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Menopause and age raise our cardiovascular disease risk. Athletes and highly active people also tend to have a higher prevalence of coronary artery calcium and atherosclerotic plaque (though it tends to be the benign kind). But what does that all mean? How can we know what's really going on in those coronary arteries of ours? To find out, host Selene Yeager had a Cleerly-enabled coronary computed tomography angiography (CCTA), which uses AI-enabled software to help characterize coronary plaque composition and cardiovascular disease risk. This week, she sat down with Anita Vadria, MS, PA-C, who is the Director of Medical Science Liaisons and Clinical Education at Cleerly to go over her results, talk about plaque and heart disease risk, and how technology is helping advance our understanding of our personal risk. Anita Vadria, MS, PA-C, is the Director of Medical Science Liaisons and Clinical Education at Cleerly. She is a Board Certified Physician Assistant with a focus in Cardiology. She received her undergraduate degree in Molecular and Cell Biology and received her Masters in Physician Assistant Studies from Western University of Health Sciences in Los Angeles, CA.ResourcesImpact of atherosclerosis imaging-quantitative computed tomography on diagnostic certainty, downstream testing, coronary revascularization, and medical therapy: the CERTAIN study, hereAtherosclerosis Imaging Quantitative Computed Tomography (AI‐QCT) to guide referral to invasive coronary angiography in the randomized controlled CONSERVE trial, hereCoronary Artery Calcification Among Endurance Athletes “Hearts of Stone”, herePhysical Activity and Progression of Coronary Artery Calcification in Men and Women, hereMost heart attack patients' cholesterol levels did not indicate cardiac risk, here Lipid levels in patients hospitalized with coronary artery disease: an analysis of 136,905 hospitalizations in Get With The Guidelines, here2010 ACCF/AHA Guideline for Assessment of Cardiovascular Risk in Asymptomatic AdultsA Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, hereHeart attacks with no obvious risk factors on the rise, hereSubscribe to the Feisty 40+ newsletter: https://feistymedia.ac-page.com/feisty-40-sign-up-page Follow Us on Instagram:Feisty Menopause: @feistymenopause Feisty Media: @feisty_media Selene: @fitchick3 Hit Play Not Pause Facebook Group: https://www.facebook.com/groups/807943973376099 Join Level Up - Our Community for Active Women Navigating the Menopause Transition:Join:...
In this podcast, Bahram Mohajer, MD, MPH, explores the study by Park et al. on the use of AI models to automate the evaluation for coronary artery calcification on low-dose lung cancer screening CT scans, as well as the correlation of AI findings with major adverse cardiovascular events. ARTICLE TITLE - Coronary Artery Calcification on Low-Dose Lung Cancer Screening CT in South Korea: Visual and Artificial Intelligence-Based Assessment and Association with Cardiovascular Events
What are the racial inequities in access to opioids among older patients dying of cancer? Find out this and more in today's PVRoundup podcast.
Where are the biggest cardiovascular benefits for your patients with type 2 diabetes? Host Dr Silvio Inzucchi and cardiologist Dr Mikhail Kosiborod reveal winning strategies — for managing much more than just type 2 diabetes. Relevant disclosures can be found with the episode show notes on Medscape.com (https://www.medscape.com/viewarticle/963270). The topics and discussions are planned, produced, and reviewed independently of our advertiser. This podcast is intended only for US healthcare professionals. Resources New ACC Guidance on CVD Risk Reduction in Diabetes https://www.medscape.com/viewarticle/935218 Type 2 Diabetes in Adults: Management https://www.nice.org.uk/guidance/ng28/chapter/Recommendations#blood-glucose-management Type 2 Diabetes and Causes of Sudden Cardiac Death: A Systematic Review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525691/ Cardiometabolic Medicine – the US Perspective on a New Subspecialty https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7410029/pdf/xce-9-070.pdf Antidiabetics, Glucagon-like Peptide-1 Agonists https://reference.medscape.com/drugs/antidiabetics-glucagon-like-peptide-1-agonists Antidiabetics, SGLT2 Inhibitors https://reference.medscape.com/drugs/antidiabetics-sglt2-inhibitors Dulaglutide and Cardiovascular Outcomes in Type 2 Diabetes (REWIND): A Double-Blind, Randomised Placebo-Controlled Trial https://pubmed.ncbi.nlm.nih.gov/31189511/ Mechanistic Insights Regarding the Role of SGLT2 Inhibitors and GLP1 Agonist Drugs on Cardiovascular Disease in Diabetes https://pubmed.ncbi.nlm.nih.gov/31381891/ SGLT2 Inhibitors for Primary and Secondary Prevention of Cardiovascular and Renal Outcomes in Type 2 Diabetes: A Systematic Review and Meta-analysis of Cardiovascular Outcome Trials https://pubmed.ncbi.nlm.nih.gov/30424892/ Empagliflozin in Patients With Heart Failure, Reduced Ejection Fraction, and Volume Overload: EMPEROR-Reduced Trial https://pubmed.ncbi.nlm.nih.gov/33736819/ Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes https://www.nejm.org/doi/full/10.1056/nejmoa1812389 CV Protection in the EMPA-REG OUTCOME Trial: A "Thrifty Substrate" Hypothesis https://diabetesjournals.org/care/article/39/7/1108/37341/CV-Protection-in-the-EMPA-REG-OUTCOME-Trial-A Worldwide Inertia to the Use of Cardiorenal Protective Glucose-Lowering Drugs (SGLT2i and GLP-1 RA) in High-Risk Patients with Type 2 Diabetes https://cardiab.biomedcentral.com/articles/10.1186/s12933-020-01154-w Albiglutide and Cardiovascular Outcomes in Patients With Type 2 Diabetes and Cardiovascular Disease (Harmony Outcomes): A Double-Blind, Randomised Placebo-Controlled Trial https://pubmed.ncbi.nlm.nih.gov/30291013/ High-Sensitivity C-Reactive Protein https://emedicine.medscape.com/article/2094831-overview#:~:text=hs%2DCRP%20is%20an%20important,predicts%20mortality%20and%20cardiac%20complications. Optimal Use of SGLT2 Inhibitors and GLP-1 Agonists: 5 Things to Know https://www.medscape.com/viewarticle/960356 Cardiovascular and Renal Outcomes with Efpeglenatide in Type 2 Diabetes https://pubmed.ncbi.nlm.nih.gov/34215025/ Coronary Artery Calcification on CT Scanning https://emedicine.medscape.com/article/352189-overview
Commentary by Dr. Valentin Fuster
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In this week's Q&A episode, Dr. Rogers answers YOUR questions! 1. I am a 37 year old male that is very active. I would like to know if there is a specific vitamin regimen for my age group or is it just keep taking Vitamin D, Vitamin C, and Zinc? 2. Why should I take Vitamin D with K over Vitamin D3? 3. I am a male in my mid-70s, in good overall health but have a Coronary Artery Calcification score of 387. I have taken an 81mg aspirin for ~35 years along with a handful of the vitamins that many suggest (B complex, C, D, E, K, CoQ10, magnesium, etc.). You recently reinforced by reason in that a baby aspirin is good to reduce risk of Colon Cancer. I have read that nano-curcumin is good for heart and artery health. A recent newsletter from Dr. Blaylock recommends 250 mg 3x per day 20 minutes per day. I have also read that since both aspirin and Curcumin are potentially mild blood thinners they should not be used at the same time. If the 81 mg aspirin and curcumin should not be taken at the same time, which one seems most important for overall health. Would it be reasonable to take them on alternate days? 4. I recently got my Cleveland Heart Panel results and I am concerned about high ferritin and iron levels for no apparent reason (no massive supplementation). My ferritin was 158, Iron was 161, TIBC was 402 and %Transferrin Sat was 40. I have been iron deficient (under 40 ng/ML) my whole life mainly due to eating habits (vegan and vegetarian at times). What can cause this spike (up over 100 points in one year) and am I at risk for iron overload and damaging my organs? What did you think of this episode of the podcast? Let us know by leaving a review! Connect with Performance Medicine! Sign up for our weekly newsletter: https://performancemedicine.net/doctors-note-sign-up/ Facebook: @PMedicine Instagram: @PerformancemedicineTN YouTube: Performance Medicine Audio
David has a PhD in organic chemistry and spent 4 years in the pharmaceutical industry, developing drugs for cardiovascular disease and cancer. Inspired by the placebo effect, he left the industry to write books and educate people in how they can harness their mind and emotions to improve their health. He is now author of 10 books, including, ‘The Little Book of Kindness', ‘How Your Mind Can Heal Your Body', ‘I Heart Me' and the Amazon bestseller, ‘The Five Side Effects of Kindness'. David is an advocate for kindness and is working passionately to help inspire a kinder world.On this podcast we explore the placebo effect and what this tells us about the power of the mind on the body. We discuss how health professionals can really use this knowledge to maximise the effects of the medications we prescribe. And the importance of empathy and kindness and the evidence that links cardiovascular disease and the quality of our relationships. You can connect with Dr David Hamilton on instagram @davidrhamiltonphd or on his website drdavidhamilton.com. There are links to all his books here - which I would HIGHLY recommend!References: Placebo cream on the hand:F. Benedetti, et al,'Somatotopic Activation of Opioid Systems by Target-Directed Expectations of Analgesia', The Journal of Neuroscience, 1999, 19(9), 3639-3648.Empathy on the immune system (2 refs):D. P. Rakel, et al, 'Perception of Empathy in the Therapeutic Encounter: Effects on the common cold', Patient Education and Counselling, 2011, 85, 390-397B. M. Craig and M.Niu, 'Practitioner Empathy and the Duration of the Common Cold', Family Medicine, 2009, 41(7), 494-501Marriage experience - "Hard Marriage, Hard Heart":T. W. Smith, et al, 'Marital Conflict Behaviour and Coronary Artery Calcification', Paper presented at the American Psychosomatic Society's 64th annual meeting, Denver, CO, 3 March 2006.J. K. Kiecolt-Glaser, et al, 'Hostile Marital Interactions, pro-inflammatory Cytokine Production and Would Healing', Archives of General Psychiatry, 2005, 62, 1377-1384Effect of Writing Therapy. There's quite a few individual studies, but they're all collected together in the following excellent book by one of the main researchers in the field:James W.Pennebaker and John F. Evans, "Expressive Writing: Words that heal", (2014), Idyll Arbour, Inc.
Talk to a Dr. Berg Keto Consultant today and get the help you need on your journey (free consultation). Call 1-540-299-1556 with your questions about Keto, Intermittent Fasting, or the use of Dr. Berg products. Consultants are available Monday through Friday from 8 AM to 10 PM EST. Saturday & Sunday from 9 AM to 6 PM EST. USA Only. Get Dr. Berg's Veggie Solution today! • Flavored (Sweetened) - https://shop.drberg.com/veggie-solution-flavored-sweetened?utm_source=Podcast&utm_medium=AGM(Anchor) • Plain (Unflavored) - https://shop.drberg.com/veggie-solution-plain?utm_source=Podcast&utm_medium=AGM(Anchor) Take Dr. Berg's Free Keto Mini-Course! In this podcast, Dr. Berg talks about the 11 warning signs that you don't want to ignore. The most important thing to do is to focus on bulletproofing yourself by eating healthy and being active so you will never have any of these symptoms at all. 1. Left Arm Pain - This could be a heart problem or it means the heart is going into cramp. 2. Chest Pain - It could also be a heart problem or a blocked coronary artery. One of the best test for the heart is CAC or Coronary Artery Calcification test. 3. Slurred Speech - This could mean that you are having a stroke or a blood clot that is sludge into somewhere in the brain that stopping the circulation where the speech centers could be affected. 4. Blood (Coughing) - It is a very bad indicator of a deep problem. 5. One side of the body (not working) - This could also be a symptom of a stroke and needs to be checked out as fast as you can. 6. Rapid weight loss (without diet) - This could potentially be cancer. 7. Vomiting This can mean a lot of things like from something you just ate, or when you have kidney stones, some type of obstruction, usually related to foods. 8. Leg swelling (left) - It can be related to the heart. 9. Growing rash 10. Unresolved pain - Find out through various test and see where the pain is coming from. 11. Swollen Glands (Persistent) Dr. Eric Berg DC Bio: Dr. Berg, 51 years of age is a chiropractor who specializes in weight loss through nutritional & natural methods. His private practice is located in Alexandria, Virginia. His clients include senior officials in the U.S. government & the Justice Department, ambassadors, medical doctors, high-level executives of prominent corporations, scientists, engineers, professors, and other clients from all walks of life. He is the author of The 7 Principles of Fat Burning. FACEBOOK: fb.me/DrEricBerg?utm_source=Podcast&utm_medium=Anchor TWITTER: http://twitter.com/DrBergDC?utm_source=Podcast&utm_medium=Post&utm_campaign=Daily%20Post YOUTUBE: http://www.youtube.com/user/drericberg123?utm_source=Podcast&utm_medium=Anchor DR. BERG'S SHOP: https://shop.drberg.com/?utm_source=Podcast&utm_medium=Anchor MESSENGER: https://www.messenger.com/t/drericberg?utm_source=Podcast&utm_medium=Anchor
Talk to a Dr. Berg Keto Consultant today and get the help you need on your journey (free consultation). Call 1-540-299-1556 with your questions about Keto, Intermittent Fasting, or the use of Dr. Berg products. Consultants are available Monday through Friday from 8 AM to 10 PM EST. Saturday & Sunday from 9 AM to 6 PM EST. USA Only. Get Dr. Berg's Veggie Solution today! • Flavored (Sweetened) - https://shop.drberg.com/veggie-solution-flavored-sweetened?utm_source=Podcast&utm_medium=AGM(Anchor) • Plain (Unflavored) - https://shop.drberg.com/veggie-solution-plain?utm_source=Podcast&utm_medium=AGM(Anchor) Take Dr. Berg's Free Keto Mini-Course! In this podcast, Dr. Berg talks about vitamin D and calcium. One of the side effects of too much vitamin D or hypervitaminosis D is high levels of calcium in the blood that could potentially lead to calcification of the arteries. Vitamin D3 & K2: https://shop.drberg.com/d3-k2-vitamin-regular?utm_source=Podcast&utm_medium=Post DATA: https://academic.oup.com/endo/article... Dr. Eric Berg DC Bio: Dr. Berg, 51 years of age is a chiropractor who specializes in weight loss through nutritional & natural methods. His private practice is located in Alexandria, Virginia. His clients include senior officials in the U.S. government & the Justice Department, ambassadors, medical doctors, high-level executives of prominent corporations, scientists, engineers, professors, and other clients from all walks of life. He is the author of The 7 Principles of Fat Burning. FACEBOOK: fb.me/DrEricBerg?utm_source=Podcast&utm_medium=Anchor TWITTER: http://twitter.com/DrBergDC?utm_source=Podcast&utm_medium=Post&utm_campaign=Daily%20Post YOUTUBE: http://www.youtube.com/user/drericberg123?utm_source=Podcast&utm_medium=Anchor DR. BERG'S SHOP: https://shop.drberg.com/?utm_source=Podcast&utm_medium=Anchor MESSENGER: https://www.messenger.com/t/drericberg?utm_source=Podcast&utm_medium=Anchor DR. BERG'S VIDEO BLOG: https://www.drberg.com/blog?utm_source=Podcast&utm_medium=Anchor
Joshua Gaines shares his story of reversing decades of Crohn's Disease. For complete show notes, visit http://youcuredwhat.com/podcast/joshua[2:00] In 1991, at 29 years old, Joshua was diagnosed with Crohn’s Disease. Josh’s medical providers indicated that Crohn’s was "your thing that you’re going to have to deal with for the rest of your life." [8:20] There was an expectation that Joshua would require a number of intestinal surgeries over the course of his life. [14:00] Josh had an experience with his son that made him realize food could have an impact on health. [15:30] An integrative physician suggested a no-added-sugar, no-artificial-flavor diet for Josh’s son, who had been diagnosed with Tourette’s, with tics getting progressively worse over time. In six weeks on this diet, his tics went away. [22:00] In February 2013, Joshua adopted a gluten-free diet. 80% of his Crohn’s symptoms went away, but scans still showed Crohn’s activity and gallbladder issues. [25:50] In 2017, Joshua started on the ketogenic diet. He describes the foods he ate. [30:15] Joshua describes the differences he began noticing from the ketogenic diet. His symptoms were 90-plus percent gone. [32:40] He mentions that he had to find these helpful dietary strategies on his own; he did not get help from the doctors he went to. [34:10] He describes that prior to the ketogenic diet, he had tried medications (Humira, for example) without benefit. [36:10] Based on online research he had done, Joshua decided to try a carnivore diet. [36:50] For 14.5 months, Joshua’s diet became 90% beef. He also ate 6 eggs per day and occasionally had other types of meat (seafood or otherwise), and he had coffee. [37:40] Joshua’s blood markers (from his lipid profile) after eating this diet are markedly improved. [39:30] On the carnivore diet, Joshua noticed his longtime cravings for sweets had disappeared. [41:40] Joshua found a great deal of benefits from adopting this carnivorous diet, and he started to help his mother (in her mid-80s) find some of the same benefits. [43:49] Joshua’s most recent scans show NO Crohn’s activity in his large intestine, and he has another scan coming up on his small intestine coming up soon. [46:55] Joshua has a perfect “0” on his Coronary Artery Calcification scan. Having a 0 score is typically indicative of good heart health (especially for a 58-year-old, as Josh is at the time of recording), as it means there is no detected calcification. [50:10] Joshua is now experimenting with adding a small amount of the following foods back to his diet: hard cheese, a few beans, avocados, and vegetables. [53:00] Joshua has nearly perfect digestive health now. No gas, no pain. [53:40] Joshua used to have approximately 5-6 bowel movements per day. The number has gone down and the quality has gone up. [56:10] Joshua’s exercise recovery is greatly improved now on his carnivore diet. [1:01:40] Now that he’s improved his health, what’s one thing Joshua enjoys doing that he couldn’t do before?
Interview with Benjamin D. Levine, author of Association of All-Cause and Cardiovascular Mortality With High Levels of Physical Activity and Concurrent Coronary Artery Calcification
Interview with Benjamin D. Levine, author of Association of All-Cause and Cardiovascular Mortality With High Levels of Physical Activity and Concurrent Coronary Artery Calcification
Today We Finally Get to Talk Healthy Fats Science with Ivor Cummins Also Known As The Fat Emperor From Dublin Ireland: Ivor Cummins BE(Chem) CEng MIEI PMP® completed a Chemical Engineering in 1990. He has since spent over 25 years in corporate technical leadership and management positions, and was shortlisted in 2015 as one of the top 6 of 500 applicants for “Irish Chartered Engineer of the Year”. Ivor’s focus and specialty are leading teams in complex problem-solving scenarios. He has often led worldwide teams with over 60-70 engineers working on major technical issues; the largest of these involved product issues where hundreds of millions of dollars were in the balance. Several years ago, Ivor encountered a complex technical challenge in his personal life. Receiving poor blood test results, he was unable to get solutions via the doctors consulted. He thus embarked on an intense period of biochemical research into the science of human metabolism. Within eight weeks he had resolved and optimized all of his blood test metrics. Also, he had shed over 15Kg of body fat with relative ease. In the following years, he continued his research on the many “root causes” of modern disease, from “cholesterol” through to insulin resistance. In order to help stem the tide of chronic disease in our modern population, he embarked on a personal mission to share the science and solutions. He began this process by giving corporate talks and releasing them on YouTube for the wider audience. He has since become a professional speaker of note, giving many public lectures and chairing interviews with worldwide health experts. Most notably he was invited by the President of the British Association for Cardiovascular Prevention and Rehabilitation (BACPR) to give a keynote talk on heart disease root causes, at their annual conference in London last October. All of Ivor’s public lectures and interviews are available on Ivor's YouTube channel (https://www.youtube.com/channel/UCPn4FsiQP15nudug9FDhluA) , where well over a million views have been recorded to date: His book on chronic disease root causes and resolution strategies (co-authored with Denver doctor Jeffry Gerber MD, FAAFP) was released in the US and Canada in March 2018. It has already received around 150 reviews on Amazon, of which ~97% are 5-stars, check out Eat Rich Live Long on Amazon (https://amzn.to/2C5fjno) ! His blog and other content is available at www.thefatemperor.com (http://www.thefatemperor.com) From early 2018 Ivor has been fully funded by the Irish Heart Disease Awareness charity ( www.IHDA.ie (http://www.IHDA.ie) ). This fulfills their mission in enabling all middle-risk people to access the power of the Coronary Artery Calcification scan (CAC). He has thus ramped up his passion to help the people help themselves – in a journey to health, weight-loss, and longevity. Ivor lives in Dublin, Ireland, with his wife and five children. On This Episode You Will Hear:[spp-timestamp time="00:30"] Introduction [spp-timestamp time="02:51"] What's a stag party and hen party in Ireland. [spp-timestamp time="04:20"] Scott and Ivor connect on chainsaws, farming, and more. Giant gardens, before poisons, pesticides and chemicals and all this other stuff. Ivor only remembered nitrate fertilizer which was spread on the grass. You learn as well did the value of hard work. I mean, we have to work 14 hour days sometimes bringing in that hey. [spp-timestamp time="08:02"] Scott shares his Irish bloodlines plus 23andme DNA analysis. Talking fatty coffee, don't need to call it bulletproof, using Kerrygold Grass Fed Irish Butter. Ivor generally doesn't really eat breakfast anymore but makes a French press or espresso coffee. As it happens, he's not crazy about the butter in the coffee and the little globules. So he puts in heavy cream aka Irish double cream. [spp-timestamp time="10:10"] Ivor didn't want to come across as arrogant
Ivor Cummins is a Biochemical Engineer who in 2012 was disturbed by a set of his own abnormal blood test results. Consultation with multiple doctors yielded little insight into the cause of his elevated cholesterol, ferritin and GGT so he turned to his analytical roots to study the problem. In the process, he evaluated hundreds of scientific papers, ultimately concluding that that flawed hypotheses and a breach of the scientific method have resulted in the current “diabesity” epidemic. Ivor is here today with Dr. Tommy Wood talking on topics related to his well-referenced new book, Eat Rich, Live Long: Mastering the Low-Carb & Keto Spectrum for Weight Loss and Great Health. They also discuss the trouble with polyunsaturated oils, advice on fat loss for the insulin sensitive, and the best test for cardiovascular disease risk (hint: it’s not LDL). If you enjoy this podcast, Ivor is a regular presenter at low-carb/keto events and maintains an active blog and social media presence. Here’s the outline of this interview with Ivor Cummins: [00:00:17] Keto Summit, Dave Feldman. [00:00:48] Boundless Health Podcast with Dr. Bret Scher. [00:01:57] Podcast: The True Root Causes of Cardiovascular Disease, with Dr. Jeffry Gerber. [00:02:15] Book: Eat Rich, Live Long: Mastering the Low-Carb & Keto Spectrum for Weight Loss and Great Health, by Ivor Cummins and Jeffry Gerber, MD. [00:02:29] Videos: here and here. [00:03:20] Insulin, IGF-1, acellular carbs. [00:03:56] Sunlight exposure, 25-OH-D video. [00:04:37] Minerals, Study: DiNicolantonio, James J., James H. O’Keefe, and William Wilson. "Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis." Open Heart 5.1 (2018): e000668. [00:05:28] Gabor Erdosi, Lower Insulin Facebook Group. [00:05:43] Video: Roads to Ruin? from Physicians for Ancestral Health 2017 conference. [00:06:01] Guðmundur Jóhannsson, gut health; Podcast: Foodloose Iceland. [00:07:40] Study: Schwalfenberg, Gerry K., and Stephen J. Genuis. "The importance of magnesium in clinical healthcare." Scientifica 2017 (2017). [00:08:10] Industrial seed oils. [00:09:05] Unilever sells its margarine business. [00:10:17] Studies: Alvheim, Anita Røyneberg, et al. "Dietary Linoleic Acid Elevates the Endocannabinoids 2‐AG and Anandamide and Promotes Weight Gain in Mice Fed a Low Fat Diet." Lipids 49.1 (2014): 59-69. And: Alvheim, Anita R., et al. "Dietary Linoleic Acid Elevates Endogenous 2‐AG and Anandamide and Induces Obesity." Obesity 20.10 (2012): 1984-1994. [00:10:48] Studies: Nanji, Amin A., and Samuel W. French. "Dietary factors and alcoholic cirrhosis." Alcoholism: Clinical and Experimental Research 10.3 (1986): 271-273. And: Kirpich, Irina A., et al. "Alcoholic liver disease: update on the role of dietary fat." Biomolecules 6.1 (2016): 1. [00:12:09] Book: Deep Nutrition: Why Your Genes Need Traditional Food, by Cate Shanahan, M.D. [00:12:45] Studies: 1. Ramsden, Christopher E., et al. "The Sydney Diet Heart Study: a randomised controlled trial of linoleic acid for secondary prevention of coronary heart disease and death." The FASEB Journal 27.1 Supplement (2013): 127-4. 2. Frantz, Ivan D., et al. "Test of effect of lipid lowering by diet on cardiovascular risk. The Minnesota Coronary Survey." Arteriosclerosis, Thrombosis, and Vascular Biology 9.1 (1989): 129-135. 3. Strandberg, Timo E., et al. "Mortality in participants and non-participants of a multifactorial prevention study of cardiovascular diseases: a 28 year follow up of the Helsinki Businessmen Study." Heart 74.4 (1995): 449-454. 4. Rose, G. A., W. B. Thomson, and R. T. Williams. "Corn oil in treatment of ischaemic heart disease." British medical journal 1.5449 (1965): 1531. [00:13:47] Study: Hooper, Lee, et al. "Reduction in saturated fat intake for cardiovascular disease." The Cochrane Library (2015). [00:15:28] Study: Ip, Clement, Christopher A. Carter, and Margot M. Ip. "Requirement of essential fatty acid for mammary tumorigenesis in the rat." Cancer Research 45.5 (1985): 1997-2001. [00:16:28] Study: Pearce, Morton Lee, and Seymour Dayton. "Incidence of cancer in men on a diet high in polyunsaturated fat." The Lancet 297.7697 (1971): 464-467. [00:16:56] Breast milk composition is now almost 50% PUFA. [00:17:50] David Bobbett. [00:19:59] Book structure. [00:20:51] Fat-loss for the insulin sensitive. [00:21:10] Videos: Jeff Gerber interviews Simon Saunders and Marty Kendall. [00:23:03] Ghrelin. [00:24:21] Protein and lean body mass. [00:26:05] Glucagon, mTOR. [00:26:22] Ron Rosedale. [00:26:34] Valter Longo. [00:27:02] IGF-1 U-shaped curve. [00:28:06] Study: Levine, Morgan E., et al. "Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population." Cell metabolism 19.3 (2014): 407-417. [00:28:49] Book: Protein Power: The High-Protein/Low Carbohydrate Way to Lose Weight, Feel Fit, and Boost Your Health - in Just Weeks! By Michael Eades and Mary Dan Eades. [00:30:39] Study: Levine, Morgan E., et al. "Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population." Cell metabolism 19.3 (2014): 407-417. [00:31:06] NHANES. [00:31:18] Study: Cohen, Evan, et al. "Statistical review of US macronutrient consumption data, 1965–2011: Americans have been following dietary guidelines, coincident with the rise in obesity." Nutrition 31.5 (2015): 727-732. [00:32:20] Kitavans. [00:34:05] Hyperlipid and Denise Minger. [00:36:37] Icelandic diets for longevity [00:39:07] Cardiovascular disease. [00:39:35] Basic lipid panel. [00:39:45] Study: Castelli, William P. "Lipids, risk factors and ischaemic heart disease." Atherosclerosis 124 (1996): S1-S9. [00:40:24] Ratios. [00:41:54] Study: Johnson, Kevin M., David A. Dowe, and James A. Brink. "Traditional clinical risk assessment tools do not accurately predict coronary atherosclerotic plaque burden: a CT angiography study." American Journal of Roentgenology 192.1 (2009): 235-243. Commentary: Ware, William R. "The mainstream hypothesis that LDL cholesterol drives atherosclerosis may have been falsified by non-invasive imaging of coronary artery plaque burden and progression." Medical hypotheses 73.4 (2009): 596-600. [00:42:30] Familial Hypercholesterolemia and CVD. [00:43:27] cholesterolcode.com, remnant cholesterol, Plasma Atherogenic Index. [00:44:36] Podcast: Health Outcome-Based Optimal Reference Ranges for Cholesterol [00:46:06] Coronary calcium scan. [00:46:25] Study: Nasir, Khurram, et al. "Interplay of Coronary Artery Calcification and Traditional Risk Factors for the Prediction of All-Cause Mortality in Asymptomatic Individuals Clinical Perspective." Circulation: Cardiovascular Imaging 5.4 (2012): 467-473. [00:47:54] Longitudinal score. [00:49:41] Plaque density. [00:50:11] Interview with Matt Budoff. [00:52:37] Video: Dr. Eades at Low Carb Breckenridge, Agatston score. [00:54:38] The Fat Emperor. [00:54:53] Low-carb Breckenridge 2018. [00:55:10] Ketofest, Keto Con, Low-carb USA, Refind Health. [00:55:45] Widowmaker movie.
On this week's show, we discuss some of the latest research and findings in our News & Views segment. Our stories are about how the soda industry plays politics to advance its agenda, whether salt is good or bad in the human diet, and whether calcium supplements pose a heart-health risk. The Moment of Paleo segment offers ideas about how we can think about areas of our lives, by analogy, based on what we know about whole foods vs. processed foods and supplements. In the After the Bell segment a truly thought-provoking talk about how we create ourselves with our thoughts. Links for this episode:This Episode's Homepage on latestinpaleo.comLatest in Paleo on Facebook — Leave a Comment About this Episode or Post a News LinkThe Latest in Paleo Health News TickerFood & Product RecommendationsThe Paleo Answer - Loren CordainThe End of Dieting - Dr. Joel FuhrmanMore Book & Audiobook RecommendationsSponsorship of National Health Organizations by Two Major Soda Companies - American Journal of Preventive MedicineCoke and Pepsi Give Millions to Public Health, Then Lobby Against It - The New York TimesBig soda is buying off big health orgs to keep profits and Americans fat | Ars TechnicaPepsi gets aggressive on cutting sugar from its drinks - Oct. 17, 2016Sodium Intake and All-Cause Mortality Over 20 Years in the Trials of Hypertension Prevention. - PubMed - NCBIHold the salt this Thanksgiving for a longer life: study | CTV NewsLowering Salt Intake Reduces Mortality, Study Confirms - Renal and Urology NewsMore Research Cites Salt's Potential Health RisksCalcium Intake From Diet and Supplements and the Risk of Coronary Artery Calcification and its Progression Among Older Adults: 10?Year Follow?up of the Multi?Ethnic Study of Atherosclerosis (MESA)Calcium Supplements May Damage the Heart - 10/11/2016Calcium supplements could increase risk of heart disease, new study finds - The Washington PostStudy: Calcium Supplements Actually Increases Risk of Heart Disease - NBC NewsIsaac Lidsky: What reality are you creating for yourself? | TED Talk | TED.com
Commentary by Dr. Valentin Fuster
Coronary heart disease (CHD) is a major public health problem not only in developed but also in developing countries.1 CHD rates in Japan are uniquely low compared to the USA and other developed countries.In a paper in April's Heart, Akira Sekikawa and colleagues from the University of Pittsburgh looked at whether serum concentrations of long chain n-3 polyunsaturated fatty acids (LCn3PUFAs) contribute to the difference in the incidence rate of coronary artery calcification (CAC) between Japanese men in Japan and white men in the USA.Alistair Lindsay asks him what they found.Read the full paper:Long chain n-3 polyunsaturated fatty acids and incidence rate of coronary artery calcification in Japanese men in Japan and white men in the USA: population based prospective cohort study http://goo.gl/rwKUCW
Interview with Jared P. Reis, PhD, author of Association Between Duration of Overall and Abdominal Obesity Beginning in Young Adulthood and Coronary Artery Calcification in Middle Age
Objectives: Pericardial adipose tissue (PAT) is associated with coronary artery plaque accumulation and the incidence of coronary heart disease. We evaluated the possible incremental prognostic value of PAT for future cardiovascular events. Methods: 145 patients (94 males, age 60 10 years) with stable coronary artery disease underwent coronary artery calcification (CAC) scanning in a multislice CT scanner, and the volume of pericardial fat was measured. Mean observation time was 5.4 years. Results: 34 patients experienced a severe cardiac event. They had a significantly higher CAC score (1,708 +/- 2,269 vs. 538 +/- 1,150, p < 0.01), and the CAC score was highly correlated with the relative risk of a future cardiac event: 2.4 (1.8-3.7; p = 0.01) for scores > 400, 3.5 (1.9-5.4; p = 0.007) for scores > 800 and 5.9 (3.7-7.8; p = 0.005) for scores > 1,600. When additionally a PAT volume > 200 cm(3) was determined, there was a significant increase in the event rate and relative risk. We calculated a relative risk of 2.9 (1.9-4.2; p = 0.01) for scores > 400, 4.0 (2.1-5.0; p = 0.006) for scores > 800 and 7.1 (4.1-10.2; p = 0.005) for scores > 1,600. Conclusions:The additional determination of PAT increases the predictive power of CAC for future cardiovascular events. PAT might therefore be used as a further parameter for risk stratification. Copyright (C) 2012 S. Karger AG, Basel