Podcasts about genistein

The Endocannabinoid System plays a crucial role in regulating cardiovascular, neurological, and immune functions through CB1 and CB2 receptors. • CB1 Activation: Associated with oxidative stress, inflammation, and increased cardiovascular risks such as myocardial infarction (MI), arrhythmias, and heart failure. • CB2 Activation: Primarily found in immune cells and linked to anti-inflammatory and protective cardiovascular effects. • Cannabis Use: High THC content or synthetic cannabinoids (e.g., Spice, K2) significantly increases the risk of cardiovascular diseases and psychiatric disorders. • Cannabis Use Disorder (CUD): Characterized by compulsive use despite adverse consequences, often co-occurring with depression, PTSD, and anxiety. • Potential Therapeutic Targets: CB1 antagonists (e.g., Genistein) and CB2 agonists are being explored for their ability to reduce inflammation and vascular damage while minimizing psychiatric side effects.   Future research is needed to clarify long-term cardiovascular effects, optimize cannabinoid therapies, and inform public health policies.

Summary In this Q&A of the Gladden Longevity Podcast, Dr. Jeffrey Gladden and Steve Reiter discuss the latest focus in therapies and protocols at Gladden Longevity as well as various topics related to brain health, men's physical and emotional health, and the importance of rejuvenation processes in combating aging. He talks about the diets, therapies and supplements used to optimize our brains and keep them young, and the role of brain frequency treatments in this arena. They touch on the struggles that may affect and age men faster and the importance of emotional and spiritual well-being. Dr. Gladden also explains the concept of placental rejuvenation factors and their potential for reversing age-related decline. Additionally, he answers an audience-submitted question, providing insights on osteoporosis, and gives dietary recommendations for menopause to a LIVE audience member that was able to watch the recording of this episode.   Takeaways Rejuvenation processes are important for combating aging and improving overall health. Placental rejuvenation factors can help rejuvenate the body by providing youthful factors and proteins. Brain frequency treatments can improve brain health and cognitive abilities. Emotional and spiritual well-being are crucial for overall health and longevity. Men's health can be improved through proper supplementation, resistance training, and emotional well-being. Osteoporosis can be addressed through hormone optimization, resistance training, and specific supplements. Dietary recommendations for menopause include estrogen-rich foods and supplements like genistein.   Articles, News and Supplements mentioned ·      HIGH HOPES: SCIENTISTS COULD BE ON THE BRINK OF A BREAKTHROUGH “CURE” FOR ERECTILE DYSFUNCTION https://www.the-sun.com/health/7052926/cure-erectile-dysfunction-penis/ ·      STUDY FINDS MICROPLASTICS IN HUMAN TESTICLES, WITH POSSIBLE EFFECTS ON SPERM COUNT AND FERTILITY https://www.mensjournal.com/news/microplastics-testicles-sperm-count-new-study ·      FATHERHOOD POSES A SERIOUS HIDDEN HEALTH RISK OTHER MEN DON'T FACE https://www.sciencealert.com/fatherhood-poses-a-serious-hidden-health-risk-other-men-dont-face ·      MALES CAN LIVE LONGER IF THEY ARE CASTRATED, CLAIMS RESEARCHER https://interestingengineering.com/culture/castrated-males-live-longer ·      STUDY: CERTAIN NUTRIENTS MAY SLOW BRAIN AGING https://medicalxpress.com/news/2024-05-nutrients-brain-aging.amp ·      SUPERAGERS' BRAINS SHOW SUPERIOR WHITE MATTER HEALTH, STUDY FINDS https://www.psypost.org/superagers-brains-show-superior-white-matter-health-study-finds/ ·      GENISTEIN https://gladdenlongevityshop.com/products/genistein-125-mg-60-vegcaps?_pos=2&_psq=gen&_ss=e&_v=1.0 ·      BRAIN FREQUENCY https://start.gladdenlongevity.com/bft   Send your Qs for future episdes! Email: podcast@gladdenlongevity.com   Reach out to us at: Website: https://gladdenlongevity.com/ Facebook: https://www.facebook.com/Gladdenlongevity/ Instagram: https://www.instagram.com/gladdenlongevity/?hl=en LinkedIn: https://www.linkedin.com/company/gladdenlongevity YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw   For the audience ·      Use code 'Podcast10' to get 10% OFF on any of our supplements at https://gladdenlongevityshop.com/ ! ·      Use code ‘gladden10' for 10% OFF your MIMIO at https://mimiohealth.myshopify.com?sca_ref=3658427.8wBLUxg4Lb  

On today's podcast Dr. Gillett and James O'Hara NP, discuss Endocrine Disruptors. Intro (00:00): What is an Endocrine Disrupter (00:29): A discussion on the concept of endocrine disruptors, substances that can interfere with the endocrine (hormone) system.Where Might You Be Exposed (02:07): Exploring potential sources of exposure to endocrine disruptors.Who Invited Phthalates (04:01): Discussion about phthalates, a type of chemical often used in plastics.We Consume a Credit Card Worth of Plastic a Week? (05:16): Exploring the potential impact of plastic consumption on a weekly basis.DEHP? (06:45): A specific type of phthalate, DEHP, is likely discussed in this section. Is it Causing Death? (08:32): Exploring methods to monitor exposure to endocrine disruptors and discussing potential health impacts, particularly on testosterone.Is Bottled Water Dangerous? (12:26): Discussion about the safety of bottled water and its potential association with endocrine disruptors.Oils? (16:03): Examining the role of oils in relation to endocrine disruptors.Phytoestrogens (19:50): A discussion on phytoestrogens, plant compounds with estrogen-like effects.Boiled Soy Beans (25:31): Discussing the effects of boiled soybeans, in relation to phytoestrogens.Is Genistein a SARM? (27:01): Exploring whether Genistein, a compound found in soy, is a Selective Androgen Receptor Modulator (SARM).Genistein effect on Estrogen Receptors (30:18): Discussing the impact of Genistein on estrogen receptors.Burger King's Impossible Burger (32:23): Discussing the ingredients and potential implications of Burger King's Impossible Burger.Soy Formula (34:38): Exploring the use and impact of soy-based formulas.Phytoandrogens (37:39): Discussing plant compounds with androgen-like effects.Phytoprogestins (41:00): A discussion on plant compounds with progestin-like effects.Apigen Reduces Risk of Breast Cancer (42:17): Exploring the potential benefits of Apigen in reducing the risk of breast cancer.Androgen Endocrine Disrupters in the Water (44:15): Discussing the presence of androgen agonist endocrine disruptors, potentially referencing Tren (Trenbolone), in water.Outro (49:41):Studies/References ► https://www.sciencedirect.com/science/article/pii/S2666911022000247► https://www.sciencedirect.com/science/article/abs/pii/S0304389422014820► https://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr3494► https://orbi.uliege.be/bitstream/2268/254582/1/Exposure to endocrine-disrupting chemicals in the USA.pdf► https://pubmed.ncbi.nlm.nih.gov/36209923/► https://nyulangone.org/news/cnn-health-endocrine-disrupting-chemicals-consumer-products-linked-early-death-study-finds► https://pubmed.ncbi.nlm.nih.gov/24016262/► https://pubmed.ncbi.nlm.nih.gov/18558591/► https://www.researchgate.net/publication/7331610_A_newly_constructed_and_validated_isoflavone_database_for_the_assessment_of_total_genistein_and_daidzein_intake► https://pubmed.ncbi.nlm.nih.gov/14654166/► https://pubmed.ncbi.nlm.nih.gov/11305594/► https://pubmed.ncbi.nlm.nih.gov/21854827/► https://gamefaqs.gamespot.com/boards/267-food/78317332► https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533519/► https://pubmed.ncbi.nlm.nih.gov/23754792/► https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705436/► https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851288/► https://doi.org/10.1093/beheco/ary121► https://www.sciencedirect.com/science/article/abs/pii/S0166445X23001807For High-quality labs:► https://gilletthealth.com/order-lab-panels/For information on the Gillett Health clinic, lab panels, and health coaching:► https://GillettHealth.comFollow Gillett Health for more content from James and Kyle► https://instagram.com/gilletthealth► https://www.tiktok.com/@gilletthealth► https://twitter.com/gilletthealth► https://www.facebook.com/gilletthealthFollow Kyle Gillett, MD► https://instagram.com/kylegillettmdFollow James O'Hara, NP► https://Instagram.com/jamesoharanpFor 10% off Gorilla Mind products including SIGMA: Use code “GH10”► https://gorillamind.com/For discounts on high-quality supplements►https://www.thorne.com/u/GillettHealth#hormones #podcast #plastic #food #health #gilletthealthAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

We start to sort through something that will likely be an ongoing topic of interest, namely the role of genistein, a phyto- or plant-sourced estrogen in both of our worlds. We explore its use in both estrogen-mimicking and estrogen-blocking for certain conditions of aging, bone and brain health, as well as cancer prevention and cancer survival. We'll touch on blue zones and some of the risks and benefits of various other members of the legume family. Let's listen in as Dr. Lemanne begins by explaining the role of a Catholic nun in all of this discussion.Dawn Lemanne, MD Oregon Integrative OncologyLeave no stone unturned.Deborah Gordon, MDNorthwest Wellness and Memory CenterBuilding Healthy Brains

Does soy cause cancer or fight cancer? Dr. Ralph W. Moss, and son Ben discuss some definitive studies and the effect soy can have on the body. Program Notes: Soy food intake after diagnosis of breast cancer and survival: an in-depth analysis of combined evidence from cohort studies of US and Chinese women1,2,3 A randomized trial of the effect of a plant-based dietary pattern on additional breast cancer events and survival: the Women's Healthy Eating and Living (WHEL) Study Soy intake and breast cancer risk: a prospective study of 300,000 Chinese women and a dose-response meta-analysis Ralph's Smoothie Recipes Eden Black Soy Beans  For Dr. Moss' recommended products list, please visit https://www.themossreport.com/recommended-products/ [Affiliate Links]

Episode 4 Hormones In this episode, Dr. Gordon discusses female hormones. She gives us a glimpse into their function and what happens to aging women as they lose those hormones in menopause. She also talks about the skillful use of hormone replacement to extend life and enhance its quality. For those women who don't or can't take the typical form of hormone replacement therapy,  she describes workarounds for benefit of both brain and bone health.Links to references and more reading on some of the topics mentioned:1.  Increased Alzheimer's Risk During the Menopause Transition 2.  Mercury and Lead toxicity in menopause-induced osteopenia3.  Estrogen receptors are complicated, we'll address in a future episode, but here's a brief, layman's terms summary. 4.  Comprehensive genetics testing provider, IntellxxDNA5.  Hormone replacement therapy  prescribed for women aged 57-82 was associated with a significant improvement in tests of cognitive function at 24 months.   6.  Testing estrogen metabolites in the urine.   7.  Foods included in a conventional Polish diet—cabbage and sauerkraut—are associated with a reduced risk of breast cancer in Polish migrant workers. 8.   Genistein can confer protection against bone loss  and is emerging as a therapeutic option against the pathogenesis of memory impairment.    Dawn Lemanne, MD Oregon Integrative OncologyLeave no stone unturned.Deborah Gordon, MDNorthwest Wellness and Memory CenterBuilding Healthy Brains

Dr Kourtney Sims has an unusual combination of skillsets when it comes to menopause, and has really dedicated her continuing education post-medical school to understanding this transition. The Texas-based, North American Menopause Society-certified obstetrician-gynecologist is also an herbalist, a yoga teacher, and a functional integrative women's health advocate. And she's chief medical advisor to Phenology, which is a new US company led by former Silicon Valley executive Jess Graham aimed at offering relief and guidance to women through supplements and rescue remedies.Highlights:What MDs learn about menopause in medical schoolThe lack of oversight of menopause treatment How the system works in the UK (hint: it's driven by pharma)Her take on the “menopause is a disease” narrativeThe holistic, energetic, ritual-based view of menopauseDo worse symptoms mean larger health problems? Menopause hormone therapy, disease prevention, longevity and antiaging HRT + the individual Why other countries are doing research on herbs and not the US2 good herbs you may not have heard of for sleep + hot flashesTracking perimenopause by testing progesterone levelsWhat the women she sees who have an easier time have in commonWhere to find more: Web: DrKourtney.com, Myphenology.comAnd no affiliation, but if you wanted to check out Phenology, use code HOTFLASHINC for 10 percent off your order. SPONSORS:Become anti-flush cooling clothing | Now shipping to the US! | Use code HOTFLASHINC to get a 20 percent discountJoin the Hotflash Inc perimenoposse:Web: hotflashinc.comTikTok: @hotflashincInstagram: @hotflashincTwitter: @hotflashincEpisode website: HotflashincSee hotflashinc.com/privacy-policy for privacy information

Paul shares the results from his August Bloodwork panel from Marek Health. He does a deep dive into Testosterone, Immunoglobulin, Boron, Genistein, Isoflavonoids and touches on TMAO, Uric acid, and GGT. A note from Paul: Throughout my training and practice as a physician I have come to one very disappointing conclusion:  Western medicine isn't helping people lead better lives. Now that I've realized this, I've become obsessed with understanding what makes us healthy or ill. I want to live the best life I can and I want to be able to share this knowledge with others so that they can do the same. This podcast is the result of my relentless search to understand the roots of chronic disease. If you want to know how to live the most radical life possible I hope you'll join me on this journey. Time Stamps: 00:09:43 Podcast begins 00:12:08 Paul's lipid panel  00:14:48 Is elevated LDL a risk factor for heart disease? 00:24:08 Paul's Plasma, Ammonia results 00:25:28 Paul's Anemia profile 00:32:08 Paul's Blood Count profile 00:34:08 Paul's Thyroid panel 00:36:53 Comprehensive metabolic panel 00:38:13 Paul's Urinalysis 00:40:13 Paul's hormones 00:42:53 Insulin sensitivity  00:47:30 Boron 00:59:58 How to optimize your testosterone and increase androgen receptors 01:03:18 The detriments of consuming soy 01:05:43 Paul's thoughts on TMAO 01:09:40 Paul reviews the remainder of his bloodwork Sponsors: Heart & Soil: www.heartandsoil.co Sign up for Animal Based Gathering 2023: animalbasedgathering.com  Make a donation to the Animal Based Nutritional Research Foundation: abnrf.org   Marek Health: marekhealth.com/fundamentalhealth, use code PAUL for 10% off your first lab order Primal Pastures: www.primalpastures.com, use code CarnivoreMD for 10% off your first order Eight Sleep: www.eightsleep.com/carnivoremd for exclusive Labor Day Savings through 9/11 and to get $150 off your order White Oak Pastures: www.whiteoakpastures.com, use code CarnivoreMD for 10% off your first order or Carnivore5 for 5% off subsequent orders

On this week's podcast, Paul does a deep dive on all things Glyphosate. He also touches on the dangers of  PFAS, more reasons not to eat kale (Thallium), and why Genistein, found in soy and bean products, may be harmful for male hormones. A note from Paul: Throughout my training and practice as a physician I have come to one very disappointing conclusion:  Western medicine isn't helping people lead better lives. Now that I've realized this, I've become obsessed with understanding what makes us healthy or ill. I want to live the best life I can and I want to be able to share this knowledge with others so that they can do the same. This podcast is the result of my relentless search to understand the roots of chronic disease. If you want to know how to live the most radical life possible I hope you'll join me on this journey. Time Stamps: 00:09:15 Podcast begins 00:12:40 Are you eating Glyphosate in your “natural” foods? Does glyphosate cause cancer? 00:22:00 Thoughts on oats, grains and wheat 00:24:45 Glyphosate in beer and wine 00:26:05 Are pesticides really an issue? 00:30:30 Is organic food really better? 00:32:20 The science behind glyphosate 00:36:58 The importance of eating grass-finished beef 00:38:50 Research on glyphosate/RoundUp 00:56:20 Problems with soy and beans (Genistein + Glyphosate) 00:59:53 Get your glyphosate levels checked  01:00:35 The problems with kale 01:03:50 The contamination of kale with heavy metals (Thallium) 01:08:43 Summary of glyphosate awareness 01:11:52 Actionable steps to lower glyphosate exposure Sponsors: Heart & Soil: www.heartandsoil.co Sign up for Animal Based Gathering 2023: animalbasedgathering.com  Make a donation to the Animal Based Nutritional Research Foundation: abnrf.org   Primal Pastures: www.primalpastures.com, use code CarnivoreMD for 10% off your first order White Oak Pastures: www.whiteoakpastures.com, use code CarnivoreMD for 10% off your first order or Carnivore5 for 5% off subsequent orders Schwank Grills: schwankgrills.com, use code PAUL for $150 off a Schwank 1500 degree grill Ice Barrel: www.icebarrel.com, use code PAUL to get $125 off your order and FREE shipping.

Vidcast:  https://youtu.be/4Csxcu3sjuY   Those who smoke marijuana more than once of month are more likely to suffer a heart attack and frequent users are more likely than non-users to have their first heart attack before the age of 50.  Stanford University cardiologists now report these sobering facts following their analysis of half-million persons with clinical data and blood samples in the UK Biobank.   Their study revealed that THC, tetrahydrocannabinol, the psychoactive component of cannabis, binds to CB1 receptors in blood vessel linings and creates inflammatory damage of the sort associated with atherosclerosis.  These damaged blood vessels nourishing the heart and brain block leading to heart attacks and strokes.   The researchers used AI techniques to search for molecules capable of blocking CB1 receptors and found one called genistein.  Using a mouse model, they showed that genistein blocked THC-induced vessel damage while failing to interfere with THC's beneficial, pain-moderating properties.  Clinical studies lie ahead in order to prove the value of genistein in humans.   Meanwhile, know that marijuana is not entirely harmless.  Those with other factors predisposing them to vessel damage including high cholesterol, diabetes, and obesity, should be particularly wary about use and overuse of marijuana.    https://www.cell.com/cell/fulltext/S0092-8674(22)00443-3?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867422004433%3Fshowall%3Dtrue#%20   #cannabis #marijuana #thc #atherosclerosis #heartattack #stroke #genistein  

Welcome back to this week's #FridayReview.   Today I'd like to share with you the best of the week, reviews & research on: Herb of the Week: Genistein Sound Sparkling Tea (product review) Tartary Buckwheat & Autophagy, (research) Licorice & Cancer (research) We're going to review all this and much more on today's #CabralConcept 2268– Enjoy the show and let me know what you thought in the comments! - - - For Everything Mentioned In Today's Show: StephenCabral.com/2268 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!

The first podcast of 2022 discusses two papers with negative outcomes and explores the importance of sharing such results for patients and families and clinicians working with rare disease. Dr Nicoline Løkken discusses her work with resveratrol in mitochondrial myopathies (from 5m 18s) and Dr Arunabha Ghosh and Professor Brian Bigger talk about the use of genistein in Sanfilippo syndrome (from 10m 38s). No effect of resveratrol in patients with mitochondrial myopathy: A cross-over randomized controlled trial Nicoline Løkken, et al https://doi.org/10.1002/jimd.12393 High dose genistein in Sanfilippo syndrome: A randomised controlled trial Arunabha Ghosh, et al https://doi.org/10.1002/jimd.12407

Watch on YouTube - https://youtu.be/bAXz88SPRyo*** Got to practice Epigallocatechin Gallate! Amazing antioxidant showing up in more and more products lately!*** Regimen Lab Skincare Vitamin X Antioxidant Complex Serum Full Ingredients List:Aqua, Propanediol, Ascorbic Acid, Propylene Glycol, Dimethyl Isosorbide, Pentylene Glycol, Acetyl Zingerone, Glycerin, Tocopherol, Epigallocatechin Gallate, Ferulic Acid, Resveratrol, Genistein, Quercetin, Silymarin, Hesperidin Methyl Chalcone, Dimethylmethoxy Chromanol, Xanthan Gum, Lecithin, Sclerotium Gum, Pullulan, Disodium EDTA, Phenoxyethanol, Ethylhexylglycerin, Caprylyl Glycol, Citric Acid ********Sephora - https://fxo.co/1231867/sephoraUlta - https://fxo.co/1231867/ultaAmazon - https://www.amazon.com/shop/nobsbeautyYes Style - https://ys.style/kk2Vjrv798Style Korean - http://www.stylekorean.com/?af_id2=nobsbeautyThese are affiliate links if you purchase anything from one of these stores using this link No BS Beauty will make a small commission on what you buy.********I am proud to offer my very own beauty products at Amazon. We are starting small but hope to grow these offerings. Take a look and if you can pick one or two up, it helps keep this channel truly independent.My Products:No BS Beauty Travel Set - https://amzn.to/2PgPzFZNo BS Beauty Airless Jars - https://bit.ly/2Ev6X6N or https://amzn.to/2RCEq4sNo BS Beauty Color Switcher - https://amzn.to/2RCEAJ6See my own page on Amazon - https://www.amazon.com/shop/nobsbeautywww.noBSbeauty.net*******My Patreon - https://www.patreon.com/noBSbeauty*******PayPal Tip Jar - https://bit.ly/donate_NBSBIf you want to leave a tip ... Thanks! *****Since so many of you asked for it, here is a link to my favorite PH testing strips https://amzn.to/33ojjIY

Anti-aging compound improves muscle glucose metabolism in people Washington University School of Medicine in St. Louis, April 25, 2021 A natural compound previously demonstrated to counteract aspects of aging and improve metabolic health in mice has clinically relevant effects in people, according to new research at Washington University School of Medicine in St. Louis. A small clinical trial of postmenopausal women with prediabetes shows that the compound NMN (nicotinamide mononucleotide) improved the ability of insulin to increase glucose uptake in skeletal muscle, which often is abnormal in people with obesity, prediabetes or Type 2 diabetes. NMN also improved expression of genes that are involved in muscle structure and remodeling. However, the treatment did not lower blood glucose or blood pressure, improve blood lipid profile, increase insulin sensitivity in the liver, reduce fat in the liver or decrease circulating markers of inflammation as seen in mice. The study, published online April 22 in the journal Science, is the first randomized clinical trial to look at the metabolic effects of NMN administration in people. Among the women in the study, 13 received 250 mg of NMN orally every day for 10 weeks, and 12 were given an inactive placebo every day over the same period. "Although our study shows a beneficial effect of NMN in skeletal muscle, it is premature to make any clinical recommendations based on the results from our study," said senior investigator Samuel Klein, MD, the William H. Danforth Professor of Medicine and Nutritional Science and director of the Center for Human Nutrition. "Normally, when a treatment improves insulin sensitivity in skeletal muscle, as is observed with weight loss or some diabetes medications, there also are related improvements in other markers of metabolic health, which we did not detect in our study participants." The remarkable beneficial effects of NMN in rodents have led several companies in Japan, China and in the U.S. to market the compound as a dietary supplement or a neutraceutical. The U.S. Food and Drug Administration is not authorized to review dietary supplement products for safety and effectiveness before they are marketed, and many people in the U.S. and around the world now take NMN despite the lack of evidence to show clinical benefits in people. The researchers studied 25 postmenopausal women who had prediabetes, meaning they had higher than normal blood sugar levels, but the levels were not high enough to be diagnosed as having diabetes. Women were enrolled in this trial because mouse studies showed NMN had the greatest effects in female mice. NMN is involved in producing an important compound in all cells, called nicotinamide adenine dinucleotide (NAD). NAD plays a vital role in keeping animals healthy. Levels of NAD decline with age in a broad range of animals, including humans, and the compound has been shown to contribute to a variety of aging-associated problems, including insulin resistance in studies conducted in mice. Supplementing animals with NMN slows and ameliorates age-related decline in the function of many tissues in the body. Co-investigator Shin-ichiro Imai, MD, Ph.D., a professor of developmental biology and of medicine who has been studying NMN for almost two decades and first reported on its benefits in mice said, "This is one step toward the development of an anti-aging intervention, though more research is needed to fully understand the cellular mechanisms responsible for the effects observed in skeletal muscle in people." Insulin enhances glucose uptake and storage in muscle, so people who are resistant to insulin are at increased risk for developing Type 2 diabetes. But the researchers caution that more studies are needed to determine whether NMN has beneficial effects in the prevention or management of prediabetes or diabetes in people. Klein and Imai are continuing to evaluate NMN in another trial involving men as well as women.   High dose of vitamin D fails to improve condition of moderate to severe COVID-19 patients   University of São Paulo's Medical School (Brazil), April 26, 2021 Can a high dose of vitamin D administered on admission to hospital improve the condition of patients with moderate or severe COVID-19? The answer is no, according to a Brazilian study published in the Journal of the American Medical Association (JAMA). The article reports a randomized, double-blind, placebo-controlled clinical trial, the kind of study considered the gold standard to evaluate drug efficacy. It was conducted with FAPESP's support by researchers at the University of São Paulo's Medical School (FM-USP), who recruited 240 patients treated at Hospital das Clínicas (HC), the hospitalcomplex run by FM-USP, and the Ibirapuera field hospital in São Paulo City in June-August 2020. "In vitro studies or trials with animals had previously shown that in certain situations vitamin D and its metabolites can have anti-inflammatory and anti-microbial effects, as well as modulating the immune response. We decided to investigate whether a high dose of the substance could have a protective effect in the context of an acute viral infection, reducing either the inflammation or the viral load," Rosa Pereira, principal investigator for the project, told Agência FAPESP. The volunteers were randomly divided into two groups, one of which was given vitamin D3 in a single dose of 200,000 units (IU) dissolved in a peanut oil solution. The other group was given only the peanut oil solution. All participants were treated according to the standard protocol for hospital treatment of the disease, which includes administration of antibiotics and anti-inflammatory drugs. The main purpose was to see if acute supplementation would affect the length of hospital stay for these patients, but the researchers also wanted to find out whether it would mitigate the risks of admission to the intensive care unit (ICU), intubation and death. No significant difference between the groups was observed for any of these clinical outcomes. According to Pereira, the study was designed above all to assess the impact on hospital stay and a larger number of volunteers would be needed to achieve a scientifically acceptable estimate of the effect on mortality. "So far we can say there's no indication to administer vitamin D to patients who come to the hospital with severe COVID-19," she said. For Bruno Gualano, a researcher at FM-USP and penultimate author of the article, the findings show that at least for now there is no "silver bullet" for the treatment of COVID-19. "But that doesn't mean continuous use of vitamin D can't have beneficial effects of some kind," he said. Ideal dose Pereira is currently leading a study at FM-USP to find out whether subjects with sufficient circulating levels of vitamin D combat infection by SARS-CoV-2 better than those with insufficient levels of the nutrient. The ideal level of vitamin D in the blood and the daily supplementation dose vary according to age and overall health, she explained. Older people and patients with chronic diseases including osteoporosis should have more than 30 nanograms per milliliter of blood (ng/mL). For healthy adults, 20 ng/mL is an acceptable threshold. "The ideal approach is case-by-case analysis, if necessary dosing the substance periodically by means of blood work, with supplementation if a deficiency is detected," Pereira said.         Sufficient serum vitamin D before 20 weeks of pregnancy reduced risk of gestational diabetes mellitus Fudan University Obstetrics and Gynecology Hospital (China), April 16, 2021 A new study on Nutritional and Metabolic Diseases and Conditions - Obesity and Diabetes is now available. According to news originating from Shanghai, People’s Republic of China, by NewsRx correspondents, research stated, “Our aim was to evaluate the relationship between serum vitamin D levels before 20 weeks of pregnancy and the risk of gestational diabetes mellitus. This study is a retrospective study.” Our news journalists obtained a quote from the research from Fudan University Obstetrics and Gynecology Hospital, “We analyzed the relationship between serum 25 (OH) D level before 20 weeks of pregnancy (first antenatal examination) and the risk of gestational diabetes mellitus. Age, parity and pre-pregnancy body mass index were used as confounding factors. 8468 pregnant women were enrolled in this study between January 2018 and March 2020 at the Obstetrics and Gynecology Hospital of Fudan University. Adjusted smoothing splinespline plots, subgroup analysis and multivariate logistic regression analysis was conducted to estimate the relative risk between 25(OH)D and gestational diabetes mellitus. After fully adjusting the confounding factors, serum vitamin D is a protective factor in gestational diabetes mellitus (OR=0.90). Compared with vitamin D deficiency, vitamin D insufficiency (OR=0.78), sufficience (OR=0.82) are a protective factor for gestational diabetes mellitus. Sufficience vitamin D before 20 weeks of pregnancy is a protective factor for gestational diabetes mellitus. Vitamin D>20 ng/mL can reduce the risk of GDM, which is not much different from the effect of >30 ng/mL.” According to the news editors, the research concluded: “The protective effect of vitamin D is more significant in obese pregnant women.”     Review summarizes known links between endocrine disruptors and breast cancer risk University of Eastern Finland, April 20, 2021 Exposure to certain endocrine-disrupting chemicals could elevate the risk of breast cancer, according to a new comprehensive systematic review of epidemiological research. However, for many chemicals, evidence is inconsistent or still limited. The review was carried out by researchers at the universities of Hong Kong and Eastern Finland and published in Critical Reviews in Food Science and Nutrition. Endocrine-disrupting chemicals (EDCs) can interfere with the body's hormonal system, also called the endocrine system, and are widely present in the environment. They originate from a variety of sources, including pesticides, plasticisers and other industrial and pharmaceutical chemicals, as well as natural sources. Humans are often exposed to EDCs through food, but other possible exposure routes include drinking water, skin contact and air. Breast cancer accounts for the majority of women's cancers. There has been an increasing interest in the role of estrogene-mimicking EDCs, so called xenoestrogens, in the development of breast cancer. They comprise a broad range of pesticides, synthetic chemicals, phytoestrogens and certain mycotoxins. The researchers reviewed 131 epidemiological studies evaluating the link between xenoestrogen exposure and breast cancer. Most studies assessed exposures by measuring the EDCs and their metabolites in urine, serum, plasma or adipose tissues.  Some may be genetically more vulnerable to EDCs According to the review, the nowadays widely banned pesticide DDT is one of the most studied EDCs in relation to breast cancer risk. Out of 43 epidemiological studies, eleven reported positive associations between DDT or its metabolites in lipid, serum or plasma and breast cancer incidence. Nine reported higher DDT levels among women with breast cancer than among controls. In a few studies, DDT was linked to estrogen-positive breast cancer or the association to breast cancer risk depended on genotype.  Polychlorinated biphenyls, PCBs, are a large group of compounds earlier much used in electrical devices, surface coatings and other purposes. The review of 50 studies found the association between total PCBs and breast cancer risk to be inconsistent. However, 19 studies linked certain PCBs to a higher breast cancer incidence. Similar to DTT, PCBs accumulate in the adipose tissue and in the food chain and can be excreted in breast milk.  Perfluorooctanoid acid (PFOA) found in some food packaging and cookware was linked to breast cancer risk in three out of five epidemiological studies. Some studies found an association between cancer risk and certain genotypes both for PCBs and PFOAs. DDT, PCBs ja PFOA are POP substances, persistent organic pollutants, the use of which is strictly regulated. DDT ja PCBs are old POP substances and their levels in the environment are decreasing. PFOA is a newer POP substance. Phytoestrogens were found beneficial in some, but not all studies Phytoestrogens are natural plant estrogens that have been suggested to prevent breast cancer. Genistein is a phytoestrogen found in soy products. The review included 29 epidemiological studies focusing on genistein, 18 of which linked it to a lower breast cancer risk, although some only in certain age groups or populations. For most EDCs included in the review, the link to breast cancer has been investigated in only a few epidemiological studies. Phtalates and bisphenol A (BPA), for example, are used in plastic packaging and can transfer to food. According to the review, four out of six studies linked phthalates to increased breast cancer risk. BPA was linked to more aggressive tumours in one study, but two other epidemiological studies found no link to breast cancer. Parabens are common preservatives in foods and cosmetic products and considered possible endocrine disruptors. The only epidemiological study on the topic reported a link between paraben exposures, breast cancer risk and mortality following breast cancer.  Oral contraceptive use was linked to an increased breast cancer risk in seven out of eight epidemiological studies, but there were controversies on how duration or discontinuation of oral contraceptive use affected the risk. The review also included the herbicide atrazine, the industrial by-product dioxine, mycotoxins produced by food and crop molds, and PBDEs found in household furniture coatings and appliances, but epidemiological studies on their links to breast cancer risk were still scarce and often inconsistent.  The writers point out that for EDCs to disrupt endocrine functions, dose, time, duration and age at exposure all matter. In addition, as multiple EDCs coexist in the environment, more research is needed to evaluate their interactive effects on breast cancer risk. The review also suggests that genotypes could determine whether EDC exposure affects breast cancer risk, and more research is needed on this topic. "One example is the polymorphism of the CYP1A1 gene, which is responsible for estrogen metabolism." According to the writers, next-generation technologies, such as genome sequencing, proteomics or epigenomics, can help identify new exposure biomarkers with better sensitivity and specificity. "These technologies will also pave way to better assessment of past exposure and prediction of future risks, by taking into account an individual's genetic profile."     Grape seed extract may protect gut from inflammation: Study Universitat Rovira i Virgili (Spain), April 25, 2021 Proanthocyanidin-rich grape seed extracts may protect the intestines from the deleterious effects of a high-fat/high-carbohydrate diet, according to data from a rat study. A high-fat/high-carbohydrate diet or Western diet has been reported to produce changes in the intestine, explained researchers from the Universitat Rovira i Virgili in Tarragona, Spain. “Concretely, several recent studies have provided compelling new evidence to suggest that changes in the epithelial barrier function and intestinal inflammation are associated with and could even lead to altered regulation of body weight and glucose homeostasis,” they added. “The main consequence of the gut barrier dysfunction has been proposed to be the entry of toxins from the intestinal lumen, which can trigger local inflammation or gain access to the circulation and induce systemic inflammation through cytokine release.” Their new research indicated that a grape seed proanthocyanidin extract (GSPE) may protect the gut from such harmful effects. Study details Data published in Molecular Nutrition and Food Research reveals that supplementing the diet of lab rats with medium or high-dose proanthocyanidins had beneficial impacts on intestinal inflammation, oxidative stress, and barrier function. The medium dose was 25 mg/kg, which is a dose similar to the dietary proanthocyanidin intake in humans, explained the researchers. The high dose (50 mg/kg) would exceed the dietary proanthocyanidin intake in humans. Thirty-six week-old rats were fed a Western diet for 15 weeks and then divided into one of four supplementation groups, receiving 0 mg/kg (control), 5 mg/kg (low dose), 25 mg/kg, or 50 mg/kg for an additional three weeks. Results showed that intestinal inflammation, assessed by measuring myeloperoxidase (MPO) activity, significantly increased in the control animals, but these increases were reduced in the rats receiving the grape seed extract. In addition, significant reductions in plasma levels of reactive oxygen species were observed in the medium and high dose groups, compared to the control group. Tight junctions The researchers also examined the function of the intestinal barrier, and looked specifically at so-called tight junctions (TJ) between cells in the lining of the intestine – the epithelium. On one side is the intestinal cavity and on the other is a mass of cells and tissues. In a healthy system, materials in the cavity find their way into tissues by passing through the cells, which controls which substances pass through. In an unhealthy system, the tight junctions are not so tight and materials can bypass the cells and find their way into tissues via the tight junctions. This increase in intestinal permeability has been referred to as "leaky gut". “Another point of interest in this study was to evaluate whether GSPE could modulate the alterations in the permeability of the intestinal barrier that are related to the state of intestinal inflammation,” wrote the researchers. “Our findings indicate that the TJ  proteins were negatively associated with measures of adiposity and with the circulating levels of [triglycerides]. These are not causal associations, but they suggest that increased adiposity is accompanied by lower expression of TJ components, which is in agreement with the hypothesis that obesity and a [high-fat diet] are associated with increased intestinal permeability. Then, given the importance of having a healthy barrier function, dietary interventions that can modulate the intestinal permeability might afford an effective tool for the prevention and treatment of metabolic diseases associated with obesity.” The researchers concluded: “Our findings indicate that orally administered GSPE modulates the intestinal inflammation, oxidative stress, and possibly the barrier function. Based on these findings, our data suggest that nutritional and/or therapeutic interventions focused on gut health and modulation of the intestinal permeability should be extensively explored in the context of obesity.”   Antidepressant use in pregnancy tied to affective disorders in offspring; no causal link   Mount Sinai Hospital, April 12, 2021 Major depressive disorder is highly prevalent, with one in five people experiencing an episode at some point in their life, and is almost twice as common in women than in men. Antidepressants are usually given as a first-line treatment, including during pregnancy, either to prevent the recurrence of depression, or as acute treatment in newly depressed patients. Antidepressant use during pregnancy is widespread and since antidepressants cross the placenta and the blood-brain barrier, concern exists about potential long-term effects of intrauterine antidepressant exposure in the unborn child.  Using the Danish National Registers to follow more than 42,000 singleton babies born during 1998-2011 for up to 18 years, researchers at the Icahn School of Medicine at Mount Sinai investigated whether exposure to antidepressants in the womb would increase the risk of developing affective disorder like depression and anxiety in the child. In a study published April 5 in Neuropsychopharmacology,the scientists found that children whose mothers continued antidepressants during pregnancy had a higher risk of affective disorders than children whose mothers stopped taking antidepressants before pregnancy. However, to understand whether the underlying disorder for which the antidepressant was given or the medication itself was linked to the child's risk of developing an affective disorder, they also studied the effect of paternal antidepressant use during pregnancy and similarly, found that children of fathers who took antidepressants throughout pregnancy had a higher risk for affective disorders. Thus, the research team speculates that rather than being an intrauterine effect, the observed link is most likely due to the parental mental illness underlying the antidepressant use.  "Approximately half of women who use antidepressants before pregnancy decide to discontinue use either before or during pregnancy due to concerns about the negative consequences for their child," said Anna-Sophie Romel, PhD, an instructor in the Department of Psychiatry at Icahn Mount Sinai and first author of the paper. "Our study does not provide evidence for a causal relationship between in-utero exposure to antidepressants and affective disorders in the child. So, while other long-term effects of intrauterine exposure to antidepressants remain to be investigated, our work supports antidepressant continuation for women with severe symptoms or a high risk of relapse because untreated psychiatric illness during pregnancy can have negative consequences on the health and development of the child. Women and their health care providers should carefully weigh all of the treatment options and jointly decide on the best course of action."   Staying Active Can Fight Declines in Cognitive Engagement   North Carolina State University, April 22, 2021   Preserving physical and mental health helps older adults experiencing cognitive impairment stave off declines in cognitive engagement, a new study suggests “We found that declines in physical and mental health were associated with more pronounced cognitive disengagement,” says Shevaun Neupert, professor of psychology at North Carolina State University and corresponding author of the study published in Entropy. “The impact of declines in physical health was particularly pronounced for study participants who had more advanced cognitive impairment to begin with.” There’s a lot of research showing that cognitive engagement can help older adults maintain cognitive health. However, the vast majority of that work has been done on healthy adults. “There’s very little work on cognitive engagement in people who are already cognitively impaired, such as people who have been diagnosed with dementia,” Neupert says. “Are they still capable of sustained cognitive engagement? What factors contribute to that engagement?” To begin addressing those questions, the researchers enlisted 28 study participants. All of the participants were over 60 and had documented cognitive impairment. Participants came to a testing site two times, six months apart. On each visit, researchers collected data on the physical and mental health of the study participants and performed a battery of tests designed to assess cognitive ability. They also connected participants to a device that tracked blood pressure continuously and then asked them to engage in a series of increasingly difficult cognitive tasks. This allowed researchers to track how cognitive engagement changed as the tasks become progressively harder. Cognitive engagement means taking part in activities that are mentally challenging. Monitoring blood pressure allows the researchers to track how hard study participants are working to accomplish cognitive tasks. Specifically, blood pressure rises as more blood is pumped to the brain when participants work harder at these tasks. Broadly speaking, the researchers found that if a participant’s cognitive ability, physical health, or mental health declined over the course of the six month study period, that participant became less cognitively engaged as the tasks became harder. “Normally, you’d expect more engagement as the tasks became harder, but we found that some people essentially stopped trying,” says coauthor Claire Growney, a postdoctoral researcher at Washington University in St. Louis. “The findings highlight the fact that well-being is holistic; physical health, mental health, and cognitive function can influence each other,” says coauthor Xianghe Zhu, a recent PhD graduate of NC State. “In practical terms, it suggests that it may be particularly important for people to focus on mental and physical well-being during the early stages of cognitive decline,” Growney says. “Or, at the very least, don’t become so focused on addressing cognitive challenges that you ignore physical health, or create anxiety or emotional distress for yourself that leads to mental health problems.” “Future research will be needed to determine how beneficial it might be for people to take part in cognitively engaging activities once they’ve started experiencing cognitive decline,” Neupert says. “But we already know that there is an element of ‘use it or lose it’ to cognitive function in healthy adults. And while it’s understandable for people to want to avoid tasks that are difficult or challenging, it’s really important to continue challenging ourselves to take part in difficult cognitive activities.”

Dwight McKee, MD, is board-certified in medical oncology, hematology, nutrition, and integrative and holistic medicine. He discusses his lifetime of experience in the cancer world with Dr. Moss. For more information about Moss Reports, visit mossreports.com  There are at present no drugs approved specifically to kill [Cancer Stem Cell]s. But, starting around 2015, scientists identified about two dozen natural agents (from foods and herbs) that killed CSCs. Of these, five stand out. Drs. Dwight McKee and Cord Naujokat have called these the “Big Five”:   Curcumin is derived from the root stem (rhizome) of the turmeric plant. There are over 5,700+ articles on the topic of curcumin and cancer in  PubMed, the U.S. government's index of medical journal entries, with new ones appears at a rate of twice every calendar day. Genistein and other Isoflavones from soybeans and soy products, as well as red clover, and coffee (over 4,712 PubMed articles) Resveratrol from red grapes skins, plums, berries (3,654 articles) EGCG (Epigallocatechin-3-gallate), the main solid ingredient in green tea (1,872 PubMed articles) Sulforaphane and isothiocyanates from cruciferous vegetables such as broccoli and broccoli sprouts (1,085 articles)   These “Big Five” are the subject of around 17,000 scientific journal articles relating to cancer. This refutes the notion that such treatments are a fringe phenomenon.   According to McKee and Naujokat's article in the February 27, 2020, Current Medicinal Chemistry:   “Since current cancer therapies fail to eradicate CSCs, leading to cancer recurrence and progression, targeting of CSCs with phytochemicals such as curcumin, EGCG, sulforaphane, resveratrol and genistein…may offer a novel therapeutic strategy against cancer.” (14)    

Paleo MRE, Anxiety and College Food, Keto after Pancreatitis, Metabolically Flexible?, Thoughts on Genistein from Soy. Make your health an act of rebellion and join the community here. Please Subscribe and Review: Apple Podcasts | RSS This episode of The Healthy Rebellion Radio is sponsored by Perfect Keto. Perfect Keto makes eating keto easier. Perfect Keto provides clean low-carb bars, nut butters, and supplements, and the best keto recipes and info so you can keto with confidence. Go to http://perfectketo.com/rebellion10 and use code REBELLION10 for $10 off orders of $40 or more  Download a copy of the transcript here (PDF) Watch the podcast video here   Show Notes: News topic du jour: Red Meat and CVD https://annals.org/aim/fullarticle/2752320/red-processed-meat-consumption-risk-all-cause-mortality-cardiometabolic-outcomes?   1. Paleo MRE [18:18] Matt says: I’ve been in the military for about five years now.  I joined later in life and after I was introduced to paleo/keto/low carb.  Let me tell you, the DOD approach to nutrition is pretty bad.  Outside of some interesting studies they are pursuing, they still stick to the standard info we are used to hearing of low fat, high carb, chocolate milk for recovery, gatorade to rehydrate (we were force fed gatorade at the last school I went to in San Antonio, I would put LMNT in my water and a tiny bit of gatorade powder just to change the water's color).  With the ever increasing number of product lines that exist that cater to a paleo/ low carb/real food crowd, could there ever come a time when a paleo MRE product could be developed that would be low cost enough to compete for a government contract with the trash that's out there now?  MRE's are full of sugar and food with a long shelf life that have some serious GI consequences that, let's just say, take an individual from one extreme to the other when it comes to bathroom utilization.  The beverage powders are just plain gatorade, the fat sources are usually peanuts, the protein is nearly non-existent, and the "energy bars" are incredibly high glycemic.  About an hour after consuming one, most people just want to put a diaper on and take a long nap.  I know there are several paleo MRE's available commercially, but in my experience they don't address the caloric needs of a soldier in the field and consist primarily of jerky, nuts, and dried fruit.  When you look at a cost to calorie ratio they don't really pan out too well.      2. Anxiety, College student food [22:52] Cole says: Hey Robb and Nicki, Recently I have been struggling with stress and anxiety. It started about 4 months when I was preparing and being interviewed for a job which was very stressful.  A random thought ended up becoming an unwanted intrusive thought which caused lots of debilitating distress, stress and anxiety. I ended up loosing about 10 pounds unintentionally. Begun getting the chills and shivering in the mornings. Loss my appetite. I am still struggling with the chills and shivers in the morning but my anxiety and stress levels have dropped. My mind had also gotten more clear. I’m not gonna lie...during the time this happened I was not eating too well. About 3 years ago I lost 100 pounds with a non paleo low carb approach, that was cleanish. I have maintained it since then. My 21st birthday was around this time and I did drink quite a bit but I have limited usage to once a week. I like paleo. I cleaned up my diet quite a bit and I feel it has made a difference. Should I stick with paleo, go low carb or even keto. Thank you for your help and please let me know what you think! Best, Cole   3. Ketogenic diet after having had an attack of pancreatitis [28:25] Anil says: Have implemented the PKD diet but have been struggling with the 2:1 animal fat to protein ratio. Prior to this I was on the classic keto diet and also struggled with animal fats (fatty cuts of meat, bone marrow for e.g) but never had a problem with avocados, nuts or raw milk fatty cheese. Have had an attack of pancreatitis 4 years ago also became a diabetic but reversed all that naturally via the keto diet, but still struggle with gut issues. Could this be linked to the attack of pancreatitis? if so why just animal fat and not other fats? Also did my fecal elastase test, fat in stools etc which were normal. Also a CT scan of pancreas did not show any abnormality....so what gives?   4. Am I Metabolically Flexible? [34:43] @ketoKJ says: Question! low carb/keto for 2 years, if I indulge in a HCHF treat I expect to feel horrible & I don't, does that mean I am Metabolically flexible or still insulin resistant? So I had a fried pie with ice cream. A special place we stop in Georgia. And I eat meat heavy low carb and always surprise I don't feel the discomfort most talk about, no bloat, headache, stomach ache kind of wish I did.   5. Interested in hearing your thoughts on this.... (Genistein, Soy) [37:17] Shannon says My name is Shannon, and I have one of your books (wanting to buy more!), and LOVE your podcast...such GREAT INFO. Anyways, I got an email from "GreenMedInfo Newsletter" and one of the articles was talking about the health benefits of a nutrient found in Soy to help with Bone Density.  Everything I have read, and understood about soy (IMO overall) is NOT GOOD...I'm curious to know your thoughts on this article- because I assume people, women especially, will be running to the store to buy this to "Increase Bone Density."  I'd love to hear you go into this on one of your podcasts!  See link to the article below https://www.greenmedinfo.health/blog/genistein-soy-nutrient-puts-bone-drugs-shame Thank you for your time, and keep up the great work! Shannon Connors  

A first for the Anti-cancer Revolution Podcast… We put the spotlight on one of my favourite anti-cancer products, Haelan 951. I chat to Jordan Todesco, son of Lesly Todesco who founded Haelan Products in 1990.   Jordan’s brother Jared is good friend of mine from high school, and the first person I called after Ryder was diagnosed. Jared got us onto Haelan 951 right away and also introduced Teddy and I to a number of natural healers and integrative practitioners which kick-started the path we’re on today.   ***Resources Mentioned***   Haelan 951 website (10% discount available to listeners - use the promo code STERN at checkout) PubMed Studies on genistein  RGCC test Colon cancer and saponins Pancreatic carcinoma study FSWW08 studies Greens First Calibr8    *** In This Episode: In this first of its kind product deep dive, I speak with Jordan about the anti-cancer compounds of Haelan 951 and what makes this product so unique. We also delve into some of the published studies about the beneficial effects of Haelan 951 on people going through cancer.   I’d love to hear what you think of this one so feel free to leave a comment below.    What does Haelan mean? Healing in Old English   Where did Healan 951 originate from? Originally from China  Jordan’s father came across it in 1985  With the help top scientists he improved the formulation to what it is today   What is Healin 951?  A fermented soy beverage Powerful food - immunonutrition  Not all soy is created equal, there are over 2500 species of soy Haelan 951 uses organic, non-GMO soy grown in Mongolia above 3300ft elevation to eliminate cross pollination Multi-stage fermentation process  25lb of whole soy beans into an 8oz serving Packed with anti-cancer compounds such as Isoflavones like genistein and daidzin, and protease inhibitors Highly bioavailable   What does genistein do? Incredible studies on this compound in PubMed Genistein can down-regulate the N-Myc gene (a gene that can compromise survival rates in some children with Neuroblastoma)  Use search engines like Yahoo or Bing as Google censor alternative health search results A hormone-like substance Inhibits initialization of cellular pathways that lead to cancer  Stops notch signaling (regulation of immunity and inflammation in the body)   Why is Haelan 951 better than other genistein supplements on the market? 5 compounds within the specific strain of soy bean work together synergistically Often the RGCC test recommends genistein  More genistein per serving  Bioavailabilty is second to none Out bodies only absorb 39-53% of supplements in capsule form. A lot of capsule content can be filler Pure form of genistein, not synthetic. 99% purity rate, nearest competitor is around 91% purity Very specific strain of soy bean   Protease inhibitors Prevent synthesis of key proteins required for cancer cells to spread such as the the Bowman-Berk inhibitor that has a suppressive effect on cancer cells   Saponins Latin word for soap  Plant steroid that foams when mixed with water Within our bodies: Induce apoptosis (death) of cancer cells Fight free radicals Improve immune function Block signalling pathways that lead to cancer Particularly effective for colon cancer   Phytosterols Similar to cholesterol Lowers risk of heart disease Improves blood flow - critical for healing and in spreading nutrients around the body   Amino acids Loaded with essential and branch chain amino acids   The soy / estrogen debate Phytoestrogens (plant estrogen) are weaker estrogen Received by the cell and ‘fills’ it up Some cancers are estrogen driven so blocking this power source is good  Breast cancer patients who consume flaxseeds have seen reduced recurrence  The ‘aggressive’ estrogen comes from things like plastics and toxins in skin care  Haelan 951 comes in a glass bottle for this reason   Studies on Haelan 951 Induces growth arrest and apoptosis in pancreatic carcinoma  Classified by FDA as a food FSWW08 was used as a term for Haelan 951 in blind or double-blind studies Used by athletes Study shows improvements in PTSD - balance hormonal issues with phytoestrogens Benefits seen in hematology and cachexia (side effect of chemo) Breast cancer studies ALS studies   Is Haelan 951 covered by insurance? Covered by some insurance companies  Need to file for reimbursement after purchasing the product Haelan reps can help with questions Follow steps to file for reimbursement - obtain a letter of medical necessity and a treatment authorisation request  Need to have Medicare supplemental insurance    The smell and taste A very potent taste and smell Recommend mixing it with Greens First, Calibr8 or chocolate flavoured stevia   Contaminant testing Tests for herbicides, pesticides, heavy metals done at the factory and in the US Commitment to and reputation for quality Well known in the integrative world amongst Doctors and Practitioners How to get Healan 951 Visit the website PH: 425 482 4625 10% discount available to listeners - use the promo code STERN at checkout Blog Facebook LinkedIn If you have a question or comment about this episode please let us know below!!

Can Genistein Help Heal Hashimoto’s Disease and Hypothyroidism? In the fall of 2016, a study was conducted in China and published in the medical journal Immunobiology. The researchers looked at the compound genistein and Hashimoto's disease to see if it affected thyroid function in patients with Hashimoto’s thyroiditis.  The research paper was entitled, “Genistein improves thyroid function in Hashimoto’s thyroiditis patients through regulating Th1 cytokines.”  To clarify, “Th1 cytokines” refer to a type of thyroid-helper cells that indicate how much inflammation there might be in the thyroid gland.  In other words, they are markers of inflammation. The results of this study were very exciting so you might want to pay close attention. What is genistein? Genistein is an isoflavone which is a plant-derived compound with estrogenic activity.  It falls in the class of phytoestrogens and is found in soybeans.  Clinical studies in the past have demonstrated that this compound has immune-regulating properties by exerting anti-inflammatory effects in certain health conditions including encephalomyelitis (inflammation of the brain and spinal cord), cardiac inflammation resulting from diabetes, coronary obstructive pulmonary disease (COPD) and other serious diseases. In this study, Zhang and four of his colleagues began by pointing out that Hashimoto’s thyroiditis is now considered the most common autoimmune disease in the world.  It is believed that excessively stimulated thyroid-helper cells play the main role in giving rise to the autoimmune condition in Hashimoto’s thyroiditis patients.  While conventional treatment has typically addressed only the symptoms of the illness via oral administration of a thyroid hormone replacement, the fact remains that there is still an autoimmune condition in Hashimoto’s thyroiditis which can be a concern. Why is it problematic for an autoimmune condition to persist in an individual with Hashimoto’s disease? Previous studies have demonstrated that in those with fully or partially functional thyroid glands but not “fully hypothyroid Hashimoto’s patients”, long-term Hashimoto’s thyroiditis closely correlated with the prevalence of thyroid cancer. Chronic inflammation is never beneficial for the body so if someone is invested in his or her health, mitigating any autoimmune condition would be prudent.  In this investigation, the researchers wanted to evaluate any beneficial anti-inflammatory properties of genistein for those with Hashimoto’s thyroiditis and examine what impact it might have on the chronic inflammatory condition associated with Hashimoto’s disease. How was the study done? Two-hundred eighteen female subjects between the ages of 20 and 80 were recruited, all with Hashimoto’s thyroiditis. These requirements had to be met in the subjects: 1. Normal levels of free T3 and free T4 with or without thyroid replacement therapy 2. Normal TSH levels or slightly elevated TSH levels below 20 mU/L 3. Increased blood levels of thyroid antibody (thyroid peroxidase) greater than 100 U/mL Subjects with any of the following conditions were excluded: 1. Prior use of immunoregulators 2. Presence of infection 3. Presence of thyroid nodules 4. Thyroid hypoplasia 5. Prior treatment with radioiodine 6. Pregnancy 7. Presence of serious illnesses such as cancer, kidney or liver failure. The 278 females with Hashimoto’s were split into two groups with 143 in the placebo group and 135 in the genistein group.  Patients in the genistein group were given 600 mg per day of genistein as a purified soy extract taken orally for thirty days. What lab work was required? To measure thyroid function: 1. TSH 2. T3 3. T4  (total T4) 4. fT4 (free T4) To measure thyroid antibody levels: 1. Thyroid peroxidase - TPOAb 2. Thyroglobulin – TgAb To measure inflammation: Thyroid-helper cell bodies (Th1 and Th2) which we will refer to henceforth as inflammatory markers.

Ziel dieser Arbeit war die Untersuchung des Einflusses verschiedener Naturstoffe auf die Expression und Aktivität des menschlichen eNOS Proteins in endothelialen Zellen. Zum einen wurde untersucht, ob die Sojaisoflavone Formononetin, Biochanin A, Genistein und Daidzein die Expression und Substartumsatz der eNOS erhöhen können. Zum anderen wurde die Wirkung einer großen Anzahl von Rotweinpolyphenolextrakten auf die eNOS Expression und Enzymaktivität untersucht. Damit sollte die Frage geklärt werden, ob Anbaugebiet, Rebsorte und Vinifikationsprozeß das Ausmaß der Steigerung von eNOS Expression und Aktivität durch Rotweinpolyphenolextrakte beeinflussen und ein Hinweis auf wirksamkeitsbastimmende Substanzen erhalten werden. Das Sojaisoflavon Genistein erhöht die eNOS Enzym Aktivität und die eNOS vermittelte NO Produktion nach 48-96 h Stimulation. Diese Effekte sind durch den Estrogen Rezeptor Antagonisten ICI 182,780 nicht hemmbar. Durch den Vergleich einer großen Anzahl Rotweinpolyphenolextrakte aus verschiedenen Rotweinen konnte in dieser Arbeit gezeigt werden, daß Rebsorte und Anbaugebiet einen Einfluß auf das Ausmaß der Wirkung von Rotwein auf die Expression des eNOS Gens haben. Weißweinpolyphenolextrakte steigern in vergleichbarem Maß die Aktivität des eNOS Promotors. Aus der unterschiedlichen Zusammensatzung von wirksamen und weniger wirksamen Rotweinpolyphenolextrakten und Weißweinpolyphenolextrakten könnten künftig Rückschlüsse auf die wirksamkeitsbestimmenden Inhaltsstoffe gezogen werden. Bereits in den Trauben liegen Substanzen vor, die die eNOS Expression verstärken. Der Vinifikationsprozeß scheint die Aktivität jedoch weiter zu steigern. Für den Rotweininhaltsstoff Resveratrol konnte ein Effekt auf die eNOS Expression nachgewiesen werden. Resveratrol steigerte die eNOS Expression jedoch erst in höheren Konzentrationen, als bei der Stimulation endothelialer Zellen mit RWPE erreicht werden konnten. Resveratrol scheidet somit als alleiniger Stimulus der eNOS Expression aus. Zusammen mit anderen Inhaltstoffen kann es aber möglicherweise essentiell zum Gesamteffekt beitragen. Mit dem Beginn der Evaluierung von Einsatzmöglichkeiten der CARS Mikroskopie zur Detektion biologisch interessanter Moleküle, insbesondere von NO, in lebenden Zellen wurde ein grundlegender Beitrag zur Erweiterung der Methodenpalette innerhalb der biomedizinischen Forschung geleistet.

Reaktive – Sauerstoff - Spezies (ROS) spielen in der Physiologie und Pathophysiologie des vaskulären Systems eine wichtige Rolle. So kommt es z.B. bei Hypertonie, Atherosklerose, Ischämie / Reperfusion und weiteren Krankheiten und Stoffwechselstörungen, wie z.B. Hypercholesterinämie und Diabetes mellitus zu einem Ungleichgewicht zwischen Sauerstoffradikalbildung und anti - oxidativen Mechanismen. Superoxidanionen (O2 -) spielen insofern eine besondere Rolle, als sie durch direkte Interaktion endotheliales NO inaktivieren, so daß es seine vasodilatatorische, anti – proliferative und plättchenaggregationshemmende Funktion nicht mehr voll erfüllen kann. Damit ist O2 - maßgeblich an der Induktion der Endotheldysfunktion beteiligt. Bei Beginn dieser Arbeit gab es erste Hinweise, daß eine der leukozytären NAD(P)H - Oxidase ähnlichen Oxidase auch im Endothel existiert und wesentlich zur endothelialen O2 - - Bildung beiträgt. Wenig erforscht waren jedoch die Regulationsmechanismen dieser Oxidase. Ein bisher noch nicht bekannter Stimulus zur Steigerung der endothelialen O2 - - Bildung wurde 1996 beschrieben. In Endothelzellen aus bovinen Pulmonararterien führte eine Depolarisation zu einer gesteigerten O2 - - Bildung. Dies kann insofern von Bedeutung sein, als es sowohl unter physiologischen, als auch pathophysiologischen Bedingungen zu akuten oder chronischen Veränderungen des endothelialen Membranpotentials kommt. In dieser Arbeit wurde nun untersucht, ob eine NAD(P)H – Oxidase in der Tat auch in humanen Endothelzellen vorhanden ist, ob sie im Gegensatz zur leukozytären Form konstitutiv aktiv ist, und welchen Beitrag sie zur basalen endothelialen O2 - - Bildung leistet. Weitere Untersuchungen in HUVEC sollten zeigen, ob und wie sich sowohl De – als auch Hyperpolarisation der Zellmembran auf die O2 - - Bildung auswirken, welches Enzym hierbei eine Rolle spielt und welche Signaltransduktionsmechanismen beteiligt sind. Zur O2 - - Messung an vaskulären Zellen war die Verwendung der Lucigenin – Chemilumineszenz – Methode etabliert, so daß auch hier anfänglich mit dieser Methode gearbeitet wurde. Da jedoch dann Befunde veröffentlicht wurden, die zeigten, daß Lucigenin in Enzymsyste-men, die sonst kein oder nur wenig O2 - produzieren, zu einer erheblichen O2 - - Bildung führte, mußte mit weiteren Methoden der O2 - - Messung überprüft werden, ob diese Nachteile auch unter unseren Versuchsbedingungen auftraten. Verwendet wurden hierzu die MCLA – verstärkte Chemilumineszenz, die NBT – und Cytochrom C – Methode. Mit diesen verschiedenen, voneinander unabhängigen Methoden zeigte sich, daß in Anwesenheit von NADH Lucigenin selbst zu einer wesentlich gesteigerten O2 - - Bildung in Lysaten von humanen Umbilikalvenenendothelzellen (HUVEC) führt. Daher wurde zur Untersuchung der endothelialen O2 - - Bildung in dieser Arbeit schließlich nur die Cytochrom C Methode verwendet. Zur Überprüfung der Auswirkungen der verwendeten Substanzen auf das Membranpotential wurde die Membranpotentialmeßmethode mittels dem Potential – sensitiven Fluoreszenzfarbstoff Bis - oxonol aufgebaut und verwendet. Intakte HUVEC zeigten eine basale O2 - - Produktion, die durch bekannte Inhibitoren der leukozytären NAD(P)H – Oxidase, mit unterschiedlichen Wirkmechanismen signifikant gehemmt wurde (Diphenyleniodonium ca. 48%, Phenylarsenoxid ca. 34% ). Ebenso resultierte die Inaktivierung des GTP - bindenden - Proteins rac mit Clostridium difficile Toxin B in einer signifikanten Reduktion der basalen endothelialen O2 - - Produktion um ca. 30%. Weiterhin konnte gezeigt werden, daß nach Aufhebung der zellulären Integrität durch das Lysieren der HUVEC die Gabe von NADH eine um ca. 2.7 fach erhöhte O2 - - Produktion im Vergleich zu NADPH bewirkte. Mit Hilfe der Immunfluoreszenz bzw. rtPCR konnten außerdem zumindest ein Teil der leukozytären NAD(P)H – Oxidase Untereinheiten, p67phox und gp91phox auch in HUVEC nachgewiesen werden. Zur gezielten Depolarisation des Membranpotentials wurden ein Puffer mit erhöhter Kaliumkonzentration (90 mM), der nicht selektive Kalium – Kanal - Blocker Tetrabutylammonium Chlorid (1 mM) und das Kation – Ionophor Gramicidin (1 µM) verwendet. Die basale endotheliale O2 - - Produktion wurde durch diese Substanzen in ähnlichem Ausmaß (~ 60% ) signifikant gesteigert (n=23, p

Die vorliegende Arbeit beschäftigt sich mit dem Einfluss von Drogenextrakten und Naturstoffen auf die endotheliale NO-Synthase (eNOS) in humanen Endothelzellen (Primärkulturen und Zelllinien). Insbesondere wurde dabei ihr Einfluss auf den verschiedenen zellulären Ebenen (Transkription, Proteinexpression, NO-Synthese) untersucht. Da es in dieser Arbeitsgruppe die erste Arbeit auf dem Gebiet der eNOS war, mussten zunächst Methoden etabliert und entwickelt werden, mit denen die eNOS auf den verschiedenen zellulären Ebenen detektiert werden kann. Etabliert wurden ein Luciferase-Reportergen-Assay zur Messung der eNOS Promotoraktivität, eine Northern Blot-Methode zur Bestimmung der eNOS-mRNA und eine Western Blot-Methode zur Messung der eNOS Proteinmenge. Entwickelt wurden ein L-Arginin/L-Citrullin Umwandlungsassay zur Bestimmung der eNOS-bedingten L-Citrullin-produktion und ein DAF-2 Fluoreszenzassay zur Messung der eNOS-bedingten NO-Produktion. Getestet wurden Extrakte und Naturstoffe, bei denen bereits positive kardiovaskuläre Eigenschaften wie Vasodilatation bekannt bzw. in der Diskussion waren. Keinen Einfluss auf die eNOS hatten: •Knoblauchextrakte und schwefelhaltige Knoblauchextraktinhaltsstoffe •Der Weißdornblüten- und Blätterextrakt WS1442 •Die Catechinderivate Epicatechin-3-gallat und Epigallocatechin-3-gallat •Die Rotweinpolyphenole Delphinidin, Quercetin, Epicatechin und Rutin Dagegen konnten Isoflavone der Sojabohne, wie Genistein, Daidzein, Formononetin, Biochanin A und Equol die eNOS Promotoraktivität konzentrationsabhängig erhöhen. Genistein (stellvertretend für alle Isoflavone im Western Blot getestet) erhöhte auch die eNOS Proteinmenge. Allerdings bewirkte Genistein, trotzt der Erhöhung der Proteinmenge, keine Erhöhung der eNOS abhängigen Bildung an L-Citrullin und NO. Positive Ergebnisse brachten die Tests mit einem Rotweinpolyphenolextrakt (RWPE). Dieser Extrakt erhöhte signifikant die NO-Produktion in den beiden getesteten Endothelzellarten (EA.hy926 Zellen und HUVECs). Um den molekularen Mechanismus der NO-Produktionserhöhung durch RWPE aufzuklären, wurden verschiedene Ebenen der eNOS Regulation untersucht. Dabei konnte in dieser Arbeit zum ersten mal gezeigt werden, dass RWPE sowohl die eNOS Promotoraktivität als auch die eNOS Proteinexpression erhöht. Die nächste Frage war, ob die NO-Produktionserhöhung kausal mit der gemessenen Transkriptionserhöhung zusammenhängt. Zeitabhängige Untersuchungen auf den verschiedenen Ebenen der eNOS Regulation ergaben ähnliche Ergebnisse mit einer signifikant messbaren Beeinflussung stets nach ca. 10 h. Dies deutet darauf hin, dass RWPE die eNOS-abhängige NO-Produktion über eine Erhöhung der eNOS Transkription/Translation erhöht. Allerdings konnte dies auf Grund fehlender Experimente über eine posttranslationelle eNOS Beeinflussung nicht eindeutig bewiesen werden. Abschließend sollte mit der Suche nach den wirksamen Bestandteilen im RWPE begonnen werden. Auch wenn im Verlauf dieser Arbeit die wirksamen Verbindungen noch nicht gefunden wurden, konnten zumindest einige Substanzen als wirksamkeitsbestimmend oder -mitbestimmend ausgeschlossen werden. Neben einigen nicht wirksamen Rotweinpolyphenolen (Delphinidin, Rutin, Quercetin, Epicatechin) geben die durchgeführten Experimente Hinweise darauf, dass auch Anthocyane, Tannine und oligomere Procyanidine unwirksam sind. Das Stilbenderivat Resveratrol, welches oft als eine kardiovaskulär aktive Komponente im Rotwein angesehen wird, hatte nur einen sehr geringen und auf der Ebene der NO-Produktion nicht signifikanten Effekt auf die eNOS. Zusammenfassend wurde in dieser Arbeit ein Modell zur Messung von Einflüssen auf die eNOS aufgebaut. Von den getesteten Extrakten und Naturstoffen beeinflusste nur RWPE signifikant die eNOS. Es konnte erstmalig gezeigt werden, dass RWPE in Endothelzellen nach Langzeitstimulation (20 h) die eNOS Transkription, eNOS Expression und eNOS bedingte NO-Produktion erhöht. Dieses Ergebnis ist physiologisch äußerst interessant. Denn bisher bekannte, die eNOS Expression erhöhende Substanzen (z.B: Östradiol, Cyclosporin A, Insulin, Phorbolester, Wasserstoffperoxid, Staurosporin, Angiotensin II) sind auf Grund ihrer vielseitigen physiologischen/toxischen Wirkungen therapeutisch zur Prophylaxe und Behandlung von kardiovaskulären Erkrankungen kaum einsetzbar. Die Aufgabe zukünftiger Arbeiten wird es sein, die Wirkung von RWPE in vivo zu untersuchen und die für die Wirkung verantwortlichen Bestandteile des RWPE zu finden.