Podcasts about host disease

Dr. Brandon K.K. Fields speaks with Dr. Jennifer Holter-Chakrabarty about her groundbreaking research on fluorine-18 fluorothymidine (FLT) PET in the imaging of gastrointestinal graft-versus-host disease (GVHD) after allogeneic stem cell transplantation. Together, they explore a potential future role for FLT-PET in detection of early and/or subclinical GVHD, which may serve to guide future treatment strategies for transplant patients in years to come. 18F-FLT PET and Blood-based Biomarkers for IdentifyingGastrointestinal Graft versus Host Disease after Allogeneic CellTransplantation. Holter-Chakrabarty and McNally et al. Radiology: Imaging Cancer 2025; 7(1):e240096. 

Welcome to the third episode of ASTCT Talks' exclusive 8-part series, supported by an educational grant from Sanofi US. In this series, ASTCT President Dr. Corey Cutler sits down with authors from the latest Graft-versus-Host Disease and Late Effects Following Allogeneic Transplantation journal collection to discuss their research and its implications for patient care.In this episode, Dr. Cutler is joined by Dr. Steven Z. Pavletic, the GVHD and Late Effects Section and Myeloid Malignancies Program Director at the NIH in Bethesda, Maryland. Widely recognized as a titan in chronic GVHD research, Dr. Pavletic explores an emerging yet often overlooked area in transplantation medicine—lifestyle medicine.Together, they discuss the role of lifestyle interventions, including nutrition, exercise, sleep, and stress management, in improving long-term outcomes for patients with chronic GVHD. Dr. Pavletic highlights the growing body of evidence supporting these approaches and the urgent need for more research and clinical guidelines to help providers counsel patients effectively.Tune in for an eye-opening conversation on how small, practical changes can make a significant impact on quality of life and post-transplant recovery. To dive deeper into this topic, read Dr. Pavletic's full article here.

A stem cell transplant for blood cancer is just the beginning – what may come next for the patient can… The post Beyond the Transplant: Navigating Graft-vs-Host Disease (GVHD) first appeared on The Bloodline with LLS.

Host: Charles Turck, PharmD, BCPS, BCCCP Guest: Miguel-Angel Perales, MD Guest: Anna Sureda, MD, PhD Unfortunately, the treatment paradigm for acute graft-versus-host disease (aGVHD) has not changed for a couple of decades as steroids remain the first-line treatment.1 However, steroids are not a targeted therapy, and they have many side effects that are not well tolerated by patients, including life-threatening infections.1-3 Given these risks, it is important to know how to manage infections related to immunosuppression and optimize the care of patients with aGVHD. Joining Dr Charles Turck to discuss the current landscape of aGVHD management are Dr Miguel-Angel Perales and Dr Anna Sureda. Dr Miguel-Angel Perales is the Chief of the Adult Bone Marrow Transplantation Service at Memorial Sloan Kettering Cancer Center in New York, and Dr Sureda is the Head of Clinical Hematology at the University of Barcelona in Spain. References: Bell EJ, Yu J, Bhatt V, et al. Healthcare resource utilization and costs of steroid-associated complications in patients with graft-versus-host disease. Transplant Cell Ther. 2022;28(10):707.e1-707.e7. doi:10.1016/j.jtct.2022.04.014 Sullivan PW, Ghushchyan VH, Globe G, Sucher B. Health-related quality of life associated with systemic steroids. Qual Life Res. 2017;26(4):1037-1058. García-Cadenas I, Rivera I, Martino R, et al. Patterns of infection and infection-related mortality in patients with steroid-refractory acute graft versus host disease. Bone Marrow …

Listen to a soundcast of the 12.18.2024 FDA approval of Ryoncil (remestemcel-L-rknd) for steroid-refractory acute graft versus host disease in pediatric patients.

Welcome to the second installment of an exclusive 8-part ASTCT Talks series, supported by an educational grant from Sanofi US. In this series, ASTCT President Dr. Corey Cutler speaks with authors from each article in the latest Graft versus Host Disease and Late Effects Following Allogeneic Transplantation Journal collection. In this episode, Dr. Cutler is joined by Dr. Nathaniel S. Treister, a recognized expert in oral medicine, to discuss the intricacies of oral chronic GVHD and its impact on oral health following allogeneic hematopoietic cell transplantation. They explore the diagnostic criteria, effective management strategies, and long-term care considerations for patients, highlighting the importance of both supportive care and multidisciplinary collaboration. For further insights, read Dr. Treister's article, “Oral Chronic Graft-versus-Host Disease and Oral Health after Allogeneic Hematopoietic Cell Transplantation — What the Care Team Needs to Know”, and stay tuned as Dr. Cutler and authors continue to provide a comprehensive guide on cGVHD management through this supplement series.

Welcome to the first installment of an exclusive 8-part ASTCT Talks series, supported by an educational grant from Sanofi US. In this series, ASTCT President Dr. Corey Cutler speaks with authors from each article in the latest ASTCT Journal of Transplantation and Cellular Therapy GVHD supplement. In this opening episode, Dr. Cutler is joined by Dr. Katie Luo, a leading ophthalmologist, to discuss the complexities of ocular GVHD, why it goes beyond “just dry eye,” and how an integrated, multidisciplinary approach can offer better patient outcomes. For further insights, read Dr. Luo's full article, “Understanding Ocular Graft-versus-Host Disease to Facilitate an Integrated Multidisciplinary Approach”, and stay tuned as Dr. Cutler delves into each article with its author, providing a comprehensive guide on GVHD management through this entire supplement series.

Graft vs Host Disease, known as GvHD, is a side effect of a life-saving procedure. People who undergo an allogeneic stem cell transplant - where a donor's stem cells are transplanted into the recipient - can experience either acute or chronic GvHD. Listen to blood cancer survivor Libby Goszer who shares her coping strategies for living with chronic GvHD, a condition she describes as "a continual rollercoaster ride that has both expected and unexpected twists and turns." The B.C. resident has lived with cGvHD for 16 years; she's learned to enjoy the 'ride' of her life as a mom, wife, professional, and volunteer. Also in this episode, a Canadian hematologist-oncologist and a specialist in GvHD, Dr. Kirk Schultz talks about chronic as well as acute GvHD, symptoms, and advances in medical treatments. Read more about GvHD from The Leukemia & Lymphoma Society of Canada (LLSC) with these easy-to-understand, short factsheets: Understanding GvHD - https://www.bloodcancers.ca/sites/default/files/2024-10/lls1768-f-fs-gvhd-understand-e03.pdf Treating GvHD - https://www.bloodcancers.ca/sites/default/files/2024-10/lls1769-c-fs-gvhd-treating-e02.pdf If you have any questions about your blood cancer experience, or that of a loved one, please reach out for personalized support from a trained LLSC community worker in your region. Find their contact information at: https://www.bloodcancers.ca/i-have-blood-cancer/how-we-can-help/access-one-one-personalized-support You are not alone.

In this episode of the Oncology Brothers Podcast, hosts Drs. Rohit and Rahul Gosain welcome Dr. Shernan Holtan from Roswell Park Comprehensive Cancer Center to discuss the recent approval of Axatilimab, a novel monoclonal antibody for the treatment of chronic graft-versus-host disease (GVHD). Join us as we explore the differences between acute and chronic GVHD, the challenges faced by community oncologists in managing this condition, and the exciting results from the AGAVE-201 study that led to Axatilimab's FDA approval. Dr. Holtan shares insights on the drug's mechanism of action, its dosing regimen, and the importance of patient-reported outcomes in assessing treatment efficacy. We also delve into the safety profile of Axatilimab, discussing potential side effects, infusion reactions, and the significance of partnering with tertiary care centers for optimal patient management. Whether you're a healthcare professional or simply interested in the latest advancements in oncology, this episode provides valuable information on managing chronic GVHD and improving patient quality of life. Don't forget to like, subscribe, and check out our other episodes for more discussions on recent approvals and the current standard of care for various malignancies! #OncologyBrothers #GVHD #Axatilimab #ChronicGVHD #CancerCare #Podcast   Website: http://www.oncbrothers.com/ X/Twitter: https://twitter.com/oncbrothers Contact us at info@oncbrothers.com

Dr. Doris Ponce from Memorial Sloan Kettering Cancer Center delves into atypical presentations of chronic graft-versus-host disease (cGVHD). As an associate member, co-chair of the Center for Hematologic Malignancies, and director of the Graft-Versus-Host Disease Program, Dr. Ponce provides an in-depth understanding of this complex condition.Dr. Ponce emphasizes the diverse symptoms of GVHD that often overlap with other conditions, making diagnosis challenging. She outlines the eight organs typically affected by GVHD: skin, mouth, eyes, musculoskeletal, genitourinary, lungs, liver, and gastrointestinal tract. However, she highlights that GVHD can also present atypically in organs such as the kidneys, nervous system, muscles, heart, and pancreas, causing symptoms such as serositis, effusions, nephrotic syndrome, and autoimmune disorders like vitiligo.Atypical presentations of GVHD are rare and require exclusion of other conditions such as drug side effects or infections before diagnosis. Dr. Ponce stresses the importance of patients communicating any new or unusual symptoms with their clinicians, as these might not initially seem connected to GVHD.Focusing on skin-related GVHD, Dr. Ponce describes common and atypical manifestations, including tight skin (sclerodermatous changes), pigmentation loss, dryness, and psoriasis-like appearances. Treatment varies but often involves topical steroids or immune suppression tailored to individual symptoms. For daily skincare, she advises avoiding frequent hot showers, using lukewarm water, and selecting gentle, fragrance-free products to prevent skin irritation.Regarding sun exposure, Dr. Ponce recommends using broad-spectrum sunscreen with SPF 30 or higher, and wearing protective clothing to prevent rashes exacerbated by sunlight. She also discusses the use of chemical and mineral sunscreens, noting that mineral sunscreens, despite being thicker, are better suited for sensitive skin.Peggy and Dr. Ponce discuss the Long Good Feel Better program that the American Cancer Society provides. For patients wanting to wear makeup, Dr. Ponce suggests choosing products designed for sensitive skin, avoiding those with harsh ingredients or multiple components, and replacing makeup regularly to prevent contamination. She also warns against using organic or preservative-free makeup due to infection risks.Haircare after GVHD often involves managing hair loss and changes in texture. Dr. Ponce advises infrequent washing, using gentle products, and considering supplements like biotin. For wigs, she cautions against those requiring glue and suggests alternatives like clip-on wigs or scarves. Hair dyeing is permissible with ammonia-free products.Nail care post-transplant includes using nail hardeners and avoiding acrylic nails. Dr. Ponce also emphasizes checking for underlying issues like vitamin deficiencies that may affect nail health.In closing, Dr. Ponce highlights the holistic approach to patient care at Memorial Sloan Kettering Cancer Center, addressing both medical and psychological aspects to support patients' overall well-being. She encourages patients to communicate any concerns, as seemingly minor symptoms might significantly impact their health and recovery. Dr. Ponce's dedication to improving patients' lives extends beyond treating their conditions, fostering confidence and quality of life throughout their recovery journey.More:Memorial Sloan Kettering Cancer Center's Tips for Managing GVHD (created by Dr. Ponce and dermatologist) Dr. Alina Markova:https://www.mskcc.org/cancer-care/patient-education/tips-managing-graft-versus-host-disease-gvhdAmerican Cancer Society's Look Good Feel Better Program: https://lookgoodfeelbetter.org/Memorial Sloan Kettering Cancer Center Website: https://www.mskcc.org/Sally Hansen Nail Hardener: https://www.sallyhansen.com/en-us/nail-care/nail-care/mega-strength-hardenerSurvivor recommended clothing brands that have SPF/UPF clothing:Coolibar: https://www.coolibar.com/Columbia: https://www.columbia.com/c/sun-protection/Baleaf: https://www.baleaf.com/collections/upf50This season is made possible thanks to donations from Syndax and Incyte.https://syndax.com/https://incyte.com/ Follow the nbmtLINK on Instagram! https://www.instagram.com/nbmtlink/

In this episode, we speak with Brigham and Women's Hospital and Dana Farber Cancer Institute's Dr. Hermioni "Hermi" Amonoo, an esteemed psychiatrist, psychosocial oncologist, and associate professor at Harvard Medical School. Our discussion centers on the psychological distress associated with graft versus host disease (GVHD) following a bone marrow stem cell transplant. Dr. Amonoo sheds light on the significant psychological challenges patients with GVHD face, noting that approximately 50% experience clinically significant depression, and about a third suffer from anxiety. This psychological distress permeates various aspects of daily life, affecting routines, relationships, and social roles.Dr. Amonoo uses a powerful analogy to describe psychological well-being, likening it to a toolbox filled with various tools and equipment essential for managing distress. Key components of this toolbox include psychotherapeutic interventions, health behaviors such as good nutrition and physical activity, medication when necessary, and professional help from specialty mental health clinicians. Social support and meaningful relationships also play a crucial role in enhancing wellbeing. Peer support, for instance, can offer valuable lived experiences and tips for thriving despite the challenges posed by GVHD.We also delve into the importance of the clinical team in managing cGVHD. The clinical team helps patients understand the disease, manage symptoms, and connect with resources. Dr. Amonoo emphasizes the importance of patients communicating openly with their clinical team, urging them not to hesitate in asking questions or expressing concerns about new symptoms.Pacing oneself is another critical aspect discussed. GVHD is not a static condition, and symptoms can evolve over time. Patients should give themselves grace, avoid overexertion, and maintain a sustainable pace to manage their energy levels effectively. Dr. Amonoo compares this to running a marathon, where pacing is essential to avoid burnout.Caregivers, who play a vital role in the patient's journey, must also prioritize their own well being. Dr. Amonoo stresses that caregiver well being directly impacts patient well being, encouraging caregivers to practice self-care and seek help when needed. Communication between caregivers and patients is crucial, especially as relationships and priorities may evolve during the recovery journey.As we conclude, Dr. Amonoo offers final advice to listeners: don't worry alone. Leverage your clinical team and support networks to navigate the challenges of recovery. This collaborative approach can significantly enhance the quality of life for both patients and caregivers.More:GVHD Upside Down Facebook Group: https://www.facebook.com/groups/gvhdupsidedownElephants and Tea: https://elephantsandtea.comNational Bone Marrow Transplant Link - (800) LINK-BMT, or (800) 546-5268.nbmtLINK Website: https://www.nbmtlink.org/nbmtLINK Facebook Page:  https://www.facebook.com/nbmtLINKnbmtLINK YouTube Page can be found by clicking here.This season is made possible thanks to donations from Syndax and Incyte.https://syndax.com/https://incyte.com/  Follow the nbmtLINK on Instagram! https://www.instagram.com/nbmtlink/

This epsiode includes content related to reproductive organs and sexual health and may not be suitable for all listeners.In this episode, we speak with Dr. Oluwatosin "Tosin" Goje, an Associate Professor of OBGYN and reproductive biology at the Cleveland Clinic. We delve into the critical and often under-discussed topic of female sexual health issues related to chronic genital graft-versus-host disease (GVHD), a condition affecting many women post bone marrow transplant.Dr. Goje begins by highlighting the prevalence of sexual dysfunction among female survivors of malignancies, particularly those who have undergone bone marrow transplants. Astonishingly, 80% of female survivors report no significant improvement in their sexual function even five years post-transplant. This issue, often underdiagnosed and unspoken about, affects their quality of life despite their physical recovery.She explains that the persistent sexual dysfunction is multifactorial. Factors include the systemic effects of chronic GVHD, which can cause fatigue and changes in body appearance, making patients feel less attractive. Chronic genital GVHD specifically affects the vulva and vagina, causing changes like thickening, rawness, and atrophy, leading to pain with intimacy, burning, and even bleeding. Additionally, medications can alter libido, and the overall psychosocial burden of their diagnosis and treatment exacerbates these issues.Dr. Goje emphasizes the importance of a multidisciplinary approach to manage these problems. She details the symptoms of genital GVHD and the necessity of individualized treatment plans. Hormone replacement therapy is essential for those with premature ovarian insufficiency or menopause, which can be accelerated by the transplant. Vaginal estrogen or other moisturizers and lubricants are often required, along with immunosuppressants like topical clobetasol to manage inflammation.Communication emerges as a vital theme throughout our conversation. Dr. Goje stresses that healthcare providers need to proactively ask about sexual health issues. Patients, often so grateful for their survival, do not prioritize these concerns. Utilizing validated questionnaires can help initiate these crucial discussions and overcome hesitation to begin the conversation. For patients, Dr. Goji advises regular consultations with a gynecologist and open discussions about their medications and any sexual health issues they experience, even before diagnosis.Addressing the specific needs of younger women, Dr. Goje discusses options like egg freezing before treatment to preserve fertility. She also notes that many foundations and insurance plans provide financial support for these procedures.Dr. Goje highlights the various treatments available for managing sexual dysfunction, including the use of silicone dilators, surgical interventions, and laser therapy. She encourages couples to communicate openly about their sexual health and consider sex therapy or couples therapy to address issues together. For patients experiencing chronic vaginal pain or infections, she recommends appropriate medical treatments, including potential surgery or laser treatment. She emphasizes the need for accurate diagnosis and management.Finally, Dr. Goje shares poignant stories from her practice, illustrating her deep commitment to her patients' holistic health. She reminds us that the goal is not just survival but also ensuring a quality life post-treatment.In another episode this season, we discuss male sexual health as it relates to GVHD.More Information:Cleveland Clinic - https://my.clevelandclinic.orgReplens - https://www.replens.comLuvena -https://luvena.comRevaree Moisturizer: https://hellobonafide.com/products/revareeMonaLisa Touch Laser - https://www.smilemonalisa.comNational Bone Marrow Transplant Link - (800) LINK-BMT, or (800) 546-5268.nbmtLINK Website: https://www.nbmtlink.org/nbmtLINK Facebook Page:  https://www.facebook.com/nbmtLINKnbmtLINK YouTube Page can be found by clicking here.Thank you to our sponsors. This season is supported by a healthcare contribution from Sanofi  https://www.sanofi.com/ Follow the nbmtLINK on Instagram! https://www.instagram.com/nbmtlink/

In today's podcast, we have the pleasure of speaking with Angie Giallourakis, a dedicated advocate and founder of the Steven G. Cancer Foundation and Elephants and Tea. Angie shares her powerful story of being a caregiver to her son Steven, who battled cancer twice. Steven was first diagnosed with stage four osteosarcoma in 2006, and later with secondary acute myelogenous leukemia (AML) in 2008, necessitating a bone marrow transplant.Angie recounts the emotional and physical toll of Steven's journey, describing the intense periods of treatment and the unexpected challenges they faced. After his bone marrow transplant, Steven experienced graft-versus-host disease (GVHD). Angie shares vivid anecdotes, including a harrowing moment when Steven's salivary glands swelled, causing his face to balloon. This incident, among others, highlights the unpredictable nature of GVHD and the constant vigilance required from caregivers.Angie emphasizes the importance of stress management for caregivers. She advocates for finding personal ways to cope, whether through exercise, yoga, meditation, or prayer. Her own methods include Yoga Nidra, a type of meditation, and seeking solace in prayer. She also stresses the importance of good nutrition and staying hydrated, which can be challenging during long hospital stays.Drawing from her experiences, Angie advises caregivers to seek help when needed and to communicate openly with their loved ones and medical teams. She underscores the necessity of validating the patient's pain and symptoms, as Steven's experience with inflammation throughout his body was initially dismissed by some as psychological.The conversation shifts to Angie's founding of the Steven G. Cancer Foundation. Motivated by the outdated treatments Steven received, she aimed to raise awareness and fund research for adolescent and young adult (AYA) cancer. She also talks about Elephants and Tea, a magazine by and for cancer patients, founded with her son Nick. The magazine provides a platform for unfiltered stories from cancer patients and has expanded to include workshops, community support, and therapeutic resources.Angie's message to new caregivers is clear: understand the potential challenges, communicate effectively, and don't hesitate to ask for and accept help. She highlights the importance of social support, both for patients and caregivers, to navigate the emotional and physical demands of cancer treatment.As we wrap up, Angie encourages listeners to reach out to organizations, consume available resources, and connect with others in similar situations. Her final words resonate with a message of hope and validation: you are not alone in this journey.More:Steven G. Cancer Foundation: https://www.stevengcancerfoundation.orgElephants and Tea: https://www.elephantsandtea.comNational Bone Marrow Transplant Link - (800) LINK-BMT, or (800) 546-5268.nbmtLINK Website: https://www.nbmtlink.org/nbmtLINK Facebook Page:  https://www.facebook.com/nbmtLINKnbmtLINK YouTube Page can be found by clicking here.This season is made possible thanks to donations from Syndax and Incyte.https://syndax.com/https://incyte.com/ Follow the nbmtLINK on Instagram! https://www.instagram.com/nbmtlink/

In this episode, we chat with JR Brandt of Montana, an acute lymphocytic leukemia (ALL) survivor, about his journey through diagnosis, treatment, and living with chronic graft-versus-host disease (cGVHD). JR shares his initial diagnosis story, describing how what he thought was a minor infection led to a leukemia diagnosis complicated by the Philadelphia Positive chromosome. He underwent 26 days of chemotherapy and was eventually cleared for a bone marrow stem cell transplant at Stanford University in March 2017.JR discusses the onset of chronic GVHD symptoms about a year after his transplant, beginning with skin changes. He was treated with Rituxan infusions, which provided temporary relief. Over the years, as symptoms re-emerged, JR continued Rituxan treatments and adjusted his care plan, even after moving from California to Montana. He highlights the importance of finding and continuing care with familiar healthcare professionals, like his physician who (fortunately) moved to Billings Clinic.Beyond skin issues, JR describes experiencing joint tightness, dry eyes, dysphagia, and dry mouth. He mentions practical solutions like using Biotene toothpaste for dry mouth and preservative-free Refresh Plus eyedrops for dry eyes. JR also shares the importance of physical and occupational therapy, which helped him develop a personalized exercise routine. Over time, he transitioned to aquatic aerobics and massage therapy, finding these methods more effective for managing his symptoms.JR emphasizes the significance of staying active, despite physical limitations, by adapting activities like biking with an e-bike and engaging in water aerobics. He also discusses the importance of sun protection and practical tips for managing GVHD symptoms, like using a sun hat and sunblock.JR addresses the mental health challenges of living with chronic illness, equating his experiences to PTSD and stressing the importance of setting goals and making plans to stay motivated. He shares how maintaining an active lifestyle and staying connected with his family helps him manage anxiety and stress.When discussing his career, JR explains how his background in healthcare was both a benefit and a challenge. He advises others with disabilities to utilize vocational rehabilitation services to explore new career paths. JR also encourages being your own patient advocate, ensuring all medical information is shared among healthcare providers to provide comprehensive care.JR concludes with the importance of using available resources, like the Americans with Disabilities Act, for mobility aids and other accommodations (link below). He highlights the need for continuous learning and resourcefulness in managing chronic GVHD and living life to the fullest. Products mentioned by JR in this episode:Refresh Eye Drops: https://www.refresheyedrops.com/Biotene for Dry Mouth: https://www.biotene.com/DaBrim Helmet/SunShade: https://dabrim.com/Oofos shoes: https://www.oofos.com/Mechanix Gloves: https://www.mechanix.com/Dycem Non-Slip tape: https://www.dycem-ns.com/Tryvaya (Prescription) Nasal Spray for Dry Eye: https://www.tyrvaya.com/Full list of Vocational Rehabilitation Agencies for all 50 states: https://rsa.ed.gov/about/statesAmericans With Disabilities Act (ADA) Requirements for Power-Driven Mobility Devices: https://www.ada.gov/resources/opdmds/This season is made possible thanks to donations from Syndax and Incyte.https://syndax.com/https://incyte.com/ Follow the nbmtLINK on Instagram! https://www.instagram.com/nbmtlink/

Emily Baumrin, MD interviewed by Steven Chen, MD, FAAD

Peter Gordon is no stranger to the National Bone Marrow Transplant Link.  The author of "Six Years and Counting: Love, Leukemia, and the Long Road Onward"  was very well received at our book club.  Today you'll hear his story.In 2008, this avid outdoorsman was living in the White Mountains of New Hampshire, and his girlfriend had just moved down from Montreal to marry him.  Soon after, he was diagnosed with leukemia and put on the transplant waiting list at Boston's Dana Farber Cancer Institute.  The wait for a donor was the hardest part for him, as weeks turned into months.Eventually, Peter did get his transplant and returned to his idyllic surroundings to recover.  Soon after, his new wife slipped on ice and shattered her knee and ankle.   Peter had to take the role of caregiver as he continued his own recovery. 14 years after his transplant, Peter still battles chronic Graft vs Host Disease.  During his treatment, he began writing a blog.  As Peter showed the outside world what his treatment was like, he discovered a passion for writing, eventually leading to the book.   He even has a section in the book on lessons for patients, called Many Medicines Besides Drugs.   Peter gives his advice, including writing down all of your symptoms, and understanding that your recovery will have peaks and valleys.  And you'll also hear a great piece of advice that Peter and his wife learned from - believe it or not - their cat, Gizmo. Link to Peter's Book: https://www.amazon.com/Six-Years-Counting-Leukemia-Onward/dp/1478750626Other ResourcesNational Bone Marrow Transplant Link - (800) LINK-BMT, or (800) 546-5268.nbmtLINK Website: https://www.nbmtlink.org/nbmtLINK Facebook Page:  https://www.facebook.com/nbmtLINKnbmtLINK YouTube Page can be found by clicking here.Peter's book Six Years and Counting: Love, Leukemia, and the Long Road OnwardPeter's Writer/Speaker Facebook pagePeter's  LinkedIn profileThank you to this season's sponsors:Thank you to our sponsors. This season is supported by a healthcare contribution from Sanofi  and The Leukemia & Lymphoma Society.https://www.sanofi.com/https://www.lls.org/patient-support 

The microbiome therapeutics market has been taking a beating, with several clinical-stage companies failing or flailing at the hands of tough financial markets and regulatory scrutiny. MaaT Pharma Founder & CEO Hervé Affagard knows these perils well. Affagard recently navigated his company through a protracted FDA clinical hold, emerging on the other side with a promising Phase 3 candidate in Graft versus Host Disease. On this episode of the Business of Biotech, Affagard offers a transparent look at how MaaT is beating the odds with a redundant clinical strategy and scrupulous cash management.Subscribe to the NEW #BusinessofBiotech newsletter at bioprocessonline.com/bob for more real, honest, transparent interactions with the leaders of emerging biotech. It's a once-per-month dose of insight and intel that you'll actually look forward to receiving! Check it out at bioprocessonline.com/bob!

Click here to claim CME/NCPD credit for this activity: https://i3health.com/oda-gvhd This audio includes both the additional updates interview and complete podcast from i3 Health's CME/NCPD activity New Opportunities for Improved Patient Outcomes in Graft-Versus-Host Disease. First, listen along as Dr. Shernan Holtan shares the latest data from the BTM CTN 1703 trial of posttransplant cyclophosphamide, tacrolimus, and mycophenolate mofetil as GVHD prophylaxis after allogeneic hematopoietic cell transplantation, then stay tuned after the interview to listen along to the full activity.

In this conversation, Daniel Belkin and Mitch Belkin interview Ross Levine, MD, PhD about Acute Myeloid Leukemia and its treatment. They discuss the different types of leukemias, the history of AML treatment, including chemotherapy and stem cell transplantation. They touch on Graft vs Host Disease, treatment after relapse, and open questions in leukemia, including future trials, and further investigation of ven/aza (Azacitidine/venetoclax).Who is Ross Levine?Dr. Ross Levine of the Memorial Sloan Kettering Cancer Center. Dr. Levine studies hematologic malignancies and is a world-renowned expert on myeloproliferative neoplasms and acute myeloid leukemia. Support the showFollow us at @ExMedPod Subscribe to our Youtube channelConsider supporting us on Patreon

In 2022, Dr. Shernan Holtan, Associate Professor at the University of Minnesota Medical School, recorded a CME/NCPD activity centered on new therapeutic avenues for improved patient outcomes in graft-versus-host-disease (GVHD). Recently, at the American Society of Hematology (ASH) Annual Meeting, she presented results of the BMT CTN 1703 trial, which investigated the efficacy of a GVHD prophylaxis regimen. While there, Dr. Holtan sat down with Oncology Data Advisor to discuss the potential of these results to change GVHD prophylaxis, as well as the other significant GVHD research presented at the meeting.   Click here to view and claim credit for New Opportunities for Improved Patient Outcomes in Graft-Versus-Host Disease, an accredited CME/NCPD activity provided by i3 Health: https://i3health.com/gvhd

The latest episode of the DDW Highlights podcast is now available to listen to below. DDW's Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates.  This week we learned the shocking statistic that a third of scientific researchers have, or know a close colleague who has, experienced abuse after posting research online. It wasn't all bad news, however, as top pharma CEOs committed to reducing the industry's carbon emissions and a new treatment for Graft vs Host Disease could be on the horizon. The drug discovery community also gained new insights into the inner workings of a new class of cancer drugs and how monkeypox adapts to evade treatments. 

Are you up to date on the latest approaches to treating chronic graft vs host disease? Credit available for this activity expires: 9/29/2023 Earn Credit / Learning Objectives & Disclosures: https://www.medscape.org/viewarticle/981569?src=mkm_podcast_addon_981569

Listen to a soundcast of the 8/24/22 and 8/26/22 FDA approvals of Imbruvica (ibrutinib) for pediatric patients with chronic graft versus host disease, including a new oral suspension, and Pemazyre (pemigatinib) for relapsed or refractory myeloid/lymphoid neoplasms with FGFR1 rearrangement.”

In this podcast from i3 Health gain expert insight and enhance your clinical knowledge with this case-based activity focusing on new and groundbreaking biomarkers used for diagnosis of graft-versus-host disease, factors for therapy selection, and clinical trial findings used to individualized treatment for patents, presented by leading faculty Shernan Holtan, MD, Associate Professor of Medicine, University of Minnesota, and Carrie Kitko, MD, Associate Professor of Pediatrics, Vanderbilt University Medical Center. Start the activity now! Click here to claim CME/NCPD/CPE credit: https://i3health.com/oda-gvhd

Today, Peg is joined by Heather Younker, RDN, CSO, a dietician at the John Theurer Cancer Center at Hackensack University Medical Center.  We cover all things related to Graft vs. Host Disease and diet. Nutrition is important for everyone, but especially those with GVHD, in order to prevent malnutrition and other issues.  Registered dieticians and nutritionists can be key in a multidisciplinary approach. It's important to keep your entire health care team in the loop so they can be aware of all issues. GVHD can present in many different ways and at any time.Symptom management is key for Heather and her coworkers.  This can be gastrointestinal issues related to GVHD, or side effects from various medications. Sometimes, this can cause a fear of eating, which can result in unhealthy weight loss and muscle mass. Sometimes food sensitivities can develop, such as one to lactose.  Maybe digestive enzymes are needed, or a change in diet.Oral care is also important, as GVHD can affect the mouth, teeth and throat.  Maybe softer foods are needed.  Maybe you'll need to stay away from acidic, citrus-ey foods.  Maybe pureeing foods can be helpful.   Heather even mentions a patient who pureed his whole breakfast of sausages, eggs and rice!Sometimes nutritional supplements like Ensure, Boost, or Orgain can be used to add calories and nutrients to the diet. And when it comes to smoothies, Heather prefers homemade to store-bought so that you can have more control over the ingredients.Hydration is important for everyone, but especially GVHD patients.   You need to moisturize your system inside and out, and there are many ways to do this besides just water.  Antioxidants found in fruits and vegetables are also key.Sometimes patients struggle with loss of appetite and other symptoms.  One way to ensure you're getting your needed calories, protein, vitamins, and other nutrients can be to eat smaller meals throughout the day instead of three large ones.  When your GVHD is active, you actually need more calories and nutrients.  And of course, exercise is key.Resources:Hackensack John Theurer Cancer Center: https://www.hackensackmeridianhealth.org/en/Services/Cancer-Care?fbclid=IwAR0ANqlbRxjJs_yJVG8YxzS9LW2YefeSBNzmmeJG85UyPZeVMM9KUbepY3QNational Institutes of Health (NIH) website: https://www.nih.gov/American Institute for Cancer Research: https://www.aicr.org/National Bone Marrow Transplant Link - (800) LINK-BMT, or (800) 546-5268.nbmtLINK Website: https://www.nbmtlink.org/nbmtLINK Facebook Page:  https://www.facebook.com/nbmtLINKnbmtLINK YouTube Page can be found by clicking here.Thank you to this season's sponsors:Pharmacylics: https://www.pharmacyclics.com/Janssen: https://www.janssen.com/Kadmon: https://kadmon.com/Sanofi: https://www.sanofi.com/

Today, survivor and advocate Meredith Cowden talks about being your own advocate regarding GVHD.  As patient advocacy director of the Meredith Cowden Foundation, she has a wealth of resources to share, many of which are linked below.  (If you'd like to hear a more detailed version of Meredith's story, you can listen to Season 6, Episode 4 of the Marrow Masters podcast here: https://marrowmasters.simplecast.com/episodes/meredithcowden )After a diagnosis of AML, Meredith received an allogeneic bone marrow transplant from her sister in September of 2001.  In October, she developed acute Graft vs. Host Disease, which later became chronic Graft vs. Host Disease.  She talks about the frustrating, unpredictable nature of cGHVD, and how she began looking for resources.   Unfortunately, Google was not very helpful.  After some collaborative work, she presented a comprehensive list of resources at the 2020 NIH Patient Advocacy Summit.  The list includes peer support groups, organization that can help with financial assistance, and more.We've got her entire list on our website here: https://www.nbmtlink.org/wp-content/uploads/2022/06/cGVHD_Resouces_2020_NIH_Summit.pdfMeredith talks about "spoon theory."  You only have so many spoons for your day- she explains. Meredith also talks about the Meredith Cowden foundation, and their GVHD symposium series going on in 2022-2023.There's a book that Meredith recommends, written about prednisone, from the perspective of a doctor and a patient.  It's called Coping with Prednisone and you can find it here: https://www.amazon.com/Coping-Prednisone-Revised-Updated-Cortisone-Related/dp/0312375603Meredith is now 20-years post transplant and recently turned 40.  We spend some time discussing how she's been able to decipher which physical elements are related to GVHD versus just getting older - something she didn't think about at the time of her transplant.We wrap up with more practical advice from Meredith.  She talks about deciding what your priorities are.  What's most important to you?  That can help you set a routine and find balance in your life.   And it's OK to say "no" to people sometimes.  Finally, be your own best advocate.  Don't be afraid to speak up with your doctors and be part of the conversation around medical care.More Resources:The Meredith A. Cowden Foundation: https://cowdenfoundation.org/Spoonie Day App:  https://www.spoonieday.com/The National Bone Marrow Transplant Link's updated book on Graft vs. Host Disease: https://www.nbmtlink.org/product/graft-versus-host-disease/National Bone Marrow Transplant Link - (800) LINK-BMT, or (800) 546-5268.nbmtLINK Website: https://www.nbmtlink.org/nbmtLINK Facebook Page:  https://www.facebook.com/nbmtLINKnbmtLINK YouTube Page can be found by clicking here.Thank you to this season's sponsors:Pharmacylics: https://www.pharmacyclics.com/Janssen: https://www.janssen.com/Kadmon: https://kadmon.com/Sanofi: https://www.sanofi.com/

Colorado's Ann Haehn and her daughter Genny are two truly special people.  Today, Ann takes us on their journey through Genny's transplant and subsequent battles with chronic Graft vs Host Disease.After a very grim diagnosis, Ann and the rest of Genny's village found a doctor that felt he could get Genny through transplant at Colorado Blood Cancer Institute. During a long six-month pre-transplant process, Ann moved in with Genny and her kids.  Genny's new boyfriend (now husband) Josh was also a huge help as well.After the transplant came 30 days of isolation, followed by 100 days of living in an apartment near the hospital.  That meant finding 130 days of child care, which Ann managed to do, with a lot of help from a lot of people, while she stayed with her daughter.  Then, two weeks prior to hospitalization, Ann lost her mom unexpectedly.Ann speaks candidly about what it took to get Genny through transplant and recovery, cleaning up puke, watching the same movie over and over again when Genny kept falling asleep, laughing, crying, blogging, and even some wine for Ann at the end of the night.Caregivers are expected to be stoic and talks about dealing with her emotions and being a human herself. This includes maintaining the mother-daughter relationship through the caregiver-patient one.After transplant, Genny developed GVHD, which at first was a good sign because it meant the transplant was working.  Over time though, this developed into chronic GVHD, which affected Jenny's joints and ability to walk.  She sometimes needed a cane, walker, or wheelchair.Before treatment, Ann promised Genny a trip to Europe.  And when she was well enough, the whole family went - with a wheelchair, IV bags, medication, and more.  You'll crack up as Ann tells you the hilarious moments of this trip.  Essentially, they found a way to do what they wanted to do, in spite of Genny's GVHD.Ann talks about how far GVHD treatment has come, and how Genny's GVHD seemed to "level off" after about six years.  While the unpredictability of this disease can be frustrating, for most, brighter days are ahead.Finally, Ann describes her experience as a caregiver in three words. "A sacred honor."Ann and Genny's experience led them to create an organization called Genny's Hope, which has recently joined the Small Choices Foundation, started in fact, by one of Genny's nurses!  Links Below.Resources:Small Choices Foundation: https://www.smallchoicesfoundation.org/Genny's Hope: https://www.smallchoicesfoundation.org/gennyshopeNational Bone Marrow Transplant Link - (800) LINK-BMT, or (800) 546-5268.nbmtLINK Website: https://www.nbmtlink.org/nbmtLINK Facebook Page:  https://www.facebook.com/nbmtLINKnbmtLINK YouTube Page can be found by clicking here.Thank you to this season's sponsors:Pharmacyclics: https://www.pharmacyclics.com/Janssen: https://www.janssen.com/Kadmon: https://kadmon.com/Sanofi: https://www.sanofi.com/

Heather Jim, PhD,  is a senior member and co-leader of the Health Outcomes and Behavior Research Program at Moffitt Cancer Center in Tampa.  Today she walks us through ways to combat sleep issues related to chronic Graft vs. Host Disease.  Hopefully the tips here will help all of us get a better night's sleep.Heather begins by walking us through the importance of sleep, and how that changes as we age.  Interestingly, 30% of the general population report sleep problems, but for transplant recipients, that number can rise as high as 60%. We cover some of the most common types of sleep issues, including sleep apnea, insomnia, and restless leg syndrome.While there are sleeping medications out there, Heather explains Cognitive Behavioral Therapy for Insomnia, or CBTI.  While there are psychologists and social workers who specialize in CBTI, there are many practices we can all employ on our own, to stop sabotaging our sleep cycles.  This includes mobile apps, linked below in our show notes.There are seven rules CBTI rules to help improve sleep:Set aside an hour to wind down before bed (this includes turning screens off!)Only go to bed when you start to feel sleepy.If you can't fall asleep in 20-30 minutes, get up and do something boring.Use an alarm clock to get out of bed at the same time every day.Use your bed and bedroom only for sleep and sexual activities.Limit naps during the  day, especially after 1pm.Limit the time spent in bed to actual time sleeping.Heather explains that good quality sleep is not only important for patients, but for caregivers as well.  Sometimes, transplant can be more stressful for the caregiver, and if they don't take care of themselves, it will harm their ability to help their patients.Resources:Shut Eye App: https://www.shuteye.ai/Somryst App: https://www.somryst.com/Calm App: https://www.calm.com/Heather Jim's Bio: https://moffitt.org/research-science/researchers/heather-jim/National Bone Marrow Transplant Link - (800) LINK-BMT, or (800) 546-5268.nbmtLINK Website: https://www.nbmtlink.org/nbmtLINK Facebook Page:  https://www.facebook.com/nbmtLINKnbmtLINK YouTube Page can be found by clicking here.Thank you to this season's sponsors:Pharmacyclics: https://www.pharmacyclics.com/Janssen: https://www.janssen.com/Kadmon: https://kadmon.com/Sanofi: https://www.sanofi.com/

Dr. Sean Smith is the director of the cancer rehabilitation program at Michigan Medicine, in Ann Arbor, as well as an associate professor at the University of Michigan. He's dedicated to helping patients improve function as it relates to a variety of musculoskeletal, neurological and cognitive deficits related to cancer and its treatment.Dr. Smith says every patient is different, and they may try many treatments at once to find the best fit for each individual situation.  The sooner he and his team can intervene, often the better the results.Skin and muscle tightening can sometimes occur with chronic GVHD.  One of the first treatment methods is stretching - whether that's giving a patient stretching exercises to do or employing the help of a physical or occupational therapist.   There are also other methods to break up scar tissue.  Other tactics may include cortisone injections, paraffin baths, and oral or topical steroids.  Dr. Smith explains how these tools are used. Fatigue is a very common issue relating to chronic Graft vs. Host Disease.  This can be due to anemia, drug side effects, poor sleep, and other factors. Our guest walks through treatment of each of these individual symptoms.Exercise, mindfulness, and even meditation are key tools in Dr. Smith's toolbox.  Your definition of exercise may be different than before transplant, but spending the time doing what you can is so important.  He shares some sobering numbers about how quickly muscles can deteriorate after transplant if not used.   Dr. Smith also talks about "pre-habilitation" - the exercise you can do before transplant.Resources:Dr. Sean Smith Bio: https://medicine.umich.edu/dept/pmr/sean-r-smith-mdNational Bone Marrow Transplant Link - (800) LINK-BMT, or (800) 546-5268.nbmtLINK Website: https://www.nbmtlink.org/nbmtLINK Facebook Page:  https://www.facebook.com/nbmtLINKnbmtLINK YouTube Page can be found by clicking here.Thank you to this season's sponsors:Pharmacyclics: https://www.pharmacyclics.com/Janssen: https://www.janssen.com/Kadmon: https://kadmon.com/Sanofi: https://www.sanofi.com/

Juliane Belisle, MSW, LCSW-s, at Cancer Family Care in Cincinnati, provided counseling and other services to survivors and their families.  To outsiders, chronic Graft vs. Host Disease long haulers may appear fine.  Survivors have made it through transplant and the immediate aftermath.   But the unpredictability of cGVHD can lead to anxiety, depression, and despair and frankly, survivors get sick and tired....of being sick and tired.  And they have to learn how to "re-train their brain."  In this episode, Juliane shares self-care tips that are applicable not just to GVHD patients, but to all of us.At a basic level, going to a treatment center can trigger our brain's "fight or flight" response.  This includes traumatic symptoms like irritability, loss of interest, numbing, and decreased concentration. Fighting the brain's limbic system can only make things worse.  Know that it's there to protect you.  Juliane talks about finding safeties, or even neutral things to focus on.Mindfulness is key.  Focusing on the future creates anxiety, and focusing on the past creates regret. Focusing on the present is a way to fight these feelings and eliminate our mental "pollution."  Juliane walks Peg and our audience through some breathing exercises that can help counteract our reactions to stress. (Just don't do these while driving!)Another tip is to focus on different senses - even something as simple as washing your hands can help refocus you.  There's also progressive muscle relaxation (link to a video below), and putting your feet up - way up - into an L shape.We often catastrophize our situation - imagining the worse case scenario.  Juliane often has her patients create a paper with 3 columns: in my control, out of my control, and within my influence.  She walks us through that exercise.Allow yourself to be worried or anxious, but limit that to a certain time period for the day. Self care is not selfish.  And just like we treat physical symptoms, we also need to take care of our minds as well.Resources:Progressive Muscle Relaxation: https://www.utoledo.edu/studentaffairs/counseling/anxietytoolbox/pmr.htmlJuliane's Bio: https://www.cancerfamilycare.org/clinical-profiles/?smid=2163National Bone Marrow Transplant Link - (800) LINK-BMT, or (800) 546-5268.nbmtLINK Website: https://www.nbmtlink.org/nbmtLINK Facebook Page:  https://www.facebook.com/nbmtLINKnbmtLINK YouTube Page can be found by clicking here.Thank you to this season's sponsors:Pharmacyclics: https://www.pharmacyclics.com/Janssen: https://www.janssen.com/Kadmon: https://kadmon.com/Sanofi: https://www.sanofi.com/

Season 7 of Marrow Masters focuses on chronic Graft vs. Host Disease sufferers, or GVHD "long haulers."  And our first episode is about an important topic that doesn't get enough attention - reproductive and sexual health.Dr. Areej El-Jawahri is an oncologist at Massachusetts General Hospital in Boston.   And while that is her primary role, her work experience has taught her about the need to focus on these issues.   A majority of transplant survivors struggle with sexual health issues and concerns regarding intimacy and fertility.  Dr. El-Jawahri gives us the hard numbers, as well as a wide array of symptoms and side-effects.She talks about the changing dynamic with couples when they become patient and caregiver, and how important it is to have open, honest communication regarding sexual health.  Often, a patient's concerns about their partner are misaligned with what their partner is actually prioritizing! Communication is also crucial with your medical team.  While these topics may sometimes be hard to bring up, they are important to discuss.  And today's methods of confidential, electronic communication may provide a vehicle for those who are uncomfortable having these discussions in an office setting.Dr. El-Jawahri also discusses fertility concerns for younger couples.  Often, and rightfully so, there is a rush to treat a patient's cancer.  But it may be worth consulting fertility specialists at the beginning of the process.Peg and today's guest also talk about different forms of intimacy.  While sex may be the first thing that comes to mind, there are other ways to be intimate and show each other attention and love.Finally, Dr. El-Jawahri tells us about the jaw-dropping question a patient asked her that prompted her to begin paying more attention to sex and intimacy with transplant survivors.Resources:Dr. El-Jawahri's bio: https://www.massgeneral.org/doctors/19647/areej-el-jawahriNational Bone Marrow Transplant Link - (800) LINK-BMT, or (800) 546-5268.nbmtLINK Website: https://www.nbmtlink.org/nbmtLINK Facebook Page:  https://www.facebook.com/nbmtLINKnbmtLINK YouTube Page can be found by clicking here.Thank you to this season's sponsors:Pharmacyclics: https://www.pharmacyclics.com/Janssen: https://www.janssen.com/Kadmon: https://kadmon.com/Sanofi: https://www.sanofi.com/ 

Marissa Z. Powell, PharmD, describes mechanisms of chronic graft versus host disease, recognizes historical approaches to treatment of chronic graft versus host disease, discusses recent updates in chronic graft versus host disease therapy. For more pharmacy content, follow Mayo Clinic Pharmacy Residency Programs @MayoPharmRes or the host, Garrett E. Schramm, Pharm.D., @garrett_schramm on Twitter! You can also connect with the Mayo Clinic's School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd. 

“Biomarkers give us information not only to diagnose a patient, but also to see whether a patient is going to have GVHD in the near future, whether a patient is going to respond to the treatment we'll give, and what would be the overall outcome and survival.” ONS member Nilesh Kalariya, PhD, AGPCNP-BC, AOCNP®, research nurse practitioner at MD Anderson Cancer Center in Houston, TX, talks with Stephanie Jardine, BSN, RN, oncology clinical specialist at ONS, about managing acute and chronic graft-versus-host disease (GVHD) and biomarkers for the condition. You can earn free NCPD contact hours by completing the evaluation linked in the episode notes.    Music Credit: "Fireflies and Stardust" by Kevin MacLeod   Licensed under Creative Commons by Attribution 3.0  Earn 0.5 contact hours of nursing continuing professional development (NCPD) by listening to the full recording and completing an evaluation at myoutcomes.ons.org by May 6, 2024. The planners and faculty for this episode have no relevant financial relationships with ineligible companies to disclose. ONS is accredited as a provider of NCPD by the American Nurses Credentialing Center's Commission on Accreditation.  Episode Notes  Check out these resources from today's episode:  Complete this evaluation for free NCPD.  Kalariya et al.'s Oncology Nursing Forum article: Diagnostic and Prognostic Biomarkers for Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation  ONS course: Hematopoietic Stem Cell Transplantation ONS Huddle Card™: Hematopoietic Stem Cell Transplantation ONS Voice articles about GVHD National Institutes of Health's GVHD Working Group reports UpToDate results for GVHD research  To discuss the information in this episode with other oncology nurses, visit the ONS Communities.   To provide feedback or otherwise reach ONS about the podcast, email pubONSVoice@ons.org. 

Listen to a soundcast of the December 15, 2021 FDA approval of Orencia (abatacept) for prophylaxis of acute graft versus host disease.

Dr Ray Koo, a haematologist specialising in allogeneic bone marrow transplants, joins Alex & Yvonne to discuss Graft vs Host Disease. From understanding the paradox of graft versus host disease and graft versus tumour effect,through to general treatment guidelines and take home messages. 

Rising physician Andrew Nguyen submits a case of GVHD. Let's talk about the hepatobiliary imaging findings, protocoling, and those "exploding crypts" on histology! Images found here 

Join us as we speak to Dr. Mariam Nawas and Dr. Satyajit Kosuri from University of Chicago Medicine, about graft-vs-host… The post Transplant Support and Graft-Versus-Host-Disease (GVHD) appeared first on The Bloodline with LLS.

Join us as we speak to Dr. Mariam Nawas and Dr. Satyajit Kosuri from University of Chicago Medicine, about graft-vs-host… The post Transplant Support and Graft-Versus-Host-Disease (GVHD) first appeared on The Bloodline with LLS.

Listen to a soundcast of the September 20 and 22, 2021, FDA approvals of Tivdak (tisotumab vedotin-tftv) for recurrent or metastatic cervical cancer with disease progression on or after chemotherapy, and Jakafi (ruxolitinib) for chronic graft-versus-host disease

Listen to a soundcast of the July 16, 2021 FDA approval of Rezurok (belumosudil) for adult and pediatric patients 12 years and older with chronic graft-versus-host disease after failure of at least two prior lines of systemic therapy.

Graft Versus Host Disease (GVHD), a recently published white paper by Dr. Steve Kleiboeker and the Eurofins-Viracor suite of tests for acute Graft Versus Host Disease: aGVHD Pre-Symptomatic Algorithm, aGVHD Symptomatic Algorithm, and aGVHD Post-Treatment Algorithm. Episode Links: Dr. Kleiboeker's white paper: Diagnostic Methods to Predict Outcomes for Acute Graft Versus Host Disease in Allogeneic Hematopoietic Cell Transplant Recipients Eurofins Viracor aGVHD Pre-Symptomatic Algorithm Eurofins Viracor aGVHD suite of tests Register for our product theater at #TCTM21 Abstract #102 Free Webinar - Thursday, February 25, 2021 | 4pm CST “Monitoring acute GVHD with biomarkers: How to interpret changes in the MAP” Presented by: Dr. James Ferrara of Icahn School of Medicine at Mount Sinai. Social Media: Linkedin   |   Twitter   |   Facebook For more information visit: Viracor-Eurofins.com or call (800)305-5198    

Dr. Selk interviews Dr. Michelle Jacobson, a gynecologist in Toronto, about graft versus host disease (GVHD). Topics covered include the definition of GVHD, counselling of stem cell transplant patients, assessing for genital GVHD, patient presentation, detecting GVHD in the context of menopause, physical features of genital GVHD, when to treat with surgery, recurrence risk, medical therapies and other treatments, vaginal creams versus ointments, treating post-menopausal women with vaginal steroids, the role of biopsy in diagnosis, and important information to communicate to your pathologist.

During the American Association of Cancer Research (AACR) Virtual Annual Meeting I, the MM Hub was pleased to speak to Christine Spencer, Parker Institute for Cancer Immunotherapy, San-Francisco, US and Diwakar Davar, University of Pennsylvania Medical Center, Pittsburgh, US. We asked: how can we use the microbiome to improve cancer immunotherapy and alleviate side effects such as graft-versus-host-disease?In this podcast, Dr Davar starts by providing a background on the importance of the microbiome in adaptive and innate immunity, while Dr Spencer states the importance of the cross-talk between the microbiome and immune system through microbial products, peptides, and metabolites. Dr Davar then explains the concept of immunosurveillance, immunoediting, and checkpoint inhibitors. Dr Spencer describes fecal microbiome transplant studies that showed features of the microbiome can predict response to immunotherapy and effect T-cell expression. Dr Davar then describes some of the studies that are looking at fecal microbiome transplant in combination with checkpoint inhibitors. He goes on to discuss studies investigating the use of live bacterial products to elicit the same effects as fecal microbiome transplant, particularly the mediation of CD8 T cells. Dr Spencer also talks about probiotics, antibiotics, and diet and explains how this can affect the gut microbiome and describes studies looking at these features in terms of response to immunotherapies. She also describes the microbiome research related to graft-versus-host-disease and the impact of higher alpha diversity on post-transplant survival, while Dr Davar explains how the microbiome may also affect toxicity and side-effects of cancer immunotherapies. Hosted on Acast. See acast.com/privacy for more information.