Podcasts about characterisation

Shamble, sprint, or rage your way into this week's episode of Podcast Assemble! The boys are back with recommendations for Taika Waititi's 'Jojo Rabbit', and recommending against the new Robert De Niro vehicle 'Alto Knights'. Then it's on to the long-awaited, possibly unasked-for sequel: '28 Years Later'.Timecodes:(0:00:22) - Intro(0:01:54) - What's been happening?(0:07:58) - What have you been up to? (0:24:05) - Main topic NON SPOILERS(0:35:45) - ATJ's Mid-Life Crisis(0:40:00) - The Alpha's/ World Building(0:42:10) - Characterisation(0:54:10) - Tones & Themes(0:56:04) - 3 Best & 3 Worst(0:58:25) - Critical Reception(0:59:42) - Better or Worse than Aquaman (2018)(1:00:00) - SPOILERS(1:10:00) - Trivial True or False(1:13:35) - Wrap UpMain Topic:28 Years Later rises from the cinematic grave continuing the outbreak, with a new cast, and the same old trust issues. Set in a world where rage never really died out (relatable), this latest chapter asks what's worse: the infected... or the survivors. The film trades quiet dread for large-scale dread; DL welcomes the bleakness and Tommy's here to confirm running zombies are still terrifying.Is 28 Years Later the return to form fans have been dying for—or just another reanimated IP? Let us know at thepodcastassemble@gmail.com or hit us up on socials. Bonus points if you can explain what Ghost actually does.Website || Instagram || Twitter || YouTube || Email****************************And while we've got you, we'd love it if you gave us a 5 star review ⭐️⭐️⭐️⭐️⭐️ and let us know what you think of the show.#28YearsLater #ArronTaylorJohnson #Zombies #Horror #DannyBoyle #podcast #MovieReview

Lots of game, tv and movie discussion this week as we talk Metroid Prime 4, Pillars of Eternity, Silent Hill F, Atomfall, The Legend of Zelda movie, Rust, Snow White, Ludwig, Paradise, Common Side Effects and some other stuff too!Metroid Prime 4, baby! - https://www.vg247.com/metroid-prime-4-beyond-shows-up-at-nintendo-direct-and-shows-off-samus-mind-bending-psychic-abilitiesPillars of Eternity is getting turn based combat, 10 years after release! - https://arstechnica.com/gaming/2025/03/pillars-of-eternity-is-getting-turn-based-combat-all-but-demanding-replays/Silent Hill F refused classification down unda - https://www.darkhorizons.com/silent-hill-f-refused-classification-in-australia/The Legend of Zelda - https://www.darkhorizons.com/legend-of-zelda-film-hits-march-2027/Rust trailer - https://www.darkhorizons.com/first-trailer-alec-baldwin-in-rust/Snow White is performing... poorly - https://www.darkhorizons.com/a-closer-look-at-the-snow-white-disaster/

hVIVO PLC (AIM:HVO) chief scientific officer Dr Andrew Catchpole talked with Proactive's Stephen Gunnion about the company's recent success in developing a human challenge model for human metapneumovirus (hMPV). Catchpole highlighted the pilot characterisation study, which showed clear viral infection curves, strong symptom visibility, and ensured safety for volunteers. He explained that hMPV, a significant respiratory pathogen affecting young children and the elderly, shares similarities with influenza and RSV. With this new challenge model, hVIVO now offers a powerful tool for fast-tracking the development of vaccines and antiviral therapies for hMPV. Catchpole said: “Human challenge trials are the fastest way to get efficacy data... you just can't do this in field trials.” Moreover, he discussed encouraging progress in hMPV vaccine research, building on RSV-related breakthroughs. The data from this study will also be presented at an upcoming RSV conference in Brazil, shedding light on immune responses and potential treatment paths. Visit Proactive's YouTube channel for more updates, and don't forget to like the video, subscribe, and turn on notifications to stay informed. #hVIVO #hMPV #HumanChallengeTrial #VaccineDevelopment #RespiratoryViruses #ClinicalResearch #ProactiveInvestors

In episode 97 of “How Do You Say That?!” sponsored by Voxbox, Jonathan Kydd joins Sam and Mark to talk about creating characters, a beloved little bear with a marmalade sandwich, and what to do with a list!Our VO question this week is all about how the industry has changed, and what you definitely should do when you're in a live session!Get involved! Have you got a Wildcard suggestion that we should try or an idea for the show? Send it to us via Mark or Sam's social media or email it directly to podcast@britishvoiceover.co.ukScript 1Let's start by accepting and highlighting three basic, concrete, and absolutely undeniable premises: 1. Everyone, without exception, has felt fear at some point in the past. 2. Everyone, without exception, continues to feel fear, often and on many occasions, in the present. 3. Everyone, without exception, will continue to feel fear in the future. All human beings (in fact, all living beings) feel fear. Fear is absolutely necessary. Repeat after me: Fear is absolutely necessary. Script 2PADDINGTONEr, hello. I'm Paddington, Mr Curry's neighbour. He isn't here right now. And, uh…BILL(can't believe their luck)The house is empty? Why, Fred, it's perfect!FREDPerfectly bad luck, you mean.(to Paddington)We're Mr Curry's distant cousins. We're paying him a visit.PADDINGTONOh, what a relief! Uh… I mean how nice, do come in.This is the sitting room.Here.I'll go and make some tea. You sit down and make yourselves comfortable.**Listen to all of our podcasts here - you can also watch on YouTube, or say to your smart speaker "Play How Do You Say That?!"About our guest: Jonathan Kydd has been voicing since 1986. He's done over twenty thousand ads, corporates, documentaries, video games and animations. He played Hagrid in all the Harry Potter games, played Paddington in 79 Episodes of Paddington Bear, was the voice of L'Oreal for seven years, and the voice behind the iconic Fererro Rocher Ambassador ad!Jonathan's worked for the BBC, Pepsi, Shake n Vac, the Guardian, ... the list of blue chip clients goes on and on... He's voiced hundreds of documentaries including 8 series of Airport Security and lots of dinosaur and shark specials for Nat Geo. He's been the voice of quite a few inanimate objects, and also hosts a podcast about football! Jonathan's WebsiteResources:Check out our sponsor Voxbox - the portable, foldable, storable audio booth.https://www.voxbox.studio/ Now you can get 10% off a Voxbox by using the code HDYST24Click here for the Wildcard Generator and don't forget to think of an action your character can be doing!

The Exocast team are joined on this show by Dr. Néstor Espinoza from the Space Telescope Science Institute (STScI) in Baltimore, USA. Néstor is an Assistant Astronomer and Mission Scientist for Hubble and JWST at STScI, where he focusses on transiting exoplanets and their stars. He also provides support for HST and JWST as Mission Scientist for Exoplanet Science in the Instrument Division, and Néstor speaks to the Exocast gang about balancing these distinct roles,Read more

Labour's Local Government spokesman's pushed back on the Prime Minister's characterisation of councils across the country. On Wednesday, Chris Luxon launched a broadside against local government -- telling them to get back to basics with theirs spending. Chris Hipkins today apologised to councillors and mayors for the PM's attack; and Kieran McAnulty told Heather du Plessis-Allan that Luxon was out of line. He says what Luxon said was patronising and wrong, and it's the Government that sets the system that the Councils have to work in. LISTEN ABOVE    See omnystudio.com/listener for privacy information.

hVIVO Chief Executive Officer Mo Khan joined Steve Darling from Proactive to share significant news about the company's latest developments. hVIVO has signed a £2.5 million contract with a mid-sized pharmaceutical company to initiate an Omicron characterisation study. The manufacturing of hVIVO's Omicron BA.5 challenge agent was successfully completed in 2023. Khan explained that the study aims to identify a dose of hVIVO's Omicron BA.5 challenge agent that can establish a safe, measurable, and reproducible disease in healthy volunteers aged 18-30. The goal is to achieve sufficiently high infection rates to use this model for testing the efficacy of antivirals and vaccines in the future. The study is expected to commence in Q4 2024, with the majority of revenue recognized in 2025. It will be conducted at the company's new CL3 quarantine facility at Canary Wharf. This state-of-the-art facility has been specifically designed to meet the highest hospital isolation suite standards suitable for CL3 pathogens. It is equipped with advanced safety features, including physical containment barriers, controlled ventilation systems with negative pressure and HEPA filtration, and comprehensive waste management protocols. This will be the first COVID-related human challenge study that hVIVO will undertake since the contract announcement in June 2022. The study represents a significant step forward in understanding and combating the Omicron variant of the virus, contributing valuable data for the development of effective treatments and vaccines. Khan highlighted the importance of this contract for hVIVO, emphasizing the company's leading role in the field of human challenge studies. The successful completion of this study will not only advance scientific knowledge but also reinforce hVIVO's reputation as a pioneer in the development of innovative solutions for infectious diseases. In conclusion, hVIVO's £2.5 million contract for the Omicron characterisation study marks a pivotal moment for the company. With its advanced CL3 quarantine facility and proven expertise in human challenge studies, hVIVO is well-positioned to make significant contributions to the fight against COVID-19 and other infectious diseases. The study's findings are expected to play a crucial role in the development of new antivirals and vaccines, ultimately helping to safeguard public health #proactiveinvestors #hvivoplc #aim #hvo #clinicaltrial #antiviralcandidate #humanchallengestudy #biotechnology #rhinovirus #medicalresearch #humantesting #viralload #pharmaceuticals #medicalstudies #clinicalasset #clinicalcontact #invest #investing #investment #investor #stockmarket #stocks #stock #stockmarketnews

This week we celebrate Star Wars with a fabulous short portraying the infamous AT-AT death walkers as 'nature-creatures' in their natural habitat - this is a beautifully observed work, made in Unreal Engine by Jeremy Cummins.  Cummins is an experienced character creator, now working for Tippett Studio, with an impressive list of credits including Ant-Man and the Wasp, Spider-Man and Avengers, among others.  We discuss the transition pros are making in the development of an Unreal pipeline and the impact this has on the creative machinima community.  0:44 Intro to the film3:18 About Jeremy Cummins4:33 Developing the pipeline5:36 PhantomFX takes over Tippett Studios, what are the implications?7:01 Migration – in the film, and metaphorically8:59 Stunning lighting effects9:18 Characterisation of AT-ATs – itchy and goofy!10:27 Sound effects inconsistent? Cows vs dino vs croc = buff… nah12:14 Who's got a sub to Galactic Geographic?13:50 Humour and the portrayal of death dealing machines15:00 The ambient sound needed a bit more work to achieve verisimilitude16:06 Check out Pie in the Sky too – and why it's a better film17:47 Tapping into a ‘magical movie moment' in time, anthropomorphism and our fascination with machines as animals in the Star Wars universe20:00 Communicating size with sound22:34 Length of the film24:00 Excitement: AT-ATs were only ever seen for such a short length of time in the original canon, so how cool to see them again!26:30 A perfect example of contemporary realtime cinemaCredits -Speakers: Ricky Grove, Phil Rice, Damien Valentine, Tracy HarwoodProducer: Damien ValentineEditor: Phil RiceMusic: Animo Domini Beats

Discover the magic that unfolds when setting takes center stage in a novel, transforming lifeless backdrops into dynamic entities with a soul of their own. This week, best-selling author Danny Petrie joins me, Wendy H Jones, to unravel the secrets behind crafting settings that captivate and characters who resonate with readers like old friends. Amidst the rugged Alaskan wilderness and the vibrant streets of Santa Fe, we delve into the art of choosing the perfect locale to reflect the essence of our stories, and how these choices impact every twist and turn of the narrative.As an author who loves to sketch out the bones of dialogue and action, I share my unique process of dressing these bare frameworks with the flesh of immersive settings. Danny and I discuss the balance required to maintain narrative momentum without sacrificing the rich tapestry of descriptive detail that brings a world to life—especially crucial in genres where the stakes are high, and the suspense is thicker than fog. Our talk is a celebration of storytelling, marked by the release of "One Wrong Move," a novel that epitomizes the harmony of setting and plot in a thrilling dance of intrigue.To all fellow writers and fervent readers, our conversation is a tribute to the craft that unites us. I offer gratitude for your unwavering support and invite you to join the community that fosters these insightful dialogues. Your patronage on Patreon ensures the continuity of this creative exchange, and for that, I thank you. Remember, the journey continues next week with another inspiring guest, and I eagerly anticipate sharing more wisdom that lights the path for your literary adventures.

Have you ever faced a character in a book so flat they seem to fall off the page? Fear not, fellow wordsmiths, for I, Wendy H Jones, am here to share the secret sauce to spicing up your characters! This episode of the Writing and Marketing Show is a treasure trove of insights into the subtle art of characterisation. From the lush setting of Wester Wootatelle and Spa to the vibrant aisles of the London Book Fair, I take you on a whirlwind tour of a writer's life, replete with the unexpected twists that demand a nimble mind and a flexible pen.Characterisation isn't just about crafting a biography; it's about breathing life into your protagonists and antagonists with a finesse that makes them leap off the page and into readers' hearts. I delve into the nuances of showing emotions, why a tapping finger can speak volumes more than an exclaimed "I'm frustrated!", and how varying word choices can transform a mere description into an experience. Danny Petrie may not join us this time around, but the conversation doesn't lack for depth, exploring everything from evocative verbs to avoiding the pitfalls of emotional repetition.Finally, I pull back the curtain on what's ahead and where you can join this literary journey with me. Humor mingles with earnest advice as I navigate the everyday chaos of a husky's treat-time amidst musings on character flaws and dialogue pauses. The promise of next week's special guest lingers enticingly as I bid you adieu, inviting you to stay connected and continue fostering your love for the written word. Remember, the stories we craft are as alive as we make them, so let's keep the pages turning and the ink flowing.

Metal Gear Solid 2 was easily the most hotly anticipated game for the Playstation 2.  The first game had blown everyone away, and the jaw-dropping graphics of previews combined with the quality of the animation in cutscenes seemed almost too good to be true.  Luckily for fans everywhere, MGS 2 appeared to live up to its wild expectations, getting almost universally glowing reviews.  It seemed that MGS 2 had expanded upon the first game in every single way, including having an even more convoluted story.  But for all its praise, there were hints of critique and backlash around the edges if you looked hard enough.  The change of protagonist definitely pissed a lot of people off, and opinion was divided over whether the ending was brilliant or just a self indulgent mess of ideas awkwardly stapled together.So is Metal Gear Solid 2 still a game worth playing today?  Or are there flaws in this acclaimed classic that have been long forgotten?On this episode we discuss:Gameplay.In what ways has the core mechanics of sneaking around a complex changed from Metal Gear Solid 1 to 2?  Are these differences meaningful in changing how you engage with the game, or are they just surface level changes with murdering enemies at range with a silenced pistol still being the best approach?Characterisation.One of the most memorable parts of the original Metal Gear Solid was its wacky roster of villains, all with their own questionably fantastical super powers.  Does MGS 2 continue this proud tradition, or are the enemy bosses in the game lacklustre in comparison?Story.To call Metal Gear Solid 2's story complicated is a massive understatement.  To what degree does it manage to hold together its threads of conspiracy, philosophy and free will?  Does it all come together in a cohesive whole, or is it just a load of nonsense?We answer these questions and many more on the 112th episode of the Retro Spectives Podcast! Intro Music: KieLoBot - Tanzen KOutro Music: Rockit Maxx - One point to anotherMetal Gear Solid 2 OST: Harry Gregson-Williams, Norihiko Hibino What was your favourite part of Metal Gear Solid 2?  Does Fortune get as much hate as she deserves, or should she get even more?  Which stealth game should we play next?  Come let us know what you think on our community discord server!You can support the show monetarily on our Buy me a Coffee Page!    

In the first episode, Solomon Tesfaye and Ollie Binns-Hall explore the pressing issue of the diabetes epidemic and its most prevalent microvascular complication: neuropathy. They discuss the identification and characterisation of these critical aspects of diabetes and explore the causes, symptoms, and challenges of diagnosing neuropathy within the broader context of diabetes.   This content has been supported by Viatris

Join Luke, Elliot and our super special guests Nidula and Julia of Cactus Jam Games as we discuss characterisation in video games! The team chats with our special guests about... LEARN MORE The post Video Game Characterisation with special guests Nidula and Julia! appeared first on Checkpoint.

Today I have another of my conversations with a friend within the roleplaying games community. This episode we dipped into talking about characterisation in our RPGs, especially around NPCs. My guest, Simon Williams, is a British artist and illustrator as well as being the creator of the Legend of The Bones podcast, a hybrid Solo Old School Dungeons and Dragons actual play and dark fantasy audio drama. Big thanks to Simon for coming back to the show!Legend of The Bones Podcast:https://legendofthebones.podbean.com/Game on!Roleplay Rescue Details:Voice Message:speakpipe.com/roleplayrescuePatreon:patreon.com/rpgrescue Email:hello@rpgrescue.comBlog:roleplayrescue.com Mastodon:@UbiquitousRat@ttrpg-hangout.socialRoleplay Rescue Theme by Jon Cohen from Tale of the Manticore:https://taleofthemanticore.podbean.com/ Hosted on Acast. See acast.com/privacy for more information.

Today I have another of my conversations with a friend within the roleplaying games community. This episode we dipped into talking about characterisation in our RPGs, especially around NPCs. My guest, Simon Williams, is a British artist and illustrator as well as being the creator of the Legend of The Bones podcast, a hybrid Solo Old School Dungeons and Dragons actual play and dark fantasy audio drama. Big thanks to Simon for coming back to the show!Legend of The Bones Podcast:https://legendofthebones.podbean.com/Game on!Roleplay Rescue Details:Voice Message:speakpipe.com/roleplayrescuePatreon:patreon.com/rpgrescue Email:hello@rpgrescue.comBlog:roleplayrescue.com Mastodon:@UbiquitousRat@ttrpg-hangout.socialRoleplay Rescue Theme by Jon Cohen from Tale of the Manticore:https://taleofthemanticore.podbean.com/ Hosted on Acast. See acast.com/privacy for more information.

Remember all those articles about microplastics in human milk last year? Well your friends at the Milk Minute are finally tackling the topic.Why is this happening? Can we do anything to change it? Should we be worried?Tune in this week to hear all that and more as Heather and Maureen pick apart the tricky topic of microplastic contamination in the human body.Work With Us!Book a Lactation Consult with Heather! Click HERE for the deets.Book a Lactation Consult with Maureen! Click HERE to get started.THANK YOU TO OUR PATRON, Anna from Maine!THANK YOU TO THIS EPISODE'S SPONSORSGet your breastfeeding journey BACK ON TRACK with a Lactation Consult with Heather! Telehealth available and some insurance accepted. Click HERE for the deets. If you have Blue Cross Blue Shield, Anthem, Cigna PPO or Provider Network of America– you can fill out a short form to get pre-approval to get your visits with Heather 100% approved! Click HERE to access the form.Ceres Chill - Grab your Ceres Chiller or Milkstache HERE and enter promo code MILKMINUTE15 for 15% off!Click HERE to save 25% off and free shipping on all Liquid IV products with the code MILK_MINUTEListener Question: My exclusively breastfed almost 4-month-old is suddenly refusing her pacifier. Any tips to get her to use it when she's upset but not hungry? It seems that lately nothing will calm her down other than the boob.Sources:Plastic Debris in the Marine Environment: History and Future Challenges - PMC (nih.gov)Raman Microspectroscopy Detection and Characterisation of Microplastics in Human Breastmilk - PMC (nih.gov)Microplastics found in human breast milk for the first time | Plastics | The GuardianPlastic production worldwide 2021 | StatistaMicroplastics in infant milk powder - PubMed (nih.gov)Read the episode transcript HEREGet 20% off your Mother's Day Gourmet Brownies from the Brownie House by entering code MILKMINUTE20 and ordering from this link: https://shop.yesbrownies.com/discount/MILKMINUTE20Support the showCheck out Milk Minute Podcast's website here!Become a VIP Click here to get exclusive access and more!Send us an e-mail! MilkMinutePodcast@gmail.comFacebook | Instagram | TikTok

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.30.534946v1?rss=1 Authors: Hutchins, J. R. A., Peiffer, I., Urbach, S., Mergny, J.-L., Marin, P., Maiorano, D., MECHALI, M. Abstract: In metazoan cells, replication of genomic DNA initiates from thousands of discrete chromosomal loci known as origins. Proteins such as the Origin Recognition Complex (ORCs) associate with origins, but this does not show clear sequence specificity for DNA binding. Genome-wide origin mapping studies have shown that the region surrounding the replication initiation site contains motifs such as the Origin G-rich Repeated Element (OGRE), proximal to the majority of origins. Here, using an approach coupling DNA affinity purification to quantitative proteomics, we identified proteins that interact specifically with an OGRE. Three of the top-scoring interactors, Dhx36, Pura and Tial1, were selected for further study. We show that Dhx36 and Tial1 localise to the nucleus and their knockdown decreased cells in S-phase resulting in their accumulation in the G1 phase of the cell cycle. Altogether these results indicate that these OGRE-binding factors may play roles in DNA synthesis in mammalian cells. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Geopolitiske spenninger har satt en stopper for videre forskning på SARS-CoV-2s opprinnelse. Men den gode nyheten er at under Kinas siste bølge av covid-19 har det ikke blitt funnet noen nye varianter av viruset. Hvordan sto det til med barns skjermbruk fra juni 2019 til august 2021? Hvordan påvirker såkalt longcovid sysselsettingen? Det foreligger dessuten nå mer forskning på dødelighet blant leger under pandemien. Åtte land har bekjempet en tropisk infeksjonssykdom i løpet av 2022. Du får også høre om forskning på brystkreft og på hjerneslag, og på effekten av treplanting i urbane områder for å senke temperaturen og dermed begrense hetebølger. Og har vi kommet ett skritt nærmere tankekontroll for pasienter med alvorlige lammelser – uten å operere inn implantater i hjernen? Sjefredaktør Are Brean deler siste nytt fra andre vitenskapelige tidsskrifter den siste tiden. Tilbakemeldinger kan sendes til stetoskopet@tidsskriftet.no.    Stetoskopet produseres av Synne Muggerud Sørensen, Sigurd Ziegler, Are Brean og Julie Didriksen ved Tidsskrift for Den norske legeforening. Ansvarlig redaktør er Are Brean.   Jingle og lydteknikk: Håkon Braaten / Moderne media   Coverillustrasjon: Stephen Lee   Artikler nevnt:   WHO abandons plans for crucial second phase of COVID-origins investigation Characterisation of SARS-CoV-2 variants in Beijing during 2022: an epidemiological and phylogenetic analysis - The Lancet Trends in Screen Time Use Among Children During the COVID-19 Pandemic, July 2019 Through August 2021 Excess Mortality Among US Physicians During the COVID-19 Pandemic Association of Post–COVID-19 Condition Symptoms and Employment Status Long COVID Linked With Unemployment in New Analysis Bird Flu Has Begun to Spread in Mammals—Here's What's Important to Know Eight countries eliminated a neglected tropical disease in 2022 Breast-Conserving Surgery with or without Irradiation in Early Breast Cancer Overcoming Resistance — Omission of Radiotherapy for Low-Risk Breast Cancer Endovascular Therapy for Acute Stroke with a Large Ischemic Region Improved Prospects for Thrombectomy in Large Ischemic Stroke Trial of Endovascular Thrombectomy for Large Ischemic Strokes Trial of Endovascular Therapy for Acute Ischemic Stroke with Large Infarct Cooling cities through urban green infrastructure: a health impact assessment of European cities Assessment of Safety of a Fully Implanted Endovascular Brain-Computer Interface for Severe Paralysis in 4 Patients: The Stentrode With Thought-Controlled Digital Switch (SWITCH) Study

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.29.518315v1?rss=1 Authors: Frorup, C., Gerwig, R., Sondergaard Svane, C. A., Mendes Lopes de Melo, J., Floyel, T., Pociot, F., Kaur, S., Storling, J. Abstract: ObjectiveEndoC-{beta}H5 is a newly established human beta-cell model which may be superior to previous models of native human beta cells. Exposure of beta cells to proinflammatory cytokines is a widely used in vitro model of immune-mediated beta-cell failure in type 1 diabetes and we therefore performed an in-depth characterisation of the effects of cytokines on EndoC-{beta}H5 cells. MethodsThe sensitivity profile of EndoC-{beta}H5 cells to the toxic effects of the pro-inflammatory cytokines interleukin-1{beta} (IL-1{beta}), interferon {gamma} (IFN{gamma}) and tumour necrosis factor- (TNF) was examined in titration and time-course experiments. Cell death was evaluated by caspase 3/7 activity, cytotoxicity, viability, TUNEL assay and immunoblotting. Mitochondrial function was evaluated by extracellular flux technology. Activation of signalling pathways and major histocompatibility complex (MHC) class I expression were examined by immunoblotting, immunofluorescence, and real-time quantitative PCR (qPCR). Glucose-stimulated insulin secretion (GSIS) and cytokine-induced chemokine secretion were measured by ELISA and Meso Scale Discovery multiplexing electrochemiluminescence, respectively. Global gene expression was characterised by stranded RNA sequencing. ResultsCytokines increased caspase activity and cytotoxicity in EndoC-{beta}H5 cells in a time- and dose-dependent manner. The proapoptotic effect of cytokines was primarily driven by IFN{gamma}. Cytokine exposure caused impaired mitochondrial function, diminished GSIS, and induced secretion of chemokines. At the signalling level, cytokines increased the phosphorylation of signal transducer and activator of transcription 1 (STAT1) but not c-jun N-terminal kinase (JNK) and did not cause degradation of nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor (I{kappa}B). MHC class I was induced by cytokines. Cytokine exposure caused significant changes to the EndoC-{beta}H5 transcriptome including upregulation of HLA genes, endoplasmic reticulum stress markers, and non-coding RNAs. Among the differentially expressed genes were several type 1 diabetes risk genes. ConclusionsOur study provides detailed insight into the functional and transcriptomic effects of cytokines on EndoC-{beta}H5 cells. This knowledge will be helpful for future investigations studying cytokine effects in this cell model. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Characterisation of the MUSIC ASIC for large-area silicon photomultipliers for gamma-ray astronomy by Nicolas De Angelis et al. on Tuesday 29 November Large-area silicon photomultipliers (SiPMs) are desired in many applications where large surfaces have to be covered. For instance, a large area SiPM has been developed by Hamamatsu Photonics in collaboration with the University of Geneva, to equip gamma-ray cameras employed in imaging atmospheric Cherenkov telescopes. Being the sensor about 1 cm$^2$, a suitable preamplification electronics has been investigated in this work, which can deal with long pulses induced by the large capacitance of the sensor. The so-called Multiple Use SiPM Integrated Circuit (MUSIC), developed by the ICCUB (University of Barcelona), is investigated as a potential front-end ASIC, suitable to cover large area photodetection planes of gamma-ray telescopes. The ASIC offers an interesting pole-zero cancellation (PZC) that allows dealing with long SiPM signals, the feature of active summation of up to 8 input channels into a single differential output and it can offer a solution for reducing power consumption compared to discrete solutions. Measurements and simulations of MUSIC coupled to two SiPMs developed by Hamamatsu are considered and the ASIC response is characterized. The 5$^{th}$ generation sensor of the Low Cross Talk technology coupled to MUSIC turns out to be a good solution for gamma-ray cameras. arXiv: http://arxiv.org/abs/http://arxiv.org/abs/2211.14022v2

Characterisation of the MUSIC ASIC for large-area silicon photomultipliers for gamma-ray astronomy by Nicolas De Angelis et al. on Monday 28 November Large-area silicon photomultipliers (SiPMs) are desired in many applications where large surfaces have to be covered. For instance, a large area SiPM has been developed by Hamamatsu Photonics in collaboration with the University of Geneva, to equip gamma-ray cameras employed in imaging atmospheric Cherenkov telescopes. Being the sensor about 1 cm$^2$, a suitable preamplification electronics has been investigated in this work, which can deal with long pulses induced by the large capacitance of the sensor. The so-called Multiple Use SiPM Integrated Circuit (MUSIC), developed by the ICCUB (University of Barcelona), is investigated as a potential front-end ASIC, suitable to cover large area photodetection planes of gamma-ray telescopes. The ASIC offers an interesting pole-zero cancellation (PZC) that allows dealing with long SiPM signals, the feature of active summation of up to 8 input channels into a single differential output and it can offer a solution for reducing power consumption compared to discrete solutions. Measurements and simulations of MUSIC coupled to two SiPMs developed by Hamamatsu are considered and the ASIC response is characterized. The 5$^{th}$ generation sensor of the Low Cross Talk technology coupled to MUSIC turns out to be a good solution for gamma-ray cameras. arXiv: http://arxiv.org/abs/http://arxiv.org/abs/2211.14022v1

Characterisation of the MUSIC ASIC for large-area silicon photomultipliers for gamma-ray astronomy by Nicolas De Angelis et al. on Monday 28 November Large-area silicon photomultipliers (SiPMs) are desired in many applications where large surfaces have to be covered. For instance, a large area SiPM has been developed by Hamamatsu Photonics in collaboration with the University of Geneva, to equip gamma-ray cameras employed in imaging atmospheric Cherenkov telescopes. Being the sensor about 1 cm$^2$, a suitable preamplification electronics has been investigated in this work, which can deal with long pulses induced by the large capacitance of the sensor. The so-called Multiple Use SiPM Integrated Circuit (MUSIC), developed by the ICCUB (University of Barcelona), is investigated as a potential front-end ASIC, suitable to cover large area photodetection planes of gamma-ray telescopes. The ASIC offers an interesting pole-zero cancellation (PZC) that allows dealing with long SiPM signals, the feature of active summation of up to 8 input channels into a single differential output and it can offer a solution for reducing power consumption compared to discrete solutions. Measurements and simulations of MUSIC coupled to two SiPMs developed by Hamamatsu are considered and the ASIC response is characterized. The 5$^{th}$ generation sensor of the Low Cross Talk technology coupled to MUSIC turns out to be a good solution for gamma-ray cameras. arXiv: http://arxiv.org/abs/http://arxiv.org/abs/2211.14022v2

Characterisation of the MUSIC ASIC for large-area silicon photomultipliers for gamma-ray astronomy by Nicolas De Angelis et al. on Sunday 27 November Large-area silicon photomultipliers (SiPMs) are desired in many applications where large surfaces have to be covered. For instance, a large area SiPM has been developed by Hamamatsu Photonics in collaboration with the University of Geneva, to equip gamma-ray cameras employed in imaging atmospheric Cherenkov telescopes. Being the sensor about 1 cm$^2$, a suitable preamplification electronics has been investigated in this work, which can deal with long pulses induced by the large capacitance of the sensor. The so-called Multiple Use SiPM Integrated Circuit (MUSIC), developed by the ICCUB (University of Barcelona), is investigated as a potential front-end ASIC, suitable to cover large area photodetection planes of gamma-ray telescopes. The ASIC offers an interesting pole-zero cancellation (PZC) that allows dealing with long SiPM signals, the feature of active summation of up to 8 input channels into a single differential output and it can offer a solution for reducing power consumption compared to discrete solutions. Measurements and simulations of MUSIC coupled to two SiPMs developed by Hamamatsu are considered and the ASIC response is characterized. The 5$^{th}$ generation sensor of the Low Cross Talk technology coupled to MUSIC turns out to be a good solution for gamma-ray cameras. arXiv: http://arxiv.org/abs/http://arxiv.org/abs/2211.14022v1

Towards a new era in giant exoplanet characterisation by Simon Müller et al. on Thursday 24 November Determining the composition of giant exoplanets is crucial for understanding their origin and evolution. However, the planetary bulk composition is not measured directly but must be deduced from a combination of mass-radius measurements, knowledge of the planetary age and evolution simulations. Accurate determinations of stellar ages, mass-radius, and atmospheric compositions from upcoming missions can significantly improve the determination of the heavy-element mass in giant planets. In this paper, we first demonstrate the importance of an accurate age measurement, as expected from Plato, in constraining the planetary properties. Well-determined stellar ages can reduce the bulk-metallicity uncertainty up to about a factor of two. We next infer the bulk metallicity of warm giants from the Ariel mission reference sample and identify the Ariel high-priority targets for which a measured atmospheric metallicity can clearly break the degeneracy in the inferred composition. We show that knowledge of the atmospheric metallicity can broadly reduce the bulk-metallicity uncertainty by a factor of four to eight. We conclude that the accurate age determination from Plato and atmospheric measurements by Ariel and the James Webb Space Telescope will play a key role in revealing the composition of giant exoplanets. arXiv: http://arxiv.org/abs/http://arxiv.org/abs/2211.05468v2

Towards a new era in giant exoplanet characterisation by Simon Müller et al. on Thursday 24 November Determining the composition of giant exoplanets is crucial for understanding their origin and evolution. However, the planetary bulk composition is not measured directly but must be deduced from a combination of mass-radius measurements, knowledge of the planetary age and evolution simulations. Accurate determinations of stellar ages, mass-radius, and atmospheric compositions from upcoming missions can significantly improve the determination of the heavy-element mass in giant planets. In this paper, we first demonstrate the importance of an accurate age measurement, as expected from Plato, in constraining the planetary properties. Well-determined stellar ages can reduce the bulk-metallicity uncertainty up to about a factor of two. We next infer the bulk metallicity of warm giants from the Ariel mission reference sample and identify the Ariel high-priority targets for which a measured atmospheric metallicity can clearly break the degeneracy in the inferred composition. We show that knowledge of the atmospheric metallicity can broadly reduce the bulk-metallicity uncertainty by a factor of four to eight. We conclude that the accurate age determination from Plato and atmospheric measurements by Ariel and the James Webb Space Telescope will play a key role in revealing the composition of giant exoplanets. arXiv: http://arxiv.org/abs/http://arxiv.org/abs/2211.05468v2

Towards a new era in giant exoplanet characterisation by Simon Müller et al. on Wednesday 23 November Determining the composition of giant exoplanets is crucial for understanding their origin and evolution. However, the planetary bulk composition is not measured directly but must be deduced from a combination of mass-radius measurements, knowledge of the planetary age and evolution simulations. Accurate determinations of stellar ages, mass-radius, and atmospheric compositions from upcoming missions can significantly improve the determination of the heavy-element mass in giant planets. In this paper, we first demonstrate the importance of an accurate age measurement, as expected from Plato, in constraining the planetary properties. Well-determined stellar ages can reduce the bulk-metallicity uncertainty up to about a factor of two. We next infer the bulk metallicity of warm giants from the Ariel mission reference sample and identify the Ariel high-priority targets for which a measured atmospheric metallicity can clearly break the degeneracy in the inferred composition. We show that knowledge of the atmospheric metallicity can broadly reduce the bulk-metallicity uncertainty by a factor of four to eight. We conclude that the accurate age determination from Plato and atmospheric measurements by Ariel and the James Webb Space Telescope will play a key role in revealing the composition of giant exoplanets. arXiv: http://arxiv.org/abs/http://arxiv.org/abs/2211.05468v2

Towards a new era in giant exoplanet characterisation by Simon Müller et al. on Wednesday 23 November Determining the composition of giant exoplanets is crucial for understanding their origin and evolution. However, the planetary bulk composition is not measured directly but must be deduced from a combination of mass-radius measurements, knowledge of the planetary age and evolution simulations. Accurate determinations of stellar ages, mass-radius, and atmospheric compositions from upcoming missions can significantly improve the determination of the heavy-element mass in giant planets. In this paper, we first demonstrate the importance of an accurate age measurement, as expected from Plato, in constraining the planetary properties. Well-determined stellar ages can reduce the bulk-metallicity uncertainty up to about a factor of two. We next infer the bulk metallicity of warm giants from the Ariel mission reference sample and identify the Ariel high-priority targets for which a measured atmospheric metallicity can clearly break the degeneracy in the inferred composition. We show that knowledge of the atmospheric metallicity can broadly reduce the bulk-metallicity uncertainty by a factor of four to eight. We conclude that the accurate age determination from Plato and atmospheric measurements by Ariel and the James Webb Space Telescope will play a key role in revealing the composition of giant exoplanets. arXiv: http://arxiv.org/abs/http://arxiv.org/abs/2211.05468v2

Towards a new era in giant exoplanet characterisation by Simon Müller et al. on Wednesday 23 November Determining the composition of giant exoplanets is crucial for understanding their origin and evolution. However, the planetary bulk composition is not measured directly but must be deduced from a combination of mass-radius measurements, knowledge of the planetary age and evolution simulations. Accurate determinations of stellar ages, mass-radius, and atmospheric compositions from upcoming missions can significantly improve the determination of the heavy-element mass in giant planets. In this paper, we first demonstrate the importance of an accurate age measurement, as expected from Plato, in constraining the planetary properties. Well-determined stellar ages can reduce the bulk-metallicity uncertainty up to about a factor of two. We next infer the bulk metallicity of warm giants from the Ariel mission reference sample and identify the Ariel high-priority targets for which a measured atmospheric metallicity can clearly break the degeneracy in the inferred composition. We show that knowledge of the atmospheric metallicity can broadly reduce the bulk-metallicity uncertainty by a factor of four to eight. We conclude that the accurate age determination from Plato and atmospheric measurements by Ariel and the James Webb Space Telescope will play a key role in revealing the composition of giant exoplanets. arXiv: http://arxiv.org/abs/http://arxiv.org/abs/2211.05468v2

Towards a new era in giant exoplanet characterisation by Simon Müller et al. on Wednesday 23 November Determining the composition of giant exoplanets is crucial for understanding their origin and evolution. However, the planetary bulk composition is not measured directly but must be deduced from a combination of mass-radius measurements, knowledge of the planetary age and evolution simulations. Accurate determinations of stellar ages, mass-radius, and atmospheric compositions from upcoming missions can significantly improve the determination of the heavy-element mass in giant planets. In this paper, we first demonstrate the importance of an accurate age measurement, as expected from Plato, in constraining the planetary properties. Well-determined stellar ages can reduce the bulk-metallicity uncertainty up to about a factor of two. We next infer the bulk metallicity of warm giants from the Ariel mission reference sample and identify the Ariel high-priority targets for which a measured atmospheric metallicity can clearly break the degeneracy in the inferred composition. We show that knowledge of the atmospheric metallicity can broadly reduce the bulk-metallicity uncertainty by a factor of four to eight. We conclude that the accurate age determination from Plato and atmospheric measurements by Ariel and the James Webb Space Telescope will play a key role in revealing the composition of giant exoplanets. arXiv: http://arxiv.org/abs/http://arxiv.org/abs/2211.05468v2

3D Detection and Characterisation of ALMA Sources through Deep Learning by Michele Delli Veneri et al. on Tuesday 22 November We present a Deep-Learning (DL) pipeline developed for the detection and characterization of astronomical sources within simulated Atacama Large Millimeter/submillimeter Array (ALMA) data cubes. The pipeline is composed of six DL models: a Convolutional Autoencoder for source detection within the spatial domain of the integrated data cubes, a Recurrent Neural Network (RNN) for denoising and peak detection within the frequency domain, and four Residual Neural Networks (ResNets) for source characterization. The combination of spatial and frequency information improves completeness while decreasing spurious signal detection. To train and test the pipeline, we developed a simulation algorithm able to generate realistic ALMA observations, i.e. both sky model and dirty cubes. The algorithm simulates always a central source surrounded by fainter ones scattered within the cube. Some sources were spatially superimposed in order to test the pipeline deblending capabilities. The detection performances of the pipeline were compared to those of other methods and significant improvements in performances were achieved. Source morphologies are detected with subpixel accuracies obtaining mean residual errors of $10^{-3}$ pixel ($0.1$ mas) and $10^{-1}$ mJy/beam on positions and flux estimations, respectively. Projection angles and flux densities are also recovered within $10%$ of the true values for $80%$ and $73%$ of all sources in the test set, respectively. While our pipeline is fine-tuned for ALMA data, the technique is applicable to other interferometric observatories, as SKA, LOFAR, VLBI, and VLTI. arXiv: http://arxiv.org/abs/http://arxiv.org/abs/2211.11462v1

3D Detection and Characterisation of ALMA Sources through Deep Learning by Michele Delli Veneri et al. on Monday 21 November We present a Deep-Learning (DL) pipeline developed for the detection and characterization of astronomical sources within simulated Atacama Large Millimeter/submillimeter Array (ALMA) data cubes. The pipeline is composed of six DL models: a Convolutional Autoencoder for source detection within the spatial domain of the integrated data cubes, a Recurrent Neural Network (RNN) for denoising and peak detection within the frequency domain, and four Residual Neural Networks (ResNets) for source characterization. The combination of spatial and frequency information improves completeness while decreasing spurious signal detection. To train and test the pipeline, we developed a simulation algorithm able to generate realistic ALMA observations, i.e. both sky model and dirty cubes. The algorithm simulates always a central source surrounded by fainter ones scattered within the cube. Some sources were spatially superimposed in order to test the pipeline deblending capabilities. The detection performances of the pipeline were compared to those of other methods and significant improvements in performances were achieved. Source morphologies are detected with subpixel accuracies obtaining mean residual errors of $10^{-3}$ pixel ($0.1$ mas) and $10^{-1}$ mJy/beam on positions and flux estimations, respectively. Projection angles and flux densities are also recovered within $10%$ of the true values for $80%$ and $73%$ of all sources in the test set, respectively. While our pipeline is fine-tuned for ALMA data, the technique is applicable to other interferometric observatories, as SKA, LOFAR, VLBI, and VLTI. arXiv: http://arxiv.org/abs/http://arxiv.org/abs/2211.11462v1

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.18.517140v1?rss=1 Authors: Panthi, S., Chapman, P., Szyszka, P., Beck, C. W. Abstract: Epilepsy, a clinical diagnosis characterized by paroxysmal episodes known as seizures, affects 1% of people worldwide. An estimated 30% of patients continue to have seizures even on medication, and adverse effects are common. Safe and patient-specific treatment is vital and can be achieved by the development of rapid pre-clinical models of for identified epilepsy genes. Epilepsy can result from either brain injury or gene mutations, and can also be induced chemically. Xenopus laevis tadpoles could be a useful model for confirmation of variants of unknown significance found in epilepsy patients, and for drug re-purposing screens that could eventually lead to benefits for patients. Here, we characterise and quantify seizure-related behaviours in X. laevis tadpoles arrayed in 24-well plates. To provoke acute seizure behaviours, tadpoles were chemically induced with either pentylenetetrazole (PTZ) or 4-aminopyridine (4-AP). To test the capacity to adapt this method for drug testing, we also exposed induced tadpoles to the anti-seizure drug valproate (VPA). Four induced seizure-like behaviours were described and manually quantified, and two of these (darting, circling) could be accurately detected automatically, using the video analysis software TopScan. Additionally, we recorded swimming trajectories and mean swimming velocity. Automatic detection showed that either PTZ or 4-AP induced darting behaviour and increased mean swimming velocity compared to untreated controls. Both parameters were significantly reduced in the presence of VPA. In particular, darting behaviour was a shown to be a sensitive measure of epileptic seizure activity. While we could not automatically detect the full range of seizure behaviours, this method shows promise for future studies, since X. laevis is a well-characterised and genetically tractable model organism. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

The Chronicles of Riddick, when it first released in 2004, was the definition of mediocre sci-fi schlock.  Riddick, played by Vin Diesel, came across as a generic edgelord, and it seemed to lean into special effects and spectacle over anything more substantial.  It's a direction that didn't play well with critics, nor with the fans of the previous entry, Pitch Black. So it was to everyone's surprise when a videogame set in this same world was released to widespread critical acclaim.  Vin Diesel, under his macho exterior, was secretly a bit of a geek, and was heavily involved in the development.  Critics praised just about every aspect of this short and tightly-made prison-escape, from the visuals, to the stealth, to the characterisation.But were those critics simply wowed by the glossiness of a cinematic FPS?  Are the individual gameplay mechanics in Riddick actually fun in their own right?  Or is this just another mid-2000's hybrid FPS game that is better off forgotten?On this episode, we discuss:Structure. To this day, Escape from Butcher Bay's non-conventional structure continues to impress modern audiences. Did it impress us? Stealth, shooting and investigation. Individually, these are sub-par. So what's Riddick's secret that brings these together into something special. Characterisation. Is Vin Diesel's beloved character simply a generic action hero, or is there more to him than meets the eye? As a prequel, does Butcher Bay limit Riddick's potential for development? Or does it set up Pitch Black's captivating final moments.We answer all these questions and more on the 97th episode of the Retro Spectives Podcast!—Intro Music: KieLoBot - Tanzen KOutro Music: Rockit Maxx - One point to anotherRiddick OST: Gustaf Grefburg—Is it worth watching the third Riddick movie, or is it just more of the same?  Are there any other obvious influences we forgot to mention outside of repeatedly calling out Half Life?  Is Dark Athena as bad as the reviews suggest?  Come let us know what you think on our community discord server!

How to write great characters. Today's guest is a highly acclaimed author of over thirty books for children, across all styles and ages. Her work is published internationally to many commendations and awards. She has also worked as a publisher at Penguin Books in a career that has just been incredible. Today, she's popped in to share her latest book. A real thriller, set in forest late at night. As well as to share her author journey, tips and tricks. Everybody, please welcome Jane Godwin.

Seismic noise characterisation at Gingin high optical gravitational wave test facility by Hamid Satari et al. on Tuesday 11 October A critical consideration in the design of next generation gravitational wave detectors is isolation from seismic vibrations that introduces various coherent and incoherent noises to the interferometers at different frequencies. We present the results of a detailed low frequency ambient seismic noise characterization (0.1--10~Hz) at Gingin High Optical Power Facility in Western Australia using a seismic array. The dominant noise sources below 1~Hz is microseism (0.06--1~Hz), strongly correlated with swell and sea heights measured by nearby buoy stations. Above 1~Hz, the seismic spectrum is dominated by wind induced seismic noise with a diurnal variation that prevents characterizing the background anthropogenic noise sources based on their daily power variations. We use f-k beamforming to distinguish between coherent and incoherent wind induced seismic noise. This allows the separation of some anthropogenic noise from wind induced noise based on the temporal variation of spatio-spectral properties. We show that the seismic coherency is reduced by wind induced seismic noise for wind speeds above 6~m/s. Furthermore, there are several spectral peaks between 4--9~Hz associated with the interaction of wind with a 40~m tall tower among which one at 4.2~Hz is strongest and coherent. By comparing our results with the properties of seismic noise at Virgo, we demonstrate that while the secondary microseism noise level is two orders of magnitude higher in Gingin (0.2~Hz), the anthropogenic noise level is three orders of magnitude lower between 2 and 4~Hz due to the absence of nearby road traffic. It is also at least one order of magnitude lower between 4 and 10~Hz due to the sparse population in Gingin. arXiv: http://arxiv.org/abs/http://arxiv.org/abs/2209.06559v2

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.26.509462v1?rss=1 Authors: Grant-Peters, M., Rich-Griffin, C., Yeung, H.-Y., Thomas, T., Davis, S., Azizian, M., Fisher, J., Fischer, R., Cinque, G. A., Dendrou, C. A. Abstract: Progressive multiple sclerosis (MS) is driven by demyelination, neuroaxonal loss, and mitochondrial damage occurring behind a closed blood-brain barrier (BBB). Patients with progressive MS typically fail to respond to available immunomodulatory drugs that reduce relapses in early disease. This indicates a dire need to identify non-canonical therapeutic avenues to limit neurodegeneration and promote protection and repair. Here, we have employed high-resolution multiomic profiling to characterise the biochemical and metabolic adaptations underpinning MS pathology, as these have been incompletely described but critically, may be amenable to BBB-permeable drug targeting. Using synchrotron radiation (SR)- and focal plane array (FPA)-based Fourier transform infrared microspectroscopy (FTIR), we spatially mapped the biochemical features present in human progressive MS and control post-mortem brain and rare spinal cord tissue. By employing single-nuclear RNA sequencing (snRNA-seq), 10x Genomics Visium spatial transcriptomics and spatial proteomics to resolve their cellular context, we found that these biochemical features provide a uniquely and highly disease-specific barcode for distinct pathological niches within the tissue. Characterisation of the metabolic processes underpinning these niches revealed an associated re-organisation of the astrocytic landscape in the grey and white matter, with implications for the treatment of progressive MS. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

Hyper-runaway and hypervelocity white dwarf candidates in Gaia Data Release 3: possible remnants from Ia Iax supernova explosions or dynamical encounters by Andrei P. Igoshev et al. on Wednesday 21 September Type Ia and other peculiar supernovae (SNe) are thought to originate from the thermonuclear explosions of white dwarfs (WDs). Some of the proposed channels involve the ejection of a partly exploded WD (e.g. Iax SN remnant) or the companion of an exploding WD at extremely high velocities (>400 km s$^{-1}$). Characterisation of such hyper-runaway/hypervelocity (HVS) WDs might therefore shed light on the physics and origins of SNe. Here we analyse the Gaia DR3 data to search for HVS WDs candidates, and peculiar sub-main-sequence (sub-MS) objects. We retrieve previously identified HVS, and find tens of new HVS candidates. We identify two new unbound WD HVS, 14 new likely-unbound sub-MS objects, and a handful of WDs and sub-MS objects with velocities comparable to the Galactic escape velocity (based only on tangential velocities). We find tens of additional likely bound hyper-runaway WDs (v$>400$ km s$^{-1}$). The numbers and properties of the HVS WD and sub-MS candidates suggest that extreme velocity ejections ($>1000$ km s$^{-1}$) can accompany at most a small fraction of type Ia SNe, disfavouring a significant contribution of the D6-scenario to the origin of Ia SNe. The rate of HVS ejections following the hybrid WD reverse-detonation channel could be consistent with the identified HVSs. The numbers of lower-velocity HVS WDs could be consistent with type Iax SNe origin and/or contribution from dynamical encounters. We also searched for HVS WDs related to known SN remnants, but identified only one such candidate. arXiv: http://arxiv.org/abs/http://arxiv.org/abs/2209.09915v1

GJ 3090 b: one of the most favourable mini-Neptune for atmospheric characterisation by J. M. Almenara et al. on Monday 19 September We report the detection of GJ 3090 b (TOI-177.01), a mini-Neptune on a 2.9-day orbit transiting a bright (K = 7.3 mag) M2 dwarf located at 22 pc. The planet was identified by the Transiting Exoplanet Survey Satellite and was confirmed with the High Accuracy Radial velocity Planet Searcher radial velocities. Seeing-limited photometry and speckle imaging rule out nearby eclipsing binaries. Additional transits were observed with the LCOGT, Spitzer, and ExTrA telescopes. We characterise the star to have a mass of 0.519 $pm$ 0.013 M$_odot$ and a radius of 0.516 $pm$ 0.016 R$_odot$. We modelled the transit light curves and radial velocity measurements and obtained a planetary mass of 3.34 $pm$ 0.72 M$_oplus$, a radius of 2.13 $pm$ 0.11 R$_oplus$, and a mean density of 1.89$^{+0.52}_{-0.45}$ g/cm$^3$. The low density of the planet implies the presence of volatiles, and its radius and insolation place it immediately above the radius valley at the lower end of the mini-Neptune cluster. A coupled atmospheric and dynamical evolution analysis of the planet is inconsistent with a pure H-He atmosphere and favours a heavy mean molecular weight atmosphere. The transmission spectroscopy metric of 221$^{+66}_{-46}$ means that GJ 3090 b is the second or third most favourable mini-Neptune after GJ 1214 b whose atmosphere may be characterised. At almost half the mass of GJ 1214 b, GJ 3090 b is an excellent probe of the edge of the transition between super-Earths and mini-Neptunes. We identify an additional signal in the radial velocity data that we attribute to a planet candidate with an orbital period of 13 days and a mass of 17.1$^{+8.9}_{-3.2}$ M$_oplus$, whose transits are not detected. arXiv: http://arxiv.org/abs/http://arxiv.org/abs/2207.14121v2

GJ 3090 b: one of the most favourable mini-Neptune for atmospheric characterisation by J. M. Almenara et al. on Monday 19 September We report the detection of GJ 3090 b (TOI-177.01), a mini-Neptune on a 2.9-day orbit transiting a bright (K = 7.3 mag) M2 dwarf located at 22 pc. The planet was identified by the Transiting Exoplanet Survey Satellite and was confirmed with the High Accuracy Radial velocity Planet Searcher radial velocities. Seeing-limited photometry and speckle imaging rule out nearby eclipsing binaries. Additional transits were observed with the LCOGT, Spitzer, and ExTrA telescopes. We characterise the star to have a mass of 0.519 $pm$ 0.013 M$_odot$ and a radius of 0.516 $pm$ 0.016 R$_odot$. We modelled the transit light curves and radial velocity measurements and obtained a planetary mass of 3.34 $pm$ 0.72 M$_oplus$, a radius of 2.13 $pm$ 0.11 R$_oplus$, and a mean density of 1.89$^{+0.52}_{-0.45}$ g/cm$^3$. The low density of the planet implies the presence of volatiles, and its radius and insolation place it immediately above the radius valley at the lower end of the mini-Neptune cluster. A coupled atmospheric and dynamical evolution analysis of the planet is inconsistent with a pure H-He atmosphere and favours a heavy mean molecular weight atmosphere. The transmission spectroscopy metric of 221$^{+66}_{-46}$ means that GJ 3090 b is the second or third most favourable mini-Neptune after GJ 1214 b whose atmosphere may be characterised. At almost half the mass of GJ 1214 b, GJ 3090 b is an excellent probe of the edge of the transition between super-Earths and mini-Neptunes. We identify an additional signal in the radial velocity data that we attribute to a planet candidate with an orbital period of 13 days and a mass of 17.1$^{+8.9}_{-3.2}$ M$_oplus$, whose transits are not detected. arXiv: http://arxiv.org/abs/http://arxiv.org/abs/2207.14121v2

Seismic noise characterisation at Gingin high optical gravitational wave test facility by Hamid Satari et al. on Wednesday 14 September A critical consideration in the design of next generation gravitational wave detectors is isolation from seismic vibrations that introduces various coherent and incoherent noises to the interferometers at different frequencies. We present the results of a detailed low frequency ambient seismic noise characterization (0.1--10~Hz) at Gingin High Optical Power Facility in Western Australia using a seismic array. The dominant noise sources below 1~Hz is microseism (0.06--1~Hz), strongly correlated with swell and sea heights measured by nearby buoy stations. Above 1~Hz, the seismic spectrum is dominated by wind induced seismic noise with a diurnal variation that prevents characterizing the background anthropogenic noise sources based on their daily power variations. We use f-k beamforming to distinguish between coherent and incoherent wind induced seismic noise. This allows the separation of some anthropogenic noise from wind induced noise based on the temporal variation of spatio-spectral properties. We show that the seismic coherency is reduced by wind induced seismic noise for wind speeds above 6~m/s. Furthermore, there are several spectral peaks between 4--9~Hz associated with the interaction of wind with a 40~m tall tower among which one at 4.2~Hz is strongest and coherent. By comparing our results with the properties of seismic noise at Virgo, we demonstrate that while the secondary microseism noise level is two orders of magnitude higher in Gingin (0.2~Hz), the anthropogenic noise level is three orders of magnitude lower between 2 and 4~Hz due to the absence of nearby road traffic. It is also at least one order of magnitude lower between 4 and 10~Hz due to the sparse population in Gingin. arXiv: http://arxiv.org/abs/http://arxiv.org/abs/2209.06559v1

Photometric and dynamic characterisation of active asteroid 248370 2005 QN173 by Bojan Novakovic et al. on Sunday 04 September We present the physical and dynamical properties of the recently discovered active asteroid (248370) 2005 QN173 (aka 433P). From our observations, we derived two possible rotation period solutions of 2.7 and 4.1 hours. The corresponding light curve amplitudes computed after correcting for the effect of coma are 0.28 and 0.58 mag, respectively. Both period solutions are shorter than the critical rotation limit computed for a strengthless triaxial ellipsoid, suggesting that rotation mass shedding should at least partly be responsible for the observed activity. We confirm that the activity level is fading further, but at a very modest rate of only 0.006 mag/day, still also compatible with sublimation-driven activity. We found that 248370 likely belongs to the Themis asteroid family, making it a fourth main-belt comet associated with this group. Orbital characteristics of 248370 are also consistent with its origin in the young 288P cluster of asteroids. The 288P cluster is associated with its namesake main-belt comet, providing an exciting possibility for a comparative analysis of intriguing main-belt comets 248370 and 288P. arXiv: http://arxiv.org/abs/http://arxiv.org/abs/2209.00971v1

To improve space traffic management and mitigate the collisional orbital risk, we propose to combine optical observations with passive radio frequency measurements to increase the determination accuracy of orbiting satellites.

Characterization, in conflict of laws, is the second stage of the procedure to resolve a lawsuit that involves foreign law. The process is described in English law as Characterisation, or classification within the English judgments of the European Court of Justice. It is alternatively known as qualification in French law. It is used to determine the correct choice of law rules based on the circumstances of the case, primarily relating to matters of property. This is to reconcile differences between laws of different legal jurisdictions. The objective of characterization is to determine the nature of the action brought by the defendant in order to determine what relevant rules of applicable law apply. This may result in applying laws which differ from the lex fori. Additional factors make this determination not necessarily a simple process as the incidental question and renvoi can make determining the initial point of reference difficult. The leading authority in England and Wales is Macmillan Inc v Bishopsgate Investment Trust plc (number 3) . Overview. Characterization is one of the key elements in demarcating the choice of law and jurisdiction issues. The first stage is for the court to determine if it has jurisdiction, if appropriate, to avoid forum shopping. Once the forum court decides that it has jurisdiction to hear the case, it must characterize or classify the causes of action, this relates to choice of law matters. That is regarded as the most important and difficult problem in conflict of laws as trade and travel between states has become the norm. The effects of broken promises, defective goods, traffic accidents and marital squabbles are no longer confined to the sovereign territory of one particular state or nation. This is especially complicated because domestic laws usually operate to satisfy domestic interest. Various causes in actions and their respective remedies differ depending on the state. This derives from historical and political circumstances. The addition of the Rome 1 and Rome 2 Regulations to the European Union conflict of laws regime is designed to determine the choice of law which applies to situations where commercial or civil matters of broken promises, defective goods, traffic accidents, etcetera. with a party which is domiciled in a Member State. The role of characterization within an international private law adjudication might be highlighted if understood within the simplest example of the sale of a bicycle by A to B. The transaction has both contractual and proprietary elements. Different jurisdictions will characterize the matter in different ways depending on their own laws. As is crucial within the international private law context, it is the responsibility of the adjudicating court to determine the proper law and subsequently apply it. --- Send in a voice message: https://anchor.fm/law-school/message Support this podcast: https://anchor.fm/law-school/support

Welcome to In Suspense - a podcast and vodcast for fans and writers of crime fiction. Here is our fourth minisode on the editing process with author and editorial director Phoebe Morgan. Today we're chatting about the characterisation. Phoebe Morgan is a bestselling author and award-winning editor. You can follow her on Twitter @Phoebe_A_Morgan, Instagram @phoebeannmorgan, Facebook @PhoebeMorganAuthor or find her blog about publishing and writing at www.phoebemorganauthor.com. You can find links to Phoebe's amazing books here: Bookshop.org - https://bit.ly/3McLNLCAmazon.co.uk - https://amzn.to/3rCvtfk

Summary of the article titled Smartness that matters: Towards a comprehensive and human-centred characterisation of smart cities from 2016 by Alexander Prado Lara, Eduardo Moreira Da Costa, Thiago Zilinscki Furlani, and Tan Yigitcanlar, published in the Journal of Open Innovation: Technology, Market and Complexity. Since we are investigating the future of cities, I thought it would be interesting to see a collection of smart city definitions and their deficiencies. This article investigates previous smart city definitions and proposes a new, human-centred characterisation for them. You can find the article through this link. Abstract: The term ‘smart cities' is a widely used, but at the same time a highly fuzzy concept. The fuzziness hinders our understanding on the benefits of its adoption, and explains the existence of many relevant activities with fragmented or distorted views of what a truly smart city is. The aim of this paper is to undertake a comprehensive review of how smart cities are perceived in the literature and in the light of the findings propose a clearer definition. Overview of the key terms, concepts and definitions associated to smart cities, reported in this paper, demonstrates that the definitions found in the academic literature have limited scope, and are overly focused on strategic drivers and specific actions, instead of making explicitly the connection between the concept of smart cities and the creation of environments that promote happiness and wellbeing of their residents—which should be the main function of a city. Following the thorough review on the smart cities literature, the paper proposes a comprehensive, human-centred, and context-free definition for smart cities. This definition brings an endogenous view on smart cities in which the central element is the direct participation of local actors and stakeholders in the process of thinking, defining, planning, and executing social, technological and urban transformations in cities. You can find the transcript through this link. What wast the most interesting part for you? What questions did arise for you? Let me know on twitter @WTF4Cities! I hope this was an interesting episode for you and thanks for tuning in. Music by Lesfm from Pixabay

HORIZON FORBIDDEN WEST is the blockbuster sequel the 2016 title HORIZON ZERO DAWN, a third person action game with wonderfully designed elements that keep you hooked. An early contender for one of the most beautiful games ever produced this game takes the open world exploration and combat of the first game, and fills in the gaps to make a believable human world. John Rogers of Gaming in the Wild joins Mainstream to share stories of this hard scifi world and the 4GB of captures taken in this stunning visual feast. SIFTER is produced by Nicholas Kennedy, Kyle Pauletto, Fiona Bartholomaeus, Daniel Ang & Adam Christou. Mitch Loh is Senior Producer and Gianni Di Giovanni is our Executive Producer. Join the SIFTER Discord Support SIFTER by buying our Australian made T-Shirts Support the show: https://sifter.store See omnystudio.com/listener for privacy information.

Today on the show I am talking about developing historical characters that ring true for their time and how their environment can be used to help shape characters who are believable, interesting, and of their time. 

This week I am talking to award winning author, Marni Graff about writing characters that endure and continue to be believable throughout a series. 

Today I am talking about developing believable historical characters. have you ever wondered how you can get inside the mind of someone from another era? Today's show is full of actionable tips that will get you started. 

Joe Abercrombie writes some of the most realistic, fleshed-out, and interesting characters in modern fantasy. Today, I'll analyse what makes his characters so complex.  Twitter: @JedHerne Email: jed.herne1@gmail.com Shownotes (links to books I mentioned, etc.): novelanalyst.com/episode2 Join my VIP email list: novelanalyst.com/email--- Send in a voice message: https://anchor.fm/novelanalyst/message Hosted on Acast. See acast.com/privacy for more information.