DOCS TALK SHOP

Surgery can wake up dormant cancer cells—even if the surgery is unrelated to cancer. In this striking episode, Drs. Dawn Lemanne and Deborah Gordon uncover how surgical trauma and anesthesia suppress immune function for weeks, creating an ideal window for tumor growth. Listen in as they discuss powerful, little-known tools to counteract this: a flu shot given within 24 hours before surgery can preserve immune surveillance; which painkillers to avoid after surgery; and how Cialis may reduce metastatic risk when used preoperatively. Bonus: Learn how heart rate variability reveals immune strength and insulin sensitivity. Dawn Lemanne, MD Oregon Integrative OncologyLeave no stone unturned.Deborah Gordon, MDNorthwest Wellness and Memory CenterBuilding Healthy Brains

Yes we all want to live longer, but the catch of course is -- so long as we are healthy!  What are some of the current thoughts about living longer and living better. How can we extend our vitality as we age, so that we celebrate health and not just more birthdays.Dawn Lemanne, MD Oregon Integrative OncologyLeave no stone unturned.Deborah Gordon, MDNorthwest Wellness and Memory CenterBuilding Healthy Brains

Your Bones Are Lying to You – What the Experts Aren't Telling YouIn this myth-busting episode, medical exercise specialist Andy Baxter flips everything you thought you knew about bone health upside down.Why Your Daily Walk--a False Security Blanket?Think walking strenghthens your muscles and protects your bones? Think again. Discover why it fails to give you what you really need to prevent life-altering falls—and what to do instead.Swimmers and Cyclists, Brace Yourselves…Low-impact exercise sounds great—until you hear why some athletes have weaker bones than couch potatoes.The CDC's Bizarre Osteoporosis ‘Cure'Would you believe field hockey for strenghthening bones was once an official recommendation? Find out what that says about mainstream osteoporosis advice—and why it's time to rethink it.80-Year-Old Diane's Secret to Jumping Higher Than YouAn explosive workout transformed this grandmother's strength—but there's a catch: your brain will actively try to stop you from doing the same. How to tame your brain so it is on the same team as your bones and joints.Your Brain Is Sabotaging Your JointsMeet neuromediation, the hidden reason arthritis pain worsens—and the surprising exercises that rewire your brain to fight back.Why Bone Density Scans Miss 80% of Fracture RisksYour DEXA scan isn't telling you the whole story. So what actually predicts a broken hip? The answer will change how you think about osteoporosis.Creatine + Coffee = Flushing $$$ Down the Drain?A world-renowned researcher shares a timing hack that makes supplements actually work. Here is a link to a dosing guideline mentioned in the episode. (You must be sure to check with your own doctor before starting any supplement!)Swimmers and Cyclists, Brace Yourselves…Low-impact exercise sounds great—until you hear why some athletes have weaker bones than couch potatoes.This isn't about aging gracefully—it's about aging powerfully. Ready to rewrite the rules? Listen now.Dawn Lemanne, MD Oregon Integrative OncologyLeave no stone unturned.Deborah Gordon, MDNorthwest Wellness and Memory CenterBuilding Healthy Brains

In this episode, we sit down with Dr.  Nick Norwitz, who is, in his own words, a researcher educator whose mission is to make metabolic health mainstream. Dr. Norwitz has a PhD in human metabolism from Oxford University and is about to get an MD from Harvard Medical School. We are interested here in his own story of healing chronic illness, in which modern standard medicine absolutely failed him and forced him to find his own path back to health. And this sheds a lot of light on the value of individualizing metabolic health care. And in fact, his story illustrates the n of 1 model of health care, which can often be the only way to work out the best diet or best therapy for whatever ails us and which I believe is the future of medicine.Doctor Norwitz also shares his insights about the process of human change and just exactly what motivated him when he knew he needed to make changes for his own survival. Join us as we chat with the very doctor Norwitz, and be sure to check out the show notes for links to all of his social media appearances. These are not only brilliant but highly entertaining.Here are links to just a few of his many ventures:https://www.youtube.com/@nicknorwitzPhDon X: https://x.com/nicknorwitzInstagram: https://www.instagram.com/nicknorwitz/ and for links to all his publications and writings, visit his website @ https://www.nicknorwitz.com/Dawn Lemanne, MD Oregon Integrative OncologyLeave no stone unturned.Deborah Gordon, MDNorthwest Wellness and Memory CenterBuilding Healthy Brains

In this episode of Docs Talk Shop, Dr. Lemanne and Dr. Gordon explore how daily rhythms impact cancer treatment, brain health, and metabolism. Discover surprising ways to optimize your health by carefully timing your sleep, light exposure, and meals. (And think twice about late suppers!)Breast cancers spread at night, and why this means trouble if your largest meal is supper.In colorectal cancer patients, morning chemo benefits men, while afternoon chemo benefits women.Light exposure at night disrupts sleep in everyone, immediately increasing the risk of diabetes and cancer.Vigorous exercise instantly creates cancer-killing effects in the blood that last for two hours.A single night of poor sleep causes high blood glucose and junk food cravings the very next day.References:Metastatic spread of breast cancer accelerates during sleep. Nature 2022https://pubmed.ncbi.nlm.nih.gov/35732738/Reducing nighttime light exposure in the urban environment to benefit human health and society. Science. https://www.science.org/doi/epdf/10.1126/science.adg5277. Accessed September 25, 2024.Effects of anthropogenic light on health. Science. https://www.science.org/doi/10.1126/science.adg3173. Accessed September 25, 2024.Light disrupts sleep and metabolic health. NPR. https://www.npr.org/sections/health-shots/2022/04/01/1089997121/light-disrupts-sleep. Accessed September 25, 2024.Disruption of sleep due to light exposure increases insulin resistance and heart rate. PNAS. https://www.pnas.org/doi/10.1073/pnas.2113290119. Accessed September 25, 2024.West KE, Jablonski MR, Warfield B, et al. Blue light exposure suppresses melatonin and impacts circadian rhythms. J Biol Rhythms. 2015;30(6):537-546. https://pubmed.ncbi.nlm.nih.gov/30311830/. Accessed September 25, 2024.Effects of artificial light at night on human health: a review of epidemiological studies. Int J Occup Med Environ Health. 2015;28(4):563-571. https://pubmed.ncbi.nlm.nih.gov/26375320/. Accessed September 25, 2024.Chronic sleep restriction minimizes circadian disruption, preserving glucose tolerance. Diabetes Care. 2021;44(3):839-844. https://pubmed.ncbi.nlm.nih.gov/34744800/. Accessed September 25, 2024.Circadian rhythms and cognitive function. Nat Rev Neurosci. 2023. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743892/. Accessed September 25, 2024.Hall J, Rosbash M, Young M. Nobel Prize in Physiology or Medicine 2017: research on circadian rhythms. Nobel Prize Press Release. https://www.nobelprize.org/prizes/medicine/2017/press-release/. Accessed September 25, 2024.Light at night and increased stroke risk. Stroke. 2024. https://www.sciencedaily.com/releases/2024/03/240325172425.htm. Accessed September 25, 2024.Association of light exposurDawn Lemanne, MD Oregon Integrative OncologyLeave no stone unturned.Deborah Gordon, MDNorthwest Wellness and Memory CenterBuilding Healthy Brains

Fecal transplants are saving cancer patients at MD Anderson? In this episode of Docs Talk Shop, Dr. Gordon and I explore how a major breakthrough in microbiome science could open up new treatment possibilities for cancer patients.But the news is not all good--fecal transplants can also transfer obesity. We discuss how a patient who received an FMT from an obese donor gained weight, highlighting just how powerful and influential the microbiome is in regulating metabolism.We discuss the remarkable ability of bariatric surgery ("stomach stapling," for obesity) to resolve type 2 diabetes in just a few days—long before any weight loss occurs, and the mind-boggling reason for this counterintuitive occurrence.Lifting weights is better than psychotherapy? Believe it or not, resistance training is found to be 1.5 times more effective than medication or talk therapy for treating anxiety and depression. And also in the realm of psychiatry, we explore Morgellon's disease. Patients with this condition report colorful fibers growing from their skin. Long considered a psychiatric disorder with delusions, (a misdiagnosis that has confined patients wrongly to inpatient mental health institutions) recent research finds a link between the colorful fibers of Morgellon's and Lyme disease.Join us as we explore unexpected solutions to the toughest health challenges.References:Morgellons disease psychiatric condition or spirochetal infection? National Center for Biotechnology Information. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647328/. Accessed September 24, 2024.Morgellons disease linked to infection. Dove Press. https://www.dovepress.com/getfile.php?fileID=69133. Accessed September 24, 2024.Links between Morgellons and Lyme disease. LymeDisease.org. https://www.lymedisease.org/links-morgellons-lyme-disease/. Accessed September 24, 2024.NAC alleviates OCD behaviors: Skin-picking, trichotillomania, etc. National Center for Biotechnology Information. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10909310/. Accessed September 24, 2024.The nucleus accumbens and its role in reward, addiction, and pain. National Center for Biotechnology Information. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6975138/. Accessed September 24, 2024.Defecation increases athletic performance by increasing brain oxygenation. PubMed. https://pubmed.ncbi.nlm.nih.gov/37102434/. Accessed September 24, 2024.Bariatric surgery decreases breast cancer risk. MDedge. https://ma1.mdedge.com/obgyn/article/269409/breast-cancer/bariatric-surgery-may-reduce-breast-cancer-risk-some?ecd=WNL_EVE_240603_mdedge. Accessed September 24, 2024.Infectious agents and cancer. National Center for Biotechnology Information. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10964319/. Accessed September 24, 2024.Infectious agents including SARS-CoV-2 linked to cancer. Frontiers. https://www.frontiersin.org/articles/10.3389/fcell.2022.8761Dawn Lemanne, MD Oregon Integrative OncologyLeave no stone unturned.Deborah Gordon, MDNorthwest Wellness and Memory CenterBuilding Healthy Brains

Cancer and Dementia: Coffee's Protection, Alcohol's Lasting DamageCould your morning coffee protect you from cancer? And could that evening glass of wine increase your risk? In this episode of Docs Talk Shop, we dig into the science behind two of the most popular beverages and unearth some surprising truths about how they impact your health, especially when it comes to cancer and dementia.For instance, regular coffee drinkers have up to a 20% lower risk of developing breast and colon cancer. Even more surprising, coffee's protective effects extend to brain health, reducing the risk of dementia. And if you're reaching for decaf, stop. Caffeinated coffee can increase muscle mass and boost physical activity. But decaffeinated versions don't offer the same benefits, proving it's the combination of caffeine and coffee's unique compounds that makes the difference.On the flip side, alcohol—even in moderation—raises your risk of several cancers, including breast, liver, and colon cancer. New research shows that no level of alcohol is truly safe when it comes to cancer, and the supposed cognitive benefits of moderate drinking have been debunked. In fact, alcohol contributes to brain shrinkage and increases the risk of dementia over time.If you're wondering how your daily habits might be affecting your long-term health, this episode is packed with insights that will make you rethink your approach to coffee and alcohol. Learn how to protect yourself from cancer and dementia by making smarter choices, starting with your next cup or glass.Alcohol and Cancer Risk“In women, breast cancer includes over half of all tumors caused by alcohol.”Source: Starek M, Rogalska A. Alcohol consumption and cancer risk. Pharmacological Reports. 2023. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889462/pdf/43440_2022_Article_426.pdf​:contentReference[oaicite:0]{index=0}Genetic Differences in Alcohol Metabolism“Individuals differ in their ability to metabolize ethanol through genetic differences in ADH [alcohol dehydrogenase].”Source: Starek M, Rogalska A. Pharmacological Reports. 2023. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9889462/pdf/43440_2022_Article_426.pdf​:contentReference[oaicite:1]{index=1}Alcohol and Cancer TypesCancers linked to alcohol include breast, colorectal, liver, pancreatic, and head/neck cancers.Source: Molina Y, et al. Alcohol and cancer risk: A global review. Epidemiol Health. 2023. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10867516/pdf/epih-45-e2023092.pdf​:contentReference[oaicite:2]{index=2}Alcohol and Cognitive DeclineModerate drinking increases cognitive decline by 10-15% in men consuming 3+ drinks per day.Source: Sabia S, et al. Alcohol consumption and cognitive decline in early old age. Neurology. 2014;82(4):332-339. doi:10.1212/WNL.0000000000000063​​Alcohol and SleepAlcohol reduces REM sleep, disrupts heart rate variability, and fragments sleep, worsening cognitive outcomes.Source: Walker M. Why We Dawn Lemanne, MD Oregon Integrative OncologyLeave no stone unturned.Deborah Gordon, MDNorthwest Wellness and Memory CenterBuilding Healthy Brains

As we age past our reproductive years, Mother Nature stops taking care of us. We discuss a recent article by Dr. Bruce Ames of the University of California, Berkeley, who's one of the first and most distinguished anti-aging scientists--still productive in his 90's! We uncover some of his secrets as we discuss why, as we age, certain supplements become even more important to our healthy survival. Some of our most valuable nutrients are in fact likely to be depleted with normal aging and there is an overlooked strategy to consider, choosing specific foods and supplements helpful for a long and healthy survival--long after our reproductive years!  Join us for this episode, and enjoy!Dawn Lemanne, MD Oregon Integrative OncologyLeave no stone unturned.Deborah Gordon, MDNorthwest Wellness and Memory CenterBuilding Healthy Brains

Can bad habits be good for you?  For instance, do cigarettes decrease the risk of Parkinson's disease? Alzheimer's? Ulcerative colitis? The answer is yes.  Smoking is surprisingly powerful as a preventive for these conditions. And you may also want to know that if you're worried about Parkinson's disease, you may want to think twice about living near a golf course.In this episode, Dr, Gordon and Dr. Lemanne discuss the surprising health benefits of some very unhealthy behaviors, and the hidden deadliness of vitamins, sleep aids, and, yes, golf courses. You'll learn that excessive sun exposure (carcinogenic) is extremely heart-healthy, and also decreases the risk of sustaining a broken hip. You'll hear about the perplexing connection between high vitamin B12 levels and increased cancer risk. After listening, you'll be more careful how and when you take vitamin D supplements, because you'll have learned that certain vitamin D schedules increase the risk of falls, and hence increase the rate of bone fractures.  Particularly surprising is the dual nature of polyphenols, found in brightly colored produce. Polyphenols provide the "color" in "eat the rainbow." They also, when consumed during pregnancy, are associated with increased rates of childhood leukemia.Finally, you may want to cover your ears when you hear how taking the popular antihistamine Benadryl for sleep might contribute to cognitive impairment. This episode is essential for anyone interested in the unexpected interplay between health habits and disease prevention, and in the nuances of practicing good medicine. (But please don't start smoking for health.)Dawn Lemanne, MD Oregon Integrative OncologyLeave no stone unturned.Deborah Gordon, MDNorthwest Wellness and Memory CenterBuilding Healthy Brains

 In this episode, Dr. Dawn Lemanne and Dr. Deborah Gordon engage with author and ketogenic diet specialist Miriam Kalamian, who shares her profound personal journey of treating her son's aggressive brain tumor with a ketogenic diet. The discussion delves into the diet's impressive effects on the size of her son's brain tumor, the surprising--and critical--role of calorie restriction for effective implementation of the keto diet in cancer, and the best combinations of fasting and the keto diet for optimal results. She outlines tailored dietary approaches for different cancers, and why keto is not "one size fits all" in cancer. For example,  for brain cancer, particularly glioblastoma, a strict ketogenic diet with very low carbohydrates and calorie restriction is essential to maximize ketone levels and minimize glucose. However, prostate cancer patients can follow a more moderate ketogenic diet, balancing carbohydrates to maintain quality of life and muscle mass, which is vital due to androgen deprivation therapy. Dairy fats are avoided in hormone-sensitive cancers but are acceptable for brain cancer due to their easy digestibility and lack of systemic effect.  She discusses her experience with exogenous ketones, and when she recommends those. Finally, Ms. Kalamian emphasizes the importance of professional medical advice when using diet as part of cancer therapy, and warns of the dangerous misinformation about the ketogenic diet on the internet, misinformation that often leads to poor outcomes. For instance, the common misconception that the ketogenic diet alone is a reasonable treatment for most cancers is dangerous.  This episode offers invaluable insights into the potential of metabolic therapy in cancer treatment. For more information on Miriam Kalamian's workHer website: https://www.dietarytherapies.comHer book: Keto for Cancer on AmazonDawn Lemanne, MD Oregon Integrative OncologyLeave no stone unturned.Deborah Gordon, MDNorthwest Wellness and Memory CenterBuilding Healthy Brains

We had a fascinating conversation with our friend and colleague Dr.Georgia Ede about the background, details, and the vast scope of her work treating mental illness--of all sorts--with variations on the ketogenic diet.  Fully conventionally trained, Dr. Ede used her insight into her patients' conditions, paired it with developing understanding about nutrition, and has found varied and individualized approaches to what we eat and how it affects our brains. We explore with Dr. Ede the applications of her dietary recommendations for conditions both psychiatric and neurological, the safety of her protocols, and the nutritional science as it applies to mental and physical health.We hope you enjoy this conversation, we certainly did!Dawn Lemanne, MD Oregon Integrative OncologyLeave no stone unturned.Deborah Gordon, MDNorthwest Wellness and Memory CenterBuilding Healthy Brains

In this episode, we discuss melatonin's use as a sleep supplement, as well as  its other powerful actions, such as its use as a pain reliever, an anti-anxiety medication, an antidepressant, and as a modulator of immune activity in autoimmune conditions. We also delve into melatonin's use in cancer, in particular in glioblastoma, where we look at a study showing a survival benefit to a particular melatonin protocol when combined with radiation. Our conversation also examines research suggesting that melatonin can be useful in providing protection from radiation damage, such as that that occurs during CT scans, X-rays, PET scans, and other high energy imaging studies. Then we discuss the controversy regarding the use of melatonin, especially in young people, and its dangers when used in the wrong setting, all of which leads us to insight into its different use  in older folks compared to younger ones, Dawn Lemanne, MD Oregon Integrative OncologyLeave no stone unturned.Deborah Gordon, MDNorthwest Wellness and Memory CenterBuilding Healthy Brains

Listen to this episode to learn:common blood pressure and diabetes medications that derail your fitness programsarcopenia of aging starts not in the muscles, but in the brainfitness to treat cognitive decline and neurologic disorders, Parkinson, MS, strokeyoga, and the surprisingly high risk of injury why stretching is harmful, and a better way to maintain range-of-motion  heart disease vs lung disease: the very different exercise rehab programs requiredrheumatoid arthritis, why your exercise program is all wrong, and how to fix itwhen to build muscle strength, and when to build muscle masswhy exercise is superior to calorie restriction for managing weightwhy COPD patients must limit aerobic exercise and should build muscle mass insteadDifferent types of exercise as medicine for aging, cancer, heart disease, high blood pressure, autoimmune conditions, dementia, osteoporosis, diabetes, lung disease/COPD and much more...Our guest is an elite rower turned Exercise Medicine specialist, author, inventor, and specialist in fitness over 50. Meet Andy Baxter. Besides designing exercise equipment to curtail injury in elite athletes, he runs two gyms locally that cater to those over 50, and works privately with anyone in need of his specialty, "Medical Exercise."Find Andy Baxter at Baxter Fitness Solutions.Read Andy Baxter's book "The Exercise Prescription."Dawn Lemanne, MD Oregon Integrative OncologyLeave no stone unturned.Deborah Gordon, MDNorthwest Wellness and Memory CenterBuilding Healthy Brains

In this episode, we talk about bone health--something that should be of interest to anyone over 50, long before it becomes a medical problem of concern. While Dr. Gordon has long relied on hormone replacement as a helpful tool in restoring lost bone density, she discusses today some of her recent learning about fine tuning the use of hormones and many other lifestyle choices. Bear with her pet peeves when it comes to standard of care, and pick up some tips you can incorporate into your own bone health routine. Perhaps even some you can share with your own physician!Dawn Lemanne, MD Oregon Integrative OncologyLeave no stone unturned.Deborah Gordon, MDNorthwest Wellness and Memory CenterBuilding Healthy Brains

In this episode, Dr. Lemanne and Dr. Gordon discuss why oncologists believe that cancers inevitably become resistant to any treatment, and the new research that is proving this wrong.On the surface, standard treatment choice for a particular cancer makes sense: 1. Choose the most powerful drug or drug combination possible, the one best at quickly shrinking the cancerous tumor.2. Repeatedly dose this drug/drug combination with as few interruptions as possible, and use the highest doses that the patient can tolerate.3. Stop only when the tumor becomes resistant to this treatment, that is, scans show growth, blood markers rise, or other signs of resumed cancer growth are detected.4. Then switch to a less effective regimen. 5. Repeat the above steps with new drugs until the patient dies. Yes, that is the expected end, and this is unpleasant end is acknowledged in the standard treatment protocols.But the problem is, this is the exact recipe that CAUSES treatment resistance in tumors, and makes them almost impossible to treat, much less cure.What if there was a relatively simple fix? Turns out, there is.This episode delves into a new paradigm in cancer treatment, a paradigm designed to prevent, or at least maximally delay the development of treatment resistance.  Based on mathematical modeling of tumor growth dynamics, this field uses the principles of ecology and evolution to drive tumors to extinction, or to control them indefinitely with "adaptive therapy." Dr. Lemanne discusses the research behind these advances, and the hope it brings to patients faced with previously "incurable" cancer. Dawn Lemanne, MD Oregon Integrative OncologyLeave no stone unturned.Deborah Gordon, MDNorthwest Wellness and Memory CenterBuilding Healthy Brains

Unlocking the Sweet Secrets of Cancer Prevention: A Journey with Dr. Lemanne, Dr. Gordon, and Sam AppleIn this thought-provoking episode, we explore the discovery of the link between diet, glucose metabolism, and cancer growth. Join us as we sit down with Sam Apple, the author of the compelling book, "Ravenous: Otto Warburg, the Nazis, and the Search for the Cancer-Diet Connection."Our guest, Sam Apple, tells the hidden story of Otto Warburg, a Nobel laureate who in spite of his Jewish heritage, not only survived Hitler's Germany, but uncovered the link between  sugar and cancer. Sugar, Cancer, and the Rise of Cancer RatesWe kick off our conversation with a startling revelation: Germany's financial ruin and desperate quest to compete with sugar-cane-producing European powers drove the mass cultivation of sugar beets for table sugar production. Sam Apple points out how this historic shift in diet and the rampant consumption of sugar may have played a pivotal role in the alarming rise of cancer rates over the past two centuries. Prepare to be astounded by the unexpected connection between sugar, cancer, and world history.Hitler's Sugar Addiction and Ironic PhobiaAs we dig deeper into the narrative, we explore the eccentricities of history's most infamous dictator, Adolf Hitler. Discover how Hitler's insatiable sugar addiction led to the deterioration of his health, even causing his teeth to rot. The irony of Hitler's profound fear of cancer while he indulged in a sugar-laden lifestyle serves as a stark reminder of the hidden dangers lurking in our diets.Warburg's Survival and Post-War OstracismOtto Warburg survived Nazi Germany, only to find himself and his work shunned by the post-war cancer research establishment in the United States. This unfortunate political reality led to a nearly 100-year delay in connecting the dots between diet and cancer. Sam Apple's Personal TransformationOur guest, Sam Apple, shares the profound impact Otto Warburg's work had on his own lifestyle choices. Discover the dietary changes that Sam has embraced as he continues to uncover the secrets of cancer prevention, inspired by the remarkable legacy of Otto Warburg.Prepare to be captivated, enlightened, and inspired by this eye-opening conversation that bridges the gap between history, science, and personal wellness. Whether you're a cancer patient seeking new insights or someone passionate about preventive healthcare, this podcast promises to provide you with valuable knowledge that can transform your understanding of cancer prevention.More on Sam Apple Link to Ravenous: Otto Warburg, the Nazis, and the Search for the Cancer-Diet Connection Dawn Lemanne, MD Oregon Integrative OncologyLeave no stone unturned.Deborah Gordon, MDNorthwest Wellness and Memory CenterBuilding Healthy Brains

We start to sort through something that will likely be an ongoing topic of interest, namely the role of genistein, a phyto- or plant-sourced estrogen in both of our worlds. We explore its use in both estrogen-mimicking and estrogen-blocking for certain conditions of aging, bone and brain health, as well as cancer prevention and cancer survival. We'll touch on blue zones and some of the risks and benefits of various other members of the legume family. Let's listen in as Dr. Lemanne begins by explaining the role of a Catholic nun in all of this discussion.Dawn Lemanne, MD Oregon Integrative OncologyLeave no stone unturned.Deborah Gordon, MDNorthwest Wellness and Memory CenterBuilding Healthy Brains

Dr. Lemanne reveals to Dr. Gordon what she's learned from medical errors, both hers and those of other physicians, and discusses what patients need to do to protect themselves. Dawn Lemanne, MD Oregon Integrative OncologyLeave no stone unturned.Deborah Gordon, MDNorthwest Wellness and Memory CenterBuilding Healthy Brains

 In this episode, Drs. Lemanne and Gordon discuss the use of Creatine as a supplement with both aging patients and patients with cancer. Turns out it's a useful addition to protocols for aging men, aging women, those who are athletes, as well as people simply wanting better health in the face of cancer and other health challenges. Let's listen to their discussions and reasons for looking forward to unfolding of additional research about the use of Creatine. Dawn Lemanne, MD Oregon Integrative OncologyLeave no stone unturned.Deborah Gordon, MDNorthwest Wellness and Memory CenterBuilding Healthy Brains

In this episode Doctors Lemanne and Gordon talk about gum disease, considered a nuisance by most, but gum disease and tooth loss are actually life-threatening,  due to a strong, but rarely discussed connection with cancer and dementia.Dawn Lemanne, MD Oregon Integrative OncologyLeave no stone unturned.Deborah Gordon, MDNorthwest Wellness and Memory CenterBuilding Healthy Brains

In this episode Dr. Gordon discusses how aging increases protein requirements. We cover the pros and cons of vegetarianism and animal protein and we even touch upon the health benefits of raw liver.Dawn Lemanne, MD Oregon Integrative OncologyLeave no stone unturned.Deborah Gordon, MDNorthwest Wellness and Memory CenterBuilding Healthy Brains

In this episode, Drs. Lemanne and Gordon discuss research on the role of fasting in the treatment and prevention of cancer.  Dr. Lemanne discusses her personal experience of fasting, and how she uses fasting in the cancer clinic.Exactly when to fast for best cancer outcomeCombining fasting and chemotherapy improves survival--animal studiesTypes of fasts, including water fasts and dry fastsResearch on dry fasting and kidney function (prepare to be surprised)Eating dinner late increases cancer riskDaily intermittent fasting, minimum effective lengthExtended fastsMeth EMS, van Egmond LT, Moulin TC, Cedernaes J, Rosqvist F, Benedict C. Association of Daily Eating Duration and Day-To-Day Variability in the Timing of Eating With Fatal Cancer Risk in Older Men. Front Nutr. 2022 May 10;9:889926. doi: 10.3389/fnut.2022.889926. PMID: 35619965; PMCID: PMC9127957.Links and references of interest:Study evaluating the effect of late dinner on breast and prostate cancer risk Chemotherapy and timing of fasting, University of Southern California studyChemotherapy patients who fast report fewer side effects. Longo group, 2009UCSF fasting page has been taken down. Here is one from City of Hope Cancer Center, in southern California/ greater Los Angeles areaFasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy. Sci Transl Med. Longo group, 2012 PMID: 22323820Dawn Lemanne, MD Oregon Integrative OncologyLeave no stone unturned.Deborah Gordon, MDNorthwest Wellness and Memory CenterBuilding Healthy Brains

How easily do you fall asleep? If you're like most of us, sometimes sleep overcomes you and sometimes you actually have to pursue sleep, just to "catch" a few good hours.  Today Drs. Lemanne and Gordon talk about the role sleep plays in their work with patients, addressing cognitive, metabolic, and cancer-related issues. Links In this Episode1.  Heart Disease more risky for women than breast cancer.2.  Breast cancer usually not fatal.3.  Breast cancer linked to disrupted circadian rhythm.4.  Denmark compensates for breast cancer after night shift work.5.  Artificial (neon & otherwise) light at night increases risk breast cancer.6.  Healthy sleep stages help brain health.7.  Glymphatic system cleans brain during sleep. 8.  Autophagy also part of the daily brain-cleaning during sleep.9.  Older adults still add new brain cells. 10.  A week camping restores optimal sleep cycles. 11.  Breast cancer is seasonal 12.  Meal Timing Regulates the Human Circadian System. 13.  Night Eating Associated w/obesity and binge eating disorder.14.  Relationship between body temperature & sleep. 15.  Set a wake-up time to re-train sleep habits. 16.  Sleep restriction a therapy for insomnia.17.  Melatonin safety & utility in cancer treatment. 18.  Including: melatonin dosing does not down-regulate production and the pineal response to melatonin.19.  Lack of evidence for antihistamines' harming cognition.20.  Believing that you slept poorly affects your performance!Dawn Lemanne, MD Oregon Integrative OncologyLeave no stone unturned.Deborah Gordon, MDNorthwest Wellness and Memory CenterBuilding Healthy Brains

Do you know if you're harboring silent inflammation?  An easily available blood test will tell you.In this episode, Dr. Gordon and I discuss a few of our favorite and unusual medical tests, including how to predict longevity from a measure of grip strength and a special test of living blood cells that shows how well a patient can resist cancer growth. Why the health of your smallest blood vessels dictates your overall health and longevity picture, and how to measure this. How your "natural killer cells" are related to cancer, and the special blood test that can measure the fitness of these cells. Why medicinal mushrooms enhance health.And much more. Dawn Lemanne, MD Oregon Integrative OncologyLeave no stone unturned.Deborah Gordon, MDNorthwest Wellness and Memory CenterBuilding Healthy Brains

In this episode, Dr. Gordon discusses her recently published pilot trial in which she and three physician colleagues successfully treated patients with dementia. Evaluating cognitive impairment: subjective vs measurable? Distinguishing mild cognitive impairment from early Alzheimer's dementiaWhich interventions actually moved the needle?  Along the way, we dive into details on mechanisms.Time stamps with links to references and resources:11:51     Chewing enhances brain health 13:59    observational study of 10 patients with dementia undergoing lifestyle intervention “Reversal of cognitive decline:  A novel therapeutic program.” 15:11     CNS-Vital Signs test  22:29    Hormesis23:24     Intellxx DNA testing  https://www.intellxxdna.com/ 29:46     Cyrex testing36:00   Study: Do US patients on colon cancer chemotherapy have more side effects due to increased amounts of folic acid in enriched foods? 39:50     Link to Dr Gordon's mold you tube talk  41:15     Link to Dr. Gordon's recent research “Precision Medicine Approach to Alzheimer's Disease: Successful Pilot Project” in Journal of Alzheimer's Disease, 2022; 88(4): 1411-1421.46:52    Finland and Iceland high rates of AD    and “Why Does Finland have the highest dementia mortality rate?"47:10     Online resources for people who are still functioning very well, but believe themselves at risk for dementia·        BrainHQ ·        Brainjo·        Food for the BrainResources for a more intensive therapeutic approach·      Apollo Health Dawn Lemanne, MD Oregon Integrative OncologyLeave no stone unturned.Deborah Gordon, MDNorthwest Wellness and Memory CenterBuilding Healthy Brains

Episode 4 Hormones In this episode, Dr. Gordon discusses female hormones. She gives us a glimpse into their function and what happens to aging women as they lose those hormones in menopause. She also talks about the skillful use of hormone replacement to extend life and enhance its quality. For those women who don't or can't take the typical form of hormone replacement therapy,  she describes workarounds for benefit of both brain and bone health.Links to references and more reading on some of the topics mentioned:1.  Increased Alzheimer's Risk During the Menopause Transition 2.  Mercury and Lead toxicity in menopause-induced osteopenia3.  Estrogen receptors are complicated, we'll address in a future episode, but here's a brief, layman's terms summary. 4.  Comprehensive genetics testing provider, IntellxxDNA5.  Hormone replacement therapy  prescribed for women aged 57-82 was associated with a significant improvement in tests of cognitive function at 24 months.   6.  Testing estrogen metabolites in the urine.   7.  Foods included in a conventional Polish diet—cabbage and sauerkraut—are associated with a reduced risk of breast cancer in Polish migrant workers. 8.   Genistein can confer protection against bone loss  and is emerging as a therapeutic option against the pathogenesis of memory impairment.    Dawn Lemanne, MD Oregon Integrative OncologyLeave no stone unturned.Deborah Gordon, MDNorthwest Wellness and Memory CenterBuilding Healthy Brains

Have you ever wondered why some cancer patients unexpectedly recover?  In this episode, Drs. Lemanne and Gordon discuss the cases of four persons who survived a range of cancer diagnoses considered universally terminal. But instead of dying promptly, two left hospice to return to active, athletic lives for several years. Two others defied all odds to achieve apparent cures.  These four patients used radically different approaches.The four diagnoses include chronic lymphocytic leukemia (CLL), advanced ovarian cancer, metastatic prostate cancer, and metastatic melanoma.Several surprising ideas that come up in this episode include why having chemotherapy before surgery is often better than rushing to surgery, and how the principles of evolution (as in Darwin) are pointing to lighter, more infrequent cancer treatments as a way to prolong both healthspan and lifespan. Links, Episode 1: 1. MIT research demonstrating the detrimental effect of surgery on cancer metastasis.2. How Anesthetic, Analgesic and Other Non-Surgical Techniques During Cancer Surgery Might Affect Postoperative Oncologic Outcomes: A Summary of Current State of Evidence. 3. N of 1,  by Glenn Sabin and Dawn Lemanne, MD, MPH.  The popular book about Mr. Sabin's successful search for a cure for his "incurable" chronic lymphocytic leukemia. 4. Case report of durable CLL remission without standard systemic therapy: Lemanne D, Block KI, Kressel BR, Sukhatme VP, White JD. A Case of Complete and Durable Molecular Remission of Chronic Lymphocytic Leukemia Following Treatment with Epigallocatechin-3-gallate, an Extract of Green Tea. 5. Research demonstrating that maximal PSA suppression may be detrimental in advanced prostate cancer. Dawn Lemanne, MD Oregon Integrative OncologyLeave no stone unturned.Deborah Gordon, MDNorthwest Wellness and Memory CenterBuilding Healthy Brains