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Inspired... with Simon Guillebaud
A Severe Mercy | Nadim Ednan-Laperouse OBE

Inspired... with Simon Guillebaud

Play Episode Listen Later May 29, 2025 65:37


Nadim was a successful entrepreneur, happily married, and with two wonderful children. But the dream life was shattered when he took his daughter Natasha and her best friend on holiday to France. Tragically, Natasha had an anaphylactic reaction shortly after takeoff after ingesting sesame seeds in her sandwich, from which she never recovered. Subsequently, Nadim and his wife Tanya founded the Natasha Allergy Research Foundation, and their campaigning - for which they were both awarded an OBE by the Queen - has led to changes in the law. Nadim's journey to faith through this horrendous experience is deeply touching, and God has opened doors of real influence and opportunity for him to witness gently to the Prince of Peace in many different contexts. I spent much of this interview in tears, so it's a different flavour from previous episodes, but deeply moving and inspiring.Do check out www.narf.org.ukAnd you can contact Nadim at nadim.el[@]narf.org.uk ---Order the Inspired Book nowSupport our work in Burundi: greatlakesoutreach.org/inspired ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠---Follow us on Instagram: @inspiredwith.sgWeekly episode WhatsApp link: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠greatlakesoutreach.org/whatsappWeekly email notification: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠greatlakesoutreach.org/inspiredemail⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠For more from Simon, visit: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠simonguillebaud.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠---Produced by Great Lakes Outreach - Transforming Burundi & Beyond: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠greatlakesoutreach.org⁠⁠⁠⁠⁠

Parsha Podcast - By Rabbi Yaakov Wolbe
Parshas Bamidbar (Rebroadcast)

Parsha Podcast - By Rabbi Yaakov Wolbe

Play Episode Listen Later May 25, 2025 56:48


We kickstart the Book of Numbers with a census of the twelve tribes of Israel – not including the tribe of Levi who is counted independently – conducted by Moses, Aaron, and the most distinguished leaders of said tribes. Subsequently, we read about the banners of the tribes and their assigned encampments, the transference of […]

All Rabbi Yaakov Wolbe Podcasts
Parshas Bamidbar (Rebroadcast)

All Rabbi Yaakov Wolbe Podcasts

Play Episode Listen Later May 25, 2025 56:49


We kickstart the Book of Numbers with a census of the twelve tribes of Israel – not including the tribe of Levi who is counted independently – conducted by Moses, Aaron, and the most distinguished leaders of said tribes. Subsequently, we read about the banners of the tribes and their assigned encampments, the transference of the sanctity of the firstborn to the Levites, and the designated role of each of the Levite families.– – – – – – – – – – – – – – – – – – – – – –DONATE to TORCH: Please consider supporting the podcasts by making a donation to help fund our Jewish outreach and educational efforts at https://www.torchweb.org/support.php. Thank you!– – – – – – – – – – – – – – – – – – – – – –Email me with questions, comments, and feedback: rabbiwolbe@gmail.com– – – – – – – – – – – – – – – – – – – – – –SUBSCRIBE to my Newsletterrabbiwolbe.com/newsletter– – – – – – – – – – – – – – – – – – – – – –SUBSCRIBE to Rabbi Yaakov Wolbe's PodcastsThe Parsha PodcastThe Jewish History PodcastThe Mitzvah Podcast This Jewish LifeThe Ethics PodcastTORAH 101 ★ Support this podcast ★

The Parasha with Rabbi Dweck
Behar-Behukoati 2025: Let Go

The Parasha with Rabbi Dweck

Play Episode Listen Later May 22, 2025 31:52


The book of Vayikra ends with hard warnings against Israel should they walk with God with indifference. He too will be indifferent to them and the world will feel as though it is turning on them. Subsequently there is an intriguing mitzvah presented that deals with what's called "Temura" or "exchange". Prohibiting one from attempting to exchange an animal that was given to God for an offering with a different animal whether it be better or worse. In this episode we examine the problem with that and how fear and the need for control underlies it, as well as why it is related to the issue of indifference.

Totally Rad Christmas!
‘80s Wrestling pt4 (w/ Wrestling Bros)

Totally Rad Christmas!

Play Episode Listen Later May 21, 2025 69:41


What's up, dudes? It's all about WWF Prime Time Wrestling Christmas 1987, battle royale style with Jeremy Phelps the Alamo City Santa,  Ron from the Film Strip podcast, Joe from Now Watch This, Manny from Feliz Christmas, Merry Navidad, and CJ from Rose Suchak Ladder! We talk Bobby the Brain and Gorilla! Also, we dive into Hogan and Dibiasi! We body slam Strike Force and the Islanders! This episode has it all!Airing December 21, 1987, the matches begin with Hercules taking on Junkyard Dog. After a double clothesline, Hercules pins JYD with help from the ropes. Following that, the Conquistadors fight the Young Stallions. There follows a scissor flip, several chokeholds, a shot to the midsection and flip and drop kick for the Stallions victory. Next, in a promo, Hulk turns down Ted Dibiasi's offer to buy the championship.Iron Mike Sharpe and Ultimate Warrior fight, with the latter slamming the former's face into the turnbuckle. Meanwhile, Bobby and Gorilla argue about gift giving, and plug the free Royal Rumble matchup on USA. Also, Ted Dibiasi's talks about how he spent his Thanksgiving: with money! Hacksaw Jim Duggan performed a football charge to pin Rex King. Subsequently, Danny Houston was counted out of the ring giving Danny Davis the win. As well, Brutus the Barber Beefcake did a promo about his barber's tool, calling out Greg Valentine. Then Brain gives Gorilla a box of stolen junk from Caesar's Palace in Atlantic City! Finally, Strike Force—Rick Martel and Tito Santana—collided with the monstrous Islanders, Haku and Tama. It's a brutal beatdown, eventually all wrestlers fighting outside the ring. The Islanders win by count out but didn't win the belt!Royal Rumble plug? Once. Weasel chant? A few times. Falling outside the ring Constantly! So grab your belt, get on the ropes, and backflip to this episode on Prime Time Wrestling Christmas 1987!Film Strip PodcastFB: @filmstrippodIG: @filmstrippodTwitter: @FilmStripPodJ-WaveFB: @catchthewavebabyIG: @catchthewavebabyAlamo City SantaFB: @alamocitysantaIG: @alamocitysantaNow Watch ThisFB: @nowwatchthispodTwitter: @nowwatchthispodIG: @now_watch_this_podFeliz Christmas, Merry NavidadFB: @FCMNPodcastTwitter: Give us a buzz! Send a text, dudes!Check us out on Facebook, Twitter, Instagram, Totally Rad Christmas Mall & Arcade, Teepublic.com, or TotallyRadChristmas.com! Later, dudes!

The Working Dog Depot Podcast
Episode #49 Tony Pallotta "A persons ability to learn is based on your ability to teach"

The Working Dog Depot Podcast

Play Episode Listen Later May 20, 2025 89:27


Send us a textWe truly enjoyed interviewing Tony. There will likely be a second episode. After listening to this one we know you'll see why we need to have him on again. Lots of subjects were covered in a slightly longer episode than normal. Tony Pallotta started training dogs in 1993, with over 25 years of experience thus far, his knowledge and experience has made him a leader within his industry. Like most it is not uncommon he started out in obedience training and found within him the passion and desire to learn, absorb and to become more competent and proficient within. It was with that mindset and goal he began to study and train in the sport of Schutzhund. Once he became proficient in Schutzhund as a successful handler and decoy. He realized early on that he felt there were some key components missing that caused him to raise some questions about what was being achieved and what was being taught to believe in. Subsequently he continued on with his desire to study and research and he began to prepare dogs for protection sports. This tested the handler's skills as well as the dog's skills to work in un-patterned programs. This is known as a real street type application in personal protection for both K9 and Handler. This experience allowed the furthering of comprehension and knowledge base by competing in protection venues such as, K9 Pro Sport's, Sundog Protection Pro Series and Iron dog.His desire to understand and specialize within the field took him to Italy. While in Italy working with Renzo Zolli and his community of training partners reaching into Austria and abroad, there a re-affirmation of skill set and advancement occurred. The realization that there was so much more to learn he continued on his travels to study disciplines and to further acquire a knowledge of skills and excellence, it was then that he landed in the Netherlands and began working with Erik Huft in the KNPV program. This was an unanticipated, eye opening experience for Tony and a catapult into a whole new style of training in the world of working dogs. At that time little was known about the Royal Dutch Police Dog Association Program outside of the Netherlands. Many of the world's Elite Military and police K9's have come from this program and it was with great honor for Tony to have been given the opportunity to work and study with such high caliber trainer's.https://workingk9.ca/workingk9-trainer.htmlWe are pleased to announce that Vested Interest in K9's has become our newest sponsor. Vested Interest in K9s, Inc. is a 501c(3) non-profit whose mission is to provide bullet and stab-protective vests and other assistance to dogs. Check it out www.vik9s.org. Please welcome Ray Allen Manufacturing as a sponsor to the podcast. Go to the most trusted name in industry for all of your k9 related equipment. For a 10% discount use the RAMWDDP10 discount code.Welcome our sponsor Gold Coast K9. Gold Coast K9 trains and deploys hand-selected service dogs for personal and family protection, police agencies, and school districts. Their training programs rank among the best and most trusted in the world. Follow Gold Coast k9 on all social media platforms. For 10% off merchandise use the GCK910 discount code on their website www.goldcoastk9.comHLTK9 Conference continues to be a supporter of the WDDP. They are gearing up for the next conference in Myrtle Beach SC. Plan ahead, the 2025 conference will be April 1,2,3, 2025. Register today at www.htlk9.com. Welcome out newest sponsor NCK9LLC. Located in Four Oaks NC, just east of Raleigh NC. Jim O'Brien and staff offer a variety of K9 services. Contact them at Phone : 919-353-7149 Email: jobrien@nck9.us

Untherapeutic
How to be Vulnerable in Relationship with Dr. Justin Dodson

Untherapeutic

Play Episode Listen Later May 20, 2025 28:54


Send us a textVulnerability is often talked about in relationships, especially among men. However, with so many voices about what it means to be vulnerable, why it's important and what it actually looks like – this important topic can become blurred at best.  Still, being vulnerable is an essential component of connection and bridge the gap in communication. Not only does it help establish trust in a relationship, but it allows our spouse to see who we are in totality.  It's more than a word, but a way being that allows to show up authentically.  This is a must listen podcast episode for anyone who is in a relationship, or who simply wants to be better at doing relationships.  Dr. Nic Hardy is joined by Dr. Justin Dodson as they delve into the topic of vulnerability. Listen and get answers to many of the most asked questions on this topic. ·      What does vulnerability really look like in relationships? ·      What happens when it's used against you later in the relationship? ·      What keeps people from being vulnerable in relationships and is it something you can learn? ·      What are common misconceptions about this topic? ·      What do you need in order to be vulnerable? Don't forget to follow Dr. Nic Hardy & the  Untherapeutic Podcast on Instagram. If you are in the state of Texas and would like to schedule your first counseling appointment, visit hbhtexas.com  Make sure you also follow Dr. Justin Dodson on Instagram.  About Dr. Justin Dodson Justin Keith Dodson creates safe and supportive environments where individuals can be seen, heard, and catapulted into a redefined future. As the visionary behind Navigating Courage, Counseling & Consultation, LLC, Dodson and his team of mental health professionals, specifically focusing on males, prioritize the cognitive and emotional well-being of adult men through personalized coaching and therapy and consulting organizations looking to improve employee culture & well-being."The realization of my innate ability to truly understand people fueled my aspiration to become a therapist. Recognizing the potential to fulfill my lifelong desire, I wanted to provide for others what I always needed."Dr. Dodson achieved the groundbreaking feat of being the first African American male to attain a Master's in Counseling from Lipscomb University. Subsequently, he went on to earn a Ph.D. in Counselor Education and Supervision from The University of Memphis, solidifying his trailblazing legacy. In his book, "The Courage of a Single Freckle, Navigating Your Black," Dodson delves into the complex intersection of mental health, race relations, implicit and explicit bias, and identity development. Dr. Dodson has been featured in People Magazine, Refinery 29, and, Teen Vogue, Ebony, & Essence Magazine.    

Kings and Generals: History for our Future
3.151 Fall and Rise of China: The Suiyuan Operation

Kings and Generals: History for our Future

Play Episode Listen Later May 19, 2025 38:49


  Last time we spoke about the February 26th incident. Within the turbulent “ government of assassination” period of 1936 Japan, a faction of discontented junior officers, known as the Kodoha, believed that their emperor, Hirohito, was being manipulated by corrupt politicians. In a desperate bid for what they termed a "Showa Restoration," they meticulously plotted a coup d'état. On February 26, they launched a rebellion in Tokyo, attempting to assassinate key figures they deemed responsible for undermining the emperor's authority. The young officers executed coordinated attacks on prominent leaders, resulting in several deaths, while hoping to seize control of the Imperial Palace. However, their plan unraveled when their actions met with unexpected resistance, and they failed to secure strategic locations. Dark snow blanketed the city as Hirohito, outraged by the violence, quickly moved to suppress the uprising, which ultimately led to the downfall of the Kodoha faction and solidified the military's grip on power, ushering in a new era marked by militarism and radicalism.   #151 The Suiyuan Operation Welcome to the Fall and Rise of China Podcast, I am your dutiful host Craig Watson. But, before we start I want to also remind you this podcast is only made possible through the efforts of Kings and Generals over at Youtube. Perhaps you want to learn more about the history of Asia? Kings and Generals have an assortment of episodes on history of asia and much more  so go give them a look over on Youtube. So please subscribe to Kings and Generals over at Youtube and to continue helping us produce this content please check out www.patreon.com/kingsandgenerals. If you are still hungry for some more history related content, over on my channel, the Pacific War Channel where I cover the history of China and Japan from the 19th century until the end of the Pacific War. So we last left off with the February 26th incident breaking out in Japan, but now I would like to return to China. Now we spoke a little bit about some influential Japanese politicians in the previous episode. Prime Minister Satio Makoto oversaw Japan from May 1932 to July 1934, succeeded by Prime Minister Keisuke Okada from July 1934 to March 1936. The foreign policy of Japan towards China during the Saitō and Okada administrations exhibited a notable paradox, characterized by two conflicting elements. On one hand, Foreign Minister Hirota championed a diplomatic approach that emphasized friendship, cooperation, and accommodation with China. On the other hand, the military actively undermined the authority of the Nationalist government in northern China, creating a significant rift between diplomatic rhetoric and military action.    The Okada cabinet then endorsed the Army Ministry's "Outline of Policy to Deal with North China" on January 13, 1936. This policy document explicitly proposed the eventual detachment of five provinces, Hubei, Chahar, Shanxi, Suiyuan, and Shandong from the Nationalist government in Nanking. The approval of this outline marked a pivotal moment, as it represented the first official government endorsement of the military's longstanding agenda and underscored the army's evolution from a mere rogue entity operating in the region to the de facto authority dictating the course of Japan's policy towards China. Despite this, on January 22, during the 68th Diet session, Hirota reaffirmed his dedication to fostering better ties with China, to which a representative from the Chinese Ministry of Foreign Affairs responded positively. The Nationalist government in Nanjing also expressed interest in engaging in formal negotiations. However, this diplomatic initiative quickly faltered, and the expected discussions in Nanjing never took place. Shortly thereafter, a mutiny by young army officers on February 26, 1936, led to the fall of the Okada cabinet. Following Prince Konoe Fumimaro's refusal of the imperial mandate to form a new government, Hirota stepped in to establish a cabinet on March 9. General Terauchi Hisaichi was appointed as the Minister of the Army, Admiral Nagano Osami took charge of the Navy Ministry, and Baba Eiichi became the finance minister. Hirota briefly served as foreign minister until Arita Hachirö, who had just submitted his credentials as ambassador to China on March 6, returned to Japan. The Hirota Koki cabinet, established immediately following the February 26 incident further entrenched military influence in politics while allowing interservice rivalries to impede national objectives. In May 1936, Hirota, influenced by army and navy ministers, reinstated the practice of appointing military ministers solely from the ranks of high-ranking active-duty officers. He believed this would prevent associations with the discredited Imperial Way faction from regaining power. By narrowing the candidate pool and enhancing the army's power relative to the prime minister, Hirota's decision set the stage for army leaders to leverage this advantage to overthrow Admiral Yonai's cabinet in July 1940. Arita began his new job by meeting with Foreign Minister Chang Chen while hearing views from the Kwantung Army chief of staff General, Itagaki Seishiro. Yes, our old friend received a lot of promotions. Itagaki had this to say about the Kwantung Army's policy in China "The primary aim of Japan's foreign policy, is the sound development of Manchukuo based upon the principle of the indivisibility of Japan and Manchukuo. If, as is probable, the existing situation continues, Japan is destined sooner or later to clash with the Soviet Union, and the attitude of China at that time will gravely influence operations [against the Soviet Union]." The Kwantung Army's was growing more and more nervous about the USSR following its 7th comintern congress held in July and August of 1935. There it publicly designated Japan, Germany and Poland as its main targets of comintern actions. Japanese intelligence in the Red Army also knew the Soviets were gradually planning to expand the military strength so they could face a simultaneous west and east front war. This was further emboldened by the latest USSR 5 year plan. Alongside the growing Red northern menace, the CCP issued on August 1st a declaration calling upon the Nationalist Government to end their civil war so they could oppose Japan. By this time the CCP was reaching the end of its Long March and organizing a new base of operations in Yenan in northern Shanxi. The developments by the USSR and CCP had a profound effect on Japan's foreign policy in China. The Kwantung Army believed a war with the USSR was imminent and began to concentrate its main force along the border of Manchukuo. The Kwantung Army's plan in the case of war was to seize Vladivostok while advancing motorized units towards Ulan Bator in Outer Mongolia, hoping to threaten the Trans-Siberian Railway near Lake Baikal. Their intelligence indicated the USSR could muster a maximum of 250,000 troops in eastern Siberia and that Japan could deal with them with a force two-thirds of that number. The IJA at that point had inferior air forces and armaments, thus urgent funding was needed. The Kwantung Army proposed that forces in the home islands should be reduced greatly so all could be concentrated in Manchuria. To increase funding so Kwantung leadership proposed doing away with special allowances for Japanese officials in Manchuria and reorganizing the Japanese economic structure. The Kwantung leaders also knew the submarine base at Vladivostok posed a threat to Japanese shipping so the IJN would have to participate, especially against ports and airfields. All said and done, the Kwantung Army planned for a war set in 1941 and advised immediate preparations. On July 23, 1936, Kanji Ishiwara presented the army's document titled “Request Concerning the Development of Industries in Preparation for War” to the Army Ministry. He asserted that in order to prepare for potential conflict with the Soviet Union, Japan, Manchukuo, and North China must have the industries critical for war fully developed by 1941. Ishiwara emphasized the urgent need for rapid industrial growth, particularly in Manchukuo. He followed this request on July 29 with a draft of a “Policy on Preparations for War” regarding the Soviet Union, advocating for immediate reforms to Japan's political and economic systems to facilitate economic expansion and lay the groundwork for future fundamental changes. However, he cautioned that if significant turmoil erupted in economic sectors, Japan must be ready to execute a comprehensive overhaul without delay. At the same time, the Hirota cabinet initiated a review of its policy towards China. In the spring of 1936, a secret committee focused on the Current Situation was formed, consisting of officials from the Army, Navy, and Foreign ministries. Their discussions led to the adoption of the "Measures to Implement Policy toward China" by the Four Ministers Conference on August 11, along with the "Second Outline of Policy to Address North China," which the cabinet approved as part of the "Fundamentals of National Policy" on the same day. The first of these documents outlined the following actionable steps: “1. Conclusion of an anti-Communist military pact. a) To prepare for the conclusion of such a pact, a special secret committee of military experts from both countries should be organized. b) Their discussions should cover the scope and substance of the pact and ways and means of realizing the objectives of the pact.  2. Conclusion of a Sino-Japanese military alliance. A special secret committee, composed of an equal number of delegates from each nation, should be organized to prepare for the conclusion of an offensive and defensive alliance against attack by a third country.  3. Acceleration of solutions of pending questions between China and Japan. a) Engagement of a senior political adviser: The Nationalist government should engage a senior Japanese political adviser to assist in the conduct of the domestic and foreign affairs of the Nationalist government. b) Engagement of military advisers: The Nationalist government should engage military advisers, along with military instructors. c) Opening of airline services between China and Japan: Airline services between China and Japan should be opened immediately. To realize such a service, various means should be used to induce the Nanking authorities to establish an airline corporation in North China, to begin flights between Formosa and Fukien province, and to start test flights between Shanghai and Fukuoka. d) Conclusion of a reciprocal tariff treaty: A reciprocal tariff treaty should be concluded promptly between China and Japan, on the basis of the policy approved by the ministries concerned, with regard to the abolition of the special trade in eastern Hopei province and the lowering of the prohibitively high tariffs. For this purpose Japan should, if necessary, propose the creation of a special committee composed of Japanese and Chinese representatives.  4. Promotion of economic cooperation between China and Japan. Japan should promote cooperation with the common people of China to establish realistic and inseparable economic relations between China and Japan that will promote coexistence and co-prosperity and will be unaffected by changes in the Chinese political situation. “ The document also included suggestions for Japan's economic expansion into South China. This included tapping into the natural resources of the provinces of Fujian, Guangdong, and Guangxi, building a railway between Guangzhou and Swatow, and establishing air routes between Fuchoz and Taipei, which would connect to services in Japan and Thailand. It also called for survey teams to be dispatched to explore the resources of Sichuan, Gansu, Xinjiang, and Qinghai provinces, and for support to be provided to the independence movement in Inner Mongolia. However, these initiatives presented significant challenges. The preface to the "Second Outline of Policy to Deal with North China" cautioned, "In implementing this policy, we must carefully consider the Nanking government's prestige and avoid actions that could prompt it to adopt an anti-Japanese stance in response to the desires of the Chinese people."  On September 19th, six fundamental points for a settlement in North China were dictated to China to “establish a common defense against communism, promoting economic cooperation, lowering tariffs, initiating an airline service between the two nations, employing Japanese advisers, and controlling subversive Koreans." September 22 was set as the deadline for a response from China. While agreeing to some Japanese requests, the Chinese included several counter-demands that the Japanese found completely unacceptable. These demands required Japan to “(a) refrain from using armed intervention or arbitrary actions in its dealings with China, (b) recognize China as an equal and sovereign state, (c) avoid leveraging antigovernment groups or communist elements, and (d) remove any derogatory references to China from Japanese textbooks. The Chinese also insisted that any agreement regarding North China “must precede the annulment of the Tanggu and Shanghai cease-fire agreements, the disbanding of the East Hopei regime, a prohibition on unauthorized Japanese flights over North China, a ban on smuggling activities by Japanese, the restoration of China's right to control smuggling, and the disbandment of the illegal East Hopei government along with the armies of Wang Ying and Prince De in Suiyuan”. Now that mention of a Prince De in Suiyuan brings us to a whole new incident. This podcast series should almost be called “the history of Japanese related incidents in China”. Now we've spoken at great lengths about Japan's obsession with Manchuria. She wanted it for resources, growing space and as a buffer state. Japan also had her eyes set on Inner Mongolia to be used as a buffer state between Manchukuo, the USSR and China proper. Not to mention after the invasion of North China, Inner Mongolia could be instrumental as a wedge to be used to control Northern China. Thus the Kwantung Army began fostering a Mongolian independence movement back in August of 1933. They did so through a special organ led by chief of the general staff Koiso Kuniaki. He began work with the Silingol League led by Prince Sonormurabdan or “Prince So” and another influential Mongol, Prince Demchukdongrob or “Prince De”. Prince De was the West Sunid Banner in Northern Chahar. Likewise the Kwantung Army was grooming Li Xuxin, a Mongol commoner born in southern Manchuria. He had been a bandit turned soldier absorbed into Zhang Xueliangs army. Li had distinguished himself in a campaign against a group of Mongols trying to restore the Qing dynasty to further establish an independent Mongolia. During Operation Nekka Li had served in a cavalry brigade under Zu Xingwu, reputed to be the best unit in Zhang Xueliangs Northeastern border defense army. He led the army's advance unit into western Shandong. Afterwards Li suddenly became friends with Major Tanaka Hisashi, the head of the Special Service Agency at Dungliao where he defected to the Kwantung Army. He soon was leading a force too strong to be incorporated into the Manchukuo Army, thus it was disbanded, but his Kwantung Army buddies encouraged him to move to Tolun in Rehe province. At one point during the Nekka campaign, Li's army was threatened by a strong Chinese counterattack, but they had Manchukuo air support allowing them to capture Tolun. This victory launched what became the East Chahar Special Autonomous District with Li becoming a garrison commander and chief administrator.  Back in time, upon the founding of the Chinese Republic, the affairs of Inner Mongolia fell upon the Bureau of Mongolian and Tibetan Affairs. This was reorganized in 1930 into the Commission on Mongolian and Tibetan Affairs when the provinces of Chahar, Suiyuan and Ningxia were organized. Prince De had been a member of a nationalist group known as the Young Mongols, although his aim was self-determination for Inner Mongolia within China, not independence. The Nationalist government's support for Chinese settlement in Mongol territories and its disregard for Mongol perspectives quickly triggered a rise in Mongol nationalism and anti-Chinese feelings. This was exacerbated by the government's introduction of a law on October 12, 1931, requiring local Mongolian administrative units to consult with hsien officials on matters concerning their administration. The nationalist sentiment was further fueled by the presence of the neighboring Mongolian People's Republic in Outer Mongolia and the establishment of Xingan province in western Manchuria by Manchukuo authorities in March 1932. This new province included the tribes of eastern Inner Mongolia and granted them greater autonomy than other Manchukuo provinces while banning Chinese immigration into it. When Nanjing did not react to these developments, Prince De and his supporters took steps toward gaining autonomy. On July 15th, 1933, Mongol leaders from western Inner Mongolia gathered at Pailingmiao for two weeks to deliberate on a declaration for regional independence. Although many princes were initially hesitant to take this step, they reconvened on August 14 and sent a cable to Nanjing announcing their decision to create an autonomous Mongolian government. The cable was signed by Prince So and Prince De. Over the following two months, additional conferences at Pailingmiao were held to organize the new government, which would operate under Nanking's guidance but without involvement from provincial chairmen. On October 22, Prince Yun, head of the Ulanchap League and a close ally of Prince De, was elected to lead the new regime, with Prince De assuming the role of chief of its political affairs bureau. After receiving a cable from the Mongolian leaders in August, Nanjing quickly sent Minister of the Interior Huang Shao-hung and Xu Qingyang, head of the Commission on Mongolian and Tibetan Affairs, to halt the movement. However, the Mongols declined to travel to Kalgan or Kueisui to meet Huang. In November, as the leader of a special commission appointed by Nanjing, Huang reached an agreement with Yun De and other Mongolian leaders concerning a proposal that abandoned the Mongols' demand for an autonomous government. This agreement was later altered by Nanjing, and its essential points were excluded from a measure approved by the Central Political Council of the Kuomintang on January 17, 1934. The dispute reignited, fueled by the Nationalist government's rising concerns over the anticipated enthronement of Pu Yi in Manchukuo. On February 28, the Central Political Council enacted a measure that outlined "eight principles of Inner Mongolian autonomy" and created the Mongolian Local Autonomous Political Council. Since these principles did not grant authority over foreign and military affairs, powers explicitly reserved for the central government in the January measure, they were seen as a concession to the Mongols and were accepted. On March 7, the central government issued regulations to establish a semi autonomous regime for Inner Mongolia, which was officially launched at Pailingmiao on April 23. Although the council was led by three moderate princes, Prince Yun, supported by Princes So and Sha, the real administrative authority was held by Prince De, who served as the secretary-general. Most of the twenty-five council members were of Mongolian royalty, through whom Prince De aimed to fulfill his objectives. Nevertheless, the Nationalist government seemed to consider the council merely a token gesture to placate De, as Nanking never provided the promised administrative funds outlined in the "eight principle declaration." Was not much of a shock Prince De sought support from the Kwantung Army, which had established contact with him as early as June 1934. Japanese pressures in North China were starting to alter the power dynamics, and after the first Western incident in Jehol in February 1935, it compelled the relocation of Sung Queyuan's army from Chahar to Hopei, providing encouragement to Prince De. In May, he met with Kwantung Army Vice Chief of Staff Itagaki Seishirö, Intelligence Section Chief Kawabe Torashirö, and staff officer Tanaka Ryükichi, where he was officially informed for the first time about the Kwantung Army's intention to assist him. On July 25, the Kwantung Army drafted its "Essentials of Policy toward Inner Mongolia," which regarded Japanese support for cooperation between De and Li Xuxin as part of their strategic preparations for a potential conflict with the Soviet Union. Shortly after this policy was adopted, a conflict arose over who had the authority to appoint the head of the Mongol Xukung banner, situated north of the Yellow River and Paot'ou. Following the death of the previous administrator, Prince Xu declared that he had taken control of the position. In response to a request from the local abbot, Prince Yun, acting in his capacity as chairman of the Mongolian Political Council, dismissed Xu. Xu then turned to Nanking through Suiyuan Provincial Chairman Fu Zuoyi, arguing that the central government held the authority to appoint heads of administrative units. In retaliation, Prince De dispatched troops to Xukung. On November 10, Fu presented a mediation proposal, which was rejected since it not only failed to acknowledge Shih's dismissal but also demanded the withdrawal of De's forces. De refused to pull back, further intensifying his hostility toward the Nanking government. In December, the Kwantung Army attempted to move Li's forces from eastern Chahar into the six Xun to the north of Kalgan, which serves as Chahar's granary. Following the Qin-Doihara agreement, Matsui Gennosuke from the Kalgan Special Service Agency secured a deal to separate these six districts from the southern region predominantly populated by Chinese; a Mongolian peace preservation corps was tasked with maintaining order in the northern area, while a Chinese corps was responsible for the south. During the discussions for an autonomous regime centered around Song Queyuan in North China in November 1935, Kwantung Army troops were concentrated around Gubeikou. To exert pressure on Song's rear, the Kwantung Army proposed replacing the Chinese peace preservation unit in the area north of Kalgan with Li Xuxin's army, which would establish this territory as its base.   The operation commenced on December 8. In a surprise attack just before dawn, Li captured Paochang. By December 12, despite facing strong Chinese resistance and the heaviest snowfall in sixty years, Li, aided by Kwantung Army planes disguised as those of the Manchukuo Airline Corporation, had taken control of Kuyuan. Further advances were halted by an order from Kwantung Army headquarters, and on December 13, it was reported that, had the operation not been stopped, Tokyo would have issued an imperial command. The operation had faced opposition from the Tientsin army, which feared it would weaken Song Queyuan's position just as they were informing Tokyo that the autonomy movement was going smoothly. Additionally, both Britain and the United States publicly expressed strong opposition to the Kwantung Army's involvement in the autonomy movement. However, the directive was ultimately prompted by the emperor's anger upon discovering that a unit of the Kwantung Army led by Colonel Matsui Takurö had advanced to Tolun to support Li's progress. Although Li's advance was halted, the operation undeniably contributed to the formation of the Hopei-Chahar Political Council.   Although the operation was halted, the Kwantung Army remained committed to its objectives. They contended that Li's army's advance into the six districts north of Kalgan was merely a peace preservation unit moving into territory within the truce line established by the Tanggu Agreement. Consequently, on December 29, they ordered Li to advance southward. Li peacefully occupied Changpei the following day and entered Shangtu on December 31. Manchukuo civil officials were appointed to oversee the six districts, and the currency of Manchukuo was introduced, although the existing tax system initially remained unchanged. The Kwantung Army allocated silver worth 6 million yuan to support administrative expenses. This outcome, known as the Eastern Chahar incident, marked a complete success for the Kwantung Army, which then redirected its focus toward Suiyuan Province. Each year, the Kwantung Army developed a secret plan for covert operations for the following year. The 1936 plan included strategies to secure air bases for routes connecting Europe and Asia, targeting Tsinghai and Sinkiang provinces, Outer Mongolia, Western Mongolia, and even remote areas of Ningxia province. In January 1936, staff officer Tanaka Ryūkichi formulated a document titled "Essentials of Policy Toward (Northwestern) Inner Mongolia." This document advocated for the establishment of a Mongolian military government to facilitate Japanese operations in northwestern Mongolia and suggested pushing Fu Tso-yi out of Suiyuan into Shansi province. Tanaka's proposals were incorporated into the final plan of the Kwantung Army, ultimately leading to the Suiyuan incident of November 1936. In February 1936, a meeting at Pailingmiao, where Prince De proposed the independence of Inner Mongolia, resulted in the departure of Prince So and several other Mongolian leaders from the coalition. They sought to establish a rival political council at Kueisui under the protection of Fu Zuoyi. By April, De and his supporters decided to form a military government at Tehua in Chahar, which was officially inaugurated in June as the Inner Mongolian government, headed by De with Li Shou-hsin as his deputy. This new government quickly signed a mutual assistance treaty with Manchukuo, and the emperor granted De the title of prince.   In July, at a conference in Tehua, Tanaka was appointed as the head of the Special Service Agency for Inner Mongolia with the mission of implementing the army's Intelligence Section plans. He traveled to Pingtiqüan alongside Chief of Staff Itagaki and Intelligence Chief Mutō Akira to propose a local anti-Communist agreement to Fu. After failing to convince Fu, he attempted to persuade Sun Tien-ying to form a puppet army but managed to recruit only a bandit from Suiyuan, Wang Ying. The February 26 mutiny in Tokyo heightened anti-Japanese sentiments in China, resulting in increased violence. By August, the construction of an airplane hangar in Paot'ou was halted due to riots by local Chinese residents. On August 13, a group of fifteen Japanese, led by Nakajima Manzo, was ambushed while delivering ammunition to a pro-Japanese leader who was shortly thereafter assassinated. Chinese soldiers from Wang Qingkuo's 70th Division carried out the attack, and tensions escalated as the arrival of ammunition and Japanese laborers in Kalgan prompted border villages to strengthen their defenses.   By late September, Tanaka's "Guidelines for the Execution of the Suiyuan Operation" received approval, with operations set to commence in early November. The plan evolved from a covert mission into a personal initiative by Tanaka, financed largely through funds from the Kwantung Army's secret services and profits from special trading in eastern Hopei. Tanaka claimed to have transported 600,000 yen to Tehua in October and later sent 200,000 yuan into Inner Mongolia, estimating total expenses at approximately 6 million yen. He acquired new weaponry from the disbanded Northeast Army and established three clandestine forces: Wang Ying led 500 men, including artillery; Qin Xiashan commanded 3,000 from Sun Tienying's army; and Chang Futang also led 3,000 specialized units. During strategic meetings, Tanaka dismissed proposals for unified command and refusing to integrate secret units into the Mongolian army. He advocated for the slogan "Overthrow Chiang Kai-shek," while Matsui managed to include "Independence for Inner Mongolia."   The Japanese had developed the entire battle strategy. The 1st Army, commanded by Li Xuxin, would serve as the left flank, while the 2nd Army, led by Demchugdongrub, would be positioned on the right. Wang Ying's forces were designated as the central force. Their initial targets would be Hongort, Xinghe, Tuchengzi, and Guisui city, followed by a division to seize Jinging, Baotou, and Hetao. On November 13, Prince Demchugdongrub's and Wang Ying's forces left Shandu in two columns to assault Xinghe and Hongort. By the 15th, 1,500 troops reached Hongort, where they engaged the 1st Cavalry Division led by Peng Yubin. The next day, Ryukichi Tanaka, Demchugdongrub's chief advisor, sent two cavalry brigades and one infantry brigade to capture the town, effectively overrunning its defenders. Meanwhile, Wang Ying dispatched a smaller group to secure Tuchengzi.   Fu Zuoyi established his headquarters in Jining that same day. After assessing the situation, he concluded that if the enemy secured Hongort, it would diminish his defenders' morale. Consequently, he launched a counterattack. Peng Yubin led a joint force of the 1st Cavalry Division and Dong Qiwu's 218th Brigade to confront around 400 of Wang Ying's men defending Hongort and Tuchengzi. By 7 AM on the 18th, Tuchengzi was reclaimed, and at 8:30 AM, the 1st Cavalry Division entered Hongort, charging through 500 of Wang Ying's soldiers. The struggle for Hongort persisted for over three days, resulting in nearly 1,000 casualties before Fu Zuoyi regained control.   As the tide shifted against the invaders, Fu Zuoyi initiated an offensive toward the Bailing Temple, the rear base of the enemy, well-stocked and defended by 3,000 men under Prince Demchugdongrub. Fu Zuoyi ordered the 2nd Cavalry Division, along with the 211th and 315th Brigades, the 21st Artillery Regiment, and a convoy of 20 trucks and 24 armored vehicles to assault the Bailing Temple as quickly as possible. Taking advantage of the Mongolian chaos, Fu Zuoyi's 35th Brigade executed a flanking maneuver west of the Bailing Temple amid a severe snowstorm.   At 1 AM on the 24th, the battle for the Bailing Temple commenced as the Chinese engaged the Mongolians for the fortified positions around the temple. From 2 to 4 AM, the Chinese advanced closer to the temple walls, facing artillery and machine-gun fire. They launched desperate frontal assaults against the city gates, suffering heavy losses. A fierce stalemate ensued, with Japanese aerial bombardments causing significant casualties to the Chinese forces. Fu Zuoyi subsequently ordered all armored vehicles to converge at the main city gate. Despite intense fire, the armored cars managed to breach the gate, allowing Chinese infantry to flood into the temple area. The resulting carnage within the temple walls led to 900 Mongol deaths, with 300 captured as the rest fled. The Chinese suffered 300 casualties but secured the strategically vital rear base, along with a substantial stockpile of provisions, including 500 barrels of petrol, 600 rifles, 10 machine guns, vehicles, and field guns. Following the devastating defeat at Bailing Temple, the invaders regrouped at Xilamuleng Temple. On the 28th, the Japanese sent 100 vehicles to transport 3,000 troops to prepare for a significant counteroffensive to recapture Bailing Temple. On the 29th, Wang Ying personally led 2,000 cavalry north of Shangdu to Taolin in an attempt to contain the enemy. However, after he left the bulk of his forces at Xilamuleng Temple, officers from the Grand Han Righteous Army secretly began negotiating to defect to the Chinese side, undermining the forces needed for the counterattack against Bailing Temple.   The counteroffensive commenced on December 2nd, with 10 armored vehicles and 1,000 Mongol troops leading the charge at 6 AM. They were pushed back by the heavily fortified 211th Brigade, which was well-supplied with machine guns and artillery. The following day, at 3 AM, the Mongols attempted a surprise attack but faced an ambush as they crept toward the temple. They incurred hundreds of casualties, with 230 men either captured or having defected. After this, the counterattack stalled, as the Mongol forces couldn't approach within 3 miles of the temple. Subsequently, the Chinese 2nd Cavalry Division launched a pincer maneuver, causing significant casualties among the invaders. By 9 AM, the enemy had suffered 500 casualties and was in retreat. At 7 PM, Fu Zuoyi ordered another counteroffensive. By the next morning, hundreds more had been lost, and several hundred soldiers were captured. With such heavy losses, the defense of Xilamuleng Temple weakened significantly, prompting more officers to defect to the Chinese. Late on the 4th, Fu Zuoyi assembled a force comprising two cavalry regiments, one infantry regiment, one artillery battalion, four armored vehicles, and a squadron of cars to launch a nighttime assault on Xilamuleng Temple.   Meanwhile, the 2nd Cavalry Division clashed with Wang Ying's cavalry 30 miles northeast of Wulanhua. Wang Ying's 2,000 cavalry had been raiding nearby villages to create diversions, drawing enemy forces away from the Bailing-Xilamuleng theater. By the 9th, Wang Ying's cavalry were encircled in Xiaobei, where they were nearly annihilated, with Wang escaping with around a hundred guards toward Changpei. On the 7th, some Grand Han Righteous Army officers set in motion plans to defect to the Chinese side. Early on the 9th, these officers led their men to invade the residence of Japanese advisors, killing all 27 Japanese officers under Colonel Obama. Simultaneously, Fu Zuoyi's forces executed a flanking maneuver against the Xilamuleng Temple amidst the chaos. With mass defections, the Chinese forces surged into the temple area, resulting in the invader army disintegrating in confusion and surrender. After seizing the temple, the invaders were routed, their lines of communication severed, and only isolated pockets continued to resist. Taking advantage of the confusion, Fu Zuoyi launched simultaneous attacks, attempting to capture Shangdu. However, Yan Xishan sent him a telegram, ordering him to halt, stating that Shangdu fell under the jurisdiction of Shanxi and not Suiyuan.   In response to the loss, Tanaka planned a counteroffensive with Qin's troops, but Chiang kai-shek commanded a strong defense of Pailingmiao, successfully outmaneuvering Tanaka's strategies. The resurgence of Chinese forces led to the disintegration of Qin's troops, who revolted and eventually joined the Nationalist army. The Kwantung Army aimed to redeploy its forces for recovery but faced opposition from Tokyo, which criticized the situation. After Chiang kai-shek was kidnapped by Zhang Xueliang on December 12, Tanaka and Prince De seized the opportunity to reassess their strategy. Ultimately, the Kwantung Army decided to abandon efforts to reclaim Pailingmiao, marking the official end of hostilities on December 21. The Suiyuan incident ultimately strengthened Chinese resolve against Japan and increased international distrust.   The defeat of Japan's proxy forces inspired many Chinese to advocate for a more vigorous resistance against the Japanese. The triumph in Suiyuan was celebrated throughout China and surprised the international media, marking the first occasion where the Chinese army successfully halted a Japanese unit. Delegations traveled from as distant as southern Chinese provinces to encourage the defenders to continue their fight. Captured Japanese weapons and equipment served as proof of Japan's involvement in the conflict, despite Japan's Foreign Minister Hachirō Arita claiming that "Japan was not involved in this conflict in Suiyuan at all." After his defeat, Prince Demchugdongrub and his Inner Mongolian troops retreated to northern Chahar, where he had to reconstruct his army due to significant losses. The Japanese implemented new regulations for the Mongolian Army to enhance its effectiveness, and efforts to recruit new soldiers commenced.   I would like to take this time to remind you all that this podcast is only made possible through the efforts of Kings and Generals over at Youtube. Please go subscribe to Kings and Generals over at Youtube and to continue helping us produce this content please check out www.patreon.com/kingsandgenerals. If you are still hungry after that, give my personal channel a look over at The Pacific War Channel at Youtube, it would mean a lot to me. More incidents and more battles to seize territory raged in North China. However things did not go according to plan for the Japanese and their puppets. The tides had turned, and now a more angry and invigorating China would begin lashing out against the encroachment. It was only a matter of time before a full blown war was declared. 

Alive and Active Life
Strategies To Be More Like Jesus

Alive and Active Life

Play Episode Listen Later May 19, 2025 21:46


In our last article/podcast, A Plan To Be More Like Jesus, we laid out a reasonable plan using twenty-five helpful action points to keep you matched up with Scripture. You've likely formed many plans over the years with strategies to carry them out. Subsequently, it makes sense to develop a plan and long-term strategies to be more like Jesus. Read More ... For more resources and tools that inspire and equip you to live well using God's Word in practical ways each day, visit the Alive and Active Life website.

I Hate Numbers
Cloud Accounting: What It Is and Why Your Business Needs It

I Hate Numbers

Play Episode Listen Later May 18, 2025 10:02


Transforming Business Finance ManagementCloud accounting is changing how business owners manage their finances. Accordingly, we want to explain why this shift matters for freelancers and entrepreneurs who often avoid financial management until it's too late. Furthermore, understanding this technology can save you time, money, and stress in running your business.What Exactly Is Cloud Accounting?Firstly, cloud accounting means using online software to handle your business finances in real time. Additionally, it covers everything from invoicing and expense tracking to financial reporting. Unlike traditional methods, cloud accounting gives you access from anywhere—your phone, laptop, or tablet. Therefore, you can check your financial position while sitting in your garden or meeting clients at a café.Key Benefits For Your BusinessTime Savings That Convert To MoneyBecause cloud accounting automates many tasks, you can save several hours each week. For instance, our client Sandra (name changed) previously spent Sunday mornings entering receipts and chasing payments. Consequently, after switching to cloud accounting, she saved 3-4 hours weekly. Moreover, at £20 per hour, this represents significant savings over a quarter—not to mention getting paid faster through electronic invoicing.Fewer Costly MistakesCertainly, everyone makes errors occasionally. However, cloud accounting significantly reduces these problems. While spreadsheets invite formula errors and duplicate entries, cloud systems flag issues in real time. Thus, you're not "walking a financial tightrope with a blindfold."Clear Financial VisibilityRunning a business without seeing your finances clearly is like driving with a frosted windscreen. Nevertheless, cloud accounting solves this problem through intuitive dashboards and reports. Hence, you can instantly view bank balances, outstanding invoices, and expense patterns. Specifically, this visibility leads to better decision-making and fewer financial surprises.Easy To Implement Despite Common FearsAlthough many fear new technology, cloud accounting platforms like Xero are designed for non-accountants. Besides, most systems offer straightforward setup processes. Once configured, you can: Connect your bank accounts for automatic updates Upload receipts by simply taking a photo Set automatic reminders for overdue invoicesOverall, it's like having a digital finance assistant that never complains or takes holidays.The Cost Of Avoiding Modern Financial ToolsContrarily, sticking with outdated methods can lead to serious problems: Unpredictable cash flow Delayed invoicing Uncollected payments Surprise tax billsUndoubtedly, these issues amount to what we call "silent financial sabotage." Regardless of how busy you are, neglecting your financial systems ultimately undermines your business success.Getting Started Without The HeadacheTransitioning to cloud accounting doesn't need to be painful. Subsequently, we recommend this simple approach: Select appropriate software (we recommend Xero) Learn the basics of navigation Set up automatic bank feeds Establish a weekly 30-minute routineSince consistency matters more than perfection, small regular habits beat...

Critical Mass Radio Show
Critical Mass Business Talk Show: Ric Franzi Interviews Ana Almada, CEO of DKN Hotels (Episode 1589)

Critical Mass Radio Show

Play Episode Listen Later May 15, 2025 24:53


Drawing on years of hospitality industry expertise, Ms. Almada excels as the Chief Executive Officer of DKN Hotels. Since joining the organization in 1998, she has held various roles, including Vice President, Regional Director, General Manager, and Assistant General Manager. In this current capacity, she oversees all personnel, ensuring they have what they need to reach their goals. Additionally, Ms. Almada conducts site visits, manages growth strategies, and collaborates with team members to motivate and inspire them. An expert in her field, Ms. Almada earned a bachelor's degree in tourism and hotel management from Universidade Anhembi Morumbi before joining DKN Hotels as a front desk clerk. Subsequently, she expanded her professional knowledge by completing an MBA with emphasis in leadership and management from the University of San Diego. In conjunction with her work, she is aligned with Vistage Worldwide, Inc., a chief executive officer coaching and peer advisory organization through which she has dedicated herself to continued improvement and mentorship since 2009. Likewise, Ms. Almada has dedicated herself to her community through the Girl Scouts from a young age and the Woman's Leadership Council. In light of her professional achievements, Ms. Almada has received numerous awards and nominations for her dedication to industry excellence. Most recently Ana has been recognized as one of HOTEL MANAGEMENT Magazine's 2025 Forty Over 40! This distinction celebrates exceptional leaders who exemplify dedication, innovation, and influence within the hospitality industry. Ana's unwavering commitment and passion continue to inspire us all, shaping a legacy of excellence here at DKN Hotels.  DKN Hotels was also named the Best Place to Work in Orange County in 2017 and received the Nation's Top Workplaces through USA Today in 2024. While her career has been filled with highlights, she takes the most pride in developing DKN Hotels' company culture and establishing new hotels. Though hard work and dedication have brought her far in her career, she credits her success to the collective efforts of everyone she works with. Her team generously gives their time, knowledge, and patience to fulfill the company's desire to make a difference. She also notes that education, research, and drive have kept her on the path to success. Looking toward the future, Ms. Almada intends to ensure that DKN continues to develop and manage their portfolio of hotels, expands the business, extend its management services to other hoteliers, and inspire and develop more passionate individuals in the hospitality industry. -- Critical Mass Business Talk Show is Orange County, CA's longest-running business talk show, focused on offering value and insight to middle-market business leaders in the OC and beyond. Hosted by Ric Franzi, business partner at REF Orange County.

Joy Stephen's Canada Immigration Podcast
Canada Immigration LMIA-Exempt Work Permit figures for C12,  (Intra-Company Transferees Airline personnel (station managers)) in  2022, for Total visas issued by IRCC.

Joy Stephen's Canada Immigration Podcast

Play Episode Listen Later May 14, 2025 3:30


Canada Immigration LMIA-Exempt Work Permit figures for C12,  (Intra-Company Transferees Airline personnel (station managers)) in  2022, for Total visas issued by IRCC.  Good day ladies and gentlemen, this is IRC news, and I am Joy Stephen, an authorized Canadian Immigration practitioner bringing out this Canada Work Permit application data specific to LMIA work permits or employer driven work permits or LMIA exempt work permits for multiple years based on your country of Citizenship. I am coming to you from the Polinsys studios in Cambridge, Ontario   In 2022, a total of 18425 LMIA-Exempt Work Permits were issued by IRCC, under C12, (Intra-Company Transferees Airline personnel (station managers)).  If you have an interest in gaining assistance with Work Permits based on your country of Citizenship, or should you require guidance post-selection, we extend a warm invitation to connect with us via https://myar.me/c. We strongly recommend attending our complimentary Zoom resource meetings conducted every Thursday. We kindly request you to carefully review the available resources. Subsequently, should any queries arise, our team of Canadian Authorized Representatives is readily available to address your concerns during the weekly AR's Q&A session held on Fridays. You can find the details for both these meetings at https://myar.me/zoom. Our dedicated team is committed to providing you with professional assistance in navigating the immigration process. Additionally, IRCNews offers valuable insights on selecting a qualified representative to advocate on your behalf with the Canadian Federal or Provincial governments, accessible at https://ircnews.ca/consultant 

Joy Stephen's Canada Immigration Podcast
Canada Immigration LMIA-Exempt Work Permit figures for C12, (Intra-Company Transferees Airline personnel (station managers)) in 2021, for visas issued without a Provincial attachment.

Joy Stephen's Canada Immigration Podcast

Play Episode Listen Later May 14, 2025 3:28


Canada Immigration LMIA-Exempt Work Permit figures for C12, (Intra-Company Transferees Airline personnel (station managers)) in 2021, for visas issued without a Provincial attachment.  Good day ladies and gentlemen, this is IRC news, and I am Joy Stephen, an authorized Canadian Immigration practitioner bringing out this Canada Work Permit application data specific to LMIA work permits or employer driven work permits or LMIA exempt work permits for multiple years based on your country of Citizenship. I am coming to you from the Polinsys studios in Cambridge, Ontario  In 2021, a total of 5 LMIA-Exempt Work Permits were approved without a provincial attachment, under C12, (Intra-Company Transferees Airline personnel (station managers)).   If you have an interest in gaining assistance with Work Permits based on your country of Citizenship, or should you require guidance post-selection, we extend a warm invitation to connect with us via https://myar.me/c. We strongly recommend attending our complimentary Zoom resource meetings conducted every Thursday. We kindly request you to carefully review the available resources. Subsequently, should any queries arise, our team of Canadian Authorized Representatives is readily available to address your concerns during the weekly AR's Q&A session held on Fridays. You can find the details for both these meetings at https://myar.me/zoom. Our dedicated team is committed to providing you with professional assistance in navigating the immigration process. Additionally, IRCNews offers valuable insights on selecting a qualified representative to advocate on your behalf with the Canadian Federal or Provincial governments, accessible at https://ircnews.ca/consultant  

Joy Stephen's Canada Immigration Podcast
Canada Immigration LMIA-Exempt Work Permit figures for C12, (Intra-Company Transferees Airline personnel (station managers)) in 2022, for visas issued without a Provincial attachment.

Joy Stephen's Canada Immigration Podcast

Play Episode Listen Later May 14, 2025 3:26


Canada Immigration LMIA-Exempt Work Permit figures for C12, (Intra-Company Transferees Airline personnel (station managers)) in 2022, for visas issued without a Provincial attachment.  Good day ladies and gentlemen, this is IRC news, and I am Joy Stephen, an authorized Canadian Immigration practitioner bringing out this Canada Work Permit application data specific to LMIA work permits or employer driven work permits or LMIA exempt work permits for multiple years based on your country of Citizenship. I am coming to you from the Polinsys studios in Cambridge, Ontario   In 2022, a total of 20 LMIA-Exempt Work Permits were approved without a provincial attachment, under C12, (Intra-Company Transferees Airline personnel (station managers)).   If you have an interest in gaining assistance with Work Permits based on your country of Citizenship, or should you require guidance post-selection, we extend a warm invitation to connect with us via https://myar.me/c. We strongly recommend attending our complimentary Zoom resource meetings conducted every Thursday. We kindly request you to carefully review the available resources. Subsequently, should any queries arise, our team of Canadian Authorized Representatives is readily available to address your concerns during the weekly AR's Q&A session held on Fridays. You can find the details for both these meetings at https://myar.me/zoom. Our dedicated team is committed to providing you with professional assistance in navigating the immigration process. Additionally, IRCNews offers valuable insights on selecting a qualified representative to advocate on your behalf with the Canadian Federal or Provincial governments, accessible at https://ircnews.ca/consultant 

Joy Stephen's Canada Immigration Podcast
Canada Immigration LMIA-Exempt Work Permit figures for C12, (Intra-Company Transferees Airline personnel (station managers)) in 2023, for visas issued without a Provincial attachment.

Joy Stephen's Canada Immigration Podcast

Play Episode Listen Later May 14, 2025 3:27


Canada Immigration LMIA-Exempt Work Permit figures for C12, (Intra-Company Transferees Airline personnel (station managers)) in 2023, for visas issued without a Provincial attachment.  Good day ladies and gentlemen, this is IRC news, and I am Joy Stephen, an authorized Canadian Immigration practitioner bringing out this Canada Work Permit application data specific to LMIA work permits or employer driven work permits or LMIA exempt work permits for multiple years based on your country of Citizenship. I am coming to you from the Polinsys studios in Cambridge, Ontario   In 2023, a total of 5 LMIA-Exempt Work Permits were approved without a provincial attachment, under C12, (Intra-Company Transferees Airline personnel (station managers)).   If you have an interest in gaining assistance with Work Permits based on your country of Citizenship, or should you require guidance post-selection, we extend a warm invitation to connect with us via https://myar.me/c. We strongly recommend attending our complimentary Zoom resource meetings conducted every Thursday. We kindly request you to carefully review the available resources. Subsequently, should any queries arise, our team of Canadian Authorized Representatives is readily available to address your concerns during the weekly AR's Q&A session held on Fridays. You can find the details for both these meetings at https://myar.me/zoom. Our dedicated team is committed to providing you with professional assistance in navigating the immigration process. Additionally, IRCNews offers valuable insights on selecting a qualified representative to advocate on your behalf with the Canadian Federal or Provincial governments, accessible at https://ircnews.ca/consultant 

Joy Stephen's Canada Immigration Podcast
Canada Immigration LMIA-Exempt Work Permit figures for C12,  (Intra-Company Transferees Airline personnel (station managers)) in  2021, for Total visas issued by IRCC.

Joy Stephen's Canada Immigration Podcast

Play Episode Listen Later May 14, 2025 3:27


Canada Immigration LMIA-Exempt Work Permit figures for C12,  (Intra-Company Transferees Airline personnel (station managers)) in  2021, for Total visas issued by IRCC.  Good day ladies and gentlemen, this is IRC news, and I am Joy Stephen, an authorized Canadian Immigration practitioner bringing out this Canada Work Permit application data specific to LMIA work permits or employer driven work permits or LMIA exempt work permits for multiple years based on your country of Citizenship. I am coming to you from the Polinsys studios in Cambridge, Ontario   In 2021, a total of 4190 LMIA-Exempt Work Permits were issued by IRCC, under C12, (Intra-Company Transferees Airline personnel (station managers)).  If you have an interest in gaining assistance with Work Permits based on your country of Citizenship, or should you require guidance post-selection, we extend a warm invitation to connect with us via https://myar.me/c. We strongly recommend attending our complimentary Zoom resource meetings conducted every Thursday. We kindly request you to carefully review the available resources. Subsequently, should any queries arise, our team of Canadian Authorized Representatives is readily available to address your concerns during the weekly AR's Q&A session held on Fridays. You can find the details for both these meetings at https://myar.me/zoom. Our dedicated team is committed to providing you with professional assistance in navigating the immigration process. Additionally, IRCNews offers valuable insights on selecting a qualified representative to advocate on your behalf with the Canadian Federal or Provincial governments, accessible at https://ircnews.ca/consultant 

Joy Stephen's Canada Immigration Podcast
Canada Immigration LMIA-Exempt Work Permit figures for C12,  (Intra-Company Transferees Airline personnel (station managers)) in  2023, for Total visas issued by IRCC.

Joy Stephen's Canada Immigration Podcast

Play Episode Listen Later May 14, 2025 3:29


Canada Immigration LMIA-Exempt Work Permit figures for C12,  (Intra-Company Transferees Airline personnel (station managers)) in  2023, for Total visas issued by IRCC.  Good day ladies and gentlemen, this is IRC news, and I am Joy Stephen, an authorized Canadian Immigration practitioner bringing out this Canada Work Permit application data specific to LMIA work permits or employer driven work permits or LMIA exempt work permits for multiple years based on your country of Citizenship. I am coming to you from the Polinsys studios in Cambridge, Ontario   In 2023, a total of 2645 LMIA-Exempt Work Permits were issued by IRCC, under C12, (Intra-Company Transferees Airline personnel (station managers)).    If you have an interest in gaining assistance with Work Permits based on your country of Citizenship, or should you require guidance post-selection, we extend a warm invitation to connect with us via https://myar.me/c. We strongly recommend attending our complimentary Zoom resource meetings conducted every Thursday. We kindly request you to carefully review the available resources. Subsequently, should any queries arise, our team of Canadian Authorized Representatives is readily available to address your concerns during the weekly AR's Q&A session held on Fridays. You can find the details for both these meetings at https://myar.me/zoom. Our dedicated team is committed to providing you with professional assistance in navigating the immigration process. Additionally, IRCNews offers valuable insights on selecting a qualified representative to advocate on your behalf with the Canadian Federal or Provincial governments, accessible at https://ircnews.ca/consultant  

Joy Stephen's Canada Immigration Podcast
Canada Immigration LMIA-Exempt Work Permit figures for C32, (Research exemption codes Educational co-op – post-secondary) in 2021, for Total visas issued by IRCC.

Joy Stephen's Canada Immigration Podcast

Play Episode Listen Later May 12, 2025 3:28


Canada Immigration LMIA-Exempt Work Permit figures for C32, (Research exemption codes Educational co-op – post-secondary) in 2021, for Total visas issued by IRCC.  Good day ladies and gentlemen, this is IRC news, and I am Joy Stephen, an authorized Canadian Immigration practitioner bringing out this Canada Work Permit application data specific to LMIA work permits or employer driven work permits or LMIA exempt work permits for multiple years based on your country of Citizenship. I am coming to you from the Polinsys studios in Cambridge, Ontario  In 2021, a total of 25 LMIA-Exempt Work Permits were issued by IRCC, under C32, (Research exemption codes Educational co-op – post-secondary).  If you have an interest in gaining assistance with Work Permits based on your country of Citizenship, or should you require guidance post-selection, we extend a warm invitation to connect with us via https://myar.me/c. We strongly recommend attending our complimentary Zoom resource meetings conducted every Thursday. We kindly request you to carefully review the available resources. Subsequently, should any queries arise, our team of Canadian Authorized Representatives is readily available to address your concerns during the weekly AR's Q&A session held on Fridays. You can find the details for both these meetings at https://myar.me/zoom. Our dedicated team is committed to providing you with professional assistance in navigating the immigration process. Additionally, IRCNews offers valuable insights on selecting a qualified representative to advocate on your behalf with the Canadian Federal or Provincial governments, accessible at https://ircnews.ca/consulta 

Joy Stephen's Canada Immigration Podcast
Canada Immigration LMIA-Exempt Work Permit figures for C32, (Research exemption codes Educational co-op – post-secondary) in 2023 for the province/territory of British Columbia.

Joy Stephen's Canada Immigration Podcast

Play Episode Listen Later May 12, 2025 3:26


Canada Immigration LMIA-Exempt Work Permit figures for C32, (Research exemption codes Educational co-op – post-secondary) in 2023 for the province/territory of British Columbia. Good day ladies and gentlemen, this is IRC news, and I am Joy Stephen, an authorized Canadian Immigration practitioner bringing out this Canada Work Permit application data specific to LMIA work permits or employer driven work permits or LMIA exempt work permits for multiple years based on your country of Citizenship. I am coming to you from the Polinsys studios in Cambridge, Ontario   The Province or Territory of British Columbia accepted 5 LMIA-Exempt Work Permits in 2023. under C32, (Research exemption codes Educational co-op – post-secondary).  To delve into the history of news in British Columbia, follow this link: https://myar.me/tag/bc  If you have an interest in gaining comprehensive insights into the Canadian Federal Spouses and Partners sponsorship program or other Canadian Federal or Provincial Immigration programs, or should you require guidance post-selection, we extend a warm invitation to connect with us via https://myar.me/c.  We strongly recommend attending our complimentary Zoom resource meetings conducted every Thursday. We kindly request you to carefully review the available resources. Subsequently, should any queries arise, our team of Canadian Authorized Representatives is readily available to address your concerns during the weekly AR's Q&A session held on Fridays. You can find the details for both these meetings at https://myar.me/zoom.  Our dedicated team is committed to providing you with professional assistance in navigating the immigration process. Additionally, IRCNews offers valuable insights on selecting a qualified representative to advocate on your behalf with the Canadian Federal or Provincial governments, accessible at https://ircnews.ca/consultant. 

Joy Stephen's Canada Immigration Podcast
Canada Immigration LMIA-Exempt Work Permit figures for C32, (Research exemption codes Educational co-op – post-secondary) in 2022, for visas issued without a Provincial attachment.

Joy Stephen's Canada Immigration Podcast

Play Episode Listen Later May 12, 2025 3:28


Canada Immigration LMIA-Exempt Work Permit figures for C32, (Research exemption codes Educational co-op – post-secondary) in 2022, for visas issued without a Provincial attachment.  Good day ladies and gentlemen, this is IRC news, and I am Joy Stephen, an authorized Canadian Immigration practitioner bringing out this Canada Work Permit application data specific to LMIA work permits or employer driven work permits or LMIA exempt work permits for multiple years based on your country of Citizenship. I am coming to you from the Polinsys studios in Cambridge, Ontario    In 2022, a total of 55 LMIA-Exempt Work Permits were approved without a provincial attachment, under C32, (Research exemption codes Educational co-op – post-secondary).  If you have an interest in gaining assistance with Work Permits based on your country of Citizenship, or should you require guidance post-selection, we extend a warm invitation to connect with us via https://myar.me/c. We strongly recommend attending our complimentary Zoom resource meetings conducted every Thursday. We kindly request you to carefully review the available resources. Subsequently, should any queries arise, our team of Canadian Authorized Representatives is readily available to address your concerns during the weekly AR's Q&A session held on Fridays. You can find the details for both these meetings at https://myar.me/zoom. Our dedicated team is committed to providing you with professional assistance in navigating the immigration process. Additionally, IRCNews offers valuable insights on selecting a qualified representative to advocate on your behalf with the Canadian Federal or Provincial governments, accessible at https://ircnews.ca/consulta 

Joy Stephen's Canada Immigration Podcast
Canada Immigration LMIA-Exempt Work Permit figures for C32, (Research exemption codes Educational co-op – post-secondary) in 2023, for visas issued without a Provincial attachment.

Joy Stephen's Canada Immigration Podcast

Play Episode Listen Later May 12, 2025 3:29


Canada Immigration LMIA-Exempt Work Permit figures for C32, (Research exemption codes Educational co-op – post-secondary) in 2023, for visas issued without a Provincial attachment.  Good day ladies and gentlemen, this is IRC news, and I am Joy Stephen, an authorized Canadian Immigration practitioner bringing out this Canada Work Permit application data specific to LMIA work permits or employer driven work permits or LMIA exempt work permits for multiple years based on your country of Citizenship. I am coming to you from the Polinsys studios in Cambridge, Ontario    In 2023, a total of 20 LMIA-Exempt Work Permits were approved without a provincial attachment, under C32, (Research exemption codes Educational co-op – post-secondary).   If you have an interest in gaining assistance with Work Permits based on your country of Citizenship, or should you require guidance post-selection, we extend a warm invitation to connect with us via https://myar.me/c. We strongly recommend attending our complimentary Zoom resource meetings conducted every Thursday. We kindly request you to carefully review the available resources. Subsequently, should any queries arise, our team of Canadian Authorized Representatives is readily available to address your concerns during the weekly AR's Q&A session held on Fridays. You can find the details for both these meetings at https://myar.me/zoom. Our dedicated team is committed to providing you with professional assistance in navigating the immigration process. Additionally, IRCNews offers valuable insights on selecting a qualified representative to advocate on your behalf with the Canadian Federal or Provincial governments, accessible at https://ircnews.ca/consulta 

Joy Stephen's Canada Immigration Podcast
Canada Immigration LMIA-Exempt Work Permit figures for C32, (Research exemption codes Educational co-op – post-secondary) in 2023 for the province/territory of Quebec.

Joy Stephen's Canada Immigration Podcast

Play Episode Listen Later May 12, 2025 3:25


Canada Immigration LMIA-Exempt Work Permit figures for C32, (Research exemption codes Educational co-op – post-secondary) in 2023 for the province/territory of Quebec.  Good day ladies and gentlemen, this is IRC news, and I am Joy Stephen, an authorized Canadian Immigration practitioner bringing out this Canada Work Permit application data specific to LMIA work permits or employer driven work permits or LMIA exempt work permits for multiple years based on your country of Citizenship. I am coming to you from the Polinsys studios in Cambridge, Ontario The Province or Territory of Quebec accepted 5 LMIA-Exempt Work Permits in 2023. Under C32, (Research exemption codes Educational co-op – post-secondary). Access archived news articles from Quebec via this link: https://myar.me/tag/qc  If you are interested in gaining comprehensive insights into the Federal Startup Business Program or other Canadian Federal or Provincial Immigration programs, or if you need guidance post-selection, we cordially invite you to connect with us via https://myar.me/c.  We highly recommend attending our complimentary Zoom resource meetings held every Thursday. We kindly request you to thoroughly review the available resources. Subsequently, if you have any questions, our team of Canadian Authorized Representatives is readily available to address your concerns during the weekly AR's Q&A session on Fridays. You can find details for both these meetings at https://myar.me/zoom.  Our dedicated team is committed to providing professional assistance throughout your immigration journey. Furthermore, IRCNews offers valuable insights on selecting a qualified representative to advocate on your behalf with the Canadian Federal or Provincial governments, accessible at https://ircnews.ca/consultant.  

Joy Stephen's Canada Immigration Podcast
Canada Immigration LMIA-Exempt Work Permit figures for C32, (Research exemption codes Educational co-op – post-secondary) in 2022, for Total visas issued by IRCC.

Joy Stephen's Canada Immigration Podcast

Play Episode Listen Later May 12, 2025 3:26


Canada Immigration LMIA-Exempt Work Permit figures for C32, (Research exemption codes Educational co-op – post-secondary) in 2022, for Total visas issued by IRCC.  Good day ladies and gentlemen, this is IRC news, and I am Joy Stephen, an authorized Canadian Immigration practitioner bringing out this Canada Work Permit application data specific to LMIA work permits or employer driven work permits or LMIA exempt work permits for multiple years based on your country of Citizenship. I am coming to you from the Polinsys studios in Cambridge, Ontario   In 2022, a total of 95 LMIA-Exempt Work Permits were issued by IRCC, under C32, (Research exemption codes Educational co-op – post-secondary).   If you have an interest in gaining assistance with Work Permits based on your country of Citizenship, or should you require guidance post-selection, we extend a warm invitation to connect with us via https://myar.me/c. We strongly recommend attending our complimentary Zoom resource meetings conducted every Thursday. We kindly request you to carefully review the available resources. Subsequently, should any queries arise, our team of Canadian Authorized Representatives is readily available to address your concerns during the weekly AR's Q&A session held on Fridays. You can find the details for both these meetings at https://myar.me/zoom. Our dedicated team is committed to providing you with professional assistance in navigating the immigration process. Additionally, IRCNews offers valuable insights on selecting a qualified representative to advocate on your behalf with the Canadian Federal or Provincial governments, accessible at https://ircnews.ca/consulta 

Joy Stephen's Canada Immigration Podcast
Canada Immigration LMIA-Exempt Work Permit figures for C32, (Research exemption codes Educational co-op – post-secondary) in 2023, for Total visas issued by IRCC.

Joy Stephen's Canada Immigration Podcast

Play Episode Listen Later May 12, 2025 3:27


Canada Immigration LMIA-Exempt Work Permit figures for C32, (Research exemption codes Educational co-op – post-secondary) in 2023, for Total visas issued by IRCC.  Good day ladies and gentlemen, this is IRC news, and I am Joy Stephen, an authorized Canadian Immigration practitioner bringing out this Canada Work Permit application data specific to LMIA work permits or employer driven work permits or LMIA exempt work permits for multiple years based on your country of Citizenship. I am coming to you from the Polinsys studios in Cambridge, Ontario   In 2023, a total of 55 LMIA-Exempt Work Permits were issued by IRCC, under C32, (Research exemption codes Educational co-op – post-secondary). If you have an interest in gaining assistance with Work Permits based on your country of Citizenship, or should you require guidance post-selection, we extend a warm invitation to connect with us via https://myar.me/c. We strongly recommend attending our complimentary Zoom resource meetings conducted every Thursday. We kindly request you to carefully review the available resources. Subsequently, should any queries arise, our team of Canadian Authorized Representatives is readily available to address your concerns during the weekly AR's Q&A session held on Fridays. You can find the details for both these meetings at https://myar.me/zoom. Our dedicated team is committed to providing you with professional assistance in navigating the immigration process. Additionally, IRCNews offers valuable insights on selecting a qualified representative to advocate on your behalf with the Canadian Federal or Provincial governments, accessible at https://ircnews.ca/consulta 

Joy Stephen's Canada Immigration Podcast
Canada Immigration LMIA-Exempt Work Permit figures for C32, (Research exemption codes Educational co-op – post-secondary) in 2021, for visas issued without a Provincial attachment.

Joy Stephen's Canada Immigration Podcast

Play Episode Listen Later May 12, 2025 3:31


Canada Immigration LMIA-Exempt Work Permit figures for C32, (Research exemption codes Educational co-op – post-secondary) in 2021, for visas issued without a Provincial attachment.  Good day ladies and gentlemen, this is IRC news, and I am Joy Stephen, an authorized Canadian Immigration practitioner bringing out this Canada Work Permit application data specific to LMIA work permits or employer driven work permits or LMIA exempt work permits for multiple years based on your country of Citizenship. I am coming to you from the Polinsys studios in Cambridge, Ontario  In 2021, a total of 15 LMIA-Exempt Work Permits were approved without a provincial attachment, under C32, (Research exemption codes Educational co-op – post-secondary).    If you have an interest in gaining assistance with Work Permits based on your country of Citizenship, or should you require guidance post-selection, we extend a warm invitation to connect with us via https://myar.me/c. We strongly recommend attending our complimentary Zoom resource meetings conducted every Thursday. We kindly request you to carefully review the available resources. Subsequently, should any queries arise, our team of Canadian Authorized Representatives is readily available to address your concerns during the weekly AR's Q&A session held on Fridays. You can find the details for both these meetings at https://myar.me/zoom. Our dedicated team is committed to providing you with professional assistance in navigating the immigration process. Additionally, IRCNews offers valuable insights on selecting a qualified representative to advocate on your behalf with the Canadian Federal or Provincial governments, accessible at https://ircnews.ca/consulta 

Journal of Clinical Oncology (JCO) Podcast
Pembrolizumab and Bevacizumab for Melanoma Brain Metastases

Journal of Clinical Oncology (JCO) Podcast

Play Episode Listen Later May 8, 2025 23:59


Host Dr. Davide Soldato and guest Dr. Harriet Kluger discuss the JCO article "Phase II Trial of Pembrolizumab in Combination With Bevacizumab for Untreated Melanoma Brain Metastases." Transcript The guest on this podcast episode has no disclosures to declare. Dr. Davide Soldato Hello and welcome to JCO After Hours, the podcast where we sit down with authors from some of the latest articles published in the Journal of Clinical Oncology. I am your host, Dr. Davide Soldato, Medical Oncologist at Ospedale San Martino in Genoa, Italy. Today, we are joined by JCO author Dr. Harriet Kluger. Dr. Kluger is a professor of medicine at Yale School of Medicine, Director of the Yale SPORE in Skin Cancer, and an internationally recognized expert in immuno-oncology for melanoma and renal cell carcinoma. She leads early-phase and translational trials that pair novel immunotherapies with predictive biomarkers to personalized care. Today, Dr. Kluger and I will be discussing the article titled "Phase 2 Trial of Pembrolizumab in Combination with Bevacizumab for Untreated Melanoma Brain Metastases." In this study, Dr. Kluger and colleagues evaluated four cycles of pembrolizumab plus the anti-VEGF antibody bevacizumab followed by pembrolizumab maintenance in patients with asymptomatic non-hemorrhagic melanoma brain metastases that had not previously received PD-1 therapy. Thank you for speaking with us, Dr. Kluger. Dr. Harriet Kluger Thank you for inviting me. The pleasure is really all mine. Dr. Davide Soldato So to kick off our podcast, I just wanted to ask if you could outline a little bit the biological and clinical rationale that led you to test this type of combination for patients with untreated brain metastases from metastatic melanoma. Dr. Harriet Kluger Back in approximately 2012, patients who had untreated brain metastases were excluded from all clinical trials. So by untreated, I mean brain metastases that had not received local therapy such as surgery or radiation. The reason for it was primarily because there was this fear that big molecules wouldn't penetrate brain lesions because they can't pass the blood-brain barrier. Turns out that the blood-brain barrier within a tumor is somewhat leaky and drugs sometimes can get in there. When PD-1 inhibitors were first identified as the next blockbuster class of drugs, we decided to conduct a phase 2 clinical trial of pembrolizumab monotherapy in patients with untreated brain metastases. We actually did it also in lung cancer, and we could talk about that later on. Responses were seen. The responses in the brain and the body were similar. They were concordant in melanoma patients. Now, at approximately that time, also another study was done by the Australian group by Dr. Georgina Long, where they did a randomized trial where patients who didn't require immediate steroid therapy received either nivolumab alone or nivolumab with ipilimumab, and the combination arm was substantially superior. Subsequently, also, Bristol Myers Squibb also conducted a large phase 2 multicenter trial of ipilimumab and nivolumab in patients with untreated brain metastases. And there, once again, they saw that the responses in the brain were similar to the responses in the body. Now, somewhere along the line there, we completed our anti-PD-1 monotherapy trial. And when we looked at our data, we still didn't have the data on ipilimumab and nivolumab. And our question was, “Well, how can we do better?” Just as we're always trying to do better. We saw two really big problems. One was that patients had a lot of perilesional edema. And the other one was that we were struggling with radiation necrosis in lesions that were previously Gamma Knifed. The instance of radiation necrosis was in excess of 30%. So the rationale behind this study was that if we added bevacizumab, maybe we could treat those patients who had some edema, not requiring steroids, but potentially get them on study, get that PD-1 inhibitor going, and also prevent subsequent radiation necrosis. And that was the main rationale behind the study. We had also done some preclinical work in mouse models of melanoma brain metastases and in an in vitro blood-brain barrier model where we showed that bevacizumab, or anti-VEGF, really tightens up those leaky basement membranes and therefore would be very likely to decrease the edema. Dr. Davide Soldato Thank you very much for putting in context the combination. So this was a phase 2 trial, and you included patients who had at least one lesion, and you wanted lesions that were behind 5 and 20 millimeters. Patients could be included also if the brain metastasis was higher in dimension than 20 millimeters, but it had to be treated, and it was then excluded from the evaluation of the primary objective of the trial. So regarding, a little bit, these characteristics, do you think that this is very similar to what we see in clinical practice? And what does this mean in terms of applicability of these results in clinical practice? Dr. Harriet Kluger So that's an excellent question. The brain metastasis clinical research field has somewhat been struggling with this issue of inclusion/exclusion criteria. When we started this, we showed pretty clearly that 5 to 10 millimeter lesions, which are below the RECIST criteria for inclusion, are measurable if you use MRIs with slices that are 1 to 2 millimeters. Most institutions in the United States do use these high-resolution MRIs. I don't know how applicable that is on a worldwide scale, but we certainly lowered the threshold for inclusion so that patients who have a smattering of small brain metastases would be eligible. Now, patients with single large brain metastases, the reason that we excluded those from the trial was because we were afraid that if a patient didn't respond to the systemic therapy that we were going to give them, they could really then develop severe neurological symptoms. So, for patient safety, we used 20 millimeters as the upper level for inclusion. Some of the other trials that I mentioned earlier also excluded patients with very large lesions. Now, in practice, one certainly can do Gamma Knife therapy to the large lesions and leave the smaller ones untreated. So I think it actually is very applicable to clinical practice. Dr. Davide Soldato Thank you very much for that insight, because I think that sometimes criteria for clinical trials, they have to be very restrictive. But then we know that in clinical practice, the applicability of these results is probably broader. So, going a little bit further in the results of the study, I just wanted a little bit of comment from you regarding what you saw in terms of intracranial response rate and duration of response among patients who obtained a response from the combination treatment. Dr. Harriet Kluger So we were actually surprised. When we first designed this study, as I said earlier, we weren't trying to beat out ipilimumab and nivolumab. We were really just trying to exclude those patients who wouldn't have otherwise been eligible for ipilimumab and nivolumab because of edema or possibly even previous radiation necrosis. So it was designed to differentiate between a response rate of 34%, and I believe the lower bound was somewhere in the 20s, because that's what we'd seen in the previous pembrolizumab study. What we saw in the first 20 patients that we enrolled was actually a response rate that far exceeded that. And so we enrolled another cohort to verify that result because we were concerned about premature publishing of a result that we might have achieved just by chance. The two cohorts were very similar in terms of the response rates. And certainly this still needs to be verified in a second study with additional institutions. We did include the Moffitt Cancer Center, and the response rate with Moffitt Cancer Center was very similar to the Yale Cancer Center response rate. Now, your other question was about duration of response. So the other thing that we started asking ourselves was whether this high response rate was really because the administration of the anti-VEGF will decrease the gadolinium enhancement and therefore we might actually just be seeing prettier scans but not tumor shrinkage. And the way to differentiate those two is by looking at the duration of the response. Median progression-free survival was 2.2 years. That's pretty long. The upper bound on the 95% confidence interval was not reached. I can't tell you that the duration is as good as the duration would be when you give ipilimumab. Perhaps it is less good. This was a fairly sick population of patients, and it included some who might not have been able to receive ipilimumab and nivolumab. So it provides an alternative. I do believe that we need to do a randomized trial where we compare it to ipilimumab and nivolumab, which is the current standard of care in this patient population. We do need to interpret these results with caution. I also want to point out regarding the progression-free survival that we only gave four doses of anti-VEGF. So one would think that even though anti-VEGF has a long half-life of three or four weeks, two years later, you no longer have anti-VEGF effect, presumably. So it does something when it's administered fairly early on in the course of the treatment. Dr. Davide Soldato So, in terms of clinical applicability, do you see this combination of pembrolizumab and bevacizumab - and of course, as we mentioned, this was a phase 2 trial. The number of patients included was not very high, but still you saw some very promising results when compared with the combination of ipilimumab and nivolumab. So do you see this combination as something that should be given particularly to those patients who might not be able to receive ipilimumab and nivolumab? So, for example, patients who are very symptomatic from the start or require a high dose of steroids, or also to provide a quicker response in terms of patients who have neurological symptoms, or do you think that someday it could be potentially used for all patients? Dr. Harriet Kluger The third part of your question, whether it can be used someday for all patients: I think we need to be very careful when we interpret these results. The study was substantially smaller than the ipilimumab/nivolumab trial that was conducted by Bristol Myers Squibb. Also going to point out that was a different population of patients. Those were all frontline patients. Here we had a mix of patients who'd had previous anti-CTLA-4 and frontline patients. So I don't think that we can replace ipilimumab and nivolumab with these results. But certainly the steroid-sparing aspect of it is something that we really need to take into consideration. A lot of patients have lesions in locations where edema can be dangerous, and some of them have a hard time coming off the steroids. So this is certainly a good approach for those folks. Dr. Davide Soldato And coming back to something that you mentioned in the very introduction, when you said that there were two main problems, which was one, the problem of the edema, and the second one, the problem of the radionecrosis. In your trial, there was a fair percentage of patients who received some type of local treatment before the systemic one. So the combination of pembrolizumab and bevacizumab. And most of the patients received radiosurgery. So I just wanted a brief comment regarding the incidence of radionecrosis in the trial and whether that specific component of the combination with bevacizumab was reduced. And how do you think that this fares in terms of what we see in clinical practice in terms of radionecrosis? Dr. Harriet Kluger I'm not sure that we really reduced the incidence of radiation necrosis. We saw radiation necrosis here. We saw less of it than in the trial of pembrolizumab monotherapy, but these were also different patients, different time. We saw more than we thought that we were going to see. It was 27%, I believe, which is fairly high still. We only gave the four doses of bevacizumab. Maybe to really prevent radiation necrosis, you have to continue to give the bevacizumab. That, too, needs to be tested. The reason that we gave the four doses of bevacizumab was simply because of the cost of the bevacizumab at the time. Dr. Davide Soldato Thank you very much for that comment on radionecrosis. And I really think that potentially this is a strategy, so continuing the bevacizumab, that really makes a lot of sense, especially considering that the tolerability of the regimen was really very, very good, and you didn't see any significant or serious adverse events related to bevacizumab. So just wondering if you could comment a little bit on the toxicities, whether you had anything unexpected. Dr. Harriet Kluger There was one patient who had a microperforation of a diverticulum, which was probably related to the bevacizumab. It was conservatively managed, and the patient did fine and actually remains alive now, many years later. We had one patient who had dehiscence of a previous wound. So there is some. We did not see any substantial hypertension, proteinuria, but we only gave the four doses. So it is possible that if you give it for longer, we would see some side effects. But still, relative to ipilimumab, it's very, very well tolerated. Dr. Davide Soldato Yeah, exactly. I think that the safety profile is really different when we compare the combination of ipilimumab/nivolumab with the pembrolizumab/bevacizumab. And as you said, this was a very small trial and probably we need additional results. But still, these results, in terms of tolerability and safety, I think they are very interesting. So one additional question that I think warrants a little bit of comment on your part is actually related to the presence of patients with BRAF mutation and, in general, to what you think would be the best course of treatment for these patients who present with the upfront brain metastases. So this, it's actually not completely related to the study, but I think that since patients with BRAF mutation were included, I think that this warrants a little bit of discussion on your part. Dr. Harriet Kluger So we really believe that long-term disease control, particularly in brain metastases, doesn't happen when you give BRAF/MEK inhibitors. You sometimes get long-term control if you've got oligometastatic disease in extracranial sites and if they've previously been treated with a lot of immune checkpoint inhibitors, which wasn't the case over here. So a patient who presents early in the course of the disease, regardless of their BRAF status, I do believe that between our studies and all the studies that have been done on immunotherapy earlier in the course of disease, we should withhold BRAF/MEK inhibitors unless they have overwhelming disease and we need immediate disease control, and then we switch them very quickly to immunotherapy. Can I also say something about the toxicity question from the bevacizumab? I have one more comment to make. I think it's important. We were very careful not to include patients who had overt hemorrhage from brain metastases. So melanoma brain metastases relative to other tumor types tend to bleed, and that was an exclusion criteria. We didn't see any bleeding that was attributable to the bevacizumab, but we don't know for sure that, if this is widely used, that that might not be a problem that's observed. So I would advise folks to use extreme caution and perhaps not use it outside of the setting of a clinical trial in patients with overt hemorrhage in the melanoma brain metastases. Dr. Davide Soldato Thank you very much. I think that one aspect that is really interesting in the trial is actually related to the fact that you collected a series of biomarkers, both circulating ones, but also some that were collected actually from the tissue. So just wondering if you could explain a little bit which type of biomarkers you evaluated and whether you saw any significant results that could suggest higher or lower efficacy of the combination. Dr. Harriet Kluger Thank you for that. So yes, the biomarker studies are fairly exploratory, and I want to emphasize that we don't have anything that's remotely useful in clinical practice at this juncture. But we did see an association between vessel density in the tumors and improved response to this regimen. So possibly those lesions that are more vascular are more fed by or driven by VEGF, and that could be the reason that there was improved response. We also saw that when there was less of an increase in circulating angiopoietin-2 levels, patients were more likely to respond. Whether or not that pans out in larger cohorts of patients remains to be determined. Dr. Davide Soldato Still, do you envision validation of these biomarkers in a potentially additional trial that will evaluate, again, the combination? Because I think that the signals were quite interesting, and they really make sense from a biological point of view, considering the mechanism of action of bevacizumab. So I think that, yeah, you're right, they are exploratory. But still, I think that there is very strong biological rationale. So really I wanted to congratulate you on including that specific part and on reporting it. And so the question is, really, do you envision validation of these biomarkers in larger cohorts? Dr. Harriet Kluger I would hope to see that, just as I'd like to see validation of the clinical results as well. The circulating biomarkers are very easy to do. It's a simple ELISA test. And the vessel density on the tumor is essentially CD34 staining and units per area of tumor. Also very simple to do. So I'd love to see that happen. Dr. Davide Soldato Do you think that considering the quality of the MRI that we are using right now, it would be possible to completely bypass even the evaluation on the tissue? Like, are we going in a direction where we can, at a certain point, say the amount of vessels that we see in these metastases is higher versus lower just based on MRI results? Dr. Harriet Kluger You gave me an outstanding idea for a follow-up study. I don't know whether you can measure the intensity of gadolinium as a surrogate, but certainly something worth asking our neuroradiology colleagues. Excellent idea. Thank you. Dr. Davide Soldato You're welcome. So just moving a step further, we spoke a lot about the validation of these results and the combination. And just wanted your idea on what do you think it would be more interesting to do: if designing a clinical trial that really compares pembrolizumab/bevacizumab with ipilimumab and nivolumab or going directly for the triplet. So we know that there has been some type of exploration of triplet combination in metastatic melanoma. So just your clinical impression: What would you do as an investigator? Dr. Harriet Kluger So it's under some discussion, actually. It's very difficult to compare drugs from different companies in an investigator-initiated trial. Perhaps our European colleagues can do that trial for us. In the United States, it's much harder, but it can be done through the cooperative groups, and we are actually having some discussions about that. I don't have the answer for you. It would be lovely to have a trial that compared the three drugs to ipi/nivo and to pembrolizumab/bevacizumab. So a three-arm trial. But remember, these are frontline melanoma patients. There aren't that many of them anymore like there used to be. So accrual will be hard, and we have to be practical. Dr. Davide Soldato Yeah, you're right. And in the discussion of the manuscript, you actually mentioned some other trials that are ongoing, especially one that is investigating the combination of pembro and lenvatinib, another one that is investigating the combination of nivolumab and relatlimab. So just wondering, do you think that the molecule in terms of VEGF inhibition, so bevacizumab versus lenvatinib, can really make a difference or is going to be just a mechanism of action? Of course, we don't have the results from this trial but just wondering if you could give us a general comment or your opinion on the topic. Dr. Harriet Kluger So that's a really great question. The trial of pembrolizumab and lenvatinib was our answer to the fact that bevacizumab is not manufactured by the same company as pembrolizumab, and we're trying to give a practical answer to our next study that might enable us to take this approach further. But it does turn out from our preclinical studies that bevacizumab and VEGF receptor inhibition aren't actually the same thing in terms of the effects on the blood-brain barrier or the perilesional tumor microenvironment in the brain. And these studies were done in mice and in in vitro models. Very different effects. The lenvatinib has stronger effect on the tumors themselves, the tumor cells themselves, than the bevacizumab, which has no effect whatsoever. But the lenvatinib doesn't appear to tighten up that blood-brain barrier. Dr. Davide Soldato Thank you. I think that's very interesting, and I think it's going to be interesting to see also results of these trials to actually improve and give more options to our patients in terms of different mechanism of action, different side effects. Because in the end, one thing that we discussed is that some combination may be useful in some specific clinical situation while others cannot be applicable, like, for example, an all immunotherapy-based combination. Just one final comment, because I think that we focused a lot on the intracranial response and progression-free survival. You briefly mentioned this but just wanted to reinforce the concept. Did you see any differences in terms of intracranial versus extracranial response for those patients who also had extracranial disease with the combination of pembro and bevacizumab? Dr. Harriet Kluger So the responses were almost always concordant. There were a couple of cases that might have had a body response and not an intracranial response and vice-versa, but the vast majority had concordant response or progression. We do believe that it's a biological phenomenon. The type of tumor that tends to go to the brain is going to be the type of tumor that will respond to whatever the regimen is that we're giving. In the previous trial also, we saw concordance of responses in the body and the brain. Dr. Davide Soldato Thank you very much. Just to highlight that really the combination is worth pursuing considering that there was not so much discordant responses, and the results, even in a phase 2 trial, were very, very promising. So thank you again, Dr. Kluger, for joining us today and giving us a little bit of insight into this very interesting trial. Dr. Harriet Kluger Thank you for having me. Dr. Davide Soldato So we appreciate you sharing more on your JCO article titled "Phase 2 Trial of Pembrolizumab in Combination with Bevacizumab for Untreated Melanoma Brain Metastases," which gave us the opportunity to discuss current treatment landscape in metastatic melanoma and future direction in research for melanoma brain metastasis. If you enjoy our show, please leave us a rating and review and be sure to come back for another episode. You can find all ASCO shows at asco.org/podcasts.   The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.

Humans Exhaust Me
Smug AF

Humans Exhaust Me

Play Episode Listen Later Apr 30, 2025 38:00


Paul was off being an influencer last week - he looks so pretty. In fact Paul and Phylecia have swapped roles in life.Subsequently there's stuff to catch up on:The death of Pope FrancisDisney cultureThe Spanish/Portuguese black outFor everyone that questioned the importance of being prepared, Paul in particular is smug AF. We're way ahead of you. Here's the UK government's page - because you know they will say they told you to get ready: https://prepare.campaign.gov.uk/get-prepared-for-emergencies/And for our US listeners: https://www.ready.gov/Support the show at https://humans-exhaust-me.captivate.fm/supportA LikeMind Media production

Totally Rad Christmas!
LOST EPISODE: Don't Open Till Christmas (w/ Ron and Jay)

Totally Rad Christmas!

Play Episode Listen Later Apr 28, 2025 66:53


What's up, dudes? It's a lost episode! It was originally recorded in 2024, but delayed due to lost and inferior audio. Yes, Ron and Jay from the Film Strip podcast are with me to dig into the low budget 1984 Santa slasher "Don't Open Till Christmas!"It's Christmas in London, and Scotland Yard is after a mysterious slayer of Santas. Somebody's killing people dressed like Santa Claus, and when Kate Brioski's father is murdered she heads to the police. Subsequently, Chief Inspector Harris and Detective Sergeant Powell investigate everyone from Kate's boyfriend to the enigmatic Giles. Meanwhile, Santas are burned roasting chestnuts, stabbed in the London Dungeon, and castrated. As the bodies pile up, it's revealed that Giles is not actually a reporter, but the traumatized brother of Harris. As a child, he witnessed the infidelity of his Father Christmas-clad father and the death of his mother. Now hating Christmas, he sought revenge. Spoilers: he eventually dies.Santa perverts? Check. ridiculous medieval weapon kills? Got 'em. Eyes that seem to smile behind a mask? Only from the killer! So grab your knife, leave your Santa suit behind, and defend yourself from this episode on "Don't Open Till Christmas!"Film Strip PodcastFB: @filmstrippodIG: @filmstrippodTwitter: @FilmStripPodGive us a buzz! Send a text, dudes!Check us out on Facebook, Twitter, Instagram, Totally Rad Christmas Mall & Arcade, Teepublic.com, or TotallyRadChristmas.com! Later, dudes!

Journal of Clinical Oncology (JCO) Podcast
JCO Article Insights: ESPAC4 Long-Term Follow-Up in Pancreatic Cancer

Journal of Clinical Oncology (JCO) Podcast

Play Episode Listen Later Apr 28, 2025 6:47


In this JCO Article Insights episode, host Jospeh Mathew summaries Pancreatic Adenocarcinoma: Long-Term Outcomes of Adjuvant Therapy in the ESPAC4 Phase III Trial, by Palmer, et al published December 5, 2024. Transcript Joseph Matthew: Hello and welcome to the Journal of Clinical Oncology Article Insights. I'm your host, Joseph Matthew, and today we will be discussing the article "Long-Term Survival in Resected Pancreatic Ductal Adenocarcinoma with Adjuvant Gemcitabine plus Capecitabine Compared to Modified FOLFIRINOX from the ESPAC-4 and the PRODIGE 24 Trials" by Dr. Palmer et al. To summarize the relevant evidence, the ESPAC-4 was a European phase 3 multicenter randomized clinical trial published in 2017 comparing adjuvant gemcitabine and capecitabine (GemCap) with gemcitabine monotherapy following macroscopic margin-negative resections for operable pancreatic ductal adenocarcinoma (PDAC). The trial had included non-metastatic patients aged 18 years or older, World Health Organization (WHO) performance scores of 2 or less, creatinine clearance of at least 50 mL/min, and a life expectancy of over three months who had not received any prior anticancer treatment. Patients who had undergone R2 resections were selectively excluded. Eligible participants were randomized 1:1 within 12 weeks of pancreatectomy to one of the two treatment arms, with chemotherapy initiated within two weeks from the date of randomization. The regimens involved six cycles, each lasting four weeks, for an overall duration of 24 weeks. In the monotherapy arm, gemcitabine dosed at 1 g/m² was given as an intravenous infusion once a week for three weeks, followed by one week off. In the GemCap arm, capecitabine dosed at 1660 mg/m² was added to gemcitabine, given daily for three weeks, followed by one week off. Patients were followed up every three months, with the primary endpoint being overall survival (OS). The study showed that at a median follow-up of 43.2 months, GemCap was associated with a significantly longer OS than gemcitabine alone. Subsequently, in 2018, the Phase 3 randomized PRODIGE 24 trial was conducted in centers across France and Canada, comparing adjuvant modified FOLFIRINOX (mFOLFIRINOX) with gemcitabine in a similar subset of patients with resected PDAC and reported longer OS with the mFOLFIRINOX regimen. This study, however, had more restrictive eligibility criteria when compared to ESPAC-4, including patients aged under 80 years, WHO performance status of 0 or 1, with no significant cardiovascular disease, and a postoperative serum CA 19-9 of less than 180 U/mL. There was hence a subset of ESPAC-4 patients who did not meet the eligibility criteria for mFOLFIRINOX as set by the PRODIGE 24. The present study was conducted to estimate the overall 5-year survival rates for patients of ESPAC-4 receiving GemCap and gemcitabine, further stratifying survival in either arm according to the status of the surgical margins (R status) and the resected nodes (N status), and also to investigate whether GemCap retained a survival benefit over gemcitabine in PRODIGE 24-ineligible patients. A total of 732 patients, evenly distributed between both arms, were followed up for a median period of 104 months. Adjuvant GemCap was found to retain its survival advantage over gemcitabine, with a significantly longer median OS of 31.6 months when compared to 28.4 months with gemcitabine alone. Further subgroup analysis was performed with reference to the resection margins and the nodal status. As a reminder, in the ESPAC-4 trial, 60% of patients were found to have microscopically positive margins (an R1 resection), and 80% were node-positive. The difference in survival was greater in patients undergoing microscopic margin-negative resections (R0) who experienced a median OS of 49.9 months with GemCap when compared to 32.2 months with gemcitabine. Node-negative patients also had a significantly greater 5-year OS rate with GemCap of 59% versus 53% with gemcitabine monotherapy. However, it is important to note that no significant difference in survival outcomes was observed in margin-positive (R1) or node-positive patients in the two arms. The investigators also evaluated GemCap in the subgroup of 193 patients (comprising 26.4% of the ESPAC-4 cohort) who were not considered to have met the eligibility criteria for PRODIGE 24. The survival benefit of combination therapy was retained in this group, with patients receiving GemCap experiencing a median survival of 25.9 months compared to 20.7 months with adjuvant gemcitabine. Although cross-trial comparisons have limited validity, good agreement was noted in adverse grade 3 or greater toxicity associated with the control gemcitabine arms of ESPAC-4 and PRODIGE 24, serving as the basis for a qualitative comparison of toxicities between mFOLFIRINOX and GemCap. Neutropenia was more prevalent in the GemCap arm, affecting 40.8% of patients compared to 28.4% with mFOLFIRINOX. However, granulocyte colony-stimulating factor (G-CSF) was administered to 62.2% of patients in PRODIGE 24. Palmar-plantar erythrodysesthesia (PPE) was also more prevalent with GemCap. Patients on mFOLFIRINOX were more likely to observe grade 3 or greater fatigue, diarrhea, nausea and vomiting, sensory peripheral neuropathy, and paresthesias. The investigators concluded that GemCap was the standard adjuvant treatment for patients with PDAC undergoing an upfront resection who were not feasible for mFOLFIRINOX. Further exploratory analysis revealed that patients under the age of 70 who had undergone a microscopic margin-negative (R0) resection for node-negative PDAC were likely to derive an OS benefit from the addition of capecitabine to gemcitabine in the adjuvant setting. In contrast, mFOLFIRINOX would be more effective than gemcitabine in patients with positive margins (R1) or involved nodes, as per the PRODIGE 24 trial. Thank you for listening to JCO Article Insights. Please come back for more interviews and article summaries, and be sure to leave us a rating and review so others can find our show. For more podcasts and episodes from ASCO, please visit ASCO.org/podcasts. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions.   Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.

Joy Stephen's Canada Immigration Podcast
Canada Immigration LMIA-Exempt Work Permit figures for C11, (C11 Self-employed or potential provincial nominee as an entrepreneur) in 2021, for Total visas issued by IRCC.

Joy Stephen's Canada Immigration Podcast

Play Episode Listen Later Apr 28, 2025 3:27


 Canada Immigration LMIA-Exempt Work Permit figures for C11,  (C11 Self-employed or potential provincial nominee as an entrepreneur) in  2021, for Total visas issued by IRCC. Good day ladies and gentlemen, this is IRC news, and I am Joy Stephen, an authorized Canadian Immigration protal Visas actitioner bringing out this Canada Work Permit application data specific to LMIA work permits or employer driven work permits or LMIA exempt work permits for multiple years based on your country of Citizenship. I am coming to you from the Polinsys studios in Cambridge, Ontario  In 2021, a total of  120 LMIA-Exempt Work Permits were issued by IRCC, under C11, (C11 Self-employed or potential provincial nominee as an entrepreneur).  If you have an interest in gaining assistance with Work Permits based on your country of Citizenship, or should you require guidance post-selection, we extend a warm invitation to connect with us via https://myar.me/c. We strongly recommend attending our complimentary Zoom resource meetings conducted every Thursday. We kindly request you to carefully review the available resources. Subsequently, should any queries arise, our team of Canadian Authorized Representatives is readily available to address your concerns during the weekly AR's Q&A session held on Fridays. You can find the details for both these meetings at https://myar.me/zoom. Our dedicated team is committed to providing you with professional assistance in navigating the immigration process. Additionally, IRCNews offers valuable insights on selecting a qualified representative to advocate on your behalf with the Canadian Federal or Provincial governments, accessible at https://ircnews.ca/consultant 

Joy Stephen's Canada Immigration Podcast
Canada Immigration LMIA-Exempt Work Permit figures for C11, (C11 Self-employed or potential provincial nominee as an entrepreneur) in 2023, for visas issued without a Provincial attachment.

Joy Stephen's Canada Immigration Podcast

Play Episode Listen Later Apr 28, 2025 3:29


Canada Immigration LMIA-Exempt Work Permit figures for C11, (C11 Self-employed or potential provincial nominee as an entrepreneur) in 2023, for visas issued without a Provincial attachment.Good day ladies and gentlemen, this is IRC news, and I am Joy Stephen, an authorized Canadian Immigration protal Visas actitioner bringing out this Canada Work Permit application data specific to LMIA work permits or employer driven work permits or LMIA exempt work permits for multiple years based on your country of Citizenship. I am coming to you from the Polinsys studios in Cambridge, Ontario  In 2023, a total of 5 LMIA-Exempt Work Permits were approved without a provincial attachment, under C11, (C11 Self-employed or potential provincial nominee as an entrepreneur).   If you have an interest in gaining assistance with Work Permits based on your country of Citizenship, or should you require guidance post-selection, we extend a warm invitation to connect with us via https://myar.me/c. We strongly recommend attending our complimentary Zoom resource meetings conducted every Thursday. We kindly request you to carefully review the available resources. Subsequently, should any queries arise, our team of Canadian Authorized Representatives is readily available to address your concerns during the weekly AR's Q&A session held on Fridays. You can find the details for both these meetings at https://myar.me/zoom. Our dedicated team is committed to providing you with professional assistance in navigating the immigration process. Additionally, IRCNews offers valuable insights on selecting a qualified representative to advocate on your behalf with the Canadian Federal or Provincial governments, accessible at https://ircnews.ca/consultant

Joy Stephen's Canada Immigration Podcast
Canada Immigration LMIA-Exempt Work Permit figures for C11, (C11 Self-employed or potential provincial nominee as an entrepreneur) in 2023 for the province/territory of Alberta.

Joy Stephen's Canada Immigration Podcast

Play Episode Listen Later Apr 28, 2025 3:24


Canada Immigration LMIA-Exempt Work Permit figures for C11, (C11 Self-employed or potential provincial nominee as an entrepreneur) in 2023 for the province/territory of Alberta.  Good day ladies and gentlemen, this is IRC news, and I am Joy Stephen, an authorized Canadian Immigration practitioner bringing out this Canada Work Permit application data specific to LMIA work permits or employer driven work permits or LMIA exempt work permits for multiple years based on your country of Citizenship. I am coming to you from the Polinsys studios in Cambridge, Ontario   The Province or Territory of Alberta accepted 35 LMIA-Exempt Work Permits in 2023, under C11, (C11 Self-employed or potential provincial nominee as an entrepreneur). Stay informed about past events in Alberta by visiting this link: https://myar.me/tag/ab  If you are interested in gaining comprehensive insights into the Federal Canadian Experience Class or other Canadian Federal or Provincial Immigration programs, or if you need guidance post-selection, we cordially invite you to connect with us via https://myar.me/c.  We highly recommend attending our complimentary Zoom resource meetings held every Thursday. We kindly request you to thoroughly review the available resources. Subsequently, if you have any questions, our team of Canadian Authorized Representatives is readily available to address your concerns during the weekly AR's Q&A session on Fridays. You can find details for both these meetings at https://myar.me/zoom.  Our dedicated team is committed to providing professional assistance throughout your immigration journey. Furthermore, IRCNews offers valuable insights on selecting a qualified representative to advocate on your behalf with the Canadian Federal or Provincial governments, accessible at https://ircnews.ca/consultant.           

Joy Stephen's Canada Immigration Podcast
Canada Immigration LMIA-Exempt Work Permit figures for C11, (C11 Self-employed or potential provincial nominee as an entrepreneur) in 2023 for the province/territory of British Columbia.

Joy Stephen's Canada Immigration Podcast

Play Episode Listen Later Apr 28, 2025 3:27


Canada Immigration LMIA-Exempt Work Permit figures for C11, (C11 Self-employed or potential provincial nominee as an entrepreneur) in 2023 for the province/territory of British Columbia.  Good day ladies and gentlemen, this is IRC news, and I am Joy Stephen, an authorized Canadian Immigration practitioner bringing out this Canada Work Permit application data specific to LMIA work permits or employer driven work permits or LMIA exempt work permits for multiple years based on your country of Citizenship. I am coming to you from the Polinsys studios in Cambridge, Ontario  The Province or Territory of British Columbia accepted 135 LMIA-Exempt Work Permits in 2023, under C11, (C11 Self-employed or potential provincial nominee as an entrepreneur).  To delve into the history of news in Manitoba, follow this link: https://myar.me/tag/bc  If you have an interest in gaining comprehensive insights into the Canadian Federal Spouses and Partners sponsorship program or other Canadian Federal or Provincial Immigration programs, or should you require guidance post-selection, we extend a warm invitation to connect with us via https://myar.me/c.  We strongly recommend attending our complimentary Zoom resource meetings conducted every Thursday. We kindly request you to carefully review the available resources. Subsequently, should any queries arise, our team of Canadian Authorized Representatives is readily available to address your concerns during the weekly AR's Q&A session held on Fridays. You can find the details for both these meetings at https://myar.me/zoom.  Our dedicated team is committed to providing you with professional assistance in navigating the immigration process. Additionally, IRCNews offers valuable insights on selecting a qualified representative to advocate on your behalf with the Canadian Federal or Provincial governments, accessible at https://ircnews.ca/consultant.        

Joy Stephen's Canada Immigration Podcast
Canada Immigration LMIA-Exempt Work Permit figures for C11, (C11 Self-employed or potential provincial nominee as an entrepreneur) in 2023 for the province/territory of Manitoba.

Joy Stephen's Canada Immigration Podcast

Play Episode Listen Later Apr 28, 2025 3:25


Canada Immigration LMIA-Exempt Work Permit figures for C11, (C11 Self-employed or potential provincial nominee as an entrepreneur) in 2023 for the province/territory of Manitoba.  Good day ladies and gentlemen, this is IRC news, and I am Joy Stephen, an authorized Canadian Immigration practitioner bringing out this Canada Work Permit application data specific to LMIA work permits or employer driven work permits or LMIA exempt work permits for multiple years based on your country of Citizenship. I am coming to you from the Polinsys studios in Cambridge, Ontario  The Province or Territory of Manitoba accepted 40 LMIA-Exempt Work Permits in 2023, under C11, (C11 Self-employed or potential provincial nominee as an entrepreneur). To delve into the history of news in Manitoba, follow this link: https://myar.me/tag/mb  If you have an interest in gaining comprehensive insights into the Canadian Federal Spouses and Partners sponsorship program or other Canadian Federal or Provincial Immigration programs, or should you require guidance post-selection, we extend a warm invitation to connect with us via https://myar.me/c.  We strongly recommend attending our complimentary Zoom resource meetings conducted every Thursday. We kindly request you to carefully review the available resources. Subsequently, should any queries arise, our team of Canadian Authorized Representatives is readily available to address your concerns during the weekly AR's Q&A session held on Fridays. You can find the details for both these meetings at https://myar.me/zoom.  Our dedicated team is committed to providing you with professional assistance in navigating the immigration process. Additionally, IRCNews offers valuable insights on selecting a qualified representative to advocate on your behalf with the Canadian Federal or Provincial governments, accessible at https://ircnews.ca/consultant.          

Joy Stephen's Canada Immigration Podcast
Canada Immigration LMIA-Exempt Work Permit figures for C11, (C11 Self-employed or potential provincial nominee as an entrepreneur) in 2022, for Total visas issued by IRCC.

Joy Stephen's Canada Immigration Podcast

Play Episode Listen Later Apr 28, 2025 3:27


Canada Immigration LMIA-Exempt Work Permit figures for C11, (C11 Self-employed or potential provincial nominee as an entrepreneur) in 2022, for Total visas issued by IRCC.Good day ladies and gentlemen, this is IRC news, and I am Joy Stephen, an authorized Canadian Immigration practitioner bringing out this Canada Work Permit application data specific to LMIA work permits or employer driven work permits or LMIA exempt work permits for multiple years based on your country of Citizenship. I am coming to you from the Polinsys studios in Cambridge, Ontario  In 2022, a total of  490 LMIA-Exempt Work Permits were issued by IRCC, under C11, (C11 Self-employed or potential provincial nominee as an entrepreneur).  If you have an interest in gaining assistance with Work Permits based on your country of Citizenship, or should you require guidance post-selection, we extend a warm invitation to connect with us via https://myar.me/c. We strongly recommend attending our complimentary Zoom resource meetings conducted every Thursday. We kindly request you to carefully review the available resources. Subsequently, should any queries arise, our team of Canadian Authorized Representatives is readily available to address your concerns during the weekly AR's Q&A session held on Fridays. You can find the details for both these meetings at https://myar.me/zoom. Our dedicated team is committed to providing you with professional assistance in navigating the immigration process. Additionally, IRCNews offers valuable insights on selecting a qualified representative to advocate on your behalf with the Canadian Federal or Provincial governments, accessible at https://ircnews.ca/consultant

Joy Stephen's Canada Immigration Podcast
Canada Immigration LMIA-Exempt Work Permit figures for C11, (C11 Self-employed or potential provincial nominee as an entrepreneur) in 2023, for Total visas issued by IRCC.

Joy Stephen's Canada Immigration Podcast

Play Episode Listen Later Apr 28, 2025 3:27


Canada Immigration LMIA-Exempt Work Permit figures for C11,  (C11 Self-employed or potential provincial nominee as an entrepreneur) in  2023, for Total visas issued by IRCC.Good day ladies and gentlemen, this is IRC news, and I am Joy Stephen, an authorized Canadian Immigration practitioner bringing out this Canada Work Permit application data specific to LMIA work permits or employer driven work permits or LMIA exempt work permits for multiple years based on your country of Citizenship. I am coming to you from the Polinsys studios in Cambridge, Ontario  In 2023, a total of  630 LMIA-Exempt Work Permits were issued by IRCC, under C11, (C11 Self-employed or potential provincial nominee as an entrepreneur).  If you have an interest in gaining assistance with Work Permits based on your country of Citizenship, or should you require guidance post-selection, we extend a warm invitation to connect with us via https://myar.me/c. We strongly recommend attending our complimentary Zoom resource meetings conducted every Thursday. We kindly request you to carefully review the available resources. Subsequently, should any queries arise, our team of Canadian Authorized Representatives is readily available to address your concerns during the weekly AR's Q&A session held on Fridays. You can find the details for both these meetings at https://myar.me/zoom. Our dedicated team is committed to providing you with professional assistance in navigating the immigration process. Additionally, IRCNews offers valuable insights on selecting a qualified representative to advocate on your behalf with the Canadian Federal or Provincial governments, accessible at https://ircnews.ca/consultant

Joy Stephen's Canada Immigration Podcast
Canada Immigration LMIA-Exempt Work Permit figures for C11, (C11 Self-employed or potential provincial nominee as an entrepreneur) in 2022, for visas issued without a Provincial attachment.

Joy Stephen's Canada Immigration Podcast

Play Episode Listen Later Apr 28, 2025 3:30


Canada Immigration LMIA-Exempt Work Permit figures for C11, (C11 Self-employed or potential provincial nominee as an entrepreneur) in 2022, for visas issued without a Provincial attachment.Good day ladies and gentlemen, this is IRC news, and I am Joy Stephen, an authorized Canadian Immigration protal Visas actitioner bringing out this Canada Work Permit application data specific to LMIA work permits or employer driven work permits or LMIA exempt work permits for multiple years based on your country of Citizenship. I am coming to you from the Polinsys studios in Cambridge, Ontario In 2022, a total of 10 LMIA-Exempt Work Permits were approved without a provincial attachment, under C11, (C11 Self-employed or potential provincial nominee as an entrepreneur).  If you have an interest in gaining assistance with Work Permits based on your country of Citizenship, or should you require guidance post-selection, we extend a warm invitation to connect with us via https://myar.me/c. We strongly recommend attending our complimentary Zoom resource meetings conducted every Thursday. We kindly request you to carefully review the available resources. Subsequently, should any queries arise, our team of Canadian Authorized Representatives is readily available to address your concerns during the weekly AR's Q&A session held on Fridays. You can find the details for both these meetings at https://myar.me/zoom. Our dedicated team is committed to providing you with professional assistance in navigating the immigration process. Additionally, IRCNews offers valuable insights on selecting a qualified representative to advocate on your behalf with the Canadian Federal or Provincial governments, accessible at https://ircnews.ca/consultant

Joy Stephen's Canada Immigration Podcast
Canada Immigration LMIA-Exempt Work Permit figures for C11, (C11 Self-employed or potential provincial nominee as an entrepreneur) in 2021 for the province/territory of Quebec.

Joy Stephen's Canada Immigration Podcast

Play Episode Listen Later Apr 28, 2025 3:25


Canada Immigration LMIA-Exempt Work Permit figures for C11, (C11 Self-employed or potential provincial nominee as an entrepreneur) in 2021 for the province/territory of Quebec. Good day ladies and gentlemen, this is IRC news, and I am Joy Stephen, an authorized Canadian Immigration practitioner bringing out this Canada Work Permit application data specific to LMIA work permits or employer driven work permits or LMIA exempt work permits for multiple years based on your country of Citizenship. I am coming to you from the Polinsys studios in Cambridge, Ontario  The Province or Territory of Quebec accepted 10 LMIA-Exempt Work Permits in 2021, under C11, (C11 Self-employed or potential provincial nominee as an entrepreneur).Access archived news articles from Quebec via this link: https://myar.me/tag/qc  If you are interested in gaining comprehensive insights into the Federal Startup Business Program or other Canadian Federal or Provincial Immigration programs, or if you need guidance post-selection, we cordially invite you to connect with us via https://myar.me/c.  We highly recommend attending our complimentary Zoom resource meetings held every Thursday. We kindly request you to thoroughly review the available resources. Subsequently, if you have any questions, our team of Canadian Authorized Representatives is readily available to address your concerns during the weekly AR's Q&A session on Fridays. You can find details for both these meetings at https://myar.me/zoom.  Our dedicated team is committed to providing professional assistance throughout your immigration journey. Furthermore, IRCNews offers valuable insights on selecting a qualified representative to advocate on your behalf with the Canadian Federal or Provincial governments, accessible at https://ircnews.ca/consultant.  

Joy Stephen's Canada Immigration Podcast
Canada Immigration LMIA-Exempt Work Permit figures for C11, (C11 Self-employed or potential provincial nominee as an entrepreneur) in 2021 for the province/territory of Manitoba.

Joy Stephen's Canada Immigration Podcast

Play Episode Listen Later Apr 28, 2025 3:23


Canada Immigration LMIA-Exempt Work Permit figures for C11, (C11 Self-employed or potential provincial nominee as an entrepreneur) in 2021 for the province/territory of Manitoba. Good day ladies and gentlemen, this is IRC news, and I am Joy Stephen, an authorized Canadian Immigration practitioner bringing out this Canada Work Permit application data specific to LMIA work permits or employer driven work permits or LMIA exempt work permits for multiple years based on your country of Citizenship. I am coming to you from the Polinsys studios in Cambridge, Ontario  The Province or Territory of Manitoba accepted 5 LMIA-Exempt Work Permits in 2021, under C11, (C11 Self-employed or potential provincial nominee as an entrepreneur).To delve into the history of news in Manitoba, follow this link: https://myar.me/tag/mb  If you have an interest in gaining comprehensive insights into the Canadian Federal Spouses and Partners sponsorship program or other Canadian Federal or Provincial Immigration programs, or should you require guidance post-selection, we extend a warm invitation to connect with us via https://myar.me/c.  We strongly recommend attending our complimentary Zoom resource meetings conducted every Thursday. We kindly request you to carefully review the available resources. Subsequently, should any queries arise, our team of Canadian Authorized Representatives is readily available to address your concerns during the weekly AR's Q&A session held on Fridays. You can find the details for both these meetings at https://myar.me/zoom.  Our dedicated team is committed to providing you with professional assistance in navigating the immigration process. Additionally, IRCNews offers valuable insights on selecting a qualified representative to advocate on your behalf with the Canadian Federal or Provincial governments, accessible at https://ircnews.ca/consultant.  

Joy Stephen's Canada Immigration Podcast
Canada Immigration LMIA-Exempt Work Permit figures for C11, (C11 Self-employed or potential provincial nominee as an entrepreneur) in 2023 for the province/territory of Quebec.

Joy Stephen's Canada Immigration Podcast

Play Episode Listen Later Apr 28, 2025 3:25


Canada Immigration LMIA-Exempt Work Permit figures for C11, (C11 Self-employed or potential provincial nominee as an entrepreneur) in 2023 for the province/territory of Quebec.  Good day ladies and gentlemen, this is IRC news, and I am Joy Stephen, an authorized Canadian Immigration practitioner bringing out this Canada Work Permit application data specific to LMIA work permits or employer driven work permits or LMIA exempt work permits for multiple years based on your country of Citizenship. I am coming to you from the Polinsys studios in Cambridge, Ontario The Province or Territory of Quebec accepted 25 LMIA-Exempt Work Permits in 2023, under C11, (C11 Self-employed or potential provincial nominee as an entrepreneur).  Access archived news articles from Quebec via this link: https://myar.me/tag/qc  If you are interested in gaining comprehensive insights into the Federal Startup Business Program or other Canadian Federal or Provincial Immigration programs, or if you need guidance post-selection, we cordially invite you to connect with us via https://myar.me/c.  We highly recommend attending our complimentary Zoom resource meetings held every Thursday. We kindly request you to thoroughly review the available resources. Subsequently, if you have any questions, our team of Canadian Authorized Representatives is readily available to address your concerns during the weekly AR's Q&A session on Fridays. You can find details for both these meetings at https://myar.me/zoom.  Our dedicated team is committed to providing professional assistance throughout your immigration journey. Furthermore, IRCNews offers valuable insights on selecting a qualified representative to advocate on your behalf with the Canadian Federal or Provincial governments, accessible at https://ircnews.ca/consultant.       

Joy Stephen's Canada Immigration Podcast
Canada Immigration LMIA-Exempt Work Permit figures for C11, (C11 Self-employed or potential provincial nominee as an entrepreneur) in 2022 for the province/territory of Alberta.

Joy Stephen's Canada Immigration Podcast

Play Episode Listen Later Apr 28, 2025 3:24


Canada Immigration LMIA-Exempt Work Permit figures for C11, (C11 Self-employed or potential provincial nominee as an entrepreneur) in 2022 for the province/territory of Alberta.   Good day ladies and gentlemen, this is IRC news, and I am Joy Stephen, an authorized Canadian Immigration practitioner bringing out this Canada Work Permit application data specific to LMIA work permits or employer driven work permits or LMIA exempt work permits for multiple years based on your country of Citizenship. I am coming to you from the Polinsys studios in Cambridge, Ontario  The Province or Territory of Alberta accepted 15 LMIA-Exempt Work Permits in 2022, under C11, (C11 Self-employed or potential provincial nominee as an entrepreneur). Stay informed about past events in Alberta by visiting this link: https://myar.me/tag/ab  If you are interested in gaining comprehensive insights into the Federal Canadian Experience Class or other Canadian Federal or Provincial Immigration programs, or if you need guidance post-selection, we cordially invite you to connect with us via https://myar.me/c.  We highly recommend attending our complimentary Zoom resource meetings held every Thursday. We kindly request you to thoroughly review the available resources. Subsequently, if you have any questions, our team of Canadian Authorized Representatives is readily available to address your concerns during the weekly AR's Q&A session on Fridays. You can find details for both these meetings at https://myar.me/zoom.  Our dedicated team is committed to providing professional assistance throughout your immigration journey. Furthermore, IRCNews offers valuable insights on selecting a qualified representative to advocate on your behalf with the Canadian Federal or Provincial governments, accessible at https://ircnews.ca/consultant.   

Joy Stephen's Canada Immigration Podcast
Canada Immigration LMIA-Exempt Work Permit figures for C11, (C11 Self-employed or potential provincial nominee as an entrepreneur) in 2022 for the province/territory of British Columbia.

Joy Stephen's Canada Immigration Podcast

Play Episode Listen Later Apr 28, 2025 3:25


Canada Immigration LMIA-Exempt Work Permit figures for C11, (C11 Self-employed or potential provincial nominee as an entrepreneur) in 2022 for the province/territory of British Columbia.   Good day ladies and gentlemen, this is IRC news, and I am Joy Stephen, an authorized Canadian Immigration practitioner bringing out this Canada Work Permit application data specific to LMIA work permits or employer driven work permits or LMIA exempt work permits for multiple years based on your country of Citizenship. I am coming to you from the Polinsys studios in Cambridge, Ontario  The Province or Territory of British Columbia accepted 100 LMIA-Exempt Work Permits in 2022, under C11, (C11 Self-employed or potential provincial nominee as an entrepreneur).  To delve into the history of news in Manitoba, follow this link: https://myar.me/tag/bc  If you have an interest in gaining comprehensive insights into the Canadian Federal Spouses and Partners sponsorship program or other Canadian Federal or Provincial Immigration programs, or should you require guidance post-selection, we extend a warm invitation to connect with us via https://myar.me/c.  We strongly recommend attending our complimentary Zoom resource meetings conducted every Thursday. We kindly request you to carefully review the available resources. Subsequently, should any queries arise, our team of Canadian Authorized Representatives is readily available to address your concerns during the weekly AR's Q&A session held on Fridays. You can find the details for both these meetings at https://myar.me/zoom.  Our dedicated team is committed to providing you with professional assistance in navigating the immigration process. Additionally, IRCNews offers valuable insights on selecting a qualified representative to advocate on your behalf with the Canadian Federal or Provincial governments, accessible at https://ircnews.ca/consultant.  

Joy Stephen's Canada Immigration Podcast
Canada Immigration LMIA-Exempt Work Permit figures for C11, (C11 Self-employed or potential provincial nominee as an entrepreneur) in 2022 for the province/territory of Manitoba.

Joy Stephen's Canada Immigration Podcast

Play Episode Listen Later Apr 28, 2025 3:24


Canada Immigration LMIA-Exempt Work Permit figures for C11, (C11 Self-employed or potential provincial nominee as an entrepreneur) in 2022 for the province/territory of Manitoba.   Good day ladies and gentlemen, this is IRC news, and I am Joy Stephen, an authorized Canadian Immigration practitioner bringing out this Canada Work Permit application data specific to LMIA work permits or employer driven work permits or LMIA exempt work permits for multiple years based on your country of Citizenship. I am coming to you from the Polinsys studios in Cambridge, Ontario  The Province or Territory of Manitoba accepted 30 LMIA-Exempt Work Permits in 2022, under C11, (C11 Self-employed or potential provincial nominee as an entrepreneur).  To delve into the history of news in Manitoba, follow this link: https://myar.me/tag/mb  If you have an interest in gaining comprehensive insights into the Canadian Federal Spouses and Partners sponsorship program or other Canadian Federal or Provincial Immigration programs, or should you require guidance post-selection, we extend a warm invitation to connect with us via https://myar.me/c.  We strongly recommend attending our complimentary Zoom resource meetings conducted every Thursday. We kindly request you to carefully review the available resources. Subsequently, should any queries arise, our team of Canadian Authorized Representatives is readily available to address your concerns during the weekly AR's Q&A session held on Fridays. You can find the details for both these meetings at https://myar.me/zoom.  Our dedicated team is committed to providing you with professional assistance in navigating the immigration process. Additionally, IRCNews offers valuable insights on selecting a qualified representative to advocate on your behalf with the Canadian Federal or Provincial governments, accessible at https://ircnews.ca/consultant.    

Joy Stephen's Canada Immigration Podcast
Canada Immigration LMIA-Exempt Work Permit figures for C11, (C11 Self-employed or potential provincial nominee as an entrepreneur) in 2022 for the province/territory of Quebec.

Joy Stephen's Canada Immigration Podcast

Play Episode Listen Later Apr 28, 2025 3:24


Canada Immigration LMIA-Exempt Work Permit figures for C11, (C11 Self-employed or potential provincial nominee as an entrepreneur) in 2022 for the province/territory of Quebec.   Good day ladies and gentlemen, this is IRC news, and I am Joy Stephen, an authorized Canadian Immigration practitioner bringing out this Canada Work Permit application data specific to LMIA work permits or employer driven work permits or LMIA exempt work permits for multiple years based on your country of Citizenship. I am coming to you from the Polinsys studios in Cambridge, Ontario  The Province or Territory of Quebec accepted 40 LMIA-Exempt Work Permits in 2022, under C11, (C11 Self-employed or potential provincial nominee as an entrepreneur). Access archived news articles from Quebec via this link: https://myar.me/tag/qc  If you are interested in gaining comprehensive insights into the Federal Startup Business Program or other Canadian Federal or Provincial Immigration programs, or if you need guidance post-selection, we cordially invite you to connect with us via https://myar.me/c.  We highly recommend attending our complimentary Zoom resource meetings held every Thursday. We kindly request you to thoroughly review the available resources. Subsequently, if you have any questions, our team of Canadian Authorized Representatives is readily available to address your concerns during the weekly AR's Q&A session on Fridays. You can find details for both these meetings at https://myar.me/zoom.  Our dedicated team is committed to providing professional assistance throughout your immigration journey. Furthermore, IRCNews offers valuable insights on selecting a qualified representative to advocate on your behalf with the Canadian Federal or Provincial governments, accessible at https://ircnews.ca/consultant. 

Joy Stephen's Canada Immigration Podcast
Canada Immigration LMIA-Exempt Work Permit figures for C11, (C11 Self-employed or potential provincial nominee as an entrepreneur) in 2021 for the province/territory of British Columbia.

Joy Stephen's Canada Immigration Podcast

Play Episode Listen Later Apr 28, 2025 3:25


 Canada Immigration LMIA-Exempt Work Permit figures for C11, (C11 Self-employed or potential provincial nominee as an entrepreneur) in 2021 for the province/territory of British Columbia.  Good day ladies and gentlemen, this is IRC news, and I am Joy Stephen, an authorized Canadian Immigration practitioner bringing out this Canada Work Permit application data specific to LMIA work permits or employer driven work permits or LMIA exempt work permits for multiple years based on your country of Citizenship. I am coming to you from the Polinsys studios in Cambridge, Ontario  The Province or Territory of British Columbia accepted 30 LMIA-Exempt Work Permits in 2021, under C11, (C11 Self-employed or potential provincial nominee as an entrepreneur). To delve into the history of news in Manitoba, follow this link: https://myar.me/tag/bc  If you have an interest in gaining comprehensive insights into the Canadian Federal Spouses and Partners sponsorship program or other Canadian Federal or Provincial Immigration programs, or should you require guidance post-selection, we extend a warm invitation to connect with us via https://myar.me/c.  We strongly recommend attending our complimentary Zoom resource meetings conducted every Thursday. We kindly request you to carefully review the available resources. Subsequently, should any queries arise, our team of Canadian Authorized Representatives is readily available to address your concerns during the weekly AR's Q&A session held on Fridays. You can find the details for both these meetings at https://myar.me/zoom.  Our dedicated team is committed to providing you with professional assistance in navigating the immigration process. Additionally, IRCNews offers valuable insights on selecting a qualified representative to advocate on your behalf with the Canadian Federal or Provincial governments, accessible at https://ircnews.ca/consultant.  

The Alien UFO Podcast
From Naval Intelligence to Personal ET Encounters

The Alien UFO Podcast

Play Episode Listen Later Apr 24, 2025 60:00


In 2015, Matthew Roberts was a US Naval service member stationed onboard the USS Theodore Roosevelt. The events that transpired during their 2015 workup cycle brought us the first-ever declassified footage of unidentified aerial phenomenon (UAP)and the New York Times article titled: “Glowing Auras and ‘Black Money': The Pentagon's Mysterious U.F.O. Program.” Subsequently, he transferred to the Office of Naval Intelligence in Washington D.C. where he began to have frequent, and often intense, personal experiences with the phenomenon.He discovered through a long, painful, and terrifying journey that the truth of the phenomenon has deep and profound implications for the future of the human race. It may seem like a bold statement but the ultimate universal truth that underlies the phenomenon is captured in the simple yet eloquent words of Mark Twain, “The two most important days in your life are the day you are born, and the day you find out why.”https://www.amazon.com/dp/B08P9MSQYD https://www.pastliveshypnosis.co.uk/https://www.patreon.com/alienufopodcastMy book 'Verified Near Death Exeriences' https://www.amazon.com/dp/B0DXKRGDFP

Talking Out Your Glass podcast
Stephanie Trenchard: Casting Womens' Narratives in Glass

Talking Out Your Glass podcast

Play Episode Listen Later Apr 18, 2025 73:26


Stephanie Trenchard's multi-disciplinary creative process includes painting and poetry along with cast glass. With a focus on biographical stories of how women artists have navigated careers and partnerships, motherhood and making a living while still focusing on their creative practice, the work also discusses the price the art has to pay in this grand juggling act. The artist prioritizes the actual experience of the work, making and seeing it, over the classification of genre or ownership of an idea.  Says Trenchard: “I create my own visual vocabulary in storytelling. Using these totems, I tell stories about the artistic experience and the ensuing personal relationships usually based on true stories of artists from history. The subject of these narratives is often revealed in the title of the piece, but it is not necessary that the viewer be familiar with the subject in order to understand the concept because the metaphors are universal to the human condition.” Her work also involves using art as a way to communicate local activism as seen in her project About Sturgeon Bay. Born in Champaign, Illinois, in 1962, Trenchard earned her BFA in painting from Illinois State University in 1984. Subsequently, she and glass artist husband Jeremy Popelka relocated to San Francisco, California, where Trenchard designed textile patterns, licensed and sold under a private label. Upon returning to Sturgeon Bay Wisconsin in 1997, the couple built a hot shop and gallery that they share to this day. They assist each other with work as well as teaching projects, such as their recent classes in Thailand. As she assisted Popelka, Trenchard began to see glass casting as a means of translating textile patterns and other imagery to glass. The discovery of Paradise Paints allowed her to combine painting skills with glass art in the development of her award-winning body of work. Trenchard has developed a unique method of creating art using glass combined with paint. She first creates fully realized figures or objects in clear glass, which are then painted with high-fire enamels that are mixed and blended just as with oil or acrylic paints. Next, these three-dimensional objects or figures are submerged into molten glass encased in cubes and rectangles of clear sand cast glass. Each cube or rectangle is created so that they can be fitted tightly next to one another or on top, making a totem like structure. Coldworking is required to achieve the perfect fit. She states: “I have been following my own interests and curiosities concerning how these women have navigated their careers and artistic practices. I represent these ideas in glass through the details that speak to me, particularly the ephemera of material culture, furniture and clothing that encapsulate their era and class. I also rely on posture and facial expression to reveal the nature of the subject as I intuit it.” In addition to teaching in her studio, Trenchard has taught workshops at Pratt Fine Art Center, University of Wisconsin, The Studio at the Corning Museum of Glass, The Bergstrom Mahler Museum of Glass and others. She was a lecturer at the Glass Art Society Conference, Murano, Italy, and established the first hot glass school in Southeast Asia, at Bangkok Glass, Thailand. Recent exhibitions include: Beyond Giving, Inspiring Change, Singapore Art Week, Singapore; Matriarchs of Mastery, Habatat Gallery, Detroit, Michigan; A Creative Place, Trout Museum, Wisconsin; and Beyond the Ceiling – Women of Studio Glass, Sarasota, Florida, Habatat Invitational, Michigan. Awards include Trenchard's 2025 Featured Poet award, presented by After Hours Journal, Chicago; 2023, 2024 Prize Winner at Habatat International Exhibition; and the 2020 AACG Wisconsin Artist Series at Bergstrom-Mahler Museum of Glass. Says Trenchard: “Telling stories is what cultures do to understand the history and identities of the people. The small details in my work open up a conversation about the personal experiences of women in the arts as interpreted through history.”  

Consumer Finance Monitor
Everything You Want to Know About the CFPB as Things Stand Today, and Lots More - Part 2

Consumer Finance Monitor

Play Episode Listen Later Apr 17, 2025 52:12


Our podcast show being released today is part 2 of a repurposed interactive webinar that we presented on March 24 featuring two of the leading journalists who cover the CFPB - Jon Hill from Law360 and Evan Weinberger from Bloomberg. Our show begins with Tom Burke, a Ballard Spahr consumer financial services litigator, describing in general terms the status of the 38 CFPB enforcement lawsuits that were pending when Rohit Chopra was terminated. The cases fall into four categories: (a) those which have already been voluntarily dismissed with prejudice by the CFPB; (b) those which the CFPB has notified the courts that it intends to continue to prosecute; (c) those in which the CFPB has sought a stay for a period of time in order for it to evaluate whether or not to continue to prosecute them where the stay has been granted by the courts; and (d) those in which the CFPB's motion for a stay has been denied by the courts or not yet acted upon. Alan Kaplinsky then gave a short report describing a number of bills introduced this term related to the CFPB. Alan remarked that the only legislative effort which might bear fruit for the Republicans is to attempt to add to the budget reconciliation bill a provision subjecting the CFPB to funding through Congressional appropriations. Such an effort would need to be approved by the Senate Parliamentarian. Finally, Alan expressed surprise that the Republicans, in seeking to shut down the CFPB, have not relied on the argument that the CFPB has been unlawfully funded by the Federal Reserve Board since September 2022 because there has been no “combined earnings of the Federal Reserve Banks” beginning then through the present. (Dodd-Frank stipulates that the CFPB may be funded only out of such “combined earnings”). For more information about that funding issue, listen to Alan's recent interview of Professor Hal Scott of Harvard Law School who has written prolifically about it. On Monday of this week, Professor Scott published his third op-ed in the Wall Street Journal, in which he concluded: “Since the bureau is operating illegally, the president can halt its work immediately by executive order. The order should declare that all work at the CFPB will stop, that all rules enacted since funding became illegal in September 2022 are void, and that no new rules will be enforced.” Joseph Schuster then briefly described what has been happening at other federal agencies with respect to consumer financial services matters. Joseph and Alan reported on the fact that President Trump recently fired without cause the two Democratic members of the Federal Trade Commission leaving only two Republican members on the Commission. He took that action despite an old Supreme Court case holding that the language in the FTC Act stating that the President may remove an FTC member only for cause does not run afoul of the separation of powers clause in the Constitution.  The two Democratic commissioners have sued the Administration for violating the FTC Act provision, stating that the President may only remove an FTC commissioner for cause. The President had previously fired Democratic members at the Merit Systems Selection Board and National Labor Relations Board. President Trump based his firings on the belief that the Supreme Court will overrule the old Supreme Court case on the basis that the “termination for cause” language in the relevant statutes is unconstitutional. After the recording of this webinar, the DC Circuit Court of Appeals stayed, by a 2-1 vote, a District Court order holding that Trump's firing of the Democratic members of the NLRB and Merit Systems Selection Board was unlawful. That order was subsequently overturned by the court of appeals acting en banc. Subsequently, Chief Justice Roberts stayed that order. In light of these developments, it seems unlikely that the two FTC commissioners will be reinstated, if at all, until the Supreme Court decides the case. Also, after the recording of this webinar, the Senate confirmed a third Republican to be an FTC commissioner. For those of you who want a deeper dive into post-election developments at federal agencies other than the CFPB, please register for our webinar titled “What Is Happening at the Federal Agencies (Other Than the CFPB) That is Relevant to the Consumer Financial Services Industry?” which will occur on May 13, 2025. Joseph then discussed developments at the FDIC where the FDIC withdrew the very controversial brokered deposits proposal, the 2023 corporate governance proposal, the Change-in-Bank- Control Act proposal and the incentive-based compensation proposal. He also reported that the FDIC rescinded its 2024 Statement of Policy on Bank Merger Transactions and delayed the compliance date for certain provisions in the sign and advertising rule.  Joseph then discussed developments at the OCC where it (and the FDIC) announced that it would no longer use “reputation risk” as a basis for evaluating the safety and soundness of state-chartered banks that it supervises. The OCC, also, conditionally approved a charter for a Fintech business model to be a national bank and withdrew statements relating to crypto currency risk. Finally, Joseph discussed how state AGs and departments of banking have significantly ramped up their enforcement activities in response to what is happening at the CFPB. The podcast ended with each participant expressing his view on what the CFPB will look like when the dust settles. The broad consensus is that the CFPB will continue to operate with a greatly reduced staff and will only perform duties that are statutorily required. It is anticipated that there will be very little rulemaking except for rules that the CFPB is required to issue - namely, the small business data collection rule under 1071 of Dodd-Frank and the open banking rule under 1033 of Dodd-Frank. The panel also felt that the number of enforcement lawsuits and investigations will measurably decline with the focus being on companies engaged in blatant fraud or violations of the Military Lending Act. This podcast show was hosted by Alan Kaplinsky, the former practice group leader for 25 years and now senior counsel of the Consumer Financial Services Group. If you missed part 1 of our repurposed webinar produced on March 24, click here for a blog describing its content and a link to the podcast itself. In short, part 1 featured Jon Hill from Law360 and Evan Weinberger from Bloomberg, who chronicle the initiatives of CFPB Acting Directors Scott Bessent and Russell Vought and DOGE to dismantle the CFPB and the status of the two lawsuits brought to enjoin those initiatives. Ballard Spahr partners John Culhane and Rich Andreano give a status report on the effort of Acting Director Vought to nullify most of the final and proposed rules and other written guidance issued by Rohit Chopra. The podcast concludes with John and Rich describing the fact that supervision and examinations of banks and non-banks is non-existent.

The Bangkok Podcast | Conversations on Life in Thailand's Buzzing Capital
Myanmar Quakes & Bangkok Shakes: Thoughts on the March 28 Earthquake [S7.E65]

The Bangkok Podcast | Conversations on Life in Thailand's Buzzing Capital

Play Episode Listen Later Apr 8, 2025 35:41 Transcription Available


Greg and Ed address the unavoidable topic du jour: the earthquake that struck Myanmar on March 28 that was felt all the way to Bangkok. Greg begins by pointing out that even though much ink and many words have already been spilled on the topic, listeners may be concerned about traveling to Bangkok now or the safety of Bangkok's buildings in general. They guys decide to do their civic duty and chime in. First, they relate their personal stories - Ed was at home first thought he was getting dizzy (and old) but after realizing it was an earthquake mainly went about his day as normal. Greg was in his office when it hit, and he and his colleagues calmly evacuated the building. Subsequently, they both experienced the insane traffic conditions - Ed took an hour and 45 minutes to get from Khao San to Thong Lor and Greg took almost three hours to get from his office in Hua Mak to his home in Thonburi. Ouch! Lesson: when the BTS and MRT shut down, stay off the roads as much as possible.