Podcasts about Latitude

O jornalista e cientista social Luis Daniel Alvarez, diretor da Escola de Estudos Internacionais da Universidade Central da Venezuela, criticou no podcast Latitude as declarações do presidente brasileiro sobre o ditador Nicolás Maduro. Alvarez afirmou que o regime chavista domina pela fome e pelo medo e que a comunidade internacional precisa pressionar para que haja transição para a democracia em seu país. Ele conversou com o jornalista Rogério Ortega. Link do cupom de desconto na assinatura de o Antagonista+ e Crusoé: https://assine.oantagonista.com/?cupom=QUERO60OFF Precisa de ajuda? 4858-5813, São Paulo 4003-8846, demais localidades O horário de atendimento é das 9h00 às 18h00, de segunda a sexta-feira, exceto feriados. Você pode entrar em contato conosco pelo e-mail:  assinante@oantagonista.com Inscreva-se e receba a newsletter:  https://bit.ly/2Gl9AdL Confira mais notícias em nosso site:  https://oantagonista.uol.com.br/ https://crusoe.uol.com.br/ Acompanhe nossas redes sociais:  https://www.fb.com/oantagonista​ https://www.twitter.com/o_antagonista ​https://www.instagram.com/o_antagonista https://www.tiktok.com/@oantagonista_oficial No Youtube deixe seu like e se inscreva no canal: https://www.youtube.com/c/OAntagonista

Mercredi 31 mai, François Sorel a reçu Frédéric Bianchi, journaliste BFM Business, Bertrand Pailhès, directeur des technologies et de l'innovation de la CNIL, Sophie Coulon-Renouvel, directrice croissance externe, partenariats stratégiques et digital chez Crédit Mutuel Arkéa, Santiago Lefebvre, fondateur et président de ChangeNOW, Stanislas Maximin, PDG de Latitude, Sabrina Quagliozzi, correspondante à New York pour BFM Business, Valérie Dmitrovic, directrice générale et cofondatrice de Quest Education Group (Gaming Campus), Chloé Razafritimo étudiante au Gaming Campus, Clément Bordes, ancien étudiant du Gaming Campus et chef de produit chez Karmine Corp, et Alix Poulet, PDG de Leetchi, dans l'émission Tech & Co sur BFM Business. Retrouvez l'émission du lundi au jeudi et réécoutez la en podcast.

Stanislas Maximin, PDG de Latitude, était l'invité de François Sorel dans Tech & Co, ce mercredi 31 mai. Il s'est penché sur les projets d'avenir de Latitude sur BFM Business. Retrouvez l'émission du lundi au jeudi et réécoutez la en podcast.

In today's Tech Talks Daily Podcast, we're coming to you from Latitude 59 in Estonia, hosting an enlightening conversation with the prominent Sten Tamkivi. A stalwart in the tech scene from an early age, Sten established the first digital media agency in Estonia when he was just 18 years old, and played a significant role in Skype's monumental $8.5B sale to Microsoft. Now, Sten is pushing the boundaries of the tech industry with his Plural Platform, where he invests in groundbreaking tech companies at their infancy. Through his multi-family office, Taavet+Sten, he's also making remarkable strides outside of early tech. In our chat today, we'll explore the culture of founders supporting founders, Europe's pivotal role in the global tech scene, and the lessons gleaned from the evolution of Estonia's tech landscape. With Sten, we venture into the world of venture capitalism, challenging the conventional hierarchy and creating a scalable network of peers committed to nurturing the next generation of tech builders. Through his work, he hopes to generate a GDP-level impact on Europe and foster a product-building mindset among the upcoming tech entrepreneurs. I learn how Sten's investment strategy via Plural Platform focuses on the earliest stages of legendary tech companies. His previous work includes founding Teleport (acquired by Topia in 2017), and an 8-year journey with Skype from its startup phase to reaching 300M active users and a $8.5B exit to Microsoft. An active voice for entrepreneurship, tech education, and an open, creative society, Sten continues to shape the future of European tech. Join us as we delve into Sten's inspiring journey and vision, sharing unique insights and exploring innovative strategies. Whether you're a budding entrepreneur, seasoned tech professional, or simply a tech enthusiast, this is a conversation you won't want to miss.

I'm thrilled to be broadcasting from Latitude 59 in Estonia today, renowned as the cradle of the digital revolution. And the person who'll be joining us today is someone who has played a pivotal role in shaping that revolution – Taavi Kotka. Taavi Kotka is not just an entrepreneur, but also the first-ever Chief Information Officer (CIO) for the Government of Estonia. His innovation and vision were key in shaping e-Estonia, the world's most digitally advanced nation. His contributions, notably the world's first e-Residency program, have revolutionized the way the government interacts with its citizens and conducts its operations. Starting his career as a humble programmer and eventually becoming the CEO of Webmedia (now Nortal), Taavi has worn several hats throughout his illustrious career. His achievements range from being crowned Ernst & Young's Entrepreneur of the Year to receiving Estonia's prestigious White Star III Class Order. Now, as a special advisor to the European Commission Vice-President Andrus Ansip on the European Digital Single Market, Taavi continues to influence the tech sphere, whether it's through his startup ventures, consulting for enterprises and governments, or his thought-provoking keynotes at global conferences. In today's episode, we're going to deep dive into a conversation with Taavi Kotka. We'll explore his journey, the milestones he's achieved, and his views on the future of digital governance and transformation. I also learn how for community-led businesses, Koos simplifies shared ownership to let business-critical communities earn and own equity-like stakes in that business without messing with the cap table. As we wrap up this insightful conversation with Taavi, we're reminded of the disruptive power of technology. Through his relentless efforts and innovative thinking, Taavi has transformed not only industries but also an entire nation. His insights into digital transformation, government policy, and the startup ecosystem offer a unique perspective on the future of technology.    

Rússia envia armas nucleares para Belarus e conquista 95% da estratégica cidade de Bakhmut. A Polônia, integrante da Otan, convoca 260 mil soldados. Região russa de Belgorod é invadida por soldados russos que querem derrubar o presidente Vladimir Putin. A especialista em questões militares Barbara Martinelli, colunista do Hoje no Mundo Militar, explica os últimos desenvolvimentos na guerra da Ucrânia. Link do cupom de desconto na assinatura de o Antagonista+ e Crusoé: https://assine.oantagonista.com/?cupom=QUERO60OFF Precisa de ajuda? 4858-5813, São Paulo 4003-8846, demais localidades O horário de atendimento é das 9h00 às 18h00, de segunda a sexta-feira, exceto feriados. Você pode entrar em contato conosco pelo e-mail:  assinante@oantagonista.com Inscreva-se e receba a newsletter:  https://bit.ly/2Gl9AdL Confira mais notícias em nosso site:  https://oantagonista.uol.com.br/ https://crusoe.uol.com.br/ Acompanhe nossas redes sociais:  https://www.fb.com/oantagonista​ https://www.twitter.com/o_antagonista ​https://www.instagram.com/o_antagonista https://www.tiktok.com/@oantagonista_oficial No Youtube deixe seu like e se inscreva no canal: https://www.youtube.com/c/OAntagonista

This week's host, Monica Grant, reads 3 articles from the May 2023 issue of Latitude 38 Sailing Magazine. Hear "Making Sense of a Life at Sea" by Emma Casey, "Master Mariners Racing - An Ageless Tradition" by Martha Blanchfield, and "Going with the Flow” by Ashley Gremel. Follow along and read the articles at https://www.latitude38.com/issues/may-2023/#54, https://www.latitude38.com/issues/may-2023/#64, and https://www.latitude38.com/issues/may-2023/#94

O jornalista Caio Blinder é o entrevistado desta semana do podcast Latitude. Em conversa com Duda Teixeira e Rogério Ortega, ele fala de seus erros e acertos nas previsões na área de política internacional. Também brinca de ser o "CEO e único funcionário" do Instituto Blinder&Blainder, que teria entre suas atribuições a de distribuir palpites sobre fatos do mundo. Link do cupom de desconto na assinatura de o Antagonista+ e Crusoé: https://assine.oantagonista.com/?cupom=QUERO60OFF Inscreva-se e receba a newsletter:  https://bit.ly/2Gl9AdL Confira mais notícias em nosso site:  https://oantagonista.uol.com.br/ https://crusoe.uol.com.br/ Acompanhe nossas redes sociais:  https://www.fb.com/oantagonista​ https://www.twitter.com/o_antagonista ​https://www.instagram.com/o_antagonista https://www.tiktok.com/@oantagonista_oficial No Youtube deixe seu like e se inscreva no canal: https://www.youtube.com/c/OAntagonista

In the summer of 2022, four women, Sophia Denison-Johnston, Brooke Downes, Libby Costello and Adrienne Smith, set a new record for the fastest all female team to row from San Francisco to Hawaii. They completed the journey in 34 days, 14 hours and 20 minutes. Connect with the Latitude 35 Row Team: Brooke Downes Instagram Sophia Denison-Johnston InstagramLibby Costello InstagramAdrienne Smith InstagramLat 35 InstagramLat 35 websiteEpisode partners: Pre-order Shelby Stanger's new book, Will to Wild Listen to Finding Mastery podcast

Sign up on Patreon or Substack now to hear the first episode of Strange New Haven: The Order of Skull and BonesBONUS CONTENTPatreon: https://www.patreon.com/MFTIC?fan_landing=trueRokfin: https://www.rokfin.com/myfamilythinksimcrazySubstack: https://myfamilythinksimcrazy.substack.com/Synchro-Wisdom Dialogue: https://linktr.ee/mysticmarkpodcastKo-fi: https://ko-fi.com/myfamilythinksimcrazyMerch: https://mftic-podcast.creator-spring.comHelp fund the show, I cannot do this without your support.Venmo: @MysticMarkPaypal: @mysticmarkBTC: 3MQBrF1sGKm17icjQZCxuW7Z3R19jLzTZbBuy Me A Coffee: https://www.buymeacoffee.com/MFTICWithout you this Podcast would not exist.SIGN UP ON PATREON/SUBSTACK TO HEAR THE FULL EPISODE CATALOG NOWWalter Bosley, Author and Private Investigator, joins me to discuss his first three books, we start with a debriefing on his initial brush with synchronicity that stuck with him and planted a seed that eventually grew into a pronounced curiosity concerning, Disneyland, Ley Lines or Telluric Currents, and where the two intersect directly under the carousel! Walter explains how the Stanford Research Institute's C. V. Wood was behind what may have been a psychotronic device hidden in plain sight, we then shift into his next book and the beginning of the series of books known as The Empire Of The Wheel, an occult murder mystery that evolves into a plot involving stage magicians, spiritualists, occultists, and members of a shadowy group known as the Sonora Aeroclub. This is a long awaited interview with a brilliant author whose written far too many books to discuss in one interview, these were just the first 3, catch up with Walter's work here: https://www.youtube.com/channel/UC4HCF_8lkc09CHRRP1oe05Q Buy Empire of The Wheel Here: https://bookshop.org/a/86490/9781312835269 or this Book https://bookshop.org/a/86490/9781312837300 Replace this Episode's Artwork email me at mfticpodcast@gmail.comShare This Episode: https://share.transistor.fm/s/de414de3This Podcast is Sponsored by the Hit Kit! check out the Hit Kit Here  https://hitkit.us/New Booklet by Mystic MarkS.E.E.E.N. #3 A.S.C.E.T.I.C. In Strange New Havenhttps://ko-fi.com/s/0f1e2ff76fMFTIC MerchJoin us on TelegramLeave me a message On Telegram!For Exclusive My Family Thinks I'm Crazy Content: Only 5$ get 150+ Bonus Episodes, Sign up on our Patreon For Exclusive Episodes. Check out the S.E.E.E.N.or on Rokfin@MFTICPodcast on Twitter@myfamilythinksimcrazy on Instagram, Follow, Subscribe, Rate, and Review we appreciate you!https://www.myfamilythinksimcrazy.comhttps://altmediaunited.com/my-family-thinks-im-crazy/Listen to Every AMU Podcast with this link. https://lnns.co/pI5xHeyFdfgGET A NEW PODCASTING APP! https://podcastindex.org/appsMUSICAL CREDITSIntro Song by Destiny LabMusic: Radioactive Love By Wicked CinemaOutroMusic: PagesBy ShimmerReleased under a Creative Commons Attribution International 4.0 License Thanks To Soundstripe and FMA CC4.0 ★ Support this podcast on Patreon ★

O diretor de pesquisas da Fundação Human Rights in Cuba, Hugo Achá, afirma no podcast Latitude que o regime da ilha comunista está se tornando cada vez mais parecido com o da Rússia: oligárquico e corrupto. Empresas militares e estatais são, na realidade, comandadas por grupos familiares. Achá também comenta os protestos na ilha e explica por que o governo petista não incluiu cubanos no novo Mais Médicos. Ele conversou com os jornalistas Duda Teixeira e Rogério Ortega. Inscreva-se e receba a newsletter:  https://bit.ly/2Gl9AdL Confira mais notícias em nosso site:  https://oantagonista.uol.com.br/ https://crusoe.uol.com.br/ Acompanhe nossas redes sociais:  https://www.fb.com/oantagonista​ https://www.twitter.com/o_antagonista ​https://www.instagram.com/o_antagonista https://www.tiktok.com/@oantagonista_oficial No Youtube deixe seu like e se inscreva no canal: https://www.youtube.com/c/OAntagonista

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In this episode of ASCO Educational podcasts, we'll explore how we interpret and integrate recently reported clinical research into practice. The first scenario involves a 72-year old man with high-risk, localized prostate cancer progressing to hormone-sensitive metastatic disease.  Our guests are Dr. Kriti Mittal (UMass Chan Medical School) and Dr. Jorge Garcia (Case Western Reserve University School of Medicine). Together they present the patient scenario (1:12), review research evidence regarding systemic and radiation therapy for high-risk localized disease (5:45), and reflect on the importance of genetic testing and (10:57) and considerations for treatment approaches at progression to metastatic disease (16:13).  Speaker Disclosures Dr. Kriti Mittal:  Honoraria – IntrinsiQ; Targeted Oncology; Medpage; Aptitude Health; Cardinal Health  Consulting or Advisory Role – Bayer; Aveo; Dendreon; Myovant; Fletcher; Curio Science; AVEO; Janssen; Dedham Group  Research Funding - Pfizer Dr. Jorge Garcia:  Honoraria - MJH Associates: Aptitude Health; Janssen Consulting or Advisor – Eisai; Targeted Oncology Research Funding – Merck; Pfizer; Orion Pharma GmbH; Janssen Oncology;  Genentech/Roche; Lilly  Other Relationship - FDA Resources  ASCO Article: Implementation of Germline Testing for Prostate Cancer: Philadelphia Prostate Cancer Consensus Conference 2019 ASCO Course: How Do I Integrate Metastasis-directed Therapy in Patients with Oligometastatic Prostate Cancer? (Free to Full and Allied ASCO Members) If you liked this episode, please follow the show. To explore other educational content, including courses, visit education.asco.org. Contact us at education@asco.org. TRANSCRIPT Dr. Kriti Mittal: Hello and welcome to this episode of the ASCO Education Podcast. Today we'll explore how we interpret and integrate recently reported clinical research into practice, focusing on two clinical scenarios: localized prostate cancer progressing to hormone-sensitive metastatic disease; and a case of de novo metastatic hormone-sensitive prostate cancer progressing to castration-resistant disease.   My name is Kriti Mittal and I am the Medical Director of GU Oncology at the University of Massachusetts. I am delighted to co-host today's discussion with my colleague, Dr. Jorge Garcia. Dr. Garcia is a Professor of Medicine and Urology at Case Western Reserve University School of Medicine. He is also the George and Edith Richmond Distinguished Scientist chair and the current chair of the Solid Tumor Oncology Division at University Hospital's Seidman Cancer Center. Let me begin by presenting the first patient scenario.  Case 1: A 72-year-old male was referred to urology for evaluation of hematuria. A rectal exam revealed an enlarged prostate without any nodules. A CT urogram was performed that revealed an enlarged prostate with bladder trabeculations. A cystoscopy revealed no stones or tumors in the bladder, but the prostatic urethra appeared to be abnormal looking. Transurethral resection of the prostate was performed. The pathology revealed Gleason score 4+5=9 prostate cancer, involving 90% of the submitted tissue. PSA was performed one week later and was elevated at 50. Patient declined the option of radical prostatectomy and was referred to radiation and medical oncology.   So I guess the question at this point is, Dr. Garcia, in 2023, how do you stage patients with high-risk localized prostate cancer and how would you approach this case? Dr. Jorge Garcia: That's a great question and a great case, by the way, sort of what you and I in our practice will call ‘bread and butter'. Patients like this type of case that you just presented come from different places to our practice.  So either they come through urology or oftentimes they may come through radiation oncology. And certainly, it depends where you practice in the United States, at ‘X', US, they may come through medical oncology.   So I think that the first question that I have is in whatever role I'm playing in this case, where the patient has seen a urologist or a rad onc or me first, I think it's important for us in medical oncology, at least in the prostate cancer space, to talk about how do we think of their case and put those comments into context for the patient. It's very simple for you to tell a patient you can probably have surgery, radiation therapy, but at the end of the day, how do you counsel that patient as to the implications of the features of his disease is going to be really important. I use very simple examples that I relate to my patients, but really this patient is a patient that has very high-risk prostate cancer based upon the NCCN guidelines and how we actually stratify patients into what we call low-risk, intermediate-, and high-risk, and between those very low and very high risk.  So his PSA is high, very high, I would argue. His Gleason score, now, what we call group grading is high. He has high-volume disease. So the first question that I would have is, what are the choices for treatment for a patient like this? But even before you and I may talk about treatment options, we really want to understand the volume of their disease and whether or not they have localized prostate cancer with high-risk features or whether or not they have locally advanced or hopefully not metastatic disease. So back in the days prior to the FDA approval for PSMA PET imaging, we probably will have a Technetium-99 whole-body bone scan, and/or we probably will actually use CT scanning. Most people in the past, we used to do just a CT of the abdomen and pelvic region. As you know, with the movement of oral agents in the advanced setting, I think most of us will do a chest CT, abdomen and pelvic region, and certainly we also probably will have a Technetium-99 bone scan.  Now, with the utility and the use of PET imaging, I think most people like him will probably undergo PET PSMA, where you use F-18 PSMA or Gallium-68 PSMA. I think the importance depends on how you look at the approval of these two technologies. I think that PET PSMA imaging is here to stay. It's probably what most of us will use. And based upon that, we will define yet the truest stage of this patient. So right now, what we know is he has high-risk features. Hopefully, their disease is localized. We'll probably put the patient through an imaging technology. If you don't have access to a PET, then obviously CT and a bone scan will do. But if you do, the PET will actually help us define if the patient has disease outside of the prostate region, in the pelvic area, or even if they have distant metastases. Dr. Kriti Mittal: I would agree with that approach, Dr. Garcia. I think in the United States, we've been late adopters of PSMA scans. I think this patient with high-risk localized disease, if insurance allows at our institution, would get a PSMA for staging. There are still some patients where insurance companies, despite peer-to-peer evaluations, are not approving PSMAs. And in those situations, the patient would benefit from conventional CTs and a bone scan. So let's say this patient had a PSMA and was found not to have any regional or distant metastases. He decided against surgery, and he is seeing you as his medical oncologist together with radiation. What would your recommendations be?  Dr. Jorge Garcia: I think the bigger question is, do we have any data to suggest or to demonstrate that if in the absence of metastatic disease with conventional imaging or with emerging technologies such as PSMA PET, there is no evidence of distant disease, which I think you probably agree with me, that would be sort of unlikely with a patient with these features not to have some form of PSMA uptake somewhere in their body. But let's assume that indeed then the PSMA PET was negative, so we're really talking about high-risk localized prostate cancer. So I don't think we can tell a patient that radical prostatectomy would not be a standard of care. We never had a randomized trial comparing surgery against radiation therapy. This patient has already made that decision and surgery is not an option for him. If he, indeed, had elected radiotherapy, the three bigger questions that I ask myself are where are you going to aim the beam of that radiation therapy? What technology, dose, and fractionation are you going to use? And lastly, what sort of systemic therapy do you need, if any, for that matter? Where we do have some data maybe less controversial today in 2023 compared to the past? But I think the question is, do we do radiation to the prostate only or do we expand the field of that radiation to include the pelvic nodes?  Secondly, do we use IMRT? Do you use proton beam or not? Again, that's a big question that I think that opens up significant discussions. But more important, in my opinion, is the term of hypofractionation. I think the field of radiation oncology has shifted away from the old standard, five, seven weeks of radiation therapy to more hypofractionation, which in simple terms means a higher dose over a short period of time. And there was a concern in the past that when you give more radiation on a short period of time, toxicities or side effects would increase. And I think that there is plenty of data right now, very elegant data, demonstrated that hypofractionation is not worse with regards to side effects. I think most of us will be doing or supporting hypofractionation. And perhaps even to stretch that, the question now is of SBRT. Can we offer SBRT to a selected group of patients with high-risk prostate cancer? And again, those are discussions that we will naturally, I assume, in your practice, in your group, you probably also have along with radiation oncology.  Now, the bigger question, which in my mind is really not debatable today in the United States, is the need for systemic therapy. And I think we all will go back to the old data from the European EORTC data looking at the duration of androgen deprivation therapy. And I think most of us would suggest that at the very least, 24 months of androgen deprivation therapy is the standard of care for men with high-risk prostate cancer who elect to have local definitive radiation therapy as their modality of treatment. I think that whether or not it's 24 or 36, I think that the Canadian data looking at 18 months didn't hit the mark. But I think the radiation oncology community in the prostate cancer space probably has agreed that 24 months clinically is the right sort of the sweetest spot.  What I think is a bit different right now is whether or not these patients need treatment intensification. And we have now very elegant data from the British group and also from the French group, suggesting, in fact, that patients with very high-risk prostate cancer who don't have evidence of objective metastasis may, in fact, benefit from ADT plus one of the novel hormonal agents, in this case, the use of an adrenal biosynthesis inhibitor such as abiraterone acetate. So I think in my practice, what I would counsel this patient is to probably embark on radiotherapy as local definitive therapy and also to consider 24 months of androgen deprivation therapy. But I would, based upon his Gleason score of group grading, his high-volume disease in the prostate gland, and his PSA, to probably consider the use of the addition of abiraterone in that context. Dr. Kriti Mittal: That is in fact how this patient was offered treatment. The patient decided to proceed with radiation therapy with two years of androgen deprivation. And based on data from the multi-arm STAMPEDE platform, the patient met two of the following three high-risk features Gleason score >8, PSA >40, and clinical >T3 disease. He was offered two years of abiraterone therapy. Unfortunately, the patient chose to decline upfront intensification of therapy. In addition, given the diagnosis of high-risk localized prostate cancer, the patient was also referred to genetic counseling based on the current Philadelphia Consensus Conference guidelines. Germline testing should be considered in patients with high-risk localized node-positive or metastatic prostate cancer, regardless of their family history. In addition, patients with intermediate-risk prostate cancer who have cribriform histology should also consider germline genetic testing.  Access to genetic counseling remains a challenge at several sites across the US, including ours. There is a growing need to educate urologists and medical oncologists to make them feel comfortable administering pretest counseling themselves and potentially ordering the test while waiting for the results and then referring patients who are found to have abnormalities for a formal genetics evaluation. In fact, the Philadelphia Consensus Conference Guideline offers a very elegant framework to help implement this workflow paradigm in clinical practice. And at our site, one of our fellows is actually using this as a research project so that patients don't have to wait months to be seen by genetics. This will have implications, as we will see later in this podcast, not only for this individual patient as we talk about the role of PARP inhibitors but also has implications for cascade testing and preventative cancer screening in the next of kin. Dr. Jorge Garcia: Dr. Mittal, I think that we cannot stress enough the importance of genetic testing for these patients. Oftentimes I think one of the challenges that our patients are facing is how they come into the system. If you come through urology, especially in the community side, what I have heard is that there are challenges trying to get to that genetic counsel. Not so much because you cannot do the test, but rather the interpretation of the testing and the downstream effect as you're describing the consequences of having a positive test and how you're going to counsel that patient. If you disregard the potential of you having an active agent based upon your genomic alteration, is the downstream of how your family may be impacted by a finding such as the DNA repair deficiency or something of that nature. So for us at major academic institutions because the flow how those patients come through us, and certainly the bigger utilization of multi-disciplinary clinics where we actually have more proximity with radiation oncology urology, and we actually maybe finesse those cases through the three teams more often than not, at least discuss them, then I think that's less likely to occur. But I think the bigger question is the timing of when we do testing and how we do it.  So there are two ways -- and I'd love to hear how you do it at your institution -- because there are two ways that I can think one can do that. The low-hanging fruit is you have tissue material from the biopsy specimen. So what you do, you actually use any of the commercial platforms to do genomic or next-generation sequencing or you can do in-house sequencing if your facility has an in-house lab that can do testing. And that only gets you to what we call ‘somatic testing', which is really epigenetic changes over time that are only found in abnormal cells. It may not tell you the entire story of that patient because you may be missing the potential of identifying a germline finding. So when you do that, did you do germline testing at the same time that you do somatic testing or did you start with one and then you send to genetic counseling and then they define who gets germline testing? Dr. Kriti Mittal: So at our site, we start with germline genetic testing. We use either blood testing or a cheek swab assay and we send the full 84-gene multigene panel. Dr. Jorge Garcia: Yeah, and I think for our audience, Dr. Mittal, that's great. I don't think you and I will be too draconian deciding which platform one uses. It's just that we want to make sure that at least you test those patients. And I think the importance of this is if you look at the New England Journal paper from many years ago, from the Pritchard data looking at the incidence of DNA repair deficiency in men with prostate cancer in North America, that was about what,  around 10% or so, take it or leave it. So if you were to look only for germline testing, you only will, in theory, capture around 10% of patients. But if you add somatic changes that are also impacting the DNA pathway, then you may add around 23%, 25% of patients. So we really are talking that if we only do one type of testing, we may be missing a significant proportion of patients who still may be candidates, maybe not for family counseling if you had a somatic change, rather than germline testing, the positivity, but if you do have somatic, then you can add into that equation the potential for that patient to embark on PARP inhibitors down the road as you stated earlier. It may not change how we think of the patient today, or the treatment for that matter. But you may allow to counsel that patient differently and may allow to sequence your treatments in a different way based upon the findings that you have. So I could not stress the importance of the NCCN guidelines and the importance of doing genetic testing for pretty much the vast majority of our patients with prostate cancer. Dr. Kriti Mittal: Going back to our patient, three years after completion of his therapy, the patient was noted to have a rising PSA. On surveillance testing, his PSA rose from 0.05 a few months prior to 12.2 at the time of his medical oncology appointment. He was also noted to have worsening low back pain. A PSMA scan was performed that was noteworthy for innumerable intensely PSMA avid osseous lesions throughout his axial and appendicular skeleton. The largest lesion involved the right acetabulum and the right ischium. Multiple additional sizable lesions were seen throughout the pelvis and spine without any evidence of pathologic fractures. So the question is, what do we do next? Dr. Jorge Garcia: The first question that I would have is, the patient completed ADT, right? So the patient did not have treatment intensification, but at the very least he got at least systemic therapy based upon the EORTC data. And therefore, one would predict that his outcome will have been improved compared to those patients who receive either no ADT or less time on ADT. But what I'm interested in understanding is his nadir PSA matters to me while he was on radiation and ADT. I would like to know if his nadir PSA was undetectable, that's one thing. If he was unable to achieve an undetectable PSA nadir, that would be a different thought process for me.   And secondly, before I can comment, I would like to know if you have access to his testosterone level. Because notably, what happens to patients like this maybe is that you will drive down testosterone while you get ADT, PSAs become undetectable. Any of us could assume that the undetectability is the result of the radiation therapy. But the true benefit of the combination of radiation and ADT in that context really comes to be seen when the patient has got off the ADT, has recovered testosterone, and only when your testosterone has normalized or is not castrated, then we'll know what happens with your serologic changes. If you rise your PSA while you recover testosterone, that is one makeup of patient. But if you rise your PSA while you have a testosterone at the castrated level, that would be a different makeup of a patient. So do we have a sense as to when the patient recovered testosterone and whether or not if his PSA rose after recovery?  Dr. Kriti Mittal: At the time his PSA rose to 12, his testosterone was 275. Dr. Jorge Garcia: Okay, perfect. You and I would call this patient castration-naive or castration-sensitive. I know that it's semantics. A lot of people struggle with the castration-naive and castration-sensitive state. What that means really to me, castration-naive is not necessarily that you have not seen ADT before. It's just that your cancer progression is dependent on the primary fuel that is feeding prostate cancer, in this case, testosterone or dihydrotestosterone, which is the active metabolite of testosterone. So in this case, recognizing the patient had a testosterone recovery and his biochemical recurrence, which is the rising of his PSA occur when you have recovery of testosterone, makes this patient castration-sensitive. Now the PET scan demonstrates now progression of his disease. So clearly he has a serologic progression, he has radiographic progression. I assume that the patient may have no symptoms, right, from his disease?  Dr. Kriti Mittal: This patient had some low back pain at the time of this visit. So I think we can conclude he has clinical progression as well. Dr. Jorge Garcia: Okay, so he had the triple progression, serologic, clinical, and radiographic progression. The first order of business for me would be to understand the volume of his disease and whether we use the US CHAARTED definition of high volume or low volume, or whether we use the French definition for high volume from Latitude, or whether we use STAMPEDE variation for definition, it does appear to me that this patient does have high-volume disease. Why? If you follow the French, it's a Gleason score of >8, more than three bone metastases, and the presence of visceral disease, and you need to have two out of the three. If you follow CHAARTED definition, we did not use Gleason scoring, the US definition. We only use either the presence of visceral metastases or the presence of more than four bone lesions, two of which had to be outside the appendicular skeleton. So if we were to follow either/or, this patient would be high-volume in nature.  So the standard of care for someone with metastatic disease, regardless of volume, is treatment intensification, is you suppress testosterone with androgen deprivation therapy. And in this case, I'd love to hear how you do it in Massachusetts, but here, for the most part, I would actually use a GnRH agonist-based approach, any of the agents that we have. Having said that, I think there is a role to do GnRH antagonist-based therapy. In this case, degarelix, or the oral GnRH antagonist, relugolix, is easier to get patients on a three-month injection or six-month injection with GnRH agonist than what it is on a monthly basis. But I think it's also fair for our audience to realize that there is data suggesting that perhaps degarelix can render testosterone at a lower level, meaning that you can castrate even further or have very low levels of testosterone contrary to GnRH agonist-based approaches.  And also for patients maybe like this patient that you're describing, you can minimize the flare that possibly you could get with a GnRH agonist by transiently raising the DHT before the hypothalamic-pituitary axis would shut it down. So either/or would be fine with me. Relugolix, as you know, the attraction of relugolix for us right now, based upon the HERO data, is that you may have possibly less cardiovascular side effects. My rationale not to use a lot of relugolix when I need treatment intensification is quite simple. I'm not aware, I don't know if you can mitigate or minimize that potential cardiovascular benefit by adding abiraterone or adding one of the ARIs, because ARIs and abiraterone by themselves also have cardiovascular side effects. But either/or would be fine with me. The goal of the game is to suppress your male hormone.  But very important is that regardless of volume, high or low, every patient with metastatic disease requires treatment intensification. You can do an adrenal biosynthesis inhibitor such as abiraterone acetate. You can pick an androgen receptor inhibitor such as apalutamide or enzalutamide if that's the case. The subtleties in how people feel comfortable using these agents, I think, none of us – as you know, Dr. Mittal - can comment that one oral agent is better than the other one. Independently, each of these three oral agents have randomized level 1, phase III data demonstrating survival improvement when you do treatment intensification with each respective agent. But we don't have, obviously, head-to-head data looking at this.  What I think is different right now, as you know, is the data with the ARASENS data, which was a randomized phase III trial, an international effort looking at triple therapy, and that is male hormone suppression plus docetaxel-based chemotherapy against testosterone suppression plus docetaxel-based chemotherapy plus the novel androgen receptor inhibitor known as darolutamide. This trial demonstrated an outcome survival improvement when you do triple therapy for those high-volume patients. And therefore, what I can tell you in my personal opinion and when I define a patient of mine who is in need of chemotherapy, then the standard of care in my practice will be triple therapy. So if I know you are a candidate for chemotherapy, however, I make that decision that I want you to get on docetaxel upfront. If you have high-volume features, then the standard of care would not be ADT and chemo alone, it would be ADT, chemo, and darolutamide.  What I don't know, and what we don't know, as you know, is whether or not triple therapy for a high-volume patient is better, the same, equivalent, or less than giving someone ADT plus a novel hormonal agent. That is the data that we don't have. There are some meta-analyses looking at the data, but I can tell you that at the very least, if you prefer chemo, it should be triple therapy. If you prefer an oral agent, it certainly should be either apalutamide, abiraterone acetate, and/or enzalutamide. But either/or, patients do need treatment intensification, and what is perplexing to me, and I know for you as well, is that a significant proportion of our patients in North America are still not getting treatment intensification, which is really sub-optimal and sub-standard for our practice.  Dr. Kriti Mittal: Thank you, Dr. Garcia, for a terrific discussion on the application of recent advances in prostate cancer to clinical practice. In an upcoming podcast, we will continue that discussion exploring management of de novo metastatic prostate cancer.   The ASCO Education Podcast is where we explore topics ranging from implementing new cancer treatments and improving patient care to oncologists' well-being and professional development. If you have an idea for a topic or a guest you'd like to see on the ASCO Education Podcast, please email us at education@asco.org. To stay up to date with the latest episodes and explore other educational content, please visit education.asco.org. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions.   Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.    

Inscreva-se e receba a newsletter:  https://bit.ly/2Gl9AdL Confira mais notícias em nosso site:  https://oantagonista.uol.com.br/ https://crusoe.uol.com.br/ Acompanhe nossas redes sociais:  https://www.fb.com/oantagonista​ https://www.twitter.com/o_antagonista ​https://www.instagram.com/o_antagonista https://www.tiktok.com/@oantagonista_oficial No Youtube deixe seu like e se inscreva no canal: https://www.youtube.com/c/OAntagonista

Inscreva-se e receba a newsletter:  https://bit.ly/2Gl9AdL Confira mais notícias em nosso site:  https://oantagonista.uol.com.br/ https://crusoe.uol.com.br/ Acompanhe nossas redes sociais:  https://www.fb.com/oantagonista​ https://www.twitter.com/o_antagonista ​https://www.instagram.com/o_antagonista https://www.tiktok.com/@oantagonista_oficial No Youtube deixe seu like e se inscreva no canal: https://www.youtube.com/c/OAntagonista

Rewire the sensations in the physical, mental, and emotional bodies. Reinstall hope, humility, latitude & liberation in thoughts and words. ** Join The 13 Moons Community with Guru Singh and practice the new 28-Day Meditation Journey alongside heart-led members like yourself. - JOIN NOW - Connect with Guru Singh: Website I http://www.gurusingh.com Instagram I https://www.instagram.com/gurusinghyogi Facebook I https://www.facebook.com/gurusinghyogi Youtube I https://www.youtube.com/c/GuruSinghCommunity Check out 'Buried Treasures' written by Guru Singh I https://www.gurusingh.com/shop Subscribe to Messages From The Omniverse: Spotify I https://open.spotify.com/show/0Rdv5gv4xkEDwG9AJjkWHf Stitcher I https://www.stitcher.com/s?fid=695247 Apple Podcast I https://podcasts.apple.com/us/podcast/messages-from-the-omniverse/id1616724716 Anchor I https://anchor.fm/gurusingh Love You. Bless You. Sat Nam Guru Singh

Neste episódio do podcast Latitude, o analista político paraguaio Alfredo Boccia Paz conversa com os jornalistas Duda Teixeira e Rogério Ortega sobre como será a relação entre o presidente eleito Santiago Peña, do Partido Colorado, e o brasileiro Lula. Para ele, não haverá muita pressão para aumentar o valor da energia de Itaipu comprada pelo Brasil. Boccia Paz também explica o "bipartidismo assimétrico" paraguaio e comenta a situação dos brasileiros e seus descendentes no país. Inscreva-se e receba a newsletter:  https://bit.ly/2Gl9AdL Confira mais notícias em nosso site:  https://oantagonista.uol.com.br/ https://crusoe.uol.com.br/ Acompanhe nossas redes sociais:  https://www.fb.com/oantagonista​ https://www.twitter.com/o_antagonista ​https://www.instagram.com/o_antagonista https://www.tiktok.com/@oantagonista_oficial No Youtube deixe seu like e se inscreva no canal: https://www.youtube.com/c/OAntagonista

Toby is talking about how the ATFE and other government agencies, have given themselves a broad latitude of powers of authority. Now we face a whole new era of rule changes. Then Toby targets the chat questions and calls about firearms, the 2nd amendment and self-defense. In the entire second hour we have special guest … Continue reading Broad Latitude →

Those GPS numbers on your smartphone pinpoint your latitude and longitude — your position on Earth's surface. Latitude is your position north or south of the equator, usually expressed in degrees, minutes, and seconds. And longitude is your position east or west, in hours, minutes, and seconds. Astronomers use a projection of those coordinates to define locations in the sky. Instead of latitude, though, the north-south position is known as declination. And the east-west position is called right ascension. There's a difference in the land-based and sky-based coordinates, though — the celestial ones change position. Earth wobbles on its axis, which causes the stars to shift around the sky. So when astronomers use a star's coordinates, they have to specify time as well. As an example, consider Spica, the brightest star in Virgo. Today, it's at right ascension 13 hours, 26 minutes, 12 seconds, and a declination of minus 11 degrees, 17 minutes, and four seconds. But astronomers frequently use the location from the year 2000 to provide a fixed time. In that system, Spica is 13 hours, 25 minutes, 12 seconds, by 11 degrees, nine minutes, and 42 seconds — a slight but well-understood difference. Tonight, there's an easy way for most of us to spot Spica: It's quite close to the Moon at nightfall, and stays close throughout the night.  Script by Damond Benningfield Support McDonald Observatory

As you will have heard many times on this podcast series so far, Paul Weller has a long tradition of supporting up and coming music artists. Welsh neo soul artist Nia Wyn is another huge talent to get his stamp of approval and it was a real joy to hear her story on this episode of the Paul Weller Fan Podcast.Her music takes influence from Soul, RnB, Jazz, Pop and Hip-Hop to create something new, something that is uniquely hers. Trust me when I say that her incredible, unmistakable vocals will blow you away with each release and live performance....In our podcast chat, we dig into the recent past to hear about her connections with Paul Weller from a WhatsApp intro that leads to Paul picking Nia up from Woking station for a songwriting and recording session at Black Barn Studio (Paul Weller HQ) and the creation of her beautiful soulful song “Turnstyles”.Released as a single in June 2018, Paul plays bass, hammond organ and piano and sings backing vocals on the song.We also chatted about live performance and as you'll hear on the podcast, Nia opened for Paul at his concert in York in August 2018, along with supporting him on dates for the rescheduled-rescheduled On Sunset / Fat Pop tour in 2021.2022 saw her release more new music with her Magical Thinking EP and she also reached the finals of Glastonbury Festival's Emerging Talent competition. That Summer saw her go on to play the Somerset festival along with Latitude and she supported Paul Weller again at Lytham Festival... Not a bad year right?Nia is another artist, to be endorsed by Paul, whose songs take you on a journey.A raw and powerful style of storytelling that at times can be observational - stories about others, in the third person or more often it would seem that she is singing something deeply personal, open, honest and introspective. Not afraid to wear her heart on her sleeve to tackle topics that may appear to be taboo (her own mental health challenges as example) in an age where those areas of discussion really shouldn't be.She has an incredible knack of making you think with her music whilst also having that all important gift of melody. Every release so far has been pretty special and builds on what has come before and I'm genuinely excited by what is to come in the future. Hosted on Acast. See acast.com/privacy for more information.

The Office of the Privacy Commissioner says it's time for Kiwis to start pushing back on how their data is being collected and retained in the wake of the biggest-ever data breach. A million past and present New Zealand drivers' licences were caught up in a mid-March cyber attack on Latitude Financial, which offers loans and credit to customers at stores including JB Hi-Fi and Harvey Norman. In total some 14 million New Zealand and Australian customer records were stolen. The Office of the Privacy Commissioner is working with its Australian counterpart on this, and there's the potential for joint investigations and regulatory action. In the meantime, it says this breach should serve as a wake up call to companies and agencies to ditch the "it won't happen to us" attitude. It also wants Kiwis to challenge why an agency needs to collect and retain their personal information - because the more people challenge, the more likely it is that organisations will change their behaviour. Deputy Commissioner Liz McPherson joins Kathryn to discuss.

O escritor e cientista político português João Pereira Coutinho fala dos protestos contra Lula em sua visita a Portugal, que não se limitaram à “extrema direita”. Também explica como a esquerda do país se apropriou da Revolução dos Cravos apesar de ter perdido a disputa política por ela, comenta a decepção de Chico Buarque com os rumos da democracia portuguesa e diz como os portugueses veem a guerra na Ucrânia. JOÃO PEREIRA COUTINHO é escritor, doutor em ciência política e relações internacionais pelo Instituto de Estudos Políticos da Universidade Católica Portuguesa e colunista da Folha de S.Paulo. Inscreva-se e receba a newsletter:  https://bit.ly/2Gl9AdL Confira mais notícias em nosso site:  https://oantagonista.uol.com.br/ https://crusoe.uol.com.br/ Acompanhe nossas redes sociais:  https://www.fb.com/oantagonista​ https://www.twitter.com/o_antagonista ​https://www.instagram.com/o_antagonista https://www.tiktok.com/@oantagonista_oficial No Youtube deixe seu like e se inscreva no canal: https://www.youtube.com/c/OAntagonista

Integrante do movimento MendoExit, que pede maior autonomia para a província de Mendoza, o argentino Hugo Laricchia fala neste episódio do podcast Latitude sobre a inclinação política de sua região, onde o libertário Javier Milei está à frente nas pesquisas, e sobre as eleições presidenciais deste ano. Guia turístico, ele também comenta as inovações no mundo das “bodegas”, como o vinho amarelo: vinho branco feito com a pele das uvas. Inscreva-se e receba a newsletter:  https://bit.ly/2Gl9AdL Confira mais notícias em nosso site:  https://oantagonista.uol.com.br/ https://crusoe.uol.com.br/ Acompanhe nossas redes sociais:  https://www.fb.com/oantagonista​ https://www.twitter.com/o_antagonista ​https://www.instagram.com/o_antagonista https://www.tiktok.com/@oantagonista_oficial No Youtube deixe seu like e se inscreva no canal: https://www.youtube.com/c/OAntagonista

This week's host, Monica Grant, reads 2 articles from the March 2023 issue of Latitude 38 Sailing Magazine. Hear John Arndt share the sailing legacy of the rock legend in "David Crosby - Harmony at Sea" and Vikki Fennell cruise Panama with her family in “The Route Less Traveled.” Follow along and read the articles at https://www.latitude38.com/issues/march-2023/#62 and https://www.latitude38.com/issues/march-2023/#97

O Latitude deste sábado (15) conversou com Dorival Guimarães Jr., professor de direito internacional no Ibmec de Belo Horizonte e coordenador do curso de direito da Skema Business School - Brasil, sobre a reforma da Previdência proposta por Emmanuel Macron e os protestos que ela tem provocado em toda a França. Na sexta (14), o Conselho Constitucional francês avalizou o ponto mais polêmico da reforma, o aumento da idade mínima de aposentadoria de 62 para 64 anos. O presidente venceu, mas seu futuro político é incerto. Inscreva-se e receba a newsletter:  https://bit.ly/2Gl9AdL Confira mais notícias em nosso site:  https://oantagonista.uol.com.br/ https://crusoe.uol.com.br/ Acompanhe nossas redes sociais:  https://www.fb.com/oantagonista​ https://www.twitter.com/o_antagonista ​https://www.instagram.com/o_antagonista https://www.tiktok.com/@oantagonista_oficial No Youtube deixe seu like e se inscreva no canal: https://www.youtube.com/c/OAntagonista

If you want to get in contact with us you can reach us via email at ⁠associatedpodcast@gmail.com⁠ as well as on Twitter (@associated_pod). We are trying to understand our listeners better so we can make better content. You can really help us out by filling out our listener survey which you can find here (https://airtable.com/shraJVvUNv6D7PkDP). Description: For Episode 2 of Season 8, our newest series on ‘How to raise a venture fund', Danielle and Tunde talk to Julian Rowe, a GP of Latitude, a sister fund of Local Globe and under the parental umbrella that is Phoenix Court Group. Founded in 2002, the Local Globe is one of the oldest pre-seed and seed specialists in Europe and have recently launched two new later stage funds, Latitude (Growth) and Solar (pre-IPO). They have raised over ten separate funds and have invested in some of Europe's biggest unicorns including Zoopla and Transferwise. Julian unveils his fascinating journey into venture and delves into his perception of the LP landscape in Europe compared to the more mature US scene. In addition, Julian gives some fantastic advice to future GPs on how to build strong relationships with LPs and how to think about your strategy and team composition as your fund matures. It is not an episode to miss!

In this episode Jesse interviews Jonathan Fastborg, Disc golf vlog guru at Latitude 64. As a fellow content creator Jesse has built a great relationship with Jonathan over the past few years and decided a content creation master class was in order. This episode is full of amazing insights, tons of laughs, and an inspiring story about how someone with no disc golf background forged their way into a full-time career in the sport. You can learn more about Jonathan by watching his vlogs at ⁠youtube.com/@Latitude64 If you want to help support the show by purchasing one of the official Patent Pending T-Shirt you can follow the link below to get yours today! ⁠www.jomezpro.com/merch/patent-pending-tee/ ⁠ This episode is sponsored by Trash Panda Disc Golf! ⁠trashpandadiscgolf.com⁠

O ex-presidente boliviano, que pretende disputar mais uma vez as eleições de seu país em 2025, está se desentendendo com o presidente Luis Arce Catacora (indicado por ele), com o ex-vice-presidente Álvaro García Linera, com a Comissão Interamericana de Direitos Humanos e com outros integrantes do Movimento ao Socialismo, o partido que ele fundou. Para falar sobre o assunto, Duda Teixeira conversa com o cientista político boliviano Santiago Terceros, de Santa Cruz de la Sierra. Inscreva-se e receba a newsletter:  https://bit.ly/2Gl9AdL Confira mais notícias em nosso site:  https://www.oantagonista.com​ https://crusoe.uol.com.br/ Acompanhe nossas redes sociais:  https://www.fb.com/oantagonista​ https://www.twitter.com/o_antagonista ​https://www.instagram.com/o_antagonista https://www.tiktok.com/@oantagonista_oficial No Youtube deixe seu like e se inscreva no canal: https://www.youtube.com/c/OAntagonista

There aren't many multilingual, multinational television shows that have been running for nearly seven decades. But what makes the Eurovision Song Contest so special to me is not the music, or the dancing, or the costumes that range from spangletastic to tear-off: no, it's the people butting heads about language. Historian Dean Vuletic, author of Postwar Europe and the Eurovision Song Contest, recounts the many changes in Eurovision's language rules, and its language hopes and dreams. This is the first of a two-part Eurovisionallusionist. In the next instalment: dictators. Protests. Boom Bang-A-Bang Ding-a-Dong Diggi-Loo Diggi-Ley. Find out more about this episode at theallusionist.org/eurovision1, where there's also a transcript. The Allusionist's online home is theallusionist.org. Stay in touch at facebook.com/allusionistshow,instagram.com/allusionistshow, youtube.com/allusionistshow and twitter.com/allusionistshow. Support the show at theallusionist.org/donate and as well as keeping this independent podcast going, you also get glimpses into how the podsausage is made, regular livestreams, AND membership of the delightful Allusioverse Discord community with whom I will be watching the Eurovision final next month. The Allusionist is produced by me, Helen Zaltzman. Martin Austwick provides the original music. Hear Martin's own songs via PaleBirdMusic.com. Our ad partner is Multitude. If you want me to talk lovingly and winningly about your product or thing, sponsor an episode: contact Multitude at multitude.productions/ads. This episode is sponsored by: • Bombas, whose mission is to make the comfiest clothes ever, and match every item sold with an equal item donated. Go to bombas.com/allusionist to get 20% off your first purchase. • Squarespace, your one-stop shop for building and running a beautifully designed website. Go to squarespace.com/allusionist for a free 2-week trial, and get 10 percent off your first purchase of a website or domain with the code allusionist.Support the show: http://patreon.com/allusionistSee omnystudio.com/listener for privacy information.

Mark interviews Sudbury area writers Matthew Del Papa and Vera Constantineau. Prior to the interview, Mark shares a few listener comments reminds listeners about sending THEIR reflections for forthcoming Episode 300, provides a personal update and shares a word about this episode's sponsor. You can learn more about how you can get your audiobooks distributed to retailers and library systems around the world at starkreflections.ca/Findaway. During the interview, Mark, Mat and Vera talk about: Vera and Mat's backgrounds as writers How humor is always going to show up in almost anything that Vera writes Haibun Poetry, which is a form that combines haiku and with prose poem Mat's very first book of "railroad stories" and how a lot of his work is focused on his home town of Capreol, Ontario What's funny about disability? How humor can be a coping mechanism for dealing with frustration Vera's love of poetry and fascination with Japanese forms of writing How poetry is a way of giving the shortest word picture imaginable The uniqueness of Latitude 46 Publishing, the publisher releasing both of these books in the spring of 2023 The way large publishers commonly make "we just published a book like that" restrictions Mat and Vera billing themselves as the "Rolling Writers" when promoting these books How small presses can be a really great resource for writers A focus on what is unique about writers from Northern Ontario and the mutual respect and understanding in the local writing community The benefits and drawbacks of being a writer in a northern community as opposed to a larger city A bit about Sudbury Wordstock, a fantastic literary festival that is celebrating its 10th year in 2023 A look at the geography and physical breadth of Canada and how one has to really hustle and really "want it" in order to be successful as a performer in Canada The term "criplit," the divisiveness in the use of the term among disabled writers and why that writing is important How the use of Zoom during the pandemic has been a boon for folks who have mobility issues and difficulty getting out and about Dealing with the inability to travel for book promotions Vera becoming a Poet Laureate of Greater Sudbury the day the pandemic started, but how that helped her bring Sudbury to the world How the pandemic taught a lot of able bodied people the concept of "not being able to do something you want to be able to do" And more... After the interview Mark reflects on the important of community, the uniqueness of the Sudbury writing community, and an element from Mat's email signature that he finds inspiring.   Links of Interest: Matthew Del Papa's Website Vera Constantineau's Website Latitude 46 Publishing EP 224 - Being an Independent Publisher and Bookseller with Heather Campbell EP 189 - From Stage to Page and Back to Stage with Rod Carley Sudbury Writers Guild Findaway Voices Submit YOUR reflections for Episode 300 Buy Mark a Coffee Patreon for Stark Reflections Best Book Ever Podcast Lovers Moon Podcast The Relaxed Author Buy eBook Direct Buy Audiobook Direct Publishing Pitfalls for Authors An Author's Guide to Working with Libraries & Bookstores Wide for the Win Mark's Canadian Werewolf Books This Time Around (Short Story) A Canadian Werewolf in New York Stowe Away (Novella) Fear and Longing in Los Angeles Fright Nights, Big City Lover's Moon Hex and the City The Canadian Mounted: A Trivia Guide to Planes, Trains and Automobiles   Matthew Del Papa lives in Capreol. He joined the Sudbury Writers' Guild in 2009 and served two years as president. A voracious reader, Matthew has written for local newspapers and websites, contributed to magazines, and together with Lisa Coleman-Brown co-authored a fund-raising novella entitled Nightmare at the North Pole for the Northern Ontario Railroad Museum & Heritage Centre (Greater Sudbury's #3 tourist attraction). Having self-published ten titles, either as author or editor (and sometimes both), Matthew always has a project or two on the go. The majority of his work is humorous and focused on Northern Ontario, specifically his home town. His titles include: The Legend of Capreol Red: And Other Stories From a Railroad Town; Nursing Doubts: The Miss Hattie Mysteries; Green Eyes Through Capreol: More Stories From a Railroad Town; Creepy Capreol: Chilling Tales From a Railroad Town; Captivating Capreol: Thoughts From a Railroad Town; Creepy Capreol, Jr.: Chilling Tales From—and For—Young Minds; Capreol At Bat: The Fastball Years; Creepy Capreol, Jr. 2: Too Many Zombies; and Merry Capreol: Christmas Stories From a Railroad Town. Matthew's first essay collection, Jerry Lewis Told Me I Was Going to Die, is being released May 6th, 2023 by Latitude 46 Publishing.   Vera Constantineau lives in Copper Cliff, ON. She served a two-year term (2020-2022) as poet laureate of Greater Sudbury. The pandemic arrived on the scene the day her appointment was affirmed forcing her to rethink the role, which was very community oriented. She spent a good part of her two years on zoom and travelled around the world to workshops and poetry events. Her podcast, The PL Pod, gathered a following that included regular listeners in the UK, Ireland, Japan, Sweden and Australia as well as the US and Canada. Her poetic focus is the Japanese forms of haiku, senryu, tanka and haibun. In addition to her interest in poetry, Vera writes both fiction and nonfiction. In 2019 her essay Options was included in an anthology, Against Death—35 Essays on Living, published by Anvil Press of Vancouver. In 2020 her haiku placed third in the Martin Lucas Award for Haiku in England. Vera's early writing coered a ten year span as a humour columnist. Her weekly column appeared in several Northern Ontario Community newspapers. Vera is the author of Daisy Chained, a collection of short fiction, three lines at a time, a chapbook of haiku that has gotten excellent reviews. Vera is the Haiku Canada Regional Representative for Ontario and a member of the Haiku Society of America, a member and past president of the Sudbury Writers' Guild as well as a member of NOWW Thunder Bay. Her poetry collection, Enlightened By Defilement was published in April of 2023 through Latitude46 Publishing of Greater Sudbury. The introductory, end, and bumper music for this podcast (“Laser Groove”) was composed and produced by Kevin MacLeod of www.incompetech.com and is Licensed under Creative Commons: By Attribution 3.0 

If offered the choice between a mooring ball or anchoring, which would you choose? It's sometimes a matter of trust. Latitude 38 article on Archer Mooring Failure: https://www.latitude38.com/lectronic/bad-night-bora-bora-lagoon/   Nica email - nica@fit2sail.com  Carolyn email - carolyn@theboatgalley.com Subscribe to the Boat Galley Newsletter! - https://bit.ly/3WHCU2n Today's episode of The Boat Galley Podcast is sponsored by MantusMarine.com, maker of the Mantus anchor, now available in models with and without a roll bar. Proven to set reliably in the most challenging bottoms, the Mantus anchor digs like no other, making anchoring safer and boating more enjoyable. Mantus Marine brings to market practical, durable and affordable marine products, including: anchoring gear, scuba diving accessories, and rechargeable waterproof headlamp for hands-free lighting and solar charging Navigation light. Visit MantusMarine.com and see for yourself! Click to see all podcast sponsors, past and present. - https://bit.ly/3idXto7 Music: “Slow Down” by Yvette Craig      

Tech commentator Anthony Grasso joins Kathryn to talk about the hack of finance company Latitude and how it's dealt with the loss of customer data. What should companies do after a breach? As hundreds of millions of people rush to use ChatGPT, a bug in the system meant that users' conversations were briefly exposed. Could that be more risky than the release of a car license, for example? Japan plans to restrict some computer chip-making exports, further putting pressure on China and cyber police in Ukraine bust a phishing gang.

As Indonesia, Somalia, Niger, and Mauritania may be next to join the Abraham Accords, what interests unify these countries on Accord agreement? What will be the impact of Saudi Arabia’s alignment with Iran? What are the balance of power dynamics for the Iran-concerned Accord countries of Israel, Bahrain, UAE? What binds signatories to the Accords as regional political pressures mount? Discussants will assess the impact of the normalization of relationships they have evolved in the two and a half years since Accords were negotiated. Cultural shifts are already reported after two years of active Accords with Hebrew frequently spoken on the streets of Dubai. Trade has flourished. Flights and overflights are routine. But the United States’ role has shifted for a variety of reasons. Is America’s leadership critical to salutary Accord developments? Featuring: David P. Goldman, President, Macrostrategy LLC Hon. Brian Hook, Founder, Latitude, LLC Prof. Bernard Haykel, Professor of Near Eastern Studies & Director of the Institute for Transregional Study of the Contemporary Middle East, Princeton University Moderator: Prof. Jamil Jaffer, Adjunct Professor, NSI Founder, and Director, National Security Law & Policy Program, Antonin Scalia Law School, George Mason University --- To register, please click the link above.

The worrying trend of hacking attacks on leading Australian companies continues. The personal data of about 14 million of its customers in Australia and New Zealand has been compromised from Latitude Financial's database. Almost 8 million driver's license numbers were also stolen, including 53,000 passport numbers. - Zabrinjavajući trend hakerskih napada na vodeće australske kompanije se nastavlja. Iz baze podataka kompanije Latitude Financial ugroženi su lični podaci oko 14 miliona njegovih klijenata u Australiji i Novom Zelandu. Također su ukradeni brojevi skoro 8 miliona vozačkih dozvola, kao i 53.000 brojeva pasoša.

Latitude Financial is the latest company to suffer a large-scale data breach. This is what experts say needs to change to ensure our data is better protected. - 호주의 대출 전문 회사 라티튜드(Latitude)가 밝힌 사이버 공격 피해는 하비 노만(Harvey Norman), JB Hi-Fi, 굿 가이즈(The Good Guys)의 일부 고객만 피해를 입었다고 발표했던 당초 피해 예상 규모보다 훨씬 더 심각한 것으로 알려졌다.

O embaixador Paulo Roberto de Almeida conversa com Rogério Ortega e Duda Teixeira sobre as posições adotadas pela diplomacia petista em relação aos grandes temas da política internacional, como a invasão da Ucrânia e a retórica belicista da China Inscreva-se e receba a newsletter:  https://bit.ly/2Gl9AdL Confira mais notícias em nosso site:  https://www.oantagonista.com​ https://crusoe.uol.com.br/ Acompanhe nossas redes sociais:  https://www.fb.com/oantagonista​ https://www.twitter.com/o_antagonista ​https://www.instagram.com/o_antagonista https://www.tiktok.com/@oantagonista_oficial No Youtube deixe seu like e se inscreva no canal: https://www.youtube.com/c/OAntagonista  

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Inscreva-se e receba a newsletter:  https://bit.ly/2Gl9AdL Confira mais notícias em nosso site:  https://www.oantagonista.com​ https://crusoe.uol.com.br/ Acompanhe nossas redes sociais:  https://www.fb.com/oantagonista​ https://www.twitter.com/o_antagonista ​https://www.instagram.com/o_antagonista https://www.tiktok.com/@oantagonista_oficial No Youtube deixe seu like e se inscreva no canal: https://www.youtube.com/c/OAntagonista  

Inscreva-se e receba a newsletter:  https://bit.ly/2Gl9AdL Confira mais notícias em nosso site:  https://www.oantagonista.com​ https://crusoe.uol.com.br/ Acompanhe nossas redes sociais:  https://www.fb.com/oantagonista​ https://www.twitter.com/o_antagonista ​https://www.instagram.com/o_antagonista https://www.tiktok.com/@oantagonista_oficial No Youtube deixe seu like e se inscreva no canal: https://www.youtube.com/c/OAntagonista  

This week's host, Monica Grant, is joined by Andrew Vik to chat bold boat buying. Andrew's a San Francisco native who took up sailing over 20 years ago, and has spent the last 15 years sailing his Islander 36 "Geja" all over the Mediterranean. Hear his multi-year dream of buying Geja, lessons learned from buying sight unseen, his favorite sailing stories from the Mediterranean, why more people should get involved in sailing, and a cruise down Latitude 38 memory lane. Learn more about Andrew on YouTube @SailGeja and at http://sailgeja.com/2015/Home/Home.html

The cyber hack on Latitude Financial is far worse than originally thought with customer data stolen from around 14 million of its customers in Australia and New Zealand. - オーストラリア、またニュージーランドに持つ顧客のデータが盗まれたラティチュード・ファイナンシャルの受けたサイバー攻撃。このハッキングの被害は当初考えられていたよりもはるかに悪く、1400万人の顧客データが盗まれたということです。

The number of people caught up in the hacking of data from financial company Latitude is higher than first thought - so what options are there for affected Kiwis? Latitude was hacked two weeks ago, with an initial 330,000 people at risk - but that's now risen to 14 million - including 7.9 million Kiwis and Australians whose driver's licences were stolen. Kiwibank has confirmed at least 2000 customers' ID details have been taken. Kathryn speaks to Keith McLaughlin of Centrix Credit Bureau about what people can do to protect themselves from identity fraud.

O Latitude deste sábado (25) conversa com Carlos Gustavo Poggio, professor de ciência política e relações internacionais do Berea College. Ele fala sobre as eleições para a Casa Branca, já no ano que vem. Donald Trump vai ser preso? Há alternativas ao nome de Joe Biden entre os democratas? A imigração será um tema importante? Como os americanos veem a aproximação entre Lula e a China? Todas essas respostas e outras mais podem ser conferidas agora. Não percam! Inscreva-se e receba a newsletter:  https://bit.ly/2Gl9AdL Confira mais notícias em nosso site:  https://www.oantagonista.com​ Acompanhe nossas redes sociais:  https://www.fb.com/oantagonista​ https://www.twitter.com/o_antagonista ​https://www.instagram.com/o_antagonista https://www.tiktok.com/@oantagonista_oficial No Youtube deixe seu like e se inscreva no canal: https://www.youtube.com/c/OAntagonista

Links from the show:* The Lazarus Heist: From Hollywood to High Finance: Inside North Korea's Global Cyber War* Connect with Geoff* The Lazarus Heist Podcast* Follow Geoff on Twitter* Follow Ryan on Twitter* Rate the showAbout my guest:From billion-dollar cyber heists to global money laundering rings and crypto-gangsters – Geoff White has covered it all. As an author, speaker, investigative journalist and podcast creator, his work's been featured by Penguin, the BBC, Audible, Sky News, The Sunday Times and many more.His first book, Crime Dot Com, covered cybercrime's emergence as a primal threat to modern society and was published in August 2020 by Reaktion Books. One of the key chapters detailed North Korea's unlikely emergence as a cyber superpower. It was adapted by the BBC World Service into the hit 10-part podcast series The Lazarus Heist, co-created and co-hosted by Geoff, which immediately ranked number one in the UK Apple chart and within the top 7 in the US.The book rights to the podcast were picked up by Penguin Random House. The Lazarus Heist – From Hollywood to High Finance: Inside North Korea's Global Cyber War was written by Geoff and published on 9 June 2022, and is available here.His next book for Penguin, Rinsed, will reveal how technology has revolutionised money laundering, from drug cartels washing their cash in Bitcoin to organised fraud gangs recruiting money mules on social media.He has written and presented two major podcast series for Audible. The Dark Web exposes the shadow internet created by the US military and now home to hackers, crooks and freedom fighters. It has been a top ten hit on the platform since its launch in 2017. Artificial Intelligence: Friend or Foe? reveals the origins of AI, and shows how the technology is seeping into everyday life.Geoff's own podcast series Cybercrime Investigations takes you inside the world of an investigative journalist, detailing the twists and turns as the story unfolds.An experienced public speaker, he has given keynote talks for some of the world's biggest brands, including Mastercard, Orange and Bank of America, in addition to hosting conferences and chairing panels at venues ranging from London's Chatham House think-tank to the Latitude music festival.He was also the co-creator of The Secret Life of Your Mobile Phone, a live, interactive phone hacking stage performance which showed how the global technology industry is harvesting the data leaking from your handset. The show was a sell–out hit at the Edinburgh Fringe Festival 2017, and has been performed at music festivals, political conferences and for corporate clients.As the technology correspondent for Channel 4 News, one of the UK's leading daily news programmes, Geoff won multiple awards for his work on the Snowden leaks, the hacking of Britain's largest ISP TalkTalk and his exposés of fraud in the internet dating industry. He was the creator of the programme's Data Baby project, a unique experiment which used a fictional online persona to expose how personal data is used – and abused – online. Get full access to Dispatches from the War Room at dispatchesfromthewarroom.substack.com/subscribe

Cl0p ransomware hits Hitachi Energy. The US Department of Justice investigates ByteDance in alleged surveillance of journalists. A Hacktivist auxiliary hits Indian healthcare records. Pirated software is used to carry malware. The Effects of cyberattack on Latitude persist. Adam Meyers from CrowdStrike shares findings from the 2023 CrowdStrike Global Threat Report. Rick Howard has the latest preview of CSO Perspectives. And Pompompurin is arrested for an alleged role in BreachForums. For links to all of today's stories check out our CyberWire daily news briefing: https://thecyberwire.com/newsletters/daily-briefing/12/53 Selected reading. Hitachi Energy confirms data breach after Clop GoAnywhere attacks (BleepingComputer) Hitachi Energy Group hit by cyber-attack, says network operations not compromised (cnbctv18.com)  Justice Department Probes TikTok's Tracking of U.S. Journalists (Wall Street Journal)  The FBI And DOJ Are Investigating ByteDance's Use Of TikTok To Spy On Journalists (Forbes) KillNet and affiliate hacktivist groups targeting healthcare with DDoS attacks (Azure Network Security Team) Pro-Russia hackers are increasingly targeting hospitals, researchers warns (Record)  Russian hacktivist group targets India's health ministry (CSO Online) Russian Hacktivist group Phoenix targets India's Health Ministry Website (Threat Intelligence | CloudSEK)  Ukraine warns that hacked software can be infected with Russian viruses (Kyiv Independent) Russian hackers spread infected software through torrents (SSSCIP) Australia's Latitude takes systems offline, Federal Police investigate cyberattack (Reuters) FBI targets notorious cybercrime market with teen's arrest (Washington Post)  Dark Web ‘BreachForums' Operator Charged With Computer Crime (Bloomberg)  Feds arrest alleged BreachForums owner linked to FBI hacks (The Verge)  NY Man Charged as 'Pompompurin,' the Boss of BreachForums (KrebsOnSecurity)  Breach Forums Admin 'Pompompurin' Arrested in New York (Cyber Kendra)  Pompompurin Unmasked: Infamous BreachForums Mastermind Arrested in New York (The Hacker News)

Charlie Eisenhood and Josh Mansfield discuss the new House of Discs -- the parent company of Latitude 64 -- purchasing Dynamic Discs and becoming one of the industry's biggest companies (6:50). They talk with DD founder Jeremy Rusco about his decision to sell and what's next for the company (13:30). Then they preview the Waco Annual Charity Open, including some notable season debuts (and a few key missing players), along with picks, #PurseWatch, an over/under, and more (46:10).

On today's podcast the roles get reversed a little. DJ takes over the hosting duties to pick the brains of Jake Bush and Arron Bleise on their recent moves to work with Latitude Outdoors. DJ dives into what both of them did before moving to Latitude, what they are going to be doing for Latitude and what we can expect form Latitude in the future. Enjoy! Latitude Stick Preorder link: https://www.latitudeoutdoors.com/ Exodus Trail Cams - https://exodusoutdoorgear.com Helix Broadheads - https://www.helixbroadheads.com/ Method Archery - https://vectorcustomshop.com/ Latitude Tree Saddles - https://www.latitudeoutdoors.com/ Garmin Bow Sights - https://www.garmin.com/en-US/c/outdoor-recreation/sportsman-and-tactical-devices/ Promo Codes Method Archery: Use Fall10 at checkout to save 10% on your next order Latitude Outdoors: thefallpodcast to save 25% on your next purchase  Don't forget to check out the Fall Podcast Youtube channel for new content. Subscribe to the channel as well. Thank you. https://www.youtube.com/channel/UCWSCcGJeHHxejFXBZAO83QA For updates from The Fall Podcast The Fall Podcast on Instagram - The Fall Podcast The Fall Podcast on Twitter - The Fall Podcast Twitter The Fall Podcast on Facebook - The Fall Podcast Facebook The Fall Podcast Youtube Channel - The Fall Podcast Youtube Channel  This podcast is a part of the Waypoint TV Podcast Network. Waypoint is the ultimate outdoor network featuring streaming of full-length fishing and hunting television shows, short films and instructional content, a social media network, Podcast Network. Waypoint is available on Roku, Samsung Smart TV, Amazon Fire TV, Apple TV, Chromecast, Android TV, IoS devices, Android Devices and at www.waypointtv.com all for FREE! Join the Waypoint Army by following them on Instagram at the following accounts @waypointtv @waypointfish @waypointhunt @waypointpodcasts Subscribe and Rate us on Itunes: SUBSCRIBE to The Fall Podcast Learn more about your ad choices. Visit megaphone.fm/adchoices

Today's podcast is with the boys that make everything come to life behind the lens for Latitude Outdoors. Cory Godar, Derek Bradeis and Joey Pavlovicz filmed the whole year for a new show called Grit. We dive into the grind of filming from state to state for three months and some of the behind the scenes things that you don't get to see. Enjoy! Latitude Stick Preorder link: https://www.latitudeoutdoors.com/ Exodus Trail Cams - https://exodusoutdoorgear.com Helix Broadheads - https://www.helixbroadheads.com/ Method Archery - https://vectorcustomshop.com/ Latitude Tree Saddles - https://www.latitudeoutdoors.com/ Garmin Bow Sights - https://www.garmin.com/en-US/c/outdoor-recreation/sportsman-and-tactical-devices/ Promo Codes Method Archery: Use Fall10 at checkout to save 10% on your next order Latitude Outdoors: thefallpodcast to save 25% on your next purchase  Don't forget to check out the Fall Podcast Youtube channel for new content. Subscribe to the channel as well. Thank you. https://www.youtube.com/channel/UCWSCcGJeHHxejFXBZAO83QA For updates from The Fall Podcast The Fall Podcast on Instagram - The Fall Podcast The Fall Podcast on Twitter - The Fall Podcast Twitter The Fall Podcast on Facebook - The Fall Podcast Facebook The Fall Podcast Youtube Channel - The Fall Podcast Youtube Channel  This podcast is a part of the Waypoint TV Podcast Network. Waypoint is the ultimate outdoor network featuring streaming of full-length fishing and hunting television shows, short films and instructional content, a social media network, Podcast Network. Waypoint is available on Roku, Samsung Smart TV, Amazon Fire TV, Apple TV, Chromecast, Android TV, IoS devices, Android Devices and at www.waypointtv.com all for FREE! Join the Waypoint Army by following them on Instagram at the following accounts @waypointtv @waypointfish @waypointhunt @waypointpodcasts Subscribe and Rate us on Itunes: SUBSCRIBE to The Fall Podcast Learn more about your ad choices. Visit megaphone.fm/adchoices