Podcasts about group ii

SINGAPORE (ICIS)--Asia's base oils supply is expected to improve slightly in H2 2024, while overall demand will likely improve towards the later part of Q3 with the onset of the seasonal peak.  Group I brightstock supply from southeast Asia and Group II supply from South Korea expected to gradually increase  India demand to pick up in September after monsoon; China demand to remain stagnant amid economic woes  Tight Group I base oils supply to remain offset by sluggish demand  In this podcast, editors Matthew Chong and Michelle Liew discuss trends in the Asian base oils market.

[✐2. Andante] VないForm“Please don't stop studying Japanese.”[00:08]Hello, everyone[00:12]Repeat after me[00:14]Verb. Group I (u-verb)1.  go   [masu form > nai form]2.  read3.  sell4.  get on5.  speak/tell6.  lend7.  hurry[01:05]Verb. Group II (ru-verb)1.  eat2.  advise/educate/teach3.  borrow4.  show5.  be[ 01:46]Verb. Group III (Irregular)1.  do2.  come[02:04]Now, make a sentence as follows.[02:08]For example,Here, hamburger, not eat→ Please don't eat hamburgers here.[02:19]1.  → Please don't sleep here.2.  → Please don't tell the answer.3.  → Please don't write with a ballpoint pen.4.  → Please don't take selfies here.5.  → Please don't come to (the company) work tomorrow.6.  → Please don't study until late at night.[04:23]Let's make a plain style sentence with nai-form.[04:28]1.  Would you like to go to shopping?→ Wanna go to shopping?2.  I don't call (I won't call you) early in the morning.→  I don't call (I won't call you) early in the morning3.  Wait…the light doesn‘t work.→ Wait…the light doesn't come on.4.  I won't sell this house.→ I won't sell this house.5.  What?, isn't there Clooney san?→ What?  isn't there Clooney san?=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=「にほんごのべんきょうをやめないでください」[00:08]みなさん、こんにちは。きょうは [ないForm]です。[00:12]Repeat after me[00:14]Verb. Group I (u-verb)1.  いきます > いかない [ますform >ないform]2.  よみます> よまない3.  うります > うらない4.  のります > のらない5.  はなします > はなさない6.  かします > かさない7.  いそぎます > いそがない[01:05]Verb. Group II (ru-verb)1.  たべます > たべない2.  おしえます >  おしえない3.  かります > かりない4.  みせます > みせない5.  います > いない[01:46]Verb. Group III (Irregular)1.  します > しない2.  きます > こない[02:04]では、つぎのように ぶんを つくってください。[02:08]たとえば、ここで、ハンバーガー、たべません→ここでハンバーガーをたべないでください。[02:19]1.  ここで、ねません→ ここでねないでください。2.  こたえを、おしえません→ こたえをおしえないでください。3.  ボールペンで、かきません→ ボールペンで、かかないでください。4.  ここで セルフィーを、とりません→ ここで セルフィーをとらないでください。5.  あした、かいしゃに、きません→ あした、かいしゃにこないでください。6.  よなかまで、べんきょうしません→ よなかまで、べんきょうしないでください。(よなかまで= until late at night)[04:23]ないFormで Plain Style(1) のぶんをつくってみましょう。[04:28]1.  かいものに いきませんか→ かいものに いかない？2.  あさはやくに、でんわしませんよ。→ あさはやくに、でんわしないよ。(あさはやくに = early in the morning)3.  あれ、でんきがつきませんね。→ あれ、でんきがつかないね。4.  このいえは うりませんよ。→ このいえは うらないよ。5.  あれ、クルーニーさんは いませんか？→ あれ、クルーニさんは いないの？Support the Show.=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=Need more translation & transcript? Become a patron: More episodes with full translation and Japanese transcripts. Members-only podcast feed for your smartphone app. Japanese Swotter on PatreonNote: English translations might sound occasionally unnatural as English, as I try to preserve the structure and essence of the original Japanese.

------------------------------- 通勤學英語VIP加值內容與線上課程 ------------------------------- 通勤學英語VIP訂閱方案：https://open.firstory.me/join/15minstoday 社會人核心英語有聲書課程連結：https://15minsengcafe.pse.is/554esm ------------------------------- 15Mins.Today 相關連結 ------------------------------- 歡迎針對這一集留言你的想法： 留言連結 主題投稿/意見回覆 : ask15mins@gmail.com 官方網站：www.15mins.today 加入Clubhouse直播室：https://15minsengcafe.pse.is/46hm8k 訂閱YouTube頻道：https://15minsengcafe.pse.is/3rhuuy 商業合作/贊助來信：15minstoday@gmail.com ------------------------------- 以下是此單集逐字稿 (播放器有不同字數限制，完整文稿可到官網) ------------------------------- 國際時事跟讀VIP Ep.K751: 台灣對食品中的蘇丹紅實施永久禁令 Taiwan Implements Permanent Ban on Sudan Reds in Food Products Highlights 主題摘要：Taiwan's FDA enforces a permanent ban on Sudan red in food products, emphasizing zero tolerance for this carcinogenic dye.Rigorous testing since December has resulted in the removal of over 205 tons of Sudan red-contaminated chili powder imports.The FDA's proactive measures aim to safeguard public health, target entities deliberately including harmful substances, and uphold international trade relations. In a significant announcement, Taiwan's Food and Drug Administration (FDA) has taken a decisive step in combating the presence of Sudan red, a known carcinogenic dye banned in food products. The FDA's recent declaration underscores the gravity of the situation, with manufacturers and importers facing severe consequences if traces of Sudan red are detected in their food items. This includes the imposition of a permanent importer ban, signaling a zero-tolerance policy towards the substance. Notably, the FDA's strategy also involves the destruction of imports containing Sudan red, rather than opting to return them to manufacturers, as emphasized by FDA Director-General Wu Shou-mei during the announcement. 在一項重大宣告中，衛福部食藥署（FDA）採取了決定性的步驟來打擊蘇丹紅的存在，這是一種已知的食品禁用的致癌染料。食藥署最近的聲明凸顯了情況的嚴重性，製造商和進口商如果在其食品中檢測到蘇丹紅的痕跡，將面臨嚴重後果。這包括對進口商實施永久禁令，表明對該物質的零容忍政策。值得注意的是，在公告中，食藥署署長吳秀梅強調，食藥署的策略還涉及銷毀含有蘇丹紅的進口品，而不是選擇將其退回給製造商。 Since December of the previous year, the FDA has rigorously tested every shipment of chili powder from China. This meticulous approach has led to the removal of over 205 tonnes of products found to contain Sudan red. Plans are underway to destroy these tainted food products, pending authorization from a panel of experts. The introduction of these new guidelines serves a dual purpose: to prevent Chinese manufacturers from attempting to relabel contaminated products and to deter any further attempts to export them to Taiwan. 自去年12月以來，食藥署已經對每一批來自中國的辣椒粉進行了嚴格的測試。這種細致入微的方法已導致超過205噸含有蘇丹紅的產品被移除。正在制定計劃銷毀這些受污染的食品產品，等待專家小組的授權。這些新指導方針的推出具有雙重目的：防止中國製造商試圖重新標記受污染的產品，並阻止進一步試圖將其出口到台灣。 The FDA's proactive measures form part of a broader initiative aimed at safeguarding public health and upholding stringent food safety standards. Notably, the measures do not target exporters from countries with different food safety regulations but focus on penalizing entities that deliberately include harmful substances in their products. This careful delineation is essential for maintaining harmonious international trade relations while ensuring the safety and well-being of consumers within Taiwan. 食藥署的主動措施是更廣泛的保護公共健康和堅持嚴格的食品安全標準的倡議的一部分。值得注意的是，這些措施並不針對具有不同食品安全法規的國家的出口商，而是主要針對那些故意在其產品中包含有害物質的單位實施懲罰。這種細緻的界定對於維護和諧的國際貿易關係以及確保台灣消費者的安全和福祉至關重要。 Sudan red, classified as a Group II carcinogen by the World Health Organization (WHO), presents significant health risks, necessitating swift regulatory action. Recent incidents involving tainted food products highlight the pressing need for proactive measures to combat food adulteration effectively. The FDA's decisive action not only sets a precedent for the strict enforcement of food safety regulations but also underscores the government's unwavering commitment to protecting public health and consumer interests across Taiwan. 蘇丹紅被世界衛生組織（WHO）列為二級致癌物，存在著顯著的健康風險，需要迅速的監管行動。最近涉及受污染食品的事件凸顯了採取積極措施有效打擊食品掺偽的迫切需要。食藥署的果斷行動不僅為嚴格執行食品安全法規設立了榜樣，還凸顯了政府對保護台灣公眾健康和消費者利益的堅定承諾。 In conclusion, Taiwan's FDA has adopted a resolute stance against Sudan red contamination in food products, implementing a permanent ban on importers and manufacturers found with traces of this carcinogenic dye. These measures signify a proactive approach aimed at ensuring food safety and safeguarding consumer health. They serve as a testament to the government's dedication to maintaining robust regulatory oversight within the food industry, thereby reinforcing public trust and confidence in the safety of food products available in Taiwan. 總之，衛福部食藥署已經採取了堅定的立場，反對食品中的蘇丹紅污染，對被發現有這種致癌染料痕跡的進口商和製造商實施了永久禁令。這些措施表明了一種積極主動的方法，目標是確保食品安全並保護消費者健康。它們也證明了政府對在食品行業嚴格執行食品安全法規設立了榜樣，從而加強了公眾對台灣食品安全的信賴與信心。 Keyword Drills 關鍵字：Carcinogenic (Car-cin-o-gen-ic): Taiwan's FDA enforces a permanent ban on Sudan red in food products, emphasizing zero tolerance for this carcinogenic dye.Rigorously (Rig-or-ous-ly): Since December of the previous year, the FDA has rigorously tested every shipment of chili powder from China.Safeguard (Safe-guard): The FDA's actions stem from a broader initiative to safeguard public health and ensure stringent food safety standards.Adulteration (A-dul-ter-a-tion): Recent incidents involving tainted food products underscore the importance of proactive measures to combat food adulteration.Deliberately (De-li-ber-ate-ly): Notably, the measures do not target exporters from countries with different food safety regulations but focus on penalizing entities that deliberately include harmful substances in their products. Reference article: 1. https://www.taiwannews.com.tw/en/news/5107782 2. https://www.taiwannews.com.tw/en/news/5110071 3. https://www.taipeitimes.com/News/taiwan/archives/2024/03/14/2003814906

Mario Majic, head of Strategic Business Development, Marketing & Corporate Governance at Avista Oil AG, says that with today's re-refining technology, base oils produced from spent lubricants can compete head on with “virgin” base oils. Speaking with F&L Asia  in Episode 31 of the F+L Webcast, Majic said re-refined base oils from Avista can achieve up to 90% CO2 emissions savings from cradle to gate compared to primary refined base oils. Historically, buyers expect a discount when they purchase re-refined base oils. However, that's starting to change, says Majic. “A couple of years ago, we were not able to achieve premium prices for our products, but the market is changing. If demand for something is rising and supply is limited, we know what is going to happen,” he says. Avista is a German re-refiner with about 300,000 tons per year of combined base oil production footprint in Germany, Denmark and the United States. The company produces Group II in the United States and is upgrading its facility in Germany to produce Group III. Majic says that “Oil can be green, oil can be clean and oil can be sustainable.” His wish list is to see carbon footprint included in future base oil specifications. In Europe, as well as the rest of the world, the industry uses the base oil classification contained in Annex E of API 1509. API 1509 describes the voluntary Engine Oil Licensing and Certification System (EOLCS) of the American Petroleum Institute (API). All base stocks are divided into five categories. Groups I to III are classified according to their saturates, sulfur and viscosity index (VI). Group IV base stocks are polyalphaolefins (PAOs) and Group V are all other base stocks that are not Groups I-IV. 

A dichotomy in group II Herbig disks: ALMA gas disk height measurements show both shadowed large vertically extended disks and compact flat disks by L. M. Stapper et al. on Thursday 24 November Herbig stars can be classified into group I and group II depending on the shape of the far-IR excess from the spectral energy distribution. This separation may be evolutionary and related to the vertical structure of these disks. We aim to determine the emission height of Herbig disks and compare the resulting vertical extent of both groups. ALMA Band 6 observations of 12CO emission lines at sufficient velocity and spatial resolution of eight Herbig disks (four group I and four group II sources) are used to determine the emission heights from the channel maps via geometrical methods developed in other works. We find that all group I disks are vertically extended with a height to radius ratio of at least 0.25, and for three of the disks the gas emission profile can be traced out to 200-500 au. The group II disks are divided between MWC 480 and HD 163296 which have similar emission height profiles as the group I disks, and AK Sco and HD 142666 which are very flat (not exceeding a height of 10 au) and more compact (

A dichotomy in group II Herbig disks: ALMA gas disk height measurements show both shadowed large vertically extended disks and compact flat disks by L. M. Stapper et al. on Thursday 24 November Herbig stars can be classified into group I and group II depending on the shape of the far-IR excess from the spectral energy distribution. This separation may be evolutionary and related to the vertical structure of these disks. We aim to determine the emission height of Herbig disks and compare the resulting vertical extent of both groups. ALMA Band 6 observations of 12CO emission lines at sufficient velocity and spatial resolution of eight Herbig disks (four group I and four group II sources) are used to determine the emission heights from the channel maps via geometrical methods developed in other works. We find that all group I disks are vertically extended with a height to radius ratio of at least 0.25, and for three of the disks the gas emission profile can be traced out to 200-500 au. The group II disks are divided between MWC 480 and HD 163296 which have similar emission height profiles as the group I disks, and AK Sco and HD 142666 which are very flat (not exceeding a height of 10 au) and more compact (

A dichotomy in group II Herbig disks: ALMA gas disk height measurements show both shadowed large vertically extended disks and compact flat disks by L. M. Stapper et al. on Wednesday 23 November Herbig stars can be classified into group I and group II depending on the shape of the far-IR excess from the spectral energy distribution. This separation may be evolutionary and related to the vertical structure of these disks. We aim to determine the emission height of Herbig disks and compare the resulting vertical extent of both groups. ALMA Band 6 observations of 12CO emission lines at sufficient velocity and spatial resolution of eight Herbig disks (four group I and four group II sources) are used to determine the emission heights from the channel maps via geometrical methods developed in other works. We find that all group I disks are vertically extended with a height to radius ratio of at least 0.25, and for three of the disks the gas emission profile can be traced out to 200-500 au. The group II disks are divided between MWC 480 and HD 163296 which have similar emission height profiles as the group I disks, and AK Sco and HD 142666 which are very flat (not exceeding a height of 10 au) and more compact (

A dichotomy in group II Herbig disks: ALMA gas disk height measurements show both shadowed large vertically extended disks and compact flat disks by L. M. Stapper et al. on Wednesday 23 November Herbig stars can be classified into group I and group II depending on the shape of the far-IR excess from the spectral energy distribution. This separation may be evolutionary and related to the vertical structure of these disks. We aim to determine the emission height of Herbig disks and compare the resulting vertical extent of both groups. ALMA Band 6 observations of 12CO emission lines at sufficient velocity and spatial resolution of eight Herbig disks (four group I and four group II sources) are used to determine the emission heights from the channel maps via geometrical methods developed in other works. We find that all group I disks are vertically extended with a height to radius ratio of at least 0.25, and for three of the disks the gas emission profile can be traced out to 200-500 au. The group II disks are divided between MWC 480 and HD 163296 which have similar emission height profiles as the group I disks, and AK Sco and HD 142666 which are very flat (not exceeding a height of 10 au) and more compact (

SINGAPORE (ICIS) --The base oils markets in Asia and the Middle East remain mixed in Q4 2022, tracking varied supply and demand conditions across different grades. In this chemical podcast, ICIS editors Matthew Chong and Veena Pathare discuss the factors driving base oil prices with an outlook on Q1 2023. Asian Group I base oil tight supply to ease, Group II supply to lengthen Middle East sees balanced Group I demand and supply, tempered Group II imports demand  Asian Group III producers focused on Europe, US due to higher netbacks

Denmark playmaker Mie Højlund speaks to us about Denmark's evolution in recent years, how well-defined her and every squad member's job in the team is and Wednesday's decisive match against Norway. Group II continues to throw up surprise twists and Katrine Lunde is handball's version of a cheat code.

Friday night's antics throw Group II wide open, which caught us all by surprise. Germany's Alina Grijseels and Emily Bölk reflect on their huge win over Netherlands (5:30 mins). We speak about the first batch of teams with genuine hopes of semi-final spot and discuss what they need to do to reach the final weekend and maybe even claim gold. Grace Zaadi speaks about France's unusually perfect start to the championship, managing player time, the crucial showdown with Montenegro and what France need to improve on to go all the way (27:30 mins).

Chemo-Dynamically Tagged Groups of CEMP Stars in the Halo of the Milky Way I Untangling the Origins of CEMP- s and CEMP-no Stars by Joseph Zepeda et al. on Monday 26 September We construct a sample of 644 carbon-enhanced metal-poor (CEMP) stars with abundance analyses based on moderate- to high-resolution spectroscopic studies. Dynamical parameters for these stars are estimated, based on radial velocities, Bayesian parallax-based distance estimates, and proper motions from Gaia EDR3 and DR3, supplemented by additional available information where needed. We apply the HDBSCAN clustering method to the specific energies and actions (E, Jr , J{phi}, Jz ), obtaining 39 individual Chemo-Dynamically Tagged Groups (CDTGs) of CEMP stars. The stars in the full sample of CDTGs exhibit large and statistically insignificant dispersions in [Fe/H], [C/Fe]c, and [Mg/Fe], when compared to random draws from their parent sample. When the clustering is performed on CEMP stars separated into the morphological groups in the Yoon-Beers Diagram, the Group I (primarily CEMP-s and CEMP-r/s) stars exhibit lower (but still statistically insignificant) dispersions in [Fe/H], and larger (statistically insignificant) dispersions in [C/Fe]c and [Mg/Fe]. In contrast, the Group II (primarily CEMP-no) stars exhibit clear similarities, with very low, highly statistically significant, dispersions in [Fe/H] and [C/Fe]c. These results strongly indicate that Group I CEMP stars received their carbon enhancements from local phenomena, such as mass transfer from a evolved binary companion in regions with extended star-formation histories, while the CDTGs of Group II CEMP stars formed in low-metallicity environments that had already been enriched in carbon, likely from massive rapidly rotating ultra and hyper metal-poor stars and/or supernovae associated with high-mass early generation stars. arXiv: http://arxiv.org/abs/http://arxiv.org/abs/2209.12224v1

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.16.507381v1?rss=1 Authors: Khoo, S. Y.-S., Samaha, A.-N. Abstract: After a history of intermittent cocaine intake, rats develop patterns of drug use characteristic of addiction. The dorsal striatum is involved in the increased pursuit of cocaine after intermittent drug self-administration experience. Within the dorsal striatum, chronic cocaine use changes metabotropic glutamate type II receptor (mGlu2/3) density and function. We examined the extent to which activity at these receptors mediates responding for cocaine after intermittent cocaine use. In Experiment 1, male Wistar rats (n = 11) self-administered 0.25 mg/kg/infusion cocaine during 10 daily intermittent access (IntA) sessions (5 min ON/25 min OFF, for 5 h/session). We then examined the effects of intra-dorsal striatum infusions of the mGlu2/3 receptor agonist LY379268 (0, 1, and 3 g/hemisphere) on cocaine self-administration under a progressive ratio schedule of reinforcement. We observed a non-significant tendency for LY379268 to reduce responding for cocaine. In Experiment 2, we used a larger sample of male (n = 11) and female (n = 10) rats. Across 10 IntA sessions, the sexes showed similar levels of cocaine intake. Across the sexes, locomotion significantly increased over sessions, suggesting that rats developed psychomotor sensitization to self-administered cocaine. After 10 IntA sessions, intra-dorsal striatum LY379268 significantly reduced breakpoints achieved for cocaine, active lever presses, and cocaine infusions earned under progressive ratio. LY379268 had no effects on locomotion or inactive lever presses, indicating no motor effects. These results suggest that mGlu2/3 receptor activation in the dorsal striatum suppresses incentive motivation for cocaine, and this holds promise for anti-addiction therapeutics. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

The boys discuss old stories and the biggest scams on Earth

SINGAPORE (ICIS)--In this episode of the ICIS Asia podcast, Jasmine Khoo speaks with Matthew Chong, editor for the ICIS Asia Base Oils market on the recent developments in the regional market.The recent spike in crude and gasoil prices due to the Russia-Ukraine war and lockdowns in China to curb the rapid spread of Covid-19 infections has had a significant impact on the base oils industry.  Asia Group I spot supply limited; Group II supply to tighten further  Arbitrage window from Asia to Europe may open China demand to be curbed in near-term on lockdowns  Overall H2 2022 demand to pick up as economies re-open 

The boys discuss the topics of last episode to Cage for his reactions.

Retired agent and podcast host Jerri Williams interviews the victims of a loan shark and extortion investigation, a spin-off case of her Group II business-to-business telemarketing undercover case. During a proffer meeting, brothers Andy and Gary Last Name Unused (LNU) who were the subjects of her fraud case, confide that they had been getting short-term loans from the owner of a check cashing agency at interest rates exceeding 500 percent per year. They further revealed they were the victims of a loan shark and credit extortion attempt and that they had been threatened at gunpoint if they didn't pay up.  Check out episode show notes, photos, and related articles.  https://jerriwilliams.com/244-jerri-williams-loan-shark-check-cashing-extortion-case/   Donate to the FBI Agents Association here: https://www.fbiaa.org/ways-to-donate or text FBIAA to 50155. Join my Reader Team to get the FBI Reading Resource - Books about the FBI, written by FBI agents, the 20 clichés about the FBI Reality Checklist, and keep up to date on the FBI in books, TV, and movies via my monthly email. Join here. http://eepurl.com/dzCCmL  Jerri Williams, a retired FBI agent, author and podcaster, attempts to relive her glory days by writing and blogging about the FBI and hosting FBI Retired Case File Review, a true crime/history podcast. Visit her website to check out her books, available as audiobooks, ebooks and paperbacks wherever books are sold. https://jerriwilliams.com/books/

# This week the second group of our Executive Leadership Programme participants. Linda Agnew, Jane Britt and Helen Freris outline their reasons for participating and their hopes for the programme and the next steps in their leadership journeys.

This week we are thrilled to have Deborah Ryan of Deborah A. Ryan & Associates join the Addicts to discuss state and federal accessibility requirements. These sections of code are technical, they can be complicated, but they are incredibly important to understand. We discussed how developers can ensure compliance with accessibility requirements during the planning and design stage to avoid costly mistakes. We cover a number of specific topics including the differences between Group I and Group II units and when each unit type must be provided, the definition of a “Townhouse” and how that is changing, the process for filing variance applications and why you might need a CD burner before you can submit one. We personally learned a ton throughout recording this episode and we know you will too. Thanks for listening & for sharing the Podcast with a friend!

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.17.301259v1?rss=1 Authors: Funk, M., Schuelert, N., Jaeger, S., Dorner-Ciossek, C., Rosenbrock, H., Mack, V. Abstract: Animal models reflecting human risk for schizophrenia are essential research tools for gaining further insight into the convergence of CNS pathology and clinical biomarkers. Amongst the variety of animal models that display schizophrenia-related neuronal network deficits, transgenic mice for rare and highly penetrant copy number variants (CNVs) provide a unique opportunity to study pathological correlates in models with strong construct validity. The Df(h15q13)/+ mouse model of the human 15q13.3 microdeletion CNV has been shown to mimic deficits in parvalbumin positive (PV+) interneuron and cortical network function. However, the corresponding changes in synapse density and activity within the medial prefrontal cortex (mPFC) have not been described. Using high-content immunofluorescence imaging, we have shown a reduced density of PV+ neurons and inhibitory synapses in the mPFC of Df(h15q13)/+ mice. We found that the reduced detection of PV+ synapses were accompanied by changes in spontaneous inhibitory and excitatory synaptic activity onto layer 2/3 pyramidal neurons. The aberrant cortical function was also evident in awake animals by a reduced high frequency auditory steady-state responses (ASSR), reliably monitored by EEG. Importantly, the imbalance of excitatory to inhibitory function could be attenuated on a cellular and cortical network level by activation of mGlu2/3 receptors, indicating the relevance of excessive excitatory transmission to the cortical network deficit in the Df(15q13)/+ mouse model. Our findings highlight the preclinical value of genetic risk and in particular CNV models such as the Df(15q13)/+ mice to investigate pathological network correlates of schizophrenia risk and to probe therapeutic opportunities based on clinically relevant biomarkers. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.06.03.130724v1?rss=1 Authors: Kristaponyte, I., Beebe, N. L., Young, J. W., Shanbhag, S. J., Schofield, B. R., Galazyuk, A. V. Abstract: Little is known about the functions of group II metabotropic glutamate receptors (mGluRs2/3) in the inferior colliculus (IC)-a midbrain structure that is a major integration region of the central auditory system. We investigated how these receptors modulate sound-evoked and spontaneous firing in the mouse IC in vivo. We first performed immunostaining and tested hearing thresholds to validate VGAT-ChR2 transgenic mice on a mixed CBA/CaJ x C57BL/6J genetic background. Transgenic animals allowed for optogenetic cell type identification. Extracellular single neuron recordings were obtained before and after pharmacological mGluR2/3 activation. We observed increased sound-evoked firing-as assessed by the rate-level functions-in a subset of both GABAergic and non-GABAergic IC neurons following mGluR2/3 pharmacological activation. These neurons also displayed elevated spontaneous excitability and were distributed throughout the IC area tested, suggesting a widespread mGluR2/3 distribution in the mouse IC. Copy rights belong to original authors. Visit the link for more info

F&L Asia's Editor-in-Chief, Vicky Denton, interviews Tim Nadasdi, Product Development Advisor, Basestocks and Specialties at ExxonMobil Fuels and Lubricants discuss the future of Group I and Group II base oils in Asia, Europe and the Americas, as well as the effect that the COVID-19 pandemic is having on base oil and lubricant manufacturers large and small.

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The school has had considerable success in basketball The girls' basketball team, led since 1972 by New Jersey's winningest girls' basketball coach, Jeff Jasper, has won 30 consecutive league titles (1979 through 2008), and seven county championships to go along with multiple state titles. The girls' basketball team won the Group III state championship in 1981 (vs. Camden Catholic High School), 1982 (vs. North Hunterdon High School) and 1989 (vs. Mainland Regional High School), and the Group II title in 2005 and 2008 (vs. Rumson-Fair Haven High School in both years). In 2008, the Indians won the Group II State title with a 58–52 win against Rumson-Fair Haven Regional High School, qualifying for the state Tournament of Champions, and giving Jasper the 800th coaching victory. Jasper was inducted by the New Jersey State Interscholastic Athletic Association into its Bollinger High School Hall of Fame in 2006. The 2010 girls' basketball team was NBIL champions and won the North I, Group III state sectional title, defeating top-seed Teaneck High School 51-47. Jasper earned his 900th win in January 2013, joining Bob Hurley as the only other coach in state history to reach that mark. On January 11, 2018, Jasper earned his 1,000th career coaching victory with a 73-25 win against Northern Highlands Regional High School, becoming the first girls basketball coach in New Jersey to reach this milestone, joining Hurley again as the only other high school basketball coach in New Jersey with 1,000 or more wins @jasperpascack --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app Support this podcast: https://anchor.fm/kevin-furtado/support

In this episode of FBI Retired Case File Review, I interview Karl LNU, who asked that I not use his last name (LNU stands for last name unknown - or in this case unused). Karl was investigated, charged and convicted of bribing corrupt purchasing agents to approve invoices for over-priced and inferior lighting and maintenance supplies. The scam was operated by phone. Karl, his business partner and their employees made telemarketing calls to unsuspecting businesses throughout the United States and ripped them off with the help of their own greedy employees. Karl pled guilty and served time for business to business telemarketing fraud, but his sentence was reduced significantly based on his decision to become a cooperating witness, assisting a multi-agency Group II undercover investigation targeting the business to business telemarketing fraud industry in the Philadelphia area. This was one of my economic crime cases and the work I did with my U. S. postal inspector partner resulted in 16 search warrants and 25 convictions.

News reporter Christie Moffat chats with ICIS senior editor Judith Taylor about the latest market trends in US base oils, including price movement, supply and demand, and the increasing shift from Group I to Group II base oils in North America.

It's a powerful story from the days of Elisha, an Old Testament prophet. The Syrians, have laid siege to Samaria, Israel's northern capital, cutting off its food supply. When starvation begins to turn the people into dry sticks, four lepers decide to turn themselves over to the enemy. The worst that could happen is that they will kill them, but they might just give them something to eat. They arrive at the Syiran Camp and get the surprise of their lives. There's enough food and supplies for thousands, but no soldiers. The four lepers begin to gorge themselves on the food, but then they remember the starving people back in the city. They return and share the good news. Today's message from Acts 10 faces us with the question facing the lepers, ”Will we gorge ourselves on Christ's forgiveness through Calvary or will we break out of our "in" group and share the incredible news?”

Background: Laser lithotripsy is an established endourological modality. Ho:YAG laser have broadened the indications for ureteroscopic stone managements to include larger stone sizes throughout the whole upper urinary tract. Aim of current work is to assess efficacy and safety of Ho: YAG laser lithotripsy during retrograde ureteroscopic management of ureteral calculi in different locations. Methods: 88 patients were treated with ureteroscopic Ho: YAG laser lithotripsy in our institute. Study endpoint was the number of treatments until the patient was stone-free. Patients were classified according to the location of their stones as Group I (distal ureteric stones, 51 patients) and group II (proximal ureteral stones, 37). Group I patients have larger stones as Group II (10.70 mm vs. 8.24 mm, respectively, P = 0.020). Results: Overall stone free rate for both groups was 95.8%. The mean number of procedures for proximal calculi was 1.1 +/- 0.1 (1-3) and for distal calculi was 1.0 +/- 0.0. The initial treatment was more successful in patients with distal ureteral calculi (100% vs. 82.40%, respectively, P = 0.008). No significant difference in the stone free rate was noticed after the second laser procedure for stones smaller versus larger than 10 mm (100% versus 94.1%, P = 0.13). Overall complication rate was 7.9% (Clavien II und IIIb). Overall and grade-adjusted complication rates were not dependant on the stone location. No laser induced complications were noticed. Conclusions: The use of the Ho: YAG laser appears to be an adequate tool to disintegrate ureteral calculi independent of primary location. Combination of the semirigid and flexible ureteroscopes as well as the appropriate endourologic tools could likely improve the stone clearance rates for proximal calculi regardless of stone-size.

Shadrin, S (Universiteit van Amsterdam) Thursday 07 February 2013, 15:00-16:00

How do you respond to trouble? Do you sabotage yourhealth? Do you drain your emotional bank account? Are an internally referencing person or externally referencing? Which type of Vitamin C is right for you? Can Vitamin D help you achieve optimum health. Vitamin C As an immune system enhancer, vitamin C provides protection from oxidation, aging, cancer, and the harmful effects of pollution. It also prevents infections. It has been shown to reduce cholesterol, reduce high blood pressure, and prevent atherosclerosis. Vitamin C is one of the most powerful and really important anti-oxidants. Use plain old ascorbic acid for people eating fat and protein rich diets, especially on the inflammation reducing programs. If you are on a mostly a fruit and vegetable diet, use calcium ascorbate (not this product). A healthy daily supply Vitamin C should include Bioflavonoids from varied natural sources, but for dealing with chronic pain and inflammation (the mini-scurvy) we need to supply a large dose of good old ascorbic acid. http://life-enthusiast.com/usa/vitamin-crystals-p-530.html Metabolic Group I requires the ascorbic acid form because it acidfies the slow oxidizer, but alkalizes the sympathetic. Metabolic Group II requires the calcium ascorbate form because it alkalizes the fast oxidizer and acidifies the parasympathetic. Among foods, brocolli is a Group I food and cauliflower is a Group II food. Kinesiology David R. Hawkins, M.D., Ph.D., Director of the Institute for Advanced Spiritual Research, is an internationally known author, spiritual teacher, and authority within the fields of consciousness research and spirituality. His published works and recorded lectures have been widely recognized as unique in that a very advanced state of spiritual awareness occurred in an individual with a scientific and clinical background who was later able to explain the unusual phenomenon in a clear and comprehensible manner. http://www.amazon.com/Power-vs-Force-Determinants-Behavior

Tue, 3 Feb 2009 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/9651/ https://edoc.ub.uni-muenchen.de/9651/1/Roemer_Susanne_Rebecca.pdf Römer, Susanne Rebecca

Professor Anna Marie Pyle discusses new findings about RNA processing and the form-function relationship of Group II introns and their evolution.

Chaperonins are highly allosteric double-ring ATPases that mediate cellular protein folding. ATP binding and hydrolysis control opening and closing of the central chaperonin chamber which transiently provides a protected environment for protein folding. During evolution, two distinct strategies to close the chaperonin chamber have emerged. Archaeal and eukaryotic chaperonins contain a built-in lid, whereas bacterial chaperonins use a ring-shaped cofactor as a detachable lid. The present work contributes to the current mechanistical understanding of group II chaperonins by unraveling key functions of the built-in lid. In addition to physically encapsulating the substrate, the lid-forming apical protrusions also play a key role in regulating chaperonin function and ensuring its activity as a “two-stroke” molecular machine. By comparative investigation of two distinct chaperonin systems, namely TRiC and Mm-Cpn, this study uncovers a remarkable degree of mechanistic and functional conservation between group II chaperonins from eukaryotic and archaeal origin, despite their evolutionary distance.

Chaperonins are a specific class of barrel-shaped chaperones, present in almost all organisms. Newly synthesized proteins encapsulated by the chaperonin can attain their native structure unimpaired by aggregation during repeated cycles of ATP-dependent binding and release. Chaperonins are generally divided into two groups. Group I chaperonins, such as the barrel-shaped GroEL oligomer, are found predominantly in bacteria and cooperate with cofactors of the Hsp10 familly (i.e. GroES). The Group II chaperonins, on the other hand, do not require a Hsp10- cofactor and are found in the eukaryotic cytosol and in archaea. The function of GroEL is understood in great detail and the substrate interaction proteome has been recently identified. In contrast, our knowledge about the natural substrates of Group II chaperonins is deficient and as a consequence, mechanistical studies on Group II chaperonins have been limited to using the eukaryotic model substrates actin and tubulin as well as heterologous model substrates. In the present study, the complete substrate spectrum of a Group II chaperonin, the thermosome (Ths) of the mesophilic archaeon Methanosarcina mazei (M. mazei), was analysed for the first time. In addition, the unique coexistence of both the goup I and the group II chaperonins in M. mazei, which was confirmed in the initial part of the study, provided the opportunity to obtain new insights into how the substrate selection differs between the two chaperonin groups. For these purposes, the chaperonin substrates were isolated by immunoprecipitation of the chaperonin-substrate complexes and identified by liquid chromatography coupled mass spectrometry (LC-MS) using three different approaches: LC-MS after separation of the proteins (i) by classical 2D-PAGE, (ii) by difference gel electrophoresis (Ettan DIGE) and (iii) by 1D-PAGE. Analysis of substrates of both the thermosome (MmThs) and GroEL/GroES (MmGroEL, MmGroES) of M. mazei revealed that each chaperonin handles a defined set of substrates, and both chaperonins contribute to the folding of ~17% of the proteins in the archaeal cytosol. Bioinformatic analysis revealed that the chaperonin specificity is governed by a combination of a various physical properties (hydrophobicity, net charge and size), structural features (i.e. the domain fold), and less concrete characteristics like the evolutionary status and, in this context, the phylogenetic origin of the substrate.

In this study the effects of the OvSynch procedure on ovarian function and fertility of acyclic cows and those with ovarian cysts were investigated and compared with cycling cows in an OvSynch programme. This field trial was conducted on 50 farms in a practice district in Upper Bavaria between November 2002 and November 2003 and included a total of 199 dairy cows. Cows were examined by rectal palpation and ultrasound before the OvSynch programme was initiated. In cases where ovarian cysts were detected (one or more follicles >2.5 cm), the OvSynch programme was started immediately (n = 89; Group III). If no ovarian cysts were present, a milk sample (Day -10) was collected for the determination of the progesterone concentration (enzyme-immuno-assay in skimmed milk) and the OvSynch programme was started 10 days later. All cows were treated with GnRH (Day 0), PGF2α (Day 7) and GnRH (Day 9) and inseminated 15-20 hours after the second injection of GnRH. Milk samples were collected from all cows on Day 0 and 7, on the day of artificial insemination and 10 days later. Cows without ovarian cysts were classified in two groups retrospectively according to the progesterone concentration on Day -10 and Day 0: Cows with low progesterone (< 0.5 ng/ml) on both occasions were considered to be acyclic (n = 39; Group II); all other cows were assumed to be cycling (n= 71; Group I). The percentage of cows with a high progesterone value at the first injection of GnRH was 73.2%, 0% and 13.5% in Groups I, II and III respectively. The percentage of cows with a high progesterone value was 45.1%, 36.8% and 57.3% on Day 7 and 84.5%, 92.3% and 82.9% 10 days after artificial insemination in Groups I, II and III respectively. The synchronization rate was 80.3%, 84.2% and 80.7% (Groups I, II and III). The conception rate during the OvSynch programme was 47.9% in cycling cows (Group I), 71.8% in acyclic cows (Group II), and 31.5% in cows with ovarian cysts (Group III). Judged by the progesterone levels, the results of this study show that it was possible to induce luteal function in a high number of acyclic cows. The results also suggest that this treatment can be applied successfully in cycling and acyclic cows when no ovarian cysts are present.

In 38 traumatic knee joint effusions the proteolytic enzyme PMN-elastase (PMN-E) and the repair marker procollagen III aminoterminal peptide (PIIINP) were determined. According to the period between trauma and first aspiration of the effusion, the patients were divided into 3 groups. Group I (17 patients; period between trauma and first aspiration not longer than 72 hours) showed high concentrations of PMN-E (up to 5400 ng/ml) and low concentrations of PIIINP (