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In this episode, Ayesha speaks with Norman Putzki, MD, Senior Vice President and Global Development Head of Neuroscience and Gene Therapy at Novartis, about the complexities and real-world challenges of bringing new therapies to patients with neurological diseases. Dr. Putzki discusses the challenges and opportunities in developing treatments for complex brain disorders, and how gene therapy is being applied in neurological disease. Dr. Putzki transitioned from an academic career in clinical neurology, with a focus on diseases like multiple sclerosis (MS), to the pharmaceutical industry in 2010. Since then, he has taken on leadership roles in both medical and development functions, first at Biogen and later at Novartis, where he currently leads global development efforts in neuroscience and gene therapy. During his tenure at Novartis, he has been leading teams around the globe to various new indications, approvals and launches within the neuroscience portfolio. Dr. Putzki received his PhD from Essen University in Germany and completed residency training in Internal Medicine and Neurology in Essen, University College London (Institute of Neurology Queen's Square) and University of Berne (Switzerland). Dr. Putzki is an author/co-author of more than 50 peer reviewed publications and has authored 4 books. He is a fellow of the American Academy of Neurology. Tune into the episode to learn more about the current landscape of drug development in neuroscience and neurological diseases — from research and strategy to execution on a global scale. For more life science and medical device content, visit the Xtalks Vitals homepage. https://xtalks.com/vitals/ Follow Us on Social Media Twitter: https://twitter.com/Xtalks Instagram: https://www.instagram.com/xtalks/ Facebook: https://www.facebook.com/Xtalks.Webinars/ LinkedIn: https://www.linkedin.com/company/xtalks-webconferences YouTube: https://www.youtube.com/c/XtalksWebinars/featured
To celebrate DNA Day we are releasing our April episode exploring concepts related to the diagnostic odyssey, whole genome sequencing, and results returned. Segment 1: A Journey of Hope and Resilience In our first segment, we delve into the research conducted by Celine Lewis, focusing on the emotional impact of receiving a "no primary finding" (NPF) result from genome sequencing. This recent JoGC paper is titled, “The disequilibrium of hope: A grounded theory analysis of parents' experiences of receiving a “no primary finding” result from genome sequencing.” Celine's study uncovers the multifaceted journey of parents grappling with the absence of a definitive diagnosis for their children. Through grounded theory analysis, two primary themes emerge: "Striving to Solve the Unsolved Puzzle" and "Navigating Hope, Lost then Found." These themes encapsulate the oscillating emotions of hope, disappointment, and resilience experienced by parents amidst the diagnostic odyssey. Dr. Celine Lewis is a behavioural scientist working in the field of genetic and genomic medicine. She is currently at University College London Institute of Child Health, and is an NIHR Advanced Fellow. Her work focuses on how patients and families relate to, communicate and make decisions around personal genetic information, and the subsequent behavioural, psychological and social outcomes. Through her research, Celine has worked with a range of key stakeholders including researchers in the UK and abroad, healthcare professionals and policy makers as well as voluntary organisations, patients and families. She is regularly invited to present at UK and international conferences and meetings and is increasingly asked to present her research findings to organisations such as NHS England and the Department of Health. Key Insights from Segment 1: - The importance of understanding the emotional dimensions of genetic testing, especially for families receiving inconclusive results. - The dynamic role of hope as both a motivator and a coping mechanism throughout the diagnostic journey. - Suggestions for pre and post-test counseling strategies to support families navigating genomic testing, emphasizing the significance of managing expectations and fostering adaptive hope. Segment 2: Systematic Review of Secondary Findings In our second segment, we explore a systematic review conducted by Lucas Mitchell and Dr. Amanda Willis, focusing on the uptake and outcomes of returning secondary findings to research participants. This recent JoGC article is titled, “Systematic review of the uptake and outcomes from returning secondary findings to adult participants in research genomic testing.” Through rigorous analysis of existing literature, Lucas and Amanda illuminate key insights into the prevalence of secondary findings and their psychological, medical, and ethical implications. Their review underscores the critical role of researchers in navigating the complexities of result return, highlighting considerations for enhancing participant engagement and support. Lucas Mitchell is a research genetic counsellor at the Garvan Institute of Medical Research in Sydney, Australia. He contributes to the My Research Results genetic counselling platform, an evidence-based service that supports researchers in delivering actionable research genomic findings to participants nationwide. With a Master of Genetic Counselling from the University of Technology Sydney, Lucas is passionate about helping participants and their families in understanding their research findings and facilitating access to ongoing support. Lucas's current research interests lie within the application of genomics and returning secondary findings, and the intersection of genetic healthcare with diverse communities and improving inclusion and accessibility. Dr. Amanda Willis is a research genetic counsellor at the Garvan Institute of Medical Research. After completing a Master of Genetic Counselling in 2013, Amanda worked as a cancer genetic counsellor in Australia and the UK and completed a PhD in 2018. Amanda's current work is centred around the My Research Results program, developed to help research participants access their genetic information. Amanda provides genetic counselling to research participants who receive a genetic result and conducts research to understand the experiences of these participants. Through this work, she aims to increase access to genomic information and improve outcomes for research participants and their families. Key Insights from Segment 2: - The significance of secondary findings in research genomic testing and the need for comprehensive strategies to address participant needs. - Key findings regarding the uptake of secondary findings and diverse outcomes experienced by research participants. - Implications for researchers, healthcare providers, and policymakers in optimizing result return processes and promoting participant well-being. As we conclude our exploration, it becomes evident that genetic testing transcends the realm of science, delving deep into the intricacies of human emotions and resilience. Through the insightful research of our guests, we gain valuable insights into the lived experiences of individuals navigating genetic testing, offering a glimpse into the profound impact of hope, disappointment, and adaptive coping mechanisms. Stay tuned for the next new episode of DNA Dialogues! In the meantime, listen to all our episodes Apple Podcasts, Spotify, streaming on the website, or any other podcast player by searching, “DNA Dialogues”. For more information about this episode visit dnadialogues.podbean.com, where you can also stream all episodes of the show. Check out the Journal of Genetic Counseling here for articles featured in this episode and others. Nominate your articles, or a colleagues, here and we may feature it on the show! Any questions, episode ideas, guest pitches, or comments can be sent into DNADialoguesPodcast@gmail.com. DNA Dialogues' team includes Jehannine Austin, Naomi Wagner, Khalida Liaquat, Kate Wilson and DNA Today's Kira Dineen. Our logo was designed by Ashlyn Enokian.
Atypical Parkinsonian Syndromes, such as progressive supranuclear palsy (PSP), multiple system atrophy (MSA), corticobasal degeneration (CBD), and dementia with Lewy bodies are often initially diagnosed as Parkinson's disease. Incorrect, incomplete, or delayed diagnoses are barriers to beginning the most appropriate treatment early in the disease course. More research is needed to facilitate early diagnoses, understanding of disease pathogenesis, and monitoring of disease progression. However, largescale, collaborative initiatives are making meaningful progress in understanding genetic contributors to disease pathology and progression in Parkinson's disease. Our guest in this episode, Dr. Huw Morris, has spent more than twenty five years researching Parkinson's disease and parkinsonian syndromes, and he shares highlights from recent work, including studies on the genetics and pathogenesis of Parkinson's disease and other parkinsonian syndromes. Huw is Professor of Clinical Neuroscience at University College London Institute of Neurology, as well as an Honorary Consultant Neurologist at the Royal Free Hospital and the National Hospital for Neurology and Neurosurgery Queen Square. This podcast is geared toward researchers and clinicians. If you live with Parkinson's or have a friend or family member with PD, listen to The Michael J. Fox Foundation Parkinson's Podcast. Hear from scientists, doctors and people with Parkinson's on different aspects of life with the disease as well as research toward treatment breakthroughs at https://www.michaeljfox.org/podcasts.
The Parkinson’s Research Podcast: New Discoveries in Neuroscience
Atypical Parkinsonian Syndromes, such as progressive supranuclear palsy (PSP), multiple system atrophy (MSA), corticobasal degeneration (CBD), and dementia with Lewy bodies are often initially diagnosed as Parkinson's disease. Incorrect, incomplete, or delayed diagnoses are barriers to beginning the most appropriate treatment early in the disease course. More research is needed to facilitate early diagnoses, understanding of disease pathogenesis, and monitoring of disease progression. However, largescale, collaborative initiatives are making meaningful progress in understanding genetic contributors to disease pathology and progression in Parkinson's disease. Our guest in this episode, Dr. Huw Morris, has spent more than twenty five years researching Parkinson's disease and parkinsonian syndromes, and he shares highlights from recent work, including studies on the genetics and pathogenesis of Parkinson's disease and other parkinsonian syndromes. Huw is Professor of Clinical Neuroscience at University College London Institute of Neurology, as well as an Honorary Consultant Neurologist at the Royal Free Hospital and the National Hospital for Neurology and Neurosurgery Queen Square. This podcast is geared toward researchers and clinicians. If you live with Parkinson's or have a friend or family member with PD, listen to The Michael J. Fox Foundation Parkinson's Podcast. Hear from scientists, doctors and people with Parkinson's on different aspects of life with the disease as well as research toward treatment breakthroughs at https://www.michaeljfox.org/podcasts.
歡迎留言告訴我們你對這一集的想法: https://open.firstory.me/user/cl81kivnk00dn01wffhwxdg2s/comments 每日英語跟讀 Ep.K527: Why was the Turkey-Syria earthquake so bad? The magnitude 7.8 earthquake that struck Turkey and Syria on Monday last week is likely to be one of the deadliest this decade, seismologists said, with a more than 100km rupture between the Anatolian and Arabian plates. 地震學家表示,上週一襲擊土耳其和敘利亞的7.8級地震,可能是十年來傷亡最慘重的地震之一,安納托利亞和阿拉伯板塊之間斷裂了超過100公里。 Here is what scientists said happened beneath the Earth's surface and what to expect in the aftermath: 以下是科學家所描述地表下所發生的事,以及預期後果: WHERE DID THE EARTHQUAKE ORIGINATE? 震源位於何處? The epicenter was about 26km east of the Turkish city of Nurdagi at a depth of about 18km on the East Anatolian Fault. The quake radiated towards the northeast, bringing devastation to central Turkey and Syria. 震央位於土耳其城市努爾達伊以東約26公里處,深度約18公里,處於東安納托利亞斷層上。地震朝東北方向發散出去,蹂躪土耳其中部及敘利亞。 During the 20th Century, the East Anatolian Fault yielded little major seismic activity. “If we were going simply by (major) earthquakes that were recorded by seismometers, it would look more or less blank,” said Roger Musson, an honorary research associate at the British Geological Survey. 東安納托利亞斷層在二十世紀幾乎沒有重大地震活動。「如果我們只根據地震儀記錄的(大)地震來判斷,它看來多少是空白的」,英國地質調查局名譽研究員羅傑.穆森說。 Only three earthquakes have registered above 6.0 on the Richter Scale since 1970 in the area, according to the US Geological Survey. But in 1822, a 7.0 quake hit the region, killing an estimated 20,000 people. 根據美國地質調查局的資料,自1970年以來,該地區僅發生過三次芮氏6.0級以上的地震。但在1822年,一場7.0級地震襲擊了該地區,估計有兩萬人喪生。 HOW BAD WAS THIS EARTHQUAKE? 這次地震有多嚴重? On average, there are fewer than 20 quakes over 7.0 magnitude in any year, making last Monday's event severe. 平均來說,每年超過7.0級的地震只有不到20次,這讓上週一的地震變得非常嚴重。 Compared with the 6.2 earthquake that hit central Italy in 2016 and killed some 300 people, the Turkey-Syria earthquake released 250 times as much energy, according to Joanna Faure Walker, head of the University College London Institute for Risk and Disaster Reduction. 倫敦大學學院風險與減災研究所所長喬安娜‧佛爾‧沃克表示,與2016年發生在義大利中部、造成約300人死亡的6.2級地震相比,土耳其—敘利亞地震所釋放的能量,是義大利地震的250倍。 Only two of the deadliest earthquakes from 2013 to 2022 were of the same magnitude as last Monday's quake. 2013年至2022年傷亡最嚴重的地震中,只有兩次與上週一的地震震度相同。 WHY WAS IT SO SEVERE? 為何如此慘烈? The East Anatolian Fault is a strike-slip fault. 東安納托利亞斷層屬於橫移斷層 In those, solid rock plates are pushing up against each other across a vertical fault line, building stress until one finally slips in a horizontal motion, releasing a tremendous amount of strain that can trigger an earthquake. 在橫移斷層中,堅硬的岩石板塊在垂直斷層線上相互推擠,不斷增加壓力,最後造成一塊岩石板塊水平滑動,釋放出可引發地震的巨大壓力。 The San Andreas Fault in California is perhaps the world's most famous strike-slip fault, with scientists warning that a catastrophic quake is long overdue. 加州的聖安德列斯斷層或許是最著名的橫移斷層,科學家警告說,一場災難性的地震早該發生了。 The initial rupture for the Turkey-Syria earthquake kicked off at a relatively shallow depth. “The shaking at the ground surface will have been more severe than for a deeper earthquake of the same magnitude at source,” David Rothery, a planetary geoscientist at the Open University in Britain, said. 土耳其—敘利亞地震的斷裂是從深度較淺的地方開始。英國空中大學的行星地質學家大衛.羅瑟里表示:「相同的震級,若發生在地表,其震度將比震源更深的地震更加嚴重」。Source article: https://www.taipeitimes.com/News/lang/archives/2023/02/14/2003794282 Powered by Firstory Hosting
Pregnant women have consistently been underrepresented in clinical trials. With pregnancy studies posing significant risks to the mother and fetus, requiring extensive follow-up procedures, and potentially jeopardizing market approvals, many pharmaceutical companies avoid this demographic almost entirely. As a result, healthcare providers often struggle to access data regarding drug safety in pregnancy, preventing them from administering the best care possible. “Pregnant people make decisions in a vacuum of evidence. Very often, their healthcare providers don't know the evidence, so the women actually make the decision and take the risk that everyone else is ignoring. I think that has to stop,” says podcast guest Dr. Anna David, obstetrician and director of the University College London Institute for Women's Health. In this episode, host Deborah Borfitz speaks with David about the obstacles facing pregnant patients in today's medical landscape and the past and present strides made to increase their representation in clinical research. David also talks about her work creating the first standardized vocabulary for drug safety and maternal-fetal adverse events, how COVID-19 changed the industry's perspective regarding pregnancy studies, and the novel trials currently fostering change across the globe.Links from this episode: Clinical Research News University College London UCL EGA Institute for Women's Health Innovative Medicines Initiative ConcePTION Project Accelerating Innovation for Mothers International Council for Harmonisation Healthy Mum, Healthy Baby, Healthy Future Paediatric Investigation Plan (PIP) Maternal and Fetal Adverse Event Terminology
[News Focus 1]-European Union has begun to come up with emergency measures for soaring energy prices-유럽 연합 에너지 가격 급등에 극복 제안 Guest: Professor Paul Ekins from University College London Institute for Sustainable Resources Division of Resources and Environmental PolicySee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
In this installment of our podcast, we discuss climate change and how it affects health, directly and indirectly, from deepening food insecurity to facilitating the spread of infectious diseases. Our guests are Prof. David Pencheon, honorary professor of health and sustainable development at the University of Exeter in the United Kingdom and founder of the Sustainable Development Unit for NHS England, and Dr. Marina Romanello, a research fellow at the University College London Institute for Global Health and research director of the Lancet Countdown on Health and Climate Change. Fragments of the song "From Green to Red," featured in our podcast, were used with the permission of the artist, Beatie Wolfe.
Last week we attended the Alzheimer's Research UK Conference in Brighton. We took time out from the programme to talk with early career dementia researchers to ask them about their work, the challenges they have faced and how they overcame them, and to share a highlight from the conference. In this short interview we talk with Dr Emmanuelle Vire, Associate Professor in the University College London Institute of Prion Diseases. Emmanuelle explores if epigenetics is a hallmark of protein-based inheritance in neurodegeneration. Our research specifically investigates epigenetic mechanisms in human prion diseases. Emmanuelle and her colleagues employ a large array of technologies (transcriptomics, epigenomics, cell-based assays, animal models, patients samples) to determine if, where, when and how epigenetics contribute to disease susceptibility, onset, and progression. Using next-generation technologies we profile DNA, RNA, and histone modifications and identify disease-specific gene (coding and non-coding) signatures and pathways. Some their current projects also involve machine learning, nanopore sequencing, small molecule inhibitor and genome editing. Find out more about Emmanuelle and her work on our website: https://www.dementiaresearcher.nihr.ac.uk/profile-dr-emmanuelle-vire-university-college-london/ If you would like to join us and add your profile and short interview to our researchers profile, drop us a line to dementiaresearcher@nihr.ac.uk
We are grateful today to be joined by Dr James Mannion. James worked as a Science teacher for 12 years, and spent 8 years in school leadership roles. He has a Masters degree in Person-Centred Education from the University of Sussex, and a PhD in Learning to Learn from the University of Cambridge. James is a Bespoke Programmes Leader at the University College London Institute of Education. He is also the Director of Rethinking Education. --- Send in a voice message: https://anchor.fm/edufuturistspodcast/message
https://www.patreon.com/user?u=31723331 Francis Green is a Professor of Work and Education Economics in University College London Institute of Education. In this episode of The Know Show Podcast Francis discusses the huge problems with the private schooling system in Britain. He draws on his book Engines of Privilege, which he co-authored with David Kynaston. Listen to hear the way Francis articulately unpacks the ways private education is set up to benefit the society in which we live, and ways that we can push to reform this educational apartheid that exists. He clearly explains the way private schools are linked to the top universities and careers, and why it is so important we tackle this historical and entrenched system that persists. He shows why money should not be able to buy education, and highlights the inequality this bestows on society. PLEASE SUBSCRIBE TO THE CHANNEL to get access to the latest and most fascinating research!!! Get the latest episodes and videos on: https://theknowshow.net/ The Know Show Podcast makes the most important research accessible to everyone. Join us today and be part of the research revolution. Follow Us on Social Media: Instagram: https://www.instagram.com/theknowshow ... Twitter: https://www.instagram.com/theknowshow …
Dr. James Mannion is an education researcher and consultant who worked as a Science teacher for 12 years, and spent 8 years in school leadership roles. James has an MA in Person-Centred Education from the University of Sussex, and a PhD in Learning to Learn from the University of Cambridge. James's doctoral thesis is an evaluation of Learning Skills, a whole-school approach to teaching and learning that led to significant gains in subject learning, with accelerated gains among students from disadvantaged backgrounds. James works part-time as a Bespoke Programmes Leader at the London Centre for Leadership in Learning at the University College London Institute of Education. In this role, he works with teachers and schools throughout the UK to promote research-informed approaches to professional development and school improvement. James is a passionate advocate of practitioner inquiry as a basis for professional development, and he regularly presents at educational conferences on this subject. He is also a member of Oracy Cambridge, a study centre and think tank dedicated to promoting effective speaking and listening skills in schools and the wider society. James runs research-informed training and consultancy through Rethinking Education with Kate McAllister. In 2020, James co-authored Fear Is The Mind Killer: Why Learning to Learn deserves lesson time - and how to make it work for your pupils with Kate McAllister. Social Links Twitter: @RethinkingJames LinkedIn: @james-mannion Email: james@rethinking-ed.org
In this episode of CCYSC Awaaz, Joyeeta Dey and Dr. Amanda Gilbertson discuss their research on desegregation and the common school system in India, specifically in Lucknow. They analyze how a desegregation policy gets translated into an access policy by middle-class actors at various levels - from the state officials to public intellectuals to school leadership to teachers - and read against the grain of how the policy is interpreted by the poor families who avail of it. Dr. Amanda Gilbertson is a Senior Research Fellow in Anthropology at the University of Melbourne. Her research interests lie in the reproduction and contestation of class and gender inequalities in urban India. She is the author of Within the Limits: Moral Boundaries of Class and Gender in Urban India (Oxford University Press, 2017). Joyeeta Dey is an independent researcher, with seven years of work experience in the education development space in India. Currently she is working as a research associate for the University of Melbourne. She was an Erasmus Mundus student and also has a Masters in Sociology of Education from University College London - Institute of Education. Edited by Elizabeth Dillenburg (Assistant Professor, Department of History, The Ohio State University-Newark) Music: Little Idea by Scott Holmes (scottholmesmusic.com) / CC BY-NC
Oliver Cromwell once described English land law as “an ungodly jumble”. More than 350 years later, Dag Detter has a similar view of the way cities and countries value what they own. Their property and assets represent two times global GDP – almost twice the size of equity capital markets. Grouped in public wealth funds, they could release capital equal to 3% of annual GDP – $600bn in the US – for vital infrastructure spending.The fundamental problem, according to Detter, is that the public sector globally still uses cash accounting. This is a medieval method long left behind in the private sector by the accrual accounting innovation that helped develop capital markets, limited liability companies and the industrial revolutions that catapulted The Netherlands and Britain beyond Italian city states, funding transatlantic adventures and burgeoning empires.Detter, a Swedish former investment banker at BZE, Credit Suisse and BNP Paribas, now runs an eponymous corporate advisory consultancy advising on unlocking value from public assets and is not impressed with what he finds. “The public sector has no clue what it owns,” he says. “It doesn't have a balance sheet for its infrastructure, so doesn't understand what's coming in and what's going out. If you operated like this as a company or private individual, you'd probably go to jail.”Britain is a particularly egregious example. “They can't even find their real estate a lot of the time,” groans Detter. There's no Land Registry record of London's Liverpool Street Station and countless other pre-war public buildings, because they haven't changed hands in the last 50 years. “It's very convenient. If something isn't on the balance sheet, nobody will care to manage it. No-one will make sure you're using it in the best possible way.”Detter believes this led to Britain privatising its water utilities so cheaply in 1989. With century-old pipes leaking up to half their contents, the vast state borrowings needed to finance urgent investment were politically unacceptable. “The balance sheet wasn't connected to the profit and loss account and the budget, so the Government privatised the water utilities for next to nothing,” he says. “If it had a proper balance sheet, it could have carried out maintenance and registered at market value the increase in the value of the assets, which would be higher than the debt incurred. The Government would have looked like the prudent owner of a commercial asset.”Detter also criticises local authorities borrowing heavily from central government as well as paying top prices for commercial real estate without possessing institutions that can manage risk with proper accounting, capacity and professional management. “Governments throughout the world don't have that,” he says, pointing to Croydon Council in South London, which is facing effective bankruptcy after a series of property deals. The result is an awkward engagement with private capital through public-private partnerships. In Britain, Detter says the Private Finance Initiative has “screwed up and transferred undue wealth to the private sector”.No change of ownership needs to take place. Assets would simply be “placed into relevant packages” in public wealth funds operating as holding companies and using private sector accounting standards and transparency and governance models. Government-owned property would constitute two-thirds of the assets, with the remainder coming from operational assets, such as water and electricity utilities and public transportation systems. A report co-authored by Detter for University College London Institute for Innovation and Public Purpose, published in November, suggested separate public wealth funds for public venture capital, climate change mitigation and environmental protection and regional and urban economies. The cost to the public sector in the UK example is put at a maximum of 0.12% of GDP – £2.7bn a year.Public wealth funds are not a new idea. In Europe, they have been utilised in various different ways in Austria, Italy, Sweden, Denmark and Greece. In Asia, they have been spectacularly successful in Singapore. In the US, Detter says they could enable a city like Boston, with reported assets in 2014 of $3.8bn, including just $1.4bn of property, to leverage hidden wealth of $55bn in its real estate alone. He says accounting for market value at current use is “the first step towards quality asset management”. The next stage involves understanding the returns that could be earned on such trapped value.Detter was drawn into the public sector in the 1990s, helping restructure his nation's public assets as president of the Swedish government holding company, Stattum,. “It helped save Sweden from bankruptcy,” he says. He went on to advise private equity group Terra Firma Capital Partners and consulting firms McKinsey and Boston Consulting Group. “Financially, this is not rocket science,” he says. “It's very simple, but politically it's incredibly hard to do, unless you have a crisis, because it's all about political will. In the private sector, the game's about holding people responsible to deliver a certain result within a defined time. Politics is about promising things that can never be quantified.”“Whole of government accounts” have not helped much. “They don't include real estate and are published nine months after the fact, which means they're completely useless,” says Detter. “It's information that's nice to know, but you can't make decisions with it. It's like publishing English Premier League scores six months after matches have been played. Who cares? But nearly all governments do their accounting this way.”Except for New Zealand. This nation of 5m people manages its public assets “brilliantly,” according to Detter, publishing monthly public finance statements plus five and ten-year forecasts before elections or major policy decisions. Any policy suggestions in the run-up to an election are matched against forecast statements on the balance sheet. “The balance sheet comprises all the assets at market value, not historical value,” says Detter. “If Britain did things New Zealand's way, the discussion around Brexit would have been completely different. Instead of using silly numbers, arguments would have been based on net worth.”COVID-19 is an even better example. “One of the reasons New Zealand could act so quickly was because it could measure accurately, taking quick and hard action in the knowledge of whether it would pay off and whether it had the money to pay for it,” says Detter. “The Western world is going to be shocked and paralysed by debt incurred to fight COVID-19. Creating public wealth funds are one way of releasing capital without raising additional taxes or returning to austerity.”The idea may be catching on. With Citigroup seeing a need for global infrastructure spending of $58.6 trillion over the next decade, its special economic adviser Willem Buiter believes public wealth funds “make economic sense”. Financial Times commentator Martin Wolf adds that they're “an idea whose time has come.” Corralling capital in this way may be particularly suitable for governments determined to ‘level up' regional inequalities and ‘build back better' after COVID-19. “I've been trying to do this for the last 20 years and you could say it's been with limited success,” says Detter. Now this man from the nation of the midnight sun may get his moment in the limelight.
In this episode, Matthew interviews Prof Louise Archer (Karl Mannheim Professor of Sociology of Education at the University College London Institute of Education) on her research into education and inequality.
Presented and produced by Seán Delaney. On this week's podcast I speak to Dr. Karen Edge who is a Reader in Educational Leadership at the University College London Institute of Education. Karen Edge was a keynote speaker at the 2020 annual conference of the Irish Primary Principals' Network, the IPPN. Among the topics we discussed were the following: Helping principals make their job meaningful Constraints on principals working on teaching and learning and working with students and teachers include: to be accountable, to share information, manage data, manage external relations How principals can live a full life outside of work and be a leader in their work Helping principals align their professional priorities with what students, teachers and parents expect of them Supporting a new generation of principals from Generation X (born from 1965 to 1980) in schools designed for Baby Boomer principals who have now retired or who are retiring (those born from 1946 to 1964) Collaborative decision making and Generation X leaders How leadership in education differs across countries and continents and how this is influenced by being an adult in the wider society (and why borrowing policies from other countries may not work in the same way here). Rewards of being principal Why “being busy” is not a badge of honour How schools can productively partner with schools in other countries Among the people she mentioned on the podcast were the following: Dan Freedman- book series Jamie Johnson Judy Goldberg and Wondershift Viv Grant
Climate change is a conversation we need to be having in Intensive Care circles. Right now. If the environmental catastrophe that is unfolding around us continues unabated there may no longer even be Intensive Care Units. The rising global temperatures, the melting ice, the extreme weather events, and their impact on agricultural crops and human habitation may well lead to such a fall in the economy that our healthcare system may not have the financial resources it does now. And given ICUs are the most expensive part of our hospitals, have a guess what might disappear first. So who is there better to listen to about the climate crisis than British intensivist, Professor Hugh Montgomery, a deeply passionate and highly intelligent man, who was a founding member of the UK Climate and Health Council, and who has helped raise awareness about climate change for over 2 decades. In this episode Hugh outlines some simple things you can do today to help fight climate change. Hugh is a Professor and the Director of the Institute for Human Health and Performance at University College London. He obtained a 1st class degree in cardiorespiratory physiology and neuropharmacology before graduating from the Middlesex Hospital Medical School in 1987. He has since obtained specialist accreditation in Cardiology, General Internal Medicine and Intensive Care medicine, and practices as a Consultant Intensivist in North London in the UK. Hugh obtained his MD(Res) in 1997, is known for his pioneering genetic research, and has published over 450 peer reviewed papers, three in Nature. Hugh is also an author of children's books, and most recently of the medical thriller ‘Control’. Hugh has a such diverse array of interests and expertise that it’s hard to understand how he fits it all in. He has presented on television shows, climbed tall Himalayan mountains, run ultra-marathons, jumped naked from a plane at 14,000 feet, holds the world record for underwater piano playing, and also consults as a medical expert on Artificial Intelligence. Despite all of this, he continues to work as a clinical intensivist, publishes in the medical literature about important critical care topics, and is working to raise patient awareness about their end of life wishes. To me this is one of the most important Mastering Intensive Care episodes so far, as in a wide-ranging conversation Hugh talks about: How he became interested in physiology and then intensive care The intensivists that shaped his career Climate change and why we all need to care What actions we can take today as Intensive Care professionals to help the environment His own views on diet, renewable energy and international flights Some perspectives on the ICU ward round The importance of relationships and building connection with patients in clinical medicine How his father’s experience in hospital informed Hugh How “wisdom of the crowd” assists in making diagnoses Dealing with uncertainty at the bedside The importance of speaking to patients about end of life before they are admitted to the ICU How he speaks to families of the dying An end of life project he and his colleagues are working on Why he researches what he does Some tips for public speaking How the emergence of artificial intelligence might play out in healthcare Why we need to be engaged with Big Tech His own attitudes and practice of self-care and self development His non-medical writing, including his new medical thriller book “Control” I can not recommend more highly that you settle in and listen to this amazing man, Professor Hugh Montgomery. Andrew Davies -------------------- About the Mastering Intensive Care podcast: The podcast is aimed to inspire and empower you to bring your best self to the intensive care unit, through conversations with thought-provoking guests. The hope is you’ll glean insights to move you closer towards being the best and most human healthcare professionals you can be, so you can make the most valuable contribution to your patient’s lives. -------------------- Links related to Hugh Montgomery Hugh Montgomery at UCL Hugh Montgomery at Whittington Hospital Hugh Montgomery at ISEH Hugh Montgomery profile Hugh Montgomery on Twitter PubMed search for Hugh Montgomery Book “Control” (by Hugh Montgomery) Book “Control” (by Hugh Montgomery) Book “Control” (by Hugh Montgomery) Book “Cloudsailors” (by Hugh Montgomery) Book “Voyage of The Arctic Tern” (by Hugh Montgomery) Review of “Control” (by Hugh Montgomery) Article 1 about “Control” (by Hugh Montgomery) Article 2 about “Control” (by Hugh Montgomery) Interview of Hugh Montgomery on Desert Island Discs Interview of Hugh Montgomery on BBC Press article 1 featuring Hugh Montgomery Press article 2 featuring Hugh Montgomery Press article 3 featuring Hugh Montgomery Press article 4 featuring Hugh Montgomery Links to people, organisations and other resources as mentioned in order throughout podcast Physiologist Eric Neil Samson Wright’s Applied Physiology 13th edition Hammersmith Hospital Article discussing Ron Bradley Gillian Hanson Information about Hugh Montgomery’s 2019 talk at SMACC (video not released) Lancet Commissions 2009: “Managing the health effects of climate change: Lancet and University College London Institute for Global Health Commission” Lancet Commissions 2015: “Health and climate change: policy responses to protect public health” Lancet Countdown 2017: "The Lancet Countdown: tracking progress on health and climate change" Lancet Countdown 2018: "The Lancet Countdown on health and climate change: from 25 years of inaction to a global transformation for public health" Lancet Countdown 2018: "The 2018 report of the Lancet Countdown on health and climate change: shaping the health of nations for centuries to come" Lancet Countdown: Tracking Progress on Health and Climate Change Lancet on “Health and Climate Change” Lancet Infographic on “Climate Change and Health” Philosophical Transactions of The Royal Society Book “Eat & Run” (by Scott Jurek) Nature paper on microbiome and elite athletes Carbon Footprint Calculator SMACC Oli Flower Roger Harris CODA change Trillion Trees Trillion Trees Australia Whittington Hospital ITU/Critical Care University College Hospital London Andy Webb Reading Hospital YouTube search for Hugh Montgomery Moore’s law Deep Neural Networks Nature Medicine paper co-authored by Hugh Montgomery “Clinically applicable deep learning for diagnosis and referral in retinal disease.” Nature paper co-authored by Hugh Montgomery “A clinically applicable approach to continuous prediction of future acute kidney injury.” Google Health Particle physics New Normal Project podcast New Normal Project podcast - Episode 45 with Neal Barnard New Normal Project podcast - Episode 48 with Caldwell Esselstyn New Normal Project podcast - Episode 38 with Michael Klaper New Normal Project podcast - Episode 43 with Kim Williams New Normal Project podcast - Episode 49 with Scott Stoll New Normal Project podcast - Episode 51 with Alan Desmond “2040” Movie CODA 2020 Mastering Intensive Care podcast - Episode 48 with Laura Rock Links related to Mastering Intensive Care podcast Mastering Intensive Care podcast Mastering Intensive Care page on Facebook Mastering Intensive Care at Life In The Fast Lane Andrew Davies on Twitter: @andrewdavies66 Andrew Davies on Instagram: @andrewdavies66 Email Andrew Davies Audio Producer Chris Burke
Grainne Hallahan talks to Sally Franklin, senior teaching fellow from University College London Institute of Education, about making the most of another adult in the room See acast.com/privacy for privacy and opt-out information.
Dr. Adam Dubis is the Co-Investigator of the High-Resolution Imaging Group within the Department of Molecular Genetics at University College London Institute of Ophthalmology and Moorfields Eye Hospital NHS. He received his PhD from the Medical College of Wisconsin in Cell Biology, Neurobiology, and Anatomy. He went on to complete a postdoctoral fellowship at Duke University Medical Center's in the Department of Ophthalmology. Adam is with us today to tell us about his journey through life and science.
Necrotising enterocolitis (NEC) remains one of the primary causes of morbidity and mortality in neonates and alternative strategies are needed. Stem cells have become a therapeutic option for other intestinal diseases, which share some features with NEC. Along with colleagues, Simon Eaton and Paolo De Coppi, both from University College London Institute of Child Health, have tested the hypothesis that amniotic fluid stem (AFS) cells exerted a beneficial effect in a neonatal rat model of NEC.Mairi McLean discusses their findings with them.Read the full paper:Amniotic fluid stem cells improve survival and enhance repair of damaged intestine in necrotising enterocolitis via a COX-2 dependent mechanism http://goo.gl/EFUuN0
Hugh Montgomery, director of the University College London Institute for Human Health & Performance, talks about the space where climate, health, and international security meet. Christabel Owens, head of mental health research at the Devon Partnership NHS Trust, explains why warning signs for suicidal thoughts may not be visible to those best placed to spot them.
Dr Andreas Charidimou was presented with a prestigious Young Investigators Award at the European Stroke Conference 2012 in recognition of his research characterising the spectrum of transient focal neurological episodes in cerebral amyloid angiopathy. Dr Charidimou presented his paper “Clinical-radiological spectrum of transient focal neurological episodes in cerebral amyloid angiopathy: multicentre MRI cohort study and systematic review’ at the European Stroke Conference 2012. The International Journal of Stroke Managing Editor Carmen Lahiff-Jenkins spoke to Dr Andreas Chairdimou; clinical research fellow in Stroke at the University College London Institute of Neurology with Dr David Warring and Dr Roth Jager and doing my Phd in applied clinical neuroimaging of cerebral small vessel disease.
Tim Cacciatore, PhD is an Alexander Technique teacher, neuroscientist and currently a Senior Research Associate at the University College London Institute of Neurology in London England. In this interview he describes his research into muscle tone and movement coordination and how they are affected by Alexander Technique lessons. Tim's studies, Increased dynamic regulation of postural tone through Alexander Technique training and Prolonged weight-shift and altered spinal coordination during sit-to-stand in practitioners of the Alexander Technique can be read in full at alexandertechnique.com/research.htm Robert teaches in Lincoln, Nebraska and Toronto, Canada. Website: alexandertechniquenebraska.com. More information about the Alexander Technique: alexandertechnique.com