, I think you said it beautifully. I'll just say on the sort of epidemiologic side, to be able to link this to harder outcomes, DEFINE-HF wasn't really designed to be able to do that. So as we expand our understanding of SGLT2 inhibitors, understand different populations, and to link these pathways to more objective outcomes, I think, will be really useful, also. Dr. Carolyn Lam: Indeed. Manual, in your editorial, you actually discuss some of your own work, which may be the ones that Senthil is actually talking about. What is your view? Dr. Manuel Mayr: Well, I think I'm very excited that beyond fatty acid metabolism and glucose metabolism, ketones have extracted increasing attention. Ketone body metabolism, I think, has long been underappreciated. We still need to understand to what extent it really acts as a fuel and that it can help to overcome the energy deficit that creates heart failure. I think, as mentioned by Svati and Senthil, we need more studies in this area, and of course other trials are ongoing where they're going to measure, for example, the phosphocreatine to ATP ratio by using phosphor-NMR spectroscopy. So we get direct evidence whether there really is an energetic improvement upon SGLT2 inhibition. I think this will be studies to look forward to and to add to the growing literature that metabolism is important as a therapeutic target for heart failure. Dr. Carolyn Lam: Oh, such exciting times. You mentioned the EMPA-VISION trial in your editorial. I think I'm trying to tell everybody, you have to pick up the paper and the editorial. You're going to learn so much. This is so cool. Thank you so, so much all of you for being on this podcast, for sharing your thoughts. I'm sure everyone has learned a lot and enjoyed it just as I have. On behalf of Greg and I, thank you for being here, thank you for joining us today, and don't forget to tune in again next week. Thank you. Dr. Greg Hundley: This program is copyright of the American Heart Association 2022. The opinions expressed by speakers in this podcast are their own and not necessarily those of the editors or of the American Heart Association. For more, please visit ahajournals.org.