Podcasts about noxa

Soutenez le podcast et choisissez votre contrepartie originale sur https://fr.tipeee.com/rencontres-surnaturelles-juliette-dargand Aujourd'hui, on se retrouve pour un épisode un peu spécial. Nous allons tout d'abord rencontrer Nils et Philippe, les deux fondateurs du Frissons Festival, le premier festival littéraire dédié à l'horreur et au paranormal qui se tiendra à Reims les 26 et 27 octobre 2024. Ils vont nous expliquer comment ce festival hors norme va se dérouler et revenir sur la première édition et son succès imprévisible. Pour tout savoir sur le festival, voici quelques liens : https://www.frissons-festival.com/ https://www.instagram.com/frissons_festival/ Ensuite, mon amie Noxa, chroniqueuse littéraire passionnée et auteur, nous fera l'honneur de nous partager trois recommandations de livres : Simetierre de Stephen King, Avechttps://www.livredepoche.com/livre/avec-tes-yeux-9782253195887 tes yeux de Cédric Sire et Les sorcières du phare de C. J. Cooke. Voici quelques liens pour aller plus loin : Les pages de Noxa :  https://www.instagram.com/hexlibris_noxa/ https://www.twitch.tv/noxanyma Les livres recommandés : Simetierre - Stephen King : https://www.cultura.com/p-simetierre-9782226024824.html Avec tes yeux - Cédric Sire : https://www.livredepoche.com/livre/avec-tes-yeux-9782253195887 Les sorcières du phare - C.J. Cooke : https://www.fnac.com/a19308347/C-J-Cooke-Les-Sorcieres-du-phare Enfin, nous terminons cet entretien avec un tirage tarot qui vous donnera les tendances de votre été. La tendance avec la carte du soleil est au repos, au bien-être et au ressourcement. Membre du Label Tout Savoir. Régies publicitaires : PodK et Ketil Media Soutenez-nous sur Tipeee !

Social media heeft ons leven helemaal overgenomen. We kunnen niet meer zonder. Voor ons begon het ooit met MSN en later kwamen Netlog, Noxa en natuurlijk Facebook en Instagram. Tegenwoordig komt er elke drie maanden wel een platform bij, maar wat daarop gebeurt is vooral heerlijk voer voor discussie. Moeders met reactiestickers, schreeuwende zangers op TikTok,  veel #wanderlust en influencers die smeerkaas promoten. Wij worden tot nader order niet gesponsord, dus we kunnen (bijna) alles zeggen wat we willen. Het zijn trouwens écht goeie drinkbussen.

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El nombre de María Inés Krimer, quien nació en Paraná, Entre Ríos, en 1951, está asociado al policial y a los premios. Sus novelas como Sangre Kosher, Cupo, Noxa o Sangre Fashion se inscriben en la tradición del género desde hace tiempo, siempre del lado de la literatura que se recomienda boca a boca y con la particularidad de incluir en sus tramas momentos políticos, sociales o del mundo de las ideas, en una forma de participación de la autora en la discusión pública. Su última novela, Papeles de Ana, publicada por Obloshka, no es una novela de género, como no lo fue La hija de Singer, su premiada novela de 2002, con la que en algún sentido comulgan. Esta vez la historia es contada a través de un relato dividido en tres partes, dos de las cuales trabajan el género epistolar y la otra es una narración a través de postales. Ana nació en Entre Ríos, quiere ser escritora. Conocemos su historia a través de sus cartas pero también a través de cartas de los otros. Hay un juego de tiempos entre la década del 60 y el presente, en el hoy, una investigadora estadounidense la busca, quiere contactarla y no consigue hacerlo y para eso le escribe a diversas personas que la conocieron. La vida de pueblo, la llegada a la gran ciudad, los viajes a Moscú en el marco de las actividades de la juventud comunista, los celos familiares en una familia judía, la rivalidad entre los pudientes y los que necesitan asistencia, el humor, la malicia, los primeros amores, las primeras relaciones sexuales, el lugar de las mujeres en la literatura décadas atrás, de todo esto trata Papeles de Ana, una novela íntima y social, deliciosamente escrita, que devuelve el escenario de un tiempo en el que se producía mucha literatura pero que no suele ser tan frecuentado por la literatura de hoy. En la sección  Libros que sí Hinde recomendó “¿Cómo fue que todo salió bien?” y “El dios salvaje”, ambos de Al Alvarez, y “Virginia Woolf. Escenas de una vida: matrimonio, amigos y escritura” y en El Extranjero comentó sobre la publicación de “The woman from Uruguay” (La uruguaya) de Pedro Mairal en Estados Unidos. En Mesita de luz, el director de Fondo de Cultura Económica en Argentina Gastón Levin nos contó que libros está leyendo y una sección especial de  En voz alta recordamos a Tamara Kamenszain con la lectura de Eduardo Aliverti de un poema del libro “Solos y solas” y  también Hinde la recordó con la lectura de un poema de “Chicas en tiempo suspendido”, su último libro publicado por Eterna Cadencia.    

Effects of saffron extract on sleep quality: a randomized, double-blind clinical trial   Catholic University Louvain (Belgium). May 10. 2021 According to news reporting from Louvain la Neuve, Belgium, research stated, “A saffron extract has been found to be effective in the context of depression and anxiety, but its effect on sleep quality has not been investigating yet using objective approaches.” The news reporters obtained a quote from the research from Catholic University Louvain (UCLouvain): “For this purpose, a randomized double-blind controlled study was conducted in subjects presenting mild to moderate sleep disorder associated with anxiety. Sixty-six subjects were randomized and supplemented with a placebo (maltodextrin) or a saffron extract (15.5 mg per day) for 6 weeks. Actigraphy was used to collect objective data related to sleep quality at baseline, at the middle and at the end of the intervention. Sleep quality was also assessed by completion of the LSEQ and PSQI questionnaires and quality of life by completion of the SF-36 questionnaire. Six weeks of saffron supplementation led to an increased time in bed assessed by actigraphy, to an improved ease of getting to sleep evaluated by the LSEQ questionnaire and to an improved sleep quality, sleep latency, sleep duration, and global scores evaluated by the PSQI questionnaire, whereas those parameters were not modified by the placebo.” According to the news editors, the research concluded: “In conclusion, those results suggest that a saffron extract could be a natural and safe nutritional strategy to improve sleep duration and quality.”         New evidence links gut bacteria and neurodegenerative conditions University of Florida, May 6, 2021 Neurodegenerative diseases such as Alzheimer's, Parkinson's and ALS affect millions of adults, but scientists still do not know what causes these diseases, which poses a significant roadblock to developing treatments or preventative measures. Recent research suggests that people with these conditions exhibit changes in the bacterial composition of their digestive tract. However, given the vast diversity of microbes found in the human body, identifying which bacteria may be associated with neurodegeneration is like finding a needle in a haystack. Seeking that proverbial needle, scientists at the University of Florida are looking in an unexpected place: the digestive tract of a tiny, translucent worm called Caenorhabditis elegans. New research published in PLOS Pathogens establishes, for the first time, a link between specific bacteria species and physical manifestations of neurodegenerative diseases. The study's lead author is Alyssa Walker, a microbiology and cell science doctoral candidate in the UF/IFAS College of Agricultural and Life Sciences. "Looking at the microbiome is a relatively new approach to investigating what causes neurodegenerative diseases. In this study, we were able to show that specific species of bacteria play a role in the development of these conditions," said Daniel Czyz, Walker's dissertation advisor. Czyz is the senior author of the study and an assistant professor in the UF/IFAS department of microbiology and cell science. "We also showed that some other bacteria produce compounds that counteract these 'bad' bacteria. Recent studies have shown that patients with Parkinson's and Alzheimer's disease are deficient in these 'good' bacteria, so our findings may help explain that connection and open up an area of future study," he added. All neurodegenerative diseases can be traced to problems with the way proteins are handled in the body. If proteins are misfolded, they build up and accumulate in tissues. These protein aggregates, as scientists call them, interfere with cell functioning and lead to neurodegenerative disorders. Czyz and his co-authors wanted to know if introducing certain bacteria into the C. elegans worms would be followed by protein aggregation in the worms' tissues. "That is, in fact, what we observed. We have a way of marking the aggregates so they glow green under the microscope. We saw that worms colonized by certain bacteria species were lit up with aggregates that were toxic to tissues, while those colonized by the control bacteria were not," Czyz said. "This occurred not just in the intestinal tissues, where the bacteria are, but all over the worms' bodies, in their muscles, nerves and even reproductive organs." Surprisingly, the offspring of affected worms also showed increased protein aggregation—even though these offspring never encountered the bacteria originally associated with the condition. "This is very interesting because it suggests that these bacteria generate some sort of a signal that can be passed along to the next generation," Czyz said. Worms colonized by the "bad" bacteria also lost mobility, a common symptom of neurodegenerative diseases. "A healthy worm moves around by rolling and thrashing. When you pick up a healthy worm, it will roll off the pick, a simple device that we use to handle these tiny animals. But worms with the bad bacteria couldn't do that because of the appearance of toxic protein aggregates," explained Walker, who developed this assessment method. "You could compare the pick to an obstacle course: just as a person with a neurodegenerative disease will have trouble getting across, the same is true with these worms, just at a much smaller scale," Czyz added. Fun fact: Human eyebrow hairs or eyelashes make for very good picks. "The worms are very delicate, so you need a tool that won't damage them. They are also transparent and have a simple body plan. Studies like ours are possible because these worms normally feed on bacteria," Czyz said. "The worms are only one millimeter long, and they each have exactly 959 cells," Czyz said. "But in many ways, they are a lot like us humans—they have intestines and muscles and nerves, but instead of being composed of billions of cells, each organ is just a handful of cells. They are like living test tubes. Their small size allows us to do experiments in a much more controlled way and answer important questions we can apply in future experiments with higher organisms and, eventually, people." Currently the Czyz lab is testing hundreds of strains of bacteria found in the human gut to see how they affect protein aggregation in C. elegans. The group is also investigating how bacteria associated with neurodegeneration cause protein misfolding at the molecular level. Czyz is also interested in possible connections between antibiotic-resistant bacteriaand protein misfolding. "Almost all of the bacteria we found associated with protein misfolding are also associated with antibiotic-resistant infections in people. However, it will take many more years of research before we can understand what, if any, connection there is between antibiotic resistance and neurodegenerative diseases," Czyz said.   Meditative practice and spiritual wellbeing may preserve cognitive function in aging Alzheimer's Research and Prevention Foundation &Thomas Jefferson University, May 11, 2021 It is projected that up to 152 million people worldwide will be living with Alzheimer's disease (AD) by 2050. To date there are no drugs that have a substantial positive impact on either the prevention or reversal of cognitive decline. A growing body of evidence finds that targeting lifestyle and vascular risk factors have a beneficial effect on overall cognitive performance. A new review in the Journal of Alzheimer's Disease, published by IOS Press, examines research that finds spiritual fitness, a new concept in medicine that centers on psychological and spiritual wellbeing, and Kirtan Kriya, a simple 12-minute meditative practice, may reduce multiple risk factors for AD. "The key point of this review is that making a commitment to a brain longevity lifestyle, including spiritual fitness, is a critically important way for aging Alzheimer's disease free," explain authors Dharma Singh Khalsa, MD, Alzheimer's Research and Prevention Foundation, Tucson, AZ, USA, and Andrew B. Newberg, MD, Department of Integrative Medicine and Nutritional Sciences, Department of Radiology, Marcus Institute of Integrative Health, Thomas Jefferson University, Philadelphia, PA, USA. "We hope this article will inspire scientists, clinicians, and patients to embrace this new concept of spiritual fitness and make it a part of every multidomain program for the prevention of cognitive disability." Research reveals that religious and spiritual involvement can preserve cognitive function as we age. The authors observe that today, spirituality is often experienced outside the context of an organized religion and may be part of every religion or separate to it. Spiritual fitness is a new dimension in AD prevention, interweaving basic, psychological and spiritual wellbeing. The authors discuss the research on how these factors affect brain function and cognition. For example, psychological wellbeing may reduce inflammation, cardiovascular disease, and disability. Significantly, individuals who have a high score on a "purpose in life" (PIL) measure, a component of psychological wellbeing, were 2.4 times more likely to remain free of AD than individuals with low PIL. In another study, participants who reported higher levels of PIL exhibited better cognitive function, and further, PIL protected those with already existing pathological conditions, thus slowing their decline. Stress and stress management are under-discussed topics in AD prevention, yet the authors point out that there is ample evidence that physical, psychological, and emotional effects of stress may elevate AD risk. Kirtan Kriya (KK) is a 12-minute singing meditation that involves four sounds, breathing, and repetitive finger movements. It has multiple documented effects on stress, such as improving sleep, decreasing depression, and increasing wellbeing. It has also been found to increase blood flow to areas of the brain involved in cognition and emotional regulation and increases gray matter volume and decreases ventricular size in long-term practitioners, which may slow brain aging. Research in healthy individuals, caregivers, and those with cognitive decline found that the practice improves cognition, slows memory loss, and improves mood. The overall relationship between spiritual fitness and a person's complete physical and mental health is a topic of investigation in the emerging field of study called neurotheology. Early work has focused on the development of models regarding which brain areas are affected through spiritual practices such as meditation or prayer. Over the last 20 years, there has been an extensive growth in neuroimaging and other physiological studies evaluating the effect of meditation, spiritual practices, and mystical experiences. A neuroimaging study of KK found long term brain effects, during meditation and afterwards. Neurotheological studies can help understanding of how a practice such as KK can lead to more permanent effects in brain function that support spiritual fitness, according to Dr. Khalsa and Dr. Newberg. "Mitigating the extensive negative biochemical effects of stress with meditation practices, in tandem with the creation of heightened levels of spiritual fitness, may help lower the risk of AD. Small shifts in one's daily routine can make all the difference in AD prevention," Dr. Khalsa and Dr. Newberg conclude. "We are optimistic this article will inspire future research on the topic of spiritual fitness and AD."   Type 2 Diabetes: Sitting can Cause Problems with Blood Sugar Levels, So Get Up and Move Glasgow Caledonian University, May 11, 2021   Many people spend large portions of their day sitting, which can cause a range of health problems. But many may not realise that sitting too much can also worsen certain health conditions, such as type 2 diabetes. Research shows that spending too much time sitting can cause problems with blood sugar levels – making it even more important for those with type 2 diabetes to get plenty of physical activity into their day. Type 2 diabetes causes the level of sugar (glucose) in the blood to become too high. For someone with diabetes, high sugar levels in the blood can cause serious damage to your body, including the heart, kidneys, eyes, feet and nerves. Controlling blood sugar levels is important for avoiding the risk of serious health problems. Lifestyle changes, such as adjusting diet and physical activity, and diabetes medications, such as metformin or gliptin, are used to lower blood sugar levels. Yet following recommended diets and taking diabetes medications aren’t always effective at controlling blood sugar levels, as our research found. This shows us there’s a need to re-think diabetes care and management. As type 2 diabetes can be different for everyone, how well a person controls their blood sugar levels can be influenced by different factors, such as age, gender, activity levels, diet and weight. This makes it important to target new, modifiable lifestyle factors – such as how much time is spent sitting. Research we’ve done, which looked at 37 adults with type 2 diabetes, found that over two weeks, prolonged sitting was associated with high blood sugar levels. But we also found that when people stood up or walked around between periods of sitting, they had lower blood sugar levels. Other studies have also had similar results. Our research has also shown that sitting less or breaking up periods of sitting with bouts of activity could be a simple way to manage blood sugar levels – including high sugar levels before and after breakfast, which is a common problem for people with type 2 diabetes. We found that simply walking more often could be beneficial to blood sugar control throughout the day. In fact, walking every 15 minutes for as little as three minutes each time at a person’s usual pace could be enough to help them control their blood sugar – and could even be as effective as standard diabetes medications. Other research has shown that keeping bouts of sitting shorter than 15 minutes is better for blood sugar levels.   The reason walking – and other types of exercise – are so good for regulating blood sugar is because they make the body’s muscles work. Movement causes muscles to contract, which subsequently starts the mechanisms that allow the sugar in the blood to enter cells and fuel the body. This reduces blood sugar levels as a result. With many people continuing to spend large portions of their days sitting while working from home, it’s important for people with type 2 diabetes to stand and walk often. Of course, that is sometimes easier said than done. But even small changes in sitting patterns throughout the day may be beneficial to a person’s blood sugar control. For example, going to the kitchen to get water or make tea can be a great opportunity to walk around for a few minutes. Even standing or walking while taking calls or during meetings can be a good idea. It’s still important for people with type 2 diabetes to follow the advice of their doctor and stick to any special diets or take any medications they’ve been prescribed. But adding extra movement into their day will not only improve blood sugar control, it may also improve other aspects of health – including heart health and bone density.     Grapeseed compound has senolytic activity   Chinese Academy of Sciences, May 10, 2021 According to news reporting based on a preprint abstract, our journalists obtained the following quote sourced from biorxiv.org: “Aging causes functional decline of multiple organs and increases the risk of age-related pathologies. “In advanced lives, accumulation of senescent cells, which develop the senescence-associated secretory phenotype (SASP), promotes chronic inflammation and causes diverse conditions. “Here we report the frontline outcome of screening a natural product library with human primary stromal cells as an experimental model. Multiple candidate compounds were assayed, and grape seed extract (GSE) was selected for further investigation due to its leading capacity in targeting senescent cells. “We found procyanidin C1 (PCC1), a polyphenolic component, plays a critical role in mediating the antiaging effects of GSE. PCC1 blocks the SASP expression when used at low concentrations. Importantly, it selectively kills senescent cells upon application at higher concentrations, mainly by enhancing production of reactive oxygen species (ROS) and disturbing mitochondrial membrane potential, processes accompanied by upregulation of Bcl-2 family pro-apoptotic factors Puma and Noxa in senescent cells. PCC1 depletes senescent cells in treatment-damaged tumor microenvironment (TME) and enhances therapeutic efficacy when combined with chemotherapy in preclinical assays. Intermittent administration of PCC1 to both senescent cell-implanted mice and naturally aged animals alleviated physical dysfunction and prolonged post-treatment survival, thus providing substantial benefits in late life stage. Together, our study identifies PCC1 as a distinct natural senolytic agent, which may be exploited to delay aging and control age-related pathologies in future medicine.” This preprint has not been peer-reviewed.         Team Links Leaky Epithelial Barriers to 2 Billion Chronic Diseases University of Zurich, May 7, 2021 Epithelial cells form the covering of most internal and external surfaces of the human body. This protective layer acts as a defense against invaders—including bacteria, viruses, environmental toxins, pollutants and allergens. If the skin and mucosal barriers are damaged or leaky, foreign agents such as bacteria can enter into the tissue and cause local, often chronic inflammation with both direct and indirect consequences. “The epithelial barrier hypothesis proposes that damages to the epithelial barrier are responsible for up to two billion chronic, non-infectious diseases,” says Cezmi Akdis, director of the Swiss Institute of Allergy and Asthma Research (SIAF), which is associated with the University of Zurich. In the past 20 years, researchers at the SIAF alone have published more than 60 articles on how various substances damage the epithelial cells of a number of organs. The epithelial barrier hypothesis provides an explanation as to why allergies and autoimmune diseases have been increasing for decades—they are linked to industrialization, urbanization, and westernized lifestyle. Today many people are exposed to a wide range of toxins, such as ozone, nanoparticles, microplastics, household cleaning agents, pesticides, enzymes, emulsifiers, fine dust, exhaust fumes, cigarette smoke, and countless chemicals in the air, food, and water. “Next to global warming and viral pandemics such as COVID-19, these harmful substances represent one of the greatest threats to humankind,” Akdis says. Local epithelial damage to the skin and mucosal barriers lead to allergic conditions, inflammatory bowel disorders, and celiac disease. But disruptions to the epithelial barrier can also be linked to many other diseases that are characterized by changes in the microbiome. Either the immune system erroneously attacks “good” bacteria in healthy bodies or it targets pathogenic—i.e., “bad”—invaders. In the gut, leaky epithelial barriers and microbial imbalance contribute to the onset or development of chronic autoimmune and metabolic diseases such as diabetes, obesity, rheumatoid arthritis, multiple sclerosis, or ankylosing spondylitis. Moreover, defective epithelial barriers have also been linked to neurodegenerative and psychiatric diseases such as Parkinson’s disease, Alzheimer’s disease, autism spectrum disorders, and chronic depression, which may be triggered or aggravated by distant inflammatory responses and changes in the gut’s microbiome. “There is a great need to continue research into the epithelial barrier to advance our understanding of molecular mechanisms and develop new approaches for prevention, early intervention and therapy,” says Akdis. Novel therapeutic approaches could focus on strengthening tissue-specific barriers, blocking bacteria or avoiding colonization by pathogens. Other strategies to reduce diseases may involve the microbiome, for example through targeted dietary measures. Last but not least, the focus must also be on avoiding and reducing exposure to harmful substances and developing fewer toxic products. The paper appears in Nature Reviews Immunology   Study supports heart health benefits of mushroom powders Tufts University, May 11, 2021 Adding Portobello or shiitake powder to a high-fat diet may protect arteries from the detrimental effects of a high fat diet, according to findings presented at the recent Experimental Biology event. Scientists from Jean Mayer USDA Human Nutrition Research on Aging at Tufts University report that supplementing the diets of lab mice with the mushroom powders had lower body weight gains, compared to animals fed an unsupplemented high-fat diet. “Despite the low body weight gains, EchoMRI analysis of body composition revealed that the overall lean mass was not affected as significantly as fat mass, indicating a plausible positive effect of mushrooms on fat metabolism and lipid profiles,” wrote the researchers in their abstract, published in the FASEB Journal . Mushrooms Consumer interest in mushrooms and their potential health benefits has been growing in recent years, with demand for Reishi, Chaga, Shiitake, Maitake, and the rest has never been higher and the global market was pegged at $18 billion in 2014 (up from $6 billion in 1999). SPINS data shows surging sales of products with various types of mushrooms as primary ingredients across the natural, specialty and conventional multi-outlet retail channels. Reishi was up 91% for the 52 weeks ending September 4, 2016 versus the previous 52 weeks. Impressive growth is also being posted for Chaga (up 46%), Cordycep (up 19%) and Shiitake (up 26%), “While several types of mushrooms have been studied for their effects on serum lipid profiles, few studies have demonstrated edible mushrooms’ effects on atherogenesis,” explained the Tufts researchers in their abstract. Study details L-ergothioneine facts L-ergothioneine was first isolated as a natural compound from rye ergot (Claviceps purpurea) in 1909. It is naturally present in small amounts in food sources like mushrooms, some varieties of black and red beans (Phaseolus vulgaris) and cereals. The human body has a dedicated transporter for the molecule, which is a potent antioxidant.  Lab mice were divided into one of five groups: A low-fat control group (4% fat); a high fat control group (8% fat); a high-fat diet supplemented with Portobello mushroom powder; a high fat diet supplemented with shiitake mushroom powder; or a “control mixture”, which matched to the average nutrient levels of the mushroom powders. After 16 weeks of feeding, the results showed that animals from both mushroom groups had reduced body weight gains, compared to the other dietary groups, with the weight gain lower in the shiitake group compared to the Portobello group. Additional analyses showed that only mice fed the shiitake powder had significantly fewer aortic lesions compared to the high fat control mice and the control mixture. “These results further support the potential role of high levels of bioactive compounds such as ergothioneine, a strong antioxidant in [shiitake mushroom], on suppression of dietary fat induced atherosclerosis, an inflammatory disease of arteries,” wrote the researchers. The study was funded by the USDA and the Mushroom Council.   MIT Study Suggests Six Foot Social Distancing, Limited Occupancy Rules Are Completely Pointless After over a year, scientists have determined that social distancing and limited occupancy rules may be totally useless National File, April 26, 2021   A new study conducted by MIT scientists and released this week reveals that the six foot social distancing and limited occupancy guidelines made law in most of the civilized world have done little to slow the spread of COVID-19, and suggests the only way to reduce the spread of COVID-19 is to limit exposure to highly populated areas and areas where people are physically exerting themselves, such as gyms, or areas where people are singing or speaking, such as churches. The study reveals that the social distancing guidelines employed throughout much of the world for over a year have done nothing to limit the spread of COVID-19, suggesting that the adaption of the guidelines did not stop the spread of the of the China-originated virus, and it can only be slowed with the employment of severe lockdowns. Paradoxically, states and cities that have engaged in severe lockdowns have seen the largest spikes of COVID-19. “We argue there really isn’t much of a benefit to the 6-foot rule, especially when people are wearing masks,” MIT professor Martin Z. Bazant said, as reported by NBC. “It really has no physical basis because the air a person is breathing while wearing a mask tends to rise and comes down elsewhere in the room so you’re more exposed to the average background than you are to a person at a distance.” In other words, widespread mask wearing may simply change the physical vectors of transmission within a given room rather than stop it, effectively making six foot distancing rules pointless. In their study, Bazant and the other researchers declare, “Adherence to the Six-Foot Rule would limit large-drop transmission, and adherence to our guideline, [of limiting time spent in densely populated areas], would limit long-range airborne transmission.” In the guideline, the researchers write, “To minimize risk of infection, one should avoid spending extended periods in highly populated areas. One is safer in rooms with large volume and high ventilation rates. One is at greater risk in rooms where people are exerting themselves in such a way as to increase their respiration rate and pathogen output, for example, by exercising, singing, or shouting.” Bazant also told the media, “What our analysis continues to show is that many spaces that have been shut down in fact don’t need to be. Often times the space is large enough, the ventilation is good enough, the amount of time people spend together is such that those spaces can be safely operated even at full capacity and the scientific support for reduced capacity in those spaces is really not very good.” He added, “I think if you run the numbers, even right now for many types of spaces you’d find that there is not a need for occupancy restrictions.” This comes on the heels of a study that suggests the Pfizer vaccine could cause severe neurodegenerative diseasescaused by brain prions created by the mRNA-style vaccine. National File reported, “‘The current RNA based SARSCoV-2 vaccines were approved in the US using an emergency order without extensive long term safety testing,’ the report declares. ‘In this paper the Pfizer COVID-19 vaccine was evaluated for the potential to induce prion-based disease in vaccine recipients.’ Prion-based diseases are, according to the CDC, a form of neurodegenerative diseases, meaning that the Pfizer vaccine is potentially likely to cause long term damage and negative health effects with regards to the brain.”

Comrades and fellow victims of monetary policies, we bring you a freshly fiscalized serving of the 2 Broke Twimbos podcast, designed to skillfully unpack financial intricacies and knowledgeably provide insight on international economic trends, because in this episode we have the Zim hip-hop hustler GZE himself! Dan & Phil discuss the cancellation of HIFA this year, GZE'‘s musical beginnings with the urban grooves outfit Trinity, ZIm hip-hop in general, his Best Hip-Hop Song of 2018 Star FM Music Award, and trending stories like the situation wiht DJ Cleo & Brickz down South.We wrap up the show with the song Sterek (Remix) by Kay Gee 40 Feat GZE, Earlonthtrack, 8L, Mr Noxa & Trae Yung. Enjoy!Subscribe and listen to 2 Broke Twimbos everywhere podcasts are availableWebsiteiTunesSpotifyStitcherTuneInYouTubeRate and review to win movie tickets!Click here to donate to 2 Broke Twimbos

Alvin Eka Putra, pemain drum paling produktif di kancah musik ekstrem tanah air, bercerita bagaimana ia bertemu dengan drum pertama kali dan apa rasanya bergabung dengan band esktrem metal terbaik tanah air, Deadsquad. Episode ini masih menggunakan nama acara 'Behind That Scene', sebelum berganti menjadi 'Punggung Panggung' di 2020. --- Send in a voice message: https://anchor.fm/agordiclub/message

A special one hour show from Gareth playing some of his favourite discoveries from his time in Indonesia. Having spent time exploring music scenes in both Jakarta and Bandung, he's picked out ten stunners that range from breakcore madness, to surf, house, jazz, grindcore, psych, and a whole lot more. Tracklisting Tesla Manaf - Opaque ft. Rio Abror (Mabes Music, Indonesia) Noxa - Dimusnahkan Diabadikan (self-release, Indonesia) The Southern Beach Terror - Tsunami Bomb (Elevation Records, Indonesia / Sonic Funeral Records, Indonesia) Sunmantra - When You Bite My Lips (Roam Recordings, USA) Superfine - Rabbit Hole (Bhang Records, Indonesia) Bottlesmoker - Bonet Circle (Yes No Wave Music, Indonesia) Sigmun - Behelit (Orange Cliff Records, Indonesia) Rafi Muhammad - Break the Rules (Berita Angkasa Records, Indonesia) Godplant - Radikal (Lawless Jakarta Records, Indonesia) Duo Kribo - Uang (Keepkeep Musik, Indonesia)   With thanks to the British Council for funding the trip

We are all about music most of the time but as we draw closer to July 30th, what do you think of Wamba, otherwise popularly known as Nelso 'Nero' Chamisa? He is one of the frontrunners so maybe you've heard about the guy. Remember, your vote counts for a lot so cast an informed vote! Playlist:  1. Mae Sithole - Miracles ft Taps Mugadza,  2. Tahle Wedzinza ft Innocent (Guitarist ) - Teleunga,  3. Kay Gee 40 - Sterek ft Mr Noxa,  4. Noble Stylz - Zero Kuhwinha,  5. Kazz AKA Mr Boomslang - Jolling,  6. DJ Ganyani - Nomboro feat Jah Prayzah,  7. BlacPerl - King Status,  8. Shungudzo — Long Live The Billionaire.

Marzyliście kiedyś o pilotowaniu własnego mecha? Więc zapnijcie pasy, ponieważ głównym materiałem tego odcinka jest recenzja Titanfall 2. Feanor skupia się w niej przede wszystkim na dynamicznej i efektownej grze wieloosobowej, ale razem z Noxem ocenia również nowy w serii tryb dla pojedynczego gracza. Hardcore’owych graczy może zainteresować także recenzja Nacon Revolution Pro Controller, na którym Feanor szaleje po serwerach w swoim Tytanie. Jeżeli jednak wolicie inne tematy, przygotowaliśmy dla Was obszerny wstęp, a w nim pierwsze wrażenia Izzy’ego z gry Dead Cells, relacja Noxa z Digital Dragons 2017 w...Przeczytaj całość

Mechaniczne dinozaury, rewolwerowcy i kosmiczny żuk… osobliwa mieszanka nam się trafiła w tym odcinku, nieprawdaż? Horizon Zero Dawn, Call of Juarez: Gunslinger i Thumper, bo o tych grach mowa, różnią się właściwie wszystkim. Pierwsza z nich, recenzowana przez Izzy’ego i Noxa, przenosi nas w czasy, gdy Ziemię opanowały roboty naśladujące faunę sprzed milionów lat. Tajemnice tego niezwykle barwnego i niebezpiecznego świata odkrywa razem z graczem Aloy, rudowłosa łowczyni odrzucona przez swoje plemię jeszcze jako niemowlę. Gunslinger natomiast to wydana w 2013 roku najnowsza część stworzonej przez Polaków serii Call of...Przeczytaj całość

Świat stanął na głowie! A wszystko za sprawą powrotu kontrolującej grawitację Kat i jej przyjaciół w przesympatycznej grze Gravity Rush 2, recenzowanej w tym odcinku przez Noxa i Serfera. Podcast odwiedza również gościnnie po dłuższej nieobecności Feanor, z którym ponad rok temu rozmawialiśmy na temat Metal Gear Solid V: The Phantom Pain. Razem z Izzy’m dzielą się pierwszymi wrażeniami m.in. z For Honor i Yakuzy 0. Życzymy przyjemnego lotu… oraz tradycyjnie, miłego słuchania! 2pady.pl Facebook Twitter YouTube Główne tematy podcastu: [1:44] For Honor (wersje na PS4 i PC) – pierwsze...Przeczytaj całość

Batman wiecznie czuwa, nawet w walentynkową noc. A jeżeli zaliczacie się do jego fanów i jesteście ciekawi, jak naszym zdaniem Telltale Games poradziło sobie z historią Człowieka Nietoperza, zapraszamy na recenzję Batman: The Telltale Series autorstwa Noxa. Przed tym krótko dyskutujemy o ostatnich premierach, wspominając takie tytuły jak Yakuza 0, Resident Evil 7: Biohazard, czy Fire Emblem Heroes, czyli pierwszą grę F2P na urządzenia mobilne stworzoną i wydaną przez Nintendo. Odcinek, jak na nasze standardy, wyszedł dość krótki, ale jesteśmy ciekawi, co sądzicie o takiej formie. Czekamy na Wasze komentarze...Przeczytaj całość

Odcinek co prawda trafia do Was tydzień później, niż planowaliśmy, ale za to jest napakowany po brzegi treścią dla fanów gier Nintendo i Sony. Jako że niedawno miała miejsce premiera Gravity Rush 2, zaczynamy od pierwszych wrażeń z tego tytułu, zaś dla osób niezaznajomionych z Kat i jej kontrolującym grawitację kotem Dustym, Serfer przygotował recenzję pierwszej części serii w odświeżonej wersji, czyli Gravity Rush Remastered. Drugą z recenzowanych w tym odcinku gier, tym razem przez Noxa, jest długo oczekiwany The Last Guardian, w którym Fumito Ueda po raz kolejny wciąga...Przeczytaj całość

Altered Avalon is best enjoyed with headphones or surround sound. Starring in this Episode: Damiana: Kristyn M.; Devlin: Mike Wilson; Lizzy: Lizbeth Liu; Ariana: Deborah Adams; Echo: Caitlin Buckley; Mark: Joshua Price; Dana: Claire Wolfe; Sam: Thomas Knight; Yiska: Nick Patrella ; Una: Krystal Donahue; Marcus Sr.: Jacob Anderson Judith: Amy Price; Saras/Amber: Tanja Milojevic Featuring Parker Sade as "Orange" and Sean Foley as the Minister Music by Gregoire Lourme Written by Carol Foley Mixed by Carol Foley

Dawno nie poruszaliśmy na podcaście szerzej tematu bijatyk. Izzy postanowił to zmienić – w tym odcinku wśród komentowanych nowinek pojawiły się te o turnieju Evo 2015, postaciach i zmianach w Street Fighterze V, a daniem głównym stala się przygotowana przez niego recenzja gry Skullgirls, która to pozycja ma szansę spodobać się nie tylko weteranom. Do tego nastąpiła niespodziewana zamiana ról – tym razem to Serfer zastępuje Noxa jako gospodarz podcastu. Życzymy miłego słuchania! 2pady.pl | Patronite | Facebook | Twitter | RSS | Spotify | Apple Podcasts | YouTube Komentowane newsy: Life is Strange – czwarty...Przeczytaj całość

Fani Wolfensteina powinni mieć powody do zadowolenia – ledwo co recenzowaliśmy Wolfenstein: The New Order, a już Nox wziął na warsztat najświeższą część serii a jednocześnie przyjemny powrót do jej korzeni, czyli Wolfenstein: The Old Blood. Prognoza pogody na dzisiaj – będzie padać nazistami. Przed otworzeniem parasoli zdążycie jednak wysłuchać komentarzy Dona i Noxa do wybranych nowinek branżowych. Życzymy miłego słuchania! 2pady.pl | Patronite | Facebook | Twitter | RSS | Spotify | Apple Podcasts | YouTube Komentowane newsy: Batman: Arkham Knight – ogłoszono zawartość przepustki sezonowej (dość drogiej) do nadchodzącej części serii Goat Simulator –...Przeczytaj całość

Zacieranie granicy między życiem a śmiercią, światem realnym a wirtualnym, snem a koszmarem – takich atrakcji dostarcza debiutująca niedawno na PS4 gra Axiom Verge. Lada moment ma się ukazać również na PC, więc tym bardziej zachęcamy do odsłuchania recenzji Noxa. Jeżeli jednak oldschoolowe platformówki w otwartym świecie nie należą do Waszych ulubionych produkcji, może zainteresuje Was gra inspirowana pierwszym Alone in the Dark, której oprawa korzysta jedynie z czerni i bieli do budowania klimatu filmu noir? Mowa o White Night, a o swoich pierwszych wrażeniach z niej opowie Don. Oczywiście...Przeczytaj całość

THE VERY LAST RADIO KUNAKIRWA PODCAST. After 5 wonderful years of giving you Zimbabwean music we call time on the project. Zimbabwe music is a wealth of diveristy and talent. Thank you to the Zim music fans and supporters of Radio Kunakirwa. Represeting, Zimbabwe, Zimbabweans and Zimbabwean Music always. 1. Winky D - Ninja Saturday 2. King Shaddy - Danmore 3. Russo & MacDee - Kana Zvanaka 4. Queen Vanessa - Hey Lover feat Buffalo Souljah 5. Stunner - Mudhara Bhanda ft Shastro 6. Cindy - Appointment 7. Taurai - Better Man 8. Trevor Dongo - Chokwadi ft Shaffir 9. Tembalami - Brighter Day ft Carol Wutawunashe 10. Nastase - Shungu 11. DNA - Dai 12. Fortune Mparutsa - The Way I Look At You 13. Kure Tribute to TBA - Various Artists 14. Mudiwa - Chaputika Zvine Staira 15. Zim All Stars (Juan Take, Ms Nadia Nakai, Anonymous, Andre, GPB, Kapital K, Thai, Lym-C) - Fire Fire Fire 16. Jnr Brown, Alkanemo & Gze - MaTennis nemabhingo 17. Soosh Matix - Close Ur Eyez 18. Prometheus - Chindipa Rudo 19. Xpandables - Reply Me One Day ft Roki 20. Sanii Makhalima - Wandada featuring Shinso & Mbale 21. Freeman - Dancehall Doctor ft Lady Squanda 22. Alkanemo - Chamhembe Man 23. Kudzi Ku - Facebook 24. Maskiri - Miss Officer ft Sanii Makhalima & Mzimba 25. Dija, Mr Noxa, Trae Yung & Snazzy - Soldiers Tribute 26. Varaidzo - Chiso 27. Nicole - Ndadanana Newe 28. Otis Ngwabi - Nomzamo ft Bella 29. Simba Tagz - Stronger 30. Tha Collektive - Party 31. TK Paradza - Kana Ndikadai ft BKay n Kazz 32. Reverb7 - Seskhona ft The Bassist & DJ Naida 33. Juss Russ - Ndavakuenda ft Renee Mare 34. Thomas Mapfumo - Ndave Kuenda

Der Naturstoff Betulinsäure (BA) induziert effektiv Apoptose in Tumorzellen. Vorarbeiten der Arbeitsgruppe zeigten, dass BA auf primären Leukämiezellen besser Apoptose in vitro induziert als viele der heute verwendeten Zytostatika. Zelltod wird dabei direkt über Aktivierung des intrinsischen Apoptosesignalwegs am Mitochondrium ausgelöst. Aufbauend auf diesen Daten war es Ziel dieser Dissertation, BA in die Kombinationsabfolge der Polychemotherapie der Leukämie einzuordnen. Zunächst wurde untersucht, mit welchen Zytostatika der heutigen Leukämietherapie Betulinsäure kooperiert, so dass der gemeinsame Einsatz beider Substanzen synergistische Apoptose auslöst. Dabei stellte sich heraus, dass Betulinsäure mit den drei Medikamenten Asparaginase, Doxorubicin und Vincristin kooperiert, sowohl auf sensitiven Tumorzelllinien, auf Zytostatika-resistenten Zelllinien als auch auf primären Zellen von Kindern mit akuter Leukämie. Im Hauptteil der Arbeit wurde untersucht, welche intrazellulären Signalmechanismen für die effektive Apoptoseinduktion von BA mit Asparaginase, Doxorubicin oder Vincristin verantwortlich sind. Dabei erwiesen sich für alle drei untersuchten Zytostatika die Signalmechanismen als identisch. Mittels des Einsatzes von transgenen Tumorzellinien, der Überexpression rekombinanter Proteine sowie des Knockdowns endogener Proteine über RNA-Interferenz konnte gezeigt werden, dass folgende Signalmoleküle die synergistische Apoptoseinduktion vermitteln: der Transkriptionsfaktor p53; das pro-apoptotische BCL-2 Familienmitglied NOXA, dessen Expression über p53 reguliert wurde; die mitochondriale Aktivierung mit Freisetzung von z.B. Cytochrom-C, die durch Mitglieder der BCL-2 Familie reguliert wurde; hierbei ermöglichte die p53-abhängige Regulation von NOXA eine Verschiebung des Gleichgewichts in Richtung zur Apoptose; Caspasen (Casp-3 und -9). Um die intrazelluläre Signaltransduktion auch an Patienten-abgeleiteten Zellen untersuchen zu können, wurde eine neue Technik etabliert: Kindliche ALL-Zellen wurden in immuninkompetenten Mäusen vermehrt und mittels eines optimierten Protokolls der Elektroporation mit small interfering RNA transfiziert. Auch hier zeigte sich eine Abhängigkeit der synergistischen Apoptoseinduktion von p53 und NOXA. Die dargelegten Untersuchungen legen nahe, BA in zukünftigen prä-klinischen und klinischen Studien der Leukämie in der Nähe von Doxorubicin, Asparaginase oder Vincristin einzusetzen, um von der günstigen p53-abhängigen Aktivierung von NOXA durch Zytostatika-Kombination zu profitieren.

Monomeric actin controls the activity of the transcription factor Serum Response Factor (SRF) via its coactivator MAL/MRTF-A. Upon signal induction, MAL is released from actin, binds SRF and activates target gene expression. In order to characterise the physiological role of this signalling pathway, I screened on a genome wide basis for target genes by transcriptome analysis. A combination of actin binding drugs (Cytochalasin D and Latrunculin B), targeting monomeric actin, was used to specifically and differentially interfere with the complex between MAL and actin. 210 genes primarily controlled by monomeric actin were identified in mouse fibroblasts. Among them more than 30% have been already found in screens for SRF target genes, supporting the validity of the screening approach. As expected, a lot of genes were involved in cytoskeleton organization. However, genes having anti-proliferative or pro-apoptotic features were identified surprisingly to the same extent. Consistently, I could demonstrate an antiproliferative function of MAL. More specifically, several genes interfering with the MAPK pathway were identified. One of them was Mig6/Errfi1, a negative regulator of EGF receptors. Mig6 induction by LPA or FCS revealed to be dependent on MAL, monomeric actin and the small GTPases Rho. Activated forms of MAL or SRF were sufficient to induce Mig6 expression. Subsequently, a Mig6 promoter element was found to be necessary to mediate MAL/SRF induction. Moreover, induction of Mig6 through the Actin-MAL pathway led to the downregulation of the mitogenic EGFR-MAP kinase cascade. For the first time a transcriptional link between G-actin levels sensed by MAL and the regulation of EGFR signalling was established. Furthermore, after having demonstrated that MAL induces apoptosis, I focused on the characterisation of two proapototic targets identified in the screen: Bok and Noxa. Bok and Noxa were induced by activators of the Rho-Actin-Mal-Srf pathway on a MAL dependent manner. The study of the Bok promoter revealed the existence of a response element that was necessary for the induction by MAL-SRF. Interestingly, apoptotic inducers like staurosporine, TNFα, or the DNA damaging agent Doxorubicin triggered MAL-SRF mediated transcription. As SRF controls the expression of the anti-apoptotic genes Bcl2 and Mcl1, the results from this work places thus SRF as a key transcription factor controlling the balance between pro and anti apoptotic genes in response to external cues.

Background: Human renal cell carcinoma (RCC) is very resistant to chemotherapy. ABT-737 is a novel inhibitor of antiapoptotic proteins of the Bcl-2 family that has shown promise in various preclinical tumour models. Results: We here report a strong over-additive pro-apoptotic effect of ABT-737 and etoposide, vinblastine or paclitaxel but not 5-fluorouracil in cell lines from human RCC. ABT-737 showed very little activity as a single agent but killed RCC cells potently when anti-apoptotic Mcl-1 or, unexpectedly, A1 was targeted by RNAi. This potent augmentation required endogenous Noxa protein since RNAi directed against Noxa but not against Bim or Puma reduced apoptosis induction by the combination of ABT-737 and etoposide or vinblastine. At the level of mitochondria, etoposide-treatment had a similar sensitizing activity and allowed for ABT-737-induced release of cytochrome c. Conclusions: Chemotherapeutic drugs can overcome protection afforded by Mcl-1 and A1 through endogenous Noxa protein in RCC cells, and the combination of such drugs with ABT-737 may be a promising strategy in RCC. Strikingly, A1 emerged in RCC cell lines as a protein of similar importance as the well-established Mcl-1 in protection against apoptosis in these cells.